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ABSTRACTAntimicrobial resistance (AMR) in pathogenic bacteria poses a significant threat to public health, yet there is still a need for development in the tools to deeply understand AMR genes based on genetic or structural information. In this study, we present an interactive web database named Blanket Overarching Antimicrobial-Resistance gene Database with Structural information (BOARDS, sbml.unist.ac.kr), a database that comprehensively includes 3,943 reported AMR gene information for 1,997 extended spectrum beta-lactamase (ESBL) and 1,946 other genes as well as a total of 27,395 predicted protein structures. These structures, which include both wild-type AMR genes and their mutants, were derived from 80,094 publicly available whole-genome sequences. In addition, we developed the rapid analysis and detection tool of antimicrobial-resistance (RADAR), a one-stop analysis pipeline to detect AMR genes across whole-genome sequencing (WGSs). By integrating BOARDS and RADAR, the AMR prevalence landscape for eight multi-drug resistant pathogens was reconstructed, leading to unexpected findings such as the pre-existence of the MCR genes before their official reports. Enzymatic structure prediction-based analysis revealed that the occurrence of mutations found in some ESBL genes was found to be closely related to the binding affinities with their antibiotic substrates. Overall, BOARDS can play a significant role in performing in-depth analysis on AMR.IMPORTANCEWhile the increasing antibiotic resistance (AMR) in pathogen has been a burden on public health, effective tools for deep understanding of AMR based on genetic or structural information remain limited. In this study, a blanket overarching antimicrobial-resistance gene database with structure information (BOARDS)—a web-based database that comprehensively collected AMR gene data with predictive protein structural information was constructed. Additionally, we report the development of a RADAR pipeline that can analyze whole-genome sequences as well. BOARDS, which includes sequence and structural information, has shown the historical landscape and prevalence of the AMR genes and can provide insight into single-nucleotide polymorphism effects on antibiotic degrading enzymes within protein structures.

The value of Building Information Modelling (BIM) is widely discussed within all construction stages including the data-driven culture across building processes and sustainable impact in the long term. Yet, there is a need to explore the opportunities of BIM in improving construction materials management (CMM) as a core function of supply chain management. Due to the dearth of studies on BIM potential in improving CMM within the sustainability context, the authors examine the effectiveness and efficiency of BIM-enabled materials management, via three data streams: a literature review, an online survey, and interviews with subject matter experts in the field. This study aims to explore the drivers of BIM-enabled sustainable construction materials management. This is the preliminary study designed to test the initial hypotheses based on an online questionnaire application to derive tacit knowledge from industry and academic experts, followed by short interviews with respondents. Grounded in the comprehensive literature review, 24 indicators were defined for survey purposes. Preliminarily, 206 experts from 10 countries responded to the survey. The results show significant differences in the ranking of the indicators among the five factors. In developing countries, among two groups, industry sample awareness scales demonstrated lower understanding than among academic experts. Another finding relates to the significant agreement in scaling the importance of opportunities among industrial and academic sector experts. The research adds knowledge to deepen the understanding of opportunities of BIM-enabled materials management as a part of building project sustainable performance for industry policy and decision-makers. It also brings attention to the lack of sustainability awareness amongst industry experts in developing countries. Although materials constitute a solid part of any construction project cost, there is still a collaboration gap among designers, materials management, and, more broadly, supply chain management experts.

Three different percentages of carbon nanotubes (CNTs) (0.1%, 0.5%, and 1% by mass of asphalt cement) were used to modify conventional asphalt cement (60/70) in this study. Mechanical properties of modified asphalt cement and mixture were evaluated. Penetration grade, kinematic viscosity, softening point and dynamic shear rheometer test were measured to evaluate physical properties of modified asphalt cement. The results exhibited that modifying asphalt cement with CNTs decreased its penetration and increased its kinematic viscosity and softening point. Rutting parameter increased with CNTs at the given temperature for both unaged and RTFOT-aged samples. Marshall stability tests, low temperature cracking tests, indirect tensile tests and wheel tracking tests were conducted to assess the mechanical performance of modified hot asphalt mixture. The Marshall stability increased with CNTs but no significant difference at 0.5 and 1.0 wt%, while Marshall flow decreased with CNTs. The results of wheel tracking test showed that rut depth decreased by 45% upon adding 0.5% CNTs by weight of asphalt cement; also, this percentage of CNTs endowed improvement in low temperature cracking and indirect tensile strength of the asphalt concrete. This study underlines that adding CNTs into asphalt cement enhances the performance of asphalt concrete pavement in both hot and cold weather, which in turn prolongs the pavement’s service life and saves maintenance expenses.

Understanding the link between the energy-efficiency of buildings and climatic conditions can improve the design of energy-efficient housing. Due to global climate change and growing requirements for building energy-efficiency, the number of publications on climate zoning for buildings has grown over the last 20 years. This review attempted to give the reader an up-to-date assessment of the scientific literature in the field of climate mapping for buildings on a global and national scale, filling in the gaps of previous works and focusing on details that were not presented before. There were 105 scientific sources examined. The most dominant climate zoning variables were thoroughly analyzed. A clear categorization of climate zoning methods with specific criteria was shown. The most used methods were evaluated, emphasizing their similarities and differences, as well as their essential components and advantages. The main literature review was supported with bibliometric and bibliographic analysis. The existence of many climate zoning methods can be an indicator of the lack of agreement on the most effective strategy. A tendency has been established for the popularization among scientists of methods based on machine learning and building energy simulations, which are relatively easy to use and have proven to be the most reliable climate zoning methods. A transformation is emerging by shifting from a climate-based to a building performance-based climate zoning approach.

The latest industrial revolution 4 enabled significant performance improvement through technological advancements. Simultaneously, the industry is setting high-level expectations for changing business practices toward long-term benefits in all three sustainability dimensions. The concept of sustainability embraces all production and operation processes in the Architecture, Engineering, and Construction (AEC) industry. This study systematically explores the literature on sustainability with Enterprise Resource Planning (ERP) and Building Information Modelling (BIM) technologies in the AEC industry and the sustainability vision for their integration. The different types of ERP and BIM implementations have similarities in addressing the broad scope of functionalities. The emergence and proliferation of ERP and BIM have brought crucial changes to the business environment. Further evolution to cloud-based operations is transforming companies from technology-oriented practices to data-centric decision-making smart infrastructures. The narrative literature review investigates the sustainability insights and ideas in ERP and BIM solutions, presenting state of the art on systems integration topics. The relevant literature was retrieved to achieve the research objectives which were qualitatively analyzed to generate the basis for further research.

Photoinduced processes governed by light activated TiO2 have been studied in many ways. One of the most active areas is the development of TiO2 photocatalysis technologies on their application for reducing environmental impacts. The immobilization of TiO2 on solid support, such as cementitious materials, greatly enhances its use in practical applications. In this review, a wide range of applications for achieving eco-efficient building using cementitious composite materials containing TiO2 photocatalyst was presented. The basic mechanism of photocatalysis, such as electron excitation, charge transfer process, reactive oxygen species (ROS) generation, and its role to oxidize the pollutant and microorganisms were extensively discussed. Unlike self-cleaning and air purification systems, the study on the antibacterial function of a cement-based surface containing TiO2 is very limited. In photocatalytic cementitious materials, the key element affecting the photocatalytic performance is the accessible active surface area. However, microstructure of cementitious materials changes with age due to hydration and surface carbonation. Hence, surface area reduction and mass transfer limitation become the main drawbacks of incorporating TiO2 in cementitious materials. This review, therefore, provides the state of the art in photocatalytic cement-based composite materials and identifies the areas in which future improvement is needed.

Changes in climatic conditions are expected globally resulting in a higher rainfall intensity and longer duration of rainfall. The increase in the rainwater infiltration into the soil contributes to many geotechnical issues, such as excessive settlement, retaining wall failure and rainfall-induced slope failures. These geotechnical problems could be mitigated by the improvement of the problematic soil with the incorporation of the unsaturated soil mechanic principles. Dual-porosity soils or soils with bimodal water retention curve (WRC) are able to retain more water during prolonged drying and they would be able to drain out water faster during intense rainfall to maintain the slope stability. The objective of this study is to investigate the characteristics of the unsaturated shear strength of soil with bimodal WRC. In addition, the new mathematical equation is proposed to estimate the unsaturated shear strength of soils with a bimodal WRC. The results of the study indicated that the nonlinearity of the unsaturated shear strength is a function of the shape of bimodal WRC limited by the first and second air-entry value (AEV) of dual-porosity soils. The proposed equation agreed well with the experimental data of the unsaturated shear strength for dual-porosity soil.

Research on the digital built environment in the context of identifying and minimizing clashes is a critical area to investigate owing to the significant influence of clashes on the construction process. This research aims to identify the current state of building information modeling (BIM) enabled clash detection in the architecture, engineering, and construction and operation (AECO) industry of the Republic of Kazakhstan. It further identifies the main reasons for clash occurrence, methods, and practices used to decrease the workload on BIM project teams. It also recognizes the existence of BIM departments (their type and functionalities). It aims to answer whether the transition from clash detection to clash avoidance is possible in a country where BIM technology has just penetrated. This research conducted a literature review and review of current regulatory documents regarding BIM technology, interviews with industry professionals, and a survey among construction companies and design organizations. Although the AECO industry of Kazakhstan has just entered the BIM environment, this research has shown that BIM-enabled clash detection and resolution processes are trying to evolve in parallel. It was concluded that the transition is difficult in a country where document assistance with clash detection and resolution is not well developed.