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5. A revised prediction model for natural conception

Author

van Kasteren, Y.M., van der Heijden, P.F.M., Schöls, W.A., Mochtar, M.H., Lips, G.L.M., Dawson, J., Verhoeve, H.R., Milosavljevic, S., Hompes, P.G.A., van Dam, L.J., Sluijmer, A.V., Bobeck, H.E., Bernardus, R.E., Vermeer, M.C.S., Dörr, J.P., van der Linden, P.J.Q., Roelofs, H.J.M., Burggraaff, J.M., Oosterhuis, G.J.E., Schouwink, M.H., Bouckaert, P.X.J.M., Delemarre, F.M.C., Hamilton, C.J.C.M., van Hoven, M., Emanuel, M.H., Renckens, C.N.M., Land, J.A., Schagen-Van Leeuwen, J.H., Kremer, J.A.M., van Katwijk, C., van Hooff, M.H.A., Van Dessel, H.J.H.M., Broekmans, F.J.M., Ruis, H.J.L.A., Koks, C.A.M., Bourdrez, P., Riedijk, W.W.J., Cohlen, B.J., Bensdorp, Alexandra J., van der Steeg, Jan Willem, Steures, Pieternel, Habbema, J. Dik F., Hompes, Peter G.A., Bossuyt, Patrick M.M., van der Veen, Fulco, Mol, Ben W.J., and Eijkemans, Marinus J.C.

Published
2017
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8. Donor sperm treatment: the role of semen parameters in intracervical insemination, a retrospective cohort study.

Author

Kop, Petronella, van Wely, Madelon, de Melker, Annemieke, van der Veen, Fulco, and Mochtar, Monique

Subjects
SEMEN, SEMEN analysis, RETROSPECTIVE studies, ACQUISITION of data, SPERM motility, PRESERVATION of organs, tissues, etc., HUMAN artificial insemination, MEDICAL records, FERTILIZATION in vitro, SPERM donation, LONGITUDINAL method
Abstract

Donor sperm treatment is advised to be performed with frozen-thawed donor semen. A disadvantage of frozen-thawed semen is lower pregnancy rates compared to inseminations with fresh semen. Semen parameters affect ongoing pregnancy rates in intracervical inseminations with frozen-thawed donor semen. In an attempt to translate this into clinical relevance, cohort studies have tried to find cut-off values for semen parameters after thawing for intracervical insemination, but these studies assessed only one semen parameter per study, thereby overlooking the intricate interplay between all semen parameters. We performed a retrospective cohort study and tried to calculate thresholds for all semen parameters that lead to the best possible ongoing pregnancy rates in intracervical insemination with frozen-thawed donor semen. Between April 1999 and December 2015, data from 1,186 women who underwent 7,103 cycles of intracervical insemination with donor semen from 129 sperm donors were available for analysis. Our results showed that total motility and total motile count (TMC) after thawing were associated with ongoing pregnancy rate. The best possible ongoing pregnancy chances after intracervical insemination were obtained at a total motility of ≥20% and a total motile count (TMC) of ≥8 × 106 after thawing. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Gonadotrophins Versus Clomifene Citrate With or Without Intrauterine Insemination in Women With Normogonadotropic Anovulation and Clomifene Failure (M-OVIN): A Randomized, Two-by-Two Factorial Trial

Author

Weiss, Nienke S., Nahuis, Marleen J., Bordewijk, Esmee, Oosterhuis, Jurjen E., Smeenk, Jesper M. J., Hoek, Annemieke, Broekmans, Frank J. M., Fleischer, Kathrin, de Bruin, Jan Peter, Kaaijk, Eugenie M., Laven, Joop S. E., Hendriks, Dave J., Gerards, Marie H., van Rooij, Ilse A. J., Bourdrez, Petra, Gianotten, Judith, Koks, Carolien, Lambalk, Cornelis B., Hompes, Peter G., van der Veen, Fulco, Mol, Ben Willem J., and van Wely, Madelon

Published
2018
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13. The FOAM study: is Hysterosalpingo foam sonography (HyFoSy) a cost-effective alternative for hysterosalpingography (HSG) in assessing tubal patency in subfertile women? Study protocol for a randomized controlled trial

Author

van Rijswijk, Joukje, van Welie, Nienke, Dreyer, Kim, van Hooff, Machiel H. A., de Bruin, Jan Peter, Verhoeve, Harold R., Mol, Femke, Kleiman-Broeze, Kimiko A., Traas, Maaike A. F., Muijsers, Guido J. J. M., Manger, Arentje P., Gianotten, Judith, de Koning, Cornelia H., Koning, Aafke M. H., Bayram, Neriman, van der Ham, David P., Vrouenraets, Francisca P. J. M., Kalafusova, Michaela, van de Laar, Bob I. G., Kaijser, Jeroen, van Oostwaard, Miriam F., Meijer, Wouter J., Broekmans, Frank J. M., Valkenburg, Olivier, van der Voet, Lucy F., van Disseldorp, Jeroen, Lambers, Marieke J., Peters, Henrike E., Lier, Marit C. I., Lambalk, Cornelis B., van Wely, Madelon, Bossuyt, Patrick M. M., Stoker, Jaap, van der Veen, Fulco, Mol, Ben W. J., and Mijatovic, Velja

Published
2018
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14. Fertility preservation for women with breast cancer: a multicentre randomized controlled trial on various ovarian stimulation protocols

Author

Balkenende, Eva M E, primary, Dahhan, Taghride, additional, Beerendonk, Catharina C M, additional, Fleischer, Kathrin, additional, Stoop, Dominic, additional, Bos, Annelies M E, additional, Lambalk, Cornelis B, additional, Schats, Roel, additional, Smeenk, Jesper M J, additional, Louwé, Leonie A, additional, Cantineau, Astrid E P, additional, de Bruin, Jan Peter, additional, Linn, Sabine C, additional, van der Veen, Fulco, additional, van Wely, Madelon, additional, and Goddijn, Mariëtte, additional

Published
2022
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15. Fertility preservation for women with breast cancer: a multicentre randomized controlled trial on various ovarian stimulation protocols

Author

Child Health, MS VPG/Gynaecologie, Cancer, Balkenende, Eva M E, Dahhan, Taghride, Beerendonk, Catharina C M, Fleischer, Kathrin, Stoop, Dominic, Lambalk, Cornelis B, Bos, Annelies M E, Schats, Roel, Smeenk, Jesper M J, Louwé, Leonie A, Cantineau, Astrid E P, Bruin, Jan Peter de, Linn, Sabine C, van der Veen, Fulco, van Wely, Madelon, Goddijn, Mariëtte, Child Health, MS VPG/Gynaecologie, Cancer, Balkenende, Eva M E, Dahhan, Taghride, Beerendonk, Catharina C M, Fleischer, Kathrin, Stoop, Dominic, Lambalk, Cornelis B, Bos, Annelies M E, Schats, Roel, Smeenk, Jesper M J, Louwé, Leonie A, Cantineau, Astrid E P, Bruin, Jan Peter de, Linn, Sabine C, van der Veen, Fulco, van Wely, Madelon, and Goddijn, Mariëtte

Published
2022

17. Randomized Trial of a Lifestyle Program in Obese Infertile Women

Author

Mutsaerts, Meike A.Q., van Oers, Anne M., Groen, Henk, Burggraaff, Jan M., Kuchenbecker, Walter K.H., Perquin, Denise A.M., Koks, Carolien A.M., van Golde, Ron, Kaaijk, Eugenie M., Schierbeek, Jaap M., Oosterhuis, Gerrit J.E., Broekmans, Frank J., Bemelmans, Wanda J.E., Lambalk, Cornelis B., Verberg, Marieke F.G., van der Veen, Fulco, Klijn, Nicole F., Mercelina, Patricia E.A.M., van Kasteren, Yvonne M., Nap, Annemiek W., Brinkhuis, Egbert A., Vogel, Niels E.A., Mulder, Robert J.A.B., Gondrie, Ed T.C.M., de Bruin, Jan P., Sikkema, J. Marko, de Greef, Mathieu H.G., Bogt, Nancy C.W. ter, Land, Jolande A., Mol, Ben W.J., and Hoek, Annemieke

Published
2016
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21. Gonadotrophins or clomiphene citrate in couples with unexplained infertility undergoing intrauterine insemination: a cost-effectiveness analysis

Author

Danhof, Noor A., primary, van Wely, Madelon, additional, Repping, Sjoerd, additional, van der Ham, David P., additional, Klijn, Nicole, additional, Janssen, Ineke C.A.H., additional, Rijn-van Weert, Janne-Meije, additional, Twisk, Moniek, additional, Traas, Maaike A.F., additional, Pelinck, Marie-Louise J., additional, Perquin, Denise A.M., additional, Boks, Dominique E.S., additional, Sluijmer, Alexander, additional, Mol, Ben W.J., additional, van der Veen, Fulco, additional, and Mochtar, Monique H., additional

Published
2020
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22. Interventions for unexplained infertility : a systematic review and network meta-analysis

Author

Wang, Rui, Danhof, Nora A, Tjon-Kon-Fat, Raissa I, Eijkemans, Marinus Jc, Bossuyt, Patrick Mm, Mochtar, Monique H, van der Veen, Fulco, Bhattacharya, Siladitya, Mol, Ben Willem J, van Wely, Madelon, Wang, Rui, Danhof, Nora A, Tjon-Kon-Fat, Raissa I, Eijkemans, Marinus Jc, Bossuyt, Patrick Mm, Mochtar, Monique H, van der Veen, Fulco, Bhattacharya, Siladitya, Mol, Ben Willem J, and van Wely, Madelon

Published
2019

23. Interventions for unexplained infertility: a systematic review and network meta-analysis

Author

Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Wang, Rui, Danhof, Nora A, Tjon-Kon-Fat, Raissa I, Eijkemans, Marinus Jc, Bossuyt, Patrick Mm, Mochtar, Monique H, van der Veen, Fulco, Bhattacharya, Siladitya, Mol, Ben Willem J, van Wely, Madelon, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Wang, Rui, Danhof, Nora A, Tjon-Kon-Fat, Raissa I, Eijkemans, Marinus Jc, Bossuyt, Patrick Mm, Mochtar, Monique H, van der Veen, Fulco, Bhattacharya, Siladitya, Mol, Ben Willem J, and van Wely, Madelon

Published
2019

24. Protect us from poor-quality medical research

Author

Ioannidis, John P. A., Bhattacharya, Siladitya, Evers, J. L. H., van der Veen, Fulco, Somigliana, Edgardo, Barratt, Christopher L. R., Bontempi, Gianluca, Baird, David T., Crosignani, PierGiorgio, Devroey, Paul, Diedrich, Klaus, Farquharson, Roy G., Fraser, Lynn R., Geraedts, Joep P. M., Gianaroli, Luca, La Vecchia, Carlo, Lundin, Kersti, Magli, Cristina, Negri, Eva, Sunde, Arne, Tapanainen, Juha S., Tarlatzis, Basil C., Van Steirteghem, Andre, Veiga, Anna, RS: GROW - R4 - Reproductive and Perinatal Medicine, Obstetrie & Gynaecologie, Klinische Genetica, Ioannidis, John P A, Bhattacharya, Siladitya, Evers, J L H, der Veen, Fulco van, Somigliana, Edgardo, Barratt, Christopher L R, Bontempi, Gianluca, Baird, David T, Crosignani, PierGiorgio, Devroey, Paul, Diedrich, Klau, Farquharson, Roy G, Fraser, Lynn R, Geraedts, Joep P M, Gianaroli, Luca, La Vecchia, Carlo, Kersti Lundin, Magli, Cristina, Negri, Eva, Sunde, Arne, Tapanainen, Juha S, Tarlatzis, Basil C, Steirteghem, Andre Van, and Veiga, Anna

Subjects
Biomedical Research, REDUCING WASTE, media_common.quotation_subject, P-VALUES, BIOMEDICAL-RESEARCH, meta-analysi, medical research, law.invention, 03 medical and health sciences, equipose, 0302 clinical medicine, Randomized controlled trial, law, Humans, Quality (business), 030212 general & internal medicine, METAANALYSES, media_common, OUTCOMES, 030219 obstetrics & reproductive medicine, Information Dissemination, Clinical study design, Rehabilitation, Obstetrics and Gynecology, Medical research, randomized clinical trial, RANDOMIZED-TRIALS, meta-analysis, P-value, SYSTEMATIC REVIEWS, Systematic review, Reproductive Medicine, Risk analysis (engineering), Research Design, Meta-analysis, Transparency (graphic), Observational study, HEALTH, Psychology
Abstract

Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.

Published
2018

27. The AID study: protocol for a randomised controlled trial of intrauterine insemination in the natural cycle compared with intracervical insemination in the natural cycle

Author

Kop, Petronella, primary, van Wely, Madelon, additional, Nap, Annemiek, additional, Willem Mol, Ben, additional, Bernardus, Rob, additional, Brucker, Michael De, additional, Janssens, Pim, additional, Cohlen, Ben, additional, Pieters, Jacqueline, additional, Repping, Sjoerd, additional, van der Veen, Fulco, additional, and Mochtar, Monique H, additional

Published
2019
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29. Association between periconceptional weight loss and maternal and neonatal outcomes in obese infertile women

Author

van Oers, Anne M., Mutsaerts, Meike A.Q., Burggraaff, Jan M., Kuchenbecker, Walter K.H., Perquin, Denise A.M., Koks, Carolien A.M., van Golde, Ron, Kaaijk, Eugenie M., Broekmans, Frank J., De Bruin, Jan Peter, van der Veen, Fulco, Nap, Annemiek W., Gondrie, Ed T.C.M., Mol, Ben W.J., Groen, Henk, Hoek, Annemieke, on behalf of the LIFEstyle study group, van Oers, Anne M., Mutsaerts, Meike A.Q., Burggraaff, Jan M., Kuchenbecker, Walter K.H., Perquin, Denise A.M., Koks, Carolien A.M., van Golde, Ron, Kaaijk, Eugenie M., Broekmans, Frank J., De Bruin, Jan Peter, van der Veen, Fulco, Nap, Annemiek W., Gondrie, Ed T.C.M., Mol, Ben W.J., Groen, Henk, Hoek, Annemieke, and on behalf of the LIFEstyle study group

Published
2018

30. Gonadotrophins versus clomifene citrate with or without intrauterine insemination in women with normogonadotropic anovulation and clomifene failure (M-OVIN): A randomised, two-by-two factorial trial

Author

UMC Utrecht, MS VPG/Gynaecologie, Child Health, Circulatory Health, Weiss, Nienke S., Nahuis, Marleen J., Bordewijk, Esmee, Oosterhuis, Jurjen G E, Smeenk, Jesper M J, Hoek, Annemieke, Broekmans, Frank J.M., Fleischer, Kathrin, de Bruin, Jan Peter, Kaaijk, Eugenie M, Laven, Joop S E, Hendriks, Dave J., Gerards, Marie H., van Rooij, Ilse A J, Bourdrez, Petra, Gianotten, Judith, Koks, Carolien A M, Lambalk, Cornelis B., Hompes, Peter G A, van der Veen, Fulco, Mol, Ben Willem J., van Wely, Madelon, UMC Utrecht, MS VPG/Gynaecologie, Child Health, Circulatory Health, Weiss, Nienke S., Nahuis, Marleen J., Bordewijk, Esmee, Oosterhuis, Jurjen G E, Smeenk, Jesper M J, Hoek, Annemieke, Broekmans, Frank J.M., Fleischer, Kathrin, de Bruin, Jan Peter, Kaaijk, Eugenie M, Laven, Joop S E, Hendriks, Dave J., Gerards, Marie H., van Rooij, Ilse A J, Bourdrez, Petra, Gianotten, Judith, Koks, Carolien A M, Lambalk, Cornelis B., Hompes, Peter G A, van der Veen, Fulco, Mol, Ben Willem J., and van Wely, Madelon

Published
2018

31. Gonadotrophins Versus Clomifene Citrate with or Without Intrauterine Insemination in Women with Normogonadotropic Anovulation and Clomifene Failure (M-OVIN): A Randomized, Two-by-Two Factorial Trial

Author

MS VPG/Gynaecologie, Child Health, Circulatory Health, Weiss, Nienke S., Nahuis, Marleen J., Bordewijk, Esmee, Oosterhuis, Jurjen E., Smeenk, Jesper M.J., Hoek, Annemieke, Broekmans, Frank J.M., Fleischer, Kathrin, De Bruin, Jan Peter, Kaaijk, Eugenie M., Laven, Joop S.E., Hendriks, Dave J., Gerards, Marie H., Van Rooij, Ilse A.J., Bourdrez, Petra, Gianotten, Judith, Koks, Carolien, Lambalk, Cornelis B., Hompes, Peter G., Van Der Veen, Fulco, Mol, Ben Willem J., Van Wely, Madelon, MS VPG/Gynaecologie, Child Health, Circulatory Health, Weiss, Nienke S., Nahuis, Marleen J., Bordewijk, Esmee, Oosterhuis, Jurjen E., Smeenk, Jesper M.J., Hoek, Annemieke, Broekmans, Frank J.M., Fleischer, Kathrin, De Bruin, Jan Peter, Kaaijk, Eugenie M., Laven, Joop S.E., Hendriks, Dave J., Gerards, Marie H., Van Rooij, Ilse A.J., Bourdrez, Petra, Gianotten, Judith, Koks, Carolien, Lambalk, Cornelis B., Hompes, Peter G., Van Der Veen, Fulco, Mol, Ben Willem J., and Van Wely, Madelon

Published
2018

32. The FOAM study: Is Hysterosalpingo foam sonography (HyFoSy) a cost-effective alternative for hysterosalpingography (HSG) in assessing tubal patency in subfertile women? Study protocol for a randomized controlled trial

Author

CTI Nierkens, Infection & Immunity, Arts-assistenten DV&B, MS VPG/Gynaecologie, Child Health, Circulatory Health, van Rijswijk, Joukje, van Welie, Nienke, Dreyer, Kim, van Hooff, Machiel H.A., de Bruin, Jan Peter, Verhoeve, Harold R., Mol, Femke, Kleiman-Broeze, Kimiko A., Traas, Maaike A.F., Muijsers, Guido J.J.M., Manger, Arentje P., Gianotten, Judith, de Koning, Cornelia H., Koning, Aafke M.H., Bayram, Neriman, van der Ham, David P., Vrouenraets, Francisca P.J.M., Kalafusova, Michaela, van de Laar, Bob I.G., Kaijser, Jeroen, van Oostwaard, Miriam F., Meijer, Wouter J., Broekmans, Frank J.M., Valkenburg, Olivier, van der Voet, Lucy F., van Disseldorp, Jeroen, Lambers, Marieke J., Peters, Henrike E., Lier, Marit C.I., Lambalk, Cornelis B., van Wely, Madelon, Bossuyt, Patrick M.M., Stoker, Jaap, van der Veen, Fulco, Mol, Ben W.J., Mijatovic, Velja, CTI Nierkens, Infection & Immunity, Arts-assistenten DV&B, MS VPG/Gynaecologie, Child Health, Circulatory Health, van Rijswijk, Joukje, van Welie, Nienke, Dreyer, Kim, van Hooff, Machiel H.A., de Bruin, Jan Peter, Verhoeve, Harold R., Mol, Femke, Kleiman-Broeze, Kimiko A., Traas, Maaike A.F., Muijsers, Guido J.J.M., Manger, Arentje P., Gianotten, Judith, de Koning, Cornelia H., Koning, Aafke M.H., Bayram, Neriman, van der Ham, David P., Vrouenraets, Francisca P.J.M., Kalafusova, Michaela, van de Laar, Bob I.G., Kaijser, Jeroen, van Oostwaard, Miriam F., Meijer, Wouter J., Broekmans, Frank J.M., Valkenburg, Olivier, van der Voet, Lucy F., van Disseldorp, Jeroen, Lambers, Marieke J., Peters, Henrike E., Lier, Marit C.I., Lambalk, Cornelis B., van Wely, Madelon, Bossuyt, Patrick M.M., Stoker, Jaap, van der Veen, Fulco, Mol, Ben W.J., and Mijatovic, Velja

Published
2018

33. Association between periconceptional weight loss and maternal and neonatal outcomes in obese infertile women

Author

MS VPG/Gynaecologie, Child Health, Circulatory Health, van Oers, Anne M., Mutsaerts, Meike A.Q., Burggraaff, Jan M., Kuchenbecker, Walter K.H., Perquin, Denise A.M., Koks, Carolien A.M., van Golde, Ron, Kaaijk, Eugenie M., Broekmans, Frank J., De Bruin, Jan Peter, van der Veen, Fulco, Nap, Annemiek W., Gondrie, Ed T.C.M., Mol, Ben W.J., Groen, Henk, Hoek, Annemieke, on behalf of the LIFEstyle study group, MS VPG/Gynaecologie, Child Health, Circulatory Health, van Oers, Anne M., Mutsaerts, Meike A.Q., Burggraaff, Jan M., Kuchenbecker, Walter K.H., Perquin, Denise A.M., Koks, Carolien A.M., van Golde, Ron, Kaaijk, Eugenie M., Broekmans, Frank J., De Bruin, Jan Peter, van der Veen, Fulco, Nap, Annemiek W., Gondrie, Ed T.C.M., Mol, Ben W.J., Groen, Henk, Hoek, Annemieke, and on behalf of the LIFEstyle study group

Published
2018

34. A revised prediction model for natural conception

Author

Bensdorp, Alexandra J, van der Steeg, Jan Willem, Steures, Pieternel, Habbema, J Dik F, Hompes, Peter G A, Bossuyt, Patrick M M, van der Veen, Fulco, Mol, Ben W J, Eijkemans, Marinus J C, and CECERM study group

Subjects
Natural conception, Reproductive Medicine, Prediction model, Journal Article, Subfertility, Prognosis, Developmental Biology
Abstract

One of the aims in reproductive medicine is to differentiate between couples that have favourable chances of conceiving naturally and those that do not. Since the development of the prediction model of Hunault, characteristics of the subfertile population have changed. The objective of this analysis was to assess whether additional predictors can refine the Hunault model and extend its applicability. Consecutive subfertile couples with unexplained and mild male subfertility presenting in fertility clinics were asked to participate in a prospective cohort study. We constructed a multivariable prediction model with the predictors from the Hunault model and new potential predictors. The primary outcome, natural conception leading to an ongoing pregnancy, was observed in 1053 women of the 5184 included couples (20%). All predictors of the Hunault model were selected into the revised model plus an additional seven (woman's body mass index, cycle length, basal FSH levels, tubal status,history of previous pregnancies in the current relationship (ongoing pregnancies after natural conception, fertility treatment or miscarriages), semen volume, and semen morphology. Predictions from the revised model seem to concur better with observed pregnancy rates compared with the Hunault model; c-statistic of 0.71 (95% CI 0.69 to 0.73) compared with 0.59 (95% CI 0.57 to 0.61).

Published
2017

38. Gonadotrophins versus clomifene citrate with or without intrauterine insemination in women with normogonadotropic anovulation and clomifene failure (M-OVIN): a randomised, two-by-two factorial trial

Author

Weiss, Nienke S, primary, Nahuis, Marleen J, additional, Bordewijk, Esmee, additional, Oosterhuis, Jurjen E, additional, Smeenk, Jesper MJ, additional, Hoek, Annemieke, additional, Broekmans, Frank JM, additional, Fleischer, Kathrin, additional, de Bruin, Jan Peter, additional, Kaaijk, Eugenie M, additional, Laven, Joop SE, additional, Hendriks, Dave J, additional, Gerards, Marie H, additional, van Rooij, Ilse AJ, additional, Bourdrez, Petra, additional, Gianotten, Judith, additional, Koks, Carolien, additional, Lambalk, Cornelis B, additional, Hompes, Peter G, additional, van der Veen, Fulco, additional, Mol, Ben Willem J, additional, and van Wely, Madelon, additional

Published
2018
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39. Low dosing of gonadotropins in in vitro fertilization cycles for women with poor ovarian reserve: systematic review and meta-analysis

Author

Youssef, Mohamed Abdel-Fattah, primary, van Wely, Madelon, additional, Mochtar, Monique, additional, Fouda, Usama Mohamed, additional, Eldaly, Ashraf, additional, El Abidin, Eman Zein, additional, Elhalwagy, Ahmed, additional, Mageed Abdallah, Ahmed Abdel, additional, Zaki, Sherif Sameh, additional, Abdel Ghafar, Mohamed Sayed, additional, Mohesen, Mohamed Nagi, additional, and van der Veen, Fulco, additional

Published
2018
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41. Interventions for unexplained subfertility : A systematic review and network meta-analysis

Author

Tjon-Kon-Fat, Raissa I., Wang, Rui, Eijkemans, Marinus J.C., Bossuyt, Patrick M. M., Mol, Ben Willem J., van der Veen, Fulco, Bhattacharya, Siladitya, van Wely, Madelon, Tjon-Kon-Fat, Raissa I., Wang, Rui, Eijkemans, Marinus J.C., Bossuyt, Patrick M. M., Mol, Ben Willem J., van der Veen, Fulco, Bhattacharya, Siladitya, and van Wely, Madelon

Published
2017

42. Interventions for unexplained subfertility: A systematic review and network meta-analysis

Author

UMC Utrecht, Divisieleiding, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Tjon-Kon-Fat, Raissa I., Wang, Rui, Eijkemans, Marinus J.C., Bossuyt, Patrick M. M., Mol, Ben Willem J., van der Veen, Fulco, Bhattacharya, Siladitya, van Wely, Madelon, UMC Utrecht, Divisieleiding, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Tjon-Kon-Fat, Raissa I., Wang, Rui, Eijkemans, Marinus J.C., Bossuyt, Patrick M. M., Mol, Ben Willem J., van der Veen, Fulco, Bhattacharya, Siladitya, and van Wely, Madelon

Published
2017

43. A revised prediction model for natural conception

Author

Biostatistiek Onderzoek, Circulatory Health, Child Health, JC onderzoeksprogramma Methodologie, Infection & Immunity, MS VPG/Gynaecologie, Bensdorp, Alexandra J, van der Steeg, Jan Willem, Steures, Pieternel, Habbema, J Dik F, Hompes, Peter G A, Bossuyt, Patrick M M, van der Veen, Fulco, Mol, Ben W J, Eijkemans, Marinus J C, CECERM study group, Biostatistiek Onderzoek, Circulatory Health, Child Health, JC onderzoeksprogramma Methodologie, Infection & Immunity, MS VPG/Gynaecologie, Bensdorp, Alexandra J, van der Steeg, Jan Willem, Steures, Pieternel, Habbema, J Dik F, Hompes, Peter G A, Bossuyt, Patrick M M, van der Veen, Fulco, Mol, Ben W J, Eijkemans, Marinus J C, and CECERM study group

Published
2017

44. Stimulation of the ovaries in women with breast cancer undergoing fertility preservation: Alternative versus standard stimulation protocols; the study protocol of the STIM-trial

Author

Dahhan, Taghride, Schipper, Izaäk, Louwé, Leoni L.A., Cantineau, Astrid Ep A.E.P., Smeenk, Jesper J.M.J., de Bruin, Jan Peter, Reddy, Nivedita, Kopeika, Y., van der Veen, Fulco, van Wely, Madelon, Linn, Sabine S.C., Balkenende, Eva E.M.E., Goddijn, Mariette, Beerendonk, Catharina C.C.M., Fleischer, Kathrin, Stoop, Dominic, Bosman, Anna-Maria, Lambalk, Cornelis C.B., Schats, Roel, van Golde, Ron R.J.T., Dahhan, Taghride, Schipper, Izaäk, Louwé, Leoni L.A., Cantineau, Astrid Ep A.E.P., Smeenk, Jesper J.M.J., de Bruin, Jan Peter, Reddy, Nivedita, Kopeika, Y., van der Veen, Fulco, van Wely, Madelon, Linn, Sabine S.C., Balkenende, Eva E.M.E., Goddijn, Mariette, Beerendonk, Catharina C.C.M., Fleischer, Kathrin, Stoop, Dominic, Bosman, Anna-Maria, Lambalk, Cornelis C.B., Schats, Roel, and van Golde, Ron R.J.T.

Abstract

Background Chemotherapy for breast cancer may have a negative impact on reproductive function due to gonadotoxicity. Fertility preservation via banking of oocytes or embryos after ovarian stimulation with FSH can increase the likelihood of a future live birth. It has been hypothesized that elevated serum estrogen levels during ovarian stimulation may induce breast tumour growth. This has led to the use of alternative stimulation protocols with addition of tamoxifen or letrozole. The effectiveness of these stimulation protocols in terms of oocyte yield is unknown. Methods/design Randomized open-label trial comparing ovarian stimulation plus tamoxifen and ovarian stimulation plus letrozole with standard ovarian stimulation in the course of fertility preservation. The study population consists of women with breast cancer who opt for banking of oocytes or embryos, aged 18–43 years at randomisation. Primary outcome is the number of oocytes retrieved at follicle aspiration. Secondary outcomes are number of mature oocytes retrieved, number of oocytes or embryos banked and peak E2 levels during ovarian stimulation. Discussion Concerning the lack of evidence on which stimulation protocol should be used in women with breast cancer and the growing demand for fertility preservation, there is an urgent need to undertake this study. By performing this study, we will be able to closely monitor the effects of various stimulation protocols in women with breast cancer and pave the way for long term follow up on the safety of this procedure in terms of breast cancer prognosis. Trial Registration: NTR4108., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2017

47. A revised prediction model for natural conception

Author

Bensdorp, Alexandra J., primary, van der Steeg, Jan Willem, additional, Steures, Pieternel, additional, Habbema, J. Dik F., additional, Hompes, Peter G.A., additional, Bossuyt, Patrick M.M., additional, van der Veen, Fulco, additional, Mol, Ben W.J., additional, Eijkemans, Marinus J.C., additional, van Kasteren, Y.M., additional, van der Heijden, P.F.M., additional, Schöls, W.A., additional, Mochtar, M.H., additional, Lips, G.L.M., additional, Dawson, J., additional, Verhoeve, H.R., additional, Milosavljevic, S., additional, Hompes, P.G.A., additional, van Dam, L.J., additional, Sluijmer, A.V., additional, Bobeck, H.E., additional, Bernardus, R.E., additional, Vermeer, M.C.S., additional, Dörr, J.P., additional, van der Linden, P.J.Q., additional, Roelofs, H.J.M., additional, Burggraaff, J.M., additional, Oosterhuis, G.J.E., additional, Schouwink, M.H., additional, Bouckaert, P.X.J.M., additional, Delemarre, F.M.C., additional, Hamilton, C.J.C.M., additional, van Hoven, M., additional, Emanuel, M.H., additional, Renckens, C.N.M., additional, Land, J.A., additional, Schagen-Van Leeuwen, J.H., additional, Kremer, J.A.M., additional, van Katwijk, C., additional, van Hooff, M.H.A., additional, Van Dessel, H.J.H.M., additional, Broekmans, F.J.M., additional, Ruis, H.J.L.A., additional, Koks, C.A.M., additional, Bourdrez, P., additional, Riedijk, W.W.J., additional, and Cohlen, B.J., additional

Published
2017
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