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BackgroundThe closure of a patent foramen ovale (PFO) using transseptal puncture has particular advantages and disadvantages. Thus, transseptal puncture should be re-evaluated in detail.AimsWe aimed to assess the effectiveness of the detailed transseptal puncture technique in patients who underwent PFO closure due to cryptogenic stroke or transient ischemic attack in terms of residual shunts and atrial fibrillation.MethodsWe prospectively analyzed 144 consecutive patients who underwent PFO closure by the detailed transseptal puncture technique between February 2013 and April 2023 in two centers. All of the patients had a >10 mm long-tunnel PFO.ResultsThe procedural success rate was 100%. However, after the procedure, moderate pericardial effusion developed in one patient (0.7%) and an acute pulmonary embolism related to femoral vein thrombosis was observed in one patient (0.7%) during the first month. Complications related to the procedure were noted in two patients (1.4%) during the first month of follow-up. Residual shunts were observed in 1.4% of cases after PFO closure.ConclusionWe demonstrated that the detailed transseptal technique is safe and effective for PFO closure. The detailed transseptal PFO closure technique significantly reduced the risk of atrial fibrillation, and the occurrence of residual shunts was significantly low following the closure.

Abstract Amorphous photonic structures are mesoscopic optical structures described by electrical permittivity distributions with underlying spatial randomness. They offer a unique platform for studying a broad set of electromagnetic phenomena, including transverse Anderson localization, enhanced wave transport, and suppressed diffusion in random media. Despite this, at a more practical level, there is insufficient work on both understanding the nature of optical transport and the conditions conducive to vector-wave localization in these planar structures, as well as their potential applications to photonic nanodevices. In this study, we fill this gap by investigating experimentally and theoretically the characteristics of optical transport in a class of amorphous photonic structures and by demonstrating their use to some basic waveguiding nanostructures. We demonstrate that these 2-D structures have unique isotropic and asymmetric band gaps for in-plane propagation, controlled from first principles by varying the scattering strength and whose properties are elucidated by establishing an analogy between photon and carrier transport in amorphous semiconductors. We further observe Urbach band tails in these random structures and uncover their relation to frequency- and disorder-dependent Anderson-like localized modes through the modified Ioffe-Regel criterion and their mean free path - localization length character. Finally, we illustrate that our amorphous structures can serve as a versatile platform in which photonic devices such as disorder-localized waveguides can be readily implemented.

Abstract Adolescence is a timed process with an onset, tempo, and duration. Nevertheless, the temporal dimension, especially the pace of maturation, remains an insufficiently studied aspect of developmental progression. The primary objective is to estimate the precise influence of pubertal maturational tempo on the configuration of associative brain regions. To this end, the connection between maturational stages and the level of hierarchical organization of large‐scale brain networks in 12‐13‐year‐old females is analyzed. Skeletal maturity is used as a proxy for pubertal progress. The degree of maturity is defined by the difference between bone age and chronological age. To assess the level of hierarchical organization in the brain, the temporal dynamic of closed eye resting state high‐density electroencephalography (EEG) in the alpha frequency range is analyzed. Different levels of hierarchical order are captured by the measured asymmetry in the directionality of information flow between different regions. The calculated EEG‐based entropy production of participant groups is then compared with accelerated, average, and decelerated maturity. Results indicate that an average maturational trajectory optimally aligns with cerebral hierarchical order, and both accelerated and decelerated timelines result in diminished cortical organization. This suggests that a “Goldilocks rule” of brain development is favoring a particular maturational tempo.

The visualization of the cervix and subsequent manipulations during transcervical applications in sheep might require a degree of straining reflexes while using the Collin Speculum. Therefore, this study aimed to develop and to evaluate the feasibility of a new alternative speculum design for non-surgical assisted reproductive procedures in small ruminants. Collin speculum (CS) and the new "Onder speculum" (OS) were used to assess cervical entrance in 30 ewes. The OS efficiency for a successful cervical retraction was also evaluated. Data showed that the cervical entrance was visible in 8 out of the 30 females with CS, while it was observed in all the animals when using OS (P

Sosyal politikanın önemli araçlarından biri olan sosyal harcamaların gelir dağılımı üzerindeki olumlu etkisi çok fazla tartışma konusu olmazken, bu harcamaların ekonomik büyüme üzerindeki etkisi literatürde geniş bir tartışma alanı oluşturmaktadır. Bu çalışmanın amacı; Türkiye’deki sosyal harcamalar ile gelir dağılımı ve ekonomik büyüme arasındaki ilişkiyi ortaya koymaktır. Sosyal harcamaların ekonomik büyüme ve gelir dağılımı üzerindeki etkisi sırasıyla 1980-2019 ve 1987-2019 dönemleri için Fourier ADL eşbütünleşme testi ile belirlenmiştir. Fourier ADL eşbütünleşme testi sonuçları eşbütünleşme ilişkisini ortaya koymuştur. FMOLS tahminleri, sosyal harcamaların ekonomik büyüme ve gelir dağılımı üzerindeki etkilerinin olumlu olduğunu göstermiştir. Sonuç olarak, çalışma Türkiye’de kamu politika yapıcılarına sosyal harcamaları artırmayı önermektedir.

Abstract Background Northwest Syria (NWS) is a conflict area with challenging political, economic, demographic and social dynamics. The region has a high number of internally displaced persons with increasingly disrupted delivery of basic services, including healthcare. Mental health needs have been increasing in the region while the infrastructure and capacity of the health sector has been negatively affected by the conflict. This study aimed to explore the provision of mental health and psychosocial support (MHPSS) services to communities in NWS (including healthcare workers) and to assess the experiences of beneficiaries with MHPSS services. Methods The study followed a mixed-methods research design that included qualitative and participatory methods (44 semi-structured interviews and a group model building workshop with 15 participants) as well as a survey with 462 beneficiaries. Results Findings suggested an improvement of MHPSS services in the region over the last few years due to the creation of a specific Technical Working Group for MHPSS that contributed to assessment of community needs and support of the MHPSS response. The key elements of this response were: (1) training non-specialized health workers to address the shortage in specialized providers; (2) securing funding and coordination of services between different organizations; and (3) addressing gaps in the availability and geographical distribution of other needed resources, such as medicines. While those elements contributed to improving access to services and the quality of services—especially among health workers seeking MHPSS services—findings suggested gaps in the sustainability of services and a need to scale up those interventions in an integrated approach. Conclusion The study findings add to the evidence base on the challenges in scaling up MHPSS interventions and their long-term sustainability concerns. Priority actions should address the intermittent funding of the MHPSS response, incorporate MHPSS outputs and outcomes in the reimbursement of routine services, improve coordination between health partners and non-health actors in order to expand the scope of MHPSS response, and address the inequitable availability of resources in the region.

Abstract High-dimensional quantum entanglement is a cornerstone for advanced technology enabling large-scale noise-tolerant quantum systems, fault-tolerant quantum computing, and distributed quantum networks. The recently developed biphoton frequency comb (BFC) provides a powerful platform for high-dimensional quantum information processing in its spectral and temporal quantum modes. Here we propose and generate a singly-filtered high-dimensional BFC via spontaneous parametric down-conversion by spectrally shaping only the signal photons with a Fabry-Pérot cavity. High-dimensional energy-time entanglement is verified through Franson-interference recurrences and temporal correlation with low-jitter detectors. Frequency- and temporal- entanglement of our singly-filtered BFC is then quantified by Schmidt mode decomposition. Subsequently, we distribute the high-dimensional singly-filtered BFC state over a 10 km fiber link with a post-distribution time-bin dimension lower bounded to be at least 168. Our demonstrations of high-dimensional entanglement and entanglement distribution show the singly-filtered quantum frequency comb’s capability for high-efficiency quantum information processing and high-capacity quantum networks.

The aim of the present study was to evaluate the effects of insulin supplemented extender on bull semen at a post-thaw stage. Semen samples were collected four times from a Zavot bull which is endangered species in Türkiye. Semen samples were diluted with Tris based extender supplemented with 10 IU or 15 IU of insulin and control. Motility and plasma membrane integrity were evaluated by a phase-contrast microscope. Acrosome integrity (Fitc-Peanut Agglutinin), mitochondrial membrane potential (Rhodamine 123), nitric oxide level (4,5-Diaminofluorescein-2/diacetate) were evaluated with dual staining propidium iodide using flow cytometry. Motility and plasma membrane functional integrity were better preserved compared to control group (P0.05), but increased insulin negatively affected acrosome integrity (p0.05). There were not any significant differences among groups in terms of nitric oxide level (P>0.05). In conclusion, it was thought that insulin involved in energy metabolism and improved preservation of bull semen.

Time-reversibility, which is inherent in many physical systems, is crucial in tailoring temporal waveforms for optimum light–matter interactions. Among the time-reversible atomic systems, narrowband biphoton sources are essential for efficient quantum storage. In this work, we demonstrate time-reversed and fully time-resolved ultra-narrowband single-sided biphoton frequency combs with an average free-spectral range (FSR) of 42.66 MHz and an average linewidth of 4.60 MHz in the telecommunication band. We experimentally observe the fully time-resolved and reversible temporal oscillations by second-order cross correlation and joint temporal intensity measurements. The potential benefits of the time-reversed and fully time-resolved temporal oscillations from our source include enhancing the efficiency of quantum storage in atomic memories and maximizing the utilization of temporal information in multimode biphoton frequency combs. We further verify the heralded single-photon state generation from the multimode biphoton frequency combs by using Hanbury Brown and Twiss interference measurements. To the best of our knowledge, this 42.66 MHz FSR of our photon-pair source represents the narrowest among all of the different configurated biphoton sources reported to date. This ultra-narrow FSR and its 4.60 MHz linewidth provide the highest frequency mode number of 5786 and the longest coherence time among all the singly configurated biphoton sources so far. Our time-reversed and fully time-resolved massive-mode biphoton source could be useful for high-dimensional quantum information processing and efficient time–frequency multiplexed quantum storage toward long-distance and large-scale quantum networks.

Osmanlı Devleti’nde Batı müziği ile ilk temasın Kanuni Sultan Süleyman Dönemi’nde gerçekleştiği düşünülse de devletler arası herhangi bir yazışmanın günümüzde bulunmaması bu bilgiyi dayanaksız bırakmaktadır. Resmî belgeler ancak III. Selim Dönemi’yle günümüze ulaşmıştır. Bu sebeple III. Selim’in oluşturduğu düzenli ordu olan Nizâm-ı Cedîd bünyesinde bulunan boru takımı Osmanlı’nın ilk Batı müziği bandosunu temsil etmektedir. Osmanlı’nın geneline yayılmayan bu oluşumun başlattığı Batı’ya dönüş, Sultan II. Mahmud Dönemi’yle hız kazanmıştır. Sultan Mahmud’un güçlü iradesiyle dağılan Yeniçeri Ocağı, beraberinde Mehterhâne-i Hümâyun’u da olumsuz anlamda etkilemiştir. Mehterhâne-i Hümâyun teşkilâtı, Yeniçeri Ocağı’nı hatırlattığı düşüncesiyle görev kapsamı daraltılarak Batılı anlamda eğitim veren Mûzikâ-yı Hümâyun’un gölgesinde kalmıştır. Mûzikâ-yı Hümâyun ile Batı müziği resmen Osmanlı sarayına girmiş ve bu bağlamda Osmanlı’da Batı müziği formlarında besteler ortaya çıkmaya başlamıştır. Çalışmamızın ana konusunu ihtiva eden Bülbül Opereti ise, Mûzikâ-yı Hümâyun’da yetişen ünlü bestekâr Muallim İsmail Hakkı Bey tarafından Türk mûsikîsi makamlarıyla 3 perde olarak bestelenmiştir. Hicrî 1337 yılında Cemal Sahir Bey, Bülbül Operetini konu edindiği Temsil-i Mûsikî Rehberi adlı matbu bir eser kaleme almıştır. Bu çalışma ile amaçlanan Temsil-i Mûsikî Rehberi adlı matbu eserin transkripsiyonu yapılarak Bülbül Opereti’nin incelenmesidir.

Abstract The aim of this study is to investigate the acute effects of hip mobility exercises applied before anaerobic activities on vertical jump, 1 repetition maximum (1TM) and isometric strength performances. For this purpose, 12 male athletes with a high level of training (age = 21 ± 1.2 years; height = 180 ± 0.05 m; body weight = 88.08 ± 9.17 kg) voluntarily participated in the study. Before starting the study, an approval report was obtained from the Sakarya University of Applied Sciences Ethics Committee and all athletes signed a voluntary consent form before the study. All participants were asked to perform a standard 15-minute dynamic warm-up procedure (dynamic stretching exercises related to cycling and tests) on the first measurement day, and then, in order to avoid fatigue in the athletes, 1 TM ( 1 Repetition Maximum) strength tests were applied. On the second measurement day, the subjects performed 8 different hip mobility exercises (2 sets x 20 seconds for each exercise) with the same 15-minute dynamic warm-up protocol and re-applied the tests applied on the first measurement day. When the findings were examined, it was found that there was no significant difference in the 1TM strength values of the deadlift exercise in the 1st and 2nd measurement sessions (p = 0.596 ). However, a significant difference was found between the 1TM strength, Isometric back-leg strength, Counter Movement Jump (CMJ) and Squat Jump (SJ) values of the squat exercise (p = 0.003, p = 0.002, p = 0.002, p = 0.002). In conclusion, this study shows that a dynamic warm-up protocol that includes hip mobility has a positive effect on vertical jump, maximal and isometric strength parameters.

The aim of this study was to investigate the effect of vitamin E-trace mineral treatments before synchronization and PGF2α injection one day before and on the day of sponge removal on reproductive parameters in Morkaraman ewes during the breeding season. Fifteen days before the synchronization, the sheep in Group I (n=11) and Group II (n=12) were given orally capsules containing a vitamin E-mineral combination. The sheep in Group III (n=10) and IV (n=14) weren"t given. An intravaginal sponge was applied to all sheep to remain in the vagina for 6 days, and eCG was injected immediately in all groups after the sponge was removed. The sheep in Groups I and III were injected with PGF2α only on the fifth day, and the sheep in Groups II and IV were injected with PGF2α on both the fifth and sixth days. The highest rates of pregnancy (91.67%) were in Group II (P>0.05). The rate of multiple lambing was higher in Groups II (90.91%) and IV (87.5%) than in other groups (P>0.05). The lambing rate was lowest in Group III (60%, P>0.05). Embryonic mortality rates in the groups were found to be 14.29%, 9.09%, 20.00% and 12.50% in the Group I, Group II, Group III and Group IV, respectively. It was determined that litter size was 1.33, 2.3, 2.67, and 3.29 in the Group I, Group II, Group III and Group IV, respectively (P>0.05). It was determined that the average birth weight of lamb was highest in Group I (4.88±0.18 kg). It was determined that vitamin E-trace mineral treatments and double PGF2α injection increased the pregnancy rate (P>0.05), especially double PGF2α injection contributed to the formation of multiple pregnancies.

The size of the data transmitted in communication systems is constantly increasing and leads to the need for high bandwidth. Therefore, using the millimeter wave (mmWave) band is one of the best solutions in data transmission. Frequency multiplication via nonlinear components is used for signal generation at higher frequencies in the millimeter to submillimeter bands and it is of great importance in generating signals up to 2.2 THz. Although communication systems with the highest carrier frequency using these components are available at the 300 GHz-340 GHz, standard communication models do not comply with data transmission at this band, bringing problems caused by nonlinearity throughout data recovery. We solve these problems with the proposed constellation modification method, which has not been studied before. In this study, it is aimed to provide data transmission in the mmWave band with an experimental communication system that is compatible with the frequency multiplication and has high spectral efficiency. For the first time to our knowledge, a novel constellation modification method that can be modified according to the frequency multiplication on the standard M-ary phase shift keying (MPSK) data is proposed. In this method, the existing receiver structure is preserved and MPSK with harmonic modulation is carried. In the experimental demonstration part, harmonic binary shift keying (BPSK) data transmission via frequency multiplied 30 GHz transmitter was achieved with a power penalty of 2.3 dB, and this shows that MPSK data transmission over harmonic mmWave or submillimeter band sources is now possible.

Objective:This study aimed to determine the environmental stressors perceived by patients admitted to the surgical intensive care unit.Materials and Methods:This is a descriptive and cross-sectional study. The sample of the study comprised 83 patients hospitalized in the surgical intensive care unit. Data were obtained from the Patient Information Form and the Intensive Care Unit Environmental Stressor scale.Results:Patients hospitalized in the surgical intensive care unit identified the most critical stressors as experiencing pain, inability to sleep, lack of privacy, getting bored, and short family and friends visit time, whereas the minor stressful factors were identified as hearing phone sounds, nurses who are more concerned with bedside devices than the patients, and constantly looking at the ceiling.Conclusion:Environmental stressors affecting patients in the intensive care unit should be identified and eliminated. This initiative will prevent new stress-related health problems and improve patient quality care.

Objective: To evaluate the consistency of the urinalysis results performed with the ORUBA INALYS device, (Oruba, Ankara, Turkey) which can perform urinalysis and uroflowmetry simultaneously, with the analysis results performed with the SYSMEX UC3500 automated urine chemistry analyzer (Sysmex, Kobe, Japan). Material and methods: In this prospective study, urinalysis of 50 male patients with lower urinary tract symptoms were evaluated. The parameters of glucose, pH, urobilinogen, bilirubin and ketone, leukocyte, protein, and blood were measured with ORUBA INALYS, and the same urine specimens collected from ORUBA INALYS by a special setup were sent to the laboratory for urinalysis with Sysmex UC-3500 to assess the concordance of the results between two devices. Results: Urinalysis results in ORUBA INALYS device in terms of glucose, pH, urobilinogen, bilirubin, and ketone parameters were shown to achieve 100% agreement within ±1 category with SYSMEX UC3500 whereas these values were slightly decreased to 88%, 96%, and 98% for leukocyte, protein, and blood, respectively. Among the calculable weighted kappa values for the test parameters, the highest value was found for glucose and followed by blood, pH, leukocyte, and specific gravity respectively. Conclusion: Significant consistency of the urinalysis results obtained from ORUBA INALYS with those obtained from device SYSMEX UC3500 shows the reliability of the urinalysis performed with ORUBA INALYS. ORUBA INALYS could minimize costs and workload, provide time save and reduce plastic waste.

Although transcatheter aortic valve implantation (TAVI), which is a less invasive standard treatment for aortic stenosis than surgery, has been recommended even in low-risk patients, its effectiveness in bicuspid aortic valve is still unclear. Cardiac surgery has been proven to cause serious complications in hematological diseases with factor deficiency or bleeding diathesis. In this case, which is the first in the literature to our knowledge, we tried to present the successful TAVI procedure in a young patient with bicuspid aortic stenosis and factor 7, 11 deficiency complicated by atrial fibrillation.

Abstract Various environmental drivers influence life processes of insect vectors that transmit human disease. Life histories observed under experimental conditions can reveal such complex links; however, designing informative experiments for insects is challenging. Furthermore, inferences obtained under controlled conditions often extrapolate poorly to field conditions. Here, we introduce a pseudo-stage-structured population dynamics model to describe insect development as a renewal process with variable rates. The model permits representing realistic life stage durations under constant and variable environmental conditions. Using the model, we demonstrate how random environmental variations result in fluctuating development rates and affect stage duration. We apply the model to infer environmental dependencies from the life history observations of two common disease vectors, the southern (Culex quinquefasciatus) and northern (Culex pipiens) house mosquito. We identify photoperiod, in addition to temperature, as pivotal in regulating larva stage duration, and find that carefully timed life history observations under semi-field conditions accurately predict insect development throughout the year. The approach we describe augments existing methods of life table design and analysis, and contributes to the development of large-scale climate- and environment-driven population dynamics models for important disease vectors.

Aim:In the case of hypoxia, despite the definite benefit of oxygen (O2) administration, there is controversial evidence regarding the risk/benefit balance of high concentration O2 inhalation during surgery as a precaution in those not previously hypoxic. The purpose of this study was to determine the effect of inspiratory O2 (FiO2) administered at different concentrations on oxidative stress during general anesthesia.Methods:This randomized prospective study was conducted from February to May 2021. According to intraoperative FiO2, the patients were divided into two groups: 50% FiO2 (group 1) and 30% FiO2 (group 2). Blood samples taken before preoxygenation and at the end of surgery were used to assess arterial partial O2 pressure (PaO2), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI).Results:The study was completed with 40 patients. Intragroup plasma TOS, OSI, and PaO2 levels increased significantly at the end of surgery (group 1 p=0.003, 0.003,

INTRODUCTION: We compared prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, and Ddimer test results measured using the Diagon Coag XL coagulation analyzer with Cobas t 511 analyzer. METHODS: Imprecision studies were performed for the PT, aPTT, fibrinogen, and D-dimer tests used by the Diagon Coag XL analyzer. For the comparison study, we used the leftover citrated plasma from patient samples after routine analysis with Cobas t 511. All of the results were analyzed using the correlation coefficient and Passing–Bablok regression analysis. RESULTS: Total coefficient of variation obtained for all tests were within the criteria for acceptance. The method comparison study showed a good correlation between the results obtained on Diagon Coag XL and Cobas t 511 analyzers, except for aPTT test. The correlation coefficients obtained were 0.98 for PT, INR, and D-dimer, 0.95 for fibrinogen, and 0.80 for aPTT. DISCUSSION AND CONCLUSION: For PT, aPTT, fibrinogen, and D-dimer tests, Diagon Coag XL analyzer is suitable for monitoring the coagulation system, and it can be used in clinical laboratories. However, the precision values of tests stated by the manufacturer must be verified.

We propose a novel strategy for incorporating hierarchical supervised label information into nonlinear dimensionality reduction techniques. Specifically, we extend t-SNE, UMAP, and PHATE to include known or predicted class labels and demonstrate the efficacy of our approach on multiple single-cell RNA sequencing datasets. Our approach, "Haisu," is applicable across domains and methods of nonlinear dimensionality reduction. In general, the mathematical effect of Haisu can be summarized as a variable perturbation of the high dimensional space in which the original data is observed. We thereby preserve the core characteristics of the visualization method and only change the manifold to respect known or assumed class labels when provided. Our strategy is designed to aid in the discovery and understanding of underlying patterns in a dataset that is heavily influenced by parent-child relationships. We show that using our approach can also help in semi-supervised settings where labels are known for only some datapoints (for instance when only a fraction of the cells are labeled). In summary, Haisu extends existing popular visualization methods to enable a user to incorporate labels known a priori into a visualization, including their hierarchical relationships as defined by a user input graph.

ÖZ: Ticaret, insan hayatında uzun süredir var olan alanlardan biridir. Geçmişten günümüze iletişim ve teknoloji alanlarında yaşanan gelişmeler, ticaret için de farklı zeminler oluşmasını sağlamıştır. Sosyal medya platformları ile ticaret faaliyetlerinin kesiştiği noktada ortaya çıkan sosyal ticaret alanı için günümüzün gelişmekte olan yeni ticaret ortamlarından biri konumundadır. Bu çalışmada, bankacılık sektörü çalışanlarının sosyal ticaret üzerine ilgileri demografik özellikler üzerinden karşılaştırılarak incelenmektedir. Kullanıcılardan veri toplama aşamasında anket yöntemi tercih edilmiştir. Pilot çalışmada 81 banka personeli çalışmaya katılmıştır. Pilot çalışmanın ardından bankacılık sektörü çalışanlarına yönelik olarak 402 katılımcı anket formundaki ifadeleri yanıtlamıştır. Toplanan yanıtlar üzerinde faktör analizi yapılmış ve genel ilgi dışında beş farklı ilgi başlığı belirlenmiştir. Yapılan analizler sonucunda beş farklı ilgiye göre katılımcıların demografik özellikleri arasındaki farklılıklar incelenmiştir. Çalışma sonucunda; genç katılımcıların sosyal ticaret ilgilerinin diğer demografik özelliklerdeki katılımcılara göre daha yüksek olduğu sonucuna ulaşılmıştır. Ayrıca cinsiyet özelliği açısından yapılan karşılaştırmalarda kadın katılımcıların sosyal ticaret faaliyetlerine daha fazla ilgi gösterdikleri belirlenmiştir. ABSTRACT: Trade is one of the long-standing fields in human life. Developments in the fields of communication and technology from the past to the present have created different grounds for trade. Social commerce is one of the developing new trade environments of today that emerges at the intersection of social media platforms and commercial activities. In this study, the interests of the banking sector employees on social trade are examined by comparing based on demographic characteristics. Survey method was preferred for data collection from participants. In the pilot study, 81 bank staffs participated in the study. Following the pilot study, Following the pilot study, 402 participants answered the questions in the questionnaire developed for banking sector employees. Factor analysis was performed on the responses and five different interest topics were identified in addition to general interest. As a result of the analyzes, the differences between the demographic characteristics of the participants were examined according to the five different interests. As a result of this study, it was concluded that the social commerce interests of young participants were higher than those of other demographic characteristics. Furthermore, it was also concluded that female participants have more interest to social commerce activities in terms of gender characteristics.

Background and Aim: Many metabolic and immunological changes occur during the transition period. Innate immunity plays an important role against to infections and natural antibodies (NAb) are important in immunity. This study aims to determine a connection between serum NAb titers, beta-hydroxybutyric acid (BHBA), and non-esterified fatty acid (NEFA) concentrations in Tuj and Hemsin sheep during the peripartum period. Materials and Methods: Serum NAb, BHBA, and NEFA levels were determined from the blood samples collected from Tuj and Hemsin sheep on days 30 and 15 before birth, on the day of birth (day 0), and on days 15 and 30 after birth. Results: NAb titers were found to be higher in Tuj than in Hemsin sheep (p0.05). The serum NEFA level was lower in Tuj sheep in the last 15 days of pregnancy compared to Hemsin sheep (p

Abstract Qudit entanglement is an indispensable resource for quantum information processing since increasing dimensionality provides a pathway to higher capacity and increased noise resilience in quantum communications, and cluster-state quantum computations. In continuous-variable time–frequency entanglement, encoding multiple qubits per photon is only limited by the frequency correlation bandwidth and detection timing jitter. Here, we focus on the discrete-variable time–frequency entanglement in a biphoton frequency comb (BFC), generating by filtering the signal and idler outputs with a fiber Fabry–Pérot cavity with 45.32 GHz free-spectral range (FSR) and 1.56 GHz full-width-at-half-maximum (FWHM) from a continuous-wave (cw)-pumped type-II spontaneous parametric downconverter (SPDC). We generate a BFC whose time-binned/frequency-binned Hilbert space dimensionality is at least 324, based on the assumption of a pure state. Such BFC’s dimensionality doubles up to 648, after combining with its post-selected polarization entanglement, indicating a potential 6.28 bits/photon classical-information capacity. The BFC exhibits recurring Hong–Ou–Mandel (HOM) dips over 61 time bins with a maximum visibility of 98.4% without correction for accidental coincidences. In a post-selected measurement, it violates the Clauser–Horne–Shimony–Holt (CHSH) inequality for polarization entanglement by up to 18.5 standard deviations with an S-parameter of up to 2.771. It has Franson interference recurrences in 16 time bins with a maximum visibility of 96.1% without correction for accidental coincidences. From the zeroth- to the third-order Franson interference, we infer an entanglement of formation (E of) up to 1.89 ± 0.03 ebits—where 2 ebits is the maximal entanglement for a 4 × 4 dimensional biphoton—as a lower bound on the 61 time-bin BFC’s high-dimensional entanglement. To further characterize time-binned/frequency-binned BFCs we obtain Schmidt mode decompositions of BFCs generated using cavities with 45.32, 15.15, and 5.03 GHz FSRs. These decompositions confirm the time–frequency scaling from Fourier-transform duality. Moreover, we present the theory of conjugate Franson interferometry—because it is characterized by the state’s joint-temporal intensity (JTI)—which can further help to distinguish between pure-state BFC and mixed state entangled frequency pairs, although the experimental implementation is challenging and not yet available. In summary, our BFC serves as a platform for high-dimensional quantum information processing and high-dimensional quantum key distribution (QKD).

XIX. yüzyıl bestekârlarından Sermüezzin Rifat Bey farklı makamlarda ve çeşitli formlarda eserler bestelemiştir. Tanzimat dönemi bestekârı olan Rifat Bey, Batılılaşma akımının getirdiği değişikliklere ayak uydurmuştur. Türk mûsikîsi ile Batı müziği alanında yaptığı eserler, her iki alan için de önem teşkil etmektedir. Bu çalışmada, Sermüezzin Rifat Bey’in hicâzkâr makamında notası tespit edilen 22 adet eserindeki usûl-arûz vezni ilişkisi incelenmiştir. Eserler içerisinde kullanılan arûz vezinlerinin, benzerlikleri ve farklılıkları tespit edilmiştir. Elde edilen sonuçlar ışığında güftelerin, müzik cümleleri ve usûller ile uyum içerisinde şekillendiği görülmüştür.

Bone drilling is a common method for fixing implants used in bone fractures. Because of the fibre-reinforced composite structure of bone, parameters such as feed rate, spindle speed and drill type affect the hole surface quality. After drilling, the quality of the bore surface, burr formation and delamination at the hole entrance and exit affect the ability of the screw to cause implant failure and fusion problems of the fracture. For this reason, it is very important to conduct drilling with optimum speed and feedrate values. In this study, the effects of processing parameters on hole surface quality and delamination were studied experimentally. In the experiment, bovine bone, which has similar structural properties to human bone, was used. The hole surface quality and delamination formed at the exit of the hole were examined for three different feed rates and spindle speeds. As a result of the experiments, it was seen that the feed rate had more effect on both delamination and hole surface quality than the spindle speed. It was also determined that the cortical part of the bone and the cancellous part of the bone affected the production of heat and drill wear differently.

Objective: Vitamin D deficiency has been shown to be associated with coronary artery disease (CAD). In addition, there are studies suggesting that hyperuricemia is an independent risk factor for atherosclerosis, whereas the relationship between the combination of these 2 parameters and severity of CAD remains unclear. The aim of this study was to investigate the association between the combination of vitamin D deficiency and hyperuricemia and the extent of CAD. Methods: A total of 502 patients who had experienced myocardial infarction (MI) were included in this cross-sectional study. The 25-hydroxyvitamin D (25OHD) and serum uric acid (SUA) levels were measured in blood samples taken at the time of admission. A 2x2 factorial design was used to create groups according to the presence of hyperuricemia (>7 mg/dL) and vitamin D deficiency (

Norepinephrine is a key sympathetic neurotransmitter, which acts to suppress CD8 + T cell cytokine secretion and lytic activity by signaling through the β2-adrenergic receptor (ADRB2). Although ADRB2 signaling is considered generally immunosuppressive, its role in regulating the differentiation of effector T cells in response to infection has not been investigated. Using an adoptive transfer approach, we compared the expansion and differentiation of wild type (WT) to Adrb2-/- CD8 + T cells throughout the primary response to vesicular stomatitis virus (VSV) infection in vivo. We measured the dynamic changes in transcriptome profiles of antigen-specific CD8 + T cells as they responded to VSV. Within the first 7 days of infection, WT cells out-paced the expansion of Adrb2-/- cells, which correlated with reduced expression of IL-2 and the IL-2Rα in the absence of ADRB2. RNASeq analysis identified over 300 differentially expressed genes that were both temporally regulated following infection and selectively regulated in WT vs Adrb2-/- cells. These genes contributed to major transcriptional pathways including cytokine receptor activation, signaling in cancer, immune deficiency, and neurotransmitter pathways. By parsing genes within groups that were either induced or repressed over time in response to infection, we identified three main branches of genes that were differentially regulated by the ADRB2. These gene sets were predicted to be regulated by specific transcription factors involved in effector T cell development, such as Tbx21 and Eomes. Collectively, these data demonstrate a significant role for ADRB2 signaling in regulating key transcriptional pathways during CD8 + T cells responses to infection that may dramatically impact their functional capabilities and downstream memory cell development.

Deterministic positioning single site-controlled high symmetric InGaAs quantum dots (QDs) in (111)B-oriented GaAs photonic crystal cavities with nanometer-scale accuracy provides an idea component for building integrated quantum photonic circuits. However, it has been a long-standing challenge of improving cavity Q -factors in such systems. Here, by optimizing the trade-off between the cavity loss and QD spectral quality, we demonstrate our site-controlled QD-nanocavity system operating in the intermediate coupling regime mediated by phonon scattering, with the dynamic coexistence of strong and weak coupling. The cavity-exciton detuning-dependent micro-photoluminescence spectrum reveals concurrence of a trend of exciton-polariton mode avoided crossing, as a signature of Rabi doublet of the strongly coupled system. Meanwhile, a trend of keeping constant or slight blue shift of coupled exciton–cavity mode(CM) energy across zero-detuning is ascribed to the formation of collective states mediated by phonon-assisted coupling, and their rare partial out-of-synchronization linewidth-narrowing is linked to their coexisting strong-weak coupling regime. We further reveal the pump power-dependent anti-bunching photon statistical dynamics of this coexisting strong-weak coupled system and the optical features of strongly confined exciton-polaritons, and dark-exciton-like states. These observations demonstrate the potential capabilities of site-controlled QD-cavity systems as deterministic quantum nodes for on-chip quantum information processing and provide guidelines for future device optimization for achieving the strong coupling regime.

Bu çalışma, farklı NaCl konsantrasyonlarının bazı şeker mısır (Zea mays L. sacharata sturt.) çeşitlerinin çimlenme ve erken fide gelişimi üzerine etkisini belirlemek amacıyla yürütülmüştür. Çalışmada Vega F1 (sh2), Merit F1 (su) ve Tanem F1 (su) çeşitlerinin tohumlarına 0 (kontrol), 2, 4, 6, 8 ve 10 dSm -1 konsantrasyonlarında NaCl uygulanmıştır. Tohum ekiminden 5 gün sonra çeşitlerin çimlenme oranı, 12 gün sonra kök uzunluğu, gövde uzunluğu, kök gövde oranı, kök kuru madde oranı, gövde kuru madde oranı, fide gücü indeksi ve tuz toleransı ölçümleri yapılmıştır. Araştırmada incelenen karakterler arasında istatistiki açıdan önemli farklılıklar tespit edilmiştir. Sonuç olarak; farklı tuz konsantrasyonlarına çeşitler tuz oranı artıkça çimlenme oranı ve fide gelişimi özelliklerinin azaldığı tespit edilmiştir. Tanem F1 çeşit çimlenme oranı ve tuz stresine toleransı bakımından en yüksek değerlere sahipken kök ve gövde uzunluğu ve kök gövde oranı bakımından ise en düşük değerlere sahip olduğu tespit edilmiştir. Fide gücü indeksi bakımından ise sırasıyla Vega F1, Tanem F1 ve Merit F1 olduğu belirlenmiştir. Çalışmada yapılan korelasyon sonuçlarına göre, incelenen parametreler arasında istatistiki açıdan pozitif yönde önemli farklılıklar tespit edilmiştir. Çimlendirme ortamından 2 dSm-1 tuzluluk düzeyine kadar tohum çimlenmesi ve erken fide gelişim parametrelerinin etkilenmezken 2 dSm-1 yüksek düzeylerde ise olumsuz yönde etkilendiği belirlenmiştir. Yetiştiricilik yapılan bölgelerde 2 dSm-1 tuzluluk düzeyine kadar suların, şeker mısır çimlenme ve erken fide gelişim dönemlerinde kullanılabileceği tespit edilmiştir.

Kurumsal şirketlerde, yazılımlardaki hatalar ve değişiklik talepleri genellikle bir talep yönetim sistemi üzerinden Bilgi Teknolojileri (BT) birimine iletilir. Bu sistemde yer alan öncelik bilgisi BT birimi için kritik öneme sahiptir. Ancak, talebi giren kişilerin inisiyatifine bırakılan öncelik kararı her zaman gerçekçi olmamaktadır. Örneğin, kritik olmayan ve düşük öncelikli bir değişiklik talebi yüksek öncelikli olarak girilebilmekte, bu da hatalı planlama ve müşteri memnuniyetsizliği ile sonuçlanabilmektedir. Bu çalışmada, iç müşteri talepleri metin madenciliği yöntemleriyle sınıflandırılarak taleplerin önem derecesi tahmin edilmeye çalışılmıştır. Sistemin eğitimi ve testi için kurumsal bir şirketin talep yönetim sisteminden alınan kayıtlar kullanılmıştır. Ham metin formundaki talep verisi üzerinde temizlik ve önişleme işlemlerinin ardından, doküman-terim matrisinin oluşturulmasında TF-IDF (Terim Frekansı – Ters Doküman Frekansı) ağırlıklandırma yönteminden yararlanılmıştır. Oluşturulan veri seti üzerinde çeşitli sınıflandırma algoritmaları test edilmiş ve en yüksek başarım %54.1 F-Skoru ile Sequential Minimal Optimization algoritmasıyla elde edilmiştir. Ayrıca, aşırı örnekleme yoluyla sınıfların dengeli hale getirildiği veri seti üzerinde ise en yüksek başarıma %74.5 F-Skoru değeri ile Random Forest algoritmasıyla ulaşılmıştır.

Kurumsal şirketlerde, yazılımlardaki hatalar ve değişiklik talepleri genellikle bir talep yönetim sistemi üzerinden Bilgi Teknolojileri (BT) birimine iletilir. Bu sistemde yer alan öncelik bilgisi BT birimi için kritik öneme sahiptir. Ancak, talebi giren kişilerin inisiyatifine bırakılan öncelik kararı her zaman gerçekçi olmamaktadır. Örneğin, kritik olmayan ve düşük öncelikli bir değişiklik talebi yüksek öncelikli olarak girilebilmekte, bu da hatalı planlama ve müşteri memnuniyetsizliği ile sonuçlanabilmektedir. Bu çalışmada, iç müşteri talepleri metin madenciliği yöntemleriyle sınıflandırılarak taleplerin önem derecesi tahmin edilmeye çalışılmıştır. Sistemin eğitimi ve testi için kurumsal bir şirketin talep yönetim sisteminden alınan kayıtlar kullanılmıştır. Ham metin formundaki talep verisi üzerinde temizlik ve önişleme işlemlerinin ardından, doküman-terim matrisinin oluşturulmasında TF-IDF (Terim Frekansı – Ters Doküman Frekansı) ağırlıklandırma yönteminden yararlanılmıştır. Oluşturulan veri seti üzerinde çeşitli sınıflandırma algoritmaları test edilmiş ve en yüksek başarım %54.1 F-Skoru ile Sequential Minimal Optimization algoritmasıyla elde edilmiştir. Ayrıca, aşırı örnekleme yoluyla sınıfların dengeli hale getirildiği veri seti üzerinde ise en yüksek başarıma %74.5 F-Skoru değeri ile Random Forest algoritmasıyla ulaşılmıştır.

Abstract Background The purpose of this study was to investigate gingival crevicular fluid (GCF) and serum folate-receptor 1 (FOLR1) levels in subjects with different periodontal status. Methods The study consists of three groups: Healthy group (n = 15), gingivitis group (n = 15) and chronic periodontitis group (n = 15). Clinical periodontal parameters including probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI) and bleeding on probing (BOP) were assessed. GCF and serum samples were collected from each patient and were analyzed FOLR1 levels by enzyme-linked immunosorbent assay. Results The values of FOLR1 in GCF were higher in gingivitis and periodontitis groups than among patient in control group (p

Abstract Background Every biological experiment requires a choice of throughput balanced against physiological relevance. Most primary drug screens neglect critical parameters such as microenvironmental conditions, cell-cell heterogeneity, and specific readouts of cell fate for the sake of throughput. Methods Here we describe a methodology to quantify proliferation and viability of single cells in 3D culture conditions by leveraging automated microscopy and image analysis to facilitate reliable and high-throughput measurements. We detail experimental conditions that can be adjusted to increase either throughput or robustness of the assay, and we provide a stand alone image analysis program for users who wish to implement this 3D drug screening assay in high throughput. Results We demonstrate this approach by evaluating a combination of RAF and MEK inhibitors on melanoma cells, showing that cells cultured in 3D collagen-based matrices are more sensitive than cells grown in 2D culture, and that cell proliferation is much more sensitive than cell viability. We also find that cells grown in 3D cultured spheroids exhibit equivalent sensitivity to single cells grown in 3D collagen, suggesting that for the case of melanoma, a 3D single cell model may be equally effective for drug identification as 3D spheroids models. The single cell resolution of this approach enables stratification of heterogeneous populations of cells into differentially responsive subtypes upon drug treatment, which we demonstrate by determining the effect of RAK/MEK inhibition on melanoma cells co-cultured with fibroblasts. Furthermore, we show that spheroids grown from single cells exhibit dramatic heterogeneity to drug response, suggesting that heritable drug resistance can arise stochastically in single cells but be retained by subsequent generations. Conclusion In summary, image-based analysis renders cell fate detection robust, sensitive, and high-throughput, enabling cell fate evaluation of single cells in more complex microenvironmental conditions.

BACKGROUND/AIM: Vascular endothelial growth factor (VEGF) is a major cytokine in angiogenesis and has a role on aggressivity of various tumors. The expression of VEGF has been shown to increase in differential thyroid cancer. The aim of the study was to evaluate serum and intranodular VEGF (nVEGF) and VEGF receptor-1 (VEGFR-1) levels in patients with thyroid nodules and their relevance to ultrasonographic and pathological results. MATERIALS AND METHODS: A total of eighty patients were included in the study. Thyroid fine-needle aspiration biopsies were performed, and the levels of serum and nVEGF and VEGFR-1 were measured. Any possible correlations between serum and nVEGF, VEGFR-1, and biochemical/radiological variables were investigated. RESULTS: There were no significant differences between serum VEGF (sVEGF), nVEGF, sVEGFR-1, nVEGFR-1 levels, number of nodules, size of nodules, and benign and malignant ultrasonographic features. sVEGF and nVEGF were higher in malignant or suspicious nodules than that in benign nodules, but did not reach statistical significance (P > 0.05). sVEGFR-1 and nVEGFR-1 levels were higher in hyperthyroid patients than that in euthyroid patients (P < 0.05 and P = 0.003, respectively). nVEGFR-1 level was higher in hypothyroid patients than that in euthyroid patients (P = 0.016). sVEGF level was found to be higher in hyperactive nodules than that in others. Both sVEGFR-1 (P = 0.008) and nVEGF levels (P = 0.01) significantly increased with increasing age. nVEGFR-1 decreased with increasing body mass index (BMI) (P = 0.004). CONCLUSIONS: Our study showed the relationships of sVEGF, nVEGF, sVEGFR-1, and nVEGFR-1 levels with age, gender, BMI, and hyperthyroidism. To determine the role of VEGF/VEGFR-1 in thyroid nodules, further studies are required with a large number of patients.

Background. In peritoneal carcinomatosis (PC), increased life span and disease-free survival times are shown in patients with hyperthermic intraperitoneal chemotherapy (HIPEC) and early postoperative intraperitoneal chemotherapy (EPIC) following cytoreductive surgery (SRC). In this study, our main objective was to present our experience of performing SRC and perioperative intraperitoneal chemotherapy (HIPEC and EPIC) on patients with PC, in light of the literature. Methods. Demographic data, follow-up results, peritoneal carcinomatosis index (PCI), completeness of cytoreduction (CCR) score, and morbidity and mortality rates of 180 patients treated with SRC + HIPEC + EPIC for PC at the Department of Surgical Oncology at Sivas Cumhuriyet University between January 2008 and July 2020 were analyzed retrospectively. Results. Distribution of 180 PC cases according to primary organs included 53 ovarian, 39 colorectal, 33 stomach, 25 primary peritoneum, 10 uterus, 10 tuba, five soft tissue, and five appendix originated carcinoma. The average PCI of the cases detected preoperatively was 21 (5–30). Completeness of cytoreduction scores of CCR-0 in 102 cases, CCR-1 in 67 cases, CCR-2 in eight cases, and CCR-3 in three cases was obtained. Median operation time was 300 (200–540) minutes. Perioperative morbidity rate was 47.0%, and perioperative mortality rate was 13.5%. Conclusion. The peritonectomy procedure is a difficult, long-lasting, troublesome intervention, but it is the most important treatment option with acceptable morbidity and mortality rates in patients selected for PC treatment in experienced centers.

Mental rotation (MR) is a cognitive skill whose neural dynamics are still a matter of debate as previous neuroimaging studies have produced controversial results. In order to investigate the underlying neurophysiology of MR, hemodynamic responses from the prefrontal cortex of 14 healthy subjects were recorded with functional near-infrared spectroscopy (fNIRS) during a novel MR task that had three categorical difficulty levels. Hemodynamic activity strength (HAS) parameter, which reflects the ratio of brain activation during the task to the baseline activation level, was used to assess the prefrontal cortex activation localization and strength. Behavioral data indicated that the MR requiring conditions are more difficult than the condition that did not require MR. The right dorsolateral prefrontal cortex (DLPFC) was found to be active in all conditions and to be the dominant region in the easiest task while more complex tasks showed widespread bilateral prefrontal activation. A significant increase in left DLPFC activation was observed with increasing task difficulty. Significantly higher right DLPFC activation was observed when the incongruent trials were contrasted against the congruent trials, which implied the possibility of a robust error or conflict-monitoring process during the incongruent trials. Our results showed that the right DLPFC is a core region for the processing of MR tasks regardless of the task complexity and that the left DLPFC is involved to a greater extent with increasing task complexity, which is consistent with the previous neuroimaging literature.

The present study was performed to demonstrate the tissue differentiation of uterine ultrasonographic image by computer assisted analysis programs in mares with endometrial cyst and early pregnancy. A total of 124 thoroughbred Arabian mares were used in the study, with early pregnancy and endometrial cyst. Mares were divided into six groups according to stage of early pregnancy (Group I, n=12 (13th day pregnancy); Group II, n=15 (14th day pregnancy); Group III, n=29 (15th day pregnancy); Group IV, n=17 (16th day pregnancy); Group V, n=12 (17th day pregnancy)) and as endometrial cysts (Group VI, n=39). The mean gray value (MGV), heterogeneity (HET) and contrast (CON) of the uterine images that were recorded during ultrasound scan were measured through computer assisted program. The MGV values of the echotexture parameters were significantly higher in the pregnant mare (55.20±4.95, 58.31±3.88, 56.23±1.88, 54.15±3.47 and 56.08±2.94, respectively) than the endometrial cyst mares (42.71±0.71) (P

Aim: The aim of this study was to evaluate the protective use of quercetin in a rat model of radiation-induced enteritis and colitis. Methods: Twenty four adult rats were randomly divided into four groups. Group SHAM was given only physiological saline, group QUER was given quercetin 50 mg/kg for 15 days, group RAD was given only irradiation and group QUER+RAD was given quercetin 50 mg/kg, and then irradiated. Twenty four hours after the exposure to radiation, all rats were euthanized for the evaluation of the ileum and colon morphology and biochemical measurements. Results: Compared with the SHAM group, the serum malondialdehyde (MDA) level was significantly higher in group RAD (p=0.004) and was significantly decreased in group QUER+RAD (p=0.015). The MDA levels in the ileum and colon tissues were significantly higher in group RAD (p=0.004 and p=0.002, respectively), while treatment with quercetin significantly reduced lipid peroxidation in both tissues in group QUER+RAD (p=0.015 and p=0.009, respectively). Compared with the control group, the serum total antioxidant status (TAS) level was significantly lower in Group RAD (p=0.002) and was significantly increased in group QUER+RAD (p=0.009). TAS in the ileum and colon tissues were significantly lower in group RAD (p=0.002 and p=0.002) and were significantly higher in both tissues in group QUER+RAD (p=0.002 and p=0.002, respectively). Conclusion: This study confirmed that, in the model of radiation-induced ileitis and colitis in rats, quercetin effectively decreased oxidative stress and inflammatory damage to both ileum and colon tissues.

Introduction and Aim: Sarcoidosis increases inhomogeneity in ventricular repolarization due to the presence of sarcoid granuloma, which significantly correlates with ventricular fibrillation. Various studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (T-peak to T-end [Tpe] interval) may correspond to the transmural dispersion of repolarization and that increased Tpe interval and Tpe/QT ratio are associated with malignant ventricular arrhythmias. The present study hypothesized that QT and Tpe intervals are significantly prolonged in sarcoidosis patients without apparent cardiac involvement. Methods: The study population consisted of 54 patients (37 female; mean age 43.4±10.6 years) under follow-up for sarcoidosis and 56 healthy subjects (37 female; mean age 42.4±8.6 years). Results: There was no statistically significant difference between the groups in maximum QT interval, QT dispersion or corrected QT (QTc) interval, but QTc dispersion and Tpe interval were significantly prolonged in the sarcoidosis group compared to the control group (QTc dispersion 59.9±22.5 and 44.4±23.8, respectively, p=0.001; Tpe interval 79.4±9.3 and 70.7±7.03, respectively, p

Adaylık eğitimi kısaca öğretmenlerin resmi olarak bir okula atanmalarıyla başlayan mesleki gelişim sürecidir. Bu süreçte öğretmenler sınıflarını, diğer öğretmenleri, okullarını, okul içinde yer alan süreçleri tanırken örgütsel ve mesleki bağlılık geliştirler. Bu nedenle öğretmenlerin mesleğini benimsemelerinde ve etkili bir öğretmenlik yaşamı oluşturmalarında adaylık dönemi önemli bir aşamayı oluşturur. Bu çalışmanın temel amacı aday öğretmenlerin mesleğe uyum sürecinde yaşadıkları deneyimleri yine öğretmenlerin bakış açılarıyla ortaya koymaktır. Çalışmada nitel araştırma yöntemi kullanılmış ve verilerin çözümlenmesinde içerik analizi kullanılmıştır. Veriler Çanakkale’de 2016 yılında lise ve ortaokulda göreve başlayan dört aday branş öğretmenine Aday Öğretmelerin Mesleğe Uyum Süreci adlı yarı yapılandırılmış görüşme formu uygulanarak elde edilmiştir. Araştırmada aday öğretmenlerin görüşleri doğrultusunda aday öğretmenlikte mesleğe uyum sürecinde bürokratik işlemlerde yaşanan zaman kaybı haricinde rehber/danışman öğretmen uygulaması katkısıyla etkin ve nitelikli bir program uygulandığı sonucuna ulaşılmıştır.

Summary– Transcatheter aortic valve replacement (TAVR) was designed to treat elderly patients with severe aortic stenosis at high risk for surgery, and is most commonly performed with retrograde approach through femoral arteries. However, in up to 30% of cases, it is either not possible to use this access route or it is considered to have high risk of vascular injury. Alternative approaches have been described for patients with no suitable femoral access: trans-subclavian, transaortic, or direct aortic access; however, since the introduction of new valves deployed with low-profile delivery systems, another alternative transcatheter approach has been discovered. Presently described is experience in 2 cases in which patients were treated with transfemoral TAVR using Edwards SAPIEN 3 transcatheter heart valves immediately following ipsilateral common iliac artery stenting.

Levetiracetam (LEV) is a newer second-generation antiepileptic drug that is found to be effective in tonic-clonic seizures, partial onset seizures, and myoclonic seizures. Among antiepileptic drugs, LEV is usually known for fewer adverse drug reactions. Psychiatric disorders after the administration of LEV have been reported in the literature. There are many case reports on LEV-induced psychosis, but there are only three case reports of mania induced by LEV use. In this report, we present a case with no history of psychiatric disorder who had a hypomania episode after receiving LEV for epilepsy treatment. The development of manic symptoms with LEV therapy is unusual. Clinicians should consider monitoring patients closely for treatment-related psychological symptoms and psychotic symptoms, including the possibility of mania.

Objective. Sulphur, similar to phosphorus, is easily attached to organic compounds. The inadequate elimination of sulphate may cause high sulphate concentrations in hemodialysis (HD) patients because sulphate is low in free form in plasma. Although we are well aware of the accumulation of phosphorus in chronic dialysis patients, we do not have an adequate knowledge database about the sulphur compounds. This study was designed to determine the level of sulphate in hemodialysis patients. Materials and Methods. Ninety-four prevalent HD patients and 33 patients without renal failure were included in the study. The serum inorganic sulphate levels were measured by turbidimetric technique. Moreover, the serum level of urea, creatinine, albumin, calcium, phosphorus, and parathyroid hormone concentrations was simultaneously recorded. Results. Mean levels of plasma sulphate were significantly higher (0.56 ± 0.17 mM vs 0.31 ± 0.13 mM, p