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Anal stenosis is a rare but frustrating condition that usually occurs as a complication of hemorrhoidectomy. The severity of anal stenosis can be classified into three categories: mild, moderate, and severe. There are two main surgical treatments for this condition: scar revision surgery and anoplasty; however, no studies have compared these two approaches, and it remains unclear which is preferrable for stenoses of different severities.To compare the outcomes of scar revision surgery and double diamond-shaped flap anoplasty.Patients with mild, moderate, or severe anal stenosis following hemorrhoidectomy procedures who were treated with either scar revision surgery or double diamond-shaped flap anoplasty at our institution between January 2010 and December 2015 were investigated and compared. The severity of stenosis was determinedWe analyzed 60 consecutive patients, including 36 men (60%) and 24 women (40%). The mean operative time for scar revision surgery was significantly shorter than that for double diamond-shaped flap anoplasty (10.14 ± 2.31 [range: 7-15] minScar revision surgery may be preferable for mild anal stenosis upon conservative treatment failure. Anoplasty is unavoidable for moderate or severe stenosis, where cicatrized tissue is extensive.

Mirror mode waves with anticorrelated density and magnetic field perturbations have been widely observed in the planetary magnetosheaths and solar wind. In this study we examine the time evolution of proton mirror instability based on the hybrid particle simulation with the focus being on the thermodynamics of mirror waves. A set of double-polytropic (DP) laws are adopted to infer the corresponding thermodynamic conditions characterized by the polytropic exponents, γ⊥and γ. It is shown that the γ⊥, values at the saturation stages are in the ranges of γ⊥ = 0.64±0.21 and γ = 1.07±0.12 which are consistent with the observations and linear kinetic theory (Hau et al. 2021). The saturated plasma β are well fitted by the modified DP MHD mirror condition of γβ = β⊥2/(2+γ⊥β⊥) with γ⊥ ≈ 0.8, γ ≈ 1.3 which may be used as a new mirror criterion for the mirror waves observed in the solar system.

Silica particles are widely used as a support material for chemically-bound stationary phases in chromatographic separation processes. The tuning of textural properties and surface chemistry of stationary phase materials (SPMs) is crucial to enhance their selectivity to certain compounds and the efficiency of the separation process. Silica supports have the advantage that their surface can be modified with a large variety of hydrophilic and hydrophobic functional groups, but their influence on the silica surface properties has not been evaluated in detail. In this sense, the contact angle is a key parameter for the assessment of surface chemistry but its quantification in the pore walls is particularly challenging and requires a combination of various tools and experimental techniques. In this work we demonstrate that by combining water adsorption and intrusion measurements is possible to derive reliable information of the effective contact angle θ of adsorbed water for wetting (θ = 0°), partial wetting (θ < 90°), and non-wetting situations (θ > 90°) observed on the pore walls of the SPMs under study. Furthermore, NMR relaxometry experiments reveal that the T1,ads.film/T2,ads.film-ratio can be correlated with the effective adsorption strength of water on the surface. Indeed, we find a linear correlation between the negative inverse of the T1,ads.film/T2,ads.film -ratio (-T2,ads.film/T1,ads.film) with the contact angle determined from water vapor adsorption and intrusion experiments for the investigated SPMs. Our work clearly demonstrates for the first time that water vapor adsorption experiments and novel water intrusion technique coupled with NMR relaxometry can be used as complementary techniques to quantitatively analyze the wettability behavior and surface chemistry of nanoporous materials.

(1) Background: Betel nut chewing injures bodily health. Although, the relationship between betel nut chewing and kidney stone disease (KSD) is unknown. (2) Methods: We analyzed 43,636 men from Taiwan Biobank. We divided them into two groups on the status of betel nut chewing, the never-chewer and ever-chewer groups. Self-reported diagnosed KSD was defined as the subject’s medical history of KSD in the questionnaire. Logistic regression was used to analyze the association of betel nut chewing and the risk of KSD. (3) Results: The mean age of subjects in the present study was 50 years, and 16% were ever-chewers. KSD was observed in 3759 (10.3%) and 894 (12.6%) participants in the group of never-chewer and ever-chewer groups, respectively. Higher risk of KSD was found in participants with betel nut chewing compared with to without betel nut chewing (odds ratio (OR), 1.094; 95% confidence interval (95% CI), 1.001 to 1.196). Furthermore, the daily amounts of betel nut chewing >30 quids was associated with a more than 1.5-fold increase (OR, 1.571; 95% CI, 1.186 to 2.079) in the odds of KSD; (4) Conclusions: Our study suggests that betel nut chewing is associated with the risk of KSD and warrants further attention to this problem.

Programming logic controllers (PLCs) are vital components for conveyors in production lines, and the sensors and actuators controlled underneath the PLCs represent critical points in the manufacturing process. Attacks targeting the exploitation of PLC vulnerabilities have been on the rise recently. In this study, a PLC test platform aims to analyze the vulnerabilities of a typical industrial setup and perform cyberattack exercises to review the system cybersecurity challenges. The PLC test platform is a sorting machine consisting of an automatic conveyor belt, two Mitsubishi FX5U-32M PLCs, and accessories for material sorting, and Modbus is the selected protocol for data communication. The O.S. on the attacker is Kali ver. 2022.3, runs Nmap and Metasploit to exploit the target Modbus registers. On the other hand, the target host runs the O.S., Ubuntu 22.04 in the cyberattack exercises. The selected attack method for this study is packet reply which can halt operations sending custom data packets to the PLC. In summary, this study provides a basic step-by-step offensive strategy targeting register modification, and the testbed represents a typical industrial environment and its vulnerabilities against cyberattacks with common open-source tools.

Introduction: Fluoroquinolone exposure is reportedly associated with a higher risk of tendon disorders, tendonitis, or tendon rupture. However, studies in East Asian populations have not confirmed these risks in patients with comorbidities or concomitant medication use. This cohort study was designed to investigate the associations among fluoroquinolone exposure, comorbidities, medication use, and tendon disorders in Taiwan.Materials and Methods: This population-based, nationwide, observational, cohort study used data from the National Health Insurance Research database in Taiwan, a nationwide claims database that covers more than 99% of the Taiwanese population. The study period was from January 2000 to December 2015, and the median follow-up time was 11.05 ± 10.91 years. Patients who were exposed to fluoroquinolones for more than three consecutive days were enrolled, and patients without fluoroquinolone exposure who were matched by age, sex, and index year were enrolled as controls. The associations of comorbidities and concomitant medication use with tendon disorder occurrence were analyzed using Cox regression models.Results: The incidence of tendon disorders were 6.61 and 3.34 per 105 person-years in patients with and without fluoroquinolone exposure, respectively (adjusted hazard ratio, 1.423; 95% confidence interval [1.02,1.87]; p = 0.021). Sensitivity analyses yielded similar results. Patients under 18 and over 60 years with fluoroquinolone exposure; those with chronic kidney disease, diabetes, rheumatologic disease, cardiac disease, lipid disorder, or obesity; and those who concomitantly used statins, aromatase inhibitors, or glucocorticoids, had a significantly higher risk of tendon disorders.Conclusion: The long-term risk of tendon disorders was higher in patients with fluoroquinolone exposure than in those without fluoroquinolone exposure. Clinicians should assess the benefits and risks of fluoroquinolone use in patients at high risk of tendon disorders who require fluoroquinolone administration.

Mirror-mode waves driven by the large temperature anisotropy of T ⊥/T ∣∣ > 1 have been widely observed in the solar wind, planetary magnetosheaths, heliosheath, etc. Recent studies have shown that the phase relations and thermodynamics of the mirror waves observed in the terrestrial magnetosheath may well be interpreted by the linear mixed kinetic–MHD theory of proton mirror instability. In particular, the energy laws possess the form of double-polytropic closures with the thermodynamic exponents being functions of β ⊥,∣∣ = p ⊥,∣∣/(B 2/2μ 0). In this study, we examine the time evolution of proton mirror instability based on the hybrid particle simulations for twenty sets of β ⊥,∣∣ values. Quantitative comparisons between the kinetic simulations, linear Vlasov theory, and observations are made in terms of the growth rates, phase relations, thermodynamic conditions, etc., which show high agreements. In particular, the dependences of various compressibility and thermodynamic exponents on β ⊥,∣∣ are confirmed by the kinetic simulations, which show that the polytropic exponents are in the ranges of γ ⊥ = 0.64 ± 0.21, and γ ∣∣ = 1.07 ± 0.12 consistent with the theoretical predictions and mirror observations of γ ⊥ < 1 and γ ∣∣ ≳ 1. It is shown that the observed features, including the various perturbations and wavelengths, may indeed be reproduced by the nonlinear simulations. The saturated temperature anisotropy β ⊥/β ∣∣ and plasma β ∣∣ show an anticorrelation, which may well be fitted by the modified mirror instability threshold of γ ∣ ∣ β ∣ ∣ = β ⊥ 2 / 2 + γ ⊥ β ⊥ with γ ⊥ ≈ 0.8, γ ∣∣ ≈ 1.3, and the saturated magnetic field of δ B/B ≈ 0.26 ∼ 0.97 increases with increasing values of β ≈ 1.6 ∼ 8.3.