New aroyl hydrazones combined with specific peptide analogues: looking for possible enhanced cytotoxic effects

Aroyl hydrazones have been intensively investigated over the last decades due to their various biological properties such as anticancer, antibacterial and antimicrobial effects. Herein, we examine the anti- proliferative effect of two new aroyl hydrazones used in a combination with AVPI- and RGD – peptides. The anti-proliferative activity is checked by MTT assay after 72h of treatment on MDA-MB-231 breast cancer cells. Though the aroyl hydrazone derivatives used as single agents shows a high activity, the combination is found not beneficial.