224 results on '"Zoeller, R. Thomas"'
Search Results
2. Neuroendocrine effects of polychlorinated biphenyls (PCBs)
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Gore, Andrea C., primary, Zoeller, R. Thomas, additional, and Currás-Collazo, Margarita, additional
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- 2023
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- View/download PDF
3. Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort
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Hall, Meaghan, Lanphear, Bruce, Chevrier, Jonathan, Hornung, Rick, Green, Rivka, Goodman, Carly, Ayotte, Pierre, Martinez-Mier, Esperanza Angeles, Zoeller, R. Thomas, and Till, Christine
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- 2023
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- View/download PDF
4. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification
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La Merrill, Michele A, Vandenberg, Laura N, Smith, Martyn T, Goodson, William, Browne, Patience, Patisaul, Heather B, Guyton, Kathryn Z, Kortenkamp, Andreas, Cogliano, Vincent J, Woodruff, Tracey J, Rieswijk, Linda, Sone, Hideko, Korach, Kenneth S, Gore, Andrea C, Zeise, Lauren, and Zoeller, R Thomas
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Biomedical and Clinical Sciences ,Clinical Sciences ,Estrogen ,Endocrine Disruptors ,Cancer ,Animals ,Consensus ,Environmental Exposure ,Environmental Pollutants ,Humans ,Receptors ,Corticotropin ,Endocrinology & Metabolism ,Clinical sciences - Abstract
Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Inspired by work to improve hazard identification of carcinogens using key characteristics (KCs), we have developed ten KCs of EDCs based on our knowledge of hormone actions and EDC effects. In this Expert Consensus Statement, we describe the logic by which these KCs are identified and the assays that could be used to assess several of these KCs. We reflect on how these ten KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs, and we use diethylstilbestrol, bisphenol A and perchlorate as examples to illustrate this approach.
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- 2020
5. Letter to the editor regarding Hall et al. (2023): Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort
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Hall, Meaghan, primary, Lanphear, Bruce, additional, Chevrier, Jonathan, additional, Hornung, Rick, additional, Green, Rivka, additional, Goodman, Carly, additional, Ayotte, Pierre, additional, Martinez-Mier, Esperanza Angeles, additional, Zoeller, R. Thomas, additional, and Till, Christine, additional
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- 2024
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- View/download PDF
6. The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA)
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vom Saal, Frederick S., primary, Antoniou, Michael, additional, Belcher, Scott M., additional, Bergman, Ake, additional, Bhandari, Ramji K., additional, Birnbaum, Linda S., additional, Cohen, Aly, additional, Collins, Terrence J., additional, Demeneix, Barbara, additional, Fine, Anne Marie, additional, Flaws, Jodi A., additional, Gayrard, Veronique, additional, Goodson, William H., additional, Gore, Andrea C., additional, Heindel, Jerrold J., additional, Hunt, Patricia A., additional, Iguchi, Taisen, additional, Kassotis, Christopher D., additional, Kortenkamp, Andreas, additional, Mesnage, Robin, additional, Muncke, Jane, additional, Myers, John Peterson, additional, Nadal, Angel, additional, Newbold, Retha R., additional, Padmanabhan, Vasantha, additional, Palanza, Paola, additional, Palma, Zandra, additional, Parmigiani, Stefano, additional, Patrick, Lyn, additional, Prins, Gail S., additional, Rosenfeld, Cheryl S., additional, Skakkebaek, Niels E., additional, Sonnenschein, Carlos, additional, Soto, Ana M., additional, Swan, Shanna H., additional, Taylor, Julia A., additional, Toutain, Pierre-Louis, additional, von Hippel, Frank A., additional, Welshons, Wade V., additional, Zalko, Daniel, additional, and Zoeller, R. Thomas, additional
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- 2024
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- View/download PDF
7. Comparative Analyses of the 12 Most Abundant PCB Congeners Detected in Human Maternal Serum for Activity at the Thyroid Hormone Receptor and Ryanodine Receptor
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Sethi, Sunjay, Morgan, Rhianna K, Feng, Wei, Lin, Yanping, Li, Xueshu, Luna, Corey, Koch, Madison, Bansal, Ruby, Duffel, Michael W, Puschner, Birgit, Zoeller, R Thomas, Lehmler, Hans-Joachim, Pessah, Isaac N, and Lein, Pamela J
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Biomedical and Clinical Sciences ,Environmental Sciences ,Pollution and Contamination ,Pediatric ,Endocrine Disruptors ,Neurosciences ,Brain Disorders ,Intellectual and Developmental Disabilities (IDD) ,Child ,Environmental Pollutants ,Female ,Humans ,Polychlorinated Biphenyls ,Pregnancy ,Receptors ,Thyroid Hormone ,Ryanodine Receptor Calcium Release Channel ,Serum - Abstract
Polychlorinated biphenyls (PCBs) pose significant risk to the developing human brain; however, mechanisms of PCB developmental neurotoxicity (DNT) remain controversial. Two widely posited mechanisms are tested here using PCBs identified in pregnant women in the MARBLES cohort who are at increased risk for having a child with a neurodevelopmental disorder (NDD). As determined by gas chromatography-triple quadruple mass spectrometry, the mean PCB level in maternal serum was 2.22 ng/mL. The 12 most abundant PCBs were tested singly and as a mixture mimicking the congener profile in maternal serum for activity at the thyroid hormone receptor (THR) and ryanodine receptor (RyR). Neither the mixture nor the individual congeners (2 fM to 2 μM) exhibited agonistic or antagonistic activity in a THR reporter cell line. However, as determined by equilibrium binding of [3H]ryanodine to RyR1-enriched microsomes, the mixture and the individual congeners (50 nM to 50 μM) increased RyR activity by 2.4-19.2-fold. 4-Hydroxy (OH) and 4-sulfate metabolites of PCBs 11 and 52 had no TH activity; but 4-OH PCB 52 had higher potency than the parent congener toward RyR. These data support evidence implicating RyRs as targets in environmentally triggered NDDs and suggest that PCB effects on the THR are not a predominant mechanism driving PCB DNT. These findings provide scientific rationale regarding a point of departure for quantitative risk assessment of PCB DNT, and identify in vitro assays for screening other environmental pollutants for DNT potential.
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- 2019
8. Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDE metabolites (OH-PBDEs) in maternal and fetal tissues, and associations with fetal cytochrome P450 gene expression
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Zota, Ami R, Mitro, Susanna D, Robinson, Joshua F, Hamilton, Emily G, Park, June-Soo, Parry, Emily, Zoeller, R Thomas, and Woodruff, Tracey J
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Environmental Sciences ,Pollution and Contamination ,Clinical Research ,Pediatric ,Digestive Diseases ,Reproductive health and childbirth ,Good Health and Well Being ,Cytochrome P-450 Enzyme System ,Female ,Fetus ,Halogenated Diphenyl Ethers ,Humans ,Hydroxylation ,Liver ,Maternal Exposure ,Pregnancy ,Brominated flame retardants ,Fetal metabolism ,Prenatal exposures ,OH-PBDEs ,Endocrine disrupters ,Cytochrome P-450 enzymes ,Placenta transport ,Organohalogen chemicals - Abstract
BackgroundHuman fetal exposures to polybrominated diphenyl ethers (PBDEs) and their metabolites (OH-PBDEs) are unique from adults, and in combination with a different metabolic profile, may make fetal development more sensitive to adverse health outcomes from these exposures. However, we lack data to characterize human fetal PBDE exposures and the metabolic factors that can influence these exposures.ObjectiveWe examined differences between 2nd trimester maternal and fetal exposures to PBDEs and OH-PBDEs. We also characterized fetal cytochrome P450 (CYP) mRNA expression and its associations with PBDE exposures.MethodsWe collected paired samples of maternal serum and fetal liver (n=86) with a subset having matched placenta (n=50). We measured PBDEs, OH-PBDEs, and mRNA expression of CYP genes (e.g. CYP1A1, -2E1, -2J2, -2C9) in all samples. As a sensitivity analysis, we measured PBDEs and OH-PBDEs in umbilical cord serum from a subset (n=22).ResultsBDE-47 was detected in ≥96% of all tissues. Unadjusted ∑PBDEs concentrations were highest in fetal liver (geometric mean (GM)=0.72ng/g), whereas lipid-adjusted concentrations were highest in cord serum (111.12ng/g lipid). In both cases, fetal concentrations were approximately two times higher than maternal serum levels (GM=0.33ng/g or 48.75ng/g lipid). ΣOH-PBDEs were highest in maternal and cord sera and 20-200 times lower than PBDE concentrations. In regression models, maternal BDE-47 explained more of the model variance of liver than of placenta BDE-47 concentrations (adjusted R2=0.79 vs 0.48, respectively). In adjusted logistic regression models, ∑PBDEs were positively associated with expression of CYP2E1 and -2J2 (placenta), and -1A1 (liver) (p
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- 2018
9. Correction to: Parma consensus statement on metabolic disruptors.
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Heindel, Jerrold J, Vom Saal, Frederick S, Blumberg, Bruce, Bovolin, Patrizia, Calamandrei, Gemma, Ceresini, Graziano, Cohn, Barbara A, Fabbri, Elena, Gioiosa, Laura, Kassotis, Christopher, Legler, Juliette, La Merrill, Michele, Rizzi, Laura, Machtinger, Ronit, Mantovani, Alberto, Mendez, Michelle A, Montanini, Luisa, Molteni, Laura, Nagel, Susan C, Parmigiani, Stefano, Panzica, Giancarlo, Paterlini, Silvia, Pomatto, Valentina, Ruzzin, Jérôme, Sartor, Giorgio, Schug, Thaddeus T, Street, Maria E, Suvorov, Alexander, Volpi, Riccardo, Zoeller, R Thomas, and Palanza, Paola
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Toxicology ,Public Health and Health Services - Abstract
CorrectionAfter publication of the article [1], it has been brought to our attention that the thirteenth author of this article has had their name spelt incorrectly. In the original article the spelling "Laura Rizzir" was used. In fact the correct spelling should be "Laura Rizzi".
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- 2017
10. Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies
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Heindel, Jerrold J., Belcher, Scott, Flaws, Jodi A., Prins, Gail S., Ho, Shuk-Mei, Mao, Jiude, Patisaul, Heather B., Ricke, William, Rosenfeld, Cheryl S., Soto, Ana M., vom Saal, Frederick S., and Zoeller, R. Thomas
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- 2020
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11. Project TENDR: Targeting Environmental Neuro-Developmental Risks The TENDR Consensus Statement
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Bennett, Deborah, Bellinger, David C, Birnbaum, Linda S, Bradman, Asa, Chen, Aimin, Cory-Slechta, Deborah A, Engel, Stephanie M, Fallin, M Daniele, Halladay, Alycia, Hauser, Russ, Hertz-Picciotto, Irva, Kwiatkowski, Carol F, Lanphear, Bruce P, Marquez, Emily, Marty, Melanie, McPartland, Jennifer, Newschaffer, Craig J, Payne-Sturges, Devon, Patisaul, Heather B, Perera, Frederica P, Ritz, Beate, Sass, Jennifer, Schantz, Susan L, Webster, Thomas F, Whyatt, Robin M, Woodruff, Tracey J, Zoeller, R Thomas, Anderko, Laura, Campbell, Carla, Conry, Jeanne A, DeNicola, Nathaniel, Gould, Robert M, Hirtz, Deborah, Huffling, Katie, Landrigan, Philip J, Lavin, Arthur, Miller, Mark, Mitchell, Mark A, Rubin, Leslie, Schettler, Ted, Tran, Ho Luong, Acosta, Annie, Brody, Charlotte, Miller, Elise, Miller, Pamela, Swanson, Maureen, and Witherspoon, Nsedu Obot
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Biomedical and Clinical Sciences ,Prevention ,Pediatric ,Clinical Research ,Pediatric Research Initiative ,Autism ,Neurosciences ,Brain Disorders ,Intellectual and Developmental Disabilities (IDD) ,Mental Health ,Behavioral and Social Science ,Aetiology ,2.2 Factors relating to the physical environment ,Mental health ,Child ,Developmental Disabilities ,Environmental Exposure ,Environmental Health ,Humans ,Neurodevelopmental Disorders ,Public Health ,Risk Assessment ,United States ,American College of Obstetricians and Gynecologists ,Child Neurology Society ,Endocrine Society ,International Neurotoxicology Association ,International Society for Children’s Health and the Environment ,International Society for Environmental Epidemiology ,National Council of Asian Pacific Islander Physicians ,National Hispanic Medical Association ,National Medical Association ,Environmental Sciences ,Medical and Health Sciences ,Toxicology ,Biomedical and clinical sciences ,Environmental sciences ,Health sciences - Abstract
Summary: Children in America today are at an unacceptably high risk of developing neurodevelopmental disorders that affect the brain and nervous system including autism, attention deficit hyperactivity disorder, intellectual disabilities, and other learning and behavioral disabilities. These are complex disorders with multiple causes—genetic, social, and environmental. The contribution of toxic chemicals to these disorders can be prevented. Approach: Leading scientific and medical experts, along with children’s health advocates, came together in 2015 under the auspices of Project TENDR: Targeting Environmental Neuro-Developmental Risks to issue a call to action to reduce widespread exposures to chemicals that interfere with fetal and children’s brain development. Based on the available scientific evidence, the TENDR authors have identified prime examples of toxic chemicals and pollutants that increase children’s risks for neurodevelopmental disorders. These include chemicals that are used extensively in consumer products and that have become widespread in the environment. Some are chemicals to which children and pregnant women are regularly exposed, and they are detected in the bodies of virtually all Americans in national surveys conducted by the U.S. Centers for Disease Control and Prevention. The vast majority of chemicals in industrial and consumer products undergo almost no testing for developmental neurotoxicity or other health effects. Conclusion: Based on these findings, we assert that the current system in the United States for evaluating scientific evidence and making health-based decisions about environmental chemicals is fundamentally broken. To help reduce the unacceptably high prevalence of neurodevelopmental disorders in our children, we must eliminate or significantly reduce exposures to chemicals that contribute to these conditions. We must adopt a new framework for assessing chemicals that have the potential to disrupt brain development and prevent the use of those that may pose a risk. This consensus statement lays the foundation for developing recommendations to monitor, assess, and reduce exposures to neurotoxic chemicals. These measures are urgently needed if we are to protect healthy brain development so that current and future generations can reach their fullest potential.
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- 2016
12. Manufacturing doubt about endocrine disrupter science--A rebuttal of industry-sponsored critical comments on the UNEP/WHO report "State of the Science of Endocrine Disrupting Chemicals 2012".
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Bergman, Åke, Becher, Georg, Blumberg, Bruce, Bjerregaard, Poul, Bornman, Riana, Brandt, Ingvar, Casey, Stephanie C, Frouin, Heloise, Giudice, Linda C, Heindel, Jerrold J, Iguchi, Taisen, Jobling, Susan, Kidd, Karen A, Kortenkamp, Andreas, Lind, P Monica, Muir, Derek, Ochieng, Roseline, Ropstad, Erik, Ross, Peter S, Skakkebaek, Niels Erik, Toppari, Jorma, Vandenberg, Laura N, Woodruff, Tracey J, and Zoeller, R Thomas
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Animals ,Humans ,Endocrine Disruptors ,EDCs ,Endocrine disruption ,Endocrine disruptors ,Pharmacology and Pharmaceutical Sciences ,Toxicology - Abstract
We present a detailed response to the critique of "State of the Science of Endocrine Disrupting Chemicals 2012" (UNEP/WHO, 2013) by financial stakeholders, authored by Lamb et al. (2014). Lamb et al.'s claim that UNEP/WHO (2013) does not provide a balanced perspective on endocrine disruption is based on incomplete and misleading quoting of the report through omission of qualifying statements and inaccurate description of study objectives, results and conclusions. Lamb et al. define extremely narrow standards for synthesizing evidence which are then used to dismiss the UNEP/WHO 2013 report as flawed. We show that Lamb et al. misuse conceptual frameworks for assessing causality, especially the Bradford-Hill criteria, by ignoring the fundamental problems that exist with inferring causality from empirical observations. We conclude that Lamb et al.'s attempt of deconstructing the UNEP/WHO (2013) report is not particularly erudite and that their critique is not intended to be convincing to the scientific community, but to confuse the scientific data. Consequently, it promotes misinterpretation of the UNEP/WHO (2013) report by non-specialists, bureaucrats, politicians and other decision makers not intimately familiar with the topic of endocrine disruption and therefore susceptible to false generalizations of bias and subjectivity.
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- 2015
13. Parma consensus statement on metabolic disruptors
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Heindel, Jerrold J, vom Saal, Frederick S, Blumberg, Bruce, Bovolin, Patrizia, Calamandrei, Gemma, Ceresini, Graziano, Cohn, Barbara A, Fabbri, Elena, Gioiosa, Laura, Kassotis, Christopher, Legler, Juliette, La Merrill, Michele, Rizzir, Laura, Machtinger, Ronit, Mantovani, Alberto, Mendez, Michelle A, Montanini, Luisa, Molteni, Laura, Nagel, Susan C, Parmigiani, Stefano, Panzica, Giancarlo, Paterlini, Silvia, Pomatto, Valentina, Ruzzin, Jérôme, Sartor, Giorgio, Schug, Thaddeus T, Street, Maria E, Suvorov, Alexander, Volpi, Riccardo, Zoeller, R Thomas, and Palanza, Paola
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Epidemiology ,Public Health ,Health Sciences ,Obesity ,Nutrition ,2.1 Biological and endogenous factors ,Aetiology ,Metabolic and endocrine ,Congresses as Topic ,Consensus Development Conferences as Topic ,Diabetes Mellitus ,Environmental Exposure ,Environmental Pollutants ,Hazardous Substances ,Humans ,Italy ,Metabolic Syndrome ,Metabolic disruptor ,Obesogen ,Diabetes ,Metabolic syndrome ,Developmental Programming ,Public Health and Health Services ,Toxicology ,Public health - Abstract
A multidisciplinary group of experts gathered in Parma Italy for a workshop hosted by the University of Parma, May 16-18, 2014 to address concerns about the potential relationship between environmental metabolic disrupting chemicals, obesity and related metabolic disorders. The objectives of the workshop were to: 1. Review findings related to the role of environmental chemicals, referred to as "metabolic disruptors", in obesity and metabolic syndrome with special attention to recent discoveries from animal model and epidemiology studies; 2. Identify conclusions that could be drawn with confidence from existing animal and human data; 3. Develop predictions based on current data; and 4. Identify critical knowledge gaps and areas of uncertainty. The consensus statements are intended to aid in expanding understanding of the role of metabolic disruptors in the obesity and metabolic disease epidemics, to move the field forward by assessing the current state of the science and to identify research needs on the role of environmental chemical exposures in these diseases. We propose broadening the definition of obesogens to that of metabolic disruptors, to encompass chemicals that play a role in altered susceptibility to obesity, diabetes and related metabolic disorders including metabolic syndrome.
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- 2015
14. Endocrine disrupting chemicals and thyroid hormone action
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Zoeller, R. Thomas, primary
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- 2021
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15. European Medicines Agency Conflicts With the European Food Safety Authority (EFSA) on Bisphenol A Regulation
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Zoeller, R Thomas, primary, Birnbaum, Linda S, additional, Collins, Terrence J, additional, Heindel, Jerrold, additional, Hunt, Patricia A, additional, Iguchi, Taisen, additional, Kortenkamp, Andreas, additional, Myers, John Peterson, additional, vom Saal, Frederick S, additional, Sonnenschein, Carlos, additional, and Soto, Ana M, additional
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- 2023
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16. Endocrine-Disrupting Chemicals: Brain–Behavior Effects on Thyroid and Sexual Differentiation
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Zoeller, R. Thomas, primary and vom Saal, Frederick S., additional
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- 2020
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17. Effects of Sample Handling and Analytical Procedures on Thyroid Hormone Concentrations in Pregnant Women’s Plasma
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Villanger, Gro Dehli, Learner, Emily, Longnecker, Matthew P., Ask, Helga, Aase, Heidi, Zoeller, R. Thomas, Knudsen, Gun P., Reichborn-Kjennerud, Ted, Zeiner, Pål, and Engel, Stephanie M.
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- 2017
18. Impacts of food contact chemicals on human health: a consensus statement
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Muncke, Jane, Andersson, Anna-Maria, Backhaus, Thomas, Boucher, Justin M., Carney Almroth, Bethanie, Castillo Castillo, Arturo, Chevrier, Jonathan, Demeneix, Barbara A., Emmanuel, Jorge A., Fini, Jean-Baptiste, Gee, David, Geueke, Birgit, Groh, Ksenia, Heindel, Jerrold J., Houlihan, Jane, Kassotis, Christopher D., Kwiatkowski, Carol F., Lefferts, Lisa Y., Maffini, Maricel V., Martin, Olwenn V., Myers, John Peterson, Nadal, Angel, Nerin, Cristina, Pelch, Katherine E., Fernández, Seth Rojello, Sargis, Robert M., Soto, Ana M., Trasande, Leonardo, Vandenberg, Laura N., Wagner, Martin, Wu, Changqing, Zoeller, R. Thomas, and Scheringer, Martin
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- 2020
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19. Application of In Situ Hybridization to the Study of Rhythmic Neural Systems
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Albers, H. Elliott, primary, Zoeller, R. Thomas, additional, and Huhman, Kim L., additional
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- 2019
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20. A vision for safer food contact materials: public health concerns as drivers for improved testing
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Muncke, Jane, Andersson, Anna-Maria, Backhaus, Thomas, Belcher, Scott M., Boucher, Justin M., Carney Almroth, Bethanie, Collins, Terrence J., Geueke, Birgit, Groh, Ksenia J., Heindel, Jerrold J., von Hippel, Frank A., Legler, Juliette, Maffini, Maricel V., Martin, Olwenn V., Myers, John Peterson, Nadal, Angel, Nerin, Cristina, Soto, Ana M., Trasande, Leonardo, Vandenberg, Laura N., Wagner, Martin, Zimmermann, Lisa, Zoeller, R. Thomas, and Scheringer, Martin
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Food contact materials and articles are ubiquitous in today’s globalized food system. Chemicals migrate from food contact materials into foodstuffs, but current regulatory requirements do not sufficiently protect public health from hazardous food contact chemicals (FCCs) because only individual substances used to make food contact materials are tested and mostly only for genotoxicity while endocrine disruption and other hazard properties are disregarded. Indeed, food contact materials are a known source of a wide range of hazardous chemicals, and they likely contribute to highly prevalent non-communicable diseases. Food contact materials can also include non-intentionally added substances (NIAS), which often are unknown and therefore not subject to risk assessment. To address these important shortcomings, we outline how the safety of food contact materials may be improved by (1) testing the overall migrate, including (unknown) NIAS, and (2) expanding toxicological testing beyond genotoxicity to multiple endpoints associated with non-communicable diseases relevant to human health. To identify mechanistic endpoints for testing, we group chronic health outcomes associated with chemical exposure into Six Clusters of Disease (SCOD) and we propose that finished food contact materials should be tested for their impacts on these SCOD. Future research should focus on development of robust, relevant and sensitive in vitro assays based on mechanistic information linked to the SCOD, e.g., through Adverse Outcome Pathways (AOPs) or Key Characteristics of Toxicants. Implementing this vision will improve prevention of chronic diseases that are associated with hazardous chemical exposures, including from food contact materials.
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- 2023
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21. Exposure to endocrine-disrupting chemicals in the USA: a population-based disease burden and cost analysis
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Attina, Teresa M, Hauser, Russ, Sathyanarayana, Sheela, Hunt, Patricia A, Bourguignon, Jean-Pierre, Myers, John Peterson, DiGangi, Joseph, Zoeller, R Thomas, and Trasande, Leonardo
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- 2016
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22. Maternal thyroid function during pregnancy or neonatal thyroid function and attention deficit hyperactivity disorder: A systematic review
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Drover, Samantha S. M., Villanger, Gro D., Aase, Heidi, Skogheim, Thea S., Longnecker, Matthew P., Zoeller, R. Thomas, Reichborn-Kjennerud, Ted, Knudsen, Gun P., Zeiner, Pål, and Engel, Stephanie M.
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- 2018
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23. NIEHS/FDA CLARITY-BPA research program update
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Heindel, Jerrold J., Newbold, Retha R., Bucher, John R., Camacho, Luísa, Delclos, K. Barry, Lewis, Sherry M., Vanlandingham, Michelle, Churchwell, Mona I., Twaddle, Nathan C., McLellen, Michelle, Chidambaram, Mani, Bryant, Matthew, Woodling, Kellie, Costa, Gonçalo Gamboa da, Ferguson, Sherry A., Flaws, Jodi, Howard, Paul C., Walker, Nigel J., Zoeller, R. Thomas, Fostel, Jennifer, Favaro, Carolyn, and Schug, Thaddeus T.
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- 2015
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24. Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women: a prospective cohort study
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Díaz Santana, Mary V., Hankinson, Susan E., Bigelow, Carol, Sturgeon, Susan R., Zoeller, R. Thomas, Tinker, Lesley, Manson, Jo Ann E., Calafat, Antonia M., Meliker, Jaymie R., and Reeves, Katherine W.
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- 2019
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25. Gestational thyroid hormone concentrations and risk of attention‐deficit hyperactivity disorder in the Norwegian Mother, Father and Child Cohort Study
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Engel, Stephanie M., primary, Villanger, Gro D., additional, Herring, Amy, additional, Nethery, Rachel C., additional, Drover, Samantha S. M., additional, Zoeller, R. Thomas, additional, Meltzer, Helle M., additional, Zeiner, Pal, additional, Knudsen, Gun Peggy, additional, Reichborn‐Kjennerud, Ted, additional, Longnecker, Matthew P., additional, and Aase, Heidi, additional
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- 2022
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26. Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement
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Solecki, Roland, Kortenkamp, Andreas, Bergman, Åke, Chahoud, Ibrahim, Degen, Gisela H., Dietrich, Daniel, Greim, Helmut, Håkansson, Helen, Hass, Ulla, Husoy, Trine, Jacobs, Miriam, Jobling, Susan, Mantovani, Alberto, Marx-Stoelting, Philip, Piersma, Aldert, Ritz, Vera, Slama, Remy, Stahlmann, Ralf, van den Berg, Martin, Zoeller, R. Thomas, and Boobis, Alan R.
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- 2017
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27. 137 - Endocrine-Disrupting Chemicals and Human Health
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Zoeller, R. Thomas and Heindel, Jerrold J.
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- 2023
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28. Gestational thyroid hormone concentrations and risk of attention‐deficit hyperactivity disorder in the Norwegian Mother, Father and Child Cohort Study.
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Engel, Stephanie M., Villanger, Gro D., Herring, Amy, Nethery, Rachel C., Drover, Samantha S. M., Zoeller, R. Thomas, Meltzer, Helle M., Zeiner, Pal, Knudsen, Gun Peggy, Reichborn‐Kjennerud, Ted, Longnecker, Matthew P., and Aase, Heidi
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ATTENTION-deficit hyperactivity disorder ,THYROID hormones ,LOGISTIC regression analysis ,MISSING data (Statistics) ,THYROTROPIN receptors ,THYROID hormone receptors ,COHORT analysis ,FETAL development ,ODDS ratio - Abstract
Background: Maternal thyroid function plays an important role in foetal brain development; however, little consensus exists regarding the relationship between normal variability in thyroid hormones and common neurodevelopmental disorders, such as attention‐deficit hyperactivity disorder (ADHD). Objective: We sought to examine the association between mid‐pregnancy maternal thyroid function and risk of clinically diagnosed ADHD in offspring. Methods: We conducted a nested case–control study in the Norwegian Mother, Father and Child Cohort Study. Among children born 2003 or later, we randomly sampled singleton ADHD cases obtained through linkage with the Norwegian Patient Registry (n = 298) and 554 controls. Concentrations of maternal triiodothyronine (T3), thyroxine (T4), T3‐Uptake, thyroid‐stimulating hormone (TSH) and thyroid peroxidase antibody (TPO‐Ab) were measured in maternal plasma, collected at approximately 17 weeks' gestation. Indices of free T4 (FT4i) and free T3 (FT3i) were calculated. We used multivariable adjusted logistic regression to calculate odds ratios and accounted for missing covariate data using multiple imputation. We used restricted cubic splines to assess non‐linear trends and provide flexible representations. We examined effect measure modification by dietary iodine and selenium intake. In sensitivity analyses, we excluded women with clinically significant thyroid disorders (n = 73). Results: High maternal T3 was associated with increased risk of ADHD (5th vs 1st quintile odds ratio 2.27, 95% confidence interval 1.21, 4.26). For FT4i, both the lowest and highest quintiles were associated with an approximate 1.6‐fold increase in risk of ADHD, with similar trends found for T4. The FT4i association was modified by dietary iodine intake such that the highest risk strata were confined to the low intake group. Conclusions: Both high and low concentrations of maternal thyroid hormones, although within population reference ranges, increase the risk of ADHD in offspring. Increased susceptibility may be found among women with low dietary intake of iodine and selenium. [ABSTRACT FROM AUTHOR]
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- 2023
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29. Endocrine-Disrupting Chemicals and Human Disease∗
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Heindel, Jerrold J., primary and Zoeller, R. Thomas, additional
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- 2016
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30. Contributors
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Aiello, Lloyd Paul, primary, Alatzoglou, Kyriaki S., additional, Alexander, Erik K., additional, Allan, Carolyn A., additional, Allolio, Bruno, additional, Amino, Nobuyuki, additional, Anawalt, Bradley D., additional, Angelos, Peter, additional, Arboleda, Valerie A., additional, Auchus, Richard J., additional, Axelrod, Lloyd, additional, Bahn, Rebecca S., additional, Baker, MD, PhD, FRACP, H.W. Gordon, additional, Barak, Shlomi, additional, Barnes, Randall B., additional, Barthel, Andreas, additional, Bastepe, Murat, additional, Beardsley, Emma K., additional, Beck-Peccoz, Paolo, additional, Bell, Graeme I., additional, Bi, Wenya Linda, additional, Bilezikian, John P., additional, Blum, Manfred, additional, Bonnema, Steen J., additional, Bornstein, Stefan R., additional, Bouillon, Roger, additional, Boulton, Andrew J.M., additional, Braunstein, Glenn D., additional, Bringhurst, F. Richard, additional, Broekmans, Frank J., additional, Bronstein, Marcello D., additional, Brown, Edward M., additional, Brown, Wendy A., additional, Bulun, Serdar E., additional, Burch, Henry B., additional, Burger, Henry G., additional, Burney, Richard O., additional, Burt, Morton G., additional, Cagliero, Enrico, additional, Callender, Glenda G., additional, Avancini Caramori, Maria Luiza, additional, Carey, Robert M., additional, Carling, Tobias, additional, Cavagnini, Francesco, additional, Cavallerano, Jerry D., additional, Challet, Etienne, additional, Chan, Shu Jin, additional, Chang, R. Jeffrey, additional, Chapurlat, Roland D., additional, Chatterjee, V. Krishna, additional, Chiofalo, Francesco, additional, Chiovato, Luca, additional, Cho, Kyung J., additional, Christison-Lagay, Emily, additional, Christophe, Daniel, additional, Chrousos, George P., additional, Cidlowski, John A., additional, Clemmons, David R., additional, Considine, Robert V., additional, Conti, Marco, additional, Copinschi, Georges, additional, Copps, Kyle D., additional, Cowley, Michael A., additional, Cuttler, Leona, additional, Dattani, Mehul T., additional, Davis, Stephen N., additional, De Felice, Mario, additional, De Groot, Leslie J., additional, de Kretser, David M., additional, DeFronzo, Ralph A., additional, Delli, Ahmed J., additional, Demay, Marie B., additional, Dennedy, Michael C., additional, Di Lauro, Roberto, additional, Dineen, Rosemary, additional, Ding, Su Ann, additional, Dinneen, Sean F., additional, Drucker, Daniel J., additional, Dumont, Jacques E., additional, Dungan, Kathleen M., additional, Dunn, Ian F., additional, Econs, Michael J., additional, Ehrmann, David A., additional, Eisenhofer, Graeme, additional, Ergun-Longmire, Berrin, additional, Eugster, Erica A., additional, Farooqi, Sadaf I., additional, Fassnacht, Martin, additional, Fauser, Bart C.J.M., additional, Fenzi, Gianfranco, additional, Ferrannini, Ele, additional, Findlay, David M., additional, Finlayson, Courtney Anne, additional, Fisher, Delbert A., additional, Francis, Isaac R., additional, Freeman, Mason W., additional, Frohman, Lawrence A., additional, Frydenberg, Mark, additional, Fuller, Peter J., additional, Gaglia, Jason L., additional, Galizia, Gianluigi, additional, Gardella, Thomas J., additional, Garvey, Katharine C., additional, Genant, Harry K., additional, German, Michael S., additional, Gevers, Evelien F., additional, Giraldi, Francesca Pecori, additional, Giudice, Linda C., additional, Giustina, Andrea, additional, Glasier, Anna, additional, Glorieux, Francis H., additional, Goldfine, Allison B., additional, Gooren, Louis J., additional, Gordon, David F., additional, Gregerson, Karen A., additional, Grogan, Raymon H., additional, Gross, Milton D., additional, Grossman, Ashley B., additional, Gruber, Matthias, additional, Guimarães, Valeria C., additional, Gurnell, Mark, additional, Haddad, Nadine G., additional, Haisenleder, Daniel J., additional, Handelsman, David J., additional, Hanks, John B., additional, Hannon, Mark J., additional, Harno, Erika, additional, Hebrok, Matthias, additional, Hedger, Mark P., additional, Hegedüs, Laszlo, additional, Heindel, Jerrold J., additional, Hernandez, Arturo, additional, Herndon, Maria K., additional, Ho, Ken K.Y., additional, Horseman, Nelson D., additional, Hughes, Ieuan A., additional, Hupfeld, Christopher J., additional, Hussain, Hero K., additional, Iodice, Valeria, additional, James, Benjamin C., additional, Jameson, J. Larry, additional, Jones, Glenville, additional, Josso, Nathalie, additional, Jüppner, Harald, additional, Juszczak, Agata, additional, Kalish, Jeffrey, additional, Kaplan, Edwin L., additional, Karavitaki, Niki, additional, Karczewska-Kupczewska, Monika, additional, Khattab, Ahmed, additional, Klein, David C., additional, Klein, Ronald, additional, Kleinau, Gunnar, additional, Koontz, Michaela, additional, Kopchick, John J., additional, Kopp, Peter, additional, Kowalska, Irina, additional, Krane, Stephen M., additional, Krohn, Knut, additional, Kronenberg, Henry M., additional, Lamos, Elizabeth M., additional, Lania, Andrea, additional, Lau, Sue Lynn, additional, Laws, Edward R., additional, Lazarus, John H., additional, Learoyd, Diana L., additional, Lebovitz, Harold E., additional, Lenmark, Åke, additional, List, Edward O., additional, Loveland, Kate, additional, Low, David A., additional, Macchia, Paolo E., additional, Maclaren, Noel K., additional, Madeiros-Neto, Geraldo, additional, Maenhaut, Carine, additional, Maes, Christa, additional, Main, Katharina M., additional, Malchoff, Carl D., additional, Malchoff, Diana M., additional, Malik, Rayaz A., additional, Mandel, Susan J., additional, Mantzoros, Christos S., additional, Maratos-Flier, Eleftheria, additional, Marino, Michele, additional, Marshall, John C., additional, Martin, T. John, additional, Martin, Thomas F.J., additional, Mathias, Christopher J., additional, McGee, Elizabeth A., additional, McKenzie, Travis, additional, McLachlan, Robert I., additional, Meier, Juris J., additional, Melmed, Shlomo, additional, Metzger, Boyd E., additional, Meyer-Bahlburg, Heino F.L., additional, Millar, Robert P., additional, Miller, Walter L., additional, Misra, Madhusmita, additional, Molitch, Mark E., additional, Moravek, Molly B., additional, Morris, Damian G., additional, Nagar, Sapna, additional, Nakamoto, Jon, additional, New, Maria I., additional, Nieman, Lynnette K., additional, Nilson, John H., additional, Ntali, Georgia, additional, O’Bryan, Moira, additional, O’Rahilly, Stephen, additional, Öberg, Kjell, additional, Olefsky, Jerrold M., additional, Olson, Matthew T., additional, Pacak, Karel, additional, Pacini, Furio, additional, Padia, Shetal H., additional, Paschke, Ralf, additional, Pasquel, Francisco J., additional, Perry, Katherine Wesseling, additional, Persani, Luca, additional, Philipson, Louis H., additional, Pina, Christian, additional, Pomposelli, Frank B., additional, Potts, John T., additional, Quigley, Charmian A., additional, Quinkler, Marcus O., additional, Quirk, Christine Campion, additional, Rajpert-De Meyts, Ewa, additional, Ravussin, Eric, additional, Ray, David W., additional, Refetoff, Samuel, additional, Retnakaran, Ravi, additional, Rey, Rodolfo A., additional, Rhodes, Christopher J., additional, Ridgway, E. Chester, additional, Risbridger, Gail P., additional, Rizza, Robert A., additional, Robinson, Bruce G., additional, Roger, Pierre P., additional, Rosenfeld, Michael G., additional, Rosenfield, Robert L., additional, Rossing, Peter, additional, Rubin, Robert T., additional, Rubio, Ileana G.S., additional, Ruderman, Neil B., additional, Russo, Jose, additional, Russo, Irma H., additional, Salusky, Isidro B., additional, Santoro, Nanette, additional, Scully, Kathleen M., additional, Sexton, Patrick M., additional, Shulman, Gerald I., additional, Silva, Paolo S., additional, Silverberg, Shonni J., additional, Singer, Frederick R., additional, Skakkebaek, Niels E., additional, Skaznik-Wikiel, Malgorzata E., additional, Skowronska-Krawczyk, Dorota, additional, Smith, Carolyn L., additional, Smith, Philip W., additional, Smith, Roger, additional, Smith, Steven R., additional, Snyder, Peter J., additional, St. Germain, Donald L., additional, St-Arnaud, René, additional, Steiner, Donald F., additional, Stewart, Paul M., additional, Strączkowski, Marek, additional, Strauss, Jerome F., additional, Styne, Dennis M., additional, Swan, Karena L., additional, Swerdloff, Ronald S., additional, Tacon, Lyndal J., additional, Tello, Javier A., additional, Thakker, Rajesh V., additional, Thompson, Christopher J., additional, Timmers, Henri J.L.M., additional, Toppari, Jorma, additional, Traub, Michael L., additional, Tsoukas, Michael A., additional, Udelsman, Robert, additional, Umpierrez, Guillermo E., additional, Van den Berghe, Greet, additional, Vassart, Gilbert, additional, Vernon, Ashley H., additional, Vilain, Eric, additional, Visser, Theo J., additional, Vitti, Paolo, additional, Walford, Geoffrey A., additional, Wang, Christina, additional, Weetman, Anthony P., additional, Weigel, Nancy L., additional, Weir, Gordon C., additional, Weiss, Roy E., additional, White, Anne, additional, White, Kenneth E., additional, White, Morris F., additional, Whyte, Michael P., additional, Wiersinga, Wilmar M., additional, Willenberg, Holger S., additional, Wolfsdorf, Joseph I., additional, Wondisford, Fredric E., additional, Wong, Ka Kit, additional, Wysolmerski, John J., additional, Yau, Mabel, additional, Young, Morag J., additional, Younk, Lisa M., additional, Yu, Run, additional, Yuen, Tony, additional, Zeiger, Martha A., additional, Zinman, Bernard, additional, and Zoeller, R. Thomas, additional
- Published
- 2016
- Full Text
- View/download PDF
31. The Price We Pay for the Convenience of Plastics.
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Zoeller, R Thomas
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PLASTICS ,FLUOROALKYL compounds ,MARKETING ,ENDOCRINE disruptors - Abstract
A recent study published in the Journal of the Endocrine Society estimates that the healthcare costs associated with chemicals in plastics in the United States amount to approximately $250 billion per year, or 1.22% of the country's gross domestic product. However, this figure is considered to be a significant underestimate. Plastics are widely used in single-use packaging, construction materials, medical devices, and various industries. Plastics contain thousands of chemicals that can leach into products and pose risks to human health. The study highlights the need to reduce the production of new plastics in order to mitigate the disease burden and economic costs associated with plastic use. [Extracted from the article]
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- 2024
- Full Text
- View/download PDF
32. Toward the Production of Safer Chemicals: A new protocol for safer chemical design is helping to overcome gaps in 'traditional' toxicology and improve upon federal regulations for endocrine-disrupting chemicals.
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Zoeller, R. Thomas and Myers, Pete
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ENDOCRINE disruptors ,FEDERAL regulation ,MEDICAL sciences ,CHEMICAL testing ,CHEMICAL engineering ,THYROID hormone receptors - Abstract
The Tiered Protocol for Endocrine Disruption (TiPED) is a new protocol being developed to improve regulations for endocrine-disrupting chemicals (EDCs). These chemicals can have harmful effects on human health and the environment, even at low concentrations. TiPED consists of five testing tiers to evaluate the potential endocrine disruption of chemicals, saving time and resources by only conducting expensive testing on a small fraction of chemicals. The proposed European "Chemical Strategy for Sustainability" also emphasizes the need for safer chemicals and supports funding for sustainable replacements for hazardous chemicals. [Extracted from the article]
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- 2022
33. Endocrine-Disrupting Activity of Hydraulic Fracturing Chemicals and Adverse Health Outcomes After Prenatal Exposure in Male Mice
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Kassotis, Christopher D., Klemp, Kara C., Vu, Danh C., Lin, Chung-Ho, Meng, Chun-Xia, Besch-Williford, Cynthia L., Pinatti, Lisa, Zoeller, R. Thomas, Drobnis, Erma Z., Balise, Victoria D., Isiguzo, Chiamaka J., Williams, Michelle A., Tillitt, Donald E., and Nagel, Susan C.
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- 2015
34. Estimating Burden and Disease Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union
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Trasande, Leonardo, Zoeller, R. Thomas, Hass, Ulla, Kortenkamp, Andreas, Grandjean, Philippe, Myers, John Peterson, DiGangi, Joseph, Bellanger, Martine, Hauser, Russ, Legler, Juliette, Skakkebaek, Niels E., and Heindel, Jerrold J.
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- 2015
35. Neurobehavioral Deficits, Diseases, and Associated Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union
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Bellanger, Martine, Demeneix, Barbara, Grandjean, Philippe, Zoeller, R. Thomas, and Trasande, Leonardo
- Published
- 2015
36. Endocrine Disruption in Human Placenta: Expression of the Dioxin-Inducible Enzyme, Cyp1a1, Is Correlated With That of Thyroid Hormone-Regulated Genes
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Wadzinski, Thomas L., Geromini, Katherine, McKinley Brewer, Judy, Bansal, Ruby, Abdelouahab, Nadia, Langlois, Marie-France, Takser, Larissa, and Zoeller, R. Thomas
- Published
- 2014
37. Polybrominated Diphenyl Ether (DE-71) Interferes With Thyroid Hormone Action Independent of Effects on Circulating Levels of Thyroid Hormone in Male Rats
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Bansal, Ruby, Tighe, Daniel, Danai, Amin, Rawn, Dorothea F. K., Gaertner, Dean W., Arnold, Doug L., Gilbert, Mary E., and Zoeller, R. Thomas
- Published
- 2014
38. Urinary Phthalate Biomarkers and Bone Mineral Density in Postmenopausal Women
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Reeves, Katherine W, primary, Vieyra, Gabriela, additional, Grimes, Nydjie P, additional, Meliker, Jaymie, additional, Jackson, Rebecca D, additional, Wactawski-Wende, Jean, additional, Wallace, Robert, additional, Zoeller, R Thomas, additional, Bigelow, Carol, additional, Hankinson, Susan E, additional, Manson, JoAnn E, additional, Cauley, Jane A, additional, and Calafat, Antonia M, additional
- Published
- 2021
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39. Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project
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Kortenkamp, Andreas, Axelstad, Marta, Baig, Asma H., Bergman, Ake, Bornehag, Carl-Gustav, Cenijn, Peter, Christiansen, Sofie, Demeneix, Barbara, Derakhshan, Arash, Fini, Jean-Baptiste, Fraedrich, Caroline, Hamers, Timo, Hellwig, Lina, Koehrle, Josef, Korevaar, Tim I. M., Lindberg, Johan, Martin, Olwenn, Meima, Marcel E., Mergenthaler, Philipp, Nikolov, Nikolai, Du Pasquier, David, Peeters, Robin P., Platzack, Bjorn, Ramhoj, Louise, Remaud, Sylvie, Renko, Kostja, Scholze, Martin, Stachelscheid, Harald, Svingen, Terje, Wagenaars, Fabian, Wedebye, Eva Bay, Zoeller, R. Thomas, Physiologie moléculaire et adaptation (PhyMA), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), E&H: Environmental Health and Toxicology, AIMMS, and Internal Medicine
- Subjects
Project Report ,endocrine system ,Thyroid Hormones ,[SDV]Life Sciences [q-bio] ,education ,Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) ,brain development ,Test method development ,In Vitro Techniques ,lcsh:Chemistry ,test method validation ,SDG 17 - Partnerships for the Goals ,Naturvetenskap ,Drug Discovery ,Animals ,Humans ,Thyroid hormone system ,test method development ,lcsh:QH301-705.5 ,Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) ,Endocrine disruptors ,health care economics and organizations ,Risk assessment ,Internet ,Brain ,risk assessment ,Brain development ,High-Throughput Screening Assays ,endocrine disruptors ,lcsh:Biology (General) ,lcsh:QD1-999 ,thyroid hormone system ,Blood-Brain Barrier ,Test method validation ,Natural Sciences - Abstract
Copyright © 2020 by the authors. The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully inadequate. There are currently no internationally validated in vitro assays, and test methods that can capture the consequences of diminished or enhanced thyroid hormone action on the developing brain are missing entirely. These gaps put the public at risk and risk assessors in a difficult position. Decisions about the status of chemicals as thyroid hormone system disruptors currently are based on inadequate toxicity data. The ATHENA project (Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies) has been conceived to address these gaps. The project will develop new test methods for the disruption of thyroid hormone transport across biological barriers such as the blood–brain and blood–placenta barriers. It will also devise methods for the disruption of the downstream effects on the brain. ATHENA will deliver a testing strategy based on those elements of the thyroid hormone system that, when disrupted, could have the greatest impact on diminished or enhanced thyroid hormone action and therefore should be targeted through effective testing. To further enhance the impact of the ATHENA test method developments, the project will develop concepts for better international collaboration and development in the area of thyroid hormone system disruptor identification and regulation. EU Horizon 2020 programme, grant number 825161
- Published
- 2020
40. Contributors
- Author
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Abu Dayyeh, Barham K., Agostini, Maura, Aiello, Lloyd Paul, Alicic, Radica Z., Anawalt, Bradley D., Ang, Lynn, Angelidi, Angeliki M., Antonio, Leen, Armstrong, David G., Arner, Peter, Assié, Guillaume, Athonvarangkul, Diana, Auchus, Richard J., Avery, Michael B., Avram, Anca M., Baloch, Zubair W., Bancos, Irina, Barb, Diana, Barkhoudarian, Garni, Basaria, Shehzad, Basham, Kaitlin J., Bashari, Waiel, Bastepe, Murat, Batterham, Rachel L., Bauer, Elizabeth M., Bellin, Melena D., Bertherat, Jérôme, Berthon, Annabel, Bhasin, Shalender, Bilezikian, John P., Billington, Emma O., Boelen, Anita, Bouillon, Roger, Brada, Michael, Brent, Gregory A., Broekmans, Frank J., Bronstein, Marcello D., Brown, Edward M., Bulun, Serdar E., Burch, Henry B., Burghard, Anne Claire, Burney, Richard O., Pop-Busui, Rodica, Cagliero, Enrico, Cameron, Sharon, Caoili, Elaine M., Carmeliet, Geert, Cavallerano, Jerry D., Chatterjee, Krishna, Chen, Zi-Jiang, Cheung, N. Wah, Christian, Helen C., Cidlowski, John A., Clavijo, Leonardo C., Clifton-Bligh, Roderick J., Considine, Robert V., Conti, Marco, Copps, Kyle D., Corcuff, Jean- Benoît, D’Alessio, David, Dattani, Mehul T., Davey, Rachel A., Davis, Stephen N., De Felice, Mario, de Kretser, David, DeFranco, Donald B., Demay, Marie B., DeMayo, Francesco J., De Santis, Pascual, Deutsch, Madeline B., Dhatariya, Ketan, Dhillon, Vaninder K., Di Lauro, Roberto, Dillon, Joseph S., Dinneen, Sean F., Doherty, Gerard M., Donahoo, William Troy, Econs, Michael J., Egan, Aoife M., Ehrhardt, Nicole, Ehrmann, David A., Eisenhofer, Graeme, El-Khairi, Ranna, Elisei, Rossella, Else, Tobias, Erickson, Lori A., Erinjeri, Neeta J., Eszlinger, Markus, Eugster, Erica A., Evert, Alison B., Faix, James D., Farooqi, I. Sadaf, Fassnacht, Martin, Fauser, Bart C.J.M., Findlay, David M., Fliers, Eric, Freeman, Mason W., Frydenberg, Mark, Fuller, Peter J., Gagliano-Jucá, Thiago, Gardella, Thomas J., Garrahy, Aoife, Garvey, W. Timothy, German, Michael S., Gershengorn, Marvin C., Gild, Matti, Gilliam, Lisa K., Giudice, Linda C., Glezer, Andrea, Glorieux, Francis H., Goodpaster, Bret H., Grinman, Diego Y., Guasti, Leonardo, Gurnell, Mark, Habra, Mouhammed Amir, Haddad, Nadine G., Halperin, Daniel M., Hammes, Stephen R., Hardman, Sarah, Harmon, Jamie S., Haugen, Bryan R., Hebrok, Matthias, Hedger, Mark P., Heindel, Jerrold J., Hirsch, Irl B., Hobbs, Robin M., Hollenberg, Anthony N., Hruska, Keith A., Husebye, Eystein, Iacovazzo, Donato, Ilie, Mirela Diana, Imel, Erik A., Isaac, Adam L., Jameson, J. Larry, Jasuja, Ravi, Jayasena, Channa N., Johannsson, Gudmundur, Jones, Glenville, Jonklaas, Jacqueline, Jørgensen, Niels, Jüppner, Harald, Juul, Anders, Kahaly, George J., Karavitaki, Niki, Katugampola, Harshini, Keevil, Brian, Kelley, David E., Kellogg, Todd Andrew, Kelly, David F., Klein, Ronald, Kleinau, Gunnar, Koniares, Katherine, Kopp, Peter, Korbonits, Márta, Korevaar, Tim I.M., Koulouri, Olympia, Krausz, Csilla, Kronenberg, Henry M., La Greca, Amanda, Lamos, Elizabeth M., Lebovitz, Harold E., Hong Lee, Alan Chun, Legro, Richard S., Lenders, Jacques W.M., Lerario, Antonio M., Lernmark, Åke, Lightman, Stafford L., Lin, David S., Liu, Eva S., Lo, Janet, Loomba, Lindsey A., Loveland, Kate L., Lue, Tom F., Lundgren, Markus, MacFarlane, James Robert, Magee, Gregory A., Maes, Christa, Maharaj, Avinaash, Main, Katharina M., Makaronidis, Janine M., Malina, Robert, Mannstadt, Michael, Manohar, Paul, Mantzoros, Christos S., Marazuela, Mónica, Matrone, Antonio, Maxwell, Jessica E., McCartney, Christopher R., McGee, Elizabeth A., Melanson, Edward L., Melmed, Shlomo, Mendelson, Carole R., Merke, Deborah P., Mesiano, Sam, Metherell, Louise A., Miller, Barbra S., Mizokami-Stout, Kara, Mohan, Dipika R., Molitch, Mark E., Moran, Carla, Moravek, Molly B., Neumann, Susanne, Neumiller, Joshua J., Newell-Price, John D.C., Newey, Paul J., Norwitz, Errol R., O’Donnell, Liza, O’Rahilly, Stephen, Oakley, Robert H., Oberfield, Sharon E., Orellana, Minerva, Mete, Ozgur, Pacak, Karel, Pace-Asciak, Pia, Page, Stephanie T., Paschke, Ralf, Pasquel, Francisco J., Pearce, Elizabeth N., Peters, Anne L., Pook, David W., Potts, Callum A., Potts, John T., Jr, Purcell, Sarah A., Raff, Hershel, Ragnarsson, Oskar, Rajpert-De Meyts, Ewa, Ramos-Levi, Ana M., Rao, Sarika N., Rastrelli, Giulia, Raverot, Gérald, Ray, David W., Razavi, Christopher R., Reed-Maldonado, Amanda B., Reid, Ian R., Retnakaran, Ravi, Rickels, Michael R., Riddell, Michael Charles, Rinaudo, Paolo, Risbridger, Gail P., Robertson, R. Paul, Robinson, Bruce G., Rogol, Alan D., Romei, Cristina, Rosenfelder, Nicola, Rowen, Tami S., Ruderman, Neil B., Rushing, John, Russell, Jonathon O., Russo, Jose, Rydén, Mikael, Santoro, Nanette, Schlegel, Peter N., Schoenmakers, Erik, Schoenmakers, Nadia, Senanayake, Russell Martin, Shaear, Mohammad, Shalev, Anath, Shields, James, Shimy, Kim, Shindel, Alan W., Shulman, Gerald I., Silva, Paolo S., Simmons, David, Simon, James A., Singer, Frederick R., Sipos, Jennifer A., Skaznik-Wikiel, Malgorzata E., Smallridge, Robert C., Smith, Christopher J., Smith, Roger, Smith, Ulf, Snyder, Peter J., Solda, Francesca, Speiser, Phyllis W., St-Arnaud, René, Stewart, Elizabeth A., Stowasser, Michael, Straseski, Joely, Strauss, Jerome F., III, Styne, Dennis M., Swerdloff, Ronald S., Tabarin, Antoine, Tanavde, Ved, Taïeb, David, Thakker, Rajesh V., Thompson, Christopher J., Timmers, Henri J.L.M., Toppari, Jorma, Torpy, David J., Tsang, Venessa, Tsoukas, Michael A., Tufano, Ralph P., Tuttle, Katherine R., Udelsman, Robert, Umpierrez, Guillermo, Upton, Thomas J., Vaidya, Anand, Val, Pierre, Vasiljevic, Alexandre, Vaughan, Denis A., Vella, Adrian, Verlinden, Lieve, Vietor, Nicole O., Viglianti, Benjamin L., Vilain, Eric, Barisson Villares Fragoso, Maria Candida, Visser, W. Edward, Walford, Geoffrey, Walker, Marcella D., Wang, Christina, Weetman, Anthony P., Wei, Daimin, White, Kenneth E., White, Morris F., White, Perrin C., Whyte, Michael P., Williams, Matthew James, Witchel, Selma Feldman, Wong, Ka Kit, Wu, Frederick C.W., Wysolmerski, John J., Young, Morag J., Zennaro, Maria-Christina, Zimmerman, Michael B., and Zoeller, R. Thomas
- Published
- 2023
- Full Text
- View/download PDF
41. Thresholds and Endocrine Disruptors: An Endocrine Society Policy Perspective
- Author
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Demeneix, Barbara, primary, Vandenberg, Laura N, additional, Ivell, Richard, additional, and Zoeller, R Thomas, additional
- Published
- 2020
- Full Text
- View/download PDF
42. Maternal serum perfluoroalkyl substance mixtures and thyroid hormone concentrations in maternal and cord sera: The HOME Study
- Author
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Lebeaux, Rebecca M., primary, Doherty, Brett T., additional, Gallagher, Lisa G., additional, Zoeller, R. Thomas, additional, Hoofnagle, Andrew N., additional, Calafat, Antonia M., additional, Karagas, Margaret R., additional, Yolton, Kimberly, additional, Chen, Aimin, additional, Lanphear, Bruce P., additional, Braun, Joseph M., additional, and Romano, Megan E., additional
- Published
- 2020
- Full Text
- View/download PDF
43. Maternal, cord, and three‐year‐old child serum thyroid hormone concentrations in the Health Outcomes and Measures of the Environment study
- Author
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Doherty, Brett T., primary, Kosarek, Noelle, additional, Hoofnagle, Andy N., additional, Xu, Yingying, additional, Zoeller, R. Thomas, additional, Yolton, Kimberly, additional, Chen, Aimin, additional, Lanphear, Bruce P., additional, Braun, Joseph M., additional, and Romano, Megan E., additional
- Published
- 2020
- Full Text
- View/download PDF
44. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification
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La Merrill, Michele A., primary, Vandenberg, Laura N., additional, Smith, Martyn T., additional, Goodson, William, additional, Browne, Patience, additional, Patisaul, Heather B., additional, Guyton, Kathryn Z., additional, Kortenkamp, Andreas, additional, Cogliano, Vincent J., additional, Woodruff, Tracey J., additional, Rieswijk, Linda, additional, Sone, Hideko, additional, Korach, Kenneth S., additional, Gore, Andrea C., additional, Zeise, Lauren, additional, and Zoeller, R. Thomas, additional
- Published
- 2019
- Full Text
- View/download PDF
45. The Use and Misuse of Historical Controls in Regulatory Toxicology: Lessons from the CLARITY-BPA Study
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Vandenberg, Laura N, primary, Prins, Gail S, additional, Patisaul, Heather B, additional, and Zoeller, R Thomas, additional
- Published
- 2019
- Full Text
- View/download PDF
46. Maternal polybrominated diphenyl ether (PBDE) exposure and thyroid hormones in maternal and cord sera: the HOME Study, Cincinnati, USA
- Author
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Vuong, Ann M., Webster, Glenys M., Romano, Megan E., Braun, Joseph M., Zoeller, R. Thomas, Hoofnagle, Andrew N., Sjodin, Andreas, Yolton, Kimberly, Lanphear, Bruce P., and Chen, Aimin
- Subjects
Thyroxine -- Research -- Physiological aspects ,Pregnant women -- Health aspects -- Research ,Environmental issues ,Health - Abstract
BACKGROUND: Polybrominated diphenyl ethers (PBDEs) reduce blood concentrations of thyroid hormones in laboratory animals, but it is unclear whether PBDEs disrupt thyroid hormones in pregnant women or newborn infants. OBJECTIVES: We investigated the relationship between maternal PBDE levels and thyroid hormone concentrations in maternal and cord sera. Methods: we used data from the Health Outcomes and Measures of the Environment (HOME) Study, a prospective birth cohort of 389 pregnant women in Cincinnati, Ohio, who were enrolled from 2003 through 2006 and delivered singleton infants. Maternal serum PBDE concentrations were measured at enrollment (16 ± 3 weeks of gestation). Thyroid hormone concentrations were measured in maternal serum at enrollment (n = 187) and in cord serum samples (n = 256). RESULTS: Median maternal serum concentrations of BDEs 28 and 47 were 1.0 and 19.1 ng/g lipid, respectively. A 10-fold increase in BDEs 28 and 47 concentrations was associated with a 0.85-µg/dL [95% confidence interval (CI): 0.05, 1.64] and 0.82-µg/dL (95% CI: 0.12, 1.51) increase in maternal total thyroxine concentrations ([TT.sub.4]), respectively. Both congeners were also positively associated with maternal free thyroxine ([FT.sub.4]). We also observed positive associations between BDE-47 and maternal total and free triiodothyronine ([TT.sub.4] and [FT.sub.3]). A 10-fold increase in BDE-28 was associated with elevated [FT.sub.3] concentrations (β = 0.14 µg/mL; 95% CI: 0.02, 0.26). In contrast, maternal PBDE levels were not associated with thyroid hormone concentrations in cord serum. CONCLUSIONS: These findings suggest that maternal PBDE exposure, particularly BDEs 28 and 47, are associated with maternal concentrations of [T.sub.4] and [T.sub.3] during pregnancy. http://dx.doi.org/10.1289/ehp.1408996, Introduction Polybrominated diphenyl ethers (PBDEs), synthetic flame retardants, have been used in the manufacture of consumer products, including furniture foam, carpet padding, and electronics. Because they are semivolatile and are [...]
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- 2015
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47. Thyroid hormones and neurobehavioral functions among adolescents chronically exposed to groundwater with geogenic arsenic in Bangladesh
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Khan, Khalid M., primary, Parvez, Faruque, additional, Zoeller, R. Thomas, additional, Hocevar, Barbara A., additional, Kamendulis, Lisa M., additional, Rohlman, Diane, additional, Eunus, Mahbubul, additional, and Graziano, Joseph, additional
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- 2019
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48. CLARITY-BPA: Bisphenol A or Propylthiouracil on Thyroid Function and Effects in the Developing Male and Female Rat Brain
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Bansal, Ruby, primary and Zoeller, R Thomas, additional
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- 2019
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49. Update on Activities in Endocrine Disruptor Research and Policy
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Zoeller, R Thomas, primary, Doan, Loretta, additional, Demeneix, Barbara, additional, Gore, Andrea C, additional, Nadal, Angel, additional, and Tan, Shirlee, additional
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- 2019
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50. Predictors of urinary phthalate biomarker concentrations in postmenopausal women
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Reeves, Katherine W., primary, Santana, Mary Díaz, additional, Manson, JoAnn E., additional, Hankinson, Susan E., additional, Zoeller, R. Thomas, additional, Bigelow, Carol, additional, Hou, Lifang, additional, Wactawski-Wende, Jean, additional, Liu, Simin, additional, Tinker, Lesley, additional, and Calafat, Antonia M., additional
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- 2019
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