Back to Search
Start Over
Predictors of Myelosuppression for Patients with Head and Neck Squamous Cell Carcinoma After Induction Chemotherapy.
- Source :
-
Clinical Medicine Insights: Oncology . 1/5/2024, p1-12. 12p. - Publication Year :
- 2024
-
Abstract
- Background: Induction chemotherapy (ICT) has become an initial treatment for head and neck squamous cell carcinoma (HNSCC). However, myelosuppression, an unavoidable side effect of ICT, significantly impacts follow-up treatment and prognosis. The main objective of this study is to identify the risk factors and predictors of myelosuppression and its different severity after ICT for ICT. Methods: We retrospectively reviewed medical records of 102 patients with hypopharyngeal cancer or oropharyngeal cancer who received initial ICT from 2013 to 2022. Univariate and multivariate logistic regression analyses were performed to identify risk factors for myelosuppression. Receiver-operating characteristic (ROC) curves were generated using the results of multiple logistic regression analysis to identify data with the highest sensitivity and lowest false-negative rate. Results: Pretreatment lymphocyte count (PLC) and the pretreatment platelet count (PPC) were identified as independent risk factors of myelosuppression (P <.05). Pretreatment hemoglobin count (PHC) was an independent risk factor for predicting myelosuppression in patients with grades III to IV disease. Patients with myelosuppression after ICT are more sensitive to chemotherapy. Conclusions: The PLC and PPC predicted myelosuppression in patients with HNSCC-administered ICT, and the PHC predicted grades III to IV myelosuppression. Myelosuppressed patients were more chemosensitive after ICT. [ABSTRACT FROM AUTHOR]
- Subjects :
- *STATISTICS
*HEMOGLOBINS
*CONFIDENCE intervals
*INFLAMMATION
*MULTIPLE regression analysis
*LOG-rank test
*HEAD & neck cancer
*RETROSPECTIVE studies
*ACQUISITION of data
*OROPHARYNGEAL cancer
*FISHER exact test
*SEVERITY of illness index
*RISK assessment
*CANCER patients
*NEUTROPHILS
*T-test (Statistics)
*TUMOR classification
*COMPARATIVE studies
*MEDICAL records
*PLATELET count
*CHI-squared test
*DESCRIPTIVE statistics
*RESEARCH funding
*TUMOR markers
*BONE marrow diseases
*LOGISTIC regression analysis
*RECEIVER operating characteristic curves
*SENSITIVITY & specificity (Statistics)
*DIAGNOSTIC errors
*DATA analysis software
*ODDS ratio
*INDUCTION chemotherapy
*SQUAMOUS cell carcinoma
*HYPOPHARYNGEAL cancer
*LYMPHOCYTE count
*OVERALL survival
*DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 11795549
- Database :
- Academic Search Index
- Journal :
- Clinical Medicine Insights: Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 174631166
- Full Text :
- https://doi.org/10.1177/11795549231219497