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Your search keyword '"Ruan, Wen-Juan"' showing total 35 results
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35 results on '"Ruan, Wen-Juan"'

21. A luminescent MOF as a fluorescent sensor for the sequential detection of Al3+ and phenylpyruvic acid.

Author

Wang, Qian, Du, Xiao-Meng, Zhao, Bo, Pang, Meili, Li, Yue, and Ruan, Wen-Juan

Subjects
HYDROXYL group, ACID analysis, AQUEOUS solutions, ION traps, METABOLIC disorders
Abstract

Aluminum is a widely distributed element with potential harm to human health, and the analysis of phenylpyruvic acid (PPA) is also routine in clinical uroscopy for metabolic disorders. In this work, we synthesized a UiO-66-backboned MOF, UiO-66-(OH)2, to construct an "off–on–off" platform for the sequential fluorescence detection of Al3+ and PPA. With incorporated hydroxyl groups, this MOF could capture Al3+ ions in aqueous solution and show enhanced fluorescence response through an excited-state intramolecular proton transfer mechanism. The binding affinity of PPA to Al3+ is stronger than that to the MOF; therefore, the further addition of this compound to UiO-66-(OH)2–Al3+ extracts the adsorbed Al3+ and restores the original weak emission of the MOF. UiO-66-(OH)2 exhibited good selectivity and sensitivity (DL = 47 nM for Al3+ and 100 nM for PPA) in both steps of detection and was successfully applied to the analysis of PPA in artificial urine. [ABSTRACT FROM AUTHOR]

Published
2020
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33. Two hexaazatriphenylene-pyrene based Hg2+ fluorescent chemosensors applicable for test paper detection.

Author

Li, Yue, Yang, Le-Le, Liu, Kun, Zhao, Fang-Yao, Liu, Huan, and Ruan, Wen-Juan

Subjects
CHEMORECEPTORS, PYRENE, BIOMAGNIFICATION, FLUORESCENCE yield, MOLECULAR orbitals
Abstract

Two chemosensors with large hexaazatriphenylene-pyrene chromophores were designed and synthesized. Both of them exhibit a selective fluorescence quenching response to Hg2+ in aqueous acetonitrile solution, and their detection limits are lower than the toxic level of Hg2+. Additionally, these compounds were successfully used for test paper detection. [ABSTRACT FROM AUTHOR]

Published
2015
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34. Enzyme-Assisted Metal-Organic Framework Sensing System for Diethylstilbestrol Detection.

Author

Li WJ, Chang L, Liu Q, Ning D, Yao XY, Li Y, and Ruan WJ

Abstract

As novel fluorescent-sensing materials, metal-organic frameworks (MOFs) have shown great potential in environmental monitoring. However, most of the researches are limited to traditional pollutants, whereas the application of MOFs to the detection of the pollutants with more complicated structures, such as endocrine disrupting chemicals (EDCs), has rarely been explored. The difficulties faced in the sensing of EDCs include their electronic stability and the structural similarity among homologues, which could be overcome by the incorporation of enzymatic reaction. In this work, the first example of enzyme-assisted MOF-fluorescent-sensing was developed for the analysis of diethylstilbestrol (DES, a synthetic estrogen). In this system, DES is first oxidized by HRP/H 2 O 2 quantitatively to its quinone form, and then the quinone product is selectively captured by a stilbene based luminescent MOF to induce fluorescence response. By the tandem sensitization and filtration of enzymatic reaction and MOF adsorption, this method shows high sensitivity (DL=89 nm) and can distinguish DES from other similar-structured EDCs., (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2017
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35. Luminescent Metal-Organic-Framework-Based Label-Free Assay of Polyphenol Oxidase with Fluorescent Scan.

Author

Li Y, Guo A, Chang L, Li WJ, and Ruan WJ

Subjects
Agaricales enzymology, Biocatalysis, Enzyme Assays, Ligands, Limit of Detection, Oxidation-Reduction, Quinones chemistry, Quinones metabolism, Solanum tuberosum enzymology, Spectrometry, Fluorescence, Substrate Specificity, Catechol Oxidase metabolism, Metal-Organic Frameworks chemistry
Abstract

Metal-organic frameworks (MOFs) are emerging in recent years as a kind of versatile fluorescent sensing materials, but their application to enzyme assays has rarely been studied. Here, the first example of a MOF-based label-free enzyme assay system is reported. A luminescent MOF was synthesized and applied to the activity analysis of polyphenol oxidase (PPO). With its distinct responses to the phenolic substrate and o-quinone product, this MOF could transduce the extent of PPO-catalyzed oxidation to fluorescence signal and enable the real-time monitoring of this reaction. Wide substrate adaptability and high sensitivity (detection limit=0.00012 U mL -1 ) were exhibited by this method, which meets the requirement of common bioanalysis. Interestingly, by the comparison with molecular capturing reagents, the heterogeneous nature of this MOF-based assay effectively preventing the interaction with the enzyme was proven, thus ensuring the authenticity of results., (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2017
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