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Aroyl hydrazones have been intensively investigated over the last decades due to their various biological properties such as anticancer, antibacterial and antimicrobial effects. Herein, we examine the anti- proliferative effect of two new aroyl hydrazones used in a combination with AVPI- and RGD – peptides. The anti-proliferative activity is checked by MTT assay after 72h of treatment on MDA-MB-231 breast cancer cells. Though the aroyl hydrazone derivatives used as single agents shows a high activity, the combination is found not beneficial.

Resveratrol is a stilbene-type bioactive molecule with a broad spectrum of reported biological effects. In this sense, the current work provides a comprehensive literature analysis on resveratrol, representing a highly-researched commercially available dietary ingredient. Bibliometric data were identified by means of the search string TOPIC=("resveratrol*") and analyzed with the VOSviewer software, which yielded 17,561 publications extracted from the Web of Science Core Collection electronic database. 'I'he ratio of original articles to reviews was 9.5:1. More than half of the overall manuscripts have been published since 2013. Major contributing countries were USA, China, Italy, South Korea, and Spain. Most of the publications appeared in journals specialized in biochemistry and molecular biology, pharmacology and pharmacy, food science technology, cell biology, or oncology. The phytochemicals or phytochemical classes that were frequently mentioned in the keywords of analyzed publications included, in descending order: resveratrol, trans-resveratrol, polyphenols, flavonoids, quercetin, stilbenes, curcumin, piceatannol, cis-resveratrol, and anthocyanins.

Aroylhydrazones have been intensively investigated in recent years due to their versatile properties and applications. Many compounds of this type are biologically active as anticancer, antibacterial and antimicrobial agents. In addition, hydrazones as chelating agents were investigated as potential drugs for treatment of iron-overload associated diseases. In the present work, a group of 17 derivatives was studied for cytotoxic activity, as a part of our investigations on aroylhydrazones. The cytotoxic effect of the compounds was tested on non-tumor cells 3T3 and MCF10 and tumor cell lines HepG2, MCF7 and MDA-MB-231. Compound 11 exhibited the highest growth inhibitory effects on cell lines and significantly higher in tumor cell lines than in non-tumor cell lines. Compounds 5, C and E also show significantly higher cytotoxic activity in tumor cell lines than non-tumor cell lines in the experiment. The study makes it possible to assess the interaction between the structure and activity of the compounds and to understand the further development of hydrazones as more potent and selective antineoplastic agents.

The natural tridecapeptide neurotensin has been emerged as a promising therapeutic scaffold for the treatment of neurological diseases and cancer. In this work, we aimed to identify the top 100 most cited original research papers as well as recent key studies related to neurotensins. The Web of Science Core Collection database was searched and the retrieved research articles were analyzed by using the VOSviewer software. The most cited original articles were published between 1973 and 2013. The top-cited article was by Carraway and Leeman reporting the discovery of neurotensin in 1973. The highly cited terms were associated with hypotension and angiotensin-converting-enzyme. The conducted analysis reveals the therapeutic potentials of neurotensin, and further impactful research toward its clinical development is warrantied., MG Georgieva, AA Balacheva, TI Pajpanova, L Milella, AG Atanasov and NT Tzvetkov acknowledge the support by the Bulgarian National Science Found (BNSF) under grant number KP-06-OPR 03/8., info:eu-repo/semantics/publishedVersion