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2,763 results on '"S. Barrow"'

1. PCCA Appoints Kenneth S. Barrow as General Counsel

Subjects
Chief operating officers -- Appointments, resignations and dismissals, Attorneys -- Appointments, resignations and dismissals, General interest, News, opinion and commentary
Abstract

Houston: PCCA proudly announces the appointment of Kenneth S. Barrow, JD, as its General Counsel. Bringing a wealth of experience as an attorney and business executive, Barrow joins PCCA following [...]

Published
2024

2. PCCA Appoints Kenneth S. Barrow as General Counsel

Subjects
Benchmark Electronics Inc. -- Officials and employees, Chief operating officers -- Appointments, resignations and dismissals, Attorneys -- Appointments, resignations and dismissals, Banking, finance and accounting industries, Business
Abstract

Houston, Texas, Jan. 29, 2024 (GLOBE NEWSWIRE) -- PCCA proudly announces the appointment of Kenneth S. Barrow, JD, as its General Counsel. Bringing a wealth of experience as an attorney [...]

Published
2024

8. Repurposed inhibitor of bacterial dihydrodipicolinate reductase exhibits effective herbicidal activity

Author

Emily R. R. Mackie, Andrew S. Barrow, Marie-Claire Giel, Mark D. Hulett, Anthony R. Gendall, Santosh Panjikar, and Tatiana P. Soares da Costa

Subjects
Biology (General), QH301-705.5
Abstract

Abstract Herbicide resistance represents one of the biggest threats to our natural environment and agricultural sector. Thus, new herbicides are urgently needed to tackle the rise in herbicide-resistant weeds. Here, we employed a novel strategy to repurpose a ‘failed’ antibiotic into a new and target-specific herbicidal compound. Specifically, we identified an inhibitor of bacterial dihydrodipicolinate reductase (DHDPR), an enzyme involved in lysine biosynthesis in plants and bacteria, that exhibited no antibacterial activity but severely attenuated germination of the plant Arabidopsis thaliana. We confirmed that the inhibitor targets plant DHDPR orthologues in vitro, and exhibits no toxic effects against human cell lines. A series of analogues were then synthesised with improved efficacy in germination assays and against soil-grown A. thaliana. We also showed that our lead compound is the first lysine biosynthesis inhibitor with activity against both monocotyledonous and dicotyledonous weed species, by demonstrating its effectiveness at reducing the germination and growth of Lolium rigidum (rigid ryegrass) and Raphanus raphanistrum (wild radish). These results provide proof-of-concept that DHDPR inhibition may represent a much-needed new herbicide mode of action. Furthermore, this study exemplifies the untapped potential of repurposing ‘failed’ antibiotic scaffolds to fast-track the development of herbicide candidates targeting the respective plant enzymes.

Published
2023
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9. GAINN: The Galaxy Assembly and Interaction Neural Networks for High-redshift JWST Observations

Author

Lillian Santos-Olmsted, Kirk S. S. Barrow, and Tilman Hartwig

Subjects
Hydrodynamical simulations, High-redshift galaxies, James Webb Space Telescope, Galaxy properties, Neural networks, Astrophysics, QB460-466
Abstract

We present the Galaxy Assembly and Interaction Neural Networks ( Gainn ), a series of artificial neural networks for predicting the redshift, stellar mass, halo mass, and mass-weighted age of simulated galaxies based on James Webb Space Telescope (JWST) photometry. Our goal is to determine the best neural network for predicting these variables at 11 < z < 15. The parameters of the optimal neural network can then be used to estimate these variables for real, observed galaxies. The inputs of the neural networks are JWST filter magnitudes of a subset of five broadband filters (F150W, F200W, F277W, F356W, and F444W) and two medium-band filters (F162M and F182M). We compare the performance of the neural networks using different combinations of these filters, as well as different activation functions and numbers of layers. The best neural network predicted redshift with a normalized rms error of ${0.010}_{-0.001}^{+0.003}$ , stellar mass with rms = ${0.089}_{-0.022}^{+0.044}$ , halo mass with a mean-squared error of ${0.022}_{-0.008}^{+0.014}$ , and mass-weighted age with rms = ${12.466}_{-2.408}^{+5.065}$ . We also test the performance of Gainn on real data from MACS0647JD, an object observed by JWST. Predictions from Gainn for the first projection of the object (JD1) have normalized bias 〈Δ z 〉 < 0.00228, which is significantly smaller than found with template-fitting methods. We find that the optimal filter combination is F277W, F356W, F162M, and F200W when considering both theoretical accuracy and observational resources from JWST.

Published
2024
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10. The AGORA High-resolution Galaxy Simulations Comparison Project. IV. Halo and Galaxy Mass Assembly in a Cosmological Zoom-in Simulation at z ≤ 2

Author

Santi Roca-Fàbrega, Ji-hoon Kim, Joel R. Primack, Minyong Jung, Anna Genina, Loic Hausammann, Hyeonyong Kim, Alessandro Lupi, Kentaro Nagamine, Johnny W. Powell, Yves Revaz, Ikkoh Shimizu, Clayton Strawn, Héctor Velázquez, Tom Abel, Daniel Ceverino, Bili Dong, Thomas R. Quinn, Eun-jin Shin, Alvaro Segovia-Otero, Oscar Agertz, Kirk S. S. Barrow, Corentin Cadiou, Avishai Dekel, Cameron Hummels, Boon Kiat Oh, Romain Teyssier, and The AGORA Collaboration

Subjects
Hydrodynamical simulations, Galaxy formation, Galaxy evolution, Astrophysics, QB460-466
Abstract

In this fourth paper from the AGORA Collaboration, we study the evolution down to redshift z = 2 and below of a set of cosmological zoom-in simulations of a Milky Way mass galaxy by eight of the leading hydrodynamic simulation codes. We also compare this CosmoRun suite of simulations with dark matter-only simulations by the same eight codes. We analyze general properties of the halo and galaxy at z = 4 and 3, and before the last major merger, focusing on the formation of well-defined rotationally supported disks, the mass–metallicity relation, the specific star formation rate, the gas metallicity gradients, and the nonaxisymmetric structures in the stellar disks. Codes generally converge well to the stellar-to-halo mass ratios predicted by semianalytic models at z ∼ 2. We see that almost all the hydro codes develop rotationally supported structures at low redshifts. Most agree within 0.5 dex with the observed mass–metallicity relation at high and intermediate redshifts, and reproduce the gas metallicity gradients obtained from analytical models and low-redshift observations. We confirm that the intercode differences in the halo assembly history reported in the first paper of the collaboration also exist in CosmoRun , making the code-to-code comparison more difficult. We show that such differences are mainly due to variations in code-dependent parameters that control the time stepping strategy of the gravity solver. We find that variations in the early stellar feedback can also result in differences in the timing of the low-redshift mergers. All the simulation data down to z = 2 and the auxiliary data will be made publicly available.

Published
2024
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11. The AGORA High-resolution Galaxy Simulations Comparison Project. VI. Similarities and Differences in the Circumgalactic Medium

Author

Clayton Strawn, Santi Roca-Fàbrega, Joel R. Primack, Ji-hoon Kim, Anna Genina, Loic Hausammann, Hyeonyong Kim, Alessandro Lupi, Kentaro Nagamine, Johnny W. Powell, Yves Revaz, Ikkoh Shimizu, Héctor Velázquez, Tom Abel, Daniel Ceverino, Bili Dong, Minyong Jung, Thomas R. Quinn, Eun-jin Shin, Kirk S. S. Barrow, Avishai Dekel, Boon Kiat Oh, Nir Mandelker, Romain Teyssier, Cameron Hummels, Soumily Maji, Antonio Man, Paul Mayerhofer, and the AGORA Collaboration

Subjects
Circumgalactic medium, Hydrodynamical simulations, Computational astronomy, Astronomical simulations, Astrophysics, QB460-466
Abstract

We analyze the circumgalactic medium (CGM) for eight commonly-used cosmological codes in the AGORA collaboration. The codes are calibrated to use identical initial conditions, cosmology, heating and cooling, and star formation thresholds, but each evolves with its own unique code architecture and stellar feedback implementation. Here, we analyze the results of these simulations in terms of the structure, composition, and phase dynamics of the CGM. We show properties such as metal distribution, ionization levels, and kinematics are effective tracers of the effects of the different code feedback and implementation methods, and as such they can be highly divergent between simulations. This is merely a fiducial set of models, against which we will in the future compare multiple feedback recipes for each code. Nevertheless, we find that the large parameter space these simulations establish can help disentangle the different variables that affect observable quantities in the CGM, e.g., showing that abundances for ions with higher ionization energy are more strongly determined by the simulation’s metallicity, while abundances for ions with lower ionization energy are more strongly determined by the gas density and temperature.

Published
2024
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12. JWST Reveals a Possible z ∼ 11 Galaxy Merger in Triply Lensed MACS0647–JD

Author

Tiger Yu-Yang Hsiao, Dan Coe, Abdurro’uf, Lily Whitler, Intae Jung, Gourav Khullar, Ashish Kumar Meena, Pratika Dayal, Kirk S. S. Barrow, Lillian Santos-Olmsted, Adam Casselman, Eros Vanzella, Mario Nonino, Yolanda Jiménez-Teja, Masamune Oguri, Daniel P. Stark, Lukas J. Furtak, Adi Zitrin, Angela Adamo, Gabriel Brammer, Larry Bradley, Jose M. Diego, Erik Zackrisson, Steven L. Finkelstein, Rogier A. Windhorst, Rachana Bhatawdekar, Taylor A. Hutchison, Tom Broadhurst, Paola Dimauro, Felipe Andrade-Santos, Jan J. Eldridge, Ana Acebron, Roberto J. Avila, Matthew B. Bayliss, Alex Benítez, Christian Binggeli, Patricia Bolan, Maruša Bradač, Adam C. Carnall, Christopher J. Conselice, Megan Donahue, Brenda Frye, Seiji Fujimoto, Alaina Henry, Bethan L. James, Susan A. Kassin, Lisa Kewley, Rebecca L. Larson, Tod Lauer, David Law, Guillaume Mahler, Ramesh Mainali, Stephan McCandliss, David Nicholls, Norbert Pirzkal, Marc Postman, Jane R. Rigby, Russell Ryan, Peter Senchyna, Keren Sharon, Ikko Shimizu, Victoria Strait, Mengtao Tang, Michele Trenti, Anton Vikaeus, and Brian Welch

Subjects
Galaxies, High-redshift galaxies, Strong gravitational lensing, Galaxy clusters, Early universe, Astrophysics, QB460-466
Abstract

MACS0647–JD is a triply lensed z ∼ 11 galaxy originally discovered with the Hubble Space Telescope. The three lensed images are magnified by factors of ∼8, 5, and 2 to AB mag 25.1, 25.6, and 26.6 at 3.5 μ m. The brightest is over a magnitude brighter than other galaxies recently discovered at similar redshifts z > 10 with JWST. Here, we report new JWST imaging that clearly resolves MACS0647–JD as having two components that are either merging galaxies or stellar complexes within a single galaxy. The brighter larger component “A” is intrinsically very blue ( β ∼ −2.6 ± 0.1), likely due to very recent star formation and no dust, and is spatially extended with an effective radius ∼70 ± 24 pc. The smaller component “B” ( r ∼ 20 ${}_{-5}^{+8}\,$ pc) appears redder ( β ∼ −2 ± 0.2), likely because it is older (100–200 Myr) with mild dust extinction ( A _V ∼ 0.1 mag). With an estimated stellar mass ratio of roughly 2:1 and physical projected separation ∼400 pc, we may be witnessing a galaxy merger 430 million years after the Big Bang. We identify galaxies with similar colors in a high-redshift simulation, finding their star formation histories to be dissimilar, which is also suggested by the spectral energy distribution fitting, suggesting they formed further apart. We also identify a candidate companion galaxy “C” ∼3 kpc away, likely destined to merge with A and B. Upcoming JWST Near Infrared Spectrograph observations planned for 2023 January will deliver spectroscopic redshifts and more physical properties for these tiny magnified distant galaxies observed in the early universe.

Published
2023
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13. A dual-target herbicidal inhibitor of lysine biosynthesis

Author

Emily RR Mackie, Andrew S Barrow, Rebecca M Christoff, Belinda M Abbott, Anthony R Gendall, and Tatiana P Soares da Costa

Subjects
herbicide, weeds, lysine, diaminopimelate pathway, Medicine, Science, Biology (General), QH301-705.5
Abstract

Herbicides with novel modes of action are urgently needed to safeguard global agricultural industries against the damaging effects of herbicide-resistant weeds. We recently developed the first herbicidal inhibitors of lysine biosynthesis, which provided proof-of-concept for a promising novel herbicide target. In this study, we expanded upon our understanding of the mode of action of herbicidal lysine biosynthesis inhibitors. We previously postulated that these inhibitors may act as proherbicides. Here, we show this is not the case. We report an additional mode of action of these inhibitors, through their inhibition of a second lysine biosynthesis enzyme, and investigate the molecular determinants of inhibition. Furthermore, we extend our herbicidal activity analyses to include a weed species of global significance.

Published
2022
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14. Facilities maintenance covering Chevron s Barrow Island assets

Subjects
Chevron Australia Proprietary Ltd., Petroleum industry, Business, international
Abstract

Contract Awarded for Facilities maintenance covering Chevron s Barrow Island assets. About 500 people will be employed under the contract. The contract will cover operation and maintenance of support facilities [...]

Published
2015

15. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry

Author

Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, Alex Spyropoulos, John Eikelboom, Ramon Corbalan, Dayi Hu, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Sanjay Kakkar, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, D.Y. Hu, K.N. Chen, Y.S. Zhao, H.Q. Zhang, J.Z. Chen, S.P. Cao, D.W. Wang, Y.J. Yang, W.H. Li, Y.H. Yin, G.Z. Tao, P. Yang, Y.M. Chen, S.H. He, Ying Wang, Yong Wang, G.S. Fu, X. Li, T.G. Wu, X.S. Cheng, X.W. Yan, R.P. Zhao, M.S. Chen, L.G. Xiong, P. Chen, Y. Jiao, Y. Guo, L. Xue, F.Z. Wang, H. Li, Z.M. Yang, C.L. Bai, J. Chen, J.Y. Chen, X. Chen, S. Feng, Q.H. Fu, X.J. Gao, W.N. Guo, R.H. He, X.A. He, X.S. Hu, X.F. Huang, B. Li, J. Li, L. Li, Y.H. Li, T.T. Liu, W.L. Liu, Y.Y. Liu, Z.C. Lu, X.L. Luo, T.Y. Ma, J.Q. Peng, X. Sheng, X.J. Shi, Y.H. Sun, G. Tian, K. Wang, L. Wang, R.N. Wu, Q. Xie, R.Y. Xu, J.S. Yang, L.L. Yang, Q. Yang, Y. Ye, H.Y. Yu, J.H. Yu, T. Yu, H. Zhai, Q. Zhan, G.S. Zhang, Q. Zhang, R. Zhang, Y. Zhang, W.Y. Zheng, B. Zhou, Z.H. Zhou, X.Y. Zhu, S. Kakkar, J.P.S. Sawhney, P. Jadhav, R. Durgaprasad, A.G. Ravi Shankar, R.K. Rajput, K. Bhargava, R. Sarma, A. Srinivas, D. Roy, U.M. Nagamalesh, M. Chopda, R. Kishore, G. Kulkarni, P. Chandwani, R.A. Pothiwala, M. Padinhare Purayil, S. Shah, K. Chawla, V.A. Kothiwale, B. Raghuraman, G. Vijayaraghavan, V.M. Vijan, G. Bantwal, V. Bisne, A. Khan, J.B. Gupta, S. Kumar, D. Jain, S. Abraham, D. Adak, A. Barai, H. Begum, P. Bhattacharjee, M. Dargude, D. Davies, B. Deshpande, P. Dhakrao, V. Dhyani, S. Duhan, M. Earath, A. Ganatra, S. Giradkar, V. Jain, R. Karthikeyan, L. Kasala, S. Kaur, S. Krishnappa, A. Lawande, B. Lokesh, N. Madarkar, R. Meena, P. More, D. Naik, K. Prashanth, M. Rao, N.M. Rao, N. Sadhu, D. Shah, M. Sharma, P. Shiva, S. Singhal, S. Suresh, V. Vanajakshamma, S.G. Panse, Y. Koretsune, S. Kanamori, K. Yamamoto, K. Kumagai, Y. Katsuda, K. Sadamatsu, F. Toyota, Y. Mizuno, I. Misumi, H. Noguchi, S. Ando, T. Suetsugu, M. Minamoto, Hiroshi Oda, K. Shiraishi, S. Adachi, K. Chiba, H. Norita, M. Tsuruta, T. Koyanagi, H. Ando, T. Higashi, K. Okada, S. Azakami, S. Komaki, K. Kumeda, T. Murayama, J. Matsumura, Y. Oba, R. Sonoda, K. Goto, K. Minoda, Y. Haraguchi, H. Suefuji, H. Miyagi, H. Kato, Tadashi Nakamura, Tsugihiro Nakamura, H. Nandate, R. Zaitsu, Yoshihisa Fujiura, A. Yoshimura, H. Numata, J. Ogawa, H. Tatematsu, Y. Kamogawa, K. Murakami, Y. Wakasa, M. Yamasawa, H. Maekawa, S. Abe, H. Kihara, S. Tsunoda, Katsumi Saito, Kazuyuki Saito, T. Fudo, K. Obunai, H. Tachibana, I. Oba, T. Kuwahata, S. Higa, M. Gushiken, T. Eto, H. Yoshida, D. Ikeda, Yoshitake Fujiura, M. Ishizawa, M. Nakatsuka, K. Murata, C. Ogurusu, M. Shimoyama, M. Akutsu, I. Takamura, F. Hoshino, N. Yokota, T. Iwao, K. Tsuchida, M. Takeuchi, Y. Hatori, Y. Kitami, Yoichi Nakamura, R. Oyama, M. Ageta, Hiroyuki Oda, Y. Go, K. Mishima, T. Unoki, S. Morii, Yuhei Shiga, H. Sumi, T. Nagatomo, K. Sanno, K. Fujisawa, Y. Atsuchi, T. Nagoshi, T. Seto, T. Tabuchi, M. Kameko, K. Nii, K. Oshiro, H. Takezawa, S. Nagano, N. Miyamoto, M. Iwaki, Yuichiro Nakamura, M. Fujii, M. Okawa, Masahiko Abe, Masatake Abe, Mitsunori Abe, T. Saito, T. Mito, K. Nagao, J. Minami, T. Mita, I. Sakuma, T. Taguchi, S. Marusaki, H. Doi, M. Tanaka, T. Fujito, M. Matsuta, T. Kusumoto, S. Kakinoki, K. Ashida, N. Yoshizawa, J. Agata, O. Arasaki, M. Manita, M. Ikemura, S. Fukuoka, H. Murakami, S. Matsukawa, Y. Hata, T. Taniguchi, T. Ko, H. Kubo, M. Imamaki, M. Akiyama, M. Inagaki, H. Odakura, T. Ueda, Y. Katsube, A. Nakata, H. Watanabe, M. Techigawara, M. Igarashi, K. Taga, T. Kimura, S. Tomimoto, M. Shibuya, M. Nakano, K. Ito, T. Seo, S. Hiramitsu, H. Hosokawa, M. Hoshiai, M. Hibino, K. Miyagawa, Hajime Horie, N. Sugishita, Yukio Shiga, A. Soma, K. Neya, Tetsuro Yoshida, Tomoki Yoshida, M. Mizuguchi, M. Ishiguro, T. Minagawa, M. Wada, H. Mukawa, F. Okuda, S. Nagasaka, Y. Abe, Sen Adachi, Susumu Adachi, T. Adachi, K. Akahane, T. Amano, K. Aoki, T. Aoyama, H. Arai, S. Arima, T. Arino, H. Asano, T. Asano, J. Azuma, T. Baba, T. Betsuyaku, H. Chibana, H. Date, J. Doiuchi, Y. Emura, M. Endo, Y. Fujii, R. Fujiki, A. Fujisawa, Y. Fujisawa, T. Fukuda, T. Fukui, N. Furukawa, T. Furukawa, W. Furumoto, T. Goto, M. Hamaoka, N. Hanazono, K. Hasegawa, T. Hatsuno, Y. Hayashi, K. Higuchi, K. Hirasawa, H. Hirayama, M. Hirose, S. Hirota, M. Honda, Hideki Horie, T. Ido, O. Iiji, H. Ikeda, K. Ikeda, K. Ikeoka, M. Imaizumi, H. Inaba, T. Inoue, F. Iseki, A. Ishihara, N. Ishioka, N. Ito, T. Iwase, H. Kakuda, J. Kamata, H. Kanai, H. Kanda, M. Kaneko, H. Kano, T. Kasai, T. Kato, Y. Kato, Y. Kawada, K. Kawai, K. Kawakami, S. Kawakami, T. Kawamoto, S. Kawano, J. Kim, T. Kira, H. Kitazawa, H. Kitazumi, T. Kito, T. Kobayashi, T. Koeda, J. Kojima, H. Komatsu, I. Komatsu, Y. Koshibu, T. Kotani, T. Kozuka, Y. Kumai, T. Kumazaki, I. Maeda, K. Maeda, Y. Maruyama, S. Matsui, K. Matsushita, Y. Matsuura, K. Mineoi, H. Mitsuhashi, N. Miura, S. Miyaguchi, S. Miyajima, H. Miyamoto, A. Miyashita, S. Miyata, I. Mizuguchi, A. Mizuno, T. Mori, O. Moriai, K. Morishita, O. Murai, Sho Nagai, Shunichi Nagai, E. Nagata, H. Nagata, A. Nakagomi, S. Nakahara, M. Nakamura, R. Nakamura, N. Nakanishi, T. Nakayama, R. Nakazato, T. Nanke, J. Nariyama, Y. Niijima, H. Niinuma, Y. Nishida, Y. Nishihata, K. Nishino, H. Nishioka, K. Nishizawa, I. Niwa, K. Nomura, S. Nomura, M. Nozoe, T. Ogawa, N. Ohara, M. Okada, K. Okamoto, H. Okita, M. Okuyama, H. Ono, T. Ono, Y. Onuki Pearce, S. Oriso, A. Ota, E. Otaki, Y. Saito, H. Sakai, N. Sakamoto, Y. Sakamoto, Y. Samejima, Y. Sasagawa, H. Sasaguri, A. Sasaki, T. Sasaki, Kazuki Sato, Kiyoharu Sato, M. Sawano, S. Seki, Y. Sekine, Y. Seta, K. Sezaki, N. Shibata, Y. Shiina, H. Shimono, Y. Shimoyama, T. Shindo, H. Shinohara, R. Shinohe, T. Shinozuka, T. Shirai, T. Shiraiwa, Y. Shozawa, T. Suga, C. Sugimoto, Kazuo Suzuki, Keita Suzuki, Shu Suzuki, Shunji Suzuki, Susumu Suzuki, Y. Suzuki, M. Tada, A. Taguchi, T. Takagi, Y. Takagi, K. Takahashi, S. Takahashi, H. Takai, C. Takanaka, S. Take, H. Takeda, K. Takei, K. Takenaka, T. Tana, G. Tanabe, K. Taya, H. Teragawa, S. Tohyo, S. Toru, Y. Tsuchiya, T. Tsuji, K. Tsuzaki, H. Uchiyama, O. Ueda, Y. Ueyama, N. Wakaki, T. Wakiyama, T. Washizuka, M. Watanabe, T. Yamada, T. Yamagishi, H. Yamaguchi, Kenichi Yamamoto, Kentaro Yamamoto, Kunihiko Yamamoto, T. Yamamoto, M. Yamaura, M. Yamazoe, K. Yasui, Y. Yokoyama, K. Yoshida, T.W. Lim, C.K. Ching, C.G. Foo, J.H. Chow, D.D. Chen, F.R. Jaufeerally, Y.M. Lee, G. Lim, W.T. Lim, S. Thng, S.Y. Yap, C. Yeo, S. Oh, H.N. Pak, J.-B. Kim, J.H. Kim, S.-W. Jang, D.H. Kim, D.R. Ryu, S.W. Park, D.-K. Kim, D.J. Choi, Y.S. Oh, M.-C. Cho, S.-H. Kim, H.-K. Jeon, D.-G. Shin, J.S. Park, H.K. Park, S.-J. Han, J.H. Sung, J.-G. Cho, G.-B. Nam, Y.K. On, H.E. Lim, J.J. Kwak, T.-J. Cha, T.J. Hong, S.H. Park, J.H. Yoon, N.-H. Kim, K.-S. Kim, B.C. Jung, G.-S. Hwang, C.-J. Kim, D.B. Kim, J.J. Ahn, H.J. An, H. Bae, A.L. Baek, W.J. Chi, E.A. Choi, E.H. Choi, H.K. Choi, H.S. Choi, S. Han, E.S. Heo, K.O. Her, S.W. Hwang, E.M. Jang, H.-S. Jang, S. Jang, H.-G. Jeon, S.R. Jeon, Y.R. Jeon, H.K. Jeong, I.-A. Jung, Hyeon Jeong Kim, Hyun Ju Kim, Ji Seon Kim, Jung Sook Kim, J.A. Kim, K.T. Kim, M.S. Kim, Sang Hee Kim, Sang Hyun Kim, Y.-I. Kim, C.S. Lee, E.H. Lee, G.H. Lee, H.Y. Lee, H.-Y. Lee, K.H. Lee, K.R. Lee, M.S. Lee, M.-Y. Lee, R.W. Lee, S.E. Lee, S.H. Lee, S. Lee, W.Y. Lee, I.K. Noh, A.R. Park, B.R. Park, H.N. Park, J.H. Park, M. Park, Y. Park, S.-Y. Seo, J. Shim, J.H. Sim, Y.M. Sohn, W.S. Son, Y.S. Son, H.J. Song, H.K. Wi, J.J. Woo, S. Ye, K.H. Yim, K.M. Yoo, E.J. Yoon, S.Y. Yun, P. Angchaisuksiri, S. Chawanadelert, P. Mongkolwongroj, K. Kanokphatcharakun, S. Cheewatanakornkul, T. Laksomya, S. Pattanaprichakul, T. Chantrarat, S. Rungaramsin, S. Silaruks, W. Wongcharoen, K. Siriwattana, K. Likittanasombat, P. Katekangplu, W. Boonyapisit, D. Cholsaringkarl, B. Chatlaong, P. Chattranukulchai, Y. Santanakorn, P. Hutayanon, P. Khunrong, T. Bunyapipat, S. Jai-Aue, P. Kaewsuwanna, P. Bamungpong, S. Gunaparn, S. Hongsuppinyo, R. Inphontan, R. Khattaroek, K. Khunkong, U. Kitmapawanont, C. Kongsin, B. Naratreekoon, S. Ninwaranon, J. Phangyota, A. Phrommintikul, P. Phunpinyosak, K. Pongmorakot, S. Poomiphol, N. Pornnimitthum, S. Pumprueg, S. Ratchasikaew, K. Sanit, K. Sawanyawisuth, B. Silaruks, R. Sirichai, A. Sriwichian, W. Suebjaksing, P. Sukklad, T. Suttana, A. Tangsirira, O. Thangpet, W. Tiyanon, Y. Vorasettakarnkij, T. Wisaratapong, W. Wongtheptien, A. Wutthimanop, S. Yawila, A. Oto, A. Altun, I. Ozdogru, K. Ozdemir, O. Yilmaz, A. Aydinlar, M.B. Yilmaz, E. Yeter, Z. Ongen, M. Cayli, H. Pekdemir, M. Ozdemir, M. Sucu, T. Sayin, M. Demir, H. 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Sterry, T. Wong, M. Boon, R. Bunney, R. Haria-Shah, R.T. Baron, S. Davies, T. Schatzberger, N. Hargreaves, T. Stephenson, H. Choi, R. Batson, L. Lucraft, T. Myhill, S. Estifano, D. Geatch, J. Wilkinson, R. Veale, K. Forshaw, T. Davies, K. Zaman, P. Vinson, C. Liley, M. Bandrapalli, P. McGinty, R. Wastling, P. McEleny, A. Beattie, P. Cooke, M. Wong, J. Gunasegaram, M. Pugsley, S. Ahmad, C. A'Court, J. Ayers, J. Bennett, S. Cartwright, S. Dobson, C. Dooldeniya, A. Flynn, R. Fox, J. Goram, A. Halpin, A. Hay, P. Jacobs, L. Jeffers, L. Lomax, I. Munro, R. Muvva, M. Nadaph, K. Powell, S. Randfield, D. Redpath, R. Reed, M. Rickenbach, G. Rogers, P.B. Saunders, C. Seamark, J. Shewring, P. Simmons, H. Simper, H. Stoddart, A. Sword, N. Thomas, A. Thomson, H. Gibbs, A. Blenkhorn, B. Singh, W. Van Gaal, W. Abhayaratna, R. Lehman, P. Roberts-Thomson, J. Kilian, D. Coulshed, A. Catanchin, D. Colquhoun, H. Kiat, D. Eccleston, J. French, L. Zimmett, B. Ayres, T. Phan, P. Blombery, D. Crimmins, D. 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Nathani, M. Ibrahim, E.M. Esheiba, R. Singh, A. Naguib, M. Abu-Mahfouz, M. Al Omairi, A. Al Naeemi, R. Maruthanayagam, N. Bazargani, A. Wassef, R. Gupta, M. Khan, B. Subbaraman, A. Abdul, A. Al Mulla, S. El Bardisy, P. Haridas, S. Jadhav, K. Magdaluyo, M. Makdad, I. Maqsood, R. Mohamed, N. Sharma, R. Sharma, M. Thanzeel, S.Z. Goldhaber, R. Canosa, P. Rama, E. Blumberg, J. Garcia, P. Mullen, V. Wilson, A. Quick, K. Ferrick, W.M. Kutayli, M. Cox, M. Franco, S. Falkowski, R. Mendelson, M. Williams, S. Miller, S. Beach, A. Alfieri, T. Gutowski, I. Haque, R. Reddy, W. Ahmed, P. Delafontaine, D. Diercks, D. Theodoro, K. Remmel, M. Alberts, R. Ison, H. Noveck, P. Duffy, S. Pitta, D. Nishijima, C. Treasure, N. Asafu-Adjaye, K. Ball, M. Bartlett, M. Bentley, S. Bowers, A. Brown, A. Browne, J. Cameron-Watts, M. Canova, D. Cassidy, K. Cervellione, S. Congal, J. DePauw, A. Dickerson, M. Eley, L. Evans, S. Felpel, K. Ferdinand, D. Fielder, P. Gentry, A. Haideri, F. Hakimi, T. Harbour, E. Hartranft, B. Hawkins, M. Headlee, L. Henson, C. Herrick, T. Hicks, S. Jasinski, A. Jones, L. Jones, P. Jones, S. Karl, M. Keeling, J. Kerr, P. Knowles, J. Langdon, M. Lay, J.A. Lee, T. Lincoln, E. Malone, A. Merliss, D. Merritt, J. Minardo, B. Mooso, C. Orosco, V. Palumbo, M. Parker, T. Parrott, S. Paserchia, G. Pearl, J. Peterson, N. Pickelsimer, T. Purcell, J. Raynor, S. Raziano, C. Richard, T. Richardson, C. Robertson, A. Sage, T. Sanghera, P. Shaw, J. Shoemaker, K. Smith, B. Stephanie, A. Thatcher, H. Theobald, N. Thompson, L. Treasure, T. Tripti, C. Verdi, and V. Worthy

Subjects
Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P

Published
2018
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16. Sustainable Syntheses of (−)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site

Author

Christopher J. Smedley, Paul A. Stanley, Mohannad E. Qazzaz, Andrea E. Prota, Natacha Olieric, Hilary Collins, Harry Eastman, Andrew S. Barrow, Kuan-Hon Lim, Toh-Seok Kam, Brian J. Smith, Hendrika M. Duivenvoorden, Belinda S. Parker, Tracey D. Bradshaw, Michel O. Steinmetz, and John E. Moses

Subjects
Medicine, Science
Abstract

Abstract The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly disrupted due to the inclusion of T. corymbosa on the endangered list of threatened species by the International Union for Conservation of Nature. This report describes the asymmetric syntheses of (−)-jerantinines A and E from sustainably sourced (−)-tabersonine, using a straight-forward and robust biomimetic approach. Biological investigations of synthetic (−)-jerantinine A, along with molecular modelling and X-ray crystallography studies of the tubulin—(−)-jerantinine B acetate complex, advocate an anticancer mode of action of the jerantinines operating via microtubule disruption resulting from binding at the colchicine site. This work lays the foundation for accessing useful quantities of enantiomerically pure jerantinine alkaloids for future development.

Published
2018
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17. Biosynthesis of uridine diphosphate N ‐Acetylglucosamine: An underexploited pathway in the search for novel antibiotics?

Author

Jessica A. Wyllie, Mirrin V. McKay, Andrew S. Barrow, and Tatiana P. Soares da Costa

Subjects
Uridine Diphosphate N-Acetylglucosamine, Clinical Biochemistry, Genetics, Peptidoglycan, Cell Biology, Molecular Biology, Biochemistry, Anti-Bacterial Agents
Abstract

Although the prevalence of antibiotic resistance is increasing at an alarming rate, there are a dwindling number of effective antibiotics available. Thus, the development of novel antibacterial agents should be of utmost importance. Peptidoglycan biosynthesis has been and is still an attractive source for antibiotic targets; however, there are several components that remain underexploited. In this review, we examine the enzymes involved in the biosynthesis of one such component, UDP-N-acetylglucosamine, an essential building block and precursor of bacterial peptidoglycan. Furthermore, given the presence of a similar biosynthesis pathway in eukaryotes, we discuss the current knowledge on the differences and similarities between the bacterial and eukaryotic enzymes. Finally, this review also summarises the recent advances made in the development of inhibitors targeting the bacterial enzymes.

Published
2022

20. Carbene footprinting accurately maps binding sites in protein–ligand and protein–protein interactions

Author

Lucio Manzi, Andrew S. Barrow, Daniel Scott, Robert Layfield, Timothy G. Wright, John E. Moses, and Neil J. Oldham

Subjects
Science
Abstract

Mapping protein-ligand interactions is fundamental to advance the understanding of cellular processes and to develop drug discovery strategies. Here, the authors present a photo-activated probe that allows highly efficient labelling and identification of protein binding sites using mass spectrometry.

Published
2016
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21. Lifetime movement history is associated with variable growth of a potamodromous freshwater fish

Author

Zeb Tonkin, Brenton P. Zampatti, Joshua S. Barrow, Jason D. Thiem, John D. Koehn, Jian D. L. Yen, Arron Strawbridge, and John R. Morrongiello

Subjects
Fish migration, education.field_of_study, Perch, biology, Movement, Population, Fresh Water, biology.organism_classification, Perciformes, Otolithic Membrane, medicine.anatomical_structure, Perches, Freshwater fish, medicine, Animals, Juvenile, Biological dispersal, Animal Science and Zoology, Macquaria ambigua, education, Ecology, Evolution, Behavior and Systematics, Demography, Otolith
Abstract

Directional or stabilising selection should drive the expression of a dominant movement phenotype within a population. Widespread persistence of multiple movement phenotypes within wild populations, however, suggests that individuals that move (movers) and those that do not (residents) can have commensurate performance. The costs and benefits of mover and resident phenotypes remain poorly understood. Here, we explored how the presence and timing of movements are correlated with annual somatic growth rates, a useful proxy for performance because it is easily measured and rapidly reflects environmental changes. We used otolith growth measurements and stable isotope analyses to recreate growth and among-reach movement histories of a partially migrating, long-lived freshwater fish, golden perch Macquaria ambigua. We compared the association between movement and growth at two temporal scales: (a) short-term (annual) differences in growth, in the years preceding, during or following movement; and (b) long-term (lifetime) differences in growth. Overall, 59% of individuals performed at least one among-reach movement, with these individuals subsequently more likely to move repeatedly throughout their lives. Movers grew faster than residents, with this difference most pronounced in the juvenile and early adult stages, when most movements occurred. Annual growth did not, however, change immediately prior to or following a specific movement event. Among-individual variation in growth was initially higher for residents than for movers but decreased with age, at a faster rate for residents than for movers, such that levels conformed after 5 years of age. Our results indicate that lifetime movement is linked to faster growth in the early years of a fish's life. These faster growing movers are likely to be larger at a given age, leading to numerous potential benefits. However, the persistence of resident phenotypes suggests that there is likely a cost-benefit trade-off to moving. The presence of multiple movement phenotypes may contribute to the resilience of populations by buffering against naturally and anthropogenically exacerbated environmental variability.

Published
2021

25. Paediatric dental A&E service during the COVID-19 pandemic in the Greater London area

Author

Jed Y. J. Lee, S Barrow, E C Sheehy, R Sanghvi, N Patel, A Viswanathan, A Cant, J Layton, Nabina Bhujel, and M Deseta

Subjects
Dental practice, Service (business), Government, Coronavirus disease 2019 (COVID-19), business.industry, Dental emergency, 030206 dentistry, Paediatric dentistry, medicine.disease, Dental care, stomatognathic diseases, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, Pediatrics, Perinatology and Child Health, Pandemic, Medicine, Dentistry (miscellaneous), 030212 general & internal medicine, Medical emergency, medicine.symptom, business
Abstract

The UK government introduced a nationwide lockdown on the 23rd March 2020 to prevent the spread of COVID-19. All elective hospital and dental practice assessments and procedures were mandated to stop. Key hospital dental workers were required to work, and Guy’s and St Thomas’ NHS Foundation Trust became a designated Urgent Dental Care Centre (UDC) for the greater London area. The paediatric dental emergency walk-in service was suspended and replaced with a telephone triage system and evaluation of digital images sent by parents/carers when needed. The aim of this paper is to describe the emergency service provided by staff in the department of Paediatric Dentistry at St Thomas’ Hospital during the first lockdown. A prospective service evaluation of the modified paediatric dental emergency service was carried out between 25th March and 29th May 2020. Four-hundred and sixty-four patients accessed the paediatric dental emergency service via telephone during the service evaluation period. Of these, 192 (41%) had dental pain, 121 (26%) had pain and swelling of dental origin, and 89 (19%) had trauma. Remote telephone consultations and digital photographs were useful to screen emergency paediatric dental patients, but lack of face-to-face consultations with radiographic assessment and access to general anaesthetic services were major limiting factors.

Published
2021

26. Aminium cation-radical catalysed selective hydration of (E)-aryl enynes

Author

John E. Moses, Andrew S. Barrow, Marie-Claire Giel, William Lewis, and Christopher J. Smedley

Subjects
Tris, chemistry.chemical_classification, Natural product, 010405 organic chemistry, Aryl, Markovnikov's rule, Metals and Alloys, Alkyne, Salt (chemistry), General Chemistry, 010402 general chemistry, Triple bond, 01 natural sciences, Medicinal chemistry, Catalysis, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, chemistry, Materials Chemistry, Ceramics and Composites
Abstract

The hydration of carbon–carbon triple bonds is an important and atom economic synthetic transformation. Herein, we report a mild and selective method for the catalytic Markovnikov hydration of (E)-aryl enynes to the corresponding enones, mediated through the bench-stable aminium salt, tris(4-bromophenyl)ammoniumyl hexachloroantimonate (TBPA). The chemoselective and diastereoselective method proceeds under neutral metal-free conditions, delivering excellent product yields from terminal and internal alkyne units. The synthesis of biologically important (E)-3-styrylisocoumarins, including a formal synthesis of the natural product achlisocoumarin III, demonstrates the utility of this novel transformation.

Published
2021

27. Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs

Author

Andrew S. Barrow, Alessandra Ottonello, K. Barry Sharpless, Dennis W. Wolan, Gencheng Li, Yunfei Cheng, Marie-Claire Giel, Seiya Kitamura, John E. Moses, Christopher J. Smedley, and Timothy L Gialelis

Subjects
Cycloaddition Reaction, Molecular Structure, Bicyclic molecule, 010405 organic chemistry, Chemistry, General Chemistry, Sulfinic Acids, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Article, Catalysis, 0104 chemical sciences, Functional importance, Click chemistry, Click Chemistry, Pharmacophore, Divergent synthesis, Sulfonyl fluoride
Abstract

Diversity Oriented Clicking (DOC) is a unified click-approach for the modular synthesis of lead-like structures through application of the wide family of click transformations. DOC evolved from the concept of achieving "diversity with ease", by combining classic C-C π-bond click chemistry with recent developments in connective SuFEx-technologies. We showcase 2-Substituted-Alkynyl-1-Sulfonyl Fluorides (SASFs) as a new class of connective hub in concert with a diverse selection of click-cycloaddition processes. Through the selective DOC of SASFs with a range of dipoles and cyclic dienes, we report a diverse click-library of 173 unique functional molecules in minimal synthetic steps. The SuFExable library comprises 10 discrete heterocyclic core structures derived from 1,3- and 1,5-dipoles; while reaction with cyclic dienes yields several three-dimensional bicyclic Diels-Alder adducts. Growing the library to 278 discrete compounds through late-stage modification was made possible through SuFEx click derivatization of the pendant sulfonyl fluoride group in 96 well-plates-demonstrating the versatility of the DOC approach for the rapid synthesis of diverse functional structures. Screening for function against MRSA (USA300) revealed several lead hits with improved activity over methicillin.

Published
2020

28. Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs

Author

Christopher J. Smedley, Gencheng Li, Andrew S. Barrow, Timothy L. Gialelis, Marie‐Claire Giel, Alessandra Ottonello, Yunfei Cheng, Seiya Kitamura, Dennis W. Wolan, K. Barry Sharpless, and John E. Moses

Subjects
010405 organic chemistry, General Medicine, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences
Published
2020

29. From bacteria to plants: a repurposing strategy in the pursuit for novel herbicides

Author

Emily R. R. Mackie, Andrew S. Barrow, Marie-Claire Giel, Mark D. Hulett, Anthony R. Gendall, Santosh Panjikar, and Tatiana P. Soares da Costa

Subjects
fungi, food and beverages
Abstract

Herbicide resistance represents one of the biggest threats to our natural environment and agricultural sector. Thus, new herbicides are urgently needed to tackle the rise in herbicideresistant weeds. Here, we employed a novel strategy to repurpose a ‘failed’ antibiotic into a new and target-specific herbicidal compound. Specifically, we identified an inhibitor of bacterial dihydrodipicolinate reductase (DHDPR), an enzyme involved in lysine biosynthesis in plants and bacteria, that exhibited no antibacterial activity but severely attenuated germination of the plant Arabidopsis thaliana. We confirmed that the inhibitor targets plant DHDPR orthologues in vitro, and exhibits no toxic effects against human cell lines. A series of analogues were then synthesised with improved efficacy in germination assays and against soil-grown A. thaliana plants. We also showed that our lead compound is the first lysine biosynthesis inhibitor with herbicidal activity against a weed species, providing proof-of-concept that DHDPR inhibition may represent a much-needed new herbicide mode of action. Furthermore, this study exemplifies the untapped potential of repurposing ‘failed’ antibiotic scaffolds to fast-track the development of herbicide candidates targeting the respective plant enzymes to combat the global rise in herbicide-resistant weeds.

Published
2022

30. Accelerated SuFEx Click Chemistry For Modular Synthesis**

Author

Andrew S Barrow, Joshua A Homer, John E. Moses, Christopher J. Smedley, Rebecca A Koelln, and Timothy L Gialelis

Subjects
chemistry.chemical_classification, Molecular Structure, Sulfur Compounds, Aryl, Chemical biology, General Chemistry, General Medicine, Guanidines, Combinatorial chemistry, Article, Catalysis, Fluorides, chemistry.chemical_compound, chemistry, Alcohols, Reagent, Click chemistry, Click Chemistry, Organic synthesis, Guanidine, Alkyl
Abstract

SuFEx click chemistry is a powerful method designed for the selective, rapid and modular synthesis of functional molecules. Classical SuFEx reactions form stable S-O linkages upon exchange of S-F bonds with aryl silyl-ether substrates, and while near-perfect in their outcome, are sometimes disadvantaged by relatively high catalyst loadings and prolonged reaction times. We herein report the development of 'Accelerated SuFEx Click Chemistry' (ASCC), an improved SuFEx method for the efficient and catalytic coupling of aryl and alkyl alcohols with a range of SuFExable hubs. We demonstrate Barton's hindered guanidine base (2- tert -butyl-1,1,3,3-tetramethylguanidine; BTMG) as a superb SuFEx catalyst that, when used in synergy with silicon additive hexamethyldisilazane (HMDS), yields stable S-O bond linkages in a single step; often within minutes. The powerful combination of BTMG and HMDS reagents allows for catalyst loadings as low as 1.0 mol% and, in congruence with click-principles, provides a scalable method that is safe, efficient, and practical for modular synthesis. ASSC expands the number of accessible SuFEx products and will find significant application in organic synthesis, medicinal chemistry, chemical biology, and materials science .

Published
2021

31. TopoRoot+: computing whorl and soil line traits of field-excavated maize roots from CT imaging.

Author

Ju, Yiwen, Liu, Alexander E., Oestreich, Kenan, Wang, Tina, Topp, Christopher N., and Ju, Tao

Subjects
THREE-dimensional imaging, COMPUTED tomography, CORN, COMPUTER software testing, COMPUTER graphics
Abstract

Background: The use of 3D imaging techniques, such as X-ray CT, in root phenotyping has become more widespread in recent years. However, due to the complexity of the root structure, analyzing the resulting 3D volumes to obtain detailed architectural root traits remains a challenging computational problem. When it comes to image-based phenotyping of excavated maize root crowns, two types of root features that are notably missing from existing methods are the whorls and soil line. Whorls refer to the distinct areas located at the base of each stem node from which roots sprout in a circular pattern (Liu S, Barrow CS, Hanlon M, Lynch JP, Bucksch A. Dirt/3D: 3D root phenotyping for field-grown maize (zea mays). Plant Physiol. 2021;187(2):739–57. https://doi.org/10.1093/plphys/kiab311.). The soil line is where the root stem meets the ground. Knowledge of these features would give biologists deeper insights into the root system architecture (RSA) and the below- and above-ground root properties. Results: We developed TopoRoot+, a computational pipeline that produces architectural traits from 3D X-ray CT volumes of excavated maize root crowns. Building upon the TopoRoot software (Zeng D, Li M, Jiang N, Ju Y, Schreiber H, Chambers E, et al. Toporoot: A method for computing hierarchy and fine-grained traits of maize roots from 3D imaging. Plant Methods. 2021;17(1). https://doi.org/10.1186/s13007-021-00829-z.) for computing fine-grained root traits, TopoRoot + adds the capability to detect whorls, identify nodal roots at each whorl, and compute the soil line location. The new algorithms in TopoRoot + offer an additional set of fine-grained traits beyond those provided by TopoRoot. The addition includes internode distances, root traits at every hierarchy level associated with a whorl, and root traits specific to above or below the ground. TopoRoot + is validated on a diverse collection of field-grown maize root crowns consisting of nine genotypes and spanning across three years. TopoRoot + runs in minutes for a typical volume size of on a desktop workstation. Our software and test dataset are freely distributed on Github. Conclusions: TopoRoot + advances the state-of-the-art in image-based phenotyping of excavated maize root crowns by offering more detailed architectural traits related to whorls and soil lines. The efficiency of TopoRoot + makes it well-suited for high-throughput image-based root phenotyping. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Aminium cation-radical catalysed selective hydration of (

Author

Marie-Claire, Giel, Andrew S, Barrow, Christopher J, Smedley, William, Lewis, and John E, Moses

Subjects
Article
Abstract

The hydration of carbon-carbon triple bonds is an important and atom economic synthetic transformation. Herein, we report a mild and selective method for the catalytic Markovnikov hydration of (E)-aryl enynes to the corresponding enones, mediated through the bench-stable aminium salt, tris(4-bromophenyl)ammoniumyl hexachloroantimonate (TBPA). The chemoselective and diastereoselective method proceeds under neutral metal-free conditions, delivering excellent product yields from terminal and internal alkyne units. The synthesis of biologically important (E)-3-styrylisocoumarins, including a formal synthesis of the natural product achlisocoumarin III, demonstrates the utility of this novel transformation.

Published
2021

33. The growing applications of SuFEx click chemistry

Author

Jiajia Dong, Suhua Li, Andrew S. Barrow, Qinheng Zheng, John E. Moses, and Christopher J. Smedley

Subjects
Sulfur fluoride, Functional importance, Drug discovery, Chemistry, Click chemistry, Nanotechnology, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 0210 nano-technology, 01 natural sciences, 0104 chemical sciences
Abstract

SuFEx (Sulfur Fluoride Exchange) is a modular, next generation family of click reactions, geared towards the rapid and reliable assembly of functional molecules. This review discusses the growing number of applications of SuFEx, which can be found in nearly all areas of modern chemistry; from drug discovery to materials science.

Published
2019

34. Paediatric dental-oral medicine clinic: management during COVID 19

Author

R. Cook, Esther Hullah, R. Sanghvi, S. Barrow, D. Siddik, and M. De Souza

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), RD1-811, Recurrent aphthous stomatitis, 01 natural sciences, Systemic therapy, teledentistry, paediatric dentistry, 03 medical and health sciences, Alternative assessment, 0302 clinical medicine, Patient satisfaction, medicine, Dentistry (miscellaneous), Medical history, 030212 general & internal medicine, 0101 mathematics, Teledentistry, business.industry, 010102 general mathematics, RK1-715, covid-19, Family medicine, Dentistry, Periodontics, Surgery, Oral Surgery, business, Oral medicine
Abstract

Introduction: Minimising spread of the COVID-19 infection through reducing face-to-face consults is essential. In doing so, alternative assessment and communication methods for management of patients with oral conditions should be considered. Material and methods: Patients on the waiting list for the joint oral medicine-paediatric dental clinic between March and June 2020 were prioritised based on a criteria including relevant medical history, diagnosis and clinical need and current management − monitoring, topical therapy or systemic therapy. A telephone consult method was chosen to assess and follow up patients and a parental satisfaction questionnaire was conducted following telephone consult. Results: Recurrent aphthous stomatitis (RAS) was the most common diagnosis of patients reviewed on the telephone clinic. Overall, the patient satisfaction questionnaire revealed that 100% of respondents would prefer a telephone consult during COVID-19 rather than face-to-face appointments. 74% opted for a video consult in preference to a telephone consult. Conclusion: This service evaluation has found telephone consults to be a valuable alternative to face-to-face consults in the management of patients with chronic oral mucosal diseases. Telephone consultations have high parental satisfaction and are an effective, convenient method to assess and follow up patients whilst maintaining their safety during the COVID-19 pandemic.

Published
2021

35. Paediatric dental AE service during the COVID-19 pandemic in the Greater London area

Author

N, Patel, A, Viswanathan, J, Lee, S, Barrow, A, Cant, R, Sanghvi, M, Deseta, J, Layton, N, Bhujel, and E C, Sheehy

Subjects
SARS-CoV-2, Communicable Disease Control, London, COVID-19, Humans, Prospective Studies, Child, Emergency Service, Hospital, Pandemics, Letter to the Editor
Abstract

The UK government introduced a nationwide lockdown on the 23rd March 2020 to prevent the spread of COVID-19. All elective hospital and dental practice assessments and procedures were mandated to stop. Key hospital dental workers were required to work, and Guy's and St Thomas' NHS Foundation Trust became a designated Urgent Dental Care Centre (UDC) for the greater London area. The paediatric dental emergency walk-in service was suspended and replaced with a telephone triage system and evaluation of digital images sent by parents/carers when needed. The aim of this paper is to describe the emergency service provided by staff in the department of Paediatric Dentistry at St Thomas' Hospital during the first lockdown.A prospective service evaluation of the modified paediatric dental emergency service was carried out between 25th March and 29th May 2020.Four-hundred and sixty-four patients accessed the paediatric dental emergency service via telephone during the service evaluation period. Of these, 192 (41%) had dental pain, 121 (26%) had pain and swelling of dental origin, and 89 (19%) had trauma.Remote telephone consultations and digital photographs were useful to screen emergency paediatric dental patients, but lack of face-to-face consultations with radiographic assessment and access to general anaesthetic services were major limiting factors.

Published
2020

37. The Lyman Continuum Escape Survey: Connecting Time-Dependent [OIII] and [OII] Line Emission with Lyman Continuum Escape Fraction in Simulations of Galaxy Formation

Author

Kirk S. S. Barrow, A. Saxena, Kimihiko Nakajima, Mengtao Tang, Brant Robertson, Richard S. Ellis, and Daniel P. Stark

Subjects
Physics, 010308 nuclear & particles physics, Continuum (design consultancy), Doubly ionized oxygen, FOS: Physical sciences, Astronomy and Astrophysics, Fraction (chemistry), Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Astrophysics - Astrophysics of Galaxies, High time-resolution astrophysics, Emission nebula, 13. Climate action, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), 0103 physical sciences, Galaxy formation and evolution, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Line (formation)
Abstract

Escaping Lyman continuum photons from galaxies likely reionized the intergalactic medium at redshifts $z\gtrsim6$. However, the Lyman continuum is not directly observable at these redshifts and secondary indicators of Lyman continuum escape must be used to estimate the budget of ionizing photons. Observationally, at redshifts $z\sim2-3$ where the Lyman continuum is observationally accessible, surveys have established that many objects that show appreciable Lyman continuum escape fractions $f_{esc}$ also show enhanced [OIII]/[OII] (O$_{32}$) emission line ratios. Here, we use radiative transfer analyses of cosmological zoom-in simulations of galaxy formation to study the physical connection between $f_{esc}$ and O$_{32}$. Like the observations, we find that the largest $f_{esc}$ values occur at elevated O$_{32}\sim3-10$ and that the combination of high $f_{esc}$ and low O$_{32}$ is extremely rare. While high $f_{esc}$ and O$_{32}$ often are observable concurrently, the timescales of the physical origin for the processes are very different. Large O$_{32}$ values fluctuate on short ($\sim$1 Myr) timescales during the Wolf-Rayet-powered phase after the formation of star clusters, while channels of low absorption are established over tens of megayears by collections of supernovae. We find that while there is no direct causal relation between $f_{esc}$ and O$_{32}$, high $f_{esc}$ most often occurs after continuous input from star formation-related feedback events that have corresponding excursions to large O$_{32}$ emission. These calculations are in agreement with interpretations of observations that large $f_{esc}$ tends to occur when O$_{32}$ is large, but large O$_{32}$ does not necessarily imply efficient Lyman continuum escape., Comment: 12 pages, 5 figures, submitted to ApJL on September 15, 2020

Published
2020
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38. Observational signatures of massive black hole formation in the early Universe

Author

Kirk S. S. Barrow, John H. Wise, and Aycin Aykutalp

Subjects
Physics, Supermassive black hole, 010308 nuclear & particles physics, Star formation, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astronomy and Astrophysics, Quasar, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Astrophysics - Astrophysics of Galaxies, 01 natural sciences, Accretion (astrophysics), Redshift, Galaxy, Black hole, General Relativity and Quantum Cosmology, Spitzer Space Telescope, Astrophysics of Galaxies (astro-ph.GA), 0103 physical sciences, Astrophysics::Earth and Planetary Astrophysics, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics
Abstract

Space telescope observations of massive black holes during their formation may be key to understanding the origin of supermassive black holes and high-redshift quasars. To create diagnostics for their detection and confirmation, we study a simulation of a nascent massive, so-called direct-collapse, black hole that induces a wave of nearby massive metal-free star formation, unique to this seeding scenario and to very high redshifts. Here we describe a series of distinct colors and emission line strengths, dependent on the relative strength of star formation and black hole accretion. We predict that the forthcoming James Webb Space Telescope might be able to detect and distinguish a young galaxy that hosts a direct-collapse black hole in this configuration at redshift 15 with as little as a 20,000-second total exposure time across four filters, critical for constraining supermassive black hole seeding mechanisms and early growth rates. We also find that a massive seed black hole produces strong, H$_2$-dissociating Lyman-Werner radiation., Comment: As submitted on May 30th, 2018. Published in Nature Astronomy on September 10th, 2018

Published
2018

39. Dynamic Nuclear Polarisation Enhanced Solid-State Nuclear Magnetic Resonance Studies of Surface Modification of γ-Alumina

Author

Subhradip Paul, Marco Mais, Jeremy J. Titman, and Nathan S. Barrow

Subjects
Materials science, Spin polarization, Process Chemistry and Technology, Dynamic nuclear polarisation, Metals and Alloys, 02 engineering and technology, Nuclear magnetic resonance spectroscopy, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Catalysis, NMR spectra database, Unpaired electron, Solid-state nuclear magnetic resonance, Electrochemistry, Surface modification, Physical chemistry, 0210 nano-technology
Abstract

Dynamic nuclear polarization (DNP) gives large (>100-fold) signal enhancements in solid-state NMR spectra via the transfer of spin polarization from unpaired electrons from radicals implanted in the sample. This means that the detailed information about local molecular environment available for bulk samples from solid-state NMR spectroscopy can now be obtained for dilute species, such as sites on the surfaces of catalysts and catalyst supports. In this paper we describe a DNP-enhanced solid-state NMR study of the widely used catalyst gamma-alumina which is often modified at the surface by the incorporation of alkaline earth oxides in order to control the availability of catalytically active penta-coordinate surface Al sites. DNP-enhanced 27Al solid-state NMR allows surface sites in gamma-alumina to be observed and their 27Al NMR parameters measured. In addition changes in the availability of different surface sites can be detected after incorporation of BaO.

Published
2018

40. Accessibility and Location of Acid Sites in Zeolites as Probed by Fourier Transform Infrared Spectroscopy and Magic Angle Spinning Nuclear Magnetic Resonance

Author

Nathan S. Barrow, Cátia Freitas, and Vladimir L. Zholobenko

Subjects
Materials science, Process Chemistry and Technology, Metals and Alloys, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Nuclear magnetic resonance, Electrochemistry, Magic angle spinning, QD, Fourier transform infrared spectroscopy, 0210 nano-technology
Abstract

The understanding of location and accessibility of zeolite acid sites is a key issue in heterogeneous catalysis. This paper provides a brief overview of Fourier transform infrared (FTIR) spectroscopy and nuclear magnetic resonance (NMR) characterisation of acidity in zeolites based on the application of test molecules with a diverse range of basicity and kinetic diameters. Many zeolites, including ZSM-5 and BEA, have been characterised by monitoring the interaction between the zeolite acid sites and test molecules, such as 1,3,5-triisopropylbenzene, pyridine and alkylpyridines, to probe the location, accessibility and strength of the Bronsted acid sites. 1,3,5-triisopropylbenzene can be used to distinguish Bronsted acid sites located on the external and internal surface in most medium and large pore channel zeolites. Bronsted acid sites on the external surface of medium pore zeolites can also be quantified using 2,6-di-tert-butyl-pyridine and 2,4,6-trimethylpyridine. It is concluded that using a combination of probe molecules, including co-adsorption experiments, affords differentiation between acid sites located in channels and cavities of different sizes and on the external and internal surfaces of various zeolitic structures.

Published
2018

41. Environmental drivers of growth and predicted effects of climate change on a commercially important fish, Platycephalus laevigatus

Author

John Ford, Robert W. Day, Joshua S. Barrow, and John R. Morrongiello

Subjects
0106 biological sciences, 010504 meteorology & atmospheric sciences, Ecology, biology, 010604 marine biology & hydrobiology, Platycephalus laevigatus, Climate change, Aquatic Science, biology.organism_classification, 01 natural sciences, Oceanography, Seagrass, Productivity (ecology), Effects of global warming, Environmental science, Ecosystem, Fisheries management, Flathead, Ecology, Evolution, Behavior and Systematics, 0105 earth and related environmental sciences
Abstract

Human-driven climate change and habitat modification are negatively impacting coastal ecosystems and the species that reside within them. Uncovering how individuals of key species respond to environmental influences is crucial for effective and responsive coastal resource and fisheries management. Here, using an otolith based analysis, we recreated the growth history of rock flathead Platycephalus laevigatus from Corner Inlet, Victoria, Australia, over a 32 yr timeframe and related growth variation to changes in key environmental variables. Growth increased with higher temperatures during the fish growing season (December-May) and also increased with higher freshwater flow during the period important for seagrass growth (July- February). We hypothesise that fish are responding to enhanced productivity in the seagrass food web, driven by increased nutrient input from freshwater flows. Fish also appear to be responding to higher temperatures via a direct physiological pathway. We then predicted fish growth under 3 plausible climate change scenarios. Growth is predicted to increase across all our projections, because any predicted decrease in river flow will likely be offset by rapid predicted increases in temperature. Our results highlight the value of understanding the drivers of long-term growth variation in harvested fishes as this allows for the prediction of future productivity under a range of environmental and management scenarios.

Published
2018

43. Carbene Footprinting Reveals Binding Interfaces of a Multimeric Membrane-Spanning Protein

Author

Lucio Manzi, Andrew S. Barrow, Jonathan T. S. Hopper, Renata Kaminska, Colin Kleanthous, Carol V. Robinson, John E. Moses, and Neil J. Oldham

Subjects
0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, carbene footprinting, integral membrane proteins, protein structures, General Medicine, 010402 general chemistry, 01 natural sciences, protein labelling, mass spectrometry, 0104 chemical sciences
Abstract

© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Mapping the interaction sites between membrane-spanning proteins is a key challenge in structural biology. In this study a carbene-footprinting approach was developed and applied to identify the interfacial sites of a trimeric, integral membrane protein, OmpF, solubilised in micelles. The diazirine-based footprinting probe is effectively sequestered by, and incorporated into, the micelles, thus leading to efficient labelling of the membrane-spanning regions of the protein upon irradiation at 349 nm. Areas associated with protein–protein interactions between the trimer subunits remained unlabelled, thus revealing their location.

Published
2017

44. Induced metal-free star formation around a massive black hole seed

Author

Jarrett L. Johnson, Aycin Aykutalp, Kirk S. S. Barrow, and John H. Wise

Subjects
Physics, Supermassive black hole, H II region, 010308 nuclear & particles physics, Star formation, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Astrophysics - Astrophysics of Galaxies, Galaxy, Black hole, Supernova, Stars, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), 0103 physical sciences, Galaxy formation and evolution, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics
Abstract

The direct formation of a massive black hole is a potential seeding mechanism of the earliest observed supermassive black holes. We investigate how the existence of a massive black hole seed impacts the ionization and thermal state of its pre-galactic host halo and subsequent star formation. We show that its X-ray radiation ionizes and heats the medium, enhancing $\rm{H}_2$ formation in shielded regions, within the nuclear region in the span of a million years. The enhanced molecular cooling triggers the formation of a $\sim 10^4~{\rm M}_\odot$ metal-free stellar cluster at a star formation efficiency of $\sim 0.1\%$ in a single event. Star formation occurs near the edges of the H II region that is partially ionized by X-rays, thus the initial size depends on the black hole properties and surrounding environment. The simulated metal-free galaxy has an initial half-light radius of $\sim 10$ pc but expands to $\sim 50$ pc after 10 million years because of the outward velocities of their birth clouds. Supernova feedback then quenches any further star formation for tens of millions of years, allowing the massive black hole to dominate the spectrum once the massive metal-free stars die., Accepted for publication in ApJ Letters, 7 pages, 5 figures

Published
2019

46. G417(P) A feasibility study: what is the likely impact of introducing the royal college of radiologists’ standards (2017) for the investigation of suspected physical abuse?

Author

S Barrow and G Hann

Subjects
medicine.medical_specialty, Child protection, Referral, Current practice, business.industry, Radiological weapon, Radiation dose, medicine, Medical physics, Workload, Audit, business, Suspected physical abuse
Abstract

Background In 2017, the Royal College of Radiologists (RCR) published updated guidance on the radiological investigation of suspected physical abuse in children. New recommendations include CT head in all children under one year and that siblings or household contacts under two should also undergo radiological investigation. The latest guidance also recommends that all skeletal surveys are reported by two independent paediatric radiologists. Aims To audit current practice and assess the impact of introducing the RCR (2017) guidance in terms additional imaging needing to be performed. To assess the impact on workload of introducing double reporting for skeletal surveys. Methods Children under two who had suspected physical abuse were identified from the child protection team’s referral log. A retrospective analysis was performed of skeletal surveys from December 2014 to December 2016 using an audit proforma devised from the RCR guidelines (2017). IT systems were used to check for siblings aged ≤2 years. PACS was used to assess views obtained, time of final report and if surveys were double reported. Results 18 skeletal surveys were performed in the study period, all of which were deemed necessary. Results showed that compliance with the RCR guidance (2008) needed improvement: two skeletal surveys had missing views, only 20% of children who had an abnormal CT head had a follow-up MRI, 72% of skeletal surveys were reported within 72 hours and just 17% of children had follow-up imaging. If the RCR 2017 guidance were to be introduced, an additional three CT head scans would be required per year and two skeletal surveys would be required for siblings or household contacts. Double reporting would be required for 9 skeletal surveys per year. Conclusion New recommendations have implications for radiation dose but from the results, it would not increase the workload to an unmanageable degree. Based on results, we have chosen to introduce the latest RCR guidelines with the use of a proforma to improve compliance with standards.

Published
2019

47. Ion exchange and binding in selenium remediation materials using DNP-enhanced solid-state NMR spectroscopy

Author

Subhradip Paul, Jeremy J. Titman, Javier Torroba, Nathan S. Barrow, and Marco Mais

Subjects
Nuclear and High Energy Physics, Radiation, Ion exchange, 010405 organic chemistry, Inorganic chemistry, Groundwater remediation, chemistry.chemical_element, General Chemistry, 010402 general chemistry, 01 natural sciences, Selenate, 0104 chemical sciences, Ion, NMR spectra database, chemistry.chemical_compound, Solid-state nuclear magnetic resonance, Heteronuclear molecule, chemistry, Instrumentation, Selenium
Abstract

Selenate-loaded selenium water remediation materials based on polymer fibres have been investigated by dynamic nuclear polarization (DNP) enhanced solid-state NMR. For carbon-13 a significant reduction in experiment time is obtained with DNP even when compared with conventional carbon-13 NMR spectra recorded using larger samples. For the selenium remediation materials studied here this reduction allows efficient acquisition of {1H}-77Se heteronuclear correlation spectra which give information about the nature of the binding of the remediated selenate ions with the grafted side chains which provide the required ion exchange functionality.

Published
2019

48. Dynamics of Einstein–Aether scalar field cosmology

Author

Paliathanasis, A. Papagiannopoulos, G. Basilakos, S. Barrow, J.D.

Subjects
General Relativity and Quantum Cosmology
Abstract

We study the cosmological evolution of the field equations in the context of Einstein–Aether cosmology by including a scalar field in a spatially flat Friedmann–Lemaître–Robertson–Walker spacetime. Our analysis is separated into two separate where a pressureless fluid source is included or absent. In particular, we determine the critical points of the field equations and we study the stability of the specific solutions. The limit of general relativity is fully recovered, while the dynamical system admits de Sitter solutions which can describe the past inflationary era and the future late-time attractor. Results for generic scalar field potentials are presented while some numerical behaviours are given for specific potential forms. © 2019, The Author(s).

Published
2019

49. Increasing early life growth of hatchery-reared freshwater fish can improve stocking outcomes

Author

John D. Koehn, Jian D. L. Yen, John R. Morrongiello, and Joshua S. Barrow

Subjects
0106 biological sciences, Perch, Ecology, biology, Hatching, 010604 marine biology & hydrobiology, Aquatic Science, Oceanography, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Hatchery, medicine.anatomical_structure, Stocking, Animal science, Fish stocking, Freshwater fish, medicine, Macquaria ambigua, Ecology, Evolution, Behavior and Systematics, Otolith
Abstract

Stock enhancement is an important tool used to rebuild depleted fish populations or enhance recreational fishing. Hatchery-reared individuals can express trait differences, such as growth, which may affect later survival. However, there is little understanding of how early life growth variation affects stocking success. We examined early life growth of golden perch Macquaria ambigua and assessed how growth within hatcheries affects the survival of stocked fish. We measured daily otolith increment widths at 10, 20 and 30 days after hatching, but before stocking into lakes in south-eastern Australia. Mean growth decreased with age, but variation in growth increased. We then compared the early life growth of these individuals to those recaptured after 2 years at liberty (age-2+). Faster individual growth between 20 and 30 days was positively correlated with increased length at stocking. Mean growth between 20 and 30 days of age-2+ fish was higher than that of young-of-year fish, but among-individual variation in growth did not differ between the two groups. These results suggest that individuals with fast hatchery growth have increased survival to 2 years. We propose that enhancing growth within hatcheries may increase the survival of stocked fish, and thus the cost-effectiveness of fish stocking.

Published
2021

50. English Fusee Lever Pocket Watch : Its History, Development, Service and Repair

Author

Christopher S Barrow and Christopher S Barrow

Abstract

Following on from the success of his three previous books, The Pocket Watch, The Verge Pocket Watch and The American Pocket Watch, Chris Barrow has produced another clear and concise guide, aimed again at the enthusiastic amateur. This book concentrates on one particular type of watch, namely the English fusee lever. It combines a brief history of the development of the watch with a step-by-step manual covering the dismantling, cleaning, repair and reassembly of a variety of English fusee lever movements made during the nineteenth century. If you have acquired a pocket watch of this type, and would like to investigate its workings, perhaps with a view to getting it going again, then this book will help you step by step to reach that goal. It will also give you a better appreciation of the beauty of both the desing and technology of the English fusee lever pocket watch.

Published
2019

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