河北省成年居民血脂异常与糖尿病家族史对糖尿病患病的交互作用.

Objective To investigate the interaction between dyslipidemia and family history of diabetes mellitus on the risk of diabetes mellitus among adults in Hebei Province. Methods This study was a cross-sectional study. Using data from the China Chronic Disease and Risk Factor Surveillance (CCDRFS), residents aged$18 years were selected through multistage clustering sampling from October to December 2018. The data of individual's blood glucose and lipid were collected. Complex weighting was used to estimate the prevalence of diabetes in the subjects. The additive model was used to analyze the interaction between dyslipidemia and family history of diabetes mellitus in adult residents of Hebei Province. The relative excess risk of interaction (RERI), the attributable proportion of interaction (AP), and the synergy index (SI) were calculated to assess the interaction effect on the additive scale. Results A total of 7 725 subjects aged$18 years were finally included in this study, and the prevalence of diabetes mellitus was 13.1%. The results of the model analysis showed that the risk of dyslipidemia residents who had family history of diabetes mellitus was of 5.407 times higher (95%CI 4.306-6.790, P<0.001) than those in the normal group with RERI, AP and SI of 1.224 (95%CI 0.015-2.433), 0.226 (95%CI 0.035-0.417) and 1.384 (95%CI 1.012-1.894), respectively. The residents with high-density lipoprotein cholesterol (HDL-C) and family history of diabetes mellitus group had a 5.398 times greater risk of developing diabetes than those with the normal group (95%CI 3.995-7.294, P<0.001) with RERI, AP and SI of 2.203 (95%CI 0.710-3.696), 0.408 (95%CI 0.231-0.585) and 2.004 (95%CI 1.361-2.951), respectively. Conclusion The exposures of both dyslipidemia and family history of diabetes mellitus could result in an additive interaction effect on diabetes mellitus. [ABSTRACT FROM AUTHOR]