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Donor sperm treatment: the role of semen parameters in intracervical insemination, a retrospective cohort study.

Authors :
Kop, Petronella
van Wely, Madelon
de Melker, Annemieke
van der Veen, Fulco
Mochtar, Monique
Source :
Human Fertility; Dec2023, Vol. 26 Issue 5, p964-970, 7p
Publication Year :
2023

Abstract

Donor sperm treatment is advised to be performed with frozen-thawed donor semen. A disadvantage of frozen-thawed semen is lower pregnancy rates compared to inseminations with fresh semen. Semen parameters affect ongoing pregnancy rates in intracervical inseminations with frozen-thawed donor semen. In an attempt to translate this into clinical relevance, cohort studies have tried to find cut-off values for semen parameters after thawing for intracervical insemination, but these studies assessed only one semen parameter per study, thereby overlooking the intricate interplay between all semen parameters. We performed a retrospective cohort study and tried to calculate thresholds for all semen parameters that lead to the best possible ongoing pregnancy rates in intracervical insemination with frozen-thawed donor semen. Between April 1999 and December 2015, data from 1,186 women who underwent 7,103 cycles of intracervical insemination with donor semen from 129 sperm donors were available for analysis. Our results showed that total motility and total motile count (TMC) after thawing were associated with ongoing pregnancy rate. The best possible ongoing pregnancy chances after intracervical insemination were obtained at a total motility of ≥20% and a total motile count (TMC) of ≥8 × 10<superscript>6</superscript> after thawing. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14647273
Volume :
26
Issue :
5
Database :
Complementary Index
Journal :
Human Fertility
Publication Type :
Academic Journal
Accession number :
174421270
Full Text :
https://doi.org/10.1080/14647273.2022.2032407