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Your search keyword '"Andreas Stumpf"' showing total 4 results
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4 results on '"Andreas Stumpf"'

2. Synthesis of 3-Aryl-Substituted 4-Aminopyrazoles from Acetophenones

Author

Andreas Stumpf, Di Xu, Tyler A. Tuck, and Haiming Zhang

Subjects
Organic Chemistry, Catalysis
Abstract

A synthetic methodology for a protecting-group-free formation of 3-aryl-substituted 4-aminopyrazoles from acetophenones via a telescoped oximation and hydrazine condensation of 1,3-ketoaldehydes to generate nitrosopyrazoles, and copper-catalyzed NaBH4 reduction of the nitroso group, was demonstrated. The synthesis tolerates a broad scope of substrates with a variety of substituents on the phenyl ring to afford the desired products.

Published
2022
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4. Guided optimization of a crystallization-induced diastereomer transformation to access a key navoximod intermediate

Author

Andrew J. Kukor, Frédéric St-Jean, Andreas Stumpf, Thomas C. Malig, Katarzyna A. Piechowicz, Kenji Kurita, and Jason E. Hein

Subjects
Fluid Flow and Transfer Processes, Chemistry (miscellaneous), Process Chemistry and Technology, Chemical Engineering (miscellaneous), Catalysis
Abstract

The crystallization-induced diastereomer transformation of a precursor to navoximod was investigated using online HPLC and optimized with inline racemization.

Published
2023
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