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5 results on '"Aldo Zagami"'

1. Corynebacterium striatum Bacteremia during SARS-CoV2 Infection: Case Report, Literature Review, and Clinical Considerations

Author

Andrea Marino, Edoardo Campanella, Stefano Stracquadanio, Manuela Ceccarelli, Aldo Zagami, Giuseppe Nunnari, and Bruno Cacopardo

Subjects
Corynebacterium striatum, Corynebacterial infections, Corynebacterial bacteremia, Other systems of medicine, RZ201-999
Abstract

Bacterial infections, especially those in hospital settings, represent a major complication of COVID-19 patients, complicating management and worsening clinical outcomes. Corynebacterium striatum is a non-diphtheric actinobacterium that has been reported as being the causative agent of several different infections, affecting both immunocompetent and immunocompromised patients. Recently, C. striatum has been recognized as a nosocomial pathogen that is responsible for severe infection in critical patients, as well as in fragile and immunocompromised subjects. C. striatum has been described as the etiological agent of bacteremia, central line infections, and endocarditis. We report a case of a 91-year-old woman who was hospitalized due to SARS-CoV-2 infection, who developed C. striatum bacteremia and died despite antimicrobial therapy and clinical efforts. Furthermore, we discuss C. striatum diagnosis and treatment based on evidence from the scientific literature.

Published
2022
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2. Ampicillin plus ceftriaxone therapy against Enterococcus faecalis endocarditis: A case report, guidelines considerations, and literature review

Author

Andrea Marino, Antonio Munafò, Aldo Zagami, Manuela Ceccarelli, Edoardo Campanella, Federica Cosentino, Vittoria Moscatt, Giuseppina Cantarella, Rosaria Di Mauro, Renato Bernardini, Giuseppe Nunnari, and Bruno Cacopardo

Subjects
Infective endocarditis, Enterococcus faecalis, Double beta-lactams therapy, Ampicillin plus ceftriaxone, Antibiotics resistance, Infectious and parasitic diseases, RC109-216
Abstract

Enterococcus faecalis infective endocarditis (EFIE) continues to be a very serious disease, showing considerable morbidity and mortality rates which are influenced by the spread of multi-drug resistant strains occurred in the last decades. Although aminoglycosides were considered the treatment of choice of EIFE, in recent years several studies have investigated alternative therapeutic approaches, including combinations of beta-lactams, mainly because of the aminoglycoside-renowned nephrotoxicity and the widespread development of high-level aminoglycosides resistance (HLAR). In this scenario, we reported a case involving a prosthetic valve infective endocarditis caused by an aminoglycoside-resistant E. faecalis strain which was successfully treated with ampicillin plus ceftriaxone despite the presence of artificial heart valve and the patient’s severe clinical conditions.

Published
2022
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3. Oral fosfomycin formulation for acute bacterial prostatitis; a new role for an old molecule: A case report and brief literature review

Author

Andrea Marino, Stefano Stracquadanio, Manuela Ceccarelli, Aldo Zagami, Giuseppe Nunnari, and Bruno Cacopardo

Subjects
General Immunology and Microbiology, acute bacterial prostatitis, fosfomycin‑trometamol, Escherichia coli prostatitis, Escherichia coli prostatitis, acute bacterial prostatitis, fosfomycin‑trometamol, General Biochemistry, Genetics and Molecular Biology
Published
2022

4. Clinical characteristics and predictors of death among hospitalized patients infected with SARS‑CoV‑2 in Sicily, Italy: A retrospective observational study

Author

Federica Cosentino, Vittoria Moscatt, Andrea Marino, Alessio Pampaloni, Daniele Scuderi, Manuela Ceccarelli, Francesco Benanti, Maria Gussio, Licia Larocca, Vincenzo Boscia, Giovanni Vinci, Aldo Zagami, Anna Onorante, Gaetano Lupo, Salvatore Torrisi, Silvana Grasso, Roberto Bruno, Carmelo Iacobello, Salvatore Bonfante, Luigi Guarneri, Antonio Cascio, Antonella Franco, Rossella Del Vecchio, Maria Di Rosolini, Alfredo Pulvirenti, Damiano Larnè, Giuseppe Nunnari, Benedetto Celesia, Bruno Cacopardo, Cosentino, Federica, Moscatt, Vittoria, Marino, Andrea, Pampaloni, Alessio, Scuderi, Daniele, Ceccarelli, Manuela, Benanti, Francesco, Gussio, Maria, Larocca, Licia, Boscia, Vincenzo, Vinci, Giovanni, Zagami, Aldo, Onorante, Anna, Lupo, Gaetano, Torrisi, Salvatore, Grasso, Silvana, Bruno, Roberto, Iacobello, Carmelo, Bonfante, Salvatore, Guarneri, Luigi, Cascio, Antonio, Franco, Antonella, Del Vecchio, Rossella Fontana, Di Rosolini, Maria Antonietta, Pulvirenti, Alfredo, Larnè, Damiano, Nunnari, Giuseppe, Celesia, Benedetto Maurizio, and Cacopardo, Bruno

Subjects
predictors of death, SARS-CoV-2, General Neuroscience, pandemic, epidemiological features, General Medicine, General Pharmacology, Toxicology and Pharmaceutics, epidemiological feature, SARS-CoV-2, pandemic, epidemiological features, predictors of death, General Biochemistry, Genetics and Molecular Biology
Abstract

Since late December 2019, severe acute respiratory syndrome coronavirus 2 has spread across the world, which resulted in the World Health Organization declaring a global pandemic. Coronavirus disease 2019 (COVID-19) presents a highly variable spectrum with regard to the severity of illness. Most infected individuals exhibit a mild to moderate illness (81%); however, 14% have a serious disease and 5% develop severe acute respiratory distress syndrome (ARDS), requiring intensive care support. The mortality rate of COVID-19 continues to rise across the world. Data regarding predictors of mortality in patients with COVID 19 are still scarce but are being actively investigated. The present multicenter retrospective observational study provides a complete description of the demographic and clinical characteristics, comorbidities and laboratory abnormalities in a population of 421 hospitalized patients recruited across eight infectious disease units in Southern Italy (Sicily) with the aim of identifying the baseline characteristics predisposing COVID-19 patients to critical illness or death. In this study, older age, pre-existing comorbidities and certain changes in laboratory markers (such as neutrophilia, lymphocytopenia and increased C-reactive protein levels) at the time of admission were associated with a higher risk of mortality. Male sex, on the other hand, was not significantly associated with increased risk of mortality. Symptoms such as fatigue, older age, a number of co-pathologies and use of continuous positive airway pressure were the most significant contributors in the estimation of clinical prognosis. Further research is required to better characterize the epidemiological features of COVID-19, to understand the related predictors of death and to develop new effective therapeutic strategies.

Published
2022

5. Possible role of low dose dexamethasone administration in listeria monocytogenes meningoencephalitis: A case series

Author

Vittoria Moscatt, Andrea Marino, Manuela Ceccarelli, Federica Cosentino, Aldo Zagami, Benedetto Celesia, Giuseppe Nunnari, and Bruno Cacopardo

Subjects
five cases of L. monocytogenes meningitis/meningoencephalitis affecting two previously healthy immunocompetent and three immunocompromised adult patients treated with ampicillin plus gentamicin are reported. In addition, General Neuroscience, non-sporulating, meningoencephalitis, four of them made a full recovery. Additionally, which typically affects immunocompromised patients, General Medicine, all the patients described in this report received a low dose of intravenous dexamethasone, highlighting the value of dexamethasone administration as part of the therapy, General Biochemistry, Genetics and Molecular Biology, Listeria (L.) monocytogenes is a gram-positive, facultatively anaerobic bacillus transmitted to humans through ingestion of contaminated foods. Listeriosis represents the third most common cause of death from foodborne illness, a literature search was performed to better explain the appropriate clinical and therapeutic management approaches for these patients, and sepsis are the most challenging to deal with. Here, and neonates. It causes several clinical syndromes, General Pharmacology, Toxicology and Pharmaceutics, the elderly, especially for patients affected by an invasive disease, of which meningitis, Listeria (L.) monocytogenes is a gram-positive, non-sporulating, facultatively anaerobic bacillus transmitted to humans through ingestion of contaminated foods. Listeriosis represents the third most common cause of death from foodborne illness, with a mortality rate of 20-30%, especially for patients affected by an invasive disease, which typically affects immunocompromised patients, pregnant women, the elderly, and neonates. It causes several clinical syndromes, of which meningitis, meningoencephalitis, and sepsis are the most challenging to deal with. Here, five cases of L. monocytogenes meningitis/meningoencephalitis affecting two previously healthy immunocompetent and three immunocompromised adult patients treated with ampicillin plus gentamicin are reported. In addition, all the patients described in this report received a low dose of intravenous dexamethasone, four of them made a full recovery. Additionally, a literature search was performed to better explain the appropriate clinical and therapeutic management approaches for these patients, highlighting the value of dexamethasone administration as part of the therapy, pregnant women, with a mortality rate of 20-30%
Published
2022

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