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COVID-19 has overwhelmed health services globally. Oral antiviral therapies are licensed worldwide, but indications and efficacy rates vary. We aimed to evaluate the safety and efficacy of oral favipiravir in patients hospitalised with COVID-19.We conducted a multicentre, open-label, randomised controlled trial of oral favipiravir in adult patients who were newly admitted to hospital with proven or suspected COVID-19 across five sites in the UK (n=2), Brazil (n=2) and Mexico (n=1). Using a permuted block design, eligible and consenting participants were randomly assigned (1:1) to receive oral favipiravir (1800 mg twice daily for 1 day; 800 mg twice daily for 9 days) plus standard care, or standard care alone. All caregivers and patients were aware of allocation and those analysing data were aware of the treatment groups. The prespecified primary outcome was the time from randomisation to recovery, censored at 28 days, which was assessed using an intention-to-treat approach. Post-hoc analyses were used to assess the efficacy of favipiravir in patients aged younger than 60 years, and in patients aged 60 years and older. The trial was registered with clinicaltrials.gov, NCT04373733.Between May 5, 2020 and May 26, 2021, we assessed 503 patients for eligibility, of whom 499 were randomly assigned to favipiravir and standard care (n=251) or standard care alone (n=248). There was no significant difference between those who received favipiravir and standard care, relative to those who received standard care alone in time to recovery in the overall study population (hazard ratio [HR] 1·06 [95% CI 0·89-1·27]; n=499; p=0·52). Post-hoc analyses showed a faster rate of recovery in patients younger than 60 years who received favipiravir and standard care versus those who had standard care alone (HR 1·35 [1·06-1·72]; n=247; p=0·01). 36 serious adverse events were observed in 27 (11%) of 251 patients administered favipiravir and standard care, and 33 events were observed in 27 (11%) of 248 patients receiving standard care alone, with infectious, respiratory, and cardiovascular events being the most numerous. There was no significant between-group difference in serious adverse events per patient (p=0·87).Favipiravir does not improve clinical outcomes in all patients admitted to hospital with COVID-19, however, patients younger than 60 years might have a beneficial clinical response. The indiscriminate use of favipiravir globally should be cautioned, and further high-quality studies of antiviral agents, and their potential treatment combinations, are warranted in COVID-19.LifeArc and CW+.

The objective was to contribute to the formation of spin-offs in the biotechnology segment in the Amazon, in ICTs, involved with innovation, technology transfer to the market, derived from successful academic ventures. We opted for the exploratory methodology, bibliographic, documentary and with qualitative approach from the theory of innovation that identify the trajectory of the spin-offs, with competencies for the development of innovative products and processes in their market journey. Concluded that in biotechnological innovation in the Amazon, it is necessary to join efforts of the private sector, government, and spin-offs of ICTs. The latter can contribute to skilled professionals and laboratories for R&I, to respond to the needs of sustainable socioeconomic development, through opportunities for biotechnology spin-off as an instrument of technology transfer of ICTs aiming at implementing innovative technologies for market access.

Introducción. La nutrición y salud bucal son temas de interés en salud pública por su alto impacto en el bienestar y desarrollo de las personas. Existe una alta prevalencia e incidencia de caries y malnutrición en los primeros años de vida. Objetivo. Determinar la relación entre el índice de caries en dentición primaria y permanente e índice de masa corporal en niños de 5 a 11 años en las Unidades de Salud de San Miguel Tepezontes y Panchimalco en el año 2019.Metodología. Investigación cuantitativa con una muestra de 265 niños de 5 a 11 años. Se evaluó el índice de masa corporal y el índice de caries; se hizo un análisis estadístico descriptivo e inferencial, realizando la prueba estadística de correlación de Spearman. Resultados. Se encontró que el índice de caries es de 2,11 en dentición permanente con una prevalencia de 70,5 % y el índice de caries de 7,02 en dentición primaria con una prevalencia de un 94,98 %. El coeficiente de correlación de Spearman entre índice de masa corporal e índice de caries en dentición permanente fue de 0,226, que indica una correlación positiva baja y el índice de masa corporal e índice de caries en dentición primaria fue - 0,158, que indica una correlación negativa muy baja. Conclusión. Existe relación entre el índice de caries en ambas denticiones y el índice de masa corporal.

Mushroom cultivation is an economically viable process for the conversion of various lignocellulosic residues. Recently in order to increase the feasibility of mushroom production, research has been carried out to investigate the use of residues as substrates and the possibility of obtaining two or more products in a single bioprocess. The aim of this study wasto investigate the potential of biomass residues from street markets in the city of Manaus (Amazonas, Brazil) as a substrate for the production of oyster mushroom and laccase. Pleurotus ostreatus was cultivated in the following biomass residues: a) peel from the fruit of Astrocaryum aculeatum Meyer, b) peel from the fruit of Bactris gasipaes Kunth, c) fibers from the endocarp of the fruit of Euterpe oleracea Mart. and d) peel from the fruit of Theobroma grandiflorum Schumann. The peel from the fruit of Bactris gasipaes was the best substrate to produce oyster mushroom (4.8 % biological efficiency -ratio between the fresh weight of the mushroom and the dry weight of the compost), and the peel from the fruit of Astrocaryum aculeatum was the best substrate for laccase production (21,766 U/Kg). The present work is important since it allowed us to demonstrate that two biomass residues from Amazonian plants could be utilized to produce mushrooms and laccases.

In this chapter, the authors aim to offer practical guidelines for implementing culturally and linguistically responsive teaching (CLRT) practices for educators working with emergent bilinguals (EBs) with and without disabilities. This chapter begins by defining CLRT and contextualizing the need for CLRT practices through a review of current research at the interface of bilingual and special education. Then, the authors offer practical examples of how teachers can use CLRT to support EBs with or without disabilities. The chapter concludes with an articulation of the authors' vision for the potential of CLRT to support this population of students in dual language bilingual (DLB) classrooms.

Glucocorticoid (GC) therapy is a common treatment used in rheumatic and autoimmune diseases, owing to its anti-inflammatory and immunosuppressive effects. However, GC therapy can also induce a number of adverse effects, including muscle and bone loss, hypertension, metabolic perturbations and increased visceral adiposity. We review available evidence in this area and provide nutritional recommendations that might ameliorate these adverse effects. Briefly, optimizing calcium, vitamin D, sodium and protein intake and increasing consumption of unprocessed and minimally processed foods, while decreasing the consumption of ultra-processed foods, might counteract some of the specific challenges faced by these patients. Importantly, we identify a dearth of empirical data on how nutritional intervention might impact health-related outcomes in this population. Further research is required to investigate the clinical and therapeutic efficacy of these theory-based recommendations.

Objetivo: Realizar un análisis sobre los componentes de la Prótesis Parcial Removible. Método: Se analizaron 10 artículos y libros relacionados al tema de investigación, protesis parcial removible, que se usan en odontología.Resultados y conclusiones: Se determinó una gran variedad de elementos que tienen características e indicaciones especiales y diferentes, se determinó que los ganchos predilectos son los circunferenciales de acker por su versatilidad, los conectores mayores dependen del caso de cada paciente; como conclusión se obtuvo que conociendo los elementos de la PPR sus indicaciones y características, se determinó que el profesional odontólogo tiene la responsabilidad y el criterio para discernir y escoger el aparato protésico adecuado para suplir las necesidades y requerimientos del paciente parcialmente edéntulo, elaborando indicaciones de confección al laboratorio dental cumpliendo con los requisitos biomecánicos, éticos y legales que conforman una PPR.

Objetivo: Conocer la aplicación e implementación de estos programas en los profesionales y estudiantes, identificar la relación que mantiene el diseño digital actualmente, y conocer si estos programas digitales cumplen los principios básicos de la prótesis. Método: Descriptivo documental con revisión bibliográfica en una población de 15 artículos ubicados en base de datos PubMed. Conclusión: La implementación de los programas digitales enfocados en la PPR, actualmente dan resultados significativos y grandes benéficos en la fabricación y diseño gracias a los nuevos materiales aplicados y al software que ayuda a un mejor precisión y adaptación, como también a asegurar una mejor estabilidad y retención del material protésico a comparación de las técnicas tradicionales.

APRESENTAÇÃO DO DOSSIÊ - LUTAS, RESISTÊNCIAS E SABERES POPULARES: A EDUCAÇÃO COMO CAMINHO PARA A EMANCIPAÇÃO

Project Work presented as the partial requirement for obtaining a Master's degree in Information Management, specialization in Knowledge Management and Business Intelligence In today's connected world, people turn more to the web to be informed of the news. Newspapers in an online environment profit from employing subscription models. Despite that Portugal remains one of the countries with higher levels of trust in news, readers present a low propensity to subscribe. Hence, online newspapers' existing customers are a valuable asset. Therefore, it is in the best interest of such businesses to monitor these customers to identify potential churn signs down the line. Customer churn prediction models aim to identify customers most prone to attrite, allowing businesses that leverage them to improve their customer retention campaigns' efficiency and reduce costs associated with churn. Two different research approaches, namely prediction power and comprehensibility, have been at the core of churn prediction literature. Businesses need accurate models to target customers' right subset. However, many models are black-boxes and present reduced interpretability. On the other hand, understanding what drives customers to churn can support managers in making better-informed decisions. This project report presents the development of a plan to tackle churn prediction in a Portuguese newspaper with an online subscription model using Machine Learning methods. The models' performance was evaluated in two experiments. One experiment assessed the performance for all types of subscriptions and another considered only non-recurring subscriptions. The results of the first experiment were tempered by an unplanned marketing campaign that run simultaneously with the experiment on top of the contrasting contexts in which the model was trained and evaluated. On the other hand, the second experiment's results suggest that for non-recurring subscriptions, a phone call from the call centre proved to be an adequate retention measure for probable churning subscribers. Additionally, models' predictors were analysed and it was found that users with lower fidelity rates and few subscriptions present a higher propensity to cancel their subscriptions. The same occurs with users whose product is annual or longer-lasting. These findings shed light on how to minimize churn and improve reader engagement. Based on the models' results, and predictors' analysis, the newspaper decided to implement a re-engagement newsletter to keep users engaged and prevent future churn.