31 results on '"Alagna, Laura"'
Search Results
2. Incidence, microbiological and immunological characteristics of ventilator-associated pneumonia assessed by bronchoalveolar lavage and endotracheal aspirate in a prospective cohort of COVID-19 patients: CoV-AP study
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Mangioni, Davide, Panigada, Mauro, Palomba, Emanuele, Bobbio, Chiara, Chatenoud, Liliane, Alagna, Laura, Fumagalli, Jacopo, Gori, Andrea, Grancini, Anna, Guzzardella, Amedeo, Lombardi, Andrea, Matinato, Caterina, Meli, Andrea, Muscatello, Antonio, Porretti, Laura, Tomasello, Mara, Trombetta, Elena, Valenti, Luca, Bandera, Alessandra, and Grasselli, Giacomo
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- 2023
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3. Changes in upper airways microbiota in ventilator-associated pneumonia
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Alagna, Laura, Mancabelli, Leonardo, Magni, Federico, Chatenoud, Liliane, Bassi, Gabriele, Del Bianco, Silvia, Fumagalli, Roberto, Turroni, Francesca, Mangioni, Davide, Migliorino, Guglielmo M., Milani, Christian, Muscatello, Antonio, Nattino, Giovanni, Picetti, Edoardo, Pinciroli, Riccardo, Rossi, Sandra, Tonetti, Tommaso, Vargiolu, Alessia, Bandera, Alessandra, Ventura, Marco, Citerio, Giuseppe, and Gori, Andrea
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- 2023
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4. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy
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Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori., Andrea, Bandera, Alessandra, Muscatello, Antonio, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi., Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Renisi, Giulia, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Viero, Giulia, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Peyvandi, Flora, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero., Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili., Alessandro, Tettamanti, Mauro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, Leone, Sara, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Azzarà, Cecilia, Mantero, Marco, Bassetti, Matteo, Marchetti, Giulia, Nobili, Alessandro, and Gori, Andrea
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- 2024
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5. The role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic
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Marta Canuti, Maria Cristina Monti, Chiara Bobbio, Antonio Muscatello, Toussaint Muheberimana, Sante Leandro Baldi, Francesco Blasi, Ciro Canetta, Giorgio Costantino, Alessandro Nobili, Flora Peyvandi, Mauro Tettamanti, Simone Villa, Stefano Aliberti, Mario C. Raviglione, Andrea Gori, Alessandra Bandera, COVID-19 Network Study Group, Bosari Silvano, Scudeller Luigia, Fusetti Giuliana, Rusconi Laura, Dell’Orto Silvia, Prati Daniele, Valenti Luca, Giovannelli Silvia, Manunta Maria, Lamorte Giuseppe, Ferarri Francesca, Mangioni Davide, Alagna Laura, Bozzi Giorgio, Lombardi Andrea, Ungaro Riccardo, Ancona Giuseppe, Zuglian Gianluca, Bolis Matteo, Iannotti Nathalie, Ludovisi Serena, Comelli Agnese, Renisi Giulia, Biscarini Simona, Castelli Valeria, Palomba Emanuele, Fava Marco, Fortina Valeria, Liparoti Arianna, Pastena Andrea, Alberto Peri Carlo, Saltini Paola, Viero Giulia, Itri Teresa, Ferroni Valentina, Pastore Valeria, Massafra Roberta, Curri Maria Teresa, Rizzo Alice, Scarpa Stefano, Giommi Alessandro, Bianco Rosaria, Chitani Grazia Eliana, Gualtierotti Roberta, Ferrari Barbara, Rossio Raffaella, Boasi Nadia, Pagliaro Erica, Massimo Costanza, Caro Michele De, Giachi Andrea, Montano Nicola, Vigone Barbara, Bellocchi Chiara, Carandina Angelica, Fiorelli Elisa, Melli Valerie, Tobaldini Eleonora, Spotti Maura, Terranova Leonardo, Misuraca Sofia, D’Adda Alice, Fiore Silvia Della, Pasquale Marta Di, Mantero Marco, Contarini Martina, Ori Margherita, Morlacchi Letizia, Rossetti Valeria, Gramegna Andrea, Pappalettera Maria, Cavallini Mirta, Buscemi Agata, Vicenzi Marco, Rota Irena, Solbiati Monica, Furlan Ludovico, Mancarella Marta, Colombo Giulia, Colombo Giorgio, Fanin Alice, Passarella Mariele, Monzani Valter, Rovellini Angelo, Barbetta Laura, Billi Filippo, Folli Christian, Accordino Silvia, Maira Diletta, Hu Cinzia Maria, Motta Irene, Scaramellini Natalia, Fracanzani Anna Ludovica, Lombardi Rosa, Cespiati Annalisa, Cesari Matteo, Lucchi Tiziano, Proietti Marco, Calcaterra Laura, Mandelli Clara, Coppola Carlotta, Cerizza Arturo, Grasselli Giacomo, Galazzi Alessandro, Monti Igor, and Galbusera Alessia Antonella
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SARS-CoV-2 ,COVID-19 ,disease outcome ,hospitalization ,COVID-19 vaccination ,immune suppression ,Medicine (General) ,R5-920 - Abstract
Specific immune suppression types have been associated with a greater risk of severe COVID-19 disease and death. We analyzed data from patients >17 years that were hospitalized for COVID-19 at the “Fondazione IRCCS Ca′ Granda Ospedale Maggiore Policlinico” in Milan (Lombardy, Northern Italy). The study included 1727 SARS-CoV-2-positive patients (1,131 males, median age of 65 years) hospitalized between February 2020 and November 2022. Of these, 321 (18.6%, CI: 16.8–20.4%) had at least one condition defining immune suppression. Immune suppressed subjects were more likely to have other co-morbidities (80.4% vs. 69.8%, p
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- 2023
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6. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy
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Lombardi, Andrea, primary, Villa, Simone, additional, Colaneri, Marta, additional, Scaglione, Giovanni, additional, Bai, Francesca, additional, Varisco, Benedetta, additional, Bono, Valeria, additional, Vena, Antonio, additional, Dentone, Chiara, additional, Russo, Chiara, additional, Tettamanti, Mauro, additional, Renisi, Giulia, additional, Viero, Giulia, additional, Azzarà, Cecilia, additional, Mantero, Marco, additional, Peyvandi, Flora, additional, Bassetti, Matteo, additional, Marchetti, Giulia, additional, Muscatello, Antonio, additional, Nobili, Alessandro, additional, Gori, Andrea, additional, Bandera, Alessandra, additional, Bosari, Silvano, additional, Scudeller, Luigia, additional, Fusetti, Giuliana, additional, Rusconi, Laura, additional, Dell’Orto, Silvia, additional, Prati, Daniele, additional, Valenti, Luca, additional, Giovannelli, Silvia, additional, Manunta, Maria, additional, Lamorte, Giuseppe, additional, Ferarri, Francesca, additional, Gori., Andrea, additional, Mangioni, Davide, additional, Alagna, Laura, additional, Bozzi, Giorgio, additional, Lombardi., Andrea, additional, Ungaro, Riccardo, additional, Ancona, Giuseppe, additional, Mussa, Marco, additional, Mariani, Bianca Veronica, additional, Bolis, Matteo, additional, Iannotti, Nathalie, additional, Ludovisi, Serena, additional, Comelli, Agnese, additional, Biscarini, Simona, additional, Castelli, Valeria, additional, Palomba, Emanuele, additional, Fava, Marco, additional, Peri, Carlo Alberto, additional, Saltini, Paola, additional, Itri, Teresa, additional, Ferroni, Valentina, additional, Pastore, Valeria, additional, Massafra, Roberta, additional, Liparoti, Arianna, additional, Muheberimana, Toussaint, additional, Giommi, Alessandro, additional, Bianco, Rosaria, additional, Chitani, Grazia Eliana, additional, Bobbio, Chiara, additional, De Matteis, Irene, additional, Bonomi, Angelo Bianchi, additional, Gualtierotti, Roberta, additional, Ferrari, Barbara, additional, Rossio, Raffaella, additional, Boasi, Nadia, additional, Pagliaro, Erica, additional, Massimo, Costanza, additional, De Caro, Michele, additional, Giachi, Andrea, additional, Montano, Nicola, additional, Vigone, Barbara, additional, Bellocchi, Chiara, additional, Carandina, Angelica, additional, Fiorelli, Elisa, additional, Melli, Valerie, additional, Tobaldini, Eleonora, additional, Blasi, Francesco, additional, Aliberti, Stefano, additional, Spotti, Maura, additional, Terranova, Leonardo, additional, Misuraca, Sofia, additional, D’Adda, Alice, additional, Della Fiore, Silvia, additional, Di Pasquale, Marta, additional, Mantero., Marco, additional, Contarini, Martina, additional, Ori, Margherita, additional, Morlacchi, Letizia, additional, Rossetti, Valeria, additional, Gramegna, Andrea, additional, Pappalettera, Maria, additional, Cavallini, Mirta, additional, Buscemi, Agata, additional, Vicenzi, Marco, additional, Rota, Irena, additional, Costantino, Giorgio, additional, Solbiati, Monica, additional, Furlan, Ludovico, additional, Mancarella, Marta, additional, Colombo, Giulia, additional, Colombo, Giorgio, additional, Fanin, Alice, additional, Passarella, Mariele, additional, Monzani, Valter, additional, Canetta, Ciro, additional, Rovellini, Angelo, additional, Barbetta, Laura, additional, Billi, Filippo, additional, Folli, Christian, additional, Accordino, Silvia, additional, Maira, Diletta, additional, Hu, Cinzia Maria, additional, Motta, Irene, additional, Scaramellini, Natalia, additional, Fracanzani, Anna Ludovica, additional, Lombardi, Rosa, additional, Cespiati, Annalisa, additional, Cesari, Matteo, additional, Lucchi, Tiziano, additional, Proietti, Marco, additional, Calcaterra, Laura, additional, Mandelli, Clara, additional, Coppola, Carlotta, additional, Cerizza, Arturo, additional, Pesenti, Antonio Maria, additional, Grasselli, Giacomo, additional, Galazzi, Alessandro, additional, Nobili., Alessandro, additional, Monti, Igor, additional, Galbussera, Alessia Antonella, additional, Crisafulli, Ernesto, additional, Girelli, Domenico, additional, Maroccia, Alessio, additional, Gabbiani, Daniele, additional, Busti, Fabiana, additional, Vianello, Alice, additional, Biondan, Marta, additional, Sartori, Filippo, additional, Faverio, Paola, additional, Pesci, Alberto, additional, Zucchetti, Stefano, additional, Bonfanti, Paolo, additional, Rossi, Marianna, additional, Beretta, Ilaria, additional, Spolti, Anna, additional, Harari, Sergio, additional, Elia, Davide, additional, Cassandro, Roberto, additional, Caminati, Antonella, additional, Cipollone, Francesco, additional, Guagnano, Maria Teresa, additional, D’Ardes, Damiano, additional, Rossi, Ilaria, additional, Vezzani, Francesca, additional, Spanevello, Antonio, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Contoli, Marco, additional, Papi, Alberto, additional, Morandi, Luca, additional, Battistini, Nicholas, additional, Moreo, Guido Luigi, additional, Iannuzzi, Pasqualina, additional, Fumagalla, Daniele, additional, and Leone, Sara, additional
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- 2024
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7. New Antibiotics Against Multidrug-Resistant Gram-Negative Bacteria in Liver Transplantation: Clinical Perspectives, Toxicity, and PK/PD Properties
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Lombardi, Andrea, primary, Alagna, Laura, additional, Palomba, Emanuele, additional, Viero, Giulia, additional, Tonizzo, Anna, additional, Mangioni, Davide, additional, and Bandera, Alessandra, additional
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- 2024
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8. Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis
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Kyriazopoulou, Evdoxia, Huet, Thomas, Cavalli, Giulio, Gori, Andrea, Kyprianou, Miltiades, Pickkers, Peter, Eugen-Olsen, Jesper, Clerici, Mario, Veas, Francisco, Chatellier, Gilles, Kaplanski, Gilles, Netea, Mihai G., Pontali, Emanuele, Gattorno, Marco, Cauchois, Raphael, Kooistra, Emma, Kox, Matthijs, Bandera, Alessandra, Beaussier, Hélène, Mangioni, Davide, Dagna, Lorenzo, van der Meer, Jos W.M., Giamarellos-Bourboulis, Evangelos J., Hayem, Gilles, Volpi, Stefano, Sormani, Maria Pia, Signori, Alessio, Bozzi, Giorgio, Minoia, Francesca, Aliberti, Stefano, Grasselli, Giacomo, Alagna, Laura, Lombardi, Andrea, Ungaro, Riccardo, Agostoni, Carlo, Blasi, Francesco, Costantino, Giorgio, Fracanzani, Anna Ludovica, Montano, Nicola, Peyvandi, Flora, Sottocorno, Marcello, Muscatello, Antonio, Filocamo, Giovanni, Papadopoulos, Antonios, Mouktaroudi, Maria, Karakike, Eleni, Saridaki, Maria, Gkavogianni, Theologia, Katrini, Konstantina, Vechlidis, Nikolaos, Avgoustou, Christina, Chalvatzis, Stamatios, Marantos, Theodoros, Damoulari, Christina, Damoraki, Georgia, Ktena, Sofia, Tsilika, Maria, Koufargyris, Panagiotis, Karageorgos, Athanasios, Droggiti, Dionysia-Irene, Koliakou, Aikaterini, Poulakou, Garyfallia, Tsiakos, Konstantinos, Myrodia, Dimitra-Melia, Gravvani, Areti, Trontzas, Ioannis P., Syrigos, Konstantinos, Kalomenidis, Ioannis, Kranidioti, Eleftheria, Panagopoulos, Periklis, Petrakis, Vasileios, Metallidis, Simeon, Loli, Georgia, Tsachouridou, Olga, Dalekos, George N., Gatselis, Nikolaos, Stefos, Aggelos, Georgiadou, Sarah, Lygoura, Vassiliki, Milionis, Haralampos, Kosmidou, Maria, Papanikolaou, Ilias C., Akinosoglou, Karolina, Giannitsioti, Efthymia, Chrysos, Georgios, Mavroudis, Panagiotis, Sidiropoulou, Chrysanthi, Adamis, Georgios, Fragkou, Archontoula, Rapti, Aggeliki, Alexiou, Zoi, Symbardi, Styliani, Masgala, Aikaterini, Kostaki, Konstantina, Kostis, Evangelos, Samarkos, Michael, Bakakos, Petros, Tzavara, Vassiliki, Dimakou, Katerina, Tzatzagou, Glykeria, Chini, Maria, Kotsis, Vasileios, Tsoukalas, George, Bliziotis, Ioannis, Doumas, Michael, Argyraki, Aikaterini, Kainis, Ilias, Fantoni, Massimo, Cingolani, Antonella, Angheben, Andrea, Cardellino, Chiara Simona, Castelli, Francesco, Serino, Francesco Saverio, Nicastri, Emanuele, Ippolito, Giuseppe, Bassetti, Matteo, Selmi, Carlo, Netea, Mihai G, van der Meer, Jos W M, and Giamarellos-Bourboulis, Evangelos J
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- 2021
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9. Adverse events during intravenous fosfomycin therapy in a real-life scenario. Risk factors and the potential role of therapeutic drug monitoring.
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Biscarini, Simona, Mangioni, Davide, Bobbio, Chiara, Mela, Ludovica, Alagna, Laura, Baldelli, Sara, Blasi, Francesco, Canetta, Ciro, Ceriotti, Ferruccio, Gori, Andrea, Grasselli, Giacomo, Mariani, Bianca, Muscatello, Antonio, Cattaneo, Dario, and Bandera, Alessandra
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DRUG monitoring ,LIQUID chromatography-mass spectrometry ,INTRAVENOUS therapy ,HYPERNATREMIA ,SEPTIC shock ,RESPIRATORY infections - Abstract
Background: Intravenous fosfomycin (IVFOF) is gaining interest in severe infections. Its use may be limited by adverse events (AEs). Little experience exists on IVFOF therapeutic drug monitoring (TDM) in real-life setting. Patients and methods: Retrospective study of patients receiving IVFOF for > 48 h at Policlinico Hospital (Milan, Italy) from 01/01/2019 to 01/01/2023. AEs associated to IVFOF graded CTCAE ≥ II were considered. Demographic and clinical risk factors for IVFOF-related AEs were analysed with simple and multivariable regression models. The determination of IVFOF TDM was made by a rapid ultraperformance liquid chromatography mass spectrometry method (LC-MS/MS) on plasma samples. The performance of TDM (trough levels (Cmin) in intermittent infusion, steady state levels (Css) in continuous infusion) in predicting AEs ≤ 5 days after its assessment was evaluated. Results: Two hundred and twenty-four patients were included. At IVFOF initiation, 81/224 (36.2%) patients were in ICU and 35/224 (15.7%) had septic shock. The most frequent infection site was the low respiratory tract (124/224, 55.4%). Ninety-five patients (42.4%) experienced ≥ 1AEs, with median time of 4.0 (2.0–7.0) days from IVFOF initiation. Hypernatremia was the most frequent AE (53/224, 23.7%). Therapy discontinuation due to AEs occurred in 38/224 (17.0%). ICU setting, low respiratory tract infections and septic shock resulted associated with AEs (RR
adjusted 1.59 (95%CI:1.09–2.31), 1.46 (95%CI:1.03–2.07) and 1.73 (95%CI:1.27–2.37), respectively), while IVFOF daily dose did not. Of the 68 patients undergone IVFOF TDM, TDM values predicted overall AEs and hypernatremia with AUROC of 0.65 (95%CI:0.44–0.86) and 0.91 (95%CI:0.79-1.0) respectively for Cmin, 0.67 (95%CI:0.39–0.95) and 0.76 (95%CI:0.52-1.0) respectively for Css. Conclusions: We provided real world data on the use of IVFOF-based regimens and associated AEs. IVFOF TDM deserves further research as it may represent a valid tool to predict AEs. Key points: Real world data on intravenous fosfomycin for severe bacterial infections. AEs occurred in over 40% (therapy discontinuation in 17%) and were related to baseline clinical severity but not to fosfomycin dose. TDM showed promising results in predicting AEs. [ABSTRACT FROM AUTHOR]- Published
- 2024
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10. Higher levels of IgA and IgG at sepsis onset are associated with higher mortality: results from the Albumin Italian Outcome Sepsis (ALBIOS) trial
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Alagna, Laura, Meessen, Jennifer M. T. A., Bellani, Giacomo, Albiero, Daniela, Caironi, Pietro, Principale, Irene, Vivona, Luigi, Grasselli, Giacomo, Motta, Francesca, Agnelli, Nicolò M., Parrini, Vieri, Romagnoli, Stefano, Keim, Roberto, Di Marzo Capozzi, Francesca, Taccone, Fabio S., Taccone, Walter, Bottazzi, Barbara, Bandera, Alessandra, Cortegiani, Andrea, and Latini, Roberto
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- 2021
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11. Perfusion fluid‐related infections in liver transplant recipients: A 5‐year, single‐center, retrospective study
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Lombardi, Andrea, primary, Renisi, Giulia, additional, Dondossola, Daniele, additional, Palomba, Emanuele, additional, Del Prete, Luca, additional, Viero, Giulia, additional, Zefelippo, Arianna, additional, Azzarà, Cecilia, additional, Maccaro, Angelo, additional, Perali, Carolina, additional, Alagna, Laura, additional, Franchi, Eloisa, additional, Muscatello, Antonio, additional, Gori, Andrea, additional, Grasselli, Giacomo, additional, Donato, Maria Francesca, additional, Matinato, Caterina, additional, Caccamo, Lucio, additional, Antonelli, Barbara, additional, and Bandera, Alessandra, additional
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- 2023
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12. Surgical site infections in liver transplantation in the era of multidrug-resistant bacteria
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BRIGATI, Emilietta, primary, BANDERA, Alessandra, additional, CONSONNI, Dario, additional, GRANCINI, Anna, additional, MAGGI, Umberto, additional, PICONI, Stefania, additional, ALAGNA, Laura, additional, PALOMBA, Emanuele, additional, and CACCAMO, Lucio, additional
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- 2023
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13. Gut and airway microbiota dysbiosis and their role in COVID-19 and long-COVID
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Ancona, Giuseppe, primary, Alagna, Laura, additional, Alteri, Claudia, additional, Palomba, Emanuele, additional, Tonizzo, Anna, additional, Pastena, Andrea, additional, Muscatello, Antonio, additional, Gori, Andrea, additional, and Bandera, Alessandra, additional
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- 2023
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14. Validation of the INCREMENT‐SOT‐CPE score in a large cohort of liver transplant recipients with carbapenem‐resistant Enterobacterales infection
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Rinaldi, Matteo, Bonazzetti, Cecilia, Gallo, Mena, Ferraro, Giuseppe, Freire, Maristela, Terrabuio, Débora Raquel Benedita, Tandoi, Francesco, Romagnoli, Renato, De Rosa, Francesco Giuseppe, Mularoni, Alessandra, Ferrarese, Alberto, Burra, Patrizia, Halpern, Marcia, Balbi, Elizabeth, Simkins, Jacques, Abbo, Lilian, Morrás, Ignacio, Cantero, Mireia, Alagna, Laura, Bandera, Alessandra, Clemente, Wanessa Trinidade, Valerio, Maricela, Fernández, Ainhoa, Muñoz, Patricia, Statlender, Liran, Yahav, Dafna, Camargo, Luis Fernando Aranha, Girão, Evelyne Santana, Grossi, Paolo, Viale, Pierluigi, Curti, Stefania, Giannella, Maddalena, Rinaldi M., Bonazzetti C., Gallo M., Ferraro G., Freire M., Terrabuio D.R.B., Tandoi F., Romagnoli R., De Rosa F.G., Mularoni A., Ferrarese A., Burra P., Halpern M., Balbi E., Simkins J., Abbo L., Morrás I., Cantero M., Alagna L., Bandera A., Clemente W.T., Valerio M., Fernández A., Muñoz P., Statlender L., Yahav D., Camargo L.F.A., Girão E.S., Grossi P., Viale P., Curti S., and Giannella M.
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INCREMENT-SOT-CPE score ,Transplantation ,Infectious Diseases ,CRE infection ,liver transplantation ,SOT - Abstract
Background: Management of infections due to carbapenemase-resistant Enterobacterales (CRE) in solid organ transplant (SOT) recipients remains a difficult challenge. The INCREMENT-SOT-CPE score has been specifically developed from SOT recipients to stratify mortality risk, but an external validation is lacking.Methods: Multicenter retrospective cohort study of liver transplant (LT) recipients colonized with CRE infection who developed infection after transplant over 7-year period. Primary endpoint was all-cause 30-day mortality from infection onset. A comparison between INCREMENT-SOT-CPE and other selected scores was performed. A two-level mixed effects logistic regression model with random effects for the center was fitted. Performance characteristics at optimal cut-point were calculated. Multivariable Cox regression analysis of risk factors for all-cause 30-day mortality was carried out.Results: Overall, 250 CRE carriers developed infection after LT and were analyzed. The median age was 55 years (interquartile range [IQR]: 46-62) and 157 were males (62.8%). All-cause 30-day mortality was 35.6%. A sequential organ failure assessment (SOFA) score >= 11 showed a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of 69.7%, 76.4%, 62.0%, 82.0%, and 74.0%, respectively. An INCREMENT-SOT-CPE >= 11 reported a sensitivity, specificity, PPV, NPV, and accuracy of 73.0%, 62.1%, 51.6%, 80.6% and 66.0%, respectively. At multivariable analysis acute renal failure, prolonged mechanical ventilation, INCREMENT-SOT-CPE score >= 11 and SOFA score >= 11 were independently associated with all-cause 30-day mortality, while a tigecycline-based targeted regimen was found to be protective.Conclusions: Both INCREMENT-SOT-CPE >= 11 and SOFA >= 11 were identified as strong predictors of all-cause 30-day mortality in a large cohort of CRE carriers developing infection after LT.
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- 2023
15. 310. Data Curation
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Alagna, Laura
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ipres2018 ,digital preservation ,preservation ,conference proceedings ,310. Data Curation - Abstract
The four papers in Session 310 explore the issues and topics pertaining to the theme of Data Curation with exampes of current practice. Session chair: Laura Alagna.
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- 2022
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16. Beyond the Repository Curatorial Toolkit
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Alagna, Laura and Work, Lauren
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digital preservation ,digital collections ,distributed digital preservation ,curation - Abstract
This toolkit is intended to assist cultural heritage organizations in choosing materials to send to distributed digital preservation (DDP) systems, networks in geographically-dispersed locations designed to perform preservation actions.
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- 2022
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17. Prognostic Value of Mid-Region Proadrenomedullin and In Vitro Interferon Gamma Production for In-Hospital Mortality in Patients with COVID-19 Pneumonia and Respiratory Failure: An Observational Prospective Study
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Mangioni, Davide, primary, Oggioni, Massimo, additional, Chatenoud, Liliane, additional, Liparoti, Arianna, additional, Uceda Renteria, Sara, additional, Alagna, Laura, additional, Biscarini, Simona, additional, Bolis, Matteo, additional, Di Modugno, Adriana, additional, Mussa, Marco, additional, Renisi, Giulia, additional, Ungaro, Riccardo, additional, Muscatello, Antonio, additional, Gori, Andrea, additional, Ceriotti, Ferruccio, additional, and Bandera, Alessandra, additional
- Published
- 2022
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18. Effectiveness of a Multifaced Antibiotic Stewardship Program: A Pre-Post Study in Seven Italian ICUs
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Mandelli, Giulia, primary, Dore, Francesca, additional, Langer, Martin, additional, Garbero, Elena, additional, Alagna, Laura, additional, Bianchin, Andrea, additional, Ciceri, Rita, additional, Di Paolo, Antonello, additional, Giani, Tommaso, additional, Giugni, Aimone, additional, Gori, Andrea, additional, Lefons, Ugo, additional, Muscatello, Antonio, additional, Olivieri, Carlo, additional, Pan, Angelo, additional, Pedeferri, Matteo, additional, Rossi, Marianna, additional, Rossolini, Gian Maria, additional, Russo, Emanuele, additional, Silengo, Daniela, additional, Viaggi, Bruno, additional, Bertolini, Guido, additional, and Finazzi, Stefano, additional
- Published
- 2022
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19. How Vaccinations Changed the Outcome of COVID-19 Infections in Kidney Transplant Patients: Single-Center Experience
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Campise, Mariarosaria, primary, Alfieri, Carlo Maria, additional, Benedetti, Matteo, additional, Perna, Alessandro, additional, Miglio, Roberta, additional, Molinari, Paolo, additional, Cervesato, Angela, additional, Giuliani, Silvia, additional, Gandolfo, Maria Teresa, additional, Regalia, Anna, additional, Cresseri, Donata, additional, Alagna, Laura, additional, Gori, Andrea, additional, and Castellano, Giuseppe, additional
- Published
- 2022
- Full Text
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20. Nocardia Infections in the Immunocompromised Host: A Case Series and Literature Review
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Palomba, Emanuele, primary, Liparoti, Arianna, additional, Tonizzo, Anna, additional, Castelli, Valeria, additional, Alagna, Laura, additional, Bozzi, Giorgio, additional, Ungaro, Riccardo, additional, Muscatello, Antonio, additional, Gori, Andrea, additional, and Bandera, Alessandra, additional
- Published
- 2022
- Full Text
- View/download PDF
21. A highly virulent variant of HIV-1 circulating in the Netherlands
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Wymant, Chris, Bezemer, Daniela, Blanquart, François, Ferretti, Luca, Gall, Astrid, Hall, Matthew, Golubchik, Tanya, Bakker, Margreet, Ong, Swee Hoe, Zhao, Lele, Bonsall, David, de Cesare, Mariateresa, MacIntyre-Cockett, George, Abeler-Dörner, Lucie, Albert, Jan, Bannert, Norbert, Fellay, Jacques, Grabowski, M Kate, Gunsenheimer-Bartmeyer, Barbara, Günthard, Huldrych F, Kivelä, Pia, Kouyos, Roger D, Laeyendecker, Oliver, Meyer, Laurence, Porter, Kholoud, Ristola, Matti, van Sighem, Ard, Berkhout, Ben, Kellam, Paul, Cornelissen, Marion, Reiss, Peter, Fraser, Christophe, Aubert, V, Battegay, M, Bernasconi, E, Böni, J, Braun, D L, Bucher, H C, Burton-Jeangros, C, Calmy, A, Cavassini, M, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Furrer, H, Fux, C A, Gorgievski, M, Günthard, H, Haerry, D, Hasse, B, Hirsch, H H, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Ledergerber, B, Martinetti, G, de Tejada, B Martinez, Marzolini, C, Metzner, K, Müller, N, Nadal, D, Nicca, D, Pantaleo, G, Rauch, A, Regenass, S, Rudin, C, Schöni-Affolter, F, Schmid, P, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Weber, R, Yerly, S, van der Valk, M, Geerlings, S E, Goorhuis, A, Hovius, J W, Lempkes, B, Nellen, F J B, van der Poll, T, Prins, J M, Reiss, P, van Vugt, M, Wiersinga, W J, Wit, F W M N, van Duinen, M, van Eden, J, Hazenberg, A, van Hes, A M H, Pijnappel, F J J, Smalhout, S Y, Weijsenfeld, A M, Jurriaans, S, Back, N K T, Zaaijer, H L, Berkhout, B, Cornelissen, M T E, Schinkel, C J, Wolthers, K C, Peters, E J G, van Agtmael, M A, Autar, R S, Bomers, M, Sigaloff, K C E, Heitmuller, M, Laan, L M, Ang, C W, van Houdt, R, Jonges, M, Kuijpers, T W, Pajkrt, D, Scherpbier, H J, de Boer, C, van der Plas, A, van den Berge, M, Stegeman, A, Baas, S, Hage de Looff, L, Buiting, A, Reuwer, A, Veenemans, J, Wintermans, B, Pronk, M J H, Ammerlaan, H S M, van den Bersselaar, D N J, de Munnik, E S, Deiman, B, Jansz, A R, Scharnhorst, V, Tjhie, J, Wegdam, M C A, van Eeden, A, Nellen, J, Brokking, W, Elsenburg, L J M, Nobel, H, van Kasteren, M E E, Berrevoets, M A H, Brouwer, A E, Adams, A, van Erve, R, de Kruijf-van de Wiel, B A F M, Keelan-Phaf, S, van der Ven, B, Buiting, A G M, Murck, J L, de Vries-Sluijs, T E M S, Bax, H I, van Gorp, E C M, de Jong-Peltenburg, N C, de Mendonç A Melo, M, van Nood, E, Nouwen, J L, Rijnders, B J A, Rokx, C, Schurink, C A M, Slobbe, L, Verbon, A, Bassant, N, van Beek, J E A, Vriesde, M, van Zonneveld, L M, de Groot, J, Boucher, C A B, Koopmans, M P G, van Kampen, J J A, Fraaij, P L A, van Rossum, A M C, Vermont, C L, van der Knaap, L C, Visser, E, Branger, J, Douma, R A, Cents-Bosma, A S, Duijf-van de Ven, C J H M, Schippers, E F, van Nieuwkoop, C, van Ijperen, J M, Geilings, J, van der Hut, G, van Burgel, N D, Leyten, E M S, Gelinck, L B S, Mollema, F, Davids-Veldhuis, S, Tearno, C, Wildenbeest, G S, Heikens, E, Groeneveld, P H P, Bouwhuis, J W, Lammers, A J J, Kraan, S, van Hulzen, A G W, Kruiper, M S M, van der Bliek, G L, Bor, P C J, Debast, S B, Wagenvoort, G H J, Kroon, F P, de Boer, M G J, Jolink, H, Lambregts, M M C, Roukens, A H E, Scheper, H, Dorama, W, van Holten, N, Claas, E C J, Wessels, E, den Hollander, J G, El Moussaoui, R, Pogany, K, Smit, J V, Struik-Kalkman, D, van Niekerk, T, Pontesilli, O, Lowe, S H, Oude Lashof, A M L, Posthouwer, D, van Wolfswinkel, M E, Ackens, R P, Burgers, K, Schippers, J, Weijenberg-Maes, B, van Loo, I H M, Havenith, T R A, van Vonderen, M G A, Kampschreur, L M, Faber, S, Steeman-Bouma, R, Al Moujahid, A, Kootstra, G J, Delsing, C E, van der Burg-van de Plas, M, Scheiberlich, L, Kortmann, W, van Twillert, G, Renckens, R, Ruiter-Pronk, D, van Truijen-Oud, F A, Cohen Stuart, J W T, Jansen, E R, Hoogewerf, M, Rozemeijer, W, van der Reijden, W A, Sinnige, J C, Brinkman, K, van den Berk, G E L, Blok, W L, Lettinga, K D, de Regt, M, Schouten, W E M, Stalenhoef, J E, Veenstra, J, Vrouenraets, S M E, Blaauw, H, Geerders, G F, Kleene, M J, Kok, M, Knapen, M, van der Meché, I B, Mulder-Seeleman, E, Toonen, A J M, Wijnands, S, Wttewaal, E, Kwa, D, van Crevel, R, van Aerde, K, Dofferhoff, A S M, Henriet, S S V, Ter Hofstede, H J M, Hoogerwerf, J, Keuter, M, Richel, O, Albers, M, Grintjes-Huisman, K J T, de Haan, M, Marneef, M, Strik-Albers, R, Rahamat-Langendoen, J, Stelma, F F, Burger, D, Gisolf, E H, Hassing, R J, Claassen, M, Ter Beest, G, van Bentum, P H M, Langebeek, N, Tiemessen, R, Swanink, C M A, van Lelyveld, S F L, Soetekouw, R, van der Prijt, L M M, van der Swaluw, J, Bermon, N, Jansen, R, Herpers, B L, Veenendaal, D, Verhagen, D W M, Lauw, F N, van Broekhuizen, M C, van Wijk, M, Bierman, W F W, Bakker, M, Kleinnijenhuis, J, Kloeze, E, Middel, A, Postma, D F, Schölvinck, E H, Stienstra, Y, Verhage, A R, Wouthuyzen-Bakker, M, Boonstra, A, de Groot-de Jonge, H, van der Meulen, P A, de Weerd, D A, Niesters, H G M, van Leer-Buter, C C, Knoester, M, Hoepelman, A I M, Arends, J E, Barth, R E, Bruns, A H W, Ellerbroek, P M, Mudrikova, T, Oosterheert, J J, Schadd, E M, van Welzen, B J, Aarsman, K, Griffioen-van Santen, B M G, de Kroon, I, van Berkel, M, van Rooijen, C S A M, Schuurman, R, Verduyn-Lunel, F, Wensing, A M J, Bont, L J, Geelen, S P M, Loeffen, Y G T, Wolfs, T F W, Nauta, N, Rooijakkers, E O W, Holtsema, H, Voigt, R, van de Wetering, D, Alberto, A, van der Meer, I, Rosingh, A, Halaby, T, Zaheri, S, Boyd, A C, Bezemer, D O, van Sighem, A I, Smit, C, Hillebregt, M, de Jong, A, Woudstra, T, Bergsma, D, Meijering, R, van de Sande, L, Rutkens, T, van der Vliet, S, de Groot, L, van den Akker, M, Bakker, Y, El Berkaoui, A, Bezemer, M, Brétin, N, Djoechro, E, Groters, M, Kruijne, E, Lelivelt, K J, Lodewijk, C, Lucas, E, Munjishvili, L, Paling, F, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, Schoorl, M, Schnörr, P, Scheigrond, A, Tuijn, E, Veenenberg, L, Visser, K M, Witte, E C, Van Frankenhuijsen, Maartje, Allegre, Thierry, Makhloufi, Djamila, Livrozet, Jean-Michel, Chiarello, Pierre, Godinot, Mathieu, Brunel-Dalmas, Florence, Gibert, Sylvie, Trepo, Christian, Peyramond, Dominique, Miailhes, Patrick, Koffi, Joseph, Thoirain, Valérie, Brochier, Corinne, Baudry, Thomas, Pailhes, Sylvie, Lafeuillade, Alain, Philip, Gisèle, Hittinger, Gilles, Assi, Assi, Lambry, Véronique, Rosenthal, Eric, Naqvi, Alissa, Dunais, Brigitte, Cua, Eric, Pradier, Christian, Durant, Jacques, Joulie, Aline, Quinsat, Denis, Tempesta, Serge, Ravaux, Isabelle, Martin, Isabelle Poizot, Faucher, Olivia, Cloarec, Nicolas, Champagne, Hélène, Pichancourt, Gilles, Morlat, Philippe, Pistone, Thierry, Bonnet, Fabrice, Mercie, Patrick, Faure, Isabelle, Hessamfar, Mojgan, Malvy, Denis, Lacoste, Denis, Pertusa, Marie-Carmen, Vandenhende, Marie-Anne, Bernard, Noëlle, Paccalin, François, Martell, Cédric, Roger-Schmelz, Julien, Receveur, Marie-Catherine, Duffau, Pierre, Dondia, Denis, Ribeiro, Emmanuel, Caltado, Sabrina, Neau, Didier, Dupont, Michel, Dutronc, Hervé, Dauchy, Frédéric, Cazanave, Charles, Vareil, Marc-Olivier, Wirth, Gaétane, Le Puil, Séverine, Pellegrin, Jean-Luc, Raymond, Isabelle, Viallard, Jean-François, Chaigne de Lalande, Severin, Garipuy, Daniel, Delobel, Pierre, Obadia, Martine, Cuzin, Lise, Alvarez, Muriel, Biezunski, Noemie, Porte, Lydie, Massip, Patrice, Debard, Alexa, Balsarin, Florence, Lagarrigue, Myriam, Prevoteau du Clary, François, Aquilina, Christian, Reynes, Jacques, Baillat, Vincent, Merle, Corinne, Lemoing, Vincent, Atoui, Nadine, Makinson, Alain, Jacquet, Jean Marc, Psomas, Christina, Tramoni, Christine, Aumaitre, Hugues, Saada, Mathieu, Medus, Marie, Malet, Martine, Eden, Aurélia, Neuville, Ségolène, Ferreyra, Milagros, Sotto, Albert, Barbuat, Claudine, Rouanet, Isabelle, Leureillard, Didier, Mauboussin, Jean-Marc, Lechiche, Catherine, Donsesco, Régine, Cabie, André, Abel, Sylvie, Pierre-Francois, Sandrine, Batala, Anne-Sophie, Cerland, Christophe, Rangom, Camille, Theresine, Nadine, Hoen, Bruno, Lamaury, Isabelle, Fabre, Isabelle, Schepers, Kinda, Curlier, Elodie, Ouissa, Rachida, Gaud, Catherine, Ricaud, Carole, Rodet, Roland, Wartel, Guillaume, Sautron, Carmele, Beck-Wirth, Geneviève, Michel, Catherine, Beck, Charles, Halna, Jean-Michel, Kowalczyk, Jakub, Benomar, Meryem, Drobacheff-Thiebaut, Christine, Chirouze, Catherine, Faucher, Jean-François, Parcelier, François, Foltzer, Adeline, Haffner-Mauvais, Cécile, Hustache Mathieu, Mathieu, Proust, Aurélie, Piroth, Lionel, Chavanet, Pascal, Duong, Michel, Buisson, Marielle, Waldner, Anne, Mahy, Sophie, Gohier, Sandrine, Croisier, Delphine, May, Thierry, Delestan, Mikael, Andre, Marie, Zadeh, Mahsa Mohseni, Martinot, Martin, Rosolen, Béatrice, Pachart, Anne, Martha, Benoît, Jeunet, Noëlle, Rey, David, Cheneau, Christine, Partisani, Maria, Priester, Michèle, Bernard-Henry, Claudine, Batard, Marie-Laure, Fischer, Patricia, Berger, Jean-Luc, Kmiec, Isabelle, Robineau, Olivier, Huleux, Thomas, Ajana, Faïza, Alcaraz, Isabelle, Allienne, Christophe, Baclet, Véronique, Meybeck, Agnès, Valette, Michel, Viget, Nathalie, Aissi, Emmanuelle, Biekre, Raphael, Cornavin, Pauline, Merrien, Dominique, Seghezzi, Jean-Christophe, Machado, Moise, Diab, Georges, Raffi, François, Bonnet, Bénédicte, Allavena, Clotilde, Grossi, Olivier, Reliquet, Véronique, Billaud, Eric, Brunet, Cecile, Bouchez, Sabelline, Morineau-Le Houssine, Pascale, Sauser, Fabienne, Boutoille, David, Besnier, Michel, Hue, Hervé, Hall, Nolwenn, Brosseau, Delphine, Souala, Faouzi, Michelet, Christian, Tattevin, Pierre, Arvieux, Cédric, Revest, Matthieu, Leroy, Helene, Chapplain, Jean-Marc, Dupont, Matthieu, Fily, Fabien, Patra-Delo, Solène, Lefeuvre, Céline, Bernard, Louis, Bastides, Frédéric, Nau, Pascale, Verdon, Renaud, de la Blanchardiere, Arnaud, Martin, Anne, Feret, Philippe, Geffray, Loïk, Daniel, Corinne, Rohan, Jennifer, Fialaire, Pascale, Chennebault, Jean Marie, Rabier, Valérie, Abgueguen, Pierre, Rehaiem, Sami, Luycx, Odile, Niault, Mathilde, Moreau, Philippe, Poinsignon, Yves, Goussef, Marie, 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Pascale, Eliazevitch, Murielle, Pierre, Isabelle, Collias, Lio, Viard, Jean-Paul, Gilquin, Jacques, Sobel, Alain, Slama, Laurence, Ghosn, Jade, Hadacek, Blanka, Thu-Huyn, Nugyen, Nait-Ighil, Lella, Cros, Agnes, Maignan, Aline, Duvivier, Claudine, Consigny, Paul Henri, Lanternier, Fanny, Shoai-Tehrani, Michka, Touam, Fatima, Jerbi, Saadia, Bodard, Loïc, Jung, Corinne, Goujard, Cécile, Quertainmont, Yann, Duracinsky, Martin, Segeral, Olivier, Blanc, Arnaud, Peretti, Delphine, Cheret, Antoine, Chantalat, Christelle, Dulucq, Marie Josée, Levy, Yves, Lelievre, Jean Daniel, Lascaux, Anne Sophie, Dumont, Cécile, Boue, François, Chambrin, Véronique, Abgrall, Sophie, Kansau, Imad, Raho-Moussa, Mariem, De Truchis, Pierre, Dinh, Aurélien, Davido, Benjamin, Marigot, Dhiba, Berthe, Huguette, Devidas, Alain, Chevojon, Pierre, Chabrol, Amélie, Agher, Nouara, Lemercier, Yvon, Chaix, Fabrice, Turpault, Isabelle, Bouchaud, Olivier, Honore, Patricia, Rouveix, Elisabeth, Reimann, Evelyne, Belan, Alix 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Lean, C, Morris, S, Winter, A, Faulkner, S, Goorney, B, Howard, L, Fairley, I, Stemp, C, Short, L, Gomez, M, Young, F, Roberts, M, Green, S, Sivakumar, K, Minton, J, Siminoni, A, Calderwood, J, Greenhough, D, DeSouza, C, Muthern, Lisa, Orkin, C, Murphy, S, Truvedi, M, McLean, K, Hawkins, D, Higgs, C, Moyes, A, Antonucci, S, McCormack, S, Lynn, W, Bevan, M, Fox, J, Teague, A, Anderson, J, Mguni, S, Post, F, Campbell, L, Mazhude, C, Russell, H, Carrick, G, Ainsworth, J, Waters, A, Byrne, P, Johnson, M, Kuldanek, K, Mullaney, S, Lawlor, V, Melville, R, Sukthankar, A, Thorpe, S, Murphy, C, Wilkins, E, Ahmad, S, Green, P, Tayal, S, Ong, E, Meaden, J, Riddell, L, Loay, D, Peacock, K, Blackman, H, Harindra, V, Saeed, A M, Allen, S, Natarajan, U, Williams, O, Lacey, H, Care, C, Bowman, C, Herman, S, Devendra, S V, Wither, J, Bridgwood, A, Singh, G, Bushby, S, Kellock, D, Young, S, Rooney, G, Snart, B, Currie, J, Fitzgerald, M, Arumainayyagam, J, Chandramani, S, Rajamanoharan, S, Robinson, T, Taylor, B, Brewer, C, Mayr, Christoph, Schmidt, Wolfgang, Speidel, Andrea, Strohbach, Frank, Arastéh, Keikawus, Cordes, Christiane, Stündel, Manfred, Claus, Jörg, Baumgarten, Axel, Carganico, Andreas, Ingiliz, Patrick, Dupke, Stephan, Freiwald, Matthias, Rausch, Michael, Moll, Arend, Schleehauf, Dorothea, Hintsche, Bettina, Klausen, Gerd, Jessen, Heiko, Jessen, Arne, Köppe, Siegfried, Kreckel, Peter, Schranz, Dietmar, Fischer, Klaus, Schulbin, Hubert, Speer, Miriam, Glaunsinger, Tobias, Wicke, Thomas, Bieniek, Bernhard, Hillenbrand, Heribert, Schlote, Frank, Lauenroth-Mai, Elke, Schuler, Christoph, Schürmann, Dirk, Wesselmann, Hans, Brockmeyer, Norbert, Gehring, Peter, Schmalöer, Dirk, Hower, Martin, Spornraft-Ragaller, Petra, Häussinger, Dieter, Reuter, Stefan, Esser, Stefan, Markus, Rudolf, Kreft, Burkhard, Berzow, Dirk, Christl, Andreas, Meyer, Andreas, Plettenberg, Andreas, Stoehr, Albrecht, Graefe, Katrin, Lorenzen, Thore, Adam, Axel, Schewe, Knut, Weitner, Lutwin, Fenske, Stefan, Hansen, Stefan, Stellbrink, Hans-Jürgen, Wiemer, Dorothea, Hertling, Sandra, Schmidt, Reinhold, Arbter, Peter, Claus, Bernd, Galle, Peter, Jäger, Hans, Jä Gel-Guedes, Eva, Postel, Nils, Fröschl, Monika, Spinner, Christoph, Bogner, Johannes, Salzberger, Bernd, Schölmerich, Jürgen, Audebert, Franz, Marquardt, Ties, Schaffert, Andreas, Schnaitmann, Eiko, Trein, Andreas, Frietsch, Bernhard, Müller, Marcus, Ulmer, Albrecht, Detering-Hübner, Barbara, Kern, Peter, Schubert, Franz, Dehn, Günther, Schreiber, Maria, Güler, Cengiz, Schmidt, Daniel, Meixenberger, Karolin, Medical Microbiology & Infectious Diseases, Internal Medicine, Virology, Pediatrics, Medical Microbiology and Infection Prevention, AII - Infectious diseases, Global Health, Infectious diseases, APH - Aging & Later Life, Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Internal medicine, VU University medical center, Surgery, AMS - Rehabilitation & Development, APH - Quality of Care, Psychiatry, Pediatric surgery, Neurology, Public and occupational health, APH - Mental Health, Pathology, Cardiology, ACS - Heart failure & arrhythmias, Anesthesiology, IOO, Rehabilitation medicine, Obstetrics and gynaecology, General practice, Gastroenterology and hepatology, Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, Medical oncology laboratory, Hematology, Epidemiology and Data Science, Physiology, Microbes in Health and Disease (MHD), University of Oxford, Stichting HIV Monitoring [Amsterdam], Universiteit van Amsterdam (UvA), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Amsterdam UMC - Amsterdam University Medical Center, The Wellcome Trust Sanger Institute [Cambridge], Karolinska Institutet [Stockholm], Robert Koch Institute [Berlin] (RKI), Ecole Polytechnique Fédérale de Lausanne (EPFL), Johns Hopkins University (JHU), Universität Zürich [Zürich] = University of Zurich (UZH), Helsinki University Hospital [Helsinki, Finlande], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, University College of London [London] (UCL), Kymab Ltd, Cambridge, England, Institut Pasteur [Paris] (IP), This study was funded by ERC Advanced Grant PBDR-339251 and a Li Ka Shing Foundation grant, both awarded to C.F. The ATHENA Cohort is managed by Stichting HIV Monitoring and supported by a grant from the Dutch Ministry of Health, Welfare and Sport through the Centre for Infectious Disease Control of the National Institute for Public Health and the Environment., We thank K. Fransen and G. Vanham for help with the Belgian data, O. Ratmann for help in identifying the Dutch clusters, K. Kusejko for testing for additional VB individuals in the SHCS, B. Foley for help with genome sharing, B. Dearlove and L. Thomson for help with software, and J. Herbeck and three other reviewers for helpful suggestions., Contributors and affiliations are listed in the supplementary materials., Department of Medicine, University of Helsinki, Infektiosairauksien yksikkö, HUS Inflammation Center, and Clinicum
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Adult ,Male ,HIV-1/genetics ,Genotype ,Anti-HIV Agents ,Evolution ,[SDV]Life Sciences [q-bio] ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,HIV Infections/drug therapy ,selection ,HIV Infections ,Genome, Viral ,heritability ,epidemic ,human-immunodeficiency-virus ,Evolution, Molecular ,SDG 3 - Good Health and Well-being ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Humans ,Viral ,Phylogeny ,Netherlands ,Multidisciplinary ,Genome ,model ,Virulence ,transmission ,Molecular ,setpoint viral load ,reverse-transcriptase ,dynamics ,Viral Load ,CD4 Lymphocyte Count ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,3121 General medicine, internal medicine and other clinical medicine ,Anti-HIV Agents/therapeutic use ,Mutation ,HIV-1 ,Female ,progression - Abstract
Comment in Does HIV-1 virulence matter in the ART era? Lewitus E, Rolland M. Med (N Y). 2022 Apr 8;3(4):217-219. doi: 10.1016/j.medj.2022.03.003. PMID: 35590149; International audience; We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log 10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.
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- 2022
22. The Interplay between Gut Microbiota and the Immune System in Liver Transplant Recipients and Its Role in Infections
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Ancona, Giuseppe, primary, Alagna, Laura, additional, Lombardi, Andrea, additional, Palomba, Emanuele, additional, Castelli, Valeria, additional, Renisi, Giulia, additional, Dondossola, Daniele, additional, Iavarone, Massimo, additional, Muscatello, Antonio, additional, Gori, Andrea, additional, and Bandera, Alessandra, additional
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- 2021
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23. Response
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Grasselli, Giacomo, primary, Scaravilli, Vittorio, additional, Mangioni, Davide, additional, Scudeller, Luigia, additional, Alagna, Laura, additional, Gori, Andrea, additional, and Bandera, Alessandra, additional
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- 2021
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24. Treatment of SARS-CoV-2 relapse with remdesivir and neutralizing antibodies cocktail in a patient with X-linked agammaglobulinaemia
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Palomba, Emanuele, primary, Carrabba, Maria, additional, Zuglian, Gianluca, additional, Alagna, Laura, additional, Saltini, Paola, additional, Fortina, Valeria, additional, Hu, Cinzia, additional, Bandera, Alessandra, additional, Fabio, Giovanna, additional, Gori, Andrea, additional, and Muscatello, Antonio, additional
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- 2021
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25. Fosfomycin therapeutic drug monitoring in real-life: development and validation of a LC-MS/MS method on plasma samples.
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Baldelli, Sara, Cerea, Matteo, Mangioni, Davide, Alagna, Laura, Muscatello, Antonio, Bandera, Alessandra, and Cattaneo, Dario
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- 2022
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26. Mucormycosis in CAPA, a Possible Fungal Super-Infection.
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Saltini, Paola, Palomba, Emanuele, Castelli, Valeria, Fava, Marco, Alagna, Laura, Biscarini, Simona, Mantero, Marco, Blasi, Francesco, Grancini, Anna, Bandera, Alessandra, Gori, Andrea, Muscatello, Antonio, and Lombardi, Andrea
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MUCORMYCOSIS ,MYCOSES ,ASPERGILLUS ,COVID-19 pandemic ,MORTALITY ,IMMUNOSUPPRESSION - Abstract
The occurrence of pulmonary fungal superinfection due to Aspergillus spp. in patients with COVID-19 is a well-described complication associated with significant morbidity and mortality. This can be related to a directed effect of the virus and to the immunosuppressive role of the therapies administered for the disease. Here, we describe the first case of pulmonary infection due to Mucorales occurring in a patient with a concomitant diagnosis of COVID-19-associated pulmonary aspergillosis. [ABSTRACT FROM AUTHOR]
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- 2021
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27. Immune Checkpoint Inhibitors in People Living with HIV/AIDS: Facts and Controversies.
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Castelli, Valeria, Lombardi, Andrea, Palomba, Emanuele, Bozzi, Giorgio, Ungaro, Riccardo, Alagna, Laura, Mangioni, Davide, Muscatello, Antonio, Bandera, Alessandra, and Gori, Andrea
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HIV-positive persons ,IMMUNE checkpoint inhibitors ,AIDS ,HIV infections ,OPPORTUNISTIC infections ,T cells - Abstract
Immune checkpoint inhibitors (ICIs) are reshaping the landscape of cancer treatment, redefining the prognosis of several tumors. They act by restoring the cytotoxic activity of tumor-specific T lymphocytes that are in a condition of immune exhaustion. The same condition has been widely described in chronic HIV infection. In this review, we dissect the role of ICIs in people living with HIV/AIDS (PLWHIV). First, we provide an overview of the immunologic scenario. Second, we discuss the possible use of ICIs as adjuvant treatment of HIV to achieve elimination of the viral reservoir. Third, we examine the influence of HIV infection on ICI safety and effectiveness. Finally, we describe how the administration of ICIs impacts opportunistic infections. [ABSTRACT FROM AUTHOR]
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- 2021
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28. Changes in upper airways microbiota in ventilator-associated pneumonia
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Laura Alagna, Leonardo Mancabelli, Federico Magni, Liliane Chatenoud, Gabriele Bassi, Silvia Del Bianco, Roberto Fumagalli, Francesca Turroni, Davide Mangioni, Guglielmo M. Migliorino, Christian Milani, Antonio Muscatello, Giovanni Nattino, Edoardo Picetti, Riccardo Pinciroli, Sandra Rossi, Tommaso Tonetti, Alessia Vargiolu, Alessandra Bandera, Marco Ventura, Giuseppe Citerio, Andrea Gori, Alagna, L, Mancabelli, L, Magni, F, Chatenoud, L, Bassi, G, Del Bianco, S, Fumagalli, R, Turroni, F, Mangioni, D, Migliorino, G, Milani, C, Muscatello, A, Nattino, G, Picetti, E, Pinciroli, R, Rossi, S, Tonetti, T, Vargiolu, A, Bandera, A, Ventura, M, Citerio, G, Gori, A, Alagna, Laura, Mancabelli, Leonardo, Magni, Federico, Chatenoud, Liliane, Bassi, Gabriele, Del Bianco, Silvia, Fumagalli, Roberto, Turroni, Francesca, Mangioni, Davide, Migliorino, Guglielmo M, Milani, Christian, Muscatello, Antonio, Nattino, Giovanni, Picetti, Edoardo, Pinciroli, Riccardo, Rossi, Sandra, Tonetti, Tommaso, Vargiolu, Alessia, Bandera, Alessandra, Ventura, Marco, Citerio, Giuseppe, and Gori, Andrea
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Mechanical ventilation ,VAP ,Ventilator-associated pneumonia ,16S-rRNA microbial profiling ,Critical Care and Intensive Care Medicine ,Cohort study ,Upper airways microbiota - Abstract
Background The role of upper airways microbiota and its association with ventilator-associated pneumonia (VAP) development in mechanically ventilated (MV) patients is unclear. Taking advantage of data collected in a prospective study aimed to assess the composition and over-time variation of upper airway microbiota in patients MV for non-pulmonary reasons, we describe upper airway microbiota characteristics among VAP and NO-VAP patients. Methods Exploratory analysis of data collected in a prospective observational study on patients intubated for non-pulmonary conditions. Microbiota analysis (trough 16S-rRNA gene profiling) was performed on endotracheal aspirates (at intubation, T0, and after 72 h, T3) of patients with VAP (cases cohort) and a subgroup of NO-VAP patients (control cohort, matched according to total intubation time). Results Samples from 13 VAP patients and 22 NO-VAP matched controls were analyzed. At intubation (T0), patients with VAP revealed a significantly lower microbial complexity of the microbiota of the upper airways compared to NO-VAP controls (alpha diversity index of 84 ± 37 and 160 ± 102, in VAP and NO_VAP group, respectively, p-value Prevotella 7, Fusobacterium, Neisseria, Escherichia–Shigella and Haemophilus) was found in VAP patients. In contrast, eight genera belonging to the Bacteroidetes, Firmicutes and Fusobacteria phyla was predominant in this group. However, it is unclear whether VAP caused dysbiosis or dysbiosis caused VAP. Conclusions In a small sample size of intubated patients, microbial diversity at intubation was less in patients with VAP compared to patients without VAP.
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- 2023
29. Validation of the INCREMENT-SOT-CPE score in a large cohort of liver transplant recipients with carbapenem-resistant Enterobacterales infection.
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Rinaldi M, Bonazzetti C, Gallo M, Ferraro G, Freire M, Terrabuio DRB, Tandoi F, Romagnoli R, De Rosa FG, Mularoni A, Ferrarese A, Burra P, Halpern M, Balbi E, Simkins J, Abbo L, Morrás I, Cantero M, Alagna L, Bandera A, Clemente WT, Valerio M, Fernández A, Muñoz P, Statlender L, Yahav D, Camargo LFA, Girão ES, Grossi P, Viale P, Curti S, and Giannella M
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- Male, Humans, Middle Aged, Female, Carbapenems, Retrospective Studies, Risk Factors, Transplant Recipients, Organ Transplantation adverse effects, Liver Transplantation adverse effects
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Background: Management of infections due to carbapenemase-resistant Enterobacterales (CRE) in solid organ transplant (SOT) recipients remains a difficult challenge. The INCREMENT-SOT-CPE score has been specifically developed from SOT recipients to stratify mortality risk, but an external validation is lacking., Methods: Multicenter retrospective cohort study of liver transplant (LT) recipients colonized with CRE infection who developed infection after transplant over 7-year period. Primary endpoint was all-cause 30-day mortality from infection onset. A comparison between INCREMENT-SOT-CPE and other selected scores was performed. A two-level mixed effects logistic regression model with random effects for the center was fitted. Performance characteristics at optimal cut-point were calculated. Multivariable Cox regression analysis of risk factors for all-cause 30-day mortality was carried out., Results: Overall, 250 CRE carriers developed infection after LT and were analyzed. The median age was 55 years (interquartile range [IQR]: 46-62) and 157 were males (62.8%). All-cause 30-day mortality was 35.6%. A sequential organ failure assessment (SOFA) score ≥ 11 showed a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of 69.7%, 76.4%, 62.0%, 82.0%, and 74.0%, respectively. An INCREMENT-SOT-CPE ≥ 11 reported a sensitivity, specificity, PPV, NPV, and accuracy of 73.0%, 62.1%, 51.6%, 80.6% and 66.0%, respectively. At multivariable analysis acute renal failure, prolonged mechanical ventilation, INCREMENT-SOT-CPE score ≥ 11 and SOFA score ≥ 11 were independently associated with all-cause 30-day mortality, while a tigecycline-based targeted regimen was found to be protective., Conclusions: Both INCREMENT-SOT-CPE ≥ 11 and SOFA ≥ 11 were identified as strong predictors of all-cause 30-day mortality in a large cohort of CRE carriers developing infection after LT., (© 2023 The Authors. Transplant Infectious Disease published by Wiley Periodicals LLC.)
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- 2023
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30. Hospital acquired infections in COVID-19 patients in sub intensive care unit: analysis of two waves of admissions.
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Castaldi S, Perrone PM, Luconi E, Marano G, Auxilia F, Maraschini A, Bono P, Alagna L, Palomba E, Bandera A, Boracchi P, and Biganzoli E
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- Humans, Female, Aged, SARS-CoV-2, Intensive Care Units, Hospitalization, Hospitals, Retrospective Studies, COVID-19, Coinfection epidemiology, Cross Infection
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Background and Aim: The pandemic caused by SARS-COV-2 has increased Semi-Intensive Care Unit (SICU) admission, causing an increase in healthcare-associated infection (HAI). Mostly HAI reveals the same risk factors, but fewer studies have analyzed the possibility of multiple coinfections in these patients. The study aimed was to identify patterns of co-presence of different species describing at the same time the association between such patterns and patient demographics and, finally, comparing the patterns between the two cohorts of COVID-19 patients admitted at Policlinico during the first wave and the second one)., Methods: All the patients admitted to SICUs during two COVID-19 waves, from March to June 2020 months and from October to December 2020, were screened following the local infection control surveillance program; whoever manifested fever has undergone on microbiological culture to detect bacterial species. Statistical analysis was performed to observe the existence of microbiological patterns through DBSCAN method., Results: 246 patients were investigated and 83 patients were considered in our study because they presented infection symptoms with a mean age of 67 years and 33.7% of female patients. During the first and second waves were found respectively 10 and 8 bacterial clusters with no difference regarding the most frequent species., Conclusions: The results show the importance of an analysis which considers the risk factors for the possibility of co- and superinfection (such as age and gender) to structure a good prognostic tool to predict which patients will encounter severe coinfections during hospitalization.
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- 2022
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31. Fosfomycin therapeutic drug monitoring in real-life: development and validation of a LC-MS/MS method on plasma samples.
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Baldelli S, Cerea M, Mangioni D, Alagna L, Muscatello A, Bandera A, and Cattaneo D
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- Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents adverse effects, Chromatography, High Pressure Liquid, Fosfomycin administration & dosage, Fosfomycin adverse effects, Humans, Tandem Mass Spectrometry, Time Factors, Anti-Bacterial Agents blood, Drug Monitoring methods, Fosfomycin blood
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Individualization of fosfomycin dosing based on therapeutic drug monitoring (TDM) of plasma concentrations could reduce drug-related adverse events and improve clinical outcome in complex clinical conditions. Quantification of fosfomycin in plasma samples was performed by a rapid ultraperformance liquid chromatography mass spectrometry method. Sample preparation involved protein precipitation with [
13 C3 ]-fosfomycin benzylamine salt as internal standard. The calibration curve ranged from 2 to 800 mg/L. Within- and between-day precision and accuracy, sensitivity, selectivity, dilution integrity, recovery were investigated and the results met the acceptance criteria. In patients, multiple drug dosing (every 6 or 8 hours) or in continuous administration were adopted, resulting in a large interpatient variability in drug concentrations (from 7.4 mg/L and 644.6 mg/L; CV: 91.1%). In critical care patient setting TDM can represent an important tool to identify the best fosfomycin dosing in single patients, taking into consideration clinical characteristics, infection sites and susceptibility of the treated pathogens.- Published
- 2022
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