161 results on '"Dongdong Su"'
Search Results
2. A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF
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Cao Lu, Cong Meng, Yuying Li, Jinling Yuan, Xiaojun Ren, Liang Gao, Dongdong Su, Kai Cao, Mengchao Cui, Qing Yuan, and Xueyun Gao
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Science - Abstract
Abstract To date, earlier diagnosis of Alzheimer’s disease (AD) is still challenging. Recent studies revealed the elevated expression of connective tissue growth factor (CTGF) in AD brain is an upstream regulator of amyloid-beta (Aβ) plaque, thus CTGF could be an earlier diagnostic biomarker of AD than Aβ plaque. Herein, we develop a peptide-coated gold nanocluster that specifically targets CTGF with high affinity (KD ~ 21.9 nM). The probe can well penetrate the blood-brain-barrier (BBB) of APP/PS1 transgenic mice at early-stage (earlier than 3-month-old) in vivo, allowing non-invasive NIR-II imaging of CTGF when there is no appearance of Aβ plaque deposition. Notably, this probe can also be applied to measuring CTGF on postmortem brain sections by multimodal analysis, including fluorescence imaging, peroxidase-like chromogenic imaging, and ICP-MS quantitation, which enables distinguishment between the brains of AD patients and healthy people. This probe possesses great potential for precise diagnosis of earlier AD before Aβ plaque formation.
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- 2024
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3. Visual genetic typing of glioma using proximity‐anchored in situ spectral coding amplification
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Xiaolei Chen, Ruijie Deng, Dongdong Su, Xiaochen Ma, Xu Han, Shizheng Wang, Yuqing Xia, Zifu Yang, Ningqiang Gong, Yanwei Jia, Xueyun Gao, and Xiaojun Ren
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genetic typing ,glioma ,in situ imaging ,multiplexed detection ,RNA mutation ,Biotechnology ,TP248.13-248.65 - Abstract
Abstract Gliomas are histologically and genetically heterogeneous tumors. However, classical histopathological typing often ignores the high heterogeneity of tumors and thus cannot meet the requirements of precise pathological diagnosis. Here, proximity‐anchored in situ spectral coding amplification (ProxISCA) is proposed for multiplexed imaging of RNA mutations, enabling visual typing of brain gliomas with different pathological grades at the single‐cell and tissue levels. The ligation‐based padlock probe can discriminate one‐nucleotide variations, and the design of proximity primers enables the anchoring of amplicons on target RNA, thus improving localization accuracy. The DNA module‐based spectral coding strategy can dramatically improve the multiplexing capacity for imaging RNA mutations through one‐time labelling, with low cost and simple operation. One‐target‐one‐amplicon amplification confers ProxISCA the ability to quantify RNA mutation copy number with single‐molecule resolution. Based on this approach, it is found that gliomas with higher malignant grades express more genes with high correlation at the cellular and tissue levels and show greater cellular heterogeneity. ProxISCA provides a tool for glioma research and precise diagnosis, which can reveal the relationship between cellular heterogeneity and glioma occurrence or development and assist in pathological prognosis.
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- 2023
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4. Extended Pantograph–Catenary Arc Modeling and an Analysis of the Vehicular-Grounding Electromagnetic Transients of Electric Multiple Units
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Ke Huang and Dongdong Su
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arc extinction and arc reignition ,arc length ,arc modeling ,high-speed railway ,pantograph–catenary arcing ,train body over-voltages ,Technology - Abstract
As the operating speed of electric multiple units (EMUs) in high-speed railways increases, pantograph–catenary (PC) detachment arcing occurs frequently. The resulting vehicular-grounding electromagnetic transients are related to the dynamic characteristics of the arc length. During large detachment, the processes of arc extinction and arc reignition may occur, resulting in more severe train body (TB) over-voltages and adverse effects on some vehicular electronic devices. As an extension of the previous works, this paper aims to establish a suitable PC arc model to examine the TB transient voltages. To begin with, the arc length dynamic characteristics are reasonably analyzed to deduce the relationship between the detachment distance and the arc length via the chain arc model. Then, the dynamic characteristics of the arc length are introduced, and an arc modeling scheme is proposed to elaborate the vehicle-grid electric power model for EMUs encountering various arcing scenarios. Based on this, the transient over-voltages are analyzed, accounting for both the arc extinction and arc reignition, as well as the mutual influences of multiple detachments in a short time. The influential factors, including arc length characteristics, phase angle, excitation inductance, and grounding parameters, are also involved in the performed analyses.
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- 2024
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5. Enhancing Liver Delivery of Gold Nanoclusters via Human Serum Albumin Encapsulation for Autoimmune Hepatitis Alleviation
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Cong Meng, Yu Liu, Yuping Ming, Cao Lu, Yanggege Li, Yulu Zhang, Dongdong Su, Xueyun Gao, and Qing Yuan
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peptide-conjugated gold nanoclusters ,autoimmune hepatitis ,liver delivery ,human serum albumin encapsulation ,IFN-γ/STAT ,Pharmacy and materia medica ,RS1-441 - Abstract
Peptide-protected gold nanoclusters (AuNCs), possessing exceptional biocompatibility and remarkable physicochemical properties, have demonstrated intrinsic pharmaceutical activity in immunomodulation, making them a highly attractive frontier in the field of nanomedicine exploration. Autoimmune hepatitis (AIH) is a serious autoimmune liver disease caused by the disruption of immune balance, for which effective treatment options are still lacking. In this study, we initially identified glutathione (GSH)-protected AuNCs as a promising nanodrug candidate for AIH alleviating in a Concanavalin A (Con A)-induced mice model. However, to enhance treatment efficiency, liver-targeted delivery needs to be improved. Therefore, human serum albumin (HSA)-encapsulated AuNCs were constructed to achieve enhanced liver targeting and more potent mitigation of Con A-induced elevations in plasma aspartate transaminase (AST), alanine transaminase (ALT), and liver injury in mice. In vivo and in vitro mechanism studies indicated that AuNCs could suppress the secretion of IFN-γ by Con A-stimulated T cells and subsequently inhibit the activation of the JAK2/STAT1 pathway and eventual hepatocyte apoptosis induced by IFN-γ. These actions ultimately protect the liver from immune cell infiltration and damage caused by Con A. These findings suggest that bio-protected AuNCs hold promise as nanodrugs for AIH therapy, with their liver targeting capabilities and therapeutic efficiency being further improved via rational surface ligand engineering.
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- 2024
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6. Image‐guided diagnosis and treatment of glioblastoma
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Yongning Bian, Yaling Wang, Xueqian Chen, Yong Zhang, Shaoqing Xiong, and Dongdong Su
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diagnosis ,glioblastoma ,image‐guided ,optical imaging ,therapy ,Biotechnology ,TP248.13-248.65 ,Medical technology ,R855-855.5 - Abstract
Abstract Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis and high recurrence rate. The presence of the blood–brain barrier (BBB) prevents diagnostic and therapeutic drugs from penetrating and working in GBM. In traditional surgical treatment, it is difficult to completely distinguish the boundary between tumor and surrounding normal tissue, resulting in incomplete resection of tumor. Therefore, the diagnosis and treatment of GBM are very challenging. Several molecular probes and nanoprobes have been reported to successfully penetrate the BBB, selectively target and accumulate in GBM to achieve in situ imaging of brain tumors, thus achieving accurate diagnosis and treatment of orthotopic or non‐orthotopic GBM. This paper reviews the advances of molecular probes and nanoprobes in image‐guided diagnosis and treatment of GBM. The design principle, application, and advantages of each probe are enumerated in detail. Finally, the prospects and potential challenges of probes in the diagnosis and treatment of GBM are discussed with a view to further promote the study and application of novel imaging probes in GBM.
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- 2023
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7. Recent Progress in Fluorescent Probes for the Detection and Research of Hydrogen Sulfide in Cells
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Weier Liang, Yong Zhang, Shaoqing Xiong, and Dongdong Su
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hydrogen sulfide (H2S) ,fluorescent probe ,cell imaging ,Biochemistry ,QD415-436 - Abstract
Hydrogen sulfide (H2S) is a gaseous signaling molecule that plays an important role in regulating various physiological activities in biological systems. As the fundamental structural and functional unit of organisms, cells are closely related to the homeostasis of their internal environment. The levels of H2S in different organelles maintain a certain balance, and any disruption of this balance will lead to various functional abnormalities that affect the health of organisms. Fluorescent imaging technology provides unique merits, such as simplicity, non-invasiveness, and real-time monitoring, and has become a powerful approach for the detection of molecules in biological systems. Based on the special physicochemical properties of H2S, numerous H2S-specific fluorogenic probes have been designed with different recognition mechanisms that enable rapid and accurate detection of H2S in cells. Therefore, this review briefly illustrates the design strategies, response principles, and biological applications of H2S-specific fluorescent probes and aims to provide relevant researchers with insight for future research.
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- 2023
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8. Optimal Cooperative Wireless Communication for Mobile User Data Offloading
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Guangsheng Feng, Fumin Xia, Yongmin Zhang, Dongdong Su, Haibin Lv, Huiqiang Wang, and Hongwu Lv
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Mobile data offloading ,bi-level optimization ,utility function ,user satisfaction ,cooperative transmission ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
We study the mobile data offloading problem in cooperative cellular networks, in which the cellular base station can offload a fraction of data traffic to its cooperative Wi-Fi networks. Both user satisfaction and benefit are important for the cellular network. Under the case that the cellular network cannot provide sufficient transmission resources, part of data traffic can be offloaded to its cooperative Wi-Fi networks to guarantee the user satisfaction, even though the benefit loss of the cellular network will be incurred. Meanwhile, considering the users are price sensitive, the operators, including cellular and Wi-Fi, can issue an appreciate unit price to attract more users and more traffic requirements to increase their total benefit. In this paper, we intend to design an optimal pricing scheme to maximize the user satisfaction and minimize the benefit losses of the operators simultaneously. First, we formulate the mobile data offloading problem as a joint optimization of “min–max” problem. Then, we convert the problem into a bi-level optimization problem, in which the lower level is to maximize the user satisfaction and the upper level is to minimize the benefit losses of the operators. Since the lower-level problem is convex, a centralized scheme based on the dynamic coordinate search-based method is employed to find the optimal solution of the bi-level problem. In addition, a distributed method is proposed to obtain the near-optimal solution quickly, where one-third-party agent is used to adjust the data traffic allocation. Simulation results show that the proposed method achieves the near-optimal solutions with limited iterations.
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- 2018
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9. Development of background-free tame fluorescent probes for intracellular live cell imaging
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Samira Husen Alamudi, Rudrakanta Satapathy, Jihyo Kim, Dongdong Su, Haiyan Ren, Rajkumar Das, Lingna Hu, Enrique Alvarado-Martínez, Jung Yeol Lee, Christian Hoppmann, Eduardo Peña-Cabrera, Hyung-Ho Ha, Hee-Sung Park, Lei Wang, and Young-Tae Chang
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Science - Abstract
The success of a fluorescent dye as a molecular probe to monitor the intracellular activity of biomolecules depends on its physicochemical characteristics. Here, the authors use a predictive model to identify key features that allow them to design cell permeable, background-free fluorescent probes.
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- 2016
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10. Optimal transmission for scalable video coded streaming in cellular wireless networks with the cooperation of local peer-to-peer network
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Guangsheng Feng, Junyu Lin, Qian Zhao, Huiqiang Wang, Hongwu Lv, Bingyang Li, and DongDong Su
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Electronic computers. Computer science ,QA75.5-76.95 - Abstract
We study the problem of transmitting scalable video coded streams in a hybrid scenario including a global cellular network and a local peer-to-peer network. Given desirable channel condition in cellular downlink, some cellular user equipments can fetch the video chunks via the cellular base station directly, and also provide relay service via the local peer-to-peer network for other user equipments unable to meet their basic video quality. To take the advantage of channel diversity gains, the method of random linear coding is adopted to generate linear combinations of the video chunks for transmission in both the cellular and peer-to-peer networks. To optimize the cellular and peer-to-peer transmission arrangement, we first formulate it as a mixed integer nonlinear programming problem, which becomes more complicated when the number of user equipments increases. Then, we convert it to a quasi-convex optimization problem by approximating the indicator function with a continuous step function, and it can be solved by a centralized approach. Furthermore, a primal-dual decomposition approach is developed and a distributed algorithm is proposed accordingly. Simulation results show that the proposed approach achieves a near-optimal solution.
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- 2017
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11. Spatial Magnetic-Field Description Method Aimed at 2 × 25 kV Auto-Transformer Power Supply System in High-Speed Railway
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Yunchuan Deng, Ke Huang, Dongdong Su, and Zhigang Liu
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high-speed railway (HSR) ,spatial magnetic-field description method ,auto-transformer (AT) power supply ,real loop circuits ,traction network integrated impedance ,current distribution ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Complete and accurate spatial magnetic field description is the premise of effectively assessing the power supply capability of a high-speed railway (HSR). Its evaluation indicators are the current distributions and the integrated impedance of traction network. This paper proposes a spatial magnetic-field description method for the auto-transformer (AT) power supply system. Due to the limitations of previous approaches, all the real loop circuits of the AT system are considered for structuring a loop circuit matrix. At first, different description processes are divided, respectively, into those for the right side and the left side of the load. Then, considering that two types of return conductors exist in an AT system, a certain current ratio deduced in existing studies is introduced. As the introduced current ratio of the left side of the load is approximate, an iterative scheme is adopted. By constantly adjusting current ratio to satisfy a constraint condition of circuit voltages, accurate traction network impedance is obtained. Last, in order to verify the effectiveness of the proposed description method, two real-life experiments in a Chinese HSR line are performed, which indicate that the proposed method can not only directly reflect complete and accurate current distribution, but also deduce the exact traction network integrated impedance.
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- 2018
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12. A Simple BODIPY-Based Viscosity Probe for Imaging of Cellular Viscosity in Live Cells
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Dongdong Su, Chai Lean Teoh, Nengyue Gao, Qing-Hua Xu, and Young-Tae Chang
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BODIPY ,fluorescent probes ,sensors ,viscosity ,FLIM ,cell imaging ,Chemical technology ,TP1-1185 - Abstract
Intracellular viscosity is a fundamental physical parameter that indicates the functioning of cells. In this work, we developed a simple boron-dipyrromethene (BODIPY)-based probe, BTV, for cellular mitochondria viscosity imaging by coupling a simple BODIPY rotor with a mitochondria-targeting unit. The BTV exhibited a significant fluorescence intensity enhancement of more than 100-fold as the solvent viscosity increased. Also, the probe showed a direct linear relationship between the fluorescence lifetime and the media viscosity, which makes it possible to trace the change of the medium viscosity. Furthermore, it was demonstrated that BTV could achieve practical applicability in the monitoring of mitochondrial viscosity changes in live cells through fluorescence lifetime imaging microscopy (FLIM).
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- 2016
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13. Poster: A Fast, Scalable, and Energy-efficient Edge Acceleration Architecture based on GPU Cluster.
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Yanwei Wang, Dongdong Su, Qianqian Zhao, Linge Xiao, Yanmei Shen, and Kefeng Zhu
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- 2023
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14. The deployment of FPGA Based on Network in Ultra-large-scale Data Center.
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Qianqian Zhao, Hongwei Kan, Yanwei Wang, Dongdong Su, Kefeng Zhu, and Le Yang
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- 2021
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15. HLS Based Ultra-low Latency FAST Protocol Decoder.
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Hongwei Kan, Rui Hao, Jiangwei Wang, Guoqiang Mei, Dongdong Su, and Songqing Deng
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- 2021
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16. A specification that supports FPGA devices on the TensorFlow framework.
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Hongbo Zhao, Hongwei Kan, Yanwei Wang, Qianqian Zhao, Dongdong Su, and Guangkui Huang
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- 2020
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17. Energy efficient computing offloading mechanism based on FPGA cluster for edge cloud.
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Yanwei Wang, Hongwei Kan, Dongdong Su, Yanmei Shen, Wei Liu, and Mingyang Ou
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- 2020
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18. An Optimal Design Method of Conv2d Operator for TensorFlow Based on FPGA Accelerator.
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Rengang Li, Hongwei Kan, Dongdong Su, Yanwei Wang, Hongbo Zhao, and Peilin Tong
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- 2020
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19. A joint optimization method for data offloading in D2D-enabled cellular networks.
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Guangsheng Feng, Teng Li, Dongdong Su, Haibin Lv, Huiqiang Wang, and Hongwu Lv
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- 2018
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20. A fast, scalable, and energy-efficient edge acceleration architecture based on FPGA cluster.
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Rengang Li, Dongdong Su, and Hongwei Kan
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- 2021
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21. Potential Value of Probiotics on Lipid Profiles in Hyperlipidemia and Healthy Participants: Systematic Review and Meta-Analysis.
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Dongdong Su, Yan Liu, Li Zhang, Shanshan Zhao, Yifei Wang, Rutao Bian, Bianling Xu, Xiaoyang Chen, and Xuegong Xu
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THERAPEUTIC use of probiotics , *HYPERLIPIDEMIA , *HDL cholesterol , *BLOOD lipids , *LDL cholesterol , *CHOLESTEROL , *TRIGLYCERIDES - Abstract
Objective • Many randomized controlled trials (RCTs) have reported the effect of probiotics on reducing plasma lipids with inconsistent results. An explicit systematic review and meta-analysis were conducted in this study to evaluate the effect of probiotics on the lipid profile of healthy and hyperlipidemia participants. Methods • A comprehensive literature search of RCTs was conducted using PubMed, Embase, World Health Organization (WHO) Global Index Medicus, WHO clinical trial registry, and Clinicaltrials.gov. Inclusion criteria included RCTs comparing the use of any strain of a specified probiotic with the placebo control group. The change in lipid profiles was analyzed. Results • The probiotics can decrease the total cholesterol (TC) level in hyperlipidemia participants but not healthy persons (MD = -0.43, 95% CI -0.60 – -0.25, P < .01; MD = -0.09, 95% CI -0.26 – 0.08, P > .05). Probiotics did not reduce high-density lipoprotein cholesterol (HDL-C) in patients with hyperlipidemia or healthy people (MD = -0.01, 95% CI -0.09 – 0.07, P > .05; MD = 0.02, 95% CI -0.04 – 0.09, P > .05). Furthermore, probiotics can reduce the low-density lipoprotein cholesterol (LDL-C) level both in hyperlipidemia and healthy persons (MD = -0.34, 95% CI -0.43 – -0.26, P < .01; MD = -0.15, 95% CI -0.28 – -0.02, P < .05). Lastly, the effect of probiotics on reducing triglyceride (TG) levels was significant in hyperlipidemia persons but not in the healthy population (MD = -0.20, 95% CI -0.37 – -0.04, P < .01; MD = -0.01, 95% CI -0.02 – 0.04, P > .05). Conclusions • Through our analysis, the effect of probiotics on lowering plasma lipid was more obvious in hyperlipidemia participants than healthy population. However, further studies are required to confirm the findings due to pronounced clinical heterogeneity [ABSTRACT FROM AUTHOR]
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- 2024
22. Liver-Targeted Near-Infrared Fluorescence/Photoacoustic Dual-Modal Probe for Real-Time Imaging of In Situ Hepatic Inflammation
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Yong Zhang, Wei Li, Xueqian Chen, Shaoqing Xiong, Yongning Bian, Lin Yuan, Xueyun Gao, and Dongdong Su
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Analytical Chemistry - Published
- 2023
23. A Cooperative Optimization Method for Mobile User Data Offloading.
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Guangsheng Feng, Dongdong Su, Junyu Lin, Fumin Xia, Hongwu Lv, and Huiqiang Wang
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- 2017
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24. 64Cu radiolabeled nanomaterials for positron emission tomography (PET) imaging
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Xueqian Chen, Wenchao Niu, Zhongying Du, Yong Zhang, Dongdong Su, and Xueyun Gao
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General Chemistry - Published
- 2022
25. CRISPR-Cas9 gene editing strengthens cuproptosis/chemodynamic/ferroptosis synergistic cancer therapy
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Xiaoyu Wu, Zijun Bai, Hui Wang, Hanqing Wang, Dahai Hou, Yunzhu Xu, Guanqun Wo, Haibo Cheng, Dongdong Sun, and Weiwei Tao
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GSH- and pH-responsive ,Effective copper delivery ,CRISPR-Cas9 ,ATP7A ,Cuproptosis ,Chemodynamic ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Copper-based nanomaterials demonstrate promising potential in cancer therapy. Cu+ efficiently triggers a Fenton-like reaction and further consumes the high level of glutathione, initiating chemical dynamic therapy (CDT) and ferroptosis. Cuproptosis, a newly identified cell death modality that represents a great prospect in cancer therapy, is activated. However, active homeostatic systems rigorously keep copper levels within cells exceptionally low, which hinders the application of cooper nanomaterials-based therapy. Herein, a novel strategy of CRISPR-Cas9 RNP nanocarrier to deliver cuprous ions and suppress the expression of copper transporter protein ATP7A for maintaining a high level of copper in cytoplasmic fluid is developed. The Cu2O and organosilica shell would degrade under the high level of glutathione and weak acidic environment, further releasing RNP and Cu+. The liberated Cu+ triggered a Fenton-like reaction for CDT and partially transformed to Cu2+, consuming intracellular GSH and initiating cuproptosis and ferroptosis efficiently. Meanwhile, the release of RNP effectively reduced the expression of copper transporter ATP7A, subsequently increasing the accumulation of cooper and enhancing the efficacy of CDT, cuproptosis, and ferroptosis. Such tumor microenvironment responsive multimodal nanoplatform opens an ingenious avenue for colorectal cancer therapy based on gene editing enhanced synergistic cuproptosis/CDT/ferroptosis.
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- 2024
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26. Enzyme-activated near-infrared fluorogenic probe with high-efficiency intrahepatic targeting ability for visualization of drug-induced liver injury†
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Yaling Wang, Mingrui Li, Yong Zhang, Xueqian Chen, Xueyun Gao, Dongdong Su, Qing Yuan, and Yongning Bian
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Liver injury ,chemistry.chemical_classification ,Drug ,Fluorophore ,media_common.quotation_subject ,digestive, oral, and skin physiology ,Cholic acid ,General Chemistry ,medicine.disease ,chemistry.chemical_compound ,Chemistry ,Liver targeting ,Enzyme ,chemistry ,In vivo ,medicine ,Biophysics ,Leucine ,human activities ,media_common - Abstract
Hepatotoxicity is a serious problem faced by thousands of clinical drugs, and drug-induced liver injury (DILI) caused by chronic administration or overdose has become a major biosafety issue. However, the near-infrared (NIR) fluorescent probes currently used for liver injury detection still suffer from poor liver targeting ability and low sensitivity. Enzyme-activated fluorogenic probes with powerful in situ targeting ability are the key to improving the imaging effect of liver injury. Herein, we rationally designed a leucine aminopeptidase (LAP) activated fluorogenic probe hCy-CA-LAP, which greatly improved the hepatocyte-targeting capability by introducing a cholic acid group. The probe hCy-CA-LAP is converted into a high-emission hCy-CA fluorophore in the presence of LAP, showing high selectivity, high sensitivity and low detection limit (0.0067 U mL−1) for LAP, and successfully realizes the sensitive detection of small fluctuations of LAP in living cells. Moreover, the probe can achieve effective in situ accumulation in the liver, thereby achieving precise imaging and evaluation of two different types of drug-induced hepatotoxicity in vivo. Therefore, the probe hCy-CA-LAP may be a potential tool for exploring the roles of LAP and evaluating the degree of DILI., We rationally designed a leucine aminopeptidase (LAP) activated fluorogenic probe hCy-CA-LAP with high hepatocyte-targeting ability for accurate and sensitive imaging of DILI.
- Published
- 2021
27. Multi-stage planning of integrated energy systems considering external carbon trading
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Shiyu Ji, Dongdong Su, Qianqian Song, Yibo Li, Pengxu Dong, and Yongli Wang
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- 2022
28. Intelligent Generation and Analysis of the Municipal Road Construction Scheme Based on the KNN Algorithm
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Chenzhong, Ren, primary, Wenliang, Kan, additional, Taihua, Zhou, additional, Dongdong, Su, additional, YongLi, Geng, additional, and Wenzheng, Wu, additional
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- 2022
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29. Cell membranes targeted unimolecular prodrug for programmatic photodynamic-chemo therapy
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Dongdong Su, Jie Yuan, Xiao-Bing Zhang, Xiujuan Zhuang, Hepeng Zhao, Xing-Xing Zhang, Mei Chen, Lin Yuan, and Rong Peng
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Combination therapy ,medicine.medical_treatment ,Cell ,Medicine (miscellaneous) ,Photodynamic therapy ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,two-photon photodynamic therapy ,combination therapy ,In vivo ,medicine ,Animals ,Humans ,Prodrugs ,Photosensitizer ,glutathione ,Hypoxia ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Fluorescent Dyes ,Photons ,Chemotherapy ,Photosensitizing Agents ,Singlet Oxygen ,Staining and Labeling ,Tumor hypoxia ,Rhodamines ,Chemistry ,Cell Membrane ,Mammary Neoplasms, Experimental ,Prodrug ,021001 nanoscience & nanotechnology ,humanities ,0104 chemical sciences ,medicine.anatomical_structure ,Photochemotherapy ,Cancer research ,Female ,0210 nano-technology ,Azo Compounds ,Research Paper ,HeLa Cells - Abstract
Photodynamic therapy (PDT) has emerged as one of the most up-and-coming non-invasive therapeutic modalities for cancer therapy in rencent years. However, its therapeutic effect was still hampered by the short life span, limited diffusion distance and ineluctable depletion of singlet oxygen (1O2), as well as the hypoxic microenvironment in the tumor tissue. Such problems have limited the application of PDT and appropriate solutions are highly demand. Methods: Herein, a programmatic treatment strategy is proposed for the development of a smart molecular prodrug (D-bpy), which comprise a two-photon photosensitizer and a hypoxia-activated chemotherapeutic prodrug. A rhodamine dye was designed to connect them and track the drug release by the fluorescent signal generated through azo bond cleavage. Results: The prodrug (D-bpy) can stay on the cell membrane and enrich at the tumor site. Upon light irradiation, the therapeutic effect was enhanced by a stepwise treatment: (i) direct generation of 1O2 on the cell membrane induced membrane destruction and promoted the D-bpy uptake; (ii) deep tumor hypoxia caused by two-photon PDT process further triggered the activation of the chemotherapy prodrug. Both in vitro and in vivo experiments, D-bpy have exhabited excellent tumor treatment effect. Conclusion: The innovative programmatic treatment strategy provides new strategy for the design of follow-up anticancer drugs.
- Published
- 2021
30. Study on host-guest interaction of aroma compounds/γ-cyclodextrin inclusion complexes
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Xingran Kou, Yaqi Zhang, Dongdong Su, Hui Wang, Xin Huang, Yunwei Niu, Qinfei Ke, Zuobing Xiao, and Qingran Meng
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Food Science - Published
- 2023
31. Mapping the endogenous Zn2+ in situ during zebrafish embryogenesis by a fluorogenic sensor
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Xueqian Chen, Wenchao Niu, Qing Yuan, Yong Zhang, Xueyun Gao, and Dongdong Su
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Materials Chemistry ,Metals and Alloys ,Electrical and Electronic Engineering ,Condensed Matter Physics ,Instrumentation ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Published
- 2023
32. Chemiluminescent Probes Based on 1,2-Dioxetane Structures For Bioimaging
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Yaling Wang, Yongning Bian, Xueqian Chen, and Dongdong Su
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Heterocyclic Compounds, 1-Ring ,Luminescence ,Organic Chemistry ,Luminescent Measurements ,General Chemistry ,Biochemistry ,Fluorescence - Abstract
Chemiluminescent probes based on 1,2-dioxetane scaffold are one of the most sensitive imaging modalities for detecting disease-related biomarkers and can obtain more accurate biological information in cells and in vivo. Due to the elimination of external light excitation, the background autofluorescence problem in fluorescence technology can be effectively avoided, providing ultrahigh sensitivity and signal-to-noise ratio for various applications. In this review, we highlight a comprehensive but concise overview of activatable 1,2-dioxetane-based chemiluminescent probes by reporting significant advances in accurate detection and bioimaging. The design principles and applications for reactive species, enzymes, and other disease-related biomarkers are systematically discussed and summarized. The challenges and potential prospects of chemiluminescent probes are also discussed to further promote the development of new chemiluminescence methods for biological analysis and diagnosis.
- Published
- 2022
33. Inherently PET/CT Dual Modality Imaging Lipid Nanocapsules for Early Detection of Orthotopic Lung Tumors
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Xiangchun Zhang, Pengju Cai, Zhibo Liu, Chunyu Zhang, Liang Gao, Liu Yu, Dongdong Su, Xueyun Gao, Wenjiang Yang, Fuping Gao, Hui Liu, Huaidong Jiang, and Zhesheng He
- Subjects
medicine.medical_specialty ,PET-CT ,Lung ,business.industry ,Lipid nanocapsules ,Biochemistry (medical) ,Biomedical Engineering ,Cancer ,Early detection ,General Chemistry ,Pet imaging ,medicine.disease ,Biomaterials ,medicine.anatomical_structure ,medicine ,Dual modality ,Radiology ,Stage (cooking) ,business - Abstract
Accurate diagnosis of cancer at an early stage is the key to reduce cancer mortality and improve survival. PET imaging has high sensitivity but low spatial resolution, while CT imaging has good spatial location information. Therefore, the combination of PET and CT imaging can provide complementary advantages to achieve accurate early diagnosis of tumors. However, currently developed PET or CT imaging agents have only a single function. Here, we designed and constructed a self-assembled lipid nanocapsule encapsulated with iodixanol and labeled with self-chelated
- Published
- 2022
34. Peptide and protein modified metal clusters for cancer diagnostics
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Xueyun Gao, Dongdong Su, Xiangchun Zhang, Fuping Gao, and Liang Gao
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Chemistry ,Low toxicity ,Computer science ,Nanotechnology ,General Chemistry ,Materials design ,Metal clusters - Abstract
A perspective on the development of peptide and protein modified metal clusters in cancer diagnostic applications., The biomedical features of metal clusters have been explored in tumor diagnostic applications in recent years. Peptide or protein protected metal clusters with low toxicity, ultra-small size and good biocompatibility are ideal bioanalytical tools, and exhibit better cancer diagnostic properties that have been attractive to oncologists. This perspective provides a rigorous but succinct overview of cancer diagnosis as a working concept for metal clusters by reporting the latest significant advances in the applications of metal clusters in tumor-related bioanalysis and diagnosis. The materials design principles, bioanalytical mechanisms and biomedical applications of metal clusters are described, and then the potential challenges and prospects of metal clusters in cancer diagnosis are discussed. A perspective addressing the role of metal clusters in this field is required to understand their effects and functions, as well as for the scientific community to further advance the development of metal clusters for broader diagnostic applications.
- Published
- 2020
35. Noble-metal nanocluster as enzyme-mimetic catalyst for diagnostic analysis
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Dongdong Su, Qing Yuan, ShiZheng Wang, Xueyun Gao, Liang Gao, and Xiaojun Ren
- Subjects
chemistry.chemical_classification ,Enzyme ,chemistry ,Diagnostic analysis ,General Engineering ,engineering ,General Materials Science ,Noble metal ,engineering.material ,Combinatorial chemistry ,Catalysis - Published
- 2019
36. Recent advances in molecular fluorescent probes for organic phosphate biomolecules recognition
- Author
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Dongdong Su, Shulu Yin, Xiangyang Gong, Wei Li, Lin Yuan, Xiao-Bing Zhang, and Xiaopeng Fan
- Subjects
chemistry.chemical_classification ,Biomolecule ,Signal modulation ,Nanotechnology ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Fluorescence ,0104 chemical sciences ,chemistry ,Nucleic acid ,0210 nano-technology - Abstract
Organic phosphate biomolecules (OPBs) are indispensable components of eukaryotes and prokaryotes, such as acting as the fundamental components of cell membranes and important substrates for nucleic acids. They play pivotal roles in various biological processes, such as energy conservation, metabolism, and signal modulation. Due to the difficulty of detection caused by variety OPBs, investigation of their respective physiological effects in organisms has been restrained by the lack of efficient tools. Many small fluorescent probes have been employed for selective detection and monitoring of OPBs in vitro or in vivo due to the advantages of tailored properties, biodegradability and in situ high temporal and spatial resolution imaging. In this review, we summarize the recent advances in fluorescent probes for OPBs, such as nucleotides, NAD(P)H, FAD/FMN and PS. Importantly, we describe their identification mechanisms in detail and discuss the general strategies for these OPBs probe designs, which provide new insights and ideas for the future probe designs.
- Published
- 2019
37. Activatable fluorogenic probe for accurate imaging of ulcerative colitis hypoxia
- Author
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Mingrui Li, Yong Zhang, Xiaojun Ren, Wenchao Niu, Qing Yuan, Kai Cao, Jinchao Zhang, Xueyun Gao, and Dongdong Su
- Subjects
Diagnostic Imaging ,Dextran Sulfate ,Metals and Alloys ,General Chemistry ,Nitroreductases ,Nitric Oxide ,Catalysis ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Up-Regulation ,Disease Models, Animal ,Mice ,Microscopy, Fluorescence ,A549 Cells ,Materials Chemistry ,Ceramics and Composites ,Animals ,Humans ,Colitis, Ulcerative ,Hypoxia ,Fluorescent Dyes - Abstract
An efficient probe NB-NO2 for specific imaging of ulcerative colitis via hypoxia detection was developed.
- Published
- 2021
38. A fast, scalable, and energy-efficient edge acceleration architecture based on FPGA cluster
- Author
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Dongdong Su, Hongwei Kan, and Li Rengang
- Subjects
Acceleration ,Remote direct memory access ,business.industry ,Computer science ,Server ,Embedded system ,Scalability ,Cloud computing ,Enhanced Data Rates for GSM Evolution ,Energy consumption ,business ,Efficient energy use - Abstract
FPGA-based acceleration has been emerged to avoid the cloud computing overload problem by accelerating the compute-intensive workload on edge networks. Though existing studies for FPGA-based edge acceleration have focused on optimizing the computing time, they did not address the burden of the FPGA-aided server under an enormous computing requests circumstance. The massive computing requests can cause delays in transmission and processing at the FPGA-aided server, leading to long response times and high system energy consumption. Therefore, we propose an emerging edge acceleration architecture based on FPGA cluster over the low-latency RDMA-based network. Preliminary simulation results demonstrate that our architecture is fast, scalable, and energy-efficient in comparison with the FPGA-aided servers cluster.
- Published
- 2021
39. Effects of seedling age and root pruning on root characteristics and dry matter accumulation dynamics in machine-transplanted rice
- Author
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Tingjue Wang, Wei Xiong, Fuming Kuang, Dongdong Sun, Zixuan Geng, Jinnan Que, Ruize Hou, and Dequan Zhu
- Subjects
agronomic productivity ,plant physiology ,rice yield optimisation ,stress adaptation ,transplantation techniques ,Plant culture ,SB1-1110 - Abstract
To investigate the impact of different seedling transplanting times on rice growth, the present study evaluated seedling age and root pruning using treatments consisting of root pruning (RC20, RC30, and RC40) and no root pruning (CK20, CK30, and CK40). Quantitative analysis using curve fitting of the changes in dry matter accumulation (DMA) during the seedling and field stages was performed, and the changes in root parameters during the re-greening stage were observed. The results showed that the seedling stage could be divided into a gradual increase period, a rapid increase period, and a slow increase period. Transplanting at different time periods resulted in different transplanting shock effects. During the field stage, the DMA exhibited a slow-fast-slow "S" shaped curve as the developmental time progressed. However, significant differences were observed in growth parameters among the different treatments. Root injury promoted early maturity in young seedlings but also prolonged the whole growth period in older seedlings. The inhibitory effect of root pruning on rice root growth increased with young seedling age. The present results provide a theoretical basis for the design of seedling needle structure and the optimisation of rice seedling cultivation practices.
- Published
- 2024
- Full Text
- View/download PDF
40. A fast responsive chromogenic and near-infrared fluorescence lighting-up probe for visual detection of toxic thiophenol in environmental water and living cells
- Author
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Ruilong Sheng, Juanjuan Wu, Wei Li, Lintao Zeng, João Rodrigues, Caiqin Qin, and Dongdong Su
- Subjects
Infrared Rays ,02 engineering and technology ,Wastewater ,Photochemistry ,01 natural sciences ,Chloride ,Fluorescence ,Analytical Chemistry ,chemistry.chemical_compound ,Phenols ,Environmental water ,Limit of Detection ,Oxazines ,medicine ,Humans ,Sulfhydryl Compounds ,Fluorescent Dyes ,Detection limit ,Sulfonamides ,Microscopy, Confocal ,Chromogenic ,Thiophenol ,010401 analytical chemistry ,Hydrogen-Ion Concentration ,021001 nanoscience & nanotechnology ,Nile blue ,0104 chemical sciences ,Spectrometry, Fluorescence ,Models, Chemical ,chemistry ,0210 nano-technology ,Selectivity ,Water Pollutants, Chemical ,HeLa Cells ,medicine.drug - Abstract
Thiophenols as high toxic environmental pollutants are poisonous for animals and aquatic organisms. Therefore, it is indispensable to monitor thiophenols in the environment. Herein, a novel near-infrared fluorescent probe was developed for the detection of thiophenols, which was easily prepared by one-step coupling of 2,4-dinitrobenzenesulfonyl chloride with Nile blue. The probe showed a significant near infrared (∼675 nm) fluorescence “turn-on” response to thiophenols with some good features including chromogenic reaction, high sensitivity and selectivity, fast response, near-infrared emission along with low detection limit (1.8 nM). The probe was employed to rapidly and visually determine thiophenols in several industrial wastewaters with good recoveries (90–110%). Moreover, this probe has been demonstrated good capability for imaging thiophenol in HeLa cells.
- Published
- 2019
41. Visualizing Microglia with a Fluorescence Turn‐On Ugt1a7c Substrate
- Author
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Florent Ginhoux, Jin-Soo Kim, Young-Tae Chang, Aymeric Silvin, Sungjin Park, H. Shawn Je, Masahiro Fukuda, Audrey Tze Ting Khoo, Xiao Liu, Beomsue Kim, Sejong Choi, Taejoon Kwon, Jungyeol Lee, Xiaogang Liu, Dongdong Su, Weijie Chi, Diana S. Y. Wan, and Srikanta Sanu
- Subjects
Genetically modified mouse ,Brain development ,Microglia ,010405 organic chemistry ,Chemistry ,Optical Imaging ,Chemical probe ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Fluorescence ,Catalysis ,In vitro ,0104 chemical sciences ,Mice ,medicine.anatomical_structure ,nervous system ,In vivo ,medicine ,Animals ,Macrophage ,Glucuronosyltransferase ,Neuroscience ,Fluorescent Dyes - Abstract
Microglia, the brain-resident macrophage, are involved in brain development and contribute to the progression of neural disorders. Despite the importance of microglia, imaging of live microglia at a cellular resolution has been limited to transgenic mice. Efforts have therefore been dedicated to developing new methods for microglia detection and imaging. Using a thorough structure-activity relationships study, we developed CDr20, a high-performance fluorogenic chemical probe that enables the visualization of microglia both in vitro and in vivo. Using a genome-scale CRISPR-Cas9 knockout screen, the UDP-glucuronosyltransferase Ugt1a7c was identified as the target of CDr20. The glucuronidation of CDr20 by Ugt1a7c in microglia produces fluorescence.
- Published
- 2019
42. Visualizing Microglia with a Fluorescence Turn‐On Ugt1a7c Substrate
- Author
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Beomsue Kim, Masahiro Fukuda, Jung‐Yeol Lee, Dongdong Su, Srikanta Sanu, Aymeric Silvin, Audrey T. T. Khoo, Taejoon Kwon, Xiao Liu, Weijie Chi, Xiaogang Liu, Sejong Choi, Diana S. Y. Wan, Sung‐Jin Park, Jin‐Soo Kim, Florent Ginhoux, H. Shawn Je, and Young‐Tae Chang
- Subjects
General Medicine - Published
- 2019
43. A distinctive near-infrared fluorescence turn-on probe for rapid, sensitive and chromogenic detection of sulfite in food
- Author
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Chong Duan, Guang-Ming Bao, Dongdong Su, Lintao Zeng, Jun-Feng Zhang, and Yubo Hu
- Subjects
Chromatography ,food.ingredient ,Chromogenic ,Process Chemistry and Technology ,General Chemical Engineering ,Food additive ,food and beverages ,02 engineering and technology ,Near infrared fluorescence ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Fluorescence ,0104 chemical sciences ,chemistry.chemical_compound ,Residue (chemistry) ,Visual detection ,food ,chemistry ,Sulfite ,0210 nano-technology ,Sodium sulfite - Abstract
Sodium sulfite (Na2SO3) is widely used as a food additive, but the excessive residue of SO32− in food can cause irritative effects and damages to the human body. In this study, we reported a novel near-infrared (NIR) fluorescent probe (DCMQ) for visual detection of SO32− based on a chromogenic reaction. The probe can quantitatively determine SO32− with high specificity and sensitivity, fast response (
- Published
- 2019
44. A smart fluorescent probe for discriminative detection of hydrazine and bisulfite from different emission channels
- Author
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Juanjuan Wu, Dongdong Su, Zhuo Ye, Jian Pan, and Lintao Zeng
- Subjects
Detection limit ,High selectivity ,Hydrazine ,Metals and Alloys ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Combinatorial chemistry ,Fluorescence ,Ratiometric fluorescence ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Bisulfite ,chemistry.chemical_compound ,Human health ,chemistry ,Materials Chemistry ,Electrical and Electronic Engineering ,0210 nano-technology ,Instrumentation - Abstract
Hydrazine and bisulfite are poisonous to the environment and human health, hence it is necessary to monitor hydrazine and bisulfite in the environment and living cells. In this study, we reported a smart fluorescent probe (CMCA) for discriminative detection of hydrazine and bisulfite. The single fluorescent probe can respond to hydrazine and bisulfite with two different sets of colorimetric and ratiometric fluorescence signals together with high selectivity, fast response and low detection limit. The discriminative sensing behaviors of the probe for hydrazine and bisulfite were ascribed to different reaction mechanisms, which were confirmed by 1H NMR and HR-MS spectra. The probe has been successfully used to discriminatively determine hydrazine and bisulfite in industrial wastewater with good recoveries. Furthermore, the probe was employed to visualize hydrazine and bisulfite in live cells from different fluorescence channels with good performance. Therefore, this probe has great potential applications for discriminative detection of hydrazine and bisulfite in the environment and living cells.
- Published
- 2018
45. Diversity-Oriented Fluorescence Library Approach (DOFLA) for Discovery of Cell-Permeable Probes for Applications in Live Cell Imaging
- Author
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Dongdong Su and Young-Tae Chang
- Subjects
medicine.anatomical_structure ,Chemistry ,Live cell imaging ,Cell ,medicine ,Fluorescence ,Cell biology - Published
- 2021
46. α‐Hederin induces paraptosis by targeting GPCRs to activate Ca2+/MAPK signaling pathway in colorectal cancer
- Author
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Xiwu Rao, Ziwen Li, Qinchang Zhang, Yueyang Lai, Jianrong Liu, Liu Li, Haibo Cheng, Weixing Shen, and Dongdong Sun
- Subjects
calcium ,colorectal cancer ,MAPK ,paraptosis ,α‐Hederin ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Non‐apoptotic cell death is presently emerging as a potential direction to overcome the apoptosis resistance of cancer cells. In the current study, a natural plant agent α‐hederin (α‐hed) induces caspase‐independent paraptotic modes of cell death. Purpose The present study is aimed to investigate the role of α‐hed induces paraptosis and the associated mechanism of it. Methods The cell proliferation was detected by CCK‐8. The cytoplasm organelles were observed under electron microscope. Calcium (Ca2+) level was detected by flow cytometry. Swiss Target Prediction tool analyzed the potential molecule targets of α‐hed. Molecular docking methods were used to evaluate binding abilities of α‐hed with targets. The expressions of genes and proteins were analyzed by RT‐qPCR, western blotting, immunofluorescence, and immunohistochemistry. Xenograft models in nude mice were established to evaluate the anticancer effects in vivo. Results α‐hed exerted significant cytotoxicity against a panel of CRC cell lines by inhibiting proliferation. Besides, it induced cytoplasmic vacuolation in all CRC cells. Electron microscopy images showed the aberrant dilation of endoplasmic reticulum and mitochondria. Both mRNA and protein expressions of Alg‐2 interacting proteinX (Alix), the marker of paraptosis, were inhibited by α‐hed. Besides, both Swiss prediction and molecular docking showed that the structure of α‐hed could tightly target to GPCRs. GPCRs were reported to activate the phospholipase C (PLC)‐β3/ inositol 1,4,5‐trisphosphate receptor (IP3R)/ Ca2+/ protein kinase C alpha (PKCα) pathway, and we then found all proteins and mRNA expressions of PLCβ3, IP3R, and PKCα were increased by α‐hed. After blocking the GPCR signaling, α‐hed could not elevate Ca2+ level and showed less CRC cell cytotoxicity. MAPK cascade is the symbol of paraptosis, and we then demonstrated that α‐hed activated MAPK cascade by elevating Ca2+ flux. Since non‐apoptotic cell death is presently emerging as a potential direction to overcome chemo‐drug resistance, we then found α‐hed also induced paraptosis in 5‐fluorouracil‐resistant (5‐FU‐R) CRC cells, and it reduced the growth of 5‐FU‐R CRC xenografts. Conclusions Collectively, our findings proved α‐hed as a promising candidate for inducing non‐apoptotic cell death, paraptosis. It may overcome the resistance of apoptotic‐based chemo‐resistance in CRC.
- Published
- 2024
- Full Text
- View/download PDF
47. Trusted Edge Cloud Computing Mechanism Based on FPGA Cluster
- Author
-
Shen Yanmei, Dongdong Su, Li Rengang, Wang Yanwei, Kan Hongwei, and Liu Wei
- Subjects
business.industry ,Computer science ,Cloud computing ,Encryption ,law.invention ,law ,Embedded system ,Server ,Internet Protocol ,Data center ,Enhanced Data Rates for GSM Evolution ,business ,Field-programmable gate array ,PCI Express - Abstract
To solve the problem of computing overload in cloud, we intend to design a trusted edge cloud computing model and method based on FPGA (Field Programmable Gate Array) clusters. Firstly, a device, named FPGA Box, with PCIe (Peripheral Component Interconnect Express) power supply capability is used to manage the FPGA accelerator in the model. Besides, the FPGA cluster provide heterogeneous accelerated computing services for the data center through the network. Furthermore, we proposed a trusted edge cloud computing method based on FPGA cluster. On the one hand, a bi-level encryption algorithm based on RSA is proposed to generate an authorized use code, which implied the FPGA accelerator IP (Internet Protocol) address and other information. On the other hand, based on the programmable features of the FPGA accelerators, we set FPGA registers as use status bits, which can control different working status of accelerator. Specifically, when the accelerators has been assigned, we also need upload the deadline of usage to it. Finally, the software activity process of the entire trusted edge cloud system is described in detail, including the process of generating authorized use code. Simulation results show that the edge cloud computing mechanism based on FPGA cluster is proved to be trusted and effective.
- Published
- 2020
48. Energy efficient computing offloading mechanism based on FPGA cluster for edge cloud
- Author
-
Shen Yanmei, Liu Wei, Dongdong Su, Kan Hongwei, Ou Mingyang, and Wang Yanwei
- Subjects
User information ,Computer Science::Hardware Architecture ,Task (computing) ,Computer engineering ,Computer science ,business.industry ,Data center ,Cloud computing ,Enhanced Data Rates for GSM Evolution ,Energy consumption ,business ,Field-programmable gate array ,Efficient energy use - Abstract
Towards the computing overload problem in cloud data center, we propose a computing offloading mechanism based on FPGA clusters for edge cloud. Firstly, the FPGA cluster we proposed is decoupled from traditional server, and FPGA BOX is used to power batch FPGA accelerators. The network-based FPGA cluster is deployed at the edge to undertake the computing tasks of the data center. On this basis, we propose an edge cloud network model based on FPGA clusters, and study the energy consumption minimization problem. Secondly, considering the diversity of computing tasks, the MapReduce algorithm based on the numbering mechanism proposed in this paper realizes the classification of computing tasks, and converts the energy consumption minimization problem into the energy consumption minimization problem when the user's computing tasks are determined. Based on the classification results, our improved Hungary algorithm can obtain the minimum energy consumption. Meantime, the computing task results can feedback to corresponding user according to the user information in classification results. Finally, numerical calculation results show that the computing offloading mechanism proposed in this paper shows good performance in terms of energy consumption.
- Published
- 2020
49. A specification that supports FPGA devices on the TensorFlow framework
- Author
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Wang Yanwei, Guangkui Huang, Hongbo Zhao, Kan Hongwei, Qianqian Zhao, and Dongdong Su
- Subjects
Speedup ,Artificial neural network ,Computer science ,business.industry ,Embedded system ,Process (computing) ,Inference ,Original Device ,Field-programmable gate array ,business ,MNIST database - Abstract
With the rise of artificial intelligence and machine learning, many applications and services require FPGA support to speed up the training process and improve efficiency. FPGA has its unique advantages including inference; but now TensorFlow only supports CPU and GPU, TPU, does not support FPGA, cannot use FPGA to accelerate specific models, and cannot play the full role of FPGA in TensorFlow. Based on the above problems, this paper proposes a method for efficiently using FPGA in TensorFlow. This method uses TensorFlow's original device management mechanism, adds an abstract method for FPGA devices under the TensorFlow framework, and writes implementation specifications for FPGA operators. Finally, we used OpenCL to build kernels of FPGA devices, took full advantage of the parallel computing advantages of FPGA devices, and used the CNN LeNet5 model and MNIST dataset to conduct corresponding experiments. The experimental results show that the training accuracy of the two devices is basically the same. This paper provides a feasible solution for TensorFlow to use FPGA devices for neural network calculations.
- Published
- 2020
50. An Optimal Design Method of Conv2d Operator for TensorFlow Based on FPGA Accelerator
- Author
-
Dongdong Su, Kan Hongwei, Wang Yanwei, Hongbo Zhao, Li Rengang, and Tong Peilin
- Subjects
Optimal design ,Operator (computer programming) ,Artificial neural network ,Computer science ,Node (networking) ,Central processing unit ,Parallel computing ,General-purpose computing on graphics processing units ,Field-programmable gate array ,MNIST database - Abstract
Currently, TensorFlow architecture only supports CPU and GPU programming, and has not yet formed a unified support standard for FPGAs. To the best of our knowledge, when forward operators in TensorFlow specifies a new device, the backward gradient operator in the same neural network cannot use the same device, which does not comply with rules about node device allocation in TensorFlow. Therefore, we propose an improved algorithm for node device allocation based on placement mechanism and an optimization algorithm for conv2d operator based on OpenCL. The proposed improved algorithm for node device allocation makes forward and backward operators based on FPGA accelerator satisfy the node and device allocation requirements for all TensorFlow operators, and the conv2d operator optimization algorithm based on OpenCL takes full advantage of the parallel computing advantages of FPGA. Finally, this paper uses the CNN LeNet5 model and the MNIST dataset to conduct corresponding experiments. Referring to conv2d operator, based on FPGA accelerator, we implement both the forward and backward operators involved in the first four layers of the model. The experimental results show that the accuracy of the three methods is above 98%. Compared with CPU and GPU, the accuracy difference is only about five thousandths. In addition, in the case of different batch sizes, we tested the runtime of conv2d operator in the first layer of this model. The results show that when the input batch size increased to 10000, the FPGA runs 9 times faster than the CPU. It proved that we proposed an optimization solution for TensorFlow to use FPGA operators for neural network calculations.
- Published
- 2020
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