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Las instituciones de educación superior demandan de sus nuevos estudiantes la madurez necesaria para adecuarse y adoptar sus responsabilidades como nuevos miembros de la comunidad universitaria. Tal proceso de adaptación sucede en una etapa de complejos cambios, por lo cual, un significativo número de ellos presentan altas probabilidades de ocurrencia respecto al aparecimiento de estrés, ansiedad y depresión. En función de ello, se presenta una investigación realizada a partir de dos grupos estudiantiles hondureños con rendimiento académico diferenciado, con el propósito de analizar la relación entre las variables de alteraciones de salud mental y adaptación universitaria. La investigación se desarrolla con un enfoque cuantitativo de naturaleza descriptiva, correlacional y de corte transversal. La Escala de Depresión, Ansiedad y Estrés (DASS-21) y el Cuestionario de Vivencias Académicas, versión reducida (QVA-r) se aplicaron a una muestra total de 871 estudiantes pertenecientes a la Universidad Nacional Autónoma de Honduras. Los resultados indican asociaciones negativas y estadísticamente significativas entre las dimensiones de alteraciones de salud mental y adaptación universitaria. Además, se evidencian diferencias en las variables analizadas al contrastar grupos de bajo y alto rendimiento académico, principalmente en lo referido a las dimensiones de adaptación universitaria vinculadas con los factores de carrera y estudio. Finalmente, se discuten las implicaciones de los hallazgos para el campo educativo y, sobre todo, para la práctica de la orientación psicopedagógica en educación superior.

El norte de Baja California (NBC) está caracterizado por dos subregiones las Sierras Peninsulares de Baja California (SPBC) y el Valle de Mexicali (VM). En el NBC existen ciudades en las que su población pudiera beneficiarse del funcionamiento de un Sistema de Alerta Sísmica Temprana (SAST). Con el propósito de implementar un SAST, que permita emitir notificaciones previas al arribo de las ondas sísmicas generadas por la ocurrencia de algún sismo relevante en el NBC, evaluamos la capacidad de respuesta de la Red Sismológica del CICESE (RSC). Las señales sísmicas de las estaciones de esta red se envían al centro de procesamiento ubicado en el CICESE usando distintos medios de transmisión. De éstos, destacan las transmisiones por módem de Internet por módem telefónico y celular con tiempos de latencia bajos (< 2 s). La evaluación de la RSC la hicimos vía el sistema de adquisición y detección SeisComP3 y el método Virtual Seismologist (VS). Esta evaluación inició en abril de 2017 y dio como resultado un catálogo de más de 5,000 sismos (1.0 ≤ M ≤ 5.7) registrados y procesados con SeisComP3/VS. Con la cobertura geográfica actual de la red y dependiendo de la zona de ocurrencia del sismo, puede notificarse a la población con una anticipación de hasta 20 segundos (M ≈ 4). Para sismos ocurridos en el VM, existe una buena cobertura y pueden enviarse notificaciones a ciudades como Ensenada y Tijuana; no así para la ciudad de Mexicali. Para sismos de las SPBC, el envío de notificación dependerá de la ubicación del evento ya que la cobertura en las SPBC no es la requerida y además los enlaces de transmisión, presentan una alta latencia. No obstante, consideramos factible la implementación de un SAST para el NBC, si se mejora la cobertura geográfica de las estaciones de la RSC y se usan esquemas de transmisión con tiempos de latencia bajos.

Debido a la gran influencia que tiene el Cosmopolites sordidus (picudo negro) sobre la producción del cultivo de Musa AAB en la zona de El Carmen, Manabí, Ecuador, se realizó el presente trabajo de investigación en el laboratorio de microbiología de la Universidad Laica Eloy Alfaro de Manabí, Extensión El Carmen, con el objetivo de evaluar cepas monoespóricas y poliespóricas de Beauveria bassiana y Metarhizium anisopliae. La evaluación se realizó en trampas tipo sándwich con cuatro tratamientos y cinco repeticiones en un Diseño Completamente al Azar (DCA). Los resultados obtenidos del seguimiento en 24 días mostraron que la cepa de Metarhizium anisopliae alcanzó el 16% de mortalidad, Beauveria bassiana 74% y la mezcla de los dos hongos el 78 %, lo que indica que se obtuvo mejor control del picudo negro al realizar una mezcla de los hongos, pero esta alternativa es la de mayor costo, por ello la alternativa de mayor factibilidad para los productores en el control del picudo negro es la aplicación de Beauveria bassiana.

El objetivo del estudio fue determinar si Hibernate 5.4 o MyBatis 3.4 es el más eficiente en referencia al uso del tiempo, la RAM y la CPU. Se implementó dos microservicios REST para realizar operaciones CRUD; los cuales fueron accedidos por servicios REST desarrollados con Hibernate y MyBatis invocados desde un cliente. Nuestros resultados fueron que Hibernate fue el más eficiente respecto al tiempo de procesamiento en un 509.1% y 47.7% para consultas de selección y eliminación, mientras que Mybatis en un 12.7% y 14.2% para consultas de actualización e inserción, correspondientemente. Con respecto al uso de la RAM y la CPU se determinó que MyBatis fue el más eficiente en un 55.2% y 20% respectivamente.

Mass spectrometry (MS) is by far the most used experimental approach in high-throughput proteomics. The ProteomeXchange (PX) consortium of proteomics resources (http://www.proteomexchange.org) was originally set up to standardize data submission and dissemination of public MS proteomics data. It is now 10 years since the initial data workflow was implemented. In this manuscript, we describe the main developments in PX since the previous update manuscript in Nucleic Acids Research was published in 2020. The six members of the Consortium are PRIDE, PeptideAtlas (including PASSEL), MassIVE, jPOST, iProX and Panorama Public. We report the current data submission statistics, showcasing that the number of datasets submitted to PX resources has continued to increase every year. As of June 2022, more than 34 233 datasets had been submitted to PX resources, and from those, 20 062 (58.6%) just in the last three years. We also report the development of the Universal Spectrum Identifiers and the improvements in capturing the experimental metadata annotations. In parallel, we highlight that data re-use activities of public datasets continue to increase, enabling connections between PX resources and other popular bioinformatics resources, novel research and also new data resources. Finally, we summarise the current state-of-the-art in data management practices for sensitive human (clinical) proteomics data.

Leukemogenesis is proposed to result from the continuous interplay between inducive bone marrow (BM) microenvironments and malignant precursor cells. Recent findings point toward an abnormal production of proinflammatory mediators within the BM from acute lymphoblastic leukemia (ALL) patients, although the mechanism underlying this phenomenon is uncertain. Here, we have identified 3 miRNAs, miR-146a-5p, miR-181b-5p, and miR-199b-3p, as potential candidates for TLR8 ligation, which are overexpressed in ALL and show agonist functional binding. When purified from ALL exosomes, they demonstrated their capacity of inducing cytokine production by both, hematopoietic and stromal BM cells. Of note, the exposure of BM cells from ALL patients to the proinflammatory milieu resulting from these miRNAs agonist activity revealed the proliferation of normal progenitors, while poor effects were recorded in the leukemic counterpart. The unconventional roles of the tumor-secreted miRNAs as TLR8 agonist ligands may provide a novel mechanism contributing a tumor-microenvironment feedback loop by switching on proinflammatory pathways that further activate normal hematopoietic precursors and support ALL progression. Secreted B-ALL TLR8-agonist miRNAs are involved in the promotion of proinflammatory microenvironments that target normal hematopoietic cells. B-lineage ALL cells secrete exosomes containing miRNAs endowed with the ability of functionally binding TLR8 in hematopoietic and BM mesenchymal stromal cells. Upon TLR8 signaling, the activation of the NF-kB pathway induces secretion of proinflammatory cytokines that, in turn, promotes cell proliferation in early hematopoietic cell populations, driving a tumor–microenvironment–hematopoietic activation feedback loop that may reduce the normal hematopoietic stem and progenitor cell compartment and facilitate cancer progression.

In this article, we delve into the intricate behavior of electronic mechanisms underlying NMR magnetic shieldings, σ, in molecules containing heavy atoms such as cadmium, platinum, and mercury. Specifically, we explore PtXn^{−2} (X = F, Cl, Br, I; n = 4, 6) and XCl2 Te2 Y2 H6 (X = Cd, Hg; Y = N, P) molecular systems. It is known that the leading electronic mechanisms responsible for the relativistic effects on σ are well characterized by the linear response with elimination of small components model (LRESC). In this study, we present results obtained from the innovative LRESC-Loc model, which offers the same outcomes as the LRESC model but employs localized molecular orbitals (LMOs) instead of canonical MOs. These LMOs provide a chemist’s representation of atomic core, lone pairs, and bonds. The whole set of electronic mechanisms responsible of the relativistic effects can be expressed in terms of both non-ligand-dependent and ligand-dependent contributions. We elucidate the electronic origins of trends and behaviors exhibited by these di- verse mechanisms in the aforementioned molecular systems. In PtX4^{−2} molecules, the predominant relativistic mechanism is the well-established one-body spin-orbit (σ^SO(1) ) mechanism, while the paramagnetic mass-velocity (σ^Mv ) and Darwin (σ^Dw ) contributing mechanisms also demand con- sideration. However, in PtX6−2 molecules, the σ Mv+ Dw contribution surpasses that of the SO(1) mechanism, thus influencing the overall ligand-dependent contributions. As for complexes con- taining Cd and Hg, the ligand-dependent contributions exhibit similar magnitudes when nitrogen is substituted with phosphorus. The only discrepancy arises from the σ^SO(1) contribution, which changes sign between the two molecules due to the contribution of bond orbitals between the metal and tellurium atoms.

A 52-year-old white female patient, a teacher by profession, with no personal pathological history of interest, was admitted to the intensive care unit of the "Lucía Íñiguez Landín" Clinical Surgical Hospital with pneumonia due to COVID-19, for which received several treatments persisting after 20 days of the same a marked severe restrictive ventilatory pattern without achieving improvement and died. Digital radiography images and chest computed tomography images were obtained, and a pulmonary histological study was also performed. The novelty of the case is given by the current relevance of the use of imaging and histological studies of this pandemic entity that has spread rapidly throughout the world whose histopathological changes are not fully understood, which undermines clinical identification adequate treatment of patients and the implementation of effective therapeutic strategies, which is why this article was prepared with the aim of showing the findings in the diagnostic imaging corroborated with histology.

Aging assets late in their cumulative production cycle are increasingly common in the upstream oil and gas industry. Capturing the remaining value from these and extending their life to maximise remaining value prior to abandonment comes with a different set of challenges from the early development phase. The aim of the paper is to showcase how oil and gas companies can structure their strategic planning and decision making in relation to aging assets, identify and evaluate a spectrum of life extending operating strategies, and compare them to cessation of production, incorporating key risks, and uncertainties. Using structured decision techniques, insights about alternative late-life strategies can be gained. This information is essential to decision makers facing the common dilemma of ‘extend or end’ for assets where the bulk of the value has already been captured. We will introduce the fundamentals of Decision Quality and use them to evaluate some of the key engineering aspects associated with late-life asset management. We will showcase an example drawn from consulting for clients in Europe. The worked example addresses the following questions: How can I push the cessation of production date into the future? Does deferring abandonment justify running at a loss for a while? Are incremental investments justified given the remaining field life? How do I determine which options to pursue and develop a viable business case? How do I manage the uncertainties that might offer opportunity or catch me out?

El ahorro de agua es vital para la sostenibilidad ambiental de los procesos; en este sentido, en la fermentación etanólica se la utiliza para la dilución de las mieles azucaradas, para el tratamiento de la levadura y operaciones de limpieza. Reducir agua en la fermentación permite obtener vinos con mayor graduación alcohólica y, por lo tanto, la reducción de la generación del efluente conocido como vinaza en la destilería. En el presente trabajo se propone un proceso de fermentación de alta gravedad, con una temperatura de 30°C, tiempo de alimentación de mosto de 20 horas y tiempo total de 53 horas obteniendo como resultados una concentración de 126,12 g/L de etanol, reducción de 45,66% de consumo de agua, reducción de 38,03% de generación de vinaza y reducción en el consumo energético de 38,35%. Se requirió de un software matemático para la resolución de los modelos matemáticos de fermentación y un simulador de procesos químicos para la resolución de los balances de materia y energía en las columnas de destilación.

The outer membrane (OM) is an essential component of the Gram-negative bacterial cell envelope. Restricted diffusion of integral OM proteins and lipopolysaccharide (LPS) that constitute the outer leaflet of the OM support a model in which the OM is in a semi-crystalline state. The low fluidity of the OM has been suggested to be an important property of this membrane that even contributes to cell rigidity. The LPS characteristics strongly determine the properties of the OM and the LPS layer fluidity has been measured using different techniques that require specific conditions or are technically challenging. Here, we characterize the Escherichia coli LPS fluidity by evaluating the lateral diffusion of the styryl dye FM4-64FX in fluorescence recovery after photobleaching experiments. This technique allowed us to determine the effect of different conditions and genetic backgrounds on the LPS fluidity. Our results show that a fraction of the LPS can slowly diffuse and that the fluidity of the LPS layer adapts by modifying the diffusion of the LPS and the fraction of mobile LPS molecules.

The Trans-Proteomic Pipeline mass spectrometry data analysis suite has been in continual development and refinement since its first tools PeptideProphet and ProteinProphet were published twenty years ago. The current release provides a large complement of tools for spectrum processing, spectrum searching, search validation, abundance computation, protein inference, and more. Many of the tools include machine-learning modeling to extract the most information from datasets and build robust statistical models to compute the probabilities that derived information is correct. Here we present the latest information on the many TPP tools, and how TPP can be deployed on various platforms from personal Windows laptops to Linux clusters and expansive cloud computing environments. We describe tutorials on how to use TPP in a variety of ways and describe synergistic projects that leverage TPP. We conclude with plans for continued development of TPP.

The Human Proteome Organization (HUPO) Proteomics Standards Initiative (PSI) has been successfully developing guidelines, data formats, and controlled vocabularies (CVs) for the proteomics community and other fields supported by mass spectrometry since its inception 20 years ago. Here we describe the general operation of the PSI, including its leadership, working groups, yearly workshops, and the document process by which proposals are thoroughly and publicly reviewed in order to be ratified as PSI standards. We briefly describe the current state of the many existing PSI standards, some of which remain the same as when originally developed, some of which have undergone subsequent revisions, and some of which have become obsolete. Then the set of proposals currently being developed are described, with an open call to the community for participation in the forging of the next generation of standards. Finally, we describe some synergies and collaborations with other organizations and look to the future in how the PSI will continue to promote the open sharing of data and thus accelerate the progress of the field of proteomics.

The Human Proteome Organization (HUPO) Proteomics Standards Initiative (PSI) has been successfully developing guidelines, data formats, and controlled vocabularies (CVs) for the proteomics community and other fields supported by mass spectrometry since its inception twenty years ago. Here we describe the general operation of the PSI, including its leadership, working groups, yearly workshops, and the document process by which proposals are thoroughly and publicly reviewed in order to be ratified as PSI standards. We briefly describe the current state of the many existing PSI standards, some of which remain the same as when originally developed, some of which have undergone subsequent revisions, and some of which have become obsolete. Then the set of proposals currently being developed are described, with an open call to the community for participation in the forging of the next generation of standards. Finally, we describe some synergies and collaborations with other organizations and look to the future in how the PSI will continue to promote the open sharing of data and thus accelerate the progress of the field of proteomics.

The Trans-Proteomic Pipeline mass spectrometry data analysis suite has been in continual development and refinement since its first tools PeptideProphet and ProteinProphet were published twenty years ago. The current release provides a large complement of tools for spectrum processing, spectrum searching, search validation, abundance computation, protein inference, and more. Many of the tools include machine-learning modeling to extract the most information from datasets and build robust statistical models to compute the probabilities that derived information is correct. Here we present the latest information on the many TPP tools, and how TPP can be deployed on various platforms from personal Windows laptops to Linux clusters and expansive cloud computing environments. We describe tutorials on how to use TPP in a variety of ways and describe synergistic projects that leverage TPP. We conclude with plans for continued development of TPP.

MotivationWith the rapidly growing volume of knowledge and data in biomedical databases, improved methods for knowledge-graph-based computational reasoning are needed in order to answer translational questions. Previous efforts to solve such challenging computational reasoning problems have contributed tools and approaches, but progress has been hindered by the lack of an expressive analysis workflow language for translational reasoning and by the lack of a reasoning engine—supporting that language—that federates semantically integrated knowledge-bases.ResultsWe introduce ARAX, a new reasoning system for translational biomedicine that provides a web browser user interface and an application programming interface. ARAX enables users to encode translational biomedical questions and to integrate knowledge across sources to answer the user’s query and facilitate exploration of results. For ARAX, we developed new approaches to query planning, knowledge-gathering, reasoning, and result ranking and dynamically integrate knowledge providers for answering biomedical questions. To illustrate ARAX’s application and utility in specific disease contexts, we present several use-case examples.Availability and ImplementationThe source code and technical documentation for building the ARAX server-side software and its built-in knowledge database are freely available online (https://github.com/RTXteam/RTX). We provide a hosted ARAX service with a web browser interface at arax.rtx.ai and a web application programming interface (API) endpoint at arax.rtx.ai/api/arax/v1.3/ui/.Contactdmk333@psu.edu

El objetivo de este estudio fue identificar los motivos intrínsecos que guían el comportamiento de los pequeños productores en relación con su resistencia a ser parte de alguna organización. El jitomate (Solanum lycopersicum L.) es el segundo producto agropecuario de mayor exportación de México, con presencia en 291 de los 570 municipios del estado de Oaxaca. Particularmente, en San Pablo Güilá existen 42.8 ha de invernaderos con jitomate para exportación; de esta superficie; 52% pertenece a 27 productores organizados en una cooperativa mientras que 48% restante es propiedad de 153 productores que trabajan independientemente. La investigación se llevó a cabo desde un enfoque cualitativo, con alcance exploratorio y descriptivo. La técnica utilizada fue la encuesta, adaptando el Cuestionario a la Descripción de Valores de Schwartz y se aplicó a productores que trabajan individualmente. Se encontró que los valores Tradición, Conformidad y Poder, son altos; Logro, Estimulación, Autodirección y Benevolencia son bajos; y Seguridad, Hedonismo y Universalismo son muy bajos. Se concluye que los agricultores tienen una orientación individualista enfocada en el éxito personal logrado por habilidades propias; así como en el control y en el dominio sobre personas y recursos.

Las biotecnologías reproductivas, constituyen una serie de herramientas para la conservación de las razas consideradas en peligro de extinción como los burros. El objetivo de esta investigación fue evaluar el uso de inductores de capacitación espermática en semen congelado-descongelado de asnos. Se colectaron 5 asnos, localizados en el Valle de Aburrá con edades entre 4-8 años, se obtuvieron 3 eyaculados por animal, mediante vagina artificial, el semen recién recolectado fue diluido en proporción 1:1 en Equiplus® para ser criopreservado. Después, se descongelaron dos pajillas de 0.5 mL cada una del mismo eyaculado en un baño María a 37 °C, este volumen fue divido en 8 submuetras y 125 μL de semen fueron depositados en tubos eppendorf, posteriormente se adicionó a cada tubo el inductor de capacitación pentoxifilina (PTX) 2.5, 5 y 7.5 mM, ácido etilendiaminotetraacético (EDTA) 0.5, 1 y 1.5 mM, heparina (HEP) 1.1 mM como control positivo y sin aditivo (control) por 20 minutos. Se evaluaron variables de cinética espermática sistema IVOS (Hamilton Thorne), vitalidad espermática (VE) mediante el kit de viabilidad LIVE/DEAD, integridad acrosómica con (FITC-PSA), mientras que la capacitación, potencial mitocondrial e ingreso de Ca2+, fue evaluado usando un citómetro de flujo (FORTESSA LSR, BD Biosciences, EE. UU). Se observó que la movilidad total (MT) y la vitalidad espermática (VE) aumentaron en relación con el control, con el uso de 2,5 y 5.0 mM de PTX respectivamente (p

La investigación muestra el grado de relación existente entre el desempeño docente y la formación investigativa en los estudiantes de la Universidad Nacional de Educación Enrique Guzmán y Valle, Lima, Perú. Es un estudio descriptivo aplicado a una muestra de 242 estudiantes de dicha universidad. En la recolección de datos, se empleó un cuestionario con parámetros de respuestas de la escala Likert. En base a la prueba Alfa de Cronbach, los instrumentos usados para medir la confiabilidad de las variables desempeño docente y formación investigativa mostraron índices de 0,960 y 0,932, respectivamente. El coeficiente de correlación Rho de Spearman fue de 0,663, con evidencia de una correlación positiva alta. Los hallazgos corroboran que el desempeño docente se relaciona significativamente con la formación investigativa.

The role and the degree to which environment and geographic isolation contribute to phenotypic diversity has been widely debated. Here, we studied phenotypic variation (morphology and plumage reflectance) in the Sinaloa Wren, an endemic bird distributed throughout the tropical dry forest (TDF) on the Mexican pacific slope where a pronounced variability in environmental conditions has been reported. In particular, we aimed: 1) to characterize phenotypic variation between subspecies; 2) to analyze the relationship between phenotypic and environmental variation in the context of classic ecogeographic rules, such as Bergmann’s, Allen’s, Gloger’s, and Bogert’s, and to quantify the relative roles of environment and geographic isolation and their interaction in shaping phenotypic variation; and 3) to test for niche conservatism between subspecies. Our data revealed significant differences among subspecies morphology and plumage reflectance. The environment explained a higher proportion of the morphological variation, while geography explained a smaller proportion. However, variation in plumage reflectance was mainly explained by the joint effect of geography and environment. Our data did not support for Bergmann´s and Allen´s rule. However, longer tails and wings were positively associated with higher elevations, larger tarsus and culmens were positively related to higher latitudes and to greater tree cover, respectively. Our data partially supported Gloger´s rule, where darker plumages were associated with more humid environments. The effects of temperature on plumage coloration were more consistent with Bogert´s rule. In addition, we found darker plumages related to higher levels of UV-B radiation. Finally, niche divergence was detected betweenT.s.cinereusandT.s.sinaloavs.T.s.russeus. In a continuously distributed ecosystem such as the TDF on the pacific slope of Mexico, the environmental conditions and geographic isolation have played an important role in promoting phenotypic differentiation in the Sinaloa Wren.

This article aims to provide a guideline to better decision quality on multi-company upstream projects. The scope is to provide a high-level overview of what should be included in a decision quality process, when companies with different levels of ownership and influence on the decision-making process naturally tend to have different approaches towards risks and decision management. It is well known in our industry that there is a predominance of multicompany participation in these projects and the paper will provide guidelines that will ultimately provide better decision quality and participant's alignment. Normally high-risk upstream projects have multi-company ownership. However, it has been noticed that companies tend to face decision management differently, which causes unnecessary delays on budget approvals and even operational timeline. Procedures to normalize the definition of an initial decision frame and creation of solutions based on a good set of alternatives are paramount to facilitate discussions and drive final recommendations. In summary, companies’ alignment on decision-making processes is key to quality, speed, and effectiveness of those decisions and critical to project success. Alignment between partners on pivotal decisions can significantly improve project delivery. The main results are practical guidelines for generating (a) decision framing, (b) strategies, (c) alternatives and potential consequences, and (d) logical analysis, partners’ alignment and commitment to action.

El objetivo del trabajo fue evaluar la Composición química (CQ), Digestibilidad in vitro de la materia seca (DIVMS) del heno de alfalfa (Medicago sativa L.) simultáneamente la producción de gas in vitro (PGIV). La formulación del problema plantea que: ¿Con la aplicación de las enzimas fibrolíticas exógenas (xilanasas) al sustrato y el licor ruminal, mejorará la digestibilidad in vitro en heno de alfalfa? Se justifica por mejorar la digestibilidad en heno de alfalfa, adicionando enzimas en la alimentación. El método in vitro consistió en una incubación del alimento con fluido ruminal durante 48 h a 39ºC, donde se evaluó simultáneamente la (DIVMS) 24 y 48 h y la producción de gas in vitro (PGIV) a las 3, 6, 12, 24 y 48 h de incubación al azar, con cuatro tratamientos y tres repeticiones, mediante la aplicación de enzimas exógenas en tres niveles comparado con un testigo, las siguientes dosis: 0 (control), 2000 UI (T1), 4000 UI (T2) y (T3) 8000 UI kg-1 MS. Se obtuvo el porcentaje de DIVMS a las 24 y 48 horas utilizando xilanasas, se notó una mayor DIVMS a las 24 h en el T2: 38.87 % y relación en tiempo de digestibilidad hasta las 48 h con el 44.06 % con diferencias significativas entre tratamientos (P

Chronic respiratory diseases have been on the rise, especially due to COVID-19, extreme air pollution, and other external circumstances. Millions of people around the world suffer from progressive lung diseases and require supplemental oxygen therapy to maintain blood oxygen (SpO2) levels above 90% to prevent hypoxic episodes that can lead to further organ damage. Today, these chronic episodes are more prevalent in aging populations suffering from Chronic Obstructive Pulmonary Disorder (COPD). Existing SpO2 measurement equipment, designed to assist with treating COPD at home, are suboptimal as they cannot measure SpO2 levels continuously, meaning supplemental oxygen devices are unable to adjust oxygen flow rates to the patient’s needs. These discrepancies can result in hypoxic episodes of blood oxygen levels below 90%. Following this need, our team demonstrates preliminary results of the novel placement of a SpO2 sensor in the nasal septum to allow for comfortable and sustained SpO2 measurement. This will improve the experience of home-respiratory care with continuously obtained data from a novel location.