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In this paper, a novel 30 V fully isolated n-channel lateral DMOS (nLDMOS) with low specific on-resistance (RON,sp) is proposed and experimentally realized using 0.35 µm Bipolar-CMOS-DMOS (BCD) process. We optimized the process parameters, such as doping concentration of the high-voltage drift n-well (HVNW) layer, P-buried layer (PBL) and pre deep n-well (Pre-DNW) layer, for achieving a superior tradeoff between high breakdown voltage (BV) and the low RON,sp. The proposed nLDMOS is fully isolated from the substrate to support negative bias to drain and has a very lower RON,sp than other competitors in the similar technology, which is critical for devices used in high-voltage, high-current switching applications such as HVIC's. The fabricated device exhibits a BV of 42 V with RON,sp as low as 15 mohm-mm2 . Besides, the new structure is fully compatible with standard 0.35 µm BCD technology, with a margin of up to 15% in process variation, which is large enough to meet the industrial requirement for mass production. Hence, it is not only high performance but also a low-cost solution. Keywords: nLDMOS, Substrate current, 0.35 µm BCD technology, Specific on-resistance (RON,sp), Breakdown voltage (BV)

Axolotls (Ambystoma mexicanum) may heal their skin wounds scar-free in both paedomorphs and metamorphs. In previous studies on small punch skin wounds, rapid re-epithelialisation was noted in these two axolotl morphs. However, large wound size in mammals may affect wound healing. In this study, large circumferential full thickness excision wounds on the hind limbs were created on juvenile paedomorphic and metamorphic axolotls. The results showed re-epithelialisation was more quickly initiated in paedomorphs than in metamorphs after wounding. The migrating rate of epidermis on the wound bed was faster in paedomorphs than in metamorphs and thus completion of re-epithelialisation was faster in paedomorphs than in metamorphs. Within these re-epithelialisation periods, neither basement membrane nor dermis was reformed. Epidermal cell proliferation was detected by EdU-labelling technique. In the normal unwounded skin, epidermal proliferation rate was higher in paedomorphs than in metamorphs. After wounding, the epidermal proliferation rate was significantly lower in the migrating front on the wound bed than in the normal skin in paedomorphs. The EdU-labelling rate between normal skin and migration front was not different in metamorphs. Lacking of more proliferating epidermal cells on the wound bed indicated that the new epidermis here derived rather from migrating epidermal cells than from cell proliferation in situ. In conclusion, re-epithelialisation in the large wound might be fully completed in both morphs despite it was initiated earlier and with faster rate in paedomorphs than in metamorphs. The new epidermis on the wound bed derived mainly from cell migration than by cell proliferation in the re-epithelialisation period. J. Morphol. 278:228-235, 2017. © 2016 Wiley Periodicals,Inc.

Differential bevel gear strength calculation, The main purpose is to evaluate whether the gear can meet the strength and life requirements under load; There is a mature theoretical gear strength calculation formula, However, due to the theoretical gear strength calculation, the tooth shape is different from the actual tooth shape, In turn, the theoretical calculation strength is different from the actual manufacturing strength. This research is based on existing products in the industry, Calculate the theoretical strength using the parameters of this product, And use the same bevel gear forging mathematical model as the product, Calculate gear strength through dynamic software LS-Dyna, Comparing the gear strength with the actual tooth profile and the gear strength of the actual tooth profile, The gear strength obtained by LS-Dyna can be approximated by the theoretical calculation gear strength, In this way, you can quickly know at the beginning of the design whether the designed gear strength can withstand the load.

Growing evidence has indicated that opioids enhance replication of human immunodeficiency virus and hepatitis C virus in target cells. However, it is unknown whether opioids can enhance replication of other clinically important viral pathogens. In this study, the interaction of opioid agonists and human influenza A/WSN/33 (H1N1) virus was examined in human lung epithelial A549 cells. Cells were exposed to morphine, methadone or buprenorphine followed by human H1N1 viral infection. Exposure to methadone differentially enhanced viral propagation, consistent with an increase in virus adsorption, susceptibility to virus infection and viral protein synthesis. In contrast, morphine or buprenorphine did not alter H1N1 replication. Because A549 cells do not express opioid receptors, methadone-enhanced H1N1 replication in human lung cells may not be mediated through these receptors. The interaction of methadone and H1N1 virus was also examined in adult mice. Treatment with methadone significantly increased H1N1 viral replication in lungs. Our data suggest that use of methadone facilitates influenza A viral infection in lungs and might raise concerns regarding the possible consequence of an increased risk of serious influenza A virus infection in people who receive treatment in methadone maintenance programs.

Methamphetamine (Meth) is one of the most frequently abused drugs worldwide. Recent studies have indicated that antibodies with high affinity for Meth reduce its pharmacological effects. The purpose of this study was to develop a technique for virus-based passive immunization against Meth effects. We generated a recombinant adeno-associated virus serotype-8 vector (AAV-MethAb) carrying the gene for a Meth-specific monoclonal antibody (MethAb). Infection of 293 cells with AAV-MethAb resulted in the expression and secretion of antibodies which bind to Meth. The viral vector was then examined in adult ICR mice. Systemic administration of AAV-MethAb resulted in long-term expression of MethAb in the serum for up to 29 weeks. Serum collected from the animals receiving AAV-MethAb retained a high specificity for (+)-Meth. Animals were challenged with Meth five weeks after viral injection. Meth levels in the brain and serum were reduced while Meth-induced locomotor activity was significantly attenuated. In conclusion, AAV-MethAb administration effectively depletes Meth from brain and serum while reducing the behavioral response to Meth, and thus is a potential therapeutic approach for Meth abuse.

Parvovirus 4 (PARV4) is one of the emerging human parvoviruses discovered recently. PARV4 has long-lasting persistence in tissues after primary infection, but persistent PARV4 viremia has yet to be effectively detected in humans. In the present work, longitudinal serum samples from eleven patients with antiphospholipid syndrome were tested by nested polymerase chain reaction for the presence of PARV4 DNA. In one patient, PARV4 4 DNA was detected in all longitudinal serum samples collected over a period of 119 months. In addition, PARV4 DNA was present in two or more longitudinal serum samples from seven other patients. Two possible explanations are a persistent infection with intermittent low viral load below detection limit and a recurrent reactivation of latent infection. In conclusion, to our knowledge, this is the first direct evidence of detection of persistent PARV4 infection. Placental transmission may be one of the major routes of PARV4 infection in endemic areas if women of child-bearing age have continuous or intermittent circulating PARV4 DNA seen in our patients.

Following the constant improvements in technology and rapid developments in the computers, communications, and consumer electronics (3C) industry, mobile devices have become assistive tools for everyday life. They are lightweight, thin, and convenient for carry and their functionality is akin to a portable computer. However, these devices are normally equipped with small displays. At times when a larger screen is needed, such as when sharing information, watching videos, or discussing in groups of people, the physical device must be passed between all members in the group. Therefore, this study proposes a convenient way to integrate the resources, including display, computation, communication, etc., of multiple mobile devices to create a portable cloud for various applications. This study focused on display integration, combining multiple device screens into one large screen for data display, interaction, and sharing in meetings, for entertainment, or at school. The screens of mobile devices in different locations can also be integrated to create a dynamic billboard. This study also incorporated near field communication (NFC) to share data from one device with all other integrated devices. Wi-Fi Direct was used for group device communication to eliminate the need of Internet connection.