1. Real-world Outcomes in Newly Diagnosed Multiple Myeloma Based on Interphase Fluorescent In situ Hybridization: A Retrospective Analysis.
- Author
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Jain, Punit, Jain, Poonam, Tikoo, Agnivesh, Singh, Tejinder, Patkar, Salil, Lokhande, Vaishali, Mishra, Anand, Agarwal, Bharat, Haridas, Ashwathy, and Khandelwal, Kanika
- Subjects
MULTIPLE myeloma diagnosis ,THERAPEUTIC use of protease inhibitors ,COMMUNITY health services ,MULTIPLE myeloma ,CANCER treatment ,RISK assessment ,CYTOGENETICS ,CANCER relapse ,RETROSPECTIVE studies ,CANCER patients ,DISEASE remission ,DESCRIPTIVE statistics ,REMISSION induction ,BORTEZOMIB ,CARBOCYCLIC acids ,KAPLAN-Meier estimator ,LOG-rank test ,FLUORESCENCE in situ hybridization ,MEDICAL records ,ACQUISITION of data ,SEPSIS ,PROGRESSION-free survival ,DATA analysis software ,BIOMARKERS ,SPECIALTY hospitals ,PATIENT aftercare ,OVERALL survival ,INDUCTION chemotherapy ,SUBCUTANEOUS injections - Abstract
Introduction: Limited data exist on interphase fluorescent in situ hybridization (iFISH)-based survival outcomes in newly diagnosed multiple myeloma (NDMM) from India. Objectives: To study the demographics and iFISH-based survival outcomes in NDMM patients treated with proteasome inhibitors from a community-based cancer setup. Materials and Methods: We reviewed the records of 25 patients treated with proteasome inhibitors between June 2017 and April 2023 using five high-risk (HR) iFISH markers based on mSMART 3.0. Results: The median age was 60 years (range 34–87). HR iFISH was detected in 12 (48%) patients. With a median follow-up of 27 months, the overall response at the last follow-up was 80% (very good partial response - 52%, complete remission - 20%, and partial response - 8%), with 8 (32%) relapses. Twenty (80%) patients remain alive, with five deaths in HR (sepsis [ n = 3]). The 2.5-year overall survival in HR and standard risk was 55.6% ± 15.2% and 100% (P = 0.01), and event-free survival was 32.4% ± 16.5% and 77.8% ± 13.8% (P = 0.02), respectively. Conclusions: Using limited iFISH HR markers helps in the early and effective stratification of NDMM in the real world. Sepsis remains an important cause of mortality in an Indian setup. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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