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A study conducted at the Second Affiliated Hospital of Chongqing Medical University in China explored the use of 131I and/or artificial liver support system (ALSS) in managing hyperthyroidism and liver failure. The research involved 74 patients with severe liver failure due to Graves' disease, divided into three groups receiving different treatments. Results showed that combining 131I and ALSS led to better outcomes in terms of thyroid and liver function compared to using ALSS alone. The study recommended prompt administration of 131I in cases of severe liver failure with hyperthyroidism to improve liver function and reduce mortality rates. [Extracted from the article]

A recent report from the Engineering Research Center discusses the use of three-dimensional (3D) bioprinting technology to create bioartificial livers. The researchers used in vitro-expanded primary hepatocytes, known for their safety and enhanced functionality, as the cell source for the bioartificial liver. The 3D-bioprinted liver was able to restore lost liver functions when transplanted into mice with liver injuries, extending their lifespan. The inclusion of an artificial blood vessel allowed for biomolecule exchange with host blood vessels, demonstrating the potential for rapid integration of the bioartificial liver into the host vascular system. This research highlights the therapeutic potential of transplantation for the treatment of liver failure diseases. [Extracted from the article]

A recent report from the National Key Laboratory of Biochemical Engineering in Beijing, China, discusses the development of a novel scaffold material called PET-COL for bioartificial livers. The researchers modified polyethylene terephthalate (PET) with collagen to enhance the material's hydrophilicity. They conducted various tests to characterize the physicochemical and biological properties of the scaffold, and found that it supported the growth and vitality of human liver progenitor cells. The study concludes that the PET-COL scaffold shows great potential for use in bioartificial livers. [Extracted from the article]

A study conducted by the University of the Chinese Academy of Sciences in Shanghai, China, explores the potential of liver cell therapy as an alternative to liver transplantation for patients with liver failure and hereditary liver diseases. The scarcity of human hepatocytes has limited the clinical implementation of this therapy. The study reviews strategies to generate functional human hepatocytes and discusses their potential applications in hepatocyte transplantation and bioartificial liver transplantation. The researchers also highlight new delivery methods to improve hepatocyte engraftment and discuss potential future directions. [Extracted from the article]

Researchers from Southern Medical University Zhujiang Hospital in Guangzhou, China have developed a patent-pending bio-artificial liver support system. This system aims to address the limitations of liver transplantation by providing a comprehensive solution for patients with severe liver failure. The system consists of multiple branch tubes that perform specific functions, such as plasma separation and purification. By controlling the different branch tubes, the system can be customized to meet the needs of individual patients. [Extracted from the article]

Researchers at the Chinese Academy of Medical Sciences have developed a new method for creating bioartificial livers, known as rapid self-assembly mini-livers (RSALs), which can be generated within 12 hours. These RSALs are larger in size, have improved cell viability, and enhanced liver functionality compared to existing methods. When transplanted into mice, the RSALs effectively protected the mice from liver failure induced by hepatectomy. This study demonstrates the potential of bioartificial liver-based therapy for the treatment of liver diseases and conditions. [Extracted from the article]

Researchers from Shanxi Medical University in China have developed a machine learning model to predict the prognosis of liver failure patients treated with non-bioartificial liver support systems. The study analyzed 215 patients and identified several independent factors that contribute to short-term prognosis, including etiology, hepatic encephalopathy, total bilirubin, serum alkaline phosphatase, platelets, and MELD score. The Random Survival Forests (RSF) model performed better in predicting prognosis compared to the Nomogram model and MELD score. This research could help physicians make more informed treatment decisions for liver failure patients. [Extracted from the article]

A patent has been issued for a combined bio-artificial liver support system developed by inventors from Southern Medical University Zhujiang Hospital in China. The system aims to address the limitations of liver transplantation, such as scarcity of donors and rejection by the immune system, by providing a comprehensive solution for patients with severe liver failure. The system consists of multiple branch tubes connected in sequence, including a blood input branch tube, plasma separation branch tube, non-biological purification branch tube, biological purification branch tube, and plasma return branch tube. The invention allows for the switching of multiple functions and has the potential to extend the life of patients and improve their quality of life. [Extracted from the article]

Researchers from the Polish Academy of Sciences have developed a model of a bioartificial liver using a hollow fiber bioreactor populated with genetically modified hepatic cells. This model aims to improve the development of bioartificial liver devices and potentially contribute to the treatment of patients with impaired liver function. The study compared the culturing of hepatic cells in both static and dynamic conditions and analyzed parameters such as cell viability, glucose consumption, albumin secretion, and urea production. The limited availability of transplantable organs has led to the exploration of alternative therapies, including bioartificial livers, for chronic liver disease and cirrhosis. [Extracted from the article]

A recent study conducted at the First Affiliated Hospital of Kunming Medical University in China explored the efficacy and safety of a small-volume-plasma artificial liver support system (ALSS) in the treatment of acute-on-chronic liver failure (ACLF). The study compared the outcomes of ACLF patients who received ALSS treatment with small-volume plasma and half-volume plasma. The results showed no significant difference in survival rates between the two groups, indicating that the small-volume-plasma ALSS treatment is effective and safe. This approach also reduces the need for intraoperative plasma, which is particularly beneficial during plasma shortages. [Extracted from the article]

A recent study conducted at the Second Affiliated Hospital of Kunming Medical University examined the influence of different diagnostic criteria on the short-term prognosis of patients with acute-on-chronic liver failure (ACLF) who received artificial liver therapy. The study compared three different guidelines for liver failure diagnosis and treatment: the Chinese Medical Association (CMA) guideline, the Asian Pacific Association for the Study of the Liver (APASL) guideline, and the European Association for the Study of the Liver (EASL) guideline. The results showed that ACLF patients who met the EASL guideline had a higher 90-day mortality rate compared to those who met the CMA and APASL guidelines. The EASL guideline was found to have a sensitivity of 22.2% and a specificity of 92.3% in predicting the risk of short-term mortality. The study suggests that the EASL guideline may help identify ACLF patients at a higher risk of short-term death. [Extracted from the article]

A study conducted at Zhejiang University explored the characteristics of circulating immune cells in patients with HBV-related acute-on-chronic liver failure (HBV-ACLF) before and after treatment with an artificial liver support system (ALSS). The study found that changes in certain immune cells, such as effector CD8+ T cells, effector and memory CD4+ T cells, and inhibitory natural killer (NK) cells, were associated with ALSS treatment. Additionally, the study observed differences in the proportions of monocytes and gdT cells between patients who improved and those who did not. These findings suggest that the phenotypic heterogeneity of immune cells may play a role in the prognosis of ALSS and future immunotherapy strategies for HBV-ACLF. [Extracted from the article]

A recent study on gene therapy has explored the potential for innovative therapies targeting liver fibrogenesis. Liver fibrosis, which can lead to cirrhosis and liver failure, currently has limited treatment options. The study highlights various emerging approaches, including artificial liver support, stem cell therapy, cell/gene therapy, nanomedicines, immunotherapy, and herbal medicines, that have shown promise in inhibiting liver fibrogenesis or stimulating regeneration. However, despite encouraging preclinical data, these therapies face challenges in safety, delivery, and efficacy, and further optimization and clinical evaluation are needed. Combination treatment regimens may offer the most effective approach. [Extracted from the article]

A patent has been issued for a perfusion bioreactor, perfusion device, artificial liver system, and related methods. The patent describes a system that aims to treat acute liver failure by providing temporary liver function while the patient's liver regenerates. The system includes a housing with perfusion devices that contain encapsulated organ tissue, allowing for the exchange of solutes between the patient's blood and the artificial liver cells. The invention addresses limitations of current extracorporeal systems and cell-based dialysis systems. The patent was filed by Morphocell Technologies Inc. and published online on November 7, 2023. [Extracted from the article]

Keywords: Artificial Livers; Bioengineering; Biomedical Engineering; Biomedicine; Biotechnology; Endocrine System Diseases and Conditions; Gastroenterology; Health and Medicine; Hepatology; Hyperthyroidism; Liver Diseases and Conditions; Liver Function; Medical Devices; Organ Transplants; Thyroid Diseases and Conditions EN Artificial Livers Bioengineering Biomedical Engineering Biomedicine Biotechnology Endocrine System Diseases and Conditions Gastroenterology Health and Medicine Hepatology Hyperthyroidism Liver Diseases and Conditions Liver Function Medical Devices Organ Transplants Thyroid Diseases and Conditions 326 326 1 09/25/23 20230926 NES 230926 2023 SEP 28 (NewsRx) -- By a News Reporter-Staff News Editor at Gastroenterology Week -- Fresh data on artificial livers are presented in a new report. Artificial Livers, Bioengineering, Biomedical Engineering, Biomedicine, Biotechnology, Endocrine System Diseases and Conditions, Gastroenterology, Health and Medicine, Hepatology, Hyperthyroidism, Liver Diseases and Conditions, Medical Devices, Organ Transplants, Thyroid Diseases and Conditions, Liver Function. [Extracted from the article]

Keywords: Aminotransferase; Artificial Livers; Bioengineering; Biomedical Engineering; Biomedicine; Biotechnology; DNA Viruses; Digestive System Diseases and Conditions; Enzymes and Coenzymes; Gastroenterology; Health and Medicine; Hepadnaviridae; Hepadnaviridae Infections; Hepatic Insufficiency; Hepatitis B Virus; Hepatology; Liver Diseases and Conditions; Liver Failure; Medical Devices; Organ Transplants; Orthohepadnavirus; Risk and Prevention; Therapy; Viral EN Aminotransferase Artificial Livers Bioengineering Biomedical Engineering Biomedicine Biotechnology DNA Viruses Digestive System Diseases and Conditions Enzymes and Coenzymes Gastroenterology Health and Medicine Hepadnaviridae Hepadnaviridae Infections Hepatic Insufficiency Hepatitis B Virus Hepatology Liver Diseases and Conditions Liver Failure Medical Devices Organ Transplants Orthohepadnavirus Risk and Prevention Therapy Viral 486 486 1 09/11/23 20230915 NES 230915 2023 SEP 14 (NewsRx) -- By a News Reporter-Staff News Editor at Hepatitis Weekly -- Researchers detail new data in artificial livers. In this study, 109 stool samples were collected from patients with hepatitis B virus-associated acute chronic liver failure (HBV-ACLF) for 16S rRNA sequencing. [Extracted from the article]

The artificial liver construct of claim 1, wherein said hepatocyte cells, said Kupffer cells, said hepatic stellate cells, and said cholangiocyte cells are mammalian cells. Supplementing the background information on this patent, NewsRx reporters also obtained the inventors' summary information for this patent: "According to some embodiments, cell compositions useful for making artificial liver constructs may include, in combination,: (a) hepatocyte cells, (b) Kuppfer cells, (c) hepatic stellate cells, (d) sinusoidal endothelial cells, and (e) cholangiocyte cells. Keywords: Artificial Livers; Bioengineering; Biomedical Engineering; Biomedicine; Biotechnology; Cellular Structures; Emerging Technologies; Endothelial Cells; Extracellular Matrix; Extracellular Space; Gastroenterology; Health and Medicine; Hepatic Stellate Cells; Hepatocytes; Medical Devices; Microfabrication; Nanotechnology; Organ Transplants; Wake Forest University Health Sciences EN Artificial Livers Bioengineering Biomedical Engineering Biomedicine Biotechnology Cellular Structures Emerging Technologies Endothelial Cells Extracellular Matrix Extracellular Space Gastroenterology Health and Medicine Hepatic Stellate Cells Hepatocytes Medical Devices Microfabrication Nanotechnology Organ Transplants Wake Forest University Health Sciences 894 894 1 09/11/23 20230914 NES 230914 2023 SEP 14 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- Wake Forest University Health Sciences (Winston-Salem, North Carolina, United States) has been issued patent number 11732241, according to news reporting originating out of Alexandria, Virginia, by NewsRx editors. [Extracted from the article]

Keywords for this news article include: Chongqing, People's Republic of China, Asia, Artificial Livers, Bioengineering, Biomedical Engineering, Biomedicine, Biotechnology, Clinical Research, Clinical Trials and Studies, Gastroenterology, Health and Medicine, Hepatic Insufficiency, Hepatology, Liver Diseases and Conditions, Liver Failure, Medical Devices, Organ Transplants, Risk and Prevention, Chongqing Medical University. Chongqing, People's Republic of China, Asia, Artificial Livers, Bioengineering, Biomedical Engineering, Biomedicine, Biotechnology, Clinical Research, Clinical Trials and Studies, Gastroenterology, Health and Medicine, Hepatic Insufficiency, Hepatology, Liver Diseases and Conditions, Liver Failure, Medical Devices, Organ Transplants, Risk and Prevention Keywords: Chongqing; People's Republic of China; Asia; Artificial Livers; Bioengineering; Biomedical Engineering; Biomedicine; Biotechnology; Clinical Research; Clinical Trials and Studies; Gastroenterology; Health and Medicine; Hepatic Insufficiency; Hepatology; Liver Diseases and Conditions; Liver Failure; Medical Devices; Organ Transplants; Risk and Prevention EN Chongqing People's Republic of China Asia Artificial Livers Bioengineering Biomedical Engineering Biomedicine Biotechnology Clinical Research Clinical Trials and Studies Gastroenterology Health and Medicine Hepatic Insufficiency Hepatology Liver Diseases and Conditions Liver Failure Medical Devices Organ Transplants Risk and Prevention 600 600 1 09/11/23 20230911 NES 230911 2023 SEP 14 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Fresh data on Biomedical Engineering - Artificial Livers are presented in a new report. [Extracted from the article]

Pneumonia refer to the diagnostic criteria of the American Society of Infectious Diseases/American Thoracic Society for adult severe pneumonia in 2007), abdominal infection (after reasonable antibiotic treatment, there are still Peritonitis manifestations or white blood cells in ascites 0.1 x 10 9/L), etc. Keywords: Artificial Livers; Bioengineering; Biomedical Engineering; Biomedical Engineering - Artificial Livers; Biomedicine; Biotechnology; Clinical Research; Clinical Trials and Studies; Drugs and Therapies; Gastroenterology; Health and Medicine; Hepatic Insufficiency; Hepatology; Infectious Disease; Liver Diseases and Conditions; Liver Failure; Lung Diseases and Conditions; Medical Devices; Organ Transplants; Pneumonia; Pulmonology; Respiratory Tract Diseases and Conditions; Respiratory Tract Infections; Risk and Prevention EN Artificial Livers Bioengineering Biomedical Engineering Biomedical Engineering - Artificial Livers Biomedicine Biotechnology Clinical Research Clinical Trials and Studies Drugs and Therapies Gastroenterology Health and Medicine Hepatic Insufficiency Hepatology Infectious Disease Liver Diseases and Conditions Liver Failure Lung Diseases and Conditions Medical Devices Organ Transplants Pneumonia Pulmonology Respiratory Tract Diseases and Conditions Respiratory Tract Infections Risk and Prevention 60 60 1 08/28/23 20230829 NES 230829 2023 AUG 31 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Staff editors report on the newly launched clinical trial, NCT05989958, which has the following summary description: "This is a multicenter, randomized, controlled, open-label phase 1/2 clinical study conducted in China to evaluate the efficacy, safety and tolerability of hiHep cell-based bio-artificial liver support system (HepaCure) plus DPMAS versus DPMAS alone in Chinese subjects with acute-on-chronic liver failure(ACLF). [Extracted from the article]

Notably, an investigator-initiated study in seven patients with extended liver resection demonstrated that hiHep-BAL treatment was well tolerated and associated with improved liver function and liver regeneration, meeting the primary outcome of safety and feasibility." Keywords: Hangzhou; People's Republic of China; Asia; Artificial Livers; Artificial Organs; Bioartificial Livers; Bioengineering; Biomedical Engineering; Biomedicine; Biotechnology; Gastroenterology; Health and Medicine; Hepatic Insufficiency; Hepatology; Liver Diseases and Conditions; Liver Failure; Liver Regeneration; Liver Resection; Surgery; Tissue Engineering EN Hangzhou People's Republic of China Asia Artificial Livers Artificial Organs Bioartificial Livers Bioengineering Biomedical Engineering Biomedicine Biotechnology Gastroenterology Health and Medicine Hepatic Insufficiency Hepatology Liver Diseases and Conditions Liver Failure Liver Regeneration Liver Resection Surgery Tissue Engineering 146 146 1 07/17/23 20230720 NES 230720 2023 JUL 20 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- Current study results on Biomedical Engineering - Bioartificial Livers have been published. [Extracted from the article]

Keywords: Guangdong; People's Republic of China; Asia; Acute Liver Failure; Apoptosis; Artificial Livers; Artificial Organs; Bioartificial Livers; Bioengineering; Biomedical Engineering; Biomedicine; Biotechnology; Cellular Physiology; Gastroenterology; Health and Medicine; Hepatic Insufficiency; Hepatology; Liver Diseases and Conditions; Liver Failure EN Guangdong People's Republic of China Asia Acute Liver Failure Apoptosis Artificial Livers Artificial Organs Bioartificial Livers Bioengineering Biomedical Engineering Biomedicine Biotechnology Cellular Physiology Gastroenterology Health and Medicine Hepatic Insufficiency Hepatology Liver Diseases and Conditions Liver Failure 137 137 1 07/03/23 20230707 NES 230707 2023 JUL 6 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on Biomedical Engineering - Bioartificial Livers have been published. Guangdong, People's Republic of China, Asia, Acute Liver Failure, Apoptosis, Artificial Livers, Bioartificial Livers, Bioengineering, Biomedical Engineering, Biomedicine, Biotechnology, Cellular Physiology, Gastroenterology, Health and Medicine, Hepatic Insufficiency, Artificial Organs, Hepatology, Liver Diseases and Conditions, Liver Failure. [Extracted from the article]

Artificial Livers, Bioengineering, Biomedical Engineering, Biomedicine, Biotechnology, Critical Care Medicine, Dehydrogenase, Enzymes and Coenzymes, Gastroenterology, Health and Medicine, Hepatology, Intensive Care Medicine, Hepatic Insufficiency, Liver Diseases and Conditions, Liver Failure, Medical Devices, Organ Transplants Keywords: Artificial Livers; Bioengineering; Biomedical Engineering; Biomedicine; Biotechnology; Critical Care Medicine; Dehydrogenase; Enzymes and Coenzymes; Gastroenterology; Health and Medicine; Hepatic Insufficiency; Hepatology; Intensive Care Medicine; Liver Diseases and Conditions; Liver Failure; Medical Devices; Organ Transplants EN Artificial Livers Bioengineering Biomedical Engineering Biomedicine Biotechnology Critical Care Medicine Dehydrogenase Enzymes and Coenzymes Gastroenterology Health and Medicine Hepatic Insufficiency Hepatology Intensive Care Medicine Liver Diseases and Conditions Liver Failure Medical Devices Organ Transplants 49 49 1 04/10/23 20230413 NES 230413 2023 APR 13 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- Investigators publish new report on artificial livers. [Extracted from the article]

For more information on this research see: Value of total bilirubin rebound rate and total bilirubin clearance rate in evaluating the prognosis of severe drug-induced liver injury after artificial liver support therapy. Keywords: Artificial Livers; Bile Pigments; Bilirubin; Bioengineering; Biological Factors; Biomedical Engineering; Biomedicine; Biotechnology; Digestive System Diseases and Conditions; Drug-Induced Liver Injury; Drugs and Therapies; Health and Medicine; Hospitals; Liver Diseases and Conditions; Medical Devices; Organ Transplants; Therapy EN Artificial Livers Bile Pigments Bilirubin Bioengineering Biological Factors Biomedical Engineering Biomedicine Biotechnology Digestive System Diseases and Conditions Drug-Induced Liver Injury Drugs and Therapies Health and Medicine Hospitals Liver Diseases and Conditions Medical Devices Organ Transplants Therapy 384 384 1 04/10/23 20230414 NES 230414 2023 APR 13 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Fresh data on artificial livers are presented in a new report. [Extracted from the article]

For more information on this research see: Value of a risk assessment model in predicting venous thromboembolism in patients with liver failure after artificial liver support therapy. Keywords: Artificial Livers; Bioengineering; Biomedical Engineering; Biomedicine; Biotechnology; Cardiovascular Diseases and Conditions; Embolism and Thrombosis; Gastroenterology; Health and Medicine; Hematology; Hepatic Insufficiency; Hepatology; Liver Diseases and Conditions; Liver Failure; Medical Devices; Organ Transplants; Risk and Prevention; Thromboembolism; Vascular Diseases and Conditions; Venous Thromboembolism EN Artificial Livers Bioengineering Biomedical Engineering Biomedicine Biotechnology Cardiovascular Diseases and Conditions Embolism and Thrombosis Gastroenterology Health and Medicine Hematology Hepatic Insufficiency Hepatology Liver Diseases and Conditions Liver Failure Medical Devices Organ Transplants Risk and Prevention Thromboembolism Vascular Diseases and Conditions Venous Thromboembolism 437 437 1 04/10/23 20230413 NES 230413 2023 APR 13 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Investigators discuss new findings in artificial livers. [Extracted from the article]

For more information on this research see: A multi-subgroup predictive model based on clinical parameters and laboratory biomarkers to predict in-hospital outcomes of plasma exchange-centered artificial liver treatment in patients with hepatitis B virus-related acute-on-chronic liver failure. Keywords: Artificial Livers; Bioengineering; Biomarkers; Biomedical Engineering; Biomedicine; Biotechnology; Blood Transfusion; DNA Viruses; Diagnostics and Screening; Digestive System Diseases and Conditions; Gastroenterology; Health and Medicine; Hepadnaviridae; Hepadnaviridae Infections; Hepatic Insufficiency; Hepatitis; Hepatitis B Virus; Hepatology; Hospitals; Infectious Diseases and Conditions; Liver Diseases and Conditions; Liver Failure; Medical Devices; Organ Transplants; Orthohepadnavirus; Plasma Exchange; Plasmapheresis; Risk and Prevention; Viral; Virology EN Artificial Livers Bioengineering Biomarkers Biomedical Engineering Biomedicine Biotechnology Blood Transfusion DNA Viruses Diagnostics and Screening Digestive System Diseases and Conditions Gastroenterology Health and Medicine Hepadnaviridae Hepadnaviridae Infections Hepatic Insufficiency Hepatitis Hepatitis B Virus Hepatology Hospitals Infectious Diseases and Conditions Liver Diseases and Conditions Liver Failure Medical Devices Organ Transplants Orthohepadnavirus Plasma Exchange Plasmapheresis Risk and Prevention Viral Virology 319 319 1 04/03/23 20230407 NES 230407 2023 APR 6 (NewsRx) -- By a News Reporter-Staff News Editor at Hepatitis Weekly -- New study results on artificial livers have been published. [Extracted from the article]

Keywords for this news article include: University Indonesia, Jakarta, Indonesia, Asia, Biotechnology, Tissue Engineering, Biomedical Engineering, Biomedicine, Therapy, Hepatology, Liver Failure, Bioengineering, Medical Devices, Gastroenterology, Artificial Livers, Organ Transplants, Health and Medicine, Hepatic Insufficiency, Liver Diseases and Conditions. Keywords: Artificial Livers; Bioengineering; Biomedical Engineering; Biomedicine; Biotechnology; Gastroenterology; Health and Medicine; Hepatic Insufficiency; Hepatology; Liver Diseases and Conditions; Liver Failure; Medical Devices; Organ Transplants; Therapy; Tissue Engineering EN Artificial Livers Bioengineering Biomedical Engineering Biomedicine Biotechnology Gastroenterology Health and Medicine Hepatic Insufficiency Hepatology Liver Diseases and Conditions Liver Failure Medical Devices Organ Transplants Therapy Tissue Engineering 146 146 1 03/24/23 20230302 NES 230302 2023 MAR 2 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- Investigators discuss new findings in artificial livers. Artificial Livers, Bioengineering, Biomedical Engineering, Biomedicine, Biotechnology, Gastroenterology, Health and Medicine, Hepatic Insufficiency, Liver Diseases and Conditions, Liver Failure, Medical Devices, Organ Transplants, Therapy, Tissue Engineering, Hepatology. [Extracted from the article]