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3. Prologue: Special Spotlight Issue on Japan

Author

Yano, Yuichiro, Nishiyama, Akira, Ishimitsu, Toshihiko, Kashihara, Naoki, Rakugi, Hiromi, Tamura, Kouichi, Itoh, Hiroshi, Tsuchihashi, Takuya, Sakima, Atsushi, Arima, Hisatomi, Matayoshi, Tetsutaro, Imai, Yutaka, Miura, Katsuyuki, Hisamatsu, Takashi, Asayama, Kei, Ohkubo, Takayoshi, Node, Kouihci, and Kario, Kazuomi

Published
2024
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10. Coronary Artery Calcium Progression Among the US and Japanese Men

Author

Hisamatsu, Takashi, Liu, Kiang, Chan, Cheeling, Krefman, Amy E, Fujiyoshi, Akira, Budoff, Matthew J, Miura, Katsuyuki, Lloyd-Jones, Donald M, and Ueshima, Hirotsugu

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Behavioral and Social Science, Clinical Research, Heart Disease - Coronary Heart Disease, Heart Disease, Atherosclerosis, Prevention, Cardiovascular, Black or African American, Aged, Asian, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Disease Progression, Health Status Disparities, Hispanic or Latino, Humans, Incidence, Japan, Longitudinal Studies, Male, Middle Aged, Prognosis, Prospective Studies, Racial Groups, Risk Assessment, Risk Factors, Severity of Illness Index, United States, Vascular Calcification, White People, coronary disease, ethnic groups, humans, risk factors, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Background The risk of coronary heart disease remains low in Japan, although distributions of several coronary risk factors have become comparable with those in the United States. We prospectively compared coronary atherosclerosis burden, measured with coronary artery calcium (CAC) progression, between men in the 2 countries. Methods In 2 population-based samples of 1712 US White, Black, Hispanic, Chinese men (baseline, 2000-2002) and 697 Japanese men in Japan (2006-2008) aged 45-74 years without clinical cardiovascular disease, we quantified CAC progression by serial computed tomography with medians of 3.4 and 5.2 years between scans, respectively. Results Among White, Black, Hispanic, Chinese, and Japanese men free of baseline CAC, CAC incidence was observed in 35.2%, 26.9%, 29.2%, 18.9%, and 29.2%, respectively. After adjustment for times between scans, demographics, behaviors, coronary risk factors, and their changes between scans, White men had significantly higher CAC incidence than Japanese men (relative risk, 1.68; 95% CI, 1.13-2.50). Among those with detectable baseline CAC, after similar adjustments, all the US race/ethnic groups had significantly greater annual changes in CAC score (mean [95% CI]: 39.4 [35.2-43.6] for White, 26.9 [21.4-32.4] for Black, 30.6 [24.7-36.5] for Hispanic, and 30.2 [22.6-37.8] for Chinese men) than Japanese men (15.9 [10.1-21.8]). Conclusions We found a higher CAC incidence among US White men and greater increases in existing CAC among all the US race/ethnic groups than among Japanese men in Japan. These differences persisted despite adjustment for differences in coronary risk factors.

Published
2019

12. Low-density lipoprotein particle profiles compared with standard lipids measurements in the association with asymptomatic intracranial artery stenosis

Author

Vu, Thien, primary, Yano, Yuichiro, additional, Pham, Huy Kien Tai, additional, Mondal, Rajib, additional, Ohashi, Mizuki, additional, Kitaoka, Kaori, additional, Moniruzzaman, Mohammad, additional, Torii, Sayuki, additional, Shiino, Akihiko, additional, Tsuji, Atsushi, additional, Hisamatsu, Takashi, additional, Okamura, Tomonori, additional, Kondo, Keiko, additional, Kadota, Aya, additional, Watanabe, Yoshiyuki, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2024
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15. Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men

Author

Horie, Minoru, Nakagawa, Yoshihisa, Yamamoto, Takashi, Nakano, Yasutaka, Ogawa, Emiko, Maegawa, Hiroshi, Morino, Katsutaro, Miyazawa, Itsuko, Watanabe, Yoshiyuki, Nozaki, Kazuhiko, Tooyama, Ikuo, Shiino, Akihiko, Andoh, Akira, Tsuru, Teruhiko, Ogita, Hisakazu, Miyamatsu, Naomi, Nakamura, Yasuyuki, Kadota, Aya, Kondo, Keiko, Torii, Sayuki, Kadowaki, Takashi, Kadowaki, Sayaka, Suzuki, Sentaro, Ito, Takahiro, Kunimura, Ayako, Segawa, Hiroyoshi, Fujiyoshi, Akira, Higashiyama, Aya, Okamura, Tomonori, Azuma, Koichiro, Sawamura, Tatsuya, Igase, Michiya, Tabara, Yasuharu, Sekikawa, Akira, Barinas-Mitchell, Emma J.M., Edmundowicz, Daniel, Ohkubo, Takayoshi, Hozawa, Atsushi, Murakami, Yoshitaka, Okuda, Nagako, Arima, Hisatomi, Satoh, Atsushi, Kita, Yoshikuni, Hisamatsu, Takashi, Yanagita, Masahiko, Abbott, Robert D., Ohno, Seiko, Takashima, Naoyuki, Miyagawa, Naoko, Zaid, Maryam, Saito, Yoshino, Syaifullah, Ali Haidar, Moniruzzaman, Mohammad, Waki, Takashi, Ueshima, Hirotsugu, and Miura, Katsuyuki

Published
2021
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19. Association of Anthropometric and CT-Based Obesity Indices with Subclinical Atherosclerosis

Author

Higo, Yosuke, primary, Hisamatsu, Takashi, additional, Nakagawa, Yoshihisa, additional, Sawayama, Yuichi, additional, Yano, Yuichiro, additional, Kadota, Aya, additional, Fujiyoshi, Akira, additional, Kadowaki, Sayaka, additional, Torii, Sayuki, additional, Kondo, Keiko, additional, Watanabe, Yoshiyuki, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2024
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29. Association of blood levels of marine omega-3 fatty acids with coronary calcification and calcium density in Japanese men

Author

Sekikawa, Akira, Mahajan, Hemant, Kadowaki, Sayaka, Hisamatsu, Takashi, Miyagawa, Naoko, Fujiyoshi, Akira, and Kadota, Aya

Subjects
Calcification (Physiology) -- Analysis, Atherosclerosis -- Development and progression -- Risk factors -- Analysis, Omega 3 fatty acids -- Analysis, Unsaturated fatty acids -- Analysis, Epidemiology -- Analysis, Medical schools -- Analysis, CAT scans, Clinical trials, Fatty acids, Tomography, Food/cooking/nutrition, Health
Abstract

Background/objectives: Clinical trials of eicosapentaenoic acid (EPA) among high-risk groups in Japan in which consumption of mairne-omega-3 fatty acids (OM3) is much higher than other countries showed slower progression of coronary atherosclerosis. We aimed to determine the cross-sectional associations of coronary artery calcification (CAC) and calcium density with OM3, EPA, and docosahexaenoic acid (DHA), two principal OM3, in the general population in Japan. Subjects/methods: The Shiga Epidemiological Study of Subclinical Atherosclerosis examined a population-based sample of 1074 men aged 40-79 in 2006-08 for computed tomography-measured CAC score (CCS), a well-established biomarker of coronary atherosclerosis, CAC density score (CDS), a potential marker of plaque stabilization, serum levels of OM3, and risk factors. Results: Prevalence of CCS > 0, [greater than or equal to] 100, and [greater than or equal to] 300 was 65.8%, 25.9%, and 12.9%, respectively; the mean (SD) OM3, EPA, and DHA were 10.1% (3.2), 3.2% (1.7), and 5.9% (1.6), respectively. Odds ratios (95% CI, p-value) of CCS 0, 100, and 300 in ordinal logistic regression associated with 1 SD increase of OM3, EPA, and DHA were 0.91 (0.81-1.03, p = 0.12), 0.99 (0.88-1.11, p = 0.87) and 0.84 (0.74-0.94, p = < 0.01), respectively. The inverse association of DHA with CCS remained significant in multivariate-adjusted model: odds ratio of 0.87 (0.77-0.99, p = 0.03). Blood levels of OM3, EPA, or DHA did not have any significant associations with CDS. Conclusions: DHA but not EPA had a significant inverse association with coronary atherosclerosis in the general population with high levels of OM3. Future trials are warranted comparing the effect of high-dose DHA and EPA on atherosclerosis and cardiovascular outcomes., Author(s): Akira Sekikawa [sup.1], Hemant Mahajan [sup.1], Sayaka Kadowaki [sup.2], Takashi Hisamatsu [sup.3], Naoko Miyagawa [sup.2], Akira Fujiyoshi [sup.2], Aya Kadota [sup.4], Hiroshi Maegawa [sup.5], Kiyoshi Murata [sup.6], Katsuyuki Miura [...]

Published
2019
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30. Relationship between Serum Irisin Levels and MRI-Measured Cerebral Small Vessel Disease in Japanese Men

Author

Moniruzzaman, Mohammad, primary, Kadota, Aya, additional, Hisamatsu, Takashi, additional, Segawa, Hiroyoshi, additional, Kondo, Keiko, additional, Torii, Sayuki, additional, Miyagawa, Naoko, additional, Fujiyoshi, Akira, additional, Yano, Yuichiro, additional, Watanabe, Yoshiyuki, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2023
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33. Lifetime cigarette smoking is associated with abdominal obesity in a community-based sample of Japanese men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Fujiyoshi, Akira, Miura, Katsuyuki, Kadowaki, Sayaka, Azuma, Koichiro, Tanaka, Sachiko, Hisamatsu, Takashi, Arima, Hisatomi, Kadota, Aya, Miyagawa, Naoko, Takashima, Naoyuki, Ohkubo, Takayoshi, Saitoh, Yoshino, Torii, Sayuki, Miyazawa, Itsuko, Maegawa, Hiroshi, Murata, Kiyoshi, and Ueshima, Hirotsugu

Published
2016
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34. Non-missense variants ofKCNH2show better outcomes in type 2 long QT syndrome

Author

Aizawa, Takanori, primary, Wada, Yuko, additional, Hasegawa, Kanae, additional, Huang, Hai, additional, Imamura, Tomohiko, additional, Gao, Jingshan, additional, Kashiwa, Asami, additional, Kohjitani, Hirohiko, additional, Fukuyama, Megumi, additional, Kato, Koichi, additional, Kato, Eri Toda, additional, Hisamatsu, Takashi, additional, Ohno, Seiko, additional, Makiyama, Takeru, additional, Kimura, Takeshi, additional, and Horie, Minoru, additional

Published
2023
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35. Non-missense variants of KCNH2 show better outcomes in type 2 long QT syndrome

Author

90823013, 30528302, Aizawa, Takanori, Wada, Yuko, Hasegawa, Kanae, Huang, Hai, Imamura, Tomohiko, Gao, Jingshan, Kashiwa, Asami, Kohjitani, Hirohiko, Fukuyama, Megumi, Kato, Koichi, Kato, Eri Toda, Hisamatsu, Takashi, Ohno, Seiko, Makiyama, Takeru, Kimura, Takeshi, Horie, Minoru, 90823013, 30528302, Aizawa, Takanori, Wada, Yuko, Hasegawa, Kanae, Huang, Hai, Imamura, Tomohiko, Gao, Jingshan, Kashiwa, Asami, Kohjitani, Hirohiko, Fukuyama, Megumi, Kato, Koichi, Kato, Eri Toda, Hisamatsu, Takashi, Ohno, Seiko, Makiyama, Takeru, Kimura, Takeshi, and Horie, Minoru

Abstract

AIMS: More than one-third of type 2 long QT syndrome (LQT2) patients carry KCNH2 non-missense variants that can result in haploinsufficiency (HI), leading to mechanistic loss-of-function. However, their clinical phenotypes have not been fully investigated. The remaining two-thirds of patients harbour missense variants, and past studies uncovered that most of these variants cause trafficking deficiency, resulting in different functional changes: either HI or dominant-negative (DN) effects. In this study, we examined the impact of altered molecular mechanisms on clinical outcomes in LQT2 patients. METHODS AND RESULTS: We included 429 LQT2 patients (234 probands) carrying a rare KCNH2 variant from our patient cohort undergoing genetic testing. Non-missense variants showed shorter corrected QT (QTc) and less arrhythmic events (AEs) than missense variants. We found that 40% of missense variants in this study were previously reported as HI or DN. Non-missense and HI-groups had similar phenotypes, while both exhibited shorter QTc and less AEs than the DN-group. Based on previous work, we predicted the functional change of the unreported variants-whether they cause HI or DN via altered functional domains-and stratified them as predicted HI (pHI)- or pDN-group. The pHI-group including non-missense variants exhibited milder phenotypes compared to the pDN-group. Multivariable Cox model showed that the functional change was an independent risk of AEs (P = 0.005). CONCLUSION: Stratification based on molecular biological studies enables us to better predict clinical outcomes in the patients with LQT2.

Published
2023

36. At-risk internet addiction and related factors among senior high school teachers in Japan based on a Nationwide survey

Author

Fukuda, Mari, Chowdhury, Mohammad, Chowdhury, Tanvir Turin, Tsumura, Hideki, Tsuchie, Rina, Kinuta, Minako, Hisamatsu, Takashi, Kanda, Hideyuki, Fukuda, Mari, Chowdhury, Mohammad, Chowdhury, Tanvir Turin, Tsumura, Hideki, Tsuchie, Rina, Kinuta, Minako, Hisamatsu, Takashi, and Kanda, Hideyuki

Abstract

Background: Internet addiction (IA) has been drawing attention to mental health. However, few reports have been found on the related factors of at-risk IA among regular workers by a nationwide survey. The study aimed to evaluate the characteristics of at-risk IA and identify related factors among senior high school teachers in Japan. Methods:This survey was a cross-sectional survey of high schools across Japan in 2017. There were 3189 teachers (2088 males and 1098 female) who participated in this survey. The questionnaire asked about their devices, both the time and the activities of using their internet, and sociodemographic factors. IA was measured by the internet addiction test (IAT) by which 40-79 points were classified as at-risk IA, and more as IA. We compared the related factors of at-risk IA and non-IA using descriptive analysis and multivariable regression analysis. Results: The rates of IA and at-risk IA were 0.09% (n = 3) and 6.91% (n = 220), respectively. At-risk IA was positively associated with activities on the internet for gaming, entertainment, net-surfing, and younger ages. In addition, the at-risk IA group had a longer time spent on the internet than the non-IA group. Conclusions: Around 7% of high school teachers are at-risk IA in this survey, though they have regular work. Our results suggest that at-risk IA may be reinforced not only by the active internet use such as gaming, but also by purposeless behaviors, such as net-surfing. Managing time on the internet may support preventing at-risk IA among senior high school teachers.

Published
2023

38. Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification

Author

Ueshima, Hirotsugu, Miura, Katsuyuki, Horie, Minoru, Nakano, Yasutaka, Yamamoto, Takashi, Ogawa, Emiko, Maegawa, Hiroshi, Miyazawa, Itsuko, Murata, Kiyoshi, Mitsunami, Kenichi, Nozaki, Kazuhiko, Shiino, Akihiko, Araki, Isao, Tsuru, Teruhiko, Toyama, Ikuo, Ogita, Hisakazu, Kurita, Souichi, Maeda, Toshinaga, Miyamatsu, Naomi, Kita, Toru, Kimura, Takeshi, Nishio, Yoshihiko, Nakamura, Yasuyuki, Okamura, Tomonori, Sekikawa, Akira, Barinas-Mitchell, Emma J.M., Edmundowicz, Daniel, Ohkubo, Takayoshi, Hozawa, Atsushi, Okuda, Nagako, Higashiyama, Aya, Nagasawa, Shinya, Kita, Yoshikuni, Murakami, Yoshitaka, Kadota, Aya, Fujiyoshi, Akira, Takashima, Naoyuki, Kadowaki, Takashi, Kadowaki, Sayaka, Abbott, Robert D., Ohno, Seiko, Arima, Hisatomi, Hisamatsu, Takashi, Miyagawa, Naoko, Torii, Sayuki, Saito, Yoshino, Zaid, Maryam, Suzuki, Sentaro, and Ito, Takahiro

Published
2016
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39. Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population

Author

Ueshima, Hirotsugu, Kadowaki, Takashi, Hisamatsu, Takashi, Fujiyoshi, Akira, Miura, Katsuyuki, Ohkubo, Takayoshi, Sekikawa, Akira, Kadota, Aya, Kadowaki, Sayaka, Nakamura, Yasuyuki, Miyagawa, Naoko, Okamura, Tomonori, Kita, Yoshikuni, Takashima, Naoyuki, Kashiwagi, Atsunori, Maegawa, Hiroshi, Horie, Minoru, Yamamoto, Takashi, Kimura, Takeshi, and Kita, Toru

Published
2016
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40. Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemiaLOX-1 ligand and IMT in Japanese

Author

Okamura, Tomonori, Miura, Katsuyuki, Sawamura, Tatsuya, Kadota, Aya, Hisamatsu, Takashi, Fujiyoshi, Akira, Miyamatsu, Naomi, Takashima, Naoyuki, Miyagawa, Naoko, Kadowaki, Takashi, Ohkubo, Takayoshi, Murakami, Yoshitaka, Nakamura, Yasuyuki, and Ueshima, Hirotsugu

Published
2016
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41. Ventricular Premature Complexes and Their Associated Factors in a General Population of Japanese Men

Author

AHMED, Sabrina, HISAMATSU, Takashi, KADOTA, Aya, FUJIYOSHI, Akira, SEGAWA, Hiroyoshi, TORII, Sayuki, TAKASHIMA, Naoyuki, KONDO, Keiko, NAKAGAWA, Yoshihisa, UESHIMA, Hirotsugu, MIURA, Katsuyuki, and Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group

Subjects
Male, Cholesterol, Cross-Sectional Studies, Japan, Hypertension, Humans, Cardiology and Cardiovascular Medicine, Lipids, Ventricular Premature Complexes
Abstract

Increased ventricular premature complexes (VPCs) are associated with a higher risk of cardiac morbidities. However, little information is available on the risk factors of Western general populations. Therefore, we aimed to assess the frequency and associated factors of VPCs in healthy general Japanese men. We conducted a population-based cross-sectional study in 517 men, aged 40 to 79 years, using 24-hour Holter electrocardiography. Age, body mass index, height, low-density lipoprotein cholesterol, triglycerides, high-density lipoprotein cholesterol, resting heart rate, diabetes mellitus, hypertension, physical activity, smoking, alcohol consumption, lipid-lowering therapy were included in multivariable negative binomial regression to assess independent correlates for the number of VPCs per hour. We observed at least 1 VPC in 1 hour in 429 men (83%). In multivariable negative binomial regression adjusted for all covariates simultaneously, age (risk ratio [95% confidence interval] 1.91 [1.56 to 2.33] per 1-SD increment), height (1.17 [1.04 to 1.49] per 1-SD increment), resting heart rate(1.34 [1.02 to 1.77] per 1-SD increment), diabetes mellitus (2.36 [1.17 to 4.76] ), hypertension (1.90 [1.03 to 3.50]), physical activity (0.67 [0.47 to 0.97] ), current smoking (4.23 [1.86 to 9.60] ), past smoking (2.08 [1.03 to 4.19] ), current light alcohol consumption (0.16 [0.04 to 0.64] ), and lipid-lowering therapy (0.47 [0.23 to 0.96] ) were independently associated with VPCs frequency. In conclusion, VPCs frequency was independently associated with age, height, resting heart rate, diabetes mellitus, hypertension, physical activity, smoking, alcohol consumption, and lipid-lowering therapy.

Published
2022

44. Abstract P671: Association Between Renal Function and Silent Cerebrovascular Disease in Japanese Men

Author

Miyagawa, Naoko, primary, Takashima, Naoyuki, additional, Kadota, Aya, additional, Fujiyoshi, Akira, additional, Torii, Sayuki, additional, Segawa, Hiroyoshi, additional, Miyazawa, Itsuko, additional, Kume, Shinji, additional, Kondo, Keiko, additional, Hisamatsu, Takashi, additional, Yano, Yuichiro, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2023
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45. PS-BPP01-4: THE RELATIONSHIP BETWEEN SERUM PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 CONCENTRATION AND THE PREVALENCE OF CORONARY ARTERY CALCIUM

Author

Kunimura, Ayako, primary, Miura, Katsuyuki, additional, Segawa, Hiroyoshi, additional, Torii, Sayuki, additional, Kondo, Keiko, additional, Hisamatsu, Takashi, additional, Yano, Yuichiro, additional, Kadota, Aya, additional, Fujiyoshi, Akira, additional, Nakagawa, Yoshihisa, additional, Okamura, Tomonori, additional, and Ueshima, Hirotsugu, additional

Published
2023
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46. Association and dose-response relationship between exposure to alcohol advertising media and current drinking: a nationwide cross-sectional study of Japanese adolescents

Author

Yoshida, Keita, primary, Kanda, Hideyuki, additional, Hisamatsu, Takashi, additional, Kuwabara, Yuki, additional, Kinjo, Aya, additional, Yoshimoto, Hisashi, additional, Ito, Teruna, additional, Kasuga, Hideaki, additional, Minobe, Ruriko, additional, Maesato, Hitoshi, additional, Jike, Maki, additional, Matsumoto, Yuuki, additional, Otsuka, Yuichiro, additional, Itani, Osamu, additional, Kaneita, Yoshitaka, additional, Higuchi, Susumu, additional, and Osaki, Yoneatsu, additional

Published
2023
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47. PS-BPP01-2: ASSOCIATIONS OF ARTERIAL STIFFNESS AND ATHEROSCLEROTIC BURDEN WITH BRAIN STRUCTURAL CHANGES AMONG JAPANESE MEN

Author

Azahar, Nazar Mohd, primary, Yano, Yuichiro, additional, Kadota, Aya, additional, Shiino, Akihiko, additional, Miyagawa, Naoko, additional, Kondo, Keiko, additional, Moniruzzaman, Mohammad, additional, Torii, Sayuki, additional, Segawa, Hiroyoshi, additional, Hisamatsu, Takashi, additional, Fujiyoshi, Akira, additional, Nozaki, Kazuhiko, additional, Tooyama, Ikuo, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2023
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48. PS-BPP01-3: DIFFERENTIAL ASSOCIATION OF CIRCULATING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 WITH THE SUBCLINICAL CEREBRAL SMALL VESSEL DISEASE AND INTRACRANIAL ARTERY STENOSIS

Author

Kunimura, Ayako, primary, Yano, Yuichiro, additional, Torii, Sayuki, additional, Kondo, Keiko, additional, Hisamatsu, Takashi, additional, Kadota, Aya, additional, Fujiyoshi, Akira, additional, Okamura, Tomonori, additional, Watanabe, Yoshiyuki, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2023
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