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Aiming at the problem of non-limit active earth pressure of sand during active displacement of rigid retaining wall, the active failure process of sand under rotating about the base (RB) mode, rotating about the top (RT) mode and translation (T) mode was simulated and analyzed by using PFC 2D . The results show that there are differences in the mobilization of internal friction angle and the soil-wall interface friction angle in soil under different displacement modes. During the active displacement of the retaining wall, the soil failure in RB mode starts from the top of the wall and develops to the foot of the wall. Only the area near the back of the wall appears the principal stress deflection in the soil wedge, and the mobilized value of the internal friction angle in the soil wedge can reach the limit value. In RT mode, the soil failure starts from the foot of the wall to the soil surface along the back of the wall and the sliding surface. The deflection angle of the principal stress in the middle and upper part of the soil wedge behind the wall is large, forming a large principal stress arch, which corresponds to the reduction of the mobilized value of the friction angle in this area relative to the initial internal friction angle. In T mode, the soil failure develops from the top of the wall to the foot of the wall along the back of the wall and from the foot of the wall to the surface of the soil along the slip surface. A small principal stress arch appears in the soil wedge behind the wall, and the mobilized value of the internal friction angle increases from the initial internal friction angle, but it does not reach the limit value. [ABSTRACT FROM AUTHOR]

In order to assess the water resources carrying capacity of the Gansu section of the Yellow River Basin, this paper chose a set of 20 evaluation indicators initially, targeting four distinct secondary regions. Through an analytical process involving sensitivity and correlation assessments, seven indicators that exhibited low sensitivity and high correlation were pruned, culminating in a refined set of 13 indicators. These indicators were systematically organized into four sub-systems of water resources, societal factors, economic aspects, and ecological environment. The composite scores were derived by integrating the entropy weight method with the TOPSIS model. Furthermore, a barrier factor diagnosis model was applied to evaluate the water resources carrying capacity across the four secondary regions. The findings reveal spatial variations in carrying capacity, with the area above Longyangxia station demonstrating the highest capacity, followed by the sections from Longyangxia station to Lanzhou and from Lanzhou to Hekouzhen station, and the lowest capacity observed in the section from Longmen to Sanmenxia station. In terms of temporal trends, barring the area above Longyangxia station, a steady rise in carrying capacity is observed in the remaining three regions. Key factors impeding the water resources carrying capacity in the Gansu section of the Yellow River Basin encompass per capita water availability, water production index, per capita water supply, population density, urbanization rate, and the rate of water usage for ecological environments. Strategic planning of water resources distribution, restructuring water consumption patterns, and synchronizing water resources carrying capacity with economic growth are instrumental in enhancing and sustaining the carrying capacity of the Gansu section of the Yellow River Basin. [ABSTRACT FROM AUTHOR]

Objective To investigate the expression changes of histone deacetylase 7（HDAC7） and ubiquitin-specific peptidase 10（USP10） in non-small-cell lung cancer （NSCLC） tissues and their significance. Methods Ninety-eight NSCLC patients underwent tumor resection, with cancer tissues and adjacent tissues preserved during the operation. Immunohistochemistry was used to detect the expression of HDAC7 and USP10 in tissues. Spearman correlation analysis was used to analyze the correlation between HDAC7 and USP10 expression in NSCLC cancer tissues, and to analyze the relationships between HDAC7 and USP10 expression and the clinicopathological parameters of NSCLC patients. Kaplan-Meier survival curve was used to analyze the relationship between HDAC7 and USP10 expression and the prognosis of NSCLC patients, and the COX multivariate proportional hazard model was used to analyze the factors for the prognosis of NSCLC patients. Results The positive rates of HDAC7 in the NSCLC tissues and adjacent tissues were 65. 31% （64/98） and 6. 12% （6/98), respectively （χ2 =74. 756, P<0. 05). The positive rates of USP10 in the NSCLC tissues and adjacent tissues were 63. 27% （62/98） and 8. 16% （8/98), respectively （χ2 =64. 800, P<0. 05). The positive expression rates of HDAC7 and USP10 in cancer tissues with stage III NSCLC, low tumor differentiation, and lymph node metastasis were higher than those with TNM stage Ⅰ–Ⅱ, high and medium differentiation, and no lymph node metastasis （all P<0. 05). The expression of HDAC7 and USP10 in NSCLC cancer tissues showed a significant positive correlation （r=0. 714, P<0. 05). The 3-year cumulative survival rates of HDAC7 positive and USP10 positive patients were lower in comparison with those of HDAC7 negative and USP10 negative patients （ χ2 =16. 300, 15. 870, respectively； all P<0. 05). Positive HDAC7 expression, positive USP10 expression, poorly differentiated tumor, lymph node metastasis, and TNM stage III were independent risk factors for the prognosis of NSCLC patients. Conclusion HDAC7 and USP10 are highly expressed in NSCLC tissues, HDAC7 and USP10 may synergistically promote the development and progression of NSCLC, and the prognosis of NSCLC patients with high expression levels of HDAC7 and USP10 is poor. [ABSTRACT FROM AUTHOR]

In recent years, the additional mass method has been gradually applied to nondestructive testing of the compacted density of rockfill. Based on existing research results, it conducted an additional mass method impact factor test on the main rockfill material and transition material of the upper reservoir of Henan Xinhua Wuyue Pumped Storage Power Station by taking into account the five test factors of the dominant frequency of the geophone, the drop distance and offset distance of the hammer, the magnitude of the additional mass and the levels of the additional mass. The test results show that the particle size change of the rockfill material has a significant impact on the selection of the additional mass method test parameters, This is mainly related to the lithology, grading, and stiffness of the rockfill. In order to improve the reliability of the additional mass method, before conducting the additional mass method test, it is necessary to first conduct the additional mass method parameter calibration test on the test rockfill. [ABSTRACT FROM AUTHOR]

Aiming at solving the problem that rapid increase of time delay in data synchronization within existing mimic storage architecture, which led to the performance degradation during system security scheduling. This paper proposed a pre-synchronization model that enabled standby executors to utilize checkpoints in heterogeneous pools for data pre-synchronization, thereby reducing the time required for the executor to go online. Furthermore, according to the synchronization characteristics of the pre-synchronization model and the switching scheduling situation, this paper designed an execution cycle maximum efficiency checkpointing (CMEC) method. This method can determine the optimal checkpoint interval by maximizing the effective work rate of each execution cycle, balancing checkpoint overhead and rollback overhead. The experiments show that, compared with the existing full-volume synchronization strategy, this method shortens the synchronization time required for the executor to go online, improves the synchronization efficiency and ensures the stability and continuity of the system under increasingly heavy business loads [ABSTRACT FROM AUTHOR]

AIM: To establish a method for isolating and culturing primary rat brain microvascular endothelial cells (BMECs) with high purity using the differential sieving technique. METHODS: Brain tissue from 4-week-old SD rats was minced, passed through a cell strainer, and digested with type II collagenase to obtain brain microvascular segments, which were then placed in a C02 incubator for primary culture. The cells were identified by morphological observation and immunocytochemical staining for von Willebrand factor (vWF). RESULTS: After 24 h of culture, short spindle-shaped endothelial cells migrated out from the microvascular segments. Forty-eight hours later, the cells formed islandlike colonies. After 72 h, the cells covered the bottom of the container and exhibited a typical cobblestone-like pattern. Immunocytochemical staining for vWF showed brownish-red cytoplasm, indicating positive expression. CONCLUSION: The differential sieving method can successfully isolate and culture primary rat BMECs with exceptional purity. [ABSTRACT FROM AUTHOR]

Objective: To develop and validate a risk prediction model for severe DPN in patients with type 2 diabetes using glucose variability parameters, and to provide the evidence for the prevention and treatment of diabetic chronic complications. Methods　The medical records from 323 inpatients with T2DM who met the inclusion criteria were collected in the First Affiliated Hospital of Kunming Medical University from April 2019 to May 2020. Based on the professional sensory threshold measured, patients were divided into none-sever DPN group and severe DPN group. Lasso regression model was used to select risk factors. A risk prediction models for severe DPN was established and shown as a nomogram. ROC curve, calibration curve and decision curve analysis was used to validate the model. Results: Age, smoking, dyslipidemia, HbA1c and TIR were significant predictors of severe DPN in type 2 diabetes patients, and TIR was an independent risk factor for severe DPN. An assessing model discrimination was established by using ROC curves with AUC = 0.653 (95%CI = 0.592 - 0.715, P < 0.05). The Hosmer-Lemeshow test was used to determine the model fit with P value 0.074. Conclusion: TIR can be a significant predictor of the severe DPN in patients with T2DM, and the clinical prediction model established on the basis of TIR has the fair accuracy. It is recommended to actively intervene in the patients with a risk of severe DPN greater than 20% (score > 250) evaluated by the model. [ABSTRACT FROM AUTHOR]

Facial micro-expressions have the characteristics of short duration, small range of motion and only occurs in local areas of the face, which brings great challenges to the accurate recognition of micro-expressions.Aiming at solving these problems, a micro-expression recognition algorithm based on continuous spatiotemporal attention network is proposed.The algorithm consists of two channels: primary and secondary.The primary channel is the continuous spatiotemporal attention module and the secondary channel is the position calibration module.Firstly, the main channel is discretely sampled, and the original video frames are extracted at equal intervals to form a new video sequence.The motion difference between each frame is extracted by the inter frame difference method, and then it is input into the continuous spatiotemporal network to extract the motion spatiotemporal features of facial muscles.Secondly, the position of the main channel information is calibrated by using the facial position information extracted by the sub channel.Finally, the classifier Softmax is input to classify the micro-expression.Experiments show that the average recognition accuracy of the algorithm is 89.96%,86.73% and 89.76% respectively on three micro-expression data sets, which is higher than other existing algorithms. [ABSTRACT FROM AUTHOR]

In order to explore the water resources green efficiency in cities of nine provinces (regions) of the Yellow River Basin, based on the SBM-DEA model and Tobit model, the spatial-temporal patterns and influencing factors of water resources green efficiency in 99 prefecture-level cities in nine provinces (regions) of the Yellow River Basin were analyzed. The results show that a) the overall water resources green efficiency in nine provinces (regions) of the Yellow River shows a stable rising trend, the lower reaches enjoy the highest average annual efficiency, the lower reaches of the Central Plains Urban Agglomeration and the Shandong Peninsula Urban Agglomeration rank the top, while the upper reaches of the Lanzhou-Xining Urban Agglomeration and along the Yellow River in Ningxia Urban Agglomeration are relatively poor. b) The water resources green efficiency in nine provinces (regions) of the Yellow River has a significant spatial agglomeration distribution, and the cities with high efficiency are mainly concentrated in the economically developed and main grain-producing provinces in the lower reaches. The water resources green efficiency shows a significant positive spatial autocorrelation with agglomeration and spillover effect. c) The scale of the primary and tertiary industries, water resources endowment and water-saving level have positive effects on the water resources green efficiency, while foreign direct investment has a negative effect. [ABSTRACT FROM AUTHOR]

In order to study the long-term mechanical properties of dry hot rocks in thermal reservoir, the time-dependent micromechanical deformation of granite was studied by grid micro-indentation creep test. The results show that the indentation points of granite show obvious creep deformation under constant load. The fractional Maxwell model composed of spring elements and Abel pot in series can describe the time-dependent deformation of granite under constant pressure. The relationship between the micromechanical parameters obtained by grid micro-indentation test and the composition and macro mechanical parameters of granite is not clear, which needs further study. At the same time, as a new quantitative evaluation method of rock micromechanical properties, micro-indentation test technology has a good application prospect in rock mechanical parameters assessment. [ABSTRACT FROM AUTHOR]

Hydrolysis and polycondensation (and hence crosslinking) of the organosilicon functional group in synthesis reactions is a technical problem that is often encountered. To solve this problem, a new organolsilicate polymer (ADMOS) was developed through emulsion polymerization with monomers such as acrylic acid (AA), vinylmethyldimethoxysilane (VMDS) and methacryloxy ethyl trimethyl ammonium chloride (DMC). 2,2'-azobis(isobutyronitrile) (ABIN) was used as initiator in the polymerization reaction. The optimum synthesis conditions are: molar ratio of the monomers AA∶DMC = 3∶1, the concentration of VMDS id 5.0% of the total mass of the monomers, the concentration of ABIN = 0.3%, the reaction temperature = 70 ℃, the total concentration of the monomers = 25%. and pH = 5. Using ¹H-NMR, TGA and GPC, the molecular structure of ADMOS was determined. TGA measurement showed that ADMOS has excellent thermal stability. The inhibitive capacity of ADMOS was tested using linear expansion test, hot rolling test and mud ball immersion test. Liner expansion test results showed that the linear rate of expansion of clay cores was reduced from 83.37% measured by immersing the cores in water to 16.57% measured by immersing the clay cores in 3% ADMOS solution. Hot rolling test with water and 3% ADMOS solution showed that the percent recovery of shale cuttings was increased from 11.82% to 92.85%. Mud ball test showed that ADMOS can effectively hinders the invasion of water molecules into the interior of the mud balls, thereby inhibiting the hydration and dispersion of the clays. The inhibition mechanisms of ADMOS were revealed from a microscopic perspective through Zeta potential measurement, XRD, EDS, AFM and combined IR-TGA analyses. [ABSTRACT FROM AUTHOR]

Objective To systematically evaluate the development of auditory and language in children with inner ear malformation after cochlear implantation, in addition, to compare and analyze the differences of auditory and language development between these children and children with normal inner ear structure. Methods The 52 children with unilateral cochlear implantation were retrospectively selected and analyzed, they were divided into abnormal inner ear structure group and normal inner ear structure group according to whether the inner ear structure was abnormal or not, with 26 cases in each group. The auditory and language development of the two groups were compared and analyzed before operation, the 1st month, 3 rd month, 6 th month and 12th month after operation. The auditory function was assessed with CAP and ITMAIS scales, while the language function was assessed with SIR and MUSS scales. Results At the 1st month, 3 rd month, 6 th month and 12th month after cochlear implantation, the scores of auditory and language development (CAP, ITMAIS, SIR and MUSS) were significantly different from those before cochlear implantation, which has showed a gradually increasing trend. The auditory function of normal inner ear structure group and abnormal inner ear structure group were compared before operation, the 1st month, 3 rd month, 6 th month and 12th month after operation, there was statistical significant difference (P < 0.001). There was no significant difference between the normal inner ear structure group and the abnormal inner ear structure group in the preoperative language function SIR score (P = 0.303), however, there were significant differences in language function between the two groups at the 1st month, 3 rd month, 6 th month and 12th month after operation (P < 0.05). Conclusion Within one year after cochlear implantation, the auditory and language ability of children with inner ear malformation has been significantly improved, however, there are some differences between the children with abnormal inner ear structure and those with normal inner ear structure. [ABSTRACT FROM AUTHOR]

Osteoporosis is a common chronic disease leading to osteopenia, reduced strength, bone pain and fragile fractures. It affects the health of most middle-aged and elderly people worldwide. Calcium, vitamin D supplements, bisphosphonates, estrogens and other medications are used to focus on preventing and delaying bone resorption. Osteoporosis requires targeted therapeutics that are precise in cell dynamics and differentiation. Through continuous exploration and study of the signaling pathways involved in osteoporosis, we found that Wnt/β-catenin is extremely important in normal bone growth and metabolism. β-catenin is a key molecule mediating the survival and differentiation of osteoblasts. New drugs such as Romozumab and Denosumab are involved in the regulation of osteoporosis by regulating the activity of Wnt/β-catenin signaling pathway, which affects the osteogenesis of BMSC, the proliferation and differentiation of osteoblasts and the generation of osteoclasts. This article summarizes the specific role of β-catenin in the regulation of osteoblasts, osteoclasts and osteoporosis. We explore the research progress of Wnt proteins and β, catenin in order to discover more innovative targets for the treatment of osteoporosis. [ABSTRACT FROM AUTHOR]

Long term gridded meteorological data in 1961-2018 was used in this study instead of in situ observation in previous studies. The spatial and temporal patterns of frost identification thresholds, frost occurrence frequency and frost intensity in the mainland China were investigated through trend analysis and cluster analysis, in order to use climate resources under climate change and reduce the losses caused by frost disasters to agricultural production. The main results were as follows, (1) for screen threshold for frost hazards, the frost date information including first frost date, last frost date and frost free days was detected with detailed geographically spatial pattern and reasonable spatial feature in the threshold of daily 2m minimum air temperature of 0°C than the ones detected by the threshold of daily 2m minimum air temperature of 2°C. (2) In 1961-2018, first frost date in most China was generally delayed (l-3d- 10y_1), and last frost date is advanced. Both of them induced the frost-free days5 increase (l-3d-10y_1). (3) The annual frequency of different frosts intensities had a weakly increased in northern China and obviously decreased in southern China. And the annual frequency of spring frost in different intensities was higher than that of autumn frost in different intensities. (4) The frost hazard's regionalization clustered by frost date and frequency of frost intensity had five sub-regions, which were subtropical zone, warm tropical zone, middle temperate zone, cold temperate zone, and Qinghai-Tibet Plateau zone. In these sub-regions, the Qinghai-Tibet plateau zone had the most dramatic variation in frost dates. Generally, the warming trend in China had a significant weakening effect on the occurrences of frost damage in time, space and intensity. [ABSTRACT FROM AUTHOR]

We used the first - principles method based on density functional theory to calculate the crystal structures, electronic structures, optical properties and phonon spectra of α - Si3N4 and β - Si3N4• The obtained results have been theoretically analyzed. The calculated results show that both phases contain strong covalent bonds and are insulators. The band gap of α - Si3N4 is slightly larger than that of β - Si3N4• The calculated optical absorption coefficients show that α - Si3N4 and β - Si3N4 mainly absorb ultraviolet light, and their energy loss peaks are around 24. 4 eV. In the phonon spectra, α - Si3N4 and β - Si3N4 have no imaginary frequency, indicating that they are stable. In the range of 0 - 1000 K, the heat capacity of α - Si3N4 is about twice that of β - Si3N4 . The calculated results in this paper will provide a theoretical basis for the related applications of Si3N4. [ABSTRACT FROM AUTHOR]

Fagopyrum tatari-cymosum is a semi-perennial new buckwheat type developped from the hybridization between F. tataricum and F. cymosum. To explore the genetic laws of agronomic and quality traits of F. tatari-cymosum, 26 lines of F. tatari-cymosum were selected as materials, and their quality traits and agronomic traits were analyzed by variance analysis, correlation analysis and cluster analysis. The results were as follows: (1) The variation coefficient for quality traits of F. tatari-cymosum was gliadin content ＞ glutenin content ＞ flavonoids content ＞ total protein content ＞ globulin content ＞ albumin content＞starch content. (2) The variation coefficient for agronomic traits of F. tatari-cymosum was branch number of main stems ＞ node number within 20 cm of the bases ＞ main stem diameter ＞ grain area ＞ 1 000-grain weight ＞ node number of main stems ＞ plant height ＞ grain length to width ratio ＞ grain width ＞ grain length ＞ shell rate ＞ grain perimeter ＞ grain diameter. (3) In the correlation analysis, the flavonoid content was significantly positively correlated with albumin content; the gliadin content was significantly or extremely significantly positively correlated with the main stems diameter, the node number of main stems, the node number within 20 cm of the bases, and significantly or extremely significantly negatively correlated with the 1 000-grain weight, grain area, grain perimeter, grain width, and grain diameter; the starch content was positively correlated with grain area, grain length and grain diameter. (4) By cluster analysis, 26 F. tatari-cymosum lines were divided into three groups. Group I belonged to high starch, short stem, multi branched, low shell rate, large long grain lines, which could be used as parent material for breeding purposes of high starch and low shell rate; Group Ⅱ belonged to high protein, high stem, thick, small grain type lines, which could be used as a material for breeding purposes of high protein and strong stress resistance; Group Ⅲ belonged to high quality, high yield, large grain type lines. The results provide theoretical references for the breeding of F. tatari-cymosum. [ABSTRACT FROM AUTHOR]

As the main technology to reduce the risk of casualties in helicopter crash, airbag can effectively reduce the secondary injuries of pilots in the process of crash, but there are few researches on this technology in China. A certain type of helicopter was taken as the research object, and the matching design of airbag folding and restraint system was carried out according to the requirements of automobile crash test, and the finite element simulation model of cockpit complete machine was established. The effectiveness of the model was verified by airbag static initiation test and helicopter complete machine drop crash test. The main structural optimization parameters were determined by sensitivity analysis, and four-factor and four-level orthogonal tests were designed to optimize the constraint system. The results show that the comprehensive damage value (WIC) of pilots is reduced by 8. 91%, and the protective effect of pilots is improved, which provides the research basis for the passive safety field of helicopters. [ABSTRACT FROM AUTHOR]

In the utilization of fluid media to generate power with hot dry rock（HDR）, the rock layers with different temperature gradients generally produce alternating temperature changes. Therefore, studying the permeability of rocks under the effects of cyclic high temperature conditions can help enhance its utilization efficiency. By experimentally exploring granite’s gas permeability under the effect of cyclic high temperature cooling（HTC, carried out at 400 ℃ and 600 ℃）, the influences of factors such as temperature, number of cycles, cooling methods and confining pressures on fluid transmission within granite were discussed, on which basis the evolutionary pattern of granite’s gas permeability under cyclic HTC was analyzed from different perspectives. The results show that as the number of cycles and temperature increased, the deterioration experienced by the rock specimens also become significant. Moreover, it is also found that the deterioration levels caused by high temperature quenching are serious higher than cooling by radiation. Rock damage peaks in severity after the first round of HTC, with mass loss taking up about half of the total mass loss after 6 cycles. Furthermore, the apparent permeability of the rock specimens also increases by two orders of magnitude (from 10-18 m~2 to 10-16 m²) after 2 cycles. At the 4th and 6th cycles, the growth of apparent permeability slows down under high temperature quenching, but changes are negligible when cooled by radiation. [ABSTRACT FROM AUTHOR]

目的　探讨1例RNU4ATAC基因突变导致小头骨发育不良原始侏儒症I型综合征的临床特征、基因突变 特点。方法　回顾性分析 1例 RNU4ATAC基因新生突变导致小头骨发育不良原始侏儒症 I型综合征的临床资料， 总结其临床表型，对基因突变特点进行分析，并复习相关文献。结果　先证者为男童，1 月 27 天，系“发热、咳嗽 2 天，呻吟半天”就诊，头围31 cm，小头畸形，小颌畸形，耳位低平，皮肤干燥，毛发稀疏，双眼突出，对受检者家系临床 全外显子组及毗邻剪接区域进行基因变异分析，发现受检者携带编码小核RNA (snRNA) 基因RNU4ATAC上的2个 杂合变异，即 M1：n. 51G>A 和 M2：n. 55G>A。测序结果显示这两个变异分别遗传自母亲和父亲，构成复合杂合变 异，结合患儿临床表现及二代测序结果，最后确诊为小头骨发育不良原始侏儒症Ⅰ型。未予特殊治疗，但随访未再 出现病情加重现象。结论 RNU4ATAC基因突变可导致小头骨发育不良原始侏儒症Ⅰ型，预后不良，目前暂无有 效治疗方案，基因检查可以早期诊断并评估风险。 [ABSTRACT FROM AUTHOR]

目的　探讨急性腔隙性脑梗死（ALCI）患者血清α-突触核蛋白（α-syn）、沉默调节蛋白1（Sirtuin-1）水平与 病情进展、脑白质病变的关系。方法　选择ALCI患者130例，根据病情是否进展分为进展组（n=32）和非进展组（n= 98），根据是否发生脑白质病变分为病变组（n=106）和非病变组（n=24），根据脑白质病变程度可分为轻度病变组 （Fazekas评分1分，n=49）、中度病变组（Fazekas评分2~3分，n=36）、重度病变组（Fazekas评分4~6分，n=21）。用酶联 免疫吸附法检测血清α-syn、Sirtuin-1；用受试者工作特性（ROC）曲线评估血清α-syn、Sirtuin-1对ALCI患者病情进展 的预测价值；用Pearson相关法分析血清α-syn、Sirtuin-1与Fazekas评分的关系。结果　进展组血清α-syn水平高于 非进展组，Sirtuin-1水平低于非进展组（P均<0. 05）；病变组血清α-syn水平高于非病变组，Sirtuin-1水平低于非病变 组（P均<0. 05）。血清α-syn水平随着ALCI患者脑白质病变加重而升高，Sirtuin-1水平随着ALCI患者脑白质病变加 重而降低（P均<0. 05）。Pearson相关分析结果显示，脑白质病变ALCI患者血清α-syn水平与Fazekas评分呈正相关 （r=0. 534，P<0. 05），血清 Sirtuin-1水平与 Fazekas评分呈负相关（r=-0. 526，P<0. 05）。结论　血清 α-syn水平升高、 Sirtuin-1水平降低与ALCI患者病情进展及脑白质病变加重有关。 [ABSTRACT FROM AUTHOR]

Objective To investigate the difference of sperm dynamic parameters in two-time spermatozoa. Methods Forty-eight men who prepared for physical examination were selected in this study. The semen of them were collected after 1 h verses 2- 7 days of ejaculation abstinence. Semen volume, sperm concentration, proportion of forward motile sperm and proportion of straight motile sperm were analyzed by computer-aided sperm analysis system. Sperm dynamic parameters included mean curve motion velocity (VCL), mean linear motion velocity (VSL), mean path motion velocity (VAP), mean sperm yaw amplitude (ALH), mean sperm whig frequency (BCF), mean sperm motion angle (MAD), straightness of motion (LIN), wobble of motion (WOB) and forward motion (STR). The plasma zinc content was determined by 5-Br-PAPS method. Fructose content was determined by hexokinase method. The content of α-glycosidase in seminal plasma was determined by improved Cooper method after liquefaction. The differences of above indexes and the relationship between semen volume, sperm concentration, the proportion of forward motile sperm and the dynamic parameters of sperm were analyzed. Results The semen volume, proportion of linear motility sperm, total sperm, total forward motility sperm, total linear motility sperm, VCL, VAP, BCF, seminal plasma zinc and α-glucosidase levels of the first sperm extraction were higher than those of the second sperm extraction (P＜0.05). There were no significant differences in sperm concentration, forward motility sperm ratio, VSL, ALH, MAD, LIN, WOB, STR and spermatoglycose level between sperm from two times of sperm extraction. The semen volume of the first extraction was positively correlated with BCF, and the semen volume of the second extraction was negatively correlated with VCL, VSL, VAP, ALH, MAD and WOB (P＜0.05). The sperm concentration of the first sperm extraction was positively correlated with BCF, and the sperm concentration of the second sperm extraction was positively correlated with the dynamic parameters of all sperm (P＜0.05). Except the BCF of the first sperm extraction, the proportion of motile sperm in total, first and second sperm extraction was positively correlated with the dynamic parameters of other sperm groups (P＜0.05). The serum zinc, fructose and α-glucosidase of total and first semen were positively correlated with BCF (P＜0.05). The liquid fructose of the second semen was positively correlated with BCF, and the spermatoplasma α - glucosidase was negatively correlated with VCL and VAP (P＜0.05). Conclusion Although the motility of the second semen sample is significantly decreased compared with that of the first time sperm extraction, it does not affect the ability of the motile sperm to bind to eggs, which can be used as an effective supplement to in vitro fertilization. [ABSTRACT FROM AUTHOR]

目的 探讨一种自制的科室用带有报警功能枕头的应用效果。方法 选取该院泌尿外科2020 年11月至2021年11月住院并使用自制的科室用带有报警功能枕头的46例患者作为研究组,对照组选取使用 该报警功能枕头前1年内的51例患者。对照组使用常规的防跌倒措施(悬挂标识、使用床栏、防跌倒坠床健康 宣教、使用约束带等方式)预防跌倒坠床;研究组使用的报警功能枕头是通过在枕头内植入压力传感器,通过压 力传感器对患者头部的压力进行检测,获得压力信号,通过单片机进行判断分析后,控制报警器工作。比较2 组患者跌倒坠床发生率,以及2组患者及家属对护理服务的满意度。结果 研究组患者跌倒坠床发生率 [2.2%(1/46)]显著低于对照组[13.7%(7/51)],差异有统计学意义(P <0.05)。研究组患者和家属对护理服 务的满意度(93.5%)高于对照组(82.3%),差异有统计学意义(P <0.05)。结论 该报警功能枕头可协助护理 人员有效降低住院患者跌倒坠床的发生率,提高护理服务满意度。 [ABSTRACT FROM AUTHOR]

Objective To investigate the outcome of patients with esophagogastric junction cancer undergoing thoracoscopic laparoscopy-assisted Ivor-Lewis resection. Methods Eighty-four patients who were diagnosed with esophagogastric junction cancer and underwent Ivor-Lewis resection assisted by thoracoscopic laparoscopy at the National Cancer Center from October 2019 to April 2022 were collected. The neoadjuvant treatment mode, surgical safety and clinicopathological characteristics were analyzed. Results Siewert type Ⅱ (92.8%) and adenocarcinoma (95.2%) were predominant in the cases. A total of 2 774 lymph nodes were dissected in 84 patients. The average number was 33 per case, and the median was 31. Lymph node metastasis was found in 45 patients, and the lymph node metastasis rate was 53.6% (45/84). The total number of lymph node metastasis was 294, and the degree of lymph node metastasis was 10.6%(294/2 774). Among them, abdominal lymph nodes (100%, 45/45) were more likely to metastasize than thoracic lymph nodes (13.3%, 6/45). Sixty-eight patients received neoadjuvant therapy before surgery, and nine patients achieved pathological complete remission (pCR) (13.2%, 9/68). Eighty-three patients had negative surgical margins and underwent R0 resection (98.8%, 83/84). One patient, the intraoperative frozen pathology suggested resection margin was negative, while vascular tumor thrombus was seen on the postoperative pathological margin, R1 resection was performed (1.2%, 1/84). The average operation time of the 84 patients was 234.5 (199.3, 275.0) minutes, and the intraoperative blood loss was 90 (80, 100) ml. One case of intraoperative blood transfusion, one case of postoperative transfer to ICU ward, two cases of postoperative anastomotic leakage, one case of pleural effusion requiring catheter drainage, one case of small intestinal hernia with 12mm poke hole, no postoperative intestinal obstruction, chyle leakage and other complications were observed. The number of deaths within 30 days after surgery was 0. Number of lymph nodes dissection, operation duration, and intraoperative blood loss were not related to whether neoadjuvant therapy was performed (P>0.05). Preoperative neoadjuvant chemotherapy combined with radiotherapy or immunotherapy was not related to whether postoperative pathology achieved pCR (P>0.05). Conclusion Laparoscopic-assisted Ivor-Lewis surgery for esophagogastric junction cancer has a low incidence of intraoperative and postoperative complications, high safety, wide range of lymph node dissection, and sufficient margin length, which is worthy of clinical promotion. [ABSTRACT FROM AUTHOR]

ObjectiveTo investigate the influencing factors of colorectal polyp canceration, to improve the early diagnosis and treatment of colorectal cancer, and to reduce the incidence. MethodsPatients diagnosed with intestinal polyps during hospitalization in the Department of Gastroenterology, the First Affiliated Hospital of Kunming Medical University from January 2020 to December 2022 were retrospectively selected. Clinical data including gender, age, height, weight, history of smoking, drinking, diabetes and hypertension, family and personal history of bowel cancer, the position, shape, size, number and pathological type of polyps were collected and analyzed. ResultsA total of 4 700 patients were investigated and cancer occurred in 665 cases, with a cancer rate of 14.1%. There was no significant difference in the rate of intestinal polyp canceration in gender, BMI, diabetes mellitus, alcohol consumption or family history of bowel cancer groups （P > 0.05). There were significant differences in intestinal polyp canceration rate among patients in different age groups, hypertension, smoking, history of bowel cancer, different polyp sites, different polyp morphology, different polyp surface conditions, different number of polyps （ single or multiple), and different polyp diameters （ P < 0.05). The results of unconditioned binary Logistic regression analysis showed that age, hypertension, smoking, polyp location, morphology, surface and size were the factors affecting the carcinogenesis of intestinal polyps （P < 0.05). When analyzing the relationship between pathological types and canceration, 5 cases of villous adenoma among 4 700 patients investigated were too few to be included in the analysis, but the number of cases was too small to be included in the analysis. 69 cases were found to be “ adenocarcinoma”, and the pathological types before canceration could not be identified, so they were not included in the analysis. Finally, 4, 626 patients were included in the analysis. The cancer rate of different pathological types was statistically significant （P < 0.05). Pairwise comparison showed that there were differences between the following groups （P < 0.001） ：the cancer rate of tubulovillous adenoma was the highest （42.0%), followed by tubulovillous adenoma （6.1%), and the lowest nonneoplastic polyps （ 0%). Conclusion The most common pathological type of large intestine polyp is tubular adenoma, and the risk of polyp canceration increases with the increase of villi. The endoscopic characteristics of high-risk polyps include locating at rectal and sigmoid colon, lobed surface, type Ⅱ and Ⅲ of Polyp field classification, large diameter polyps. The risk of colorectal polyp canceration was positively correlated with age, and the risk of polyp canceration increased with age, especially over 60 years old. Smoking and high blood pressure are the risk factors for intestinal polyp canceration. [ABSTRACT FROM AUTHOR]

Objective To evaluate the postoperative effect of transnasal endoscopic surgery for sellar lesions with double nasal speculum, and to explore the effectiveness of this nasal speculum. Methods 34 patients with lesions in the sellar region underwent operation using double nasal speculum in Department of Neurosurgery, the First Affiliated Hospital of Harbin Medical University from September 2020 to September 2021. The extent of resection and postoperative nasal complications were followed up. Results 91.2% (31/34) of the patients underwent radical resection and 8.8% (3/34) subtotal resection. Visual acuity improved in 85% of patients at 1 week postoperatively. The patients had no serious postoperative complications. Intraoperative cerebrospinal fluid leakage was 14.7% (5/34), which was repaired with nasal septum mucosal flap, and there was no postoperative cerebrospinal fluid leakage. In two patients, no cerebrospinal fluid leakage was found during surgery, and cerebrospinal fluid rhinorrhea occurred after surgery, and nasal septal mucosal flap repair was performed on the 7th day after 1st surgery. The proportion with patients ventilated within two weeks after surgery was 88.2% (30/34), and the proportion of patients with olfaction 2 weeks after surgery was 17.6% (6/34). The proportion of olfaction 3 months after surgery was 91.2%. Conclusions The dual-nasal speculum can effectively protect the nasal mucosa, reduce the pollution of the nasal mucosa to the lens, and play a very important role in guiding the endoscope and surgical instruments into and out of the nasal cavity, especially for novice endoscopic surgeons. The nasal speculum can guide the endoscope and surgical instruments to reach the operating area accurately and quickly,especially the left nasal cavity without the guidance of the endoscope. In this way,the learning curve of endoscopic surgeons can be shortened,and it is convenient for the surgeon and assistant to complete the operation together. [ABSTRACT FROM AUTHOR]

Objective To investigate the interaction between dyslipidemia and family history of diabetes mellitus on the risk of diabetes mellitus among adults in Hebei Province. Methods This study was a cross-sectional study. Using data from the China Chronic Disease and Risk Factor Surveillance (CCDRFS), residents aged$18 years were selected through multistage clustering sampling from October to December 2018. The data of individual's blood glucose and lipid were collected. Complex weighting was used to estimate the prevalence of diabetes in the subjects. The additive model was used to analyze the interaction between dyslipidemia and family history of diabetes mellitus in adult residents of Hebei Province. The relative excess risk of interaction (RERI), the attributable proportion of interaction (AP), and the synergy index (SI) were calculated to assess the interaction effect on the additive scale. Results A total of 7 725 subjects aged$18 years were finally included in this study, and the prevalence of diabetes mellitus was 13.1%. The results of the model analysis showed that the risk of dyslipidemia residents who had family history of diabetes mellitus was of 5.407 times higher (95%CI 4.306-6.790, P<0.001) than those in the normal group with RERI, AP and SI of 1.224 (95%CI 0.015-2.433), 0.226 (95%CI 0.035-0.417) and 1.384 (95%CI 1.012-1.894), respectively. The residents with high-density lipoprotein cholesterol (HDL-C) and family history of diabetes mellitus group had a 5.398 times greater risk of developing diabetes than those with the normal group (95%CI 3.995-7.294, P<0.001) with RERI, AP and SI of 2.203 (95%CI 0.710-3.696), 0.408 (95%CI 0.231-0.585) and 2.004 (95%CI 1.361-2.951), respectively. Conclusion The exposures of both dyslipidemia and family history of diabetes mellitus could result in an additive interaction effect on diabetes mellitus. [ABSTRACT FROM AUTHOR]

To investigate the core areas of high productivity of Chinese fir and their influence factors, in this study, the improved CASA model was used to estimate the NPP of Chinese fir forests in Fujian Province in 2006, 2011 and 2016 based on remote sensing data, forest resource survey data and meteorological station data, analyze its spatio-temporal differentiation characteristics, and explore its relationship with various impact factors. The results showed that the annual average NPP values of Chinese fir forests in the study area in 2006, 2011 and 2016 were 804. 03, 854. 76 and 884. 46 g/ (m²·a), showing the seasonal characteristics of high summer and low winter. The Chinese fir forests in the hierarchical statistical study area were dominated by medium and high productivity, with the core areas in Nanping and Sanming. The medium and high productivity Chinese fir stand units in three years accounted for 36. 04%, 41. 98% and 45. 60% of the total area of fir forests in Fujian Province. The NPP of Chinese fir forest was significantly positively correlated with annual total precipitation, annual total solar radiation, altitude, slope, soil organic matter, total nitrogen and total potassium, and significantly negatively correlated with annual average temperature, aspect and total phosphorus. The NPP of Chinese fir forest generally increased with the increase of altitude, slope, annual total solar radiation, annual total precipitation and soil organic matter, and decreased with the increase of annual average temperature. The research showed that altitude, slope, annual total solar radiation, annual total precipitation, annual average temperature and soil organic matter were the important factors that affect the NPP of Chinese fir forests in Fujian Province. [ABSTRACT FROM AUTHOR]

The research progress of electrically conductive pressure-sensitive adhesives in the past ten years is reviewed, including curing methods, fillers, and functional design directions of conductive pressure sensitive adhesives. The conductive fillers of conductive pressure sensitive adhesives are discussed, and the future of the product is prospected. It is foreseeable that with the increasing requirements for environmental protection and the rapid development of low-carbon economy, electrically conductive pressure-sensitive adhesives will play a more important role in various fields. [ABSTRACT FROM AUTHOR]

【Objective】To find the optimum nitrogen application rate of Brassica oleracea var. capitata for high efficient cultivation in the cold area of central Inner Mongolia.【Methods】The total amount control experiment of nitrogen fertilizer for Brassica oleracea var. capitata was conducted in Wuchuan County, Inner Mongolia. Using Zhonggan 628 as the experimental variety, five different nitrogen application treatments were set up, including nitrogen free zone (T1), 70% optimized nitrogen zone (T2), optimized nitrogen zone (T3), 130% optimized nitrogen zone (T4) and 160% optimized nitrogen zone (T5). The yield, commercial net vegetable rate, commercial characters and economic benefits of Brassica oleracea var. capitata under different treatments were compared and analyzed.【Results】The commercial net vegetable yield of T4 treatment was the highest at 96 878.8 kg/hm², followed by T3 treatment at 96 313.1 kg/hm², and increased by 27.78% and 27.03% respectively compared with T1 treatment. The commercial net vegetable rate of T3 treatment was the highest at 78.24%, followed by T2 treatment at 77.32%. The plant development increased as the nitrogen fertilizer application increased, with T5 treatment having the highest growth at 42.78 cm, 18.24% higher than T1 treatment. The single bulb weight of commercial plant in T4 treatment was the highest at 2.10 kg, followed by T3 treatment at 1.99 kg, 33.76% and 26.75% higher than that in T1 treatment, respectively. The net income added value of T3 treatment was the highest at 21 644.6 yuan/hm², with a production ratio of 1.0∶7.4, followed by T4 treatment at 21 455.0 yuan/hm², with a production ratio of 1.0∶5.6. The agronomic efficiency of nitrogen fertilizer in T3 treatment was the highest at 45.54 kg/kg, followed by T4 treatment at 36.00 kg/kg.【Conclusion】In order to promote the reduction of nitrogen fertilizer and increase nitrogen use efficiency, the optimal nitrogen fertilizer application rate of Brassica oleracea var. capitata in the cold area of central Inner Mongolia was 450 kg/hm². [ABSTRACT FROM AUTHOR]

运用第五代移动通信技术（fifth generation, 5G）的低延时、高速率特点和区块链技术的去中心化、不可纂改特点, 构建危重新生儿转运信息系统, 实现了医疗资源和医疗数据共享, 保障转运间医疗服务连续性, 加强转运途中的实时急救指导。复旦大学附属儿科医院建设了5G+区块链的危重新生儿转运信息平台, 设计融合5G数据传输功能的新生儿转诊舱, 建立了转出医院、医疗急救中心、接诊医院三位一体的危重新生儿急救转诊网络体系。所有危重新生儿转运中照护前移, 实现了“上车即入院”, 提升了危重新生儿转运质量。 [ABSTRACT FROM AUTHOR]

Phytophthora strawberries, as a kind of plant pathogenic fungi, can cause strawberry skin and crown rot without safe and effective treatment, which affect the economic benefits of planting strawberries. Therefore, it is urgent to use low-cost diagnostic methods to achieve early prevention. Strawberry plants infected with Phytophthora cactorum would release a unique organic volatile gas, 4-ethylphenol, with a concentration ranging from 1.12 to 22.56 mg/kg, which could be used as a marker gas for rapid diagnosis of the disease. In this study, semiconducting single-walled carbon nanotubes (SWNT) and field effect sensors (FET) were used to prepare semiconductor field effect gas sensors (SWNT/FET) without selectivity. And then the metal porphyrin MnOEP with high sensitivity and selectivity to 4-ethylphenol was immoblized on the SWNT's surface to obtain MnOEP-SWNT/FET. MnOEP-SWNT/FET has the advantages of low cost, low power consumption, small size, high sensitivity and easy integration, which can effectively overcome the shortcomings of gas chromatography-mass spectrometry, high-performance liquid chromatography and other analytical methods. By comparing the sensitivity and selectivity of different sensors, MnOEP-SWNT/FET is very suitable for real-time monitoring of 4-ethylphenol. The key reasons for the high sensitivity and selectivity are: MnOEP is a macromolecular heterocyclic compound formed by four pyrrole rings connected together by methylene and manganese ion(Mn), each pyrrole ring consists of four carbons and one nitrogen, and all nitrogen atoms inside the ring form a central cavity; the coordination metal ions of MnOEP are in an unsaturated state, gas molecules can interact with the central metal ions through van der Waals force and hydrogen bond at the axial position of MnOEP to change their own optical or electrical properties. MnOEP-SWNT/FET was studied by Raman spectrum, UV spectrum and voltammetry. The physical and chemical properties were analyzed and the detection conditions were optimized to improve the gas sensitivity of MnOEPSWNT/ FET to 4-ethylphenol. Under the optimal detection conditions, MnOEP-SWNT/FET has a good linear relationship with 0.25% ~100% saturated vapor of 4-ethylphenol (20 ℃) and the detection limit is 0.15% saturated vapor of 4-ethylphenol. The relative standard error of different concentrations was less than 10%. By measuring the actual samples, it has high detection accuracy for strawberry plants infected with Phytophthora, but it still exists false positive for healthy strawberry [ABSTRACT FROM AUTHOR]

Microbially induced calcium carbonate precipitation (MICP) can significantly improve the engineering mechanical properties of granite residual soil, but its solidification effect is greatly affected by the clay content. MICP curing test was carried out by adding different clay particles in granite residual soil. The calcium carbonate content of solidified soil samples was measured, and the unconfined compressive strength test was carried out to study the effect of different clay content on the curing effect. On this basis, nuclear magnetic resonance (NMR) test was carried out to study the curing mechanism of clay content on granite residual soil from the microscopic point of view. The results show that the strength of microbial solidified soil samples mainly includes the strength of soil skeleton and the strength of calcium carbonate cementation. The former is affected by the porosity of soil itself, and the latter affects the strength of solidified soil samples through the deposition of calcium carbonate crystals. With the increase of clay content, the porosity in the test soil sample is reduced, and the deposition of calcium carbonate is also reduced, and the strength after increase significantly. Adding appropriate amount of red clay (optimal clay content is 60%) can obtain higher curing strength without changing other properties of soil samples. [ABSTRACT FROM AUTHOR]

Traditional data update synchronization tends to update the entire file directly at a time or selectively update local changes. Although the latter method saves part of the communication bandwidth, but every time the file changes, no matter how much change is immediately updated, increasing the communication load, these two methods are not very good to meet the real-time requirements of the industrial Internet. Aiming at this problem, this paper proposed an end-to-end cloud collaborative data synchronization scheme for industrial Internet. In this scheme, it judged the threshold by calculating the difference file. If the value was within the threshold, the changed data blocks were encoded and compressed and uploaded to the corresponding cloud storage node for decompression storage. Otherwise, relevant information would be temporarily stored in the edge layer. Compared with RS encoding and Rsync differential algorithm, it can be seen that the proposed scheme improves the transmission efficiency of updated data, and improves the security through coding compression, and the overall performance is better than other methods. [ABSTRACT FROM AUTHOR]

The bed shear stress under the action of waves is one of the important essential parameters to estimate the incipient motion and transport of offshore sediment, and its bottom friction effect will also have an impact on the offshore hydrodynamic environment. Due to the difficulty in field observation, the understanding of the wave boundary layer and the bed shear stress under the action of waves is mainly based on indoor experimental observation. This paper reviews the relevant theoretical models and experimental measurement research at home and abroad, sorts the advantages and disadvantages of various research methods and measurement techniques, as well as the application conditions, collates a lot of experimental data from 1970s to now, generalizes and analyzes the existing research results, including the impact of wave nonlinearity, wave breaking and other factors on the bed shear stress, summarizes the limitations of the existing research, and puts forward the future research focuses. Super- large water flume is an important facility to break through the bottleneck in the theoretical study of the layer of wave boundary in the future. The development of high- adaptability underwater two-dimensional shear stress sensor is the key to making a breakthrough in the study of bed shear stress under complex dynamic conditions. [ABSTRACT FROM AUTHOR]

Objective To investigate the correlation between bone mineral density ( BMD) and bone metabolic markers indexes and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus ( T2DM), and to provide scientific evidence for bone health for T2DM patients. Methods Our study included 616 T2DM patients admitted to the Department of Endocrinology of Peking University Shenzhen Hospital from December 2018 to December 2019. Patients were divided into non-DR group ( 452 patients without DR) and DR group ( 164 patients with DR) to compare the gender, age, course of diabetes, BMI, smoking/drinking history, BMD, and bone metabolic markers indexes. Results Compared to those in non-DR group, the course of diabetes was higher, BMD values of T- and Z-score of the lumbar vertebrae L 1 -L4 , the femur, and the femoral neck were lower, the levels of bone metabolic markers (Ca, 24 h urine Ca, and 25 (OH) D3 ) were lower, and the levels of bone metabolic markers ( P and β-CTX) were higher in DR group. The prevalence of abnormal bone mass in T2DM patients with diabetic retinopathy was higher ( 59. 8% vs 50. 2%, OR= 1. 48; 95% Cl: 0. 99 - 2. 22). Conclusion When T2DM patients are complicated with DR, the expressions of bone formation markers and bone resorption markers increase, the rate of bone turnover accelerates, the level of PTH and the activity of osteoclasts increase, BMD decreases, and the prevalence of abnormal bone mass increases. [ABSTRACT FROM AUTHOR]

The incidence and mortality of lung cancer ranked the first in China. China had 787,000 new cases of lung cancer in 2015, and a majority of these patients with advanced lung cancer, With the development and popularization of high-resolution computed tomography, more and more early-stage lung adenocarcinomas are found in screening. The imaging finding of early-stage lung adenocarcinomas often manifests as part solid nodule (PSN) containing ground glass opacity (GGO). Although the imaging manifestation of the nodules can't accurately predict the pathologic type of nodules, the parts of solid nodule and GCO still have some pathologic indications, and the prognostic evaluation effect of the maximum diameter of PSN is superior to that o the whole nodule. With the development of the molecular radiography and molecular pathology, the relationship of imaging manifestation of the PSN and metastasis were focused on. Some PSNs with special nature are more active and rapidly progressed than the pure GGOs. While compared to the pure solid nodules, the aggressiveness of PSNs are insufficient, with lower metastatic rates of lymph node and better prognoses. Currently, international acknowledge recommends to take active intervention measure for PSN which are highly suspected to be maligunt. We focus on the diagnosis and treatment of PSNs, systemically depict their staging, follow-up, surgical treatment, gene detection and immunotherapy. [ABSTRACT FROM AUTHOR]

In this work, Na(La0.97Yb0.02Tm0.01)(WO4)2 up-conversion phosphor is successfully prepared by self-sacrificing template reaction with a rare earth layered compound (La0.97Yb0.02Tm0.01)2(OH)4SO4·2H2O as novel template. The developed process allows the direct preparation of the Na(La0.97Yb0.02Tm0.01)(WO4)2 via the self-sacrificial reaction without subsequent calcination. The synthesized materials are characterized by powder X-ray diffraction, field emission scanning electron microscopy (FE-SEM) and fluorescence spectroscopy. The results show that the pure phase phosphor can be directly produced by reaction at 200 ℃ for 24 h under WO2-4/RE3+ molar ratio of 10. FE-SEM analysis shows that using (La0.97Yb0.02Tm0.01)2(OH)4SO4·2H2O as template, phase-pure double tungstates, whose particles are about 4.6 μm sized micro-disks of favorable dispersion and size uniformity can be obtained without adding any organic reagents. Under the excitation of 978 nm laser, Na(La0.97Yb0.02Tm0.01)(WO4)2 phosphor can emit highly pure near-infrared emission at about 796 nm, which is attributed to the 3H4→3H6 transition of Tm3+ ions. The emission peak at the blue light is almost completely quenched, and the intensity of the near-infrared emission peak is approximately 260 times that of the blue emission peak. Analysis of the UC intensity against excitation power reveals a two-photon mechanism for the phosphor. [ABSTRACT FROM AUTHOR]

Objective To investigate the influence of diabetic microangiopathy on bone mineral density ( BMD) and bone metabolic markers and provide scientific evidence for prevention of osteoporosis (OP) . Methods Our study included 457 type 2 diabetes mellitus ( T2DM) patients ( ~ 50 years) admitted to the Department of Endocrinology of Perking University Shenzhen Hospital from December 2018 to December 2019. According to the diabetic microangiopathy, which involved diabetic neuropathy ( DN), diabetic retinopathy (DR) and diabetic peripheral neuropathy ( DPN), patients were divided into group A ( 160 patients without diabetic microangiopathy), group B ( 297 patients with diabetic microangiopathy) to compare the BMD and bone metabolic markers. Results Compared with group A, the BMD, T-value and Z-value of lumbar vertebrae L1- 4 , femoral neck and femur were lower in group B, the level of lab result ( [3-CTX, PINP, N-MID) were higher and the level of lab result [ 24 h urine Ca, 25 (OH) D3 J were lower ( P< 0. 05). The prevalence of OP in T2DM patients with diabetic microangiopathy was higher ( 8. 8 % vs 20. 9 %, OR = 2. 156; 95% CI: 1. 102 - 4. 220, P < 0. 05). Conclusion When T2DM was complicated with diabetic microangiopathy, the expression of bone formation markers and bone resorption markers increased, the rate of bone turnover accelerated. The level of PTH increased and the activity of osteoclasts increased, BMD decreased while the prevalence of OP increased. [ABSTRACT FROM AUTHOR]