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Your search keyword '"Zorro, M"' showing total 6 results
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6 results on '"Zorro, M"'

1. Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses

Author

Bakker, O.B., Aguirre-Gamboa, R., Sanna, S., Oosting, M., Smeekens, S.P., Jaeger, M., Zorro, M., Vosa, U., Withoff, S., Netea-Maier, R.T., Koenen, H.J.P.M., Joosten, I., Xavier, R.J., Franke, L., Joosten, L.A.B., Kumar, V., Wijmenga, C., Netea, M.G., Li, Y., Bakker, O.B., Aguirre-Gamboa, R., Sanna, S., Oosting, M., Smeekens, S.P., Jaeger, M., Zorro, M., Vosa, U., Withoff, S., Netea-Maier, R.T., Koenen, H.J.P.M., Joosten, I., Xavier, R.J., Franke, L., Joosten, L.A.B., Kumar, V., Wijmenga, C., Netea, M.G., and Li, Y.

Abstract

Contains fulltext : 193382.pdf (publisher's version ) (Closed access), The immune response to pathogens varies substantially among people. Whereas both genetic and nongenetic factors contribute to interperson variation, their relative contributions and potential predictive power have remained largely unknown. By systematically correlating host factors in 534 healthy volunteers, including baseline immunological parameters and molecular profiles (genome, metabolome and gut microbiome), with cytokine production after stimulation with 20 pathogens, we identified distinct patterns of co-regulation. Among the 91 different cytokine-stimulus pairs, 11 categories of host factors together explained up to 67% of interindividual variation in cytokine production induced by stimulation. A computational model based on genetic data predicted the genetic component of stimulus-induced cytokine production (correlation 0.28-0.89), and nongenetic factors influenced cytokine production as well.

Published
2018

2. Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits

Author

Aguirre-Gamboa, R., Joosten, I., Urbano, P.C., Molen, R.G. van der, Rijssen, E. van, Cranenbroek, B. van, Oosting, M., Smeekens, S., Jaeger, M., Zorro, M., Withoff, S., Herwaarden, A.E. van, Sweep, C.G.J., Netea, R.T., Swertz, M.A., Franke, L., Xavier, R.J., Joosten, L.A.B., Netea, M.G., Wijmenga, C., Kumar, V., Li, Y., Koenen, H.J.P.M., Aguirre-Gamboa, R., Joosten, I., Urbano, P.C., Molen, R.G. van der, Rijssen, E. van, Cranenbroek, B. van, Oosting, M., Smeekens, S., Jaeger, M., Zorro, M., Withoff, S., Herwaarden, A.E. van, Sweep, C.G.J., Netea, R.T., Swertz, M.A., Franke, L., Xavier, R.J., Joosten, L.A.B., Netea, M.G., Wijmenga, C., Kumar, V., Li, Y., and Koenen, H.J.P.M.

Abstract

Contains fulltext : 172315.pdf (publisher's version ) (Open Access), Effective immunity requires a complex network of cellular and humoral components that interact with each other and are influenced by different environmental and host factors. We used a systems biology approach to comprehensively assess the impact of environmental and genetic factors on immune cell populations in peripheral blood, including associations with immunoglobulin concentrations, from approximately 500 healthy volunteers from the Human Functional Genomics Project. Genetic heritability estimation showed that variations in T cell numbers are more strongly driven by genetic factors, while B cell counts are more environmentally influenced. Quantitative trait loci (QTL) mapping identified eight independent genomic loci associated with leukocyte count variation, including four associations with T and B cell subtypes. The QTLs identified were enriched among genome-wide association study (GWAS) SNPs reported to increase susceptibility to immune-mediated diseases. Our systems approach provides insights into cellular and humoral immune trait variability in humans.

Published
2016

3. Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs

Author

Ricano-Ponce, I, Zhernakova, DV, Deelen, P, Luo, O, Li, XW, Isaacs, Aaron, Karjalainen, J, Di Tommaso, J, Borek, Z A, Zorro, M M, Gutierrez-Achury, J, Uitterlinden, André, Hofman, Bert, van Meurs, Joyce, Netea, MG, Jonkers, IH, Withoff, S, Duijn, Cornelia, Li, Y, Ruan, Y J, Franke, L, Wijmenga, C, Kumar, V, Ricano-Ponce, I, Zhernakova, DV, Deelen, P, Luo, O, Li, XW, Isaacs, Aaron, Karjalainen, J, Di Tommaso, J, Borek, Z A, Zorro, M M, Gutierrez-Achury, J, Uitterlinden, André, Hofman, Bert, van Meurs, Joyce, Netea, MG, Jonkers, IH, Withoff, S, Duijn, Cornelia, Li, Y, Ruan, Y J, Franke, L, Wijmenga, C, and Kumar, V

Published
2016

4. Tissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytes

Author

Rinse K. Weersma, Bana Jabri, Raul Aguirre-Gamboa, Sebo Withoff, Toufic Mayassi, Shixian Hu, Cezary Ciszewski, Yang Li, Maria M. Zorro, Iris Jonkers, Donatella Barisani, Cisca Wijmenga, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Molecular Neuroscience and Ageing Research (MOLAR), Department of Health and Life Sciences, Zorro, M, Aguirre-Gamboa, R, Mayassi, T, Ciszewski, C, Barisani, D, Hu, S, Weersma, R, Withoff, S, Li, Y, Wijmenga, C, Jabri, B, Jonkers, I, and CiiM, Zentrum für individualisierte Infektionsmedizin, Feodor-Lynen-Str.7, 30625 Hannover.

Subjects
0301 basic medicine, medicine.medical_treatment, Autoimmunity, Intraepithelial lymphocytes, DISEASE, Transcriptome, Tissue-resident lymphocytes, 0302 clinical medicine, Autoimmune disease, IL-21, Immunology and Allergy, Cytotoxic T cell, Alarmins, Intestinal Mucosa, Promoter Regions, Genetic, Interleukin-15, ARCHITECTURE, Interleukin, ASSOCIATION, 3. Good health, Cell biology, Cytokine, IL-15, Interleukin 15, Cytokines, EXPRESSION, SUSCEPTIBILITY LOCI, Immunology, EFFECTOR CTL, GENETIC RISK, IMMUNITY, Biology, IFN beta, Article, Tissue-resident lymphocyte, 03 medical and health sciences, medicine, Humans, Epigenetics, 030203 arthritis & rheumatology, Cytotoxic T lymphocyte, Intraepithelial lymphocyte, IDENTIFICATION, Gene Expression Profiling, medicine.disease, Inflammatory Bowel Diseases, Cytotoxic T lymphocytes, Celiac Disease, 030104 developmental biology, Gene Expression Regulation, CELLS, IFNβ, T-Lymphocytes, Cytotoxic
Abstract

The respective effects of tissue alarmins interleukin (IL)-15 and interferon beta (IFNβ), and IL-21 produced by T cells on the reprogramming of cytotoxic T lymphocytes (CTLs) that cause tissue destruction in celiac disease is poorly understood. Transcriptomic and epigenetic profiling of primary intestinal CTLs showed massive and distinct temporal transcriptional changes in response to tissue alarmins, while the impact of IL-21 was limited. Only anti-viral pathways were induced in response to all the three stimuli, albeit with differences in dynamics and strength. Moreover, changes in gene expression were primarily independent of changes in H3K27ac, suggesting that other regulatory mechanisms drive the robust transcriptional response. Finally, we found that IL-15/IFNβ/IL-21 transcriptional signatures could be linked to transcriptional alterations in risk loci for complex immune diseases. Together these results provide new insights into molecular mechanisms that fuel the activation of CTLs under conditions that emulate the inflammatory environment in patients with autoimmune diseases., Highlights • We report the epigenetic and transcriptomic response of IE-CTLs to tissue-derived alarmins and adaptive cytokine. • IL-15 and IFNβ induce massive and distinct transcriptional changes in IE-CTLs, while the impact of IL-21 was limited. • Genes associated with immune-mediated intestinal diseases are enriched in genes responding to IL-15, IFNβ and IL-21 in IE-CTLs.

Published
2019

5. Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses.

Author

Bakker OB, Aguirre-Gamboa R, Sanna S, Oosting M, Smeekens SP, Jaeger M, Zorro M, Võsa U, Withoff S, Netea-Maier RT, Koenen HJPM, Joosten I, Xavier RJ, Franke L, Joosten LAB, Kumar V, Wijmenga C, Netea MG, and Li Y

Subjects
Adolescent, Adult, Aged, Autoimmune Diseases genetics, Autoimmune Diseases immunology, Cytokines genetics, Female, Gene Expression Profiling, Genomics, Humans, Male, Metabolomics, Metagenomics, Middle Aged, Phenotype, Systems Biology, Young Adult, Cytokines biosynthesis
Abstract

The immune response to pathogens varies substantially among people. Whereas both genetic and nongenetic factors contribute to interperson variation, their relative contributions and potential predictive power have remained largely unknown. By systematically correlating host factors in 534 healthy volunteers, including baseline immunological parameters and molecular profiles (genome, metabolome and gut microbiome), with cytokine production after stimulation with 20 pathogens, we identified distinct patterns of co-regulation. Among the 91 different cytokine-stimulus pairs, 11 categories of host factors together explained up to 67% of interindividual variation in cytokine production induced by stimulation. A computational model based on genetic data predicted the genetic component of stimulus-induced cytokine production (correlation 0.28-0.89), and nongenetic factors influenced cytokine production as well.

Published
2018
Full Text
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6. Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits.

Author

Aguirre-Gamboa R, Joosten I, Urbano PCM, van der Molen RG, van Rijssen E, van Cranenbroek B, Oosting M, Smeekens S, Jaeger M, Zorro M, Withoff S, van Herwaarden AE, Sweep FCGJ, Netea RT, Swertz MA, Franke L, Xavier RJ, Joosten LAB, Netea MG, Wijmenga C, Kumar V, Li Y, and Koenen HJPM

Subjects
Adolescent, Adult, Age Factors, Aged, Chromosomes, Human genetics, Cohort Studies, Cyclic Nucleotide Phosphodiesterases, Type 4 genetics, Female, Humans, Immunoglobulins metabolism, Lymphocyte Count, Lymphocyte Subsets metabolism, Male, Middle Aged, Myosin Type I genetics, Netherlands, Quantitative Trait Loci genetics, Seasons, Young Adult, B-Lymphocytes immunology, Environment, Immunity, Cellular genetics, Immunity, Humoral genetics, T-Lymphocytes immunology
Abstract

Effective immunity requires a complex network of cellular and humoral components that interact with each other and are influenced by different environmental and host factors. We used a systems biology approach to comprehensively assess the impact of environmental and genetic factors on immune cell populations in peripheral blood, including associations with immunoglobulin concentrations, from ∼500 healthy volunteers from the Human Functional Genomics Project. Genetic heritability estimation showed that variations in T cell numbers are more strongly driven by genetic factors, while B cell counts are more environmentally influenced. Quantitative trait loci (QTL) mapping identified eight independent genomic loci associated with leukocyte count variation, including four associations with T and B cell subtypes. The QTLs identified were enriched among genome-wide association study (GWAS) SNPs reported to increase susceptibility to immune-mediated diseases. Our systems approach provides insights into cellular and humoral immune trait variability in humans., (Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2016
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