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2. Pharmacological treatment of asthma in a cohort of adults during a 20-year period: results from the European Community Respiratory Health Survey I, II and III

Author

Christer Janson, Simone Accordini, Lucia Cazzoletti, Isa Cerveri, Sebastien Chanoine, Angelo Corsico, Diogenes Seraphim Ferreira, Judith Garcia-Aymerich, David Gislason, Rune Nielsen, Ane Johannessen, Rain Jogi, Andrei Malinovschi, Jesús Martinez-Moratalla Rovira, Alessandro Marcon, Isabelle Pin, Jennifer Quint, Valerie Siroux, Enrique Almar, Valeria Bellisario, Karl A. Franklin, José A. Gullón, Mathias Holm, Joachim Heinrich, Dennis Nowak, José Luis Sánchez-Ramos, Joost J. Weyler, Deborah Jarvis, The members of the ECRHS I scientific team., P. Burney, S. Chinn, C. Luczynska, D. Jarvis, E. Lai, P. Vermeire, H. Kesteloot, J. Bousquet, D. Nowak, J. Prichard, R. de Marco, B. Rijcken, J.M. Anto, J. Sunyer, J. Alves, G. Boman, N. Nielsen, P. Paoletti, M. Abramson, J. Kutin, F. van Bastelaer, R. Jõgi, A. Taytard, I. Pin, C. Pison, F. Neukirch, R. Liard, J. Knani, H-E. Wichmann, J. Heinrich, H. Magnussen, T. Gislason, D. Gislason, A. Marinoni, I. Cerveri, M. Bugiani, C. Bucca, C. Romano, L. Cascio, C. Campello, J. Droste, M. Kerkhof, A. Gulsvik, E. Omenaas, J. Martinez-Moratalla, E. Almar, A. Mateos, M. Arévalo, A. Sánchez, M. Vizcaya, X. Aguilar, A. Teixidó, J.M. Antó, M. Kogevinas, F. Burgos, J. Castellsagué, J. Roca, JB. Soriano, A. Tobías, N. Muiñozguren, J. Ramos González, A. Capelastegui, J. Maldonado Pérez, A. Pereira, J. Sánchez, J. Quiros, I. Huerta, F. Payo, N. Lindholm, P. Plaschke, C. Janson, E. Björnsson, L. Rosenhall, E. Norrman, B. Lundbäck, U. Ackermann-Liebrich, N. Küenzli, A. Perruchoud, M. Burr, J. Layzell, R. Hall, B. Harrison, The members of the ECRHS II scientific team., J. Knox, M. Wjst, N. Kuenzli, E.H. Walters, J. Raven, J. Weyler, M. van Sprundel, V. Nelen, A. Soon, C. Raherison, J. Ferran-Quentin, B. Leynaert, M. Zureik, P.J. Bousquet, C. Frye, I. Meyer, E. Bjornsson, K.B. Jörundsdóttir, S. Villani, M. Ponzio, F. Frigerio, M. Comelli, M. Grassi, A. Corsico, R. Bono, P. Piccioni, E. Caria, A. Carosso, E. Migliore, G. Castiglioni, G. Verlato, E. Zanolin, S. Accordini, A. Poli, V. Lo Cascio, M. Ferrari, I. Cazzoletti, C. Svanes, B. Laerum, J. Martinez-Moratalla Rovira, C. Boix, G. González, J.M. Ignacio García, J. Solera, J. Damián, J.P. Zock, X. Basagaña, A. Jaen, C. Acosta, N. Muñozguren, J. Ramos, I. Urrutia, U. Aguirre, J. Maldonado, J.L. Sanchez, A. de la Vega, L. Palenciano, J. Azofra, A. Cañada, K. Toren, L. Lillienberg, A.C. Olin, B. Balder, A. Pfeifer-Nilsson, R. Sundberg, D. Norback, G. Wieslander, M. Gunnbjornsdottir, M. Soderberg, K.A. Franklin, B. Lundback, B. Forsberg, L. Nystrom, B. Dibbert, M. Hazenkamp, M. Brutsche, D. Seaton, The members of the ECRHS III scientific team., M. Tumilty, J. Potts, T. Gislasson, T. Rochat, B. Leyneart, G. Benke, S. Dharmage, B. Thompson, S. Kaushik, M. Matheson, H. Bentouhami, H. Orru, P.O. Girodet, V. Siroux, J. Ferran, J.L. Cracowski, P. Demoly, A. Bourdin, I. Vachier, D. Soussan, D. Courbon, C. Neukirch, L. Alavoine, X. Duval, I. Poirier, E. Becker, G. Woelke, O. Manuwald, A-M. Kirsten, B. Benediktsdottir, E.S. Arnardottir, M. Clausen, G. Gudmundsson, L. Gudmundsdottir, H. Palsdottir, K. Olafsdottir, S. Sigmundsdottir, K. Bara-Jörundsdottir, A. Grosso, F. Albicini, E. Gini, E.M. Di Vincenzo, V. Ronzoni, F. Campanella, M. Gnesi, F. Manzoni, L. Rossi, O. Ferraro, R. Tassinari, V. Bellisario, G. Trucco, L. Calciano, L. Cazzoletti, A.M. Fratta Pasini, F. Locatelli, P. Marchetti, A. Marcon, E. Montoli, G. Nguyen, M. Olivieri, C. Papadopoulou, C. Posenato, G. Pesce, P. Vallerio, H.M. Boezen, A. Johannessen, T. Skorge, F. Gomez Real, S. García, A. Núñez, P. López, R. Sánchez, E. Mancebo, J-M. Antó, J. Garcia-Aymerich, A.E. Carsin, C. Sanjuas, S. Guerra, B. Jacquemin, P. Davdand Galdakao, S. Pascual, J. Antonio Maldonado, J.L. Sánchez, L. Palacios, N. Sánchez, M. Fernández, B. Robles, K. Torén, M. Holm, J-L. Kim, A-C. Olin, A. Dahlman-Höglund, L. Braback, L. Modig, B. Järvholm, K.A. Bertilsson, H. Franklin, C. Wahlgreen, B. Andersson, U. Spetz Nystrom, G.M. Bodinaa Lund, K. Nisser, N.M. Probst-Hensch, N. Künzli, D. Stolz, C. Schindler, J.M. Gaspoz, E. Zemp Stutz, M. Adam, C. Autenrieth, I. Curjuric, J. Dratva, A. Di Pasquale, R. Ducret-Stich, E. Fischer, L. Grize, A. Hensel, D. Keidel, A. Kumar, M. Imboden, N. Maire, A. Mehta, H. Phuleria, M. Ragettli, M. Ritter, E. Schaffner, G.A. Thun, A. Ineichen, T. Schikowski, M. Tarantino, M. Tsai, S. Kapur, R. Newson, N. Innes, and A. Wilson

Subjects
Medicine
Abstract

Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has undergone large changes. We studied changes in the treatment of asthma over a 20-year period and identified factors associated with the regular use of inhaled corticosteroid (ICS) treatment. Changes in the use of medication were determined in 4617 randomly selected subjects, while changes in adults with persistent asthma were analysed in 369 participants. The study compares data from three surveys in 24 centres in 11 countries. The use of ICSs increased from 1.7% to 5.9% in the general population and the regular use of ICSs increased from 19% to 34% among persistent asthmatic subjects. The proportion of asthmatic subjects reporting asthma attacks in the last 12 months decreased, while the proportion that had seen a doctor in the last 12 months remained unchanged (42%). Subjects with asthma who had experienced attacks or had seen a doctor were more likely to use ICSs on a regular basis. Although ICS use has increased, only one-third of subjects with persistent asthma take ICSs on a regular basis. Less than half had seen a doctor during the last year. This indicates that underuse of ICSs and lack of regular healthcare contacts remains a problem in the management of asthma.

Published
2019
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14. Removal of direct navy blue dye from aqueous solutions using banana peels

Author

F. Fuentes Gandara, I. Piñeres Ariza, A. Zambrano Arevalo, G. Castellar Ortega, C. Herrera Herrera, S. Castro Muñoz, G. Peluffo Foliaco, and J. Pinedo-Hernández

Subjects
adsorption, banana peel, biochar, isotherms, navy blue dye, textile industry, Environmental sciences, GE1-350
Abstract

BACKGROUND AND OBJECTIVES: The textile industry is known to produce large amounts of dyes and other harmful contaminants. This issue is of great importance as it adversely affects both water resources and the well-being of organisms. To address this issue, biochar is frequently used as a sustainable and environmentally friendly material for removing chemical contaminants during wastewater treatment. The aim of this study was to evaluate the viability of utilizing biochar obtained from banana peels as a promising bioadsorbent for reducing environmental pollution caused by direct navy blue dye. The research investigated various factors such as temperature, potential of hydrogen levels, particle size, and concentrations to determine the effectiveness of biochar in dye removal.METHODS: The biochar obtained was separated into powdered and granular forms based on particle sizes of 425 and 850 micrometer, respectively. The biochar's textural characteristics were assessed through nitrogen adsorption/desorption isotherms. Fourier transform infrared spectroscopy and the Boehm method were employed to analyze and measure organic functional groups, specifically acidic groups, for identification and quantification purposes. Batch experiments were performed to ascertain the effects of the initial concentration and potential of hydrogen on the adsorption capacity and removal percentage.FINDINGS: The results indicated that the powdered biochar obtained at 500 degrees Celsius had the higher surface area, with a value of 80.4 square meter per gram. The biochar demonstrated remarkable removal percentages, achieving 97 percent at the lowest concentration and 89 percent at the highest concentration, when the potential of hydrogen was adjusted to a value of 6. The Freundlich model gave the best fit to the experimental data for this biochar and obeyed pseudo second order kinetics, with correlation coefficients of 0.93 and 0.99, respectively. CONCLUSION: This study provides evidence of the high removal efficiency achieved by biochar derived from banana peel waste in the removal of direct navy blue dye. Precise temperature control during the calcination process is essential to ensure its favorable chemical and textural properties. The unique attributes of banana peel biochar position it as an exceptionally promising adsorbent material. Not only is it cost-effective and environmentally friendly, but it also outperforms current wastewater treatment technologies in terms of competitiveness. Its remarkable ability to reduce contaminants, particularly the removal of dyes, further solidifies its potential as a highly effective solution.

Published
2024
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15. Évaluation multicentrique et randomisée de l’impact des conseillers en environnement intérieur sur le contrôle de l’asthme : l’étude ECENVIR

Author

J.P. Gangneux, H. Morel, F.X. Blanc, P. Bonniaud, G. Boza, A. Briault, J. Brouard, D. Charpin, C. Chenivesse, H. Colas, A. Cottereau, G. Dalampira, F. De Blay, X. Debeillex, P. Dumont, K. Elchehaded, M. Fayon, S. Fry, E. Hullo, A. Leblanc, J. Letreut, A. Magnan, G. Mahay, J.M. Perotin-Collard, H. Pegliasco, I. Pin, C. Pison, N. Rossignoli, V. Siao Him Fa, H. Ziani Bey, L. Com-Ruelle, J. Morcet, E. Oger, P. Le Cann, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Laboratoire d'étude et de recherche en environnement et santé (LERES), Département des sciences en santé environnementale (DEESSE), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Département Santé Environnement Travail et Génie Sanitaire (DSETGS)

Subjects
Visite, Immunology and Allergy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Asthme, Etude ECENVIR, Conseillers en environnement intérieur (CEI)
Abstract

International audience; Introduction (contexte de la recherche) :L’exposition répétée des patients asthmatiques aux allergènes intradomiciliaires contribue aux exacerbations de l’asthme. Plusieurs stratégies d’intervention sont proposées, parmi lesquelles, la visite domiciliaire de conseillers en environnement intérieur (CEI). Les CEI établissent un état des lieu au domicile du patient et proposent des mesures de remédiation afin d’améliorer les fonctions respiratoires. Plusieurs études monocentriques ont montré l’intérêt d’une telle démarche.ObjectifL’étude ECENVIR est un essai clinique, multicentrique, prospectif et randomisé qui vise à évaluer l’impact des CEI sur le niveau de contrôle de l’asthme.Méthodes :Au total, 104 patients ont été inclus dont 85 patients ont été suivis médicalement et randomisés dans 2 groupes : le Groupe Intervention (GI) a bénéficié d’une visite de CEI avec prélèvements pour mesures d’allergènes et conseils à l’inclusion et après 12 mois de suivi ; et le groupe témoin (GT) a bénéficié d’une même visite de contrôle uniquement à M12.Résultats :Le critère de jugement principal a été analysé chez 71/85 patients : 34 dans le GI et 37 dans le GT. A M12, une amélioration du contrôle de l’asthme était notée dans le GI avec une diminution du nombre d’asthme sévère et une augmentation d’asthme intermittent (p = 0,05) comparativement au GT (p = 0,24). En comparaison intergroupe, 50 % (17/34) des patients du GI ont montré une amélioration clinique comparativement au GT (p = 0,43). Bien que non statistiquement significative probablement dû à un manque de puissance, les patients du GI avaient 1,5 fois plus de chance de s’améliorer cliniquement en analyse multivariée (OR 1,47 CI95 % [0,57–3,75]. Les analyses secondaires montrent que : (i) dans la population des asthmes sévères, 12/16 patients (75 %) du GI se sont améliorés contre 7/16 du GT(44 %)(p = 0,06) ; (ii) la consommation des corticoïdes oraux et le taux d’hospitalisation sont significativement diminués dans le groupe ayant bénéficié de conseils (p = 0,029 et p = 0,042, respectivement).Conclusions :L’intervention des CEI est bénéfique cliniquement sur le niveau du contrôle de l’asthme et permet sur le plan économique une diminution de la consommation de soins, en cours d’investigation via les données d’Assurance maladie.

Published
2022
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18. Cobertura LiDAR-Fotogramétrica, batimetría y levantamiento de infraestructuras como soporte al análisis de riesgos de inundación en la subcuenca del río Genil

Author

J. J. Vales-Bravo, E. M. Méndez-Caballero, R. Prieto-Molina, L. Granado-Ruíz, I. Pino-Serrato, E. Sañudo-Costoya, G. García-Alén Lores, A. M. Pello-Rodríguez, A. Zabala-Ordóñez, and E. Ortega-Díaz

Subjects
lidar, fotogrametría, gnss, batimetría, modelización hidráulica, dron, Geography (General), G1-922
Abstract

Las inundaciones son los desastres naturales que afectan a más personas en el Área Atlántica. En este sentido, el proyecto AA-Floods tiene el objetivo de desarrollar y poner en valor nuevas herramientas, planes y regulaciones que mejoren la gestión y la respuesta a las inundaciones. La importancia de la información altimétrica de calidad para la evaluación del peligro de inundación se basa en el conocimiento lo más detallado y preciso posible del relieve y de las alturas de los elementos situados sobre el suelo. Para ello se ha llevado a cabo una cobertura LiDAR de densidad 21 ptos/m² y fotogramétrica de resolución 0,10 m para la generación de productos altimétricos de gran exactitud posicional y alta precisión en los ámbitos de estudio de la cuenca del río Genil. Así mismo, se ha realizado el levantamiento batimétrico del cauce del río Genil y la obtención de Modelo final Topobatimétrico. Además, para el desarrollo adecuado de la modelización hidráulica y determinación de zonas inundables es necesario tomar en consideración todos aquellos elementos estructurales del cauce que afectan a la inundabilidad. Se ha realizado análisis de zonas inundables con estas fuentes de información que mejoran las utilizadas por el SNCZI. Los resultados se han contrastado con las láminas de inundación de 2010 cartografiadas mediante observación directa mediante satélite Radar.

Published
2024
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19. Generational diversity, overconfidence and decision-making in family business: A knowledge heterogeneity perspective

Author

Fu-Sheng Tsai, Aida Nugroho, I-Pin Lu, Che-Hung Lin, and Julia L. Lin

Subjects
Strategy and Management, 05 social sciences, Perspective (graphical), Collective intelligence, 050109 social psychology, Context (language use), Argument, 0502 economics and business, Kinship, 0501 psychology and cognitive sciences, Business and International Management, Psychology, Social psychology, 050203 business & management, Mechanism (sociology), Overconfidence effect, Diversity (business)
Abstract

Is generational diversity really “bad” for collective decision-making effectiveness in the family business? We argue that generational diversity reflects collective knowledge heterogeneity, and that through overconfidence as an important collective psychological mechanism, generational diversity may counter-intuitively benefit organizational consequences. Data from sixty decision-making teams in Indonesian family businesses with Chinese kinship relations suggested: first, generational diversity has positive effect on decision-making; second, generational diversity influences on group overconfidence negatively; third, overconfidence influences decision-making negatively; and fourth, overconfidence mediates in the relationship between diversity and decision effectiveness. All theoretical argument and empirical discussions grounded on knowledge heterogeneity perspective generated implications for theory and practices of decision-making in family businesses context.

Published
2018
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21. Blockchain-Based Healthcare Information Preservation Using Extended Chaotic Maps for HIPAA Privacy/Security Regulations

Author

Ting-Shun Kung, Tian-Fu Lee, and I-Pin Chang

Subjects
blockchain, Technology, QH301-705.5, information security, Computer science, QC1-999, Data security, Access control, Computer security, computer.software_genre, Login, chaotic maps, Secure communication, Server, Information system, General Materials Science, Biology (General), QD1-999, healthcare information, Instrumentation, Wearable technology, Fluid Flow and Transfer Processes, HIPAA, patient privacy, business.industry, Physics, Process Chemistry and Technology, access control, General Engineering, Information security, Engineering (General). Civil engineering (General), Computer Science Applications, Chemistry, TA1-2040, business, computer
Abstract

A healthcare information system allows patients and other users to remotely login to medical services to access health data through the Internet. To protect the privacy of patients and security over the public network, secure communication is required. Therefore, the security of data in transmission has been attracting increasing attention. In recent years, blockchain technology has also attracted more attention. Relevant research has been published at a high rate. Most methods of satisfying relevant security-related regulations use modular and exponential calculation. This study proposes a medical care information preservation mechanism that considers the entire process of data storage in devices from wearable devices to mobile devices to medical center servers. The entire process is protected and complies with HIPAA privacy and security regulations. The proposed scheme uses extended chaotic map technology to develop ID-based key negotiation for wearable devices, and thereby reduces the amount of computing that must be carried out by wearable devices and achieve lightness quantify. It also uses the non-tamperability of the blockchain to ensure that the data have not been tampered with, improving data security. The proposed mechanism can resist a variety of attacks and is computationally lighter than the elliptic curve point multiplication that has been used elsewhere, while retaining its security characteristics.

Published
2021
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23. Diagnostic du syndrome d’apnée obstructive du sommeil chez l’enfant (2–18 ans) : place de la polysomnographie et de la polygraphie ventilatoire

Author

J. Briffod, M.-J. Challamel, H. Bourdin, Patricia Franco, F. Braun, and I. Pin

Subjects
medicine.medical_specialty, Cognitive Neuroscience, MEDLINE, Scoring criteria, Polysomnography, Respiratory polygraphy, Sleep medicine, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, 030225 pediatrics, medicine, Pulmonologists, medicine.diagnostic_test, business.industry, Sleep apnea, medicine.disease, respiratory tract diseases, Obstructive sleep apnea, Neuropsychology and Physiological Psychology, Neurology, Pediatrics, Perinatology and Child Health, Emergency medicine, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Resume Sous l’egide de la Societe francaise de recherche et de medecine du sommeil (SFRMS), une journee de travail a ete consacree au syndrome d’apnees obstructives du sommeil (SAOS) de l’enfant. Un groupe multidisciplinaire de praticiens specialistes de cette pathologie (pneumologues, pediatres, otorhinolaryngologues, neurophysiologistes, specialistes du sommeil) a fait le point a travers leurs experiences et les donnees de la litterature sur la place des enregistrements electro-physiologiques dans le diagnostic du SAOS. Les criteres diagnostiques recommandes par l’American Academy of Sleep Medicine (AASM), revises en 2012 et en 2014, sont exposes : methodologie des enregistrements de sommeil, definitions des evenements respiratoires et regles de codage visuel. Les criteres diagnostiques des troubles respiratoires du sommeil chez l’enfant sur les enregistrements polysomnographiques (PSG) et les recommandations de la Haute Autorite de sante sur les indications de la polysomnographie sont egalement rapportes. L’interet et les limites de la PSG en unite de sommeil, de la PSG ambulatoire et de la polygraphie ventilatoire (PV) sont decrits. Un arbre decisionnel a ete elabore dans le but de repondre au mieux au besoin diagnostique et de suivi de ces enfants.

Published
2017
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24. Tentative de suicide par anaphylaxie alimentaire volontaire

Author

A. Bocquet, C. Chatain, C. Boutelleau, I. Pin, P. Pralong, and Marie-Thérèse Leccia

Subjects
Immunology and Allergy
Abstract

Introduction Il existe un lien entre allergie alimentaire et desordres emotionnels et comportementaux, en particulier alexithymie (difficulte a identifier, differencier et exprimer ses emotions avec un mode de pensee guide par des regles strictes), depression, anxiete et troubles du deficit de l’attention avec hyperactivite, surtout parmi les adolescents. Nous decrivons 2 cas de tentative de suicide (TS) par anaphylaxie alimentaire chez des adolescents vivants en famille d’accueil. Methodes Cas 1 : Une fille de 11 ans atteinte de troubles du comportement avec crises clastiques et idees suicidaires traites par Risperidone et Cyamemazine, d’eczema, d’asthme et de polyallergie alimentaire au lait, œuf, arachide, fruits a coque et moutarde a presente une anaphylaxie de grade 2 avec malaise, urticaire et vomissements apres ingestion volontaire de bonbons M&M's a l’arachide. Cas 2 : Un garcon de 17 ans atteint de troubles de comportement avec TS par arme blanche, traite par Risperidone, d’eczema, d’asthme et de polyallergie alimentaire a l’arachide, noisette et noix a fait une anaphylaxie de grade 2 avec dyspnee, œdeme pharynge et urticaire apres consommation volontaire et importante de cacahuetes et de gâteaux chocolates a la noisette. Resultats Les 2 enfants presentent une sensibilisation importante aux allergenes de stockage des fruits a coque et arachide. Discussion L’anaphylaxie alimentaire peut representer un traumatisme psychologique responsable d’anxiete chez le patient et ses proches. Une anxiete excessive peut conduire a des evictions alimentaires demesurees et limitations sociales, responsables d’une diminution de la qualite de vie et parfois de symptomes depressifs avec idees suicidaires. Un traumatisme affectif a contribue aux troubles de comportement chez ces 2 enfants. Dans la litterature, seulement deux cas de TS et un cas de suicide acheve par anaphylaxie alimentaire volontaire ont ete decrits. La TS par anaphylaxie volontaire serait probablement sous-estimee, car non avouee par les patients ou non reconnue par les soignants. Conclusion Il est important de connaitre ce moyen de TS, de rechercher un desordre emotionnel et de proposer un soutien psychologique a tout patient allergique alimentaire.

Published
2020
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25. Light-Weighted Password-Based Multi-Group Authenticated Key Agreement for Wireless Sensor Networks

Author

Mao-Sung Chen, Tung-Kuan Liu, and I-Pin Chang

Subjects
020205 medical informatics, Computer science, 02 engineering and technology, 01 natural sciences, lcsh:Technology, chaotic maps, lcsh:Chemistry, sensor networks, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Session key, Overhead (computing), General Materials Science, 010301 acoustics, Instrumentation, lcsh:QH301-705.5, Secure channel, Group key, Fluid Flow and Transfer Processes, Password, group authentication, business.industry, lcsh:T, Process Chemistry and Technology, General Engineering, Public key infrastructure, Modular design, lcsh:QC1-999, Computer Science Applications, lcsh:Biology (General), lcsh:QD1-999, lcsh:TA1-2040, extended chaotic maps, business, lcsh:Engineering (General). Civil engineering (General), Wireless sensor network, lcsh:Physics, Computer network
Abstract

Security is a critical issue for medical and health care systems. Password-based group-authenticated key agreement for wireless sensor networks (WSNs) allows a group of sensor nodes to negotiate a common session key by using password authentication and to establish a secure channel by this session key. Many group key agreement protocols use the public key infrastructure, modular exponential computations on an elliptic curve to provide high security, and thus increase sensor nodes&rsquo, overhead and require extra equipment for storing long-term secret keys. This work develops a novel group key agreement protocol using password authentication for WSNs, which is based on extended chaotic maps and does not require time-consuming modular exponential computations or scalar multiplications on an elliptic curve. Additionally, the proposed protocol is suitable for multiple independent groups and ensures that the real identities of group members cannot be revealed. The proposed protocol is not only more secure than related group key agreement protocols but also more efficient.

Published
2019

26. Fixed-bed adsorption of copper from aqueous media using chitosan-coated bentonite, chitosan-coated sand, and chitosan-coated kaolinite

Author

Cybelle Morales Futalan, Piaw Phatai, Jung-Hung Yang, Meng-Wei Wan, and I-Pin Chen

Subjects
Thermogravimetric analysis, Health, Toxicology and Mutagenesis, chemistry.chemical_element, 010501 environmental sciences, 01 natural sciences, Chitosan, chemistry.chemical_compound, Adsorption, Sand, Spectroscopy, Fourier Transform Infrared, Environmental Chemistry, Kaolinite, Fourier transform infrared spectroscopy, Kaolin, 0105 earth and related environmental sciences, Aqueous solution, Chemistry, General Medicine, Hydrogen-Ion Concentration, Pollution, Copper, Bentonite, Water Pollutants, Chemical, Nuclear chemistry
Abstract

Fixed-bed studies were performed to evaluate the removal efficiency of copper (Cu(II)) from aqueous solution using chitosan-coated bentonite (CCB), chitosan-coated sand (CCS), and chitosan-coated kaolinite (CCK). The thermal and morphological properties of CCB, CCK, and CCS were characterized using thermogravimetric analysis, Fourier transform infrared spectroscopy, and the Brunauer-Emmett-Teller method. Dynamic experiments were carried out to investigate the effect of solution pH (3.0 to 5.0) and initial Cu(II) concentration (200 to 1000 mg/L) on the time to reach breakthrough (tb), total volume of treated effluent (Veff), and adsorption capacity at breakthrough (qb). Results show that increasing the initial Cu(II) concentration inhibits the column performance where lower Veff, tb, and qb were obtained. Decreasing the pH from 5.0 to 3.0 led to improved removal efficiency with higher values of Veff, tb, and qb. Under pH 3.0 and 200 mg/L, the maximum removal efficiency of 68.60%, 56.10%, and 58.90% for Cu(II) was attained using CCB, CCS, and CCK, respectively. The Thomas model was determined to adequately predict the breakthrough curves based on high values of coefficient of determination (R2 ≥ 0.8503). Regeneration studies were carried out using 0.1 M HCl and 0.1 M NaOH solution in the saturated column of CCB, CCK, and CCS.

Published
2019

27. La presencia de infiltración linfovascular y de un alto número de mitosis se asocia a un mayor riesgo de recidiva en sarcoma pleomórfico dérmico

Author

M. Pons Benavent, E. Ríos-Viñuela, E. Nagore, C. Monteagudo, M. Aguerralde, D. Mata Cano, B. Llombart, C. Serra-Guillén, I. Pinazo Canales, C. Requena, and O. Sanmartín

Subjects
Pleomorphic dermal sarcoma, Atypical fibroxanthoma, Lymphovascular invasion, Pleomorphic sarcoma, Mitosis, Dermatology, RL1-803, Internal medicine, RC31-1245
Abstract

Resumen: Introducción y objetivo: El fibroxantoma atípico (FXA) y el sarcoma pleomórfico dérmico (SPD) son neoplasias de origen mesenquimal poco frecuentes. Debido a la baja incidencia del SPD y a una nomenclatura históricamente confusa existe poca información acerca de la verdadera agresividad de este tumor. Realizamos el presente estudio con el objetivo de identificar qué características clínicas y/o histológicas del SPD son predictoras de riesgo de recidiva. Material y método: Se diseñó un estudio bicéntrico observacional retrospectivo de 31 casos de SPD diagnosticados y tratados en el Hospital Clínico Universitario de Valencia y el Instituto Valenciano de Oncología, entre los años 2005 y 2020. Se realizó un análisis descriptivo de las características clínicas e histológicas, un análisis inferencial univariado y un análisis multivariado mediante la regresión de Cox. Resultados: En el análisis univariado, la recidiva tumoral (p

Published
2023
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28. Removal of algae via coagulation with magnetic MnFe2O4 recycled from drinking-water treatment sludge

Author

Kuo-Jung Hsien, S. S. Lin, C. W. Yeh, Chi-Chuan Kan, and I-Pin Chen

Subjects
Algae, biology, chemistry, Oxidizing agent, Coagulation (water treatment), Sewage sludge treatment, chemistry.chemical_element, Water treatment, Manganese, Treatment costs, biology.organism_classification, Pulp and paper industry, Mimo communication
Abstract

In water treatment plants, oxidizing agents (e.g., NaOCl) are commonly added prior to coagulation. This reduces algae activity and enhances coagulation effectiveness. However, oxidants generate harmful by-products (e.g., trihalomethanes, THMs). Landfill sites are scarce and sludge treatment processes are costly. Therefore, effective utilization of wasted sludge will lower removal and treatment costs significantly. magnetic iron and manganese oxides (MIMO) recovered from water treatment plant sludge (WTP sludge) were utilized for algae removal. This reduces sludge handling costs and waste materials are effectively recycled and reused.

Published
2018
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29. Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology

Author

Karin C. Lødrup Carlsen, L. Cecchi, F. Portejoie, T. Vontetsianos, Olivier Vandenplas, M. van Hague, D. Mora Bogado, M. Illario, Dana Wallace, L. Namazova-Baranova, E. Asayag, I. Ribeirinho, E. Costa, Shona Pedersen, Inger Kull, Davor Plavec, M. Morais-Almeida, Mickael Bewick, N.H. Chavannes, I. J. Ansotegui, G. De Carlo, K. S. Bennoor, Faradiba Sarquis Serpa, S. Arnavielle, F. Corti, Moises A. Calderon, Martín Bedolla-Barajas, Mette Sørensen, Isabella Annesi-Maesano, Elaine Colgan, Przemyslaw Kardas, M. van Eerd, Jorge Maspero, Valérie Siroux, Isabelle Momas, Ralph Mösges, Yves Dauvilliers, T. Keil, T. Bieber, Marit Westman, Rachel Nadif, O. Pfaar, A.C. Carvalho Coehlo, R. M. Cortés-Grimaldo, I. Skrindo, Piotr Kuna, Nicola Scichilone, Antonella Muraro, Kimihiro Okubo, Paulo Augusto Moreira Camargos, C. Cartier, Oliver Pfaar, K. Ohta, Barbara P. Yawn, Igor Kaidashev, Michel Thibaudon, X. Basagana, I. Kaidashev, Bilun Gemicioglu, S. Genova, Hae-Sim Park, J.J. Matta Campos, Simon Walker, Ulf Darsow, Fulvio Braido, J. Salimäki, T. Zuberbier, Raphaël Chiron, Mohammad Reza Masjedi, G.D. Marshall, Branislava Milenkovic, W. J. Fokkens, Eric D. Bateman, Robert M. Naclerio, Steve Montefort, M. de Fátima Emerson, T. Werfel, Cemal Cingi, A. Szylling, Martin Wagenmann, I. Baiardini, L. T. T. Le, N. Khaltaev, Ki-Suck Jung, Agnieszka Lipiec, Panayiotis K. Yiallouros, A Valero, R. Gerth van Wijk, L. Hernández, Marek L. Kowalski, C. Zubrinich, Sinthia Bosnic-Anticevich, Miguel A. Sierra, Erik Melén, T. Haahtela, Rute Almeida, Violeta Kvedariene, R. Pawankar, T.A. Popov, Flore Amat, Sanna Toppila-Salmi, M. Gotua, A. Sheikh, A. Bedbrook, Torsten Zuberbier, B. De Martino, Gérard Dray, Francesca Avolio, E. Mandajieva, B. Samolinski, Petr Panzner, P. Kuna, Philippe-Jean Bousquet, T. D. Nyembue, Luo Zhang, Leyla Namazova-Baranova, Ana Maria Carriazo, João Fonseca, E. Van Ganse, Roland Buhl, M. Bochenska Marciniak, Cristiana Stellato, J. da Silva, J. E. Gereda, Han-Jung Park, M.C. Costa-Dominguez, W. Carr, Dirceu Solé, S. Forti, Nanshan Zhong, Jordi Sunyer, Alain Didier, Y. Z. Chen, Thomas B. Casale, Jim Phillips, Isabelle Bosse, Manuel Teixeira Veríssimo, D. Y. Wang, U. Trama, Cristina Bárbara, David Somekh, T. Camuzat, R. N. Naclerio, Enrico Novellino, Leszek Klimek, M. Rodriguez Gonzalez, Holger J. Schünemann, Mario Barbagallo, D. Larenas-Linnemann, Mario Sánchez-Borges, Massimo Triggiani, Y. Okamoto, E. Mathieu-Dupas, N. Di Carluccio, S. Toppila-Salmi, Omer Kalayci, Rudolf Valenta, J. Coll, F. de Blay, Wienczyslawa Czarlewski, W. Pohl, Piotr Wroczyński, Kian Fan Chung, Nikolaos G. Papadopoulos, Pascal Demoly, Hubert Blain, M. Crescenzo, O. Kalayci, Leocadio Rodríguez-Mañas, G. Moda, L. Cox, Z. Gutter, A. Mair, Andrew Bush, Maria-Dolores Mogica-Martinez, Giorgio Walter Canonica, Antonio Valero, Daniel Laune, A. Zurkuhlen, Paul C. Potter, D. Wallace, Gabrielle L. Onorato, Mihaela Zidarn, E.P. Prokopakis, Anne Lise Courbis, Sergio Bonini, Ruta Dubakiene, A. Papi, Y. El-Gamal, Jacques Mercier, Wytske Fokkens, Rodolphe Bourret, S. Palkonen, A. Yorgancioglu, G. Vezzani, J. A. Rizzo, D. Plavec, D. Caillot, G. De Feo, E. Menditto, Caterina Bucca, A. C. Pozzi, Hironori Sagara, I. Grisle, I. Pin, Christopher E. Brightling, Ludger Klimek, F.F. Morato-Castro, Désirée Larenas-Linnemann, Alessandro Vatrella, A. A. Cruz, Guy Joos, E.D. Bateman, Erendira Rodriguez-Zagal, H. Douagui, T. To, Edgardo Jares, C. Bindslev-Jensen, G. Levato, J. O. B. Hourihane, R. Rajabian-Soderlund, C. Odzhakova, J. Bousquet, M. T. Ventura, Arzu Yorgancioglu, Osman M. Yusuf, H. J. Zar, Giovanni Rolla, Sebastian L. Johnston, M.S. Dykewicz, Esben Eller, A. Gamkrelidze, Filip Raciborski, Renzo Angles, Rafael Stelmach, M. Nogues, David Price, Mário Morais-Almeida, Tari Haahtela, Teresa To, D. Conforti, Stephen R. Durham, S. Gonzalez Diaz, V. Cardona, Werner Aberer, B. Milenkovic, Luigi Napoli, K. C. Bergmann, P W Hellings, M. Lessa, P. Panzner, Alfonso M. Cepeda Sarabia, M. Guidacci, A.L. Matos, Todor A. Popov, C. Suppli Ulrik, Diana Deleanu, N. de Paula Motta Rubini, Carsten Bindslev-Jensen, I. Majer, Ioana Agache, B. A. Barreto, R. Picard, Erkka Valovirta, A. Fink-Wagner, L. Colas, João O. Malva, Thomas Keil, M. T. Burguete Cabañas, Bolesław Samoliński, M.H. Garcia-Cruz, L.P. Boulet, K. Nekam, Edyta Krzych-Fałta, P. Devillier, J. Ferreira de Mello, Jussi Karjalainen, I. Bogus-Buczynska, Susan Waserman, Marcus Maurer, Tomas Chivato, Elena Bacci, M. Przemecka, Olga Lourenço, José Miguel Fuentes-Pérez, M. Zidarn, Talant Sooronbaev, J.M. Anto, W. Czarlewski, R. Murray, Luís Nogueira-Silva, G. Passalacqua, E. Chkhartishvili, Oscar Mayora, Victoria Cardona, M. Sondermann, Piotr Lacwik, S. Ouedraogo, I. Baroni, Artur Z. Białoszewski, G Scadding, J. Strozek, R. Emuzyte, Neven Miculinic, Ruby Pawankar, Ken Ohta, I. Agache, J.L. Gálvez-Romero, Nikos G. Papadopoulos, E. O. Meltzer, I. Annesi-Maesano, E. De Manuel Keenoy, Jorge A. Luna-Pech, Ana Margarida Pereira, Paul Potter, M. Ortega Cisneros, J. Li, K. F. Rabe, M. Rottem, Mikael Benson, Ali Fuat Kalyoncu, Dermot Ryan, Dieter Maier, C.Y. García-Cobas, S. Bialek, G. Du Toit, S. Shamai, S. Mavale-Manuel, Rojin Rajabian-Soderlund, Maddalena Illario, Philippe Devillier, F. Rodenas, Emmanuel P. Prokopakis, De Yun Wang, Niels H. Chavannes, E.H.D. Bel, Bianca Beghe, Sietze Reitsma, John Wright, O. Lourenço, L.T.T. Le, Josep M. Antó, T. Casale, Paul K. Keith, K. C. Lødrup Carlsen, P. Demoly, Mikael Kuitunen, Marc Humbert, A. M. Cepeda Sarabia, Ignacio J. Ansotegui, M.C. Rizzo, Davide Caimmi, Milan Sova, Nick A. Guldemond, P. Yakovliev, Judah A. Denburg, Jaime Correia de Sousa, Elisabete Melo-Gomes, Aziz Sheikh, I. Bosse, M. M. Ciaravolo, S. Di Capua Ercolano, Alpana Mair, P. Lieberman, Isabella Pali-Schöll, Leif Bjermer, G. De Vries, M. Roman Rodriguez, Johanna Salimäki, Carmen Panaitescu, F. Mihaltan, Giulia De Feo, F. E. R. Simons, A. Blua, B. Mahboub, D. Ryan, M. Bewick, Anabela Mota-Pinto, J.A. Fonseca, Neil Wilson, Marek Jutel, Dennis M. Williams, M. Akdis, Menachem Rottem, Marcello Persico, J. C. Ivancevich, Nelson Rosario, A. Farsi, Alvaro A. Cruz, Liguo Zhang, Anna Bedbrook, L. Bertorello, Magnus Wickman, Marilyn Urrutia-Pereira, O. Spranger, René Maximiliano Gómez, C. Bachert, Renaud Louis, Musa Khaitov, C. Stellato, Constantinos Pitsios, Roland Buonaiuto, A. Romano, Sîan A Williams, R. Puy, Daniela Rivero-Yeverino, Y. Mohammad, J. Farrell, Jan Brozek, Ricardo Pio Monti, E. Paulino, J. Correia de Sousa, Miguel Alejandro Medina-Ávalos, Jocelyne Just, Peter Valentin Tomazic, Jean-François Ferrero, Antoine Magnan, S. Waserman, J Rosado-Pinto, Maciek Kupczyk, C.S. Bosnic-Anticevich, T. Dedeu, Tommi Vasankari, R. Mösges, Robin O'Hehir, Ema Paulino, Peter Hellings, A. Neou, M. Wickman, D. Lauri, Jean Bousquet, A. Ciceran, Jacques Bouchard, Yehia El-Gamal, M.G. Dominguez-Silva, M.R. Alberti, Jean-Louis Pépin, Kimi Okubo, Juan Carlos Ivancevich, Patrik Eklund, Benoit Pugin, C. Dario, Mussa Khaitov, Luisa Brussino, A.G. Chuchalin, Elísio Costa, Susanna Palkonen, Lars Münter, Pedro Carreiro-Martins, R.E. Pulido Ross, Ettore Novellino, Kai-Håkon Carlsen, María Antonieta Guzmán, G.W. Canonica, Gabriel Onorato, Giuseppe De Carlo, R.E. Roller-Wirnsberger, Brian J. Lipworth, M. A. Guzman, J.N. Tebyriçá, Adnan Custovic, Yoshitaka Okamoto, Rimantas Stukas, P. Manning, J. Sastre-Dominguez, Caroline L.S. George, Robyn E O'Hehir, K. Maciej, Bassam Mahboub, J. F. Fontaine, Arũnas Valiulis, Xavier Rodó, D. Vicheva, G. Canfora, Vitalis Briedis, S. Rodrigues Valle, Mark S. Dykewicz, Joanne Rimmer, G. Castellano, B. Pigearias, A. L. Boner, Yunuen Rocío Huerta-Villalobos, Christine Rolland, H. Neffen, H. Arshad, Javier Gómez-Vera, P. Moura Santo, Frederic Viart, F. Blasi, J. Garcia-Aymerich, Lorenzo Cecchi, V. Niedeberger, Giorgio Ciprandi, F. Caballero-Fonseca, Jean-François Fontaine, J Mullol, Maurizio Romano, M. Viegi, Mario E. Zernotti, Arunas Valiulis, Anna Asarnoj, Antonio Nieto, J. Lavrut, D. Dokic, V. Kvedariene, Ewa Jassem, Cezmi A. Akdis, Ruth Murray, Claus Bachert, Peter Schmid-Grendelmeier, Emilie Burte, Joaquim Mullol, Guido Iaccarino, J. Kleine-Tebbe, P. V. Tomazic, E. Eller, Alessandro Fiocchi, H.J. Schunemann, M. Sorlini, C. Robalo-Cordeiro, Ana-Maria Todo-Bom, J. Brozek, Marco Nalin, Matteo Bonini, J. C. Sisul, S.E. Dahlen, F. Amat, Juan Carlos Sisul, Jawad Hajjam, Ana Todo-Bom, Enrica Menditto, Bousquet J., Hellings P.W., Agache I., Amat F., Annesi-Maesano I., Ansotegui I.J., Anto J.M., Bachert C., Bateman E.D., Bedbrook A., Bennoor K., Bewick M., Bindslev-Jensen C., Bosnic-Anticevich S., Bosse I., Brozek J., Brussino L., Canonica G.W., Cardona V., Casale T., Cepeda Sarabia A.M., Chavannes N.H., Cecchi L., Correia de Sousa J., Costa E., Cruz A.A., Czarlewski W., De Carlo G., De Feo G., Demoly P., Devillier P., Dykewicz M.S., El-Gamal Y., Eller E.E., Fonseca J.A., Fontaine J.-F., Fokkens W.J., Guzman M.-A., Haahtela T., Illario M., Ivancevich J.-C., Just J., Kaidashev I., Khaitov M., Kalayci O., Keil T., Klimek L., Kowalski M.L., Kuna P., Kvedariene V., Larenas-Linnemann D., Laune D., Le L.T.T., Carlsen K.L., Lourenco O., Mahboub B., Mair A., Menditto E., Milenkovic B., Morais-Almeida M., Mosges R., Mullol J., Murray R., Naclerio R., Namazova-Baranova L., Novellino E., O'Hehir R.E., Ohta K., Okamoto Y., Okubo K., Onorato G.L., Palkonen S., Panzner P., Papadopoulos N.G., Park H.-S., Paulino E., Pawankar R., Pfaar O., Plavec D., Popov T.A., Potter P., Prokopakis E.P., Rottem M., Ryan D., Salimaki J., Samolinski B., Sanchez-Borges M., Schunemann H.J., Sheikh A., Sisul J.-C., Rajabian-Soderlund R., Sooronbaev T., Stellato C., To T., Todo-Bom A.-M., Tomazic P.-V., Toppila-Salmi S., Valero A., Valiulis A., Valovirta E., Ventura M.-T., Wagenmann M., Wang D.Y., Wallace D., Waserman S., Wickman M., Yorgancioglu A., Zhang L., Zhong N., Zidarn M., Zuberbier T., Aberer W., Akdis C.A., Akdis M., Alberti M.R., Almeida R., Angles R., Arnavielle S., Asayag E., Asarnoj A., Arshad H., Avolio F., Bacci E., Baiardini I., Barbara C., Barbagallo M., Baroni I., Barreto B.A., Basagana X., Bedolla-Barajas M., Beghe B., Bel E.H., Bergmann K.C., Benson M., Bertorello L., Bialoszewski A.Z., Bieber T., Bialek S., Bjermer L., Blain H., Blasi F., Blua A., Bochenska Marciniak M., Bogus-Buczynska I., Boner A.L., Bonini M., Bonini S., Bouchard J., Boulet L.P., Bourret R., Braido F., Briedis V., Brightling C.E., Bucca C., Buhl R., Buonaiuto R., Panaitescu C., Burguete Cabanas M.T., Burte E., Bush A., Caballero-Fonseca F., Caillot D., Caimmi D., Calderon M.A., Camargos P.A.M., Camuzat T., Canfora G., Carreiro-Martins P., Carriazo A.M., Carr W., Cartier C., Castellano G., Chen Y., Chiron R., Chivato T., Chkhartishvili E., Chuchalin A.G., Chung K.F., Ciaravolo M.M., Ciceran A., Cingi C., Ciprandi G., Carvalho Coehlo A.C., Colas L., Colgan E., Coll J., Conforti D., Cortes-Grimaldo R.M., Corti F., Costa-Dominguez M.C., Courbis A.L., Cox L., Crescenzo M., Custovic A., Dahlen S.E., Dario C., da Silva J., Dauvilliers Y., Darsow U., De Blay F., Dedeu T., de Fatima Emerson M., De Vries G., De Martino B., de Paula Motta Rubini N., Deleanu D., Denburg J.A., Di Capua Ercolano S., Di Carluccio N., Didier A., Dokic D., Dominguez-Silva M.G., Douagui H., Dray G., Dubakiene R., Durham S.R., Du Toit G., Eklund P., Emuzyte R., Farrell J., Farsi A., Ferreira de Mello J., Ferrero J., Fink-Wagner A., Fiocchi A., Forti S., Fuentes-Perez J.M., Galvez-Romero J.L., Gamkrelidze A., Garcia-Aymerich J., Garcia-Cobas C.Y., Garcia-Cruz M.H., Gemicioglu B., Genova S., George C., Gereda J.E., Gerth van Wijk R., Gomez R.M., Gomez-Vera J., Gonzalez Diaz S., Gotua M., Grisle I., Guidacci M., Guldemond N.A., Gutter Z., Hajjam J., Hernandez L., Hourihane J.O., Huerta-Villalobos Y.R., Humbert M., Iaccarino G., Jares E.J., Jassem E., Johnston S.L., Joos G., Jung K.S., Jutel M., Kalyoncu A.F., Karjalainen J., Kardas P., Keith P.K., Khaltaev N., Kleine-Tebbe J., Kuitunen M., Kull I., Kupczyk M., Krzych-Falta E., Lacwik P., Lauri D., Lavrut J., Lessa M., Levato G., Li J., Lieberman P., Lipiec A., Lipworth B., Lodrup Carlsen K.C., Louis R., Luna-Pech J.A., Maciej K., Magnan A., Maier D., Majer I., Malva J., Mandajieva E., Manning P., De Manuel Keenoy E., Marshall G.D., Masjedi M.R., Maspero J.F., Mathieu-Dupas E., Matta Campos J.J., Matos A.L., Maurer M., Mavale-Manuel S., Mayora O., Medina-Avalos M.A., Melen E., Melo-Gomes E., Meltzer E.O., Mercier J., Miculinic N., Mihaltan F., Moda G., Mogica-Martinez M.D., Mohammad Y., Momas I., Montefort S., Monti R., Mora Bogado D., Morato-Castro F.F., Mota-Pinto A., Moura Santo P., Munter L., Muraro A., Nadif R., Nalin M., Napoli L., Neffen H., Niedeberger V., Nekam K., Neou A., Nieto A., Nogueira-Silva L., Nogues M., Nyembue T.D., Odzhakova C., Ortega Cisneros M., Ouedraogo S., Pali-Scholl I., Papi A., Passalacqua G., Pedersen S., Pepin J.L., Pereira A.M., Persico M., Phillips J., Picard R., Pigearias B., Pin I., Pitsios C., Pohl W., Portejoie F., Pozzi A.C., Price D., Puy R., Pugin B., Pulido Ross R.E., Przemecka M., Rabe K.F., Raciborski F., Reitsma S., Ribeirinho I., Rimmer J., Rivero-Yeverino D., Rizzo J.A., Rizzo M.C., Robalo-Cordeiro C., Rodenas F., Rodo X., Rodriguez Gonzalez M., Rodriguez-Manas L., Rolland C., Rodrigues Valle S., Roman Rodriguez M., Romano A., Rodriguez-Zagal E., Rolla G., Roller-Wirnsberger R.E., Romano M., Rosado-Pinto J., Rosario N., Sagara H., Sastre-Dominguez J., Scadding G.K., Scichilone N., Schmid-Grendelmeier P., Serpa F.S., Shamai S., Sierra M., Simons F.E.R., Siroux V., Skrindo I., Sole D., Somekh D., Sondermann M., Sova M., Sorensen M., Sorlini M., Spranger O., Stelmach R., Stukas R., Sunyer J., Strozek J., Szylling A., Tebyrica J.N., Thibaudon M., Trama U., Triggiani M., Suppli Ulrik C., Urrutia-Pereira M., Valenta R., van Eerd M., van Ganse E., van Hague M., Vandenplas O., Vezzani G., Vasankari T., Vatrella A., Verissimo M.T., Viart F., Viegi M., Vicheva D., Vontetsianos T., Walker S., Werfel T., Westman M., Williams D.M., Williams S., Wilson N., Wright J., Wroczynski P., Yakovliev P., Yawn B.P., Yiallouros P.K., Yusuf O.M., Zar H.J., Zernotti M.E., Zubrinich C., Zurkuhlen A., Bousquet, Jean, Hellings, Peter W., Agache, Ioana, Amat, Flore, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Clau, Bateman, Eric D., Bedbrook, Anna, Bennoor, Kazi, Bewick, Mickael, Bindslev-Jensen, Carsten, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Brozek, Jan, Brussino, Luisa, Canonica, Giorgio W., Cardona, Victoria, Casale, Thoma, Cepeda Sarabia, Alfonso M., Chavannes, Niels H., Cecchi, Lorenzo, Correia de Sousa, Jaime, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, De Carlo, Giuseppe, De Feo, Giulia, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S., El-Gamal, Yehia, Eller, Esben E., Fonseca, Joao A., Fontaine, Jean-Françoi, Fokkens, Wytske J., Guzmán, Maria-Antonieta, Haahtela, Tari, Illario, Maddalena, Ivancevich, Juan-Carlo, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Kalayci, Omer, Keil, Thoma, Klimek, Ludger, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Desiree, Laune, Daniel, Le, Lan T. T., Carlsen, Karin Lodrup, Lourenço, Olga, Mahboub, Bassam, Mair, Alpana, Menditto, Enrica, Milenkovic, Branislava, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Murray, Ruth, Naclerio, Robert, Namazova-Baranova, Leyla, Novellino, Ettore, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Onorato, Gabrielle L., Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikos G., Park, Hae-Sim, Paulino, Ema, Pawankar, Ruby, Pfaar, Oliver, Plavec, Davor, Popov, Ted A., Potter, Paul, Prokopakis, Emmanuel P., Rottem, Menachem, Ryan, Dermot, Salimäki, Johanna, Samolinski, Boleslaw, Sanchez-Borges, Mario, Schunemann, Holger J., Sheikh, Aziz, Sisul, Juan-Carlo, Rajabian-Söderlund, Rojin, Sooronbaev, Talant, Stellato, Cristiana, To, Teresa, Todo-Bom, Ana-Maria, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Aruna, Valovirta, Erkka, Ventura, Maria-Teresa, Wagenmann, Martin, Wang, De Yun, Wallace, Dana, Waserman, Susan, Wickman, Magnu, Yorgancioglu, Arzu, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Zuberbier, Torsten, Bousquet, J., Hellings, P. W., Aberer, W., Agache, I., Akdis, C. A., Akdis, M., Alberti, M. R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Bachert, C., Baiardini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B. A., Basagana, X., Bateman, E. D., Bedolla-Barajas, M., Bedbrook, A., Bewick, M., Beghé, B., Bel, E. H., Bergmann, K. C., Bennoor, K. S., Benson, M., Bertorello, L., Białoszewski, A. Z., Bieber, T., Bialek, S., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Blua, A., Bochenska Marciniak, M., Bogus-Buczynska, I., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevich, C. S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briedis, V., Brightling, C. E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Burguete Cabañas, M. T., Burte, E., Bush, A., Caballero-Fonseca, F., Caillot, D., Caimmi, D., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Canfora, G., Canonica, G. W., Cardona, V., Carlsen, K. H., Carreiro-Martins, P., Carriazo, A. M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda Sarabia, A. M., Chavannes, N. H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciaravolo, M. M., Ciceran, A., Cingi, C., Ciprandi, G., Carvalho Coehlo, A. C., Colas, L., Colgan, E., Coll, J., Conforti, D., Correia de Sousa, J., Cortés-Grimaldo, R. M., Corti, F., Costa, E., Costa-Dominguez, M. C., Courbis, A. L., Cox, L., Crescenzo, M., Cruz, A. A., Custovic, A., Czarlewski, W., Dahlen, S. E., Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., de Fátima Emerson, M., De Feo, G., De Vries, G., De Martino, B., de Paula Motta Rubini, N., Deleanu, D., Demoly, P., Denburg, J. A., Devillier, P., Di Capua Ercolano, S., Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M. G., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., El-Gamal, Y., Eklund, P., Eller, E., Emuzyte, R., Farrell, J., Farsi, A., Ferreira de Mello, J., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fokkens, W. J., Fonseca, J. A., Fontaine, J. F., Forti, S., Fuentes-Perez, J. M., Gálvez-Romero, J. L., Gamkrelidze, A., Garcia-Aymerich, J., García-Cobas, C. Y., Garcia-Cruz, M. H., Gemicioğlu, B., Genova, S., George, C., Gereda, J. E., Gerth van Wijk, R., Gomez, R. M., Gómez-Vera, J., González Diaz, S., Gotua, M., Grisle, I., Guidacci, M., Guldemond, N. A., Gutter, Z., Guzmán, M. A., Haahtela, T., Hajjam, J., Hernández, L., Hourihane, J. O. 'B., Huerta-Villalobos, Y. R., Humbert, M., Iaccarino, G., Illario, M., Ivancevich, J. C., Jares, E. J., Jassem, E., Johnston, S. L., Joos, G., Jung, K. S., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Kardas, P., Keil, T., Keith, P. K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., Kowalski, M. L., Kuitunen, M., Kull, I., Kuna, P., Kupczyk, M., Kvedariene, V., Krzych-Fałta, E., Lacwik, P., Larenas-Linnemann, D., Laune, D., Lauri, D., Lavrut, J., Le, L. T. T., Lessa, M., Levato, G., Li, J., Lieberman, P., Lipiec, A., Lipworth, B., Lodrup Carlsen, K. C., Louis, R., Lourenço, O., Luna-Pech, J. A., Maciej, K., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maspero, J. F., Mathieu-Dupas, E., Matta Campos, J. J., Matos, A. L., Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M. A., Melén, E., Melo-Gomes, E., Meltzer, E. O., Menditto, E., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M. D., Mohammad, Y., Momas, I., Montefort, S., Monti, R., Mora Bogado, D., Morais-Almeida, M., Morato-Castro, F. F., Mösges, R., Mota-Pinto, A., Moura Santo, P., Mullol, J., Münter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, T. D., O'Hehir, R. E., Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G. L., Ortega Cisneros, M., Ouedraogo, S., Pali-Schöll, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Park, H. S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pépin, J. L., Pereira, A. M., Persico, M., Pfaar, O., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Pozzi, A. C., Price, D., Prokopakis, E. P., Puy, R., Pugin, B., Pulido Ross, R. E., Przemecka, M., Rabe, K. F., Raciborski, F., Rajabian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Rivero-Yeverino, D., Rizzo, J. A., Rizzo, M. C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Rodriguez Gonzalez, M., Rodriguez-Mañas, L., Rolland, C., Rodrigues Valle, S., Roman Rodriguez, M., Romano, A., Rodriguez-Zagal, E., Rolla, G., Roller-Wirnsberger, R. E., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Sagara, H., Salimäki, J., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schunemann, H. J., Scichilone, N., Schmid-Grendelmeier, P., Serpa, F. S., Shamai, S., Sheikh, A., Sierra, M., Simons, F. E. R., Siroux, V., Sisul, J. C., Skrindo, I., Solé, D., Somekh, D., Sondermann, M., Sooronbaev, T., Sova, M., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyriçá, J. N., Thibaudon, M., To, T., Todo-Bom, A., Tomazic, P. V., Toppila-Salmi, S., Trama, U., Triggiani, M., Suppli Ulrik, C., Urrutia-Pereira, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., van Ganse, E., van Hague, M., Vandenplas, O., Ventura, M. T., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M. T., Viart, F., Viegi, M., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B. P., Yiallouros, P. K., Yorgancioglu, A., Yusuf, O. M., Zar, H. J., Zhang, L., Zhong, N., Zernotti, M. E., Zidarn, M., Zuberbier, T., Zubrinich, C., Zurkuhlen, A., CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Laboratory of clinical immunology, Department of Allergy and Clinical Immunology, Transylvania University of Brasov, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Epidémiologie, Systèmes d'Information, Modélisation, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Department of Allergy and Immunology, Hospital Quirónsalud Bizkaia [Bilbao], Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hacettepe University = Hacettepe Üniversitesi, Mechanobiology Institute [Singapore] (MBI), National University of Singapore (NUS), Department of Clinical Epidemiology and Biostatistics and Medicine, McMaster University [Hamilton, Ontario], Department of Dermatology [Graz, Austria], Medical University Graz, Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Department Engineering Quimica (ICEMS), Ghent University Hospital, Istituto Nazionale di Fisica Nucleare, sezione di Bari (INFN, sezione di Bari), Istituto Nazionale di Fisica Nucleare (INFN), IMIM-Hospital del Mar, Generalitat de Catalunya, University of Cape Town, Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton-School of Medicine, Centre de gérontologie, Department of Pathophysiology and Transplantation, Università degli Studi di Milano = University of Milan (UNIMI), Istituto di Geoscienze e Georisorse, Pavia, Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II = Università degli studi di Napoli Federico II, Woolcock Institute of Medical Research [Sydney], The University of Sydney, Université Laval [Québec] (ULaval), Departments of Clinical Epidemiology and Biostatistics and Medicine [Ontario], Service greffe de moelle osseuse, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Royal Brompton Hospital, Région Languedoc-Roussillon-Midi-Pyrénées, Vall d'Hebron University Hospital [Barcelona], University of South Florida [Tampa] (USF), Università degli Studi di Firenze = University of Florence (UniFI), University of Michigan, Department of Atmospheric, Centres de Ressources et de Compétences de la Mucoviscidose [Montpellier] (CRCM [Montpellier]), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve-Service des Maladies Respiratoires, Russian State Medical University, Universidade do Porto, Instituto de Biologia Molecular e Celular (IBMC), UCB Pharma, Colombes, Hôpital Gui de Chauliac [CHU Montpellier], CHU Strasbourg, European Federation of Allergy (EFA), Airways Diseases Patients' Associations, Università degli Studi di Salerno = University of Salerno (UNISA), Laboratoire de recherche sur les mécanismes moléculaires et pharmacologiques de l’obstruction bronchique (LOBIP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Linköping University (LIU), Department of Dermatology and Allergy Centre, Odense University Hospital, Vilnius University [Vilnius], Center of Research in Health Technologies and Information Systems (CINTESIS), Universidade do Porto = University of Porto, Institut d'Electronique du Solide et des Systèmes (InESS), Centre National de la Recherche Scientifique (CNRS), Son Pisa Primary Care Centre, IB-Salut Balearic Health Service, Center for Allergy and Immunology Research [Tbilisi], Department of Dermatology, Helsinki University Hospital-Skin and Allergy Hospital, Swedish Meteorological and Hydrological Institute (SMHI), CORYSS-TESS, Ukrainina Medical Stomatological Academy [Poltava, Ukraine], Institute of Social Medicine, Epidemiology and Health Economics-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Biologie des organismes marins et écosystèmes (BOME), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), NRC Institute of immunology FMBA, Moscow Russian federation, Allergy and Asthma Center Westend, German Society for Otorhinolaryngology HNS, Rheinische Friedrich-Wilhelms-Universität Bonn, The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Medical University of Łódź (MUL), Hospital Medica Sur, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Applied Physical Chemistry Laboratory (APCLab), Institute of Geophysics and Planetary Physics [Los Angeles] (IGPP), University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), Équipe de Recherche en Textes, Informatique, Multilinguisme (ERTIM), Institut National des Langues et Civilisations Orientales (Inalco), Institute of Oceanology [China], University of Beira Interior [Portugal] (UBI), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Pulmonary and allergy unit, American University of Sharjah-Rashid Hospital-Dubai Health Authority (DHA), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Sysdiag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic (SysDiag ), BIO-RAD-Centre National de la Recherche Scientifique (CNRS), 'Federico II' University of Naples Medical School, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Pneumology Department, Marius Nasta Institute of Pneumology, Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw - Poland-Faculté de Pharmacie de Paris, Allergy and Clinical Immunology Department, Hospital CUF Descobertas, Universität zu Köln = University of Cologne, Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Section of Otolaryngology-Head & Neck Surgery (OHNS), University of Chicago, Department of Pharmacy Naples, Université de Naples, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital-Monash University Building, AMREP, Dept. of Electronic Engineering, Chubu University, Department of Otorhinolaryngology, Chiba University Hospital, Department of Allergology and Clinical Immunology, Charles University [Prague] (CU)-Medical Faculty in Pilsen, Department of Earth and Planetary Sciences [Cambridge, USA] (EPS), Harvard University, Allergy and Respiratory Diseases, Università degli studi di Genova = University of Genoa (UniGe), Department of Pediatrics, Nippon Medical School, Centre Hospitalier Universitaire [Grenoble] (CHU), Department of Otorhinolaryngology, Head and Neck Surgery [Mannheim, Germany], University Hospital Mannheim, Laboratoire de physique et chimie des nano-objets (LPCNO), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), CHU Grenoble, Children’s Hospital Srebrnjak [Zagreb, Croatia], Department of Physics [UMIST Manchester], University of Manchester Institute of Science and Technology (UMIST), Laboratori Nazionali del Sud (LNS), Getafe University Hospital, Madrid, Karl-Franzens-Universität Graz, Ecologie comportementale (EC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes (UR)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Allergy Asthma and Immunology [Haifa, Israel], Ha'Emek Medical Center, Afula-Rappaport Faculty of Medicine, University of Edinburgh, Medical University of Warsaw - Poland, Department of Allergy and Clinical Immunology [Caracas, Venezuela], Centro Médico Docente La Trinidad, Department of Computer Science [Haifa], University of Haifa [Haifa], Allergy and Respiratory Research Group, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), National Centre of Cardiology and Internal Medicine, Ministry of Health Kyrgyz Republic, Réseau National de Surveillance Aérobiologique (RNSA), Berkeley Seismological Laboratory, Division of Clinical Immunology and Allergy, University of Naples Federico II = Università degli studi di Napoli Federico II, CIRCE, Ctr Res Energy Resources & Consumpt, Zaragoza 50018, Spain, Vilnius University Clinic of Children's Diseases, Suomen Terveystalo Allergy Clinic, Health Service and Performance Research (HESPER), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre d'EPistémologie et d'ERgologie Comparatives (CEPERC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institute for Climate and Atmospheric Science [Leeds] (ICAS), School of Earth and Environment [Leeds] (SEE), University of Leeds-University of Leeds, Nova Southeastern University (NSU), Department of Otolaryngology, National University of Singapore (NUS)-Yong Loo Lin School of Medicine, Sachs' Children's Hospital, IAES, Department of Pulmonology, Manisa Celal Bayar University, Center for Evolutionary and Theoretical Immunology [Albuquerque, New Mexico] (CETI), The University of New Mexico [Albuquerque], National Key State Laboratory for ThermoStructural Composites (TSCM), Northwestern Polytechnical University [Xi'an] (NPU), Respiratory and Allergic Diseases, University Clinic of Respiratory and Allergic Diseases Golnik, University Hospital of Cologne [Cologne], Supported by the European Innovation Partnership on Active and Healthy Ageing and POLLAR (EIT Health, European Union)., European Project: 643803,H2020,H2020-HCO-2014,PROEIPAHA(2015), UCL - (MGD) Service de pneumologie, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidemiology of Allergic and Respiratory Diseases Department [Paris] (EPAR), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospital Quiròn Bizkaia Erandio, Université Pierre et Marie Curie - Paris 6 (UPMC), University of Milan, University of Naples Federico II-CNR, Rome, Italy and Department of Medicine, Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Hôpital Gui de Chauliac, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Università degli Studi di Salerno (UNISA), Institut de Physique du Globe de Paris (IPGP), Centre National de la Recherche Scientifique (CNRS)-Université de La Réunion (UR)-Université Paris Diderot - Paris 7 (UPD7)-IPG PARIS-Institut national des sciences de l'Univers (INSU - CNRS), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]-Epidemiology and Health Economics, Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN), University of California-University of California, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospital CUF-Descobertas, Universität zu Köln, Medical Faculty in Pilsen-Charles University in Prague - the First Faculty of Medicine, Harvard University [Cambridge], University of Genoa (UNIGE), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Graz, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université Claude Bernard Lyon 1 (UCBL), Centro Medico-Docente La Trinidad, Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Università degli studi di Napoli Federico II, Center for Evolutionary and theoretical Immunology, Biology, National Institute for Health Research, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II, Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Karl-Franzens-Universität [Graz, Autriche], Department of Dermatology, Allergology and Venereology, Clinicum, University of Helsinki, Children's Hospital, Faculty of Law, HUS Children and Adolescents, HUS Inflammation Center, University Hospitals Leuven [Leuven], Universitat Pompeu Fabra [Barcelona]-Catalunya ministerio de salud, University of Zürich [Zürich] (UZH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), University of South Florida (USF), Università degli Studi di Firenze = University of Florence [Firenze], Laboratoire Magmas et Volcans (LMV), Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Universidade do Porto [Porto], Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin -Epidemiology and Health Economics, Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Sondra, CentraleSupélec, Université Paris-Saclay (COmUE) (SONDRA), ONERA-CentraleSupélec-Université Paris Saclay (COmUE), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), RNSA, Centre d'EPistémologie et d'ERgologie Comparatives - UMR 7304 (CEPERC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Ear, Nose and Throat, AII - Inflammatory diseases, Pulmonology, Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), National Institute for Nuclear Physics (INFN), Université Laval, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Università degli Studi di Firenze [Firenze], University of Salerno (UNISA), Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Sondra, CentraleSupélec, Université Paris-Saclay (SONDRA), ONERA-CentraleSupélec-Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), École normale supérieure - Paris (ENS Paris)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1), Universidade do Minho, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, uBibliorum, and Internal Medicine

Subjects
Allergy, Medicina Básica [Ciências Médicas], asthma -- guideline, Allergic asthma, DECISION-MAKING, Allergic Rhinitis and Its Impact on Asthma, GUIDELINES, Medical and Health Sciences, Medical Records, 0302 clinical medicine, Health care, Immunology and Allergy, 030212 general & internal medicine, asthma, Change management, rhinitis, Immunology, MASK-RHINITIS, ComputingMilieux_MISCELLANEOUS, Rinitis, mobilne aplikacije, upravljanje sprememb, Medical record, GLOBAL STRATEGY, WORK PRODUCTIVITY, Telemedicine, mobile applications, 3. Good health, Asma alérgica, rhiniti, 1107 Immunology, Ciências Médicas::Medicina Básica, klinične poti, allergic -- guideline, Life Sciences & Biomedicine, Human, PATIENT PARTICIPATION, Allergic Rhinitis, medicine.medical_specialty, animal structures, multimorbidity, EUROPEAN INNOVATION PARTNERSHIP, Change Management, [object Object], Settore MED/10 - Malattie Dell'Apparato Respiratorio, Asthma/diagnosis, CHRONIC DISEASES, MACVIA-ARIA, 03 medical and health sciences, medicine, multimorbidnost, QUALITY, Humans, critical pathways, astma -- smernica, Patient participation, Asma, udc:616.2, Asthma, Science & Technology, ARIA, business.industry, Multimorbidity, Rhinitis, Allergic, Settore MED/09 - MEDICINA INTERNA, change management, Mobile Airways Sentinel Network (MASK) Study Group, Guideline, ta3121, medicine.disease, Rinite alérgica, Rhinitis, Allergic/diagnosis, Integrated care, alergijski rinitis -- smernica, Allergic Rhinitis and Its Impact on Asthma, asthma, Change management, rhinitis, Immunology and Allergy, Immunology, 030228 respiratory system, Family medicine, 3121 General medicine, internal medicine and other clinical medicine, Medical Record, Clinical Medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Impact on Asthma
Abstract

Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional., EAACI -European Academy of Allergy and Clinical Immunology(undefined), info:eu-repo/semantics/acceptedVersion

Published
2018
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31. Medicinal bioactivites and allergenic properties of pumpkin seeds: review upon a pediatric food anaphylaxis case report

Author

J.P. Jacquier, C. Chatain, Marie-Thérèse Leccia, I. Pin, and P. Pralong

Subjects
0301 basic medicine, Male, Epinephrine, 03 medical and health sciences, 0302 clinical medicine, food, Cucurbita, Food allergy, Food anaphylaxis, Botany, medicine, Immunology and Allergy, Animals, Humans, Child, Anaphylaxis, chemistry.chemical_classification, 030201 allergy, 030109 nutrition & dietetics, Pumpkin seed, Traditional medicine, business.industry, digestive, oral, and skin physiology, food and beverages, Antigens, Plant, Intradermal Tests, medicine.disease, food.food, Treatment Outcome, chemistry, Seeds, business, Cucurbitaceae, Food Hypersensitivity, Polyunsaturated fatty acid
Abstract

Summary Food allergy to pumpkin seed is considered very rare, and only some isolated case reports have so far been published. We report here a case of food anaphylaxis to pumpkin seed in an eight-year-old boy, who tolerated all other edible seeds, peanut and tree nuts, as well as pulp of different kinds of pumpkins and other fruits of the Cucurbitaceae family. From this observation, a review of the botanical, historical, medicinal and allergenic aspects of pumpkin and its seeds is proposed. With the advent of diets rich in omega-3 and omega-6 polyunsaturated fatty acids, edible seeds like pumpkin seed have been incorporated in the modern diet. Their incremental use in the food-processing industry might contribute to an increase in food allergy to pumpkin seed in the future.

Published
2017

32. WITHDRAWN: Scaling up strategies of the Chronic Respiratory Disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3 – Area 5)

Author

M. Nogues, David Price, Tari Haahtela, Bianca Beghe, John Wright, Josep M. Antó, J. O'b. Hourihane, K. C. Lødrup Carlsen, Justin Michel, June Roberts, Robert M. Naclerio, M. Roman Rodriguez, Amiran Gamkrelidze, P. Manning, Panayiotis K. Yiallouros, John Farrell, Gérard Dray, A. Ben Kheder, Branislava Milenkovic, W. J. Fokkens, Susanne Lau, Ronald Dahl, J. E. Gereda, Pma Calverley, O. Jonquet, D. Poethig, Erkka Valovirta, Z. Gutter, Grégory Ninot, Yehia El-Gamal, M. van Hage, Claus Vogelmeier, S. Mara, P. Matignon, Talant Sooronbaev, Ratko Djukanovic, Carel Thijs, Davide Caimmi, Ralph Mösges, G. Moda Y. Mohammad, Friedrich Horak, Joachim Heinrich, Y. Z. Chen, Leonardo M. Fabbri, Y. Magard, B. Pigearias, F. Rodenas, A.G. Chuchalin, NM Siafakas, Rodolphe Bourret, A. L. Boner, A. Fink Wagner, T. Similowski, Diana Deleanu, I. Skrindo, Ulf Darsow, Bilun Gemicioglu, Stephen R. Durham, S.I. Rennard, Mohammad Reza Masjedi, Arunas Valiulis, S. Gonzalez Diaz, Brian J. Lipworth, Philip Lieberman, Christine Rolland, H. Neffen, Pierluigi Paggiaro, Henriette A. Smit, Bart N. Lambrecht, P. Devillier, Bodo Niggemann, D. Dokic, Dennis M. Williams, M. Akdis, R. Pengelly, Bassam Mahboub, Oliver Pfaar, Cezmi A. Akdis, L. Namazova-Baranova, Lanny J. Rosenwasser, Hans F. Merk, B. P. Yawn, Alpana Mair, Thomas B. Casale, Claus Bachert, Cristina Bárbara, Martin Wagenmann, Francesco Forastiere, T. Dedeu, Shona Pedersen, Giorgio Walter Canonica, Antonio Valero, Werner Aberer, Andrew Briggs, Alberto Papi, Peter Burney, Paulo Augusto Moreira Camargos, D. J. Costa, Magnus Wickman, Hans-Ulrich Schulz, T. Strandberg, T. Camuzat, Michael E. Hyland, Mario Sánchez-Borges, L. T. T. Le, N. Khaltaev, Lawrence Grouse, O. Spranger, F. de Blay, H. Douagui, Ki-Suck Jung, R. Picard, S. Repka-Ramirez, Philippe-Jean Bousquet, A. Yorgancioglu, U. Wahn, J. Garcia-Aymerich, Kaja Julge, D. Plavec, A. Bedbrook, Torsten Zuberbier, A. Romano, Sîan A Williams, Monica Fletcher, Mark S. Dykewicz, A. Montilla-Santana, B. Samolinski, Joël Ankri, Albert Alonso, Filip Raciborski, Antonella Muraro, Kian Fan Chung, L. Rodriguez Manas, Rafael Stelmach, G. Passalacqua, José Roberto Jardim, K. Ohta, Renaud Louis, Rudolph Valenta, M. Gotua, Massimo Triggiani, E. Melo-Gomes, Y. Okamoto, William MacNee, Ludger Klimek, Holger J. Schünemann, Dirkje S. Postma, Hasan Arshad, Gailen D. Marshall, M. Adachi, Nikolaos G. Papadopoulos, Mikael Benson, Kai-Håkon Carlsen, E. Chkhartishvili, Gerard H. Koppelman, R. Emuzyte, Chunxue Bai, Ruby Pawankar, Ana Todo-Bom, Claude Jeandel, Ilaria Baiardini, Osman M. Yusuf, Josep Roca, Giovanni Viegi, Pascal Demoly, Daniel Laune, S. E. Dahlen, Giorgio Ciprandi, M. Rottem, E. O. Meltzer, Sebastian L. Johnston, Mika J. Mäkelä, Edgardo Jares, Kimi Okubo, Paul K. Keith, Fulvio Braido, M. R. Kaitov, Alessandro Fiocchi, F. Caballero-Fonseca, Jørgen Vestbo, Carsten Bindslev-Jensen, Jing Li, Guy Joos, M. A. Guzman, S. Palkonen, K. Nekam, G. Vezzani, A. M. Cepeda Sarabia, Anh Tuan Dinh-Xuan, Adnan Custovic, C. Robalo-Cordeiro, Christine Jenkins, Niels H. Chavannes, E.H.D. Bel, A. Hendry, Neven Miculinic, T. Bieber, João O. Malva, Thomas Keil, Matteo Bonini, Klaus F. Rabe, F. Radier Pontal, F. Mihaltan, D. Y. Wang, J. C. Sisul, Benoit Wallaert, Teresa To, Robyn E O'Hehir, Jan Brozek, Ian D. Pavord, Luo Zhang, Nelson Rosario, Simon Walker, P H Howarth, J. Correia de Sousa, I. Majer, L.-P. Boulet, Marcus Maurer, J Mullol, S. Ouedraogo, Andrew Menzies-Gow, T. Vontetsianos, Mario E. Zernotti, Paul Potter, Mathieu Molimard, M. Morgan, Aziz Sheikh, Pakit Vichyanond, Isabella Pali-Schöll, Leif Bjermer, Peter Schmid-Grendelmeier, F. E. R. Simons, Antoine Magnan, T. D. Nyembue, J. Just, W. Carr, Leda Chatzi, I. Pin, E. Melen, Dirceu Solé, J. Garces, I. Grisle, Christopher E. Brightling, Peter Frith, E. Serrano, Inger Kull, F. Portejoie, M. Morais-Almeida, I. J. Ansotegui, G. De Carlo, K. S. Bennoor, S. Nafti, B. Hellquist-Dahl, Ali Fuat Kalyoncu, Dermot Ryan, J. Mercier, Marc Humbert, S. Bosnic-Anticevitch, Abay Baigenzhin, Olivier Vandenplas, Sakari Reitamo, M. Bewick, R. Chiron, Eric D. Bateman, Nanshan Zhong, Jordi Sunyer, Hubert Blain, O. Kalayci, Andrew Bush, D. Henderson, Désirée Larenas-Linnemann, K. C. Bergmann, J. C. Ivancevich, Bruno Vellas, Alvaro A. Cruz, A. Didier, M. Gaga, I. Annesi-Maesano, Maddalena Illario, P. Panzner, G. Crooks, Judah A. Denburg, Moises A. Calderon, Francesco Blasi, W. Pohl, Sergio Bonini, Ruta Dubakiene, Alvar Agusti, Violeta Kvedariene, G. K. Scadding, E. De Manuel Keenoy, E. Valia, S. Mavale-Manuel, Sylvie Arnavielhe, Piotr Kuna, Yves Sibille, Marek L. Kowalski, A. Zaidi, Todor A. Popov, V. Kolek, J Rosado-Pinto, Tommi Vasankari, Liam G Heaney, B. Koffi N'Goran, D. Heve, A. Neou, Isabelle Momas, Jean Bousquet, Igor Kaidashev, Hae-Sim Park, P W Hellings, Michael D. Shields, P. J. Sterk, Ana Maria Carriazo, João Fonseca, E. Van Ganse, Roland Buhl, L. Cox, Mihaela Zidarn, I. Cirule, and H. J. Zar

Subjects
Gerontology, medicine.medical_specialty, business.industry, Respiratory disease, Alternative medicine, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, General partnership, Action plan, medicine, General Earth and Planetary Sciences, 030212 general & internal medicine, Healthy ageing, business, General Environmental Science
Published
2017
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33. Immediate Effects of Acupuncture Treatment on Intra- and Inter-Limb Contributions to Body Support During Gait in Patients with Bilateral Medial Knee Osteoarthritis

Author

Ting-Ming Wang, Jaung-Geng Lin, Tung-Wu Lu, I-Pin Wei, and Yen-Hung Liu

Subjects
musculoskeletal diseases, Male, medicine.medical_specialty, Acupuncture Therapy, Osteoarthritis, Weight-Bearing, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Acupuncture, Medicine, Humans, Gait, Balance (ability), Aged, 030203 arthritis & rheumatology, business.industry, General Medicine, Acupuncture treatment, Middle Aged, Osteoarthritis, Knee, medicine.disease, Sagittal plane, Biomechanical Phenomena, Walking Speed, medicine.anatomical_structure, Electroacupuncture, Treatment Outcome, Complementary and alternative medicine, Gait analysis, Case-Control Studies, Physical therapy, Female, business, 030217 neurology & neurosurgery, Medial knee
Abstract

Knee osteoarthritis (OA) often leads to altered balance control, joint motion and loading patterns during gait. Acupuncture has been proven to be effective in pain relief but its effects on inter-joint load-sharing for body balance have not been reported. The current study bridged the gap by quantifying the immediate effects of acupuncture on the inter-joint and inter-limb load-sharing in patients with knee OA during level walking in terms of the total support moment (Ms) and the contribution of individual joints to the total support moment. Gait analysis was performed on fifteen healthy controls and on fifteen patients with mild to moderate bilateral medial knee OA. After acupuncture treatment the patients with bilateral knee OA walked with significantly increased speed ([Formula: see text]), and were able to resist greater and closer-to-normal knee flexion moments ([Formula: see text]). They also changed the inter-joint sharing of the support moments with increased knee ([Formula: see text]) contributions, but reduced hip contributions ([Formula: see text]) to the sagittal Ms during single-limb support. They showed an asymmetric inter-limb load-sharing similar to the normal controls, with increased sharing of the time integral of both the sagittal and frontal whole body support moment by the leading limb during double-limb support ([Formula: see text]). The altered intra- and inter-limb contributions to the demand of supporting the body during gait suggests that acupuncture treatment led to immediate changes in the control strategy toward a normal pattern. However, the effects of these changes on the progression of the disease in the long term would require further investigation.

Published
2017

34. Anaphylaxie alimentaire à la Mozzarella di Bufala Campana

Author

Marie-Thérèse Leccia, C. Chatain, J.P. Jacquier, V. Zambelli, I. Pin, and P. Pralong

Subjects
Immunology and Allergy
Abstract

Introduction Si l’allergie alimentaire aux laits de chevre et de brebis avec tolerance au lait de vache est rare mais connue, l’allergie au lait de bufflonne est exceptionnellement rapportee. Nous presentons un cas associant allergie alimentaire aux laits de brebis, de chevre et de bufflonne avec tolerance au lait de vache. Methodes Un garcon de 6 ans aux antecedents d’eczema, d’asthme, d’allergie alimentaire a l’arachide et aux laits de chevre et de brebis a presente 2 reactions allergiques de grade 2 apres consommation de mozzarella di Bufala Campana avec prurit, vomissement, dysphagie, dysphonie et asthme la 1re fois, et urticaire generalisee associee a des douleurs abdominales 6 mois plus tard. Le lait de vache est tolere sous toutes formes. Un test de reintroduction a ce fromage, propose 3 mois auparavant devant une suspicion d’allergie et un prick-test douteux, avait ete negatif a 56 g. La survenue progressive d’un prurit des oreilles ou pharynge a l’ingestion de cette mozzarella avait conduit a une consommation tres irreguliere. Resultats L’allergie est confirmee par un prick-test devenu positif a ce fromage associe a un prick-test negatif au lait de vache. Discussion Seulement 2 cas associant allergie au lait de brebis, de chevre et de bufflonne sans allergie au lait de vache, un cas d’allergie isolee au lait de bufflonne et un cas associant tolerance a ce lait et allergie au lait de vache ont ete rapportes dans la litterature. L’allergie aux laits de bufflonne, de chevre et de brebis sans allergie au lait de vache serait due a une sensibilisation a une β-caseine presentant une forte homologie entre les 3 premiers laits. Plus precisement, il pourrait s’agir d’une γ-caseine, une fraction de la β-caseine absente dans le lait de vache et dont la quantite augmente au cours de la fabrication de fromage a partir du lait frais. Une lactoglobuline specifique du lait de bufflonne pourrait egalement etre impliquee. Conclusion Devant une allergie aux laits de chevre et de brebis avec tolerance au lait de vache une sensibilisation au lait de bufflonne devrait systematiquement etre recherchee. L’inclusion de tous les laits de mammiferes dans la liste des 14 allergenes a declaration obligatoire serait souhaitable.

Published
2018
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36. [Translated article] Lymphovascular Invasion and High Mitotic Count Are Associated With Increased Risk of Recurrence in Pleomorphic Dermal Sarcoma

Author

M. Pons Benavent, E. Ríos-Viñuela, E. Nagore, C. Monteagudo, M. Aguerralde, D. Mata Cano, B. Llombart, C. Serra-Guillén, I. Pinazo Canales, C. Requena, and O. Sanmartín

Subjects
Sarcoma pleomórfico dérmico, Fibroxantoma atípico, Invasión linfovascular, Sarcoma pleomórfico, Mitosis, Dermatology, RL1-803, Internal medicine, RC31-1245
Abstract

Background and objective: Atypical fibroxanthoma and pleomorphic dermal sarcoma (PDS) are rare mesenchymal tumors. Due to the low incidence of PDS and a historically confusing nomenclature, little is known about the true aggressiveness of this tumor. The aim of this study was to investigate clinical and histologic risk factors for recurrence in PDS. Material and methods: Retrospective, observational, bicentric study of 31 PDSs diagnosed and treated at Hospital Clínico Universitario de Valencia and Instituto Valenciano de Oncología in Valencia, Spain, between 2005 and 2020. We described the clinical and histologic features of these tumors and performed univariate analysis and multivariate Cox regression analysis. Results: In the univariate analysis, tumor recurrence (P

Published
2023
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37. [Overnight polysomnography versus respiratory polygraphy in the diagnosis of pediatric obstructive sleep apnea]

Author

P, Franco, H, Bourdin, F, Braun, J, Briffod, I, Pin, and M-J, Challamel

Subjects
Sleep Apnea, Obstructive, Polysomnography, Humans, Child, Respiratory Function Tests
Abstract

The French Society of Research and Sleep Medicine (SFRMS) organized a meeting on obstructive sleep apnea syndrome (OSAS) in children. A multidisciplinary group of specialists (pulmonologists, ENT surgeons, pediatricians, neurophysiologists, sleep specialists) drew up a consensus document on the value of electrophysiological recordings in the diagnosis of OSAS in children. Technical considerations and recommended sensors, respiratory event definitions, and scoring criteria are presented according to the 2012 and 2014 recommendations of the American Academy of Sleep Medicine (AASM). Polysomnographic criteria for sleep-disordered breathing in children and the French National Authority for Health guidelines for indications of polysomnographic studies were reported. Relevance and limits of in-lab PSG, home PSG, and respiratory polygraphy were presented and guidelines were proposed to improve the diagnosis and follow-up of these children.

Published
2016

38. [Post-traumatic pulmonary aspergilloma]

Author

M, Isnard, E, Hullo, Y, Robert, C, Piolat, C, Durand, S, Lantuejoul, C, Garnaud, and I, Pin

Subjects
Adolescent, Lung Diseases, Fungal, Recurrence, Granuloma, Foreign-Body, Humans, Accidental Falls, Female, Lung Injury, Pulmonary Aspergillosis, Lung, Trees
Abstract

Aspergillomas occur due to colonization of a pre-existing pulmonary, bronchial or pleural cavity by Aspergillus spp. Often asymptomatic, this pathology can reveal itself by recurrent haemoptysis or when bacterial superinfections occur. Aspergillomas occurring in post-traumatic cavities are rare and their management is poorly codified.A child suffered from a chest wound at the age of 13 years. Two years later, investigation of recurrent haemoptysis revealed a residual pneumatocele in the right lower lobe colonized by Aspergillus spp. Initial treatment with systemic azole antifungals was unsuccessful because of digestive and ophthalmological intolerance. Surgical treatment by right lower lobectomy was finally decided on by the multidisciplinary team. This revealed an intrabronchial foreign body of vegetal type with cellulosic reinforcement, causing a polymorphic granulomatous reaction around, and associated with a proliferation of filamentous fungi including Aspergillus fumigatus. Surgery was followed by liposomal amphotericin B treatment for three weeks with a favourable outcome.This clinical case illustrates the benefits of surgical management of post-traumatic aspergillomas, even in children, in order to eradicate the aspergillus implant and to remove any foreign body to prevent recurrence.

Published
2016

39. MOESM1 of Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Author

J. Bousquet, J. Farrell, G. Crooks, P. Hellings, E. Bel, M. Bewick, N. Chavannes, J. Sousa, A. Cruz, T. Haahtela, G. Joos, N. Khaltaev, J. Malva, A. Muraro, M. Nogues, S. Palkonen, S. Pedersen, C. Robalo-Cordeiro, B. Samolinski, T. Strandberg, A. Valiulis, A. Yorgancioglu, T. Zuberbier, A. Bedbrook, W. Aberer, M. Adachi, A. Agusti, C. Akdis, M. Akdis, J. Ankri, A. Alonso, I. Annesi-Maesano, I. Ansotegui, J. Anto, S. Arnavielhe, H. Arshad, C. Bai, I. Baiardini, C. Bachert, A. Baigenzhin, C. Barbara, E. Bateman, B. Beghé, A. Kheder, K. Bennoor, M. Benson, K. Bergmann, T. Bieber, C. Bindslev-Jensen, L. Bjermer, H. Blain, F. Blasi, A. Boner, M. Bonini, S. Bonini, S. Bosnic-Anticevitch, L. Boulet, R. Bourret, P. Bousquet, F. Braido, A. Briggs, C. Brightling, J. Brozek, R. Buhl, P. Burney, A. Bush, F. Caballero-Fonseca, D. Caimmi, M. Calderon, P. Calverley, P. Camargos, G. Canonica, T. Camuzat, K. Carlsen, W. Carr, A. Carriazo, T. Casale, A. Cepeda Sarabia, L. Chatzi, Y. Chen, R. Chiron, E. Chkhartishvili, A. Chuchalin, K. Chung, G. Ciprandi, I. Cirule, L. Cox, D. Costa, A. Custovic, R. Dahl, S. Dahlen, U. Darsow, G. Carlo, F. Blay, T. Dedeu, D. Deleanu, E. Manuel Keenoy, P. Demoly, J. Denburg, P. Devillier, A. Didier, A. Dinh-Xuan, R. Djukanovic, D. Dokic, H. Douagui, G. Dray, R. Dubakiene, S. Durham, M. Dykewicz, Y. El-Gamal, R. Emuzyte, L. Fabbri, M. Fletcher, A. Fiocchi, A. Fink Wagner, J. Fonseca, W. Fokkens, F. Forastiere, P. Frith, M. Gaga, A. Gamkrelidze, J. Garces, J. Garcia-Aymerich, B. Gemicioğlu, J. Gereda, S. González Diaz, M. Gotua, I. Grisle, L. Grouse, Z. Gutter, M. Guzmán, L. Heaney, B. Hellquist-Dahl, D. Henderson, A. Hendry, J. Heinrich, D. Heve, F. Horak, J. Hourihane, P. Howarth, M. Humbert, M. Hyland, M. Illario, J. Ivancevich, J. Jardim, E. Jares, C. Jeandel, C. Jenkins, S. Johnston, O. Jonquet, K. Julge, K. Jung, J. Just, I. Kaidashev, M. Kaitov, O. Kalayci, A. Kalyoncu, T. Keil, P. Keith, L. Klimek, B. Koffi N’Goran, V. Kolek, G. Koppelman, M. Kowalski, I. Kull, P. Kuna, V. Kvedariene, B. Lambrecht, S. Lau, D. Larenas-Linnemann, D. Laune, L. Le, P. Lieberman, B. Lipworth, J. Li, K. Lodrup Carlsen, R. Louis, W. MacNee, Y. Magard, A. Magnan, B. Mahboub, A. Mair, I. Majer, M. Makela, P. Manning, S. Mara, G. Marshall, M. Masjedi, P. Matignon, M. Maurer, S. Mavale-Manuel, E. Melén, E. Melo-Gomes, E. Meltzer, A. Menzies-Gow, H. Merk, J. Michel, N. Miculinic, F. Mihaltan, B. Milenkovic, G. Mohammad, M. Molimard, I. Momas, A. Montilla-Santana, M. Morais-Almeida, M. Morgan, R. Mösges, J. Mullol, S. Nafti, L. Namazova-Baranova, R. Naclerio, A. Neou, H. Neffen, K. Nekam, B. Niggemann, G. Ninot, T. Nyembue, R. O’Hehir, K. Ohta, Y. Okamoto, K. Okubo, S. Ouedraogo, P. Paggiaro, I. Pali-Schöll, P. Panzner, N. Papadopoulos, A. Papi, H. Park, G. Passalacqua, I. Pavord, R. Pawankar, R. Pengelly, O. Pfaar, R. Picard, B. Pigearias, I. Pin, D. Plavec, D. Poethig, W. Pohl, T. Popov, F. Portejoie, P. Potter, D. Postma, D. Price, K. Rabe, F. Raciborski, F. Radier Pontal, S. Repka-Ramirez, S. Reitamo, S. Rennard, F. Rodenas, J. Roberts, J. Roca, L. Rodriguez Mañas, C. Rolland, M. Roman Rodriguez, A. Romano, J. Rosado-Pinto, N. Rosario, L. Rosenwasser, M. Rottem, D. Ryan, M. Sanchez-Borges, G. Scadding, H. Schunemann, E. Serrano, P. Schmid-Grendelmeier, H. Schulz, A. Sheikh, M. Shields, N. Siafakas, Y. Sibille, T. Similowski, F. Simons, J. Sisul, I. Skrindo, H. Smit, D. Solé, T. Sooronbaev, O. Spranger, R. Stelmach, P. Sterk, J. Sunyer, C. Thijs, T. To, A. Todo-Bom, M. Triggiani, R. Valenta, A. Valero, E. Valia, E. Valovirta, E. Ganse, M. Hage, O. Vandenplas, T. Vasankari, B. Vellas, J. Vestbo, G. Vezzani, P. Vichyanond, G. Viegi, C. Vogelmeier, T. Vontetsianos, M. Wagenmann, B. Wallaert, S. Walker, D. Wang, U. Wahn, M. Wickman, D. Williams, S. Williams, J. Wright, B. Yawn, P. Yiallouros, O. Yusuf, A. Zaidi, H. Zar, M. Zernotti, L. Zhang, N. Zhong, M. Zidarn, and J. Mercier

Abstract

Additional file 1. IPCRG scaling up activities.

Published
2016
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42. Light-Weighted Password-Based Multi-Group Authenticated Key Agreement for Wireless Sensor Networks.

Author

Chen, Mao-Sung, Chang, I-Pin, and Liu, Tung-Kuan

Subjects
WIRELESS sensor networks, QUANTUM cryptography, DIGITAL signatures, IMAGE encryption, PUBLIC key cryptography, ELLIPTIC curves, GROUP identity
Abstract

Security is a critical issue for medical and health care systems. Password-based group-authenticated key agreement for wireless sensor networks (WSNs) allows a group of sensor nodes to negotiate a common session key by using password authentication and to establish a secure channel by this session key. Many group key agreement protocols use the public key infrastructure, modular exponential computations on an elliptic curve to provide high security, and thus increase sensor nodes' overhead and require extra equipment for storing long-term secret keys. This work develops a novel group key agreement protocol using password authentication for WSNs, which is based on extended chaotic maps and does not require time-consuming modular exponential computations or scalar multiplications on an elliptic curve. Additionally, the proposed protocol is suitable for multiple independent groups and ensures that the real identities of group members cannot be revealed. The proposed protocol is not only more secure than related group key agreement protocols but also more efficient. [ABSTRACT FROM AUTHOR]

Published
2019
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43. Anaphylaxie alimentaire à la graine de courge

Author

C. Chatain, Marie-Thérèse Leccia, I. Pin, P. Pralong, and J.P. Jacquier

Subjects
Immunology and Allergy
Abstract

Introduction L’allergie alimentaire a la graine de courge est une allergie rarissime. Nous rapportons un cas pediatrique d’anaphylaxie a la graine de courge. Methodes Un garcon de 8 ans, aux ATCD d’asthme et d’allergies alimentaires gueries au lait de vache et a la noix de cajou et d’allergie persistante aux laits de brebis et de chevre, a presente une anaphylaxie de grade 3 apres la consommation de pain a la graine de tournesol et de courge. L’enfant consomme sans probleme les differentes cucurbitacees (differentes varietes de courge, courgette, concombre, melon et pasteque), l’arachide et tous les fruits a coque. Resultats Les prick-tests sont positifs aux graines des differentes especes de courge mais non a la chair. Ils sont douteux pour les autres graines comestibles, mais negatifs pour les huiles de pepin de courge, de lin, de sesame, les fruits a coque, l’arachide, pour le melon, le concombre, la pasteque, ainsi que pour les differentes farines. Les IgE specifiques sont positives a 3,75 KU/L pour la graine de citrouille, negatives pour la citrouille (chair) et pour les differentes graines. Un test de reintroduction aux graines de tournesol, de lin, de sesame et de pavot, propose du fait d’une faible sensibilisation cutanee a ces graines, est negatif a doses significatives. Discussion Utilisee en medecine traditionnelle depuis l’antiquite, la graine de courge a trouve une place de choix dans l’alimentation moderne avec l’avenement des regimes riches en acides gras polyinsatures. Mis a part des profilines et des proteines de 36, 48, 69, 77 et 87 kDa, les allergenes potentiels de la graine de courge pourraient correspondre a des albumines 2S et des globulines 7S ou 11S. Leur structure compacte, leur taille importante, leur abondance dans les graines et leur resistance a la denaturation thermique et a la digestion enzymatique seraient responsables de leurs proprietes allergeniques importantes. Conclusion L’utilisation croissante de la graine de courge dans l’alimentation moderne, liee aux effets therapeutiques potentiels de la graine de courge dans la prevention des maladies cardiovasculaires, des tumeurs et du vieillissement risque de conduire a une augmentation d’allergie alimentaire a la graine de courge.

Published
2017
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44. Exploring the association among the tryptophan to serotonin and kynurenine pathways, cognition and suicidal behaviour: a secondary analysis in a sample of individuals affected by Bipolar Disorder.

Author

P. Paribello, M. Manchia, A. Squassina, C. Pisanu, D. Congiu, S. Dall’Acqua, S. Sut, S. Nasini, M. Garzilli, B. Guiso, F. Suprani, V. Pulcinelli, M. N. Iaselli, I. Pinna, G. Somaini, L. Arru, C. Corrias, F. Pinna, S. Comai, and B. Carpiniello

Subjects
Psychiatry, RC435-571
Abstract

Introduction Stroop test iteration performances and metabolism of tryptophan (TRP) via serotonin (5-HT) and kynurenine (KYN) have both been associated with suicidal behaviors. This study aims to probe their possible interactions. Objectives We explored the association of the performances on the Emotion Inhibition Subtask (EIS) of the Brief Assessment of Cognition for Affective Disorder and the plasmatic levels of 5-hydroxytryptophan (5-HTP), 5-HT, KYN, melatonin (MLT) among subjects with Lifetime Suicidal Ideation (LSI) vs non-LSI, and with Lifetime Suicide Attempts (LSA) vs non-LSA. Methods Using R studio, we employed: 1) the t-test for parametric data and the Wilcoxon test for non-parametric data; 2) Linear Modeling to probe the associations of EIS performances with MLT, KYN, 5-HTP or 5-HT plasmatic levels. Results In a sample comprising 45 individuals affected by Bipolar Disorder, we found a statistically significant difference for the Color Naming (CN, image 1) and the Neutral words (NW) subtasks among LSA vs non-LSA. In LSI vs non-LSI, only the NW retained significance, but not the CN. A significant association emerged between CN and 5-HTP in LSI but not in non-LSI (image 2). Similarly, in LSA, an association was found between CN and 5-HTP, but not in non-LSA (image 3). No statistically significant difference emerged among groups regarding gender composition, age, pharmacological therapy, Body Mass Index, Hamilton Depression Rating Scale, Young Mania Rating Scale, or Clinical Global Impression scale - Severity. Image: Image 2: Image 3: Conclusions We found that the plasmatic levels of the metabolites of TRP via 5-HT were correlated to some EIS performances. These findings may represent a hypothesis-generating platform for further investigations. Disclosure of InterestNone Declared

Published
2023
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45. Resilience of people with a history of mental disorder during the COVID-19 pandemic: a 2-years longitudinal prospective study

Author

I. Pinucci, L. Tarsitani, F. Tedeschi, M. Patanè, R. Serra, D. Papola, C. Palantza, C. Acartürk, R. Bryant, S. Burchert, D. Fuhr, B. J. Hall, E. Mittendorfer-Rutz, N. Morina, C. Panter-Brick, S. Quero, S. Seedat, H. Setyowibowo, J. van der Waerden, M. Pasquini, M. Sijbrandij, and C. Barbui

Subjects
Psychiatry, RC435-571
Abstract

Introduction During the COVID-19 pandemic, people with mental disorders were exposed to a common and prolonged source of stress. Studies focusing on the consequences of the pandemic on individuals with a history of mental disorder are scarce, but they suggest a higher vulnerability as compared to the general population. Objectives We aimed at identifying predictors of stress resilience maintained over time among these people during the first two years of the pandemic. Methods The presented study is part of a larger 2-year, 5-wave international longitudinal online survey. The Patient Health Questionnaire, the Generalized Anxiety Disorder scale and the PTSD Checklist DSM-5 were used as latent class indicators for a proxy measure of distress. Specifically, a Latent-Class Analysis was performed to identify a group that showed resilient outcomes across all waves. We investigated socio-demographic characteristics, economic and housing status, lifestyle and habits, pandemic-related issues, and chronic disease. Adherence to and approval of the restrictions imposed, trust in governments and the scientific community during the pandemic were also assessed. Social support, fear of contamination and personal values were investigated respectively through the Oslo Social Support Scale, the Padua Inventory, and the Portrait Values Questionnaire. The aforementioned characteristics were used to predict sustained resilience through a logistic regression. Results A total of 1711 participants out of the total sample (8011 participants from 13 different countries) reported a diagnosis of mental disorder before the pandemic. Nine hundred forty-three participants completed at least three of the five versions of the survey and were included in the analysis. A latent class of participants with resilience maintained over time (sustained resilience) was identified, with an estimated probability of 24.8%. The demographic and clinical variables associated with a higher chance of sustained resilience were older age, maintaining a job during the pandemic, and having a larger number of people in the household. In contrast, female gender, losing job during the pandemic, having difficulty meeting basic needs, greater fear of contamination, a stronger focus on hedonism, less social support and feeling lonely resulted in a lower likelihood of being sustained resilient. Conclusions This study identified a number of factors that may help predict resilient outcomes maintained over time in people with mental disorders. COVID-19 related predictors of sustained resilience are new findings which might inform resilience-building interventions during pandemics. Disclosure of InterestNone Declared

Published
2023
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47. Improved calibration of rf cavities for relativistic electron beams: Effects of secondary corrections and experimental verification

Author

K. Shih, I. Petrushina, V. N. Litvinenko, I. Pinayev, J. Ma, G. Wang, Y. Jing, and Y. Wu

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

In the aspect of longitudinal beam bunching, the bunching strength can be controlled by the rf cavity phase and voltage. However, these machine parameters are different from those that interact with the beam itself. In order to gain control of the beam-cavity interaction, cavity calibration must be performed. Furthermore, it relies on fitting the beam energy gain versus cavity phase to a calibration function. Under the conventional assumption of relativistic beam conditions, the calibration function is a first harmonic sinusoidal function (a sinusoidal function with a period of 2π). However, this expression is insufficient for a high-voltage bunching cavity. Due to beam acceleration inside the cavity, an energy bias and a second harmonic function should be included to modify the conventional calibration function, even for a relativistic electron beam. In this paper, we will derive this modification and provide a comparison to both the Coherent Electron Cooling Experiment and the impact-t simulation, respectively.

Published
2023
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48. Accident anaphylactique sévère à l’arachide après test de réintroduction négatif

Author

J.P. Jacquier, Marie-Thérèse Leccia, C. Chatain, I. Pin, and P. Pralong

Subjects
Immunology and Allergy
Abstract

Introduction Le test de reintroduction alimentaire (TPO) represente l’etalon-or afin d’affirmer ou d’infirmer une allergie alimentaire. Nous rapportons ici un cas d’anaphylaxie a l’arachide survenue apres un TPO negatif. Methodes Une jeune fille de 6 ans et demi, aux antecedents d’eczema atopique actif, d’asthme et d’allergie alimentaire a l’œuf, a presente une reaction anaphylactique de grade 3, comprenant œdeme du visage, douleurs abdominales, vomissements, crise d’asthme et asthenie, immediatement apres avoir mange 2 M&M's (environ 800 mg d’arachide). Le prick-test a l’arachide etait positif a 13,5 mm, les IgE specifiques arachide et arah2 > 100 kU/L, confirmant le diagnostic d’hypersensibilite immediate a l’arachide. Cette reaction est survenue 18 mois apres un TPO a l’arachide negatif jusqu’a la dose cumulee de 10 g, qui avait ete propose en raison d’une faible sensibilisation avec un arah2 A noter que l’enfant n’avait jamais consomme d’arachide avant le TPO, ni entre le TPO et le choc anaphylactique, cette eviction complete ayant ete pratiquee dans un contexte d’allergie a l’arachide chez le frere. Discussion Il s’agit d’un cas rare d’anaphylaxie par sensibilisation a l’arachide survenue 18 mois apres un TPO negatif a des doses significatives. On peut s’interroger sur le role de l’eviction complete dans la rupture de tolerance et faire en complement l’hypothese que le TPO chez cette enfant faiblement sensibilisee a l’arachide ait pu induire la survenue d’allergie, d’autant qu’il s’agissait de la premiere ingestion de cet aliment. Plusieurs etudes font etat du role deletere d’un regime d’eviction au long cours dans la survenue de reactions allergiques parfois severes chez des patients sensibilises, mais asymptomatiques, alors que la consommation reguliere d’un aliment sensibilisant favoriserait sa tolerance. Conclusion A notre connaissance, il s’agit du premier cas publie d’allergie alimentaire possiblement induite par un TPO.

Published
2015
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49. Long lifetime of bialkali photocathodes operating in high gradient superconducting radio frequency gun

Author

E. Wang, V. N. Litvinenko, I. Pinayev, M. Gaowei, J. Skaritka, S. Belomestnykh, I. Ben-Zvi, J. C. Brutus, Y. Jing, J. Biswas, J. Ma, G. Narayan, I. Petrushina, O. Rahman, T. Xin, T. Rao, F. Severino, K. Shih, K. Smith, G. Wang, and Y. Wu

Subjects
Medicine, Science
Abstract

Abstract High brightness, high charge electron beams are critical for a number of advanced accelerator applications. The initial emittance of the electron beam, which is determined by the mean transverse energy (MTE) and laser spot size, is one of the most important parameters determining the beam quality. The bialkali photocathodes illuminated by a visible laser have the advantages of high quantum efficiency (QE) and low MTE. Furthermore, Superconducting Radio Frequency (SRF) guns can operate in the continuous wave (CW) mode at high accelerating gradients, e.g. with significant reduction of the laser spot size at the photocathode. Combining the bialkali photocathode with the SRF gun enables generation of high charge, high brightness, and possibly high average current electron beams. However, integrating the high QE semiconductor photocathode into the SRF guns has been challenging. In this article, we report on the development of bialkali photocathodes for successful operation in the SRF gun with months-long lifetime while delivering CW beams with nano-coulomb charge per bunch. This achievement opens a new era for high charge, high brightness CW electron beams.

Published
2021
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50. Treating Patients with Aripiprazol: A Safe Gamble?

Author

B. Leal, D. Vila-Chã, S. Garcia, I. Pinto, R. Mateiro, M. Avelino, M. Martins, and J. Salgado

Subjects
Gambling Disorder, Aripiprazol, Dopamine receptor, Psychiatry, RC435-571
Abstract

Introduction Aripiprazole (ARI) is an atypical antipsychotic drug with D2 partial agonist properties, usually prescribed to treat mood disorders (major depression or bipolar disorder) and schizophrenic disorder (schizophrenia or schizoaffective disorder). Dopamine receptor agonists, as is ARI, have been implicated in some cases of impulse-control problems, such as gambling disorder (GD), increased spending, hypersexuality and compulsive eating. Objectives Currently, it is hypothesized that aripiprazole may cause impulse-control problems because it can produce a hyperdopaminergic state in the mesolimbic pathway (reward system) through its predominant action on dopamine D3 receptors. We intend to do a non-systematic review of the scientific information regarding this subject. Methods The authors revised the published literature about this topic, selecting relevant articles, systematic reviews and case reports, with the topic words: “aripiprazol”, “gambling disorder” and “dopamine receptor” in scientific data base. Results Overall, a few cases of ARI-induced pathological gambling as well as ARI-induced hypersexuality have been reported. In one study it was verified that comorbid psychiatric and substance use disorders were common among those who have experienced GD or worsened GD after beginning ARI treatment. In another study, it was verified that the group of patients who reported this alleged side-effect were mostly young (mean age, 33.6 years), mostly men (88.2%) and most lived alone. Conclusions Attributing to dopamine agonists the only factor that can explain the onset of GD is simplistic and dangerous. Many other potential risk factors, including individual vulnerability factors (temperament, genetics) as well as environmental factors, must be considered. Disclosure No significant relationships.

Published
2022
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