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Crossmodal correspondences refer to when specific domains of features in different sensory modalities are mapped. We investigated how vowels and lexical tones drive sound–shape (rounded or angular) and sound–size (large or small) mappings among native Mandarin Chinese speakers. We used three vowels (/i/, /u/, and /a/), and each vowel was articulated in four lexical tones. In the sound–shape matching, the tendency to match the rounded shape was decreased in the following order: /u/, /i/, and /a/. Tone 2 was more likely to be matched to the rounded pattern, whereas Tone 4 was more likely to be matched to the angular pattern. In the sound–size matching, /a/ was matched to the larger object more than /u/ and /i/, and Tone 2 and Tone 4 correspond to the large–small contrast. The results demonstrated that both vowels and tones play prominent roles in crossmodal correspondences, and sound–shape and sound–size mappings are heterogeneous phenomena.

Current therapy does not provide significant benefits for patients with chronic stroke. Pre-clinical studies suggested that autologous adipose-derived stem cells have benefits for the treatment of chronic stroke. This Phase I open-label study was conducted to demonstrate the safety and efficacy of autologous adipose-derived stem cells (GXNPC1) in chronic stroke. Three patients with chronic stroke were treated with stereotactic implantation of autologous adipose-derived stem cells (1 × 108 cells). The primary endpoints of safety evaluation included adverse events, over a 6 months post-implantation period. The secondary endpoints included improvements in neurological functions. Evolutional change of brain parenchyma was also followed with magnetic resonance imaging (MRI). All three participants improved significantly at 6 months follow-up. The extent of improvement from pre-treatment was: National Institutes of Health Stroke Scale improved 5-15 points, Barthel Index: 25-50 points, Berg balance scale 0-21 points and Fugl-Meyer modified sensation 3-28 points. All three patients had signal change along the implantation tract on MRI one month after surgery. There is no related safety issue through 6 months observation. Clinical measures of neurological symptoms of these patients with chronic stroke improved at 6 months without adverse effects after implantation of autologous adipose-derived stem cells (GXNPC1), which might be correlated with post-implantation changes on brain MRI. Clinical Trial Registration-URL: https://clinicaltrials.gov/ct2/show/NCT02813512?term=ADSC&cond=Stroke&cntry=TW&draw=2&rank=1 Unique identifier: NCT02813512.

Vision is typically dominant over audition or touch in human adults. One classic example is the Colavita visual dominance effect: The presentation of a tone sometimes goes undetected when it is paired with a flash even though it is well detected when presented alone. We investigated whether the Colavita visual dominance effect is modulated by stimulus uncertainty in the temporal and spatial domains. In a simple discrimination task, participants were asked to press a predesignated key when detecting a flash, another key when detecting a tone, and both keys when detecting both a flash and a tone. Temporal uncertainty was increased by introducing temporal jitter between trials (Experiment 1), and spatial uncertainty was increased by shifting the flash to different locations (Experiment 2). The Colavita visual dominance effect was reduced when temporal uncertainty was increased, while it remained similar when spatial uncertainty was increased. We therefore demonstrate a novel consideration, where increasing temporal uncertainty balances the competition between vision and audition, suggesting that people's degree of sensory dominance is malleable. Our result therefore highlights the concept that intersensory competition is susceptible to the temporal predictability of the stimulus, which provides critical insights into the design of effective warning systems in the field of ergonomics.

Purpose We developed a stereo task that is based on a motion direction discrimination to examine the role that depth can play in disambiguating motion direction. Methods In this study, we quantified normal adults’ static and dynamic (i.e., laterally moving) stereoscopic performance using a psychophysical task, where we dichoptically presented randomly arranged, limited lifetime Gabor elements at two depth planes (one plane was at the fixation plane and the other at an uncrossed disparity relative to the fixation plane). Each plane contained half of the elements. For the dynamic condition, all elements were vertically oriented and moved to the left in one plane and to the right in another plane; for the static condition, the elements were horizontally oriented in one plane and vertically oriented in another plane. Results For the range of motion speed that we measured (from 0.17°/s to 5.33°/s), we observed clear speed tuning of the stereo sensitivity (P = 3.0 × 10−5). The shape of this tuning did not significantly change with different spatial frequencies. We also found a significant difference in stereo sensitivity between stereopsis with static and laterally moving stimuli (speed = 0.67°/s; P = 0.004). Such difference was not evident when we matched the task between the static and moving stimuli. Conclusions We report that lateral motion modulates human global depth perception. This motion/stereo constraint is related to motion velocity not stimulus temporal frequency. We speculate that the processing of motion-based stereopsis of the kind reported here occurs in dorsal extrastriate cortex.

Crossmodal correspondences refer to the fact that certain domains of features in different sensory modalities are associated with each other. Here, we investigated the crossmodal correspondences between speech sounds and visual shapes. Specifically, we tested whether the classification dimensions of English vowels (front–central–back) and consonants (voiced–voiceless, sonorant–obstruent, and stop–continuant) correspond to visual shapes along a bipolar rounded–angular dimension. We adapted eighteen meaningless pseudowords from a previous study that corresponded to either the round or the sharp concept. On each trial, the participants heard one of the pseudowords and saw a rounded shape and an angular shape presented side-by-side on the monitor. Participants judged which shape provided a better match to the spoken pseudoword. A logistic regression was conducted in order to elucidate the effectiveness of classification dimensions of phonemes when predicting variations in the sound–shape matchings. The results demonstrated that the sound–shape matchings were predictable using front–central–back dimensions of vowels, and voiced–voiceless and stop–continuant dimensions of consonants. Hence, we verified that sound–shape matching is underpinned by contrasting dimensions in both vowels and consonants, therefore demonstrating crossmodal correspondences at the phonetic level.

The Bouba/Kiki effect constitutes a classic sound-shape correspondence, with the meaningless sounds "Bouba" and "Kiki" being mapped onto smooth and spiky patterns, respectively. While it is commonly believed that the Bouba/Kiki effect is driven by the local rounded and angular features of a pattern, here we investigated the importance of an alternative level of visual processing-namely the global contours. We adopted compound radial frequency (RF) patterns and segmented them into convexities (outward curves) or concavities (inward curves). Note that convexities are more informative in terms of inferring the global contour than concavities. When the perceptual grouping of segments was facilitated by increasing their length, the grouping of convexities was more efficient than that of concavities as manifested by the closer matching judgments to the compound RF patterns. When we interfered with the perceptual grouping of segments by rotating each segment by 180°, the matching consensus of convexities was higher when they were presented in the original than in the reversed orientation. Hence, the Bouba/Kiki effect was susceptible to the factors modulating the perceptual grouping process going from segments to the global contour, suggesting that the Bouba/Kiki effect may occur at the global level of shape perception. Sound-shape correspondences would therefore seem to be expressed at multiple levels of information processing, furthering our understanding of the development, underpinning neural mechanisms, and applications of crossmodal correspondences. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

The Turtle Island (Kueishantao) is situated in the southernmost Okinawa Trough, a back-arc basin to the north of the Ryukyu Arc. Based on bathymetry around the Turtle Island, obviously hummocky seafloor indicating slope failures have occurred. The Turtle Island could have erupted four times in the last 7000 years. Previous studies have pointed out that volcanic eruptions may be related to island flank collapses. The bathymetric hummocky feature reveals submarine debris avalanches in the north, south and east side. In order to understand the landslide mechanism, we have conducted detailed marine geophysical surveys in the north part of the debris avalanches. The multi-beam bathymetric data, sub-bottom profiler, sidescan sonar, sparker seismic reflection data and remotely operated vehicle (ROV) dives data are used to identify the landslide features, including the depositional and erosional characters. Our results show that the debris avalanche is probably related to the horseshoe scar of the subaerial flank collapsed event. The debris avalanches display a runout distance of up to 4 km northeastward and form a ~4 km2 hummocky terrain with displaced blocks. The biggest block could be ~50 m high and 50 m in diameter. Identified by the sparker seismic data, the chaotic facies of the landslide deposits can be divided into three MTD (Mass Transport Deposit) units (MTD1, MTD2 and MTD3). The main volcanic debris avalanche deposits are identified as MTD3 with a characteristic of broken and discontinuous lateral reflections. Correlated with seismic data and sub-bottom profiles, multiple landslide events are recognized on the basis of different MTD units. The last landslide event is probably related to a faulting and a slope failure of the island and could be highly associated with a climatic event.

Studies on binocular combination and rivalry show that short-term deprivation strengthens the contribution of the deprived eye in binocular vision. However, whether short-term monocular deprivation affects temporal processing per se is not clear. To address this issue, we conducted a study to investigate the effect of monocular deprivation on dichoptic temporal synchrony. We tested ten adults with normal vision and patched their dominant eye with an opaque patch for 2.5 h. A temporal synchrony paradigm was used to measure if temporal synchrony thresholds change as a result of monocular pattern deprivation. In this paradigm, we displayed two pairs of Gaussian blobs flickering at 1 Hz with either the same or different phased- temporal modulation. In Experiment 1, we obtained the thresholds for detecting temporal asynchrony under dichoptic viewing configurations. We compared the thresholds for temporal synchrony between before and after monocular deprivation and found no significant changes of the interocular synchrony. In Experiment 2, we measured the monocular thresholds for detecting temporal asynchrony. We also found no significant changes of the monocular synchrony of either the patched eye or the unpatched eye. Our findings suggest that short-term monocular deprivation induced-plasticity does not influence monocular or dichoptic temporal synchrony at low temporal frequency.

The southernmost Okinawa Trough back-arc basin is an active and young basin formed just after the collision of the Philippine Sea Plate against the Eurasian continental margin. The back-arc extension occurs intensively because of the southward or southeastward migration of the southernmost Ryukyu Arc, or the roll-back of the Philippine Sea Plate. To better understand the active tectonics and volcanism of the southernmost Okinawa Trough, we have conducted deep-tow sub-bottom profiler and side-scan sonar surveys across the back-arc basin. Our results show that the volcanism of the southernmost Okinawa Trough is distributed in the southern half of the back-arc basin and occurs along some linear or branched zones roughly parallel to the trough axis. Volcanic seamounts are obviously located along the central depression of the basin and their sizes show lateral variation. On the other hand, the northern half of the southernmost Okinawa Trough back-arc basin has almost no volcanic activity, but contains more brittle normal faults. It is noted that gas plumes out of seafloor are generally associated with hydrothermal mounds or activities, instead of volcanic seamounts. We suggest that the more complete rifting of the southernmost Okinawa Trough back-arc is limited to the east of ~122o30′E. To the west of ~122o30’E, the back-arc extension could be still influenced by the inherited NE-SW trending structures of the continental crust created during the former Taiwan orogeny in this area.

Currently, the only effective therapy for cirrhosis of the liver is liver transplantation. However, finding a compatible liver is difficult due to the low supply of healthy livers and the ever-increasing demand. However, stem-cell therapy may offer a solution for liver cirrhosis; for example, GXHPC1 therapy preparation contains adipose-derived mesenchymal stem cells (AD-MSCs) and was developed for the treatment of liver cirrhosis. In our previous report, animal studies suggested that treatment of a diseased liver via GXHPC1 transplantation can abrogate liver fibrosis and facilitate recovery of liver function. In our current human trial, patients with liver cirrhosis were included. Their adipose tissue was harvested from the subcutaneous fat of the abdominal wall during surgery. AD-MSCs were cultured and suspended at a concentration of 100 million cells in 1 ml of physiological saline (i.e., GXHPC1). This human study passed the Taiwan Food and Drug Administration IND inspection and received Phase I clinical trial permission. The trial was conducted with six patients with liver cirrhosis to demonstrate the safety and efficacy of administering GXHPC1. Intrahepatic injection of GXHPC1 did not cause any safety issues in the analysis of adverse drug reactions and suspected unexpected serious adverse reactions, and showed a tendency for improvement of liver function, METAVIR score, Child–Pugh score, MELD score, and quality of life for patients with liver cirrhosis.

Stroke is a result of cerebral ischemia that triggers a cascade of both physiological and biochemical events. No effective treatment is available for stroke; however, stem cells have the potential to rescue tissue from the effects of stroke. Adipose-derived stem cells (ADSCs) are an abundant source of adult stem cells; therefore, ADSC therapy can be considered as a future strategy for regenerative medicine. However, more research is required to improve the effectiveness of transplanted ADSCs as a treatment for stroke in the mouse stroke model. Ligustilide, isolated from the herb Angelica sinensis, exhibits a protective effect on neurons and inhibits inflammation. We also demonstrated that ligustilide treatment increases the expression levels of homing factors such as SDF-1 and CXCR4. In the present study, we evaluated the therapeutic effects of ADSC transplantation and ligustilide treatment in a mouse thromboembolic stroke model by behavioral tests, including beam walking, locomotor activity, and rotarod analysis. ADSCs pretreated with ligustilide were transplanted into the brains of stroke mice. The results showed that the therapeutic effect of ADSCs pretreated with ligustilide was better than that of ADSCs without ligustilide pretreatment. There was no difference between the recovery of mice treated by ADSC transplantation combined with subcutaneous ligustilide injection and that of mice treated only with ADSCs. The TUNEL assay showed fewer apoptotic cells in the brains of mice transplanted with ADSCs pretreated with ligustilide as well as in those without pretreatment. In summary, pretreatment of ADSCs with ligustilide improves the therapeutic efficacy of ADSC transplantation. The results of this study will help improve stem cell therapies being developed for future clinical applications.

We examined the ability of people to evaluate their confidence when making perceptual judgments concerning a classic crossmodal correspondence, the Bouba/Kiki effect: People typically match the "Bouba" sound to more rounded patterns and match the "Kiki" sound to more angular patterns instead. For each visual pattern, individual participants were more confident about their own matching judgments when they happened to fall in line with the consensual response regarding whether the pattern was rated as "Bouba" or "Kiki". Logit regression analyses demonstrated that participants' confidence ratings and matching judgments were predictable by similar regression functions. This implies that the consensus and confidence underlying the Bouba/Kiki effect are underpinned by a common process, whereby perceptual features in the patterns are extracted and then used to match the sound according to rules of crossmodal correspondences. Combining both matching and confidence measures potentially allows one to explore and quantify the strength of associations in human knowledge.

The accepted and peer reviewed manuscript to the article Despite the rapid growth of research on the crossmodal correspondence between visually presented shapes and basic tastes (e.g., sweet, sour, bitter, and salty), most studies that have been published to date have focused on shape contour (roundness/angularity). Meanwhile, other important features, such as symmetry, as well as the underlying mechanisms of the shape–taste correspondence, have rarely been studied. Over two experiments, we systematically manipulated the symmetry and contours of shapes and measured the influences of these variables on shape–taste correspondences. Furthermore, we investigated a potential underlying mechanism, based on the common affective appraisal of stimuli in different sensory modalities. We replicated the results of previous studies showing that round shapes are associated with sweet taste, whereas angular shapes are associated with sour and bitter tastes. In addition, we demonstrated a novel effect that the symmetry group of a shape influences how it is associated with taste. A significant relationship was observed between the taste and appraisal scores of the shapes, suggesting that the affective factors of pleasantness and threat underlie the shape–taste correspondence. These results were consistent across cultures, when we compared participants from Taiwanese and Western (UK, US, Canada) cultures. Our findings highlight that perceived pleasantness and threat are culturally common factors involved in at least some crossmodal correspondences. 1, Forfatterversjon

In the context of natural scenes, we applied the pattern-masking paradigm to investigate how image structure and phase alignment affect contrast-gain control in binocular vision. We measured the discrimination thresholds of bandpass-filtered natural-scene images (targets) under various types of pedestals. Our first experiment had four pedestal types: bandpass-filtered pedestals, unfiltered pedestals, notch-filtered pedestals (which enabled removal of the spatial frequency), and misaligned pedestals (which involved rotation of unfiltered pedestals). Our second experiment featured six types of pedestals: bandpass-filtered, unfiltered, and notch-filtered pedestals, and the corresponding phase-scrambled pedestals. The thresholds were compared for monocular, binocular, and dichoptic viewing configurations. The bandpass-filtered pedestal and unfiltered pedestals showed classic dipper shapes; the dipper shapes of the notch-filtered, misaligned, and phase-scrambled pedestals were weak. We adopted a two-stage binocular contrast-gain control model to describe our results. We deduced that the phase-alignment information influenced the contrast-gain control mechanism before the binocular summation stage and that the phase-alignment information and structural misalignment information caused relatively strong divisive inhibition in the monocular and interocular suppression stages. When the pedestals were phase-scrambled, the elimination of the interocular suppression processing was the most convincing explanation of the results. Thus, our results indicated that both phase-alignment information and similar image structures cause strong interocular suppression.

Objective Both genetic and environmental factors are thought to play a role in the pathogenesis of strabismus and subsequent ocular dominance and amblyopia. Our purpose was to compare the characteristics of sensory visual function in 2 adult monozygotic (genetically identical) twins who presented with esotropia at different ages. Methods Monocular and binocular visual function was measured in the twins. Contrast sensitivity was used to assess monocular function. Suppressive and stereoscopic measurements were undertaken to assess binocular function. All tests were run using a 2-alternative forced choice psychophysical procedure. Eighteen short tandem repeats (STR) were genotyped across the genome in both twins to determine their exact relationship. Results Twin 1 (nondominant eye OD) was diagnosed with esotropia at 6 months of age, whereas twin 2 (nondominant eye OS) was diagnosed with esotropia at 5 years of age. They underwent a similar corrective surgical intervention soon after diagnosis to correct their esodeviations. Monocular contrast sensitivity was poorer for twin 1, particularly at intermediate spatial frequencies. In addition, twin 1 demonstrated complete suppression and unmeasurable stereoscopic function (>300 seconds). On the other hand, twin 2 demonstrated fusion, exhibited only mild suppression, and had near-normal (28 seconds) stereoscopic function. All STR alleles were identical in the twins, proving monozygosity. Conclusions Sensory measurements of monocular and binocular visual function in these genetically proven monozygotic twins were significantly different, with the earlier onset of esotropia associated with reduced visual function. Twin 2, whose esotropia was diagnosed at the age of 5 years, had near-normal visual function, both monocularly and binocularly. To the best of our knowledge, this represents the first study of a genetically identical sibling pair with strabismus. By eliminating the genetic differences between these patients, we are able to make powerful observations about the effect of environment on visual function in strabismus.

A plaid is a combination of two gratings whose orientations are orthogonal to each other with the same or similar contrasts. We used plaid patterns as stimuli to investigate the mechanisms underlying the detection of a plaid to understand how the visual system combines information from orientation-selective channels. We used a masking paradigm in which an observer was required to detect a target (either a spiral or a plaid) superimposed on a pedestal. We measured the target threshold versus pedestal contrast (TvC) functions at 7 pedestal contrasts for various target-pedestal combinations with a temporal 2AFC paradigm and a staircase procedure. All TvC functions, except the one with an orthogonal spiral pedestal, showed a dipper shape, although the position of the dip and the slope varied across conditions. The result can be explained by a multiple-mechanism divisive inhibition model, which contains several orientation-selective mechanisms. The response of each mechanism is the excitation of a linear filter divided by a broadband inhibitory input. The threshold is determined by a nonlinear combination of the responses of those mechanisms. Alternative models with mechanism(s) specific for plaid did not provide a better description of the data. Thus, a plaid pattern is mediated by a combination of orientation-selective mechanisms. An early plaid-specific mechanism is not necessary for plaid detection.

Currently, there is not an effective therapy for cirrhosis of the liver except for liver transplant. However, finding a compatible liver is difficult due to the low supply and increased demand for healthy livers. Stem cell therapy may be a solution for liver cirrhosis. In our previous report, stem cells from Wharton's jelly and bone marrow were shown to improve liver function in a chemically induced liver fibrosis animal model. However, the immunological rejection of an allograft is always a risk for clinical application. In this study proposal, we suggest using human adipose-derived stem cells (ADSCs) because they are an immune-privileged cell type; they lack human leukocyte antigen-DR expression, and they also suppress the proliferation of activated allogenic lymphocytes and inhibit the production of inflammatory cytokines. In addition, ADSCs contain a sufficient amount of adult stem cells for autologous transplantation. Based on these benefits, ADSCs are promising candidates for clinical application when compared to other stem cell types. The aim of our study will be to investigate the safety and efficacy of autologous ADSCs for the clinical treatment of liver cirrhosis.