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11. Rationale and design of the pullback pressure gradient (PPG) global registry

Author

Munhoz, Daniel, Collet, Carlos, Mizukami, Takuya, Yong, Andy, Leone, Antonio Maria, Eftekhari, Ashkan, Ko, Brian, da Costa, Bruno R., Berry, Colin, Collison, Damien, Perera, Divaka, Christiansen, Evald Høj, Rivero, Fernando, Zimmermann, Frederik M., Ando, Hirohiko, Matsuo, Hitoshi, Nakayama, Masafumi, Escaned, Javier, Sonck, Jeroen, Sakai, Koshiro, Adjedj, Julien, Desta, Liyew, van Nunen, Lokien X., West, Nick E.J., Fournier, Stephane, Storozhenko, Tatyana, Amano, Tetsuya, Engstrøm, Thomas, Johnson, Thomas, Shinke, Toshiro, Biscaglia, Simone, Fearon, William F., Ali, Ziad, De Bruyne, Bernard, and Johnson, Nils P.

Published
2023
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12. Impact of Post-PCI FFR Stratified by Coronary Artery

Author

Collet, Carlos, Johnson, Nils P., Mizukami, Takuya, Fearon, William F., Berry, Colin, Sonck, Jeroen, Collison, Damien, Koo, Bon-Kwon, Meneveau, Nicolas, Agarwal, Shiv Kumar, Uretsky, Barry, Hakeem, Abdul, Doh, Joon-Hyung, Da Costa, Bruno R., Oldroyd, Keith G., Leipsic, Jonathon A., Morbiducci, Umberto, Taylor, Charles, Ko, Brian, Tonino, Pim A.L., Perera, Divaka, Shinke, Toshiro, Chiastra, Claudio, Sposito, Andrei C., Leone, Antonio Maria, Muller, Olivier, Fournier, Stephane, Matsuo, Hitoshi, Adjedj, Julien, Amabile, Nicolas, Piróth, Zsolt, Alfonso, Fernando, Rivero, Fernando, Ahn, Jung-Min, Toth, Gabor G., Ihdayhid, Abdul, West, Nick E.J., Amano, Tetsuya, Wyffels, Eric, Munhoz, Daniel, Belmonte, Marta, Ohashi, Hirofumi, Sakai, Koshiro, Gallinoro, Emanuele, Barbato, Emanuele, Engstrøm, Thomas, Escaned, Javier, Ali, Ziad A., Kern, Morton J., Pijls, Nico H.J., Jüni, Peter, and De Bruyne, Bernard

Published
2023
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17. Artificial Intelligence, Virtual Reality, and the Metaverse in Cardiovascular Imaging: Tools for Transformation or Technological Overreach?

Author

Skalidis, Ioannis, Tzimas, Georgios, Antiochos, Panagiotis, Suc, Gaspard, Lu, Henri, Salihu, Adil, Fournier, Stephane, Muller, Olivier, Maurizi, Niccolo', and Arangalage, Dimitri

Subjects
CARDIOVASCULAR disease diagnosis, COMPUTER simulation, DIAGNOSTIC imaging, MEDICAL education, ARTIFICIAL intelligence, VIRTUAL reality, DEEP learning, MACHINE learning, ACCURACY, AUTOMATION, USER interfaces, ALGORITHMS
Abstract

The article focuses on the potential impact of emerging technologies like artificial intelligence, virtual reality, and the metaverse on cardiovascular imaging. Topics include the role of artificial intelligence in enhancing diagnostic accuracy and workflow, the limited practical applications of virtual reality in clinical practice, and the challenges facing the metaverse in transforming patient care and clinician collaboration.

Published
2024
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18. Risk of myocardial infarction based on endothelial shear stress analysis using coronary angiography

Author

Candreva, Alessandro, Pagnoni, Mattia, Rizzini, Maurizio Lodi, Mizukami, Takuya, Gallinoro, Emanuele, Mazzi, Valentina, Gallo, Diego, Meier, David, Shinke, Toshiro, Aben, Jean-Paul, Nagumo, Sakura, Sonck, Jeroen, Munhoz, Daniel, Fournier, Stephane, Barbato, Emanuele, Heggermont, Ward, Cook, Stephane, Chiastra, Claudio, Morbiducci, Umberto, De Bruyne, Bernard, Muller, Oliver, and Collet, Carlos

Published
2022
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19. Influence of Pathophysiological Patterns of Coronary Artery Disease on Immediate Percutaneous Coronary Intervention Outcomes

Author

Collet, Carlos, primary, Munhoz, Daniel, additional, Mizukami, Takuya, additional, Sonck, Jeroen, additional, Matsuo, Hitoshi, additional, Shinke, Toshiro, additional, Ando, Hirohiko, additional, Ko, Brian, additional, Biscaglia, Simone, additional, Rivero, Fernando, additional, Engstrøm, Thomas, additional, Arslani, Ketina, additional, Leone, Antonio Maria, additional, van Nunen, Lokien X., additional, Fearon, William F., additional, Christiansen, Evald Høj, additional, Fournier, Stephane, additional, Desta, Liyew, additional, Yong, Andy, additional, Adjej, Julien, additional, Escaned, Javier, additional, Nakayama, Masafumi, additional, Eftekhari, Ashkan, additional, Zimmermann, Frederik M., additional, Sakai, Koshiro, additional, Storozhenko, Tatyana, additional, da Costa, Bruno R., additional, Campo, Gianluca, additional, West, Nick E.J., additional, De Potter, Tom, additional, Heggermont, Ward, additional, Buytaert, Dimitri, additional, Bartunek, Jozef, additional, Berry, Colin, additional, Collison, Damien, additional, Johnson, Thomas, additional, Amano, Tetsuya, additional, Perera, Divaka, additional, Jeremias, Allen, additional, Ali, Ziad, additional, Pijls, Nico H.J., additional, De Bruyne, Bernard, additional, and Johnson, Nils P., additional

Published
2024
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20. A study of ChatGPT in facilitating Heart Team decisions on severe aortic stenosis

Author

Salihu, Adil, primary, Meier, David, additional, Noirclerc, Nathalie, additional, Skalidis, Ioannis, additional, Mauler-Wittwer, Sarah, additional, Recordon, Frederique, additional, Kirsch, Matthias, additional, Roguelov, Christan, additional, Berger, Alexandre, additional, Sun, Xiaowu, additional, Abbe, Emmanuel, additional, Marcucci, Carlo, additional, Rancati, Valentina, additional, Rosner, Lorenzo, additional, Scala, Emanuelle, additional, Rotzinger, David C., additional, Humbert, Marc, additional, Muller, Olivier, additional, Lu, Henri, additional, and Fournier, Stephane, additional

Published
2024
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21. Microvascular Resistance Reserve for Assessment of Coronary Microvascular Function: JACC Technology Corner

Author

De Bruyne, Bernard, Pijls, Nico H.J., Gallinoro, Emanuele, Candreva, Alessandro, Fournier, Stephane, Keulards, Danielle C.J., Sonck, Jeroen, van’t Veer, Marcel, Barbato, Emanuele, Bartunek, Jozef, Vanderheyden, Marc, Wyffels, Eric, De Vos, Annemiek, El Farissi, Mohamed, Tonino, Pim A.L., Muller, Olivier, Collet, Carlos, and Fearon, William F.

Published
2021
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24. Basics of Coronary Thermodilution

Author

Candreva, Alessandro, Gallinoro, Emanuele, van ’t Veer, Marcel, Sonck, Jeroen, Collet, Carlos, Di Gioia, Giuseppe, Kodeboina, Monika, Mizukami, Takuya, Nagumo, Sakura, Keulards, Danielle, Fournier, Stephane, Pijls, Nico H.J., and De Bruyne, Bernard

Published
2021
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25. Influence of Pathophysiological Patterns of Coronary Artery Disease on Immediate Percutaneous Coronary Intervention Outcomes

Author

Collet, Carlo, Munhoz, Daniel, Mizukami, Takuya, Sonck, Jeroen, Matsuo, Hitoshi, Shinke, Toshiro, Ando, Hirohiko, Ko, Brian, Biscaglia, Simone, Rivero, Fernando, Engstrøm, Thoma, Arslani, Ketina, Leone, Antonio Maria, van Nunen, Lokien X, Fearon, William F, Christiansen, Evald Høj, Fournier, Stephane, Desta, Liyew, Yong, Andy, Adjej, Julien, Escaned, Javier, Nakayama, Masafumi, Eftekhari, Ashkan, Zimmermann, Frederik M, Sakai, Koshiro, Storozhenko, Tatyana, da Costa, Bruno R, Campo, Gianluca, West, Nick E J, De Potter, Tom, Heggermont, Ward, Buytaert, Dimitri, Bartunek, Jozef, Berry, Colin, Collison, Damien, Johnson, Thoma, Amano, Tetsuya, Perera, Divaka, Jeremias, Allen, Ali, Ziad, Pijls, Nico H J, De Bruyne, Bernard, Johnson, Nils P, Leone, Antonio Maria (ORCID:0000-0002-1276-9883), Collet, Carlo, Munhoz, Daniel, Mizukami, Takuya, Sonck, Jeroen, Matsuo, Hitoshi, Shinke, Toshiro, Ando, Hirohiko, Ko, Brian, Biscaglia, Simone, Rivero, Fernando, Engstrøm, Thoma, Arslani, Ketina, Leone, Antonio Maria, van Nunen, Lokien X, Fearon, William F, Christiansen, Evald Høj, Fournier, Stephane, Desta, Liyew, Yong, Andy, Adjej, Julien, Escaned, Javier, Nakayama, Masafumi, Eftekhari, Ashkan, Zimmermann, Frederik M, Sakai, Koshiro, Storozhenko, Tatyana, da Costa, Bruno R, Campo, Gianluca, West, Nick E J, De Potter, Tom, Heggermont, Ward, Buytaert, Dimitri, Bartunek, Jozef, Berry, Colin, Collison, Damien, Johnson, Thoma, Amano, Tetsuya, Perera, Divaka, Jeremias, Allen, Ali, Ziad, Pijls, Nico H J, De Bruyne, Bernard, Johnson, Nils P, and Leone, Antonio Maria (ORCID:0000-0002-1276-9883)

Abstract

Background: Diffuse coronary artery disease (CAD) impacts the safety and efficacy of percutaneous coronary intervention (PCI). Pathophysiological CAD patterns can be quantified using fractional flow reserve (FFR) pullbacks incorporating the pullback pressure gradient (PPG) calculation. This study aimed to establish the capacity of PPG to predict optimal revascularisation and procedural outcomes. Methods: This prospective, investigator-initiated, single-arm, multicentre study enrolled patients with at least one epicardial lesion with an FFR ≤ 0.80 scheduled for PCI. Manual FFR pullbacks were employed to calculate PPG. The primary outcome of optimal revascularisation was defined as a post-PCI FFR ≥ 0.88. Results: 993 patients with 1044 vessels were included. The mean FFR was 0.68 ± 0.12, PPG 0.62 ± 0.17, and post-PCI FFR 0.87 ± 0.07. PPG was significantly correlated with the change in FFR after PCI (r=0.65, 95% CI 0.61-0.69, p<0.001) and demonstrated excellent predicted capacity for optimal revascularisation (AUC 0.82, 95% CI 0.79-0.84, p<0.001). Conversely, FFR alone did not predict revascularisation outcomes (AUC 0.54, 95% CI 0.50-0.57). PPG influenced treatment decisions in 14% of patients, redirecting them from PCI to alternative treatment modalities. Periprocedural myocardial infarction occurred more frequently in patients with low PPG (<0.62) compared to those with focal disease (OR 1.71, 95% CI: 1.00-2.97). Conclusions: Pathophysiological CAD patterns distinctly affect the safety and effectiveness of PCI. The PPG showed an excellent predictive capacity for optimal revascularisation and demonstrated added value compared to a FFR measurement.

Published
2024

27. Measuring Absolute Coronary Flow and Microvascular Resistance by Thermodilution

Author

Belmonte, Marta, primary, Gallinoro, Emanuele, additional, Pijls, Nico H.J., additional, Bertolone, Dario Tino, additional, Keulards, Danielle C.J., additional, Viscusi, Michele Mattia, additional, Storozhenko, Tatyana, additional, Mizukami, Takuya, additional, Mahendiran, Thabo, additional, Seki, Ruiko, additional, Fournier, Stephane, additional, de Vos, Annemiek, additional, Adjedj, Julien, additional, Barbato, Emanuele, additional, Sonck, Jeroen, additional, Damman, Peter, additional, Keeble, Thomas, additional, Fawaz, Samer, additional, Gutiérrez-Barrios, Alejandro, additional, Paradies, Valeria, additional, Bouisset, Frederic, additional, Kern, Morton J., additional, Fearon, William F., additional, Collet, Carlos, additional, and De Bruyne, Bernard, additional

Published
2024
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28. Transcaval versus Supra-Aortic Vascular Accesses for Transcatheter Aortic Valve Replacement: A Systematic Review with Meta-Analysis

Author

Antiochos, Panagiotis, primary, Kirsch, Matthias, additional, Monney, Pierre, additional, Tzimas, Georgios, additional, Meier, David, additional, Fournier, Stephane, additional, Ferlay, Clémence, additional, Nowacka, Anna, additional, Rancati, Valentina, additional, Abellan, Christophe, additional, Skalidis, Ioannis, additional, Muller, Olivier, additional, and Lu, Henri, additional

Published
2024
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30. Cardiologie: ce qui a changé en 2023

Author

Salihu, Adil, primary, Meier, David, additional, Kilani, Nadia, additional, Burdet, Odile, additional, Tzimas, Georgios, additional, Antiochos, Panagiotis, additional, Masi, Ambra, additional, Teres, Cheryl, additional, Ascione, Ciro, additional, Rosset, Sabina, additional, Daux, Aurélien, additional, Domenichini, Giulia, additional, Ladouceur, Magalie, additional, Yerly, Patrick, additional, Schwitter, Juerg, additional, Monney, Pierre, additional, Rutz, Tobias, additional, Bouchardy, Judith, additional, Pruvot, Etienne, additional, Muller, Olivier, additional, and Fournier, Stephane, additional

Published
2024
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33. Energy Loss Index and Dimensionless Index Outperform Direct Valve Planimetry in Low-Gradient Aortic Stenosis.

Author

Hugelshofer, Sarah, de Brito, Diana, Antiochos, Panagiotis, Tzimas, Georgios, Rotzinger, David C., Auberson, Denise, Vella, Agnese, Fournier, Stephane, Kirsch, Matthias, Muller, Olivier, and Monney, Pierre

Subjects
AORTIC stenosis, ENERGY dissipation, TRANSESOPHAGEAL echocardiography, VALVES, RECEIVER operating characteristic curves
Abstract

Background/Objectives: Among patients with suspected severe aortic stenosis (AS), discordance between effective orifice area (EOA) and transvalvular gradients is frequent and requires a multiparametric workup including flow assessment and calcium-scoring to confirm true severe AS. The aim of this study was to assess direct planimetry, energy loss index (Eli) and dimensionless index (DI) as stand-alone parameters to identify non-severe AS in discordant cases. Methods: In this prospective cohort study, we included consecutive AS patients > 70 years with EOA < 1.0 cm2 referred for valve replacement between 2014 and 2017. AS severity was retrospectively reassessed using the multiparametric work-up recommended in the 2021 ESC/EACTS guidelines. DI and ELi were calculated, and valve area was measured by direct planimetry on transesophageal echocardiography. Results: A total of 101 patients (mean age 82 y; 57% male) were included. Discordance between EOA and gradients was observed in 46% and non-severe AS found in 24% despite an EOA < 1 cm2. Valve planimetry performed poorly, with an area under the ROC curve (AUC) of 0.64. At a cut-off value of >0.82 cm2, sensitivity and specificity to identify non-severe AS were 67 and 66%, respectively. DI and ELi showed a higher diagnostic accuracy, with an AUC of 0.77 and 0.76, respectively. Cut-off values of >0.24 and >0.6 cm2/m2 identified non-severe AS, with a high specificity of 79% and 91%, respectively. Conclusions: Almost one in four patients with EOA < 1 cm2 had non-severe AS according to guideline-recommended multiparametric assessment. Direct valve planimetry revealed poor diagnostic accuracy and should be interpreted with caution. Usual prognostic cut-off values for DI > 0.24 and ELI > 0.6 cm2/m2 identified non-severe AS with high specificity and should therefore be included in the assessment of low-gradient AS. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Metaverse-based cardiac magnetic resonance imaging simulation application for overcoming claustrophobia: a preliminary feasibility trial.

Author

Skalidis, Ioannis, Arangalage, Dimitri, Kachrimanidis, Ioannis, Antiochos, Panagiotis, Tsioufis, Konstantinos, Fournier, Stephane, Skalidis, Emmanouil, Olivotto, Iacopo, and Maurizi, Niccolo

Abstract

Introduction: Cardiac magnetic resonance imaging (CMR) is vital, but claustrophobia affects 10% of patients. The metaverse, an immersive virtual and augmented reality environment, has healthcare potential. We present a metaverse-based CMR simulation for claustrophobic patients. Methods: Three cardiomyopathy patients, initially CMR-refusing due to claustrophobia, received training via a virtual reality headset in a metaverse-based virtual hospital. Training efficacy was assessed through questionnaires and anxiety scales. Results: The patients successfully completed metaverse-based training, adapting to the CMR simulation. On CMR day, all entered the machine without issues and with reduced anxiety. Patients found the training useful, suggesting platform familiarization. Discussion: Our study demonstrates the metaverse's potential in alleviating CMR-related claustrophobia. The immersive nature enhances patient preparation, although usability improvements are needed. Further research should compare this approach with alternatives. Cardiac magnetic resonance imaging (CMR) is a vital tool for diagnosing heart problems, but some patients cannot undergo it due to claustrophobia. To address this, researchers are exploring new methods like hypnosis and simulations. One emerging technology, the metaverse, a 3D virtual reality (VR) environment, is being tested in healthcare. This study created a metaverse-based simulation to help claustrophobic patients prepare for CMR. Three patients with heart issues were given VR headsets to access a virtual hospital in the metaverse. Inside, they were trained for CMR step by step, experiencing the process and sounds realistically. Training was done 1 week, 3 days, and 1 day before the real CMR. Anxiety levels were measured. All patients completed the virtual training without issues. During the first simulations, some could not complete entering the virtual CMR machine due to anxiety. However, by the final simulation, all succeeded. On CMR day, all completed the scan without problems, and their anxiety levels decreased significantly from the initial training. Patients found the training helpful, but the platform's usability needed improvement. The study demonstrates that metaverse-based simulations can help patients overcome claustrophobia to successfully undergo CMR. This technology holds promise for simulating medical situations, easing patient fears, and improving preparation. However, further work is needed to make it user-friendly and accessible without assistance. This study encourages more research to assess the usefulness of the metaverse for broader patient groups, comparing it with other methods like hypnosis or sedation. Metaverse VR eases CMR claustrophobia! Tech innovation reduces anxiety and boosts scan success. Exciting clinical support tool. More research ahead! #HealthTech #Innovation Article highlights Metaverse-based cardiac magnetic resonance imaging simulation The study explored using a metaverse-based simulation to help claustrophobic patients with cardiac magnetic resonance imaging (CMR). Virtual reality headsets and a metaverse hospital were used to simulate the CMR process, aiming to assess its feasibility, efficacy, and usability. Positive patient response Three patients with claustrophobia underwent metaverse-based CMR simulation before the actual exam. All patients completed simulations successfully, and on the exam day, they completed CMR without issues. Patients reported reduced anxiety, indicating the potential benefits of the approach. Potential of metaverse technology The study demonstrates how metaverse simulations can alleviate anxiety and improve patient readiness for CMR scans. While the simulation shows promise, further refinement of user-friendliness is needed. The technology's applicability across diverse patient groups compared with alternative methods warrants future investigation. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Head-to-head comparison of two angiography-derived fractional flow reserve techniques in patients with high-risk acute coronary syndrome: A multicenter prospective study

Author

Skalidis, Ioannis, primary, Noirclerc, Nathalie, additional, Meier, David, additional, Luangphiphat, Wongsakorn, additional, Cagnina, Aurelien, additional, Mauler-Wittwer, Sarah, additional, Mahendiran, Thabo, additional, De Bruyne, Bernard, additional, Candreva, Alessandro, additional, Collet, Carlos, additional, Sonck, Jeroen, additional, Muller, Olivier, additional, and Fournier, Stephane, additional

Published
2023
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37. Transcatheter interventions for left-sided valvular heart disease complicated by cardiogenic shock: a consensus statement from the European Association of Percutaneous Cardiovascular Interventions (EAPCI) in collaboration with the Association for Acute Cardiovascular&nbsp;Care (ACVC) and the ESC Working Group on Cardiovascular Surgery

Author

Fraccaro, Chiara, primary, Karam, Nicole, additional, Möllmann, Helge, additional, Bleiziffer, Sabine, additional, Bonaros, Nikolaos, additional, Teles, Rui Campante, additional, Carrilho Ferreira, Pedro, additional, Chieffo, Alaide, additional, Czerny, Martin, additional, Donal, Erwan, additional, Dudek, Dariusz, additional, Dumonteil, Nicolas, additional, Esposito, Giovanni, additional, Fournier, Stephane, additional, Hassager, Christian, additional, Kim, Won-Keun, additional, Krychtiuk, Konstantin A., additional, Mehilli, Julinda, additional, Pręgowski, Jerzy, additional, Stefanini, Giulio G., additional, Ternacle, Julien, additional, Thiele, Holger, additional, Thielmann, Matthias, additional, Vincent, Flavien, additional, von Bardeleben, Ralph Stephan, additional, and Tarantini, Giuseppe, additional

Published
2023
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39. Management of coronary artery disease in patients undergoing transcatheter aortic valve implantation. A clinical consensus statement from the European Association of Percutaneous Cardiovascular Interventions in collaboration with the ESC Working Group on Cardiovascular Surgery

Author

Tarantini, Giuseppe, Tang, Gilbert, Nai Fovino, Luca, Blackman, Daniel, Van Mieghem, Nicolas M., Kim, Won-Keun, Karam, Nicole, Carrilho-Ferreira, Pedro, Fournier, Stephane, Pręgowski, Jerzy, Fraccaro, Chiara, Vincent, Flavien, Campante Teles, Rui, Mylotte, Darren, Wong, Ivan, Bieliauskas, Gintautas, Czerny, Martin, Bonaros, Nikolaos, Parolari, Alessandro, Dudek, Darius, Tchetche, Didier, Eltchaninoff, Hélène, de Backer, Ole, Stefanini, Giulio, Sondergaard, Lars, Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Cardiology, Cardiothoracic Surgery, and Repositório da Universidade de Lisboa

Subjects
TAVI, Coronary arterydisease, SDG 3 - Good Health and Well-being, Aortic stenosis, Cardiology and Cardiovascular Medicine
Abstract

© Europa Digital & Publishing 2023. All rights reserved, Significant coronary artery disease (CAD) is a frequent finding in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI), and the management of these two conditions becomes of particular importance with the extension of the procedure to younger and lower-risk patients. Yet, the preprocedural diagnostic evaluation and the indications for treatment of significant CAD in TAVI candidates remain a matter of debate. In this clinical consensus statement, a group of experts from the European Association of Percutaneous Cardiovascular Interventions (EAPCI) in collaboration with the European Society of Cardiology (ESC) Working Group on Cardiovascular Surgery aims to review the available evidence on the topic and proposes a rationale for the diagnostic evaluation and indications for percutaneous revascularisation of CAD in patients with severe aortic stenosis undergoing transcatheter treatment. Moreover, it also focuses on commissural alignment of transcatheter heart valves and coronary re-access after TAVI and redo-TAVI.

Published
2023

41. High Coronary Shear Stress in Patients With Coronary Artery Disease Predicts Myocardial Infarction

Author

Kumar, Arnav, Thompson, Elizabeth W., Lefieux, Adrien, Molony, David S., Davis, Emily L., Chand, Nikita, Fournier, Stephane, Lee, Hee Su, Suh, Jon, Sato, Kimi, Ko, Yi-An, Molloy, Daniel, Chandran, Karthic, Hosseini, Hossein, Gupta, Sonu, Milkas, Anastasios, Gogas, Bill, Chang, Hyuk-Jae, Min, James K., Fearon, William F., Veneziani, Alessandro, Giddens, Don P., King, Spencer B., III, De Bruyne, Bernard, and Samady, Habib

Published
2018
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42. Prognostic value of pulse pressure after an acute coronary syndrome

Author

Harbaoui, Brahim, Nanchen, David, Lantelme, Pierre, Gencer, Baris, Heg, Dick, Klingenberg, Roland, Räber, Lorenz, Carballo, David, Matter, Christian M., Windecker, Stephan, Mach, François, Rodondi, Nicolas, Eeckhout, Eric, Monney, Pierre, Antiochos, Panagiotis, Schwitter, Juerg, Pascale, Patrizio, Fournier, Stephane, Courand, Pierre-Yves, Lüscher, Thomas F., and Muller, Olivier

Published
2018
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47. Relationship between Pro-Inflammatory Cytokines and Gut Microbiome in Chronic Coronary Syndrome Patients Undergoing Coronary Angiography: A Cross-Sectional Study.

Author

Luangphiphat, Wongsakorn, Prombutara, Pinidphon, Eeckhout, Eric, Fournier, Stephane, Pradidarcheep, Wisuit, and Taweechotipatr, Malai

Abstract

Background: Chronic coronary syndrome (CCS) patients have a high mortality rate globally. Atherosclerosis, a cause of CCS, is influenced by inflammation. Pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) have a key role in the process of atherosclerosis. Moreover, gut microbiota dysbiosis can lead to leaky gut syndrome, subsequently triggering abnormal immune responses and contributing to diseases, including atherosclerosis and coronary artery disease (CAD). Objective: To study the relationship between pro-inflammatory cytokines and gut microbiome in CCS patients undergoing coronary angiography. Material and Methods: Participants were divided into two groups by using statistical matching techniques with age and gender, as CCS patients and healthy participants. Each patient's blood was collected on the day of the appointment. All patients' feces were collected one day before an appointment. The present research was a cross-sectional study. Results: Fifty-three patients, including 28 CCS patients and 25 healthy participants were enrolled. CCS patients had a higher level of TNF-α compared to healthy participants with statistical significance at 79.31 pg/mL. Phascolarctobacterium, Sutterella, and Prevotella could distinguish CCS patients from healthy participants based on receiver operating characteristic (ROC) analysis. Proteus and Phascolarctobacterium were positively correlated with TNF-α. Conclusion: There is a potential relationship between gut microbiome composition and inflammatory biomarkers in CCS patients. Pro-inflammatory cytokines and specific bacterial genera may be related to indicate significant CAD in CCS patients undergoing coronary angiography. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Abstract 15491: Effects of Intensive Smoking Cessation Counseling After Acute Coronary Syndrome on 5-year Incidence of Major Adverse Cardiovascular Events and Smoking Abstinence

Author

Gilgien Denereaz, Lauriane, Auer, Reto, Gencer, Baris, Carballo, David, Raeber, Lorenz, Klingenberg, Roland, Matter, Christian M, Sudano, Isabella, Luescher, Thomas F, Windecker, Stephan, Muller, Olivier, Fournier, Stephane, Rodondi, Nicolas, Mach, Francois, and Nanchen, David

Published
2020
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50. Circadian dependence of manual thrombus aspiration benefit in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Author

Fournier, Stephane, Muller, Olivier, Benedetto, Umberto, Roffi, Marco, Pilgrim, Thomas, Eberli, Franz R., Rickli, Hans, Radovanovic, Dragana, Erne, Paul, Cook, Stéphane, Noble, Stéphane, Fesselet, Rachel, Zuffi, Andrea, Degrauwe, Sophie, Masci, PierGiorgio, Windecker, Stephan, Eeckhout, Eric, Iglesias, Juan F., and on behalf on the AMIS Plus Investigators

Published
2018
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