46 results on '"DI BENEDETTO, Antonino"'
Search Results
2. Long-term benefits of dapagliflozin on renal outcomes of type 2 diabetes under routine care: a comparative effectiveness study on propensity score matched cohorts at low renal risk
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Baldassarre, Mariella, Consoli, Agostino, Morganet, Sara, Zugaro, Antonella, Baroni, Marco Giorgio, Andreozzi, Francesco, Gatti, Adriano, De Riu, Stefano, Del Buono, Andrea, Aldigeri, Raffaella, Bonadonna, Riccardo, Cas, Alessandra Dei, Vazzana, Angela, Antonini, Monica, Moretti, Valentina, Volsi, Patrizia Li, Cesare, Miranda, Zanette, Giorgio, Carletti, Silvia, D'Angelo, Paola, Leto, Gaetano, Leonetti, Frida, D'Onofrio, Luca, Maddaloni, Ernesto, Buzzetti, Raffaella, Frontoni, Simona, Cavallo, Giselle, Morano, Susanna, Filardi, Tiziana, Capece, Umberto, Giaccari, Andrea, Bossi, Antonio C., Meregalli, Giancarla, Querci, Fabrizio, Gaglio, Alessia, Resi, Veronica, Orsi, Emanuela, Fazion, Stefano, Franzetti, Ivano G., Berra, Cesare, Manfrini, Silvia, Garrapa, Gabriella, Lucarelli, Giulio, Riccialdelli, Lara, Tortato, Elena, Zavattaro, Marco, Aimaretti, Gianluca, Cavalot, Franco, Beccuti, Guglielmo, Broglio, Fabio, Fattor, Bruno, Cazzetta, Giuliana, Lamacchia, Olga, Rauseo, Anna, De Cosmo, Salvatore, Cau, Rosella, Ghiani, Mariangela, Di Benedetto, Antonino, Di Pino, Antonino, Piro, Salvatore, Purrello, Francesco, Frittitta, Lucia, Milluzzo, Agostino, Russo, Giuseppina, Fadini, Gian Paolo, Longato, Enrico, Morieri, Mario Luca, Del Prato, Stefano, Avogaro, Angelo, and Solini, Anna
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- 2024
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3. Treatment intensification following glucagon-like peptide-1 receptor agonist treatment in type 2 diabetes: The RESTORE-G real-world study
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Gabellieri, Enrico, Tortato, Elena, Rabini, Rosa Anna, Crazzolara, Dalia, Lucibelli, Luigi, Aragiusto, Concetta, Panzolato, Gianluigi, Di Mauro, Maurizio, Del Buono, Andrea, Placentino, Giuseppe, Di Cianni, Graziano, Brandoni, Gabriele, Fazion, Stefano, Gregori, Giovanna, Di Benedetto, Antonino, De Riva, Carlo, Terracciano, Annamaria, Napoli, Raffaele, Zenari, Luciano, Cavalot, Franco, Porcellati, Francesca, Anichini, Roberto, Citro, Giuseppe, D'Angelo, Paola, Arca, Marcello, Morviducci, Lelio, Montani, Valeria, Fiorentini, Paolo, Candido, Riccardo, Nicolucci, Antonio, Larosa, Monica, and Rossi, Maria Chiara
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- 2023
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4. Treatment intensification following glucagon‐like peptide‐1 receptor agonists in type 2 diabetes: Comparative effectiveness analyses between different basal insulins. RESTORE‐G real‐world study.
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Napoli, Raffaele, Nicolucci, Antonio, Larosa, Monica, Rossi, Maria Chiara, Candido, Riccardo, Aragiusto, Concetta, Arca, Marcello, Anichini, Roberto, Brandoni, Gabriele, Cavalot, Franco, Citro, Giuseppe, Crazzolara, Dalia, D'Angelo, Paola, Del Buono, Andrea, De Riva, Carlo, Di Benedetto, Antonino, Di Cianni, Graziano, Di Mauro, Maurizio, Fazion, Stefano, and Fiorentini, Paolo
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TYPE 2 diabetes ,INSULIN receptors ,PROPENSITY score matching ,ELECTRONIC health records ,BLOOD sugar - Abstract
Aim: To compare the effectiveness of different basal insulins (BI) prescribed as an add‐on to or switch from glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) therapy. Materials and Methods: Retrospective, real‐world data from electronic medical records of 32 Italian diabetes clinics were used, after propensity score adjustment, to compare effectiveness after 6 months of treatment with second‐ versus first‐generation BI (2BI vs. 1BI) or glargine 300 U/ml versus degludec 100 U/ml (Gla‐300 vs. Deg‐100), when added to (ADD‐ON) or in substitution of (SWITCH) GLP‐1 RA. Only comparisons, including a minimum of 100 patients per group, were performed to ensure adequate robustness of the analyses. Results: In the ADD‐ON cohort (N = 700), greater benefits of 2BI versus 1BI were found in glycated haemoglobin {HbA1c; estimated mean difference: −0.32% [95% confidence interval (CI) −0.62; −0.02]; p =.04} and fasting blood glucose [FBG; −20.73 mg/dl (95% CI −35.62; −5.84); p =.007]. In the SWITCH cohort (N = 2097), greater benefits of 2BI versus 1BI were found in HbA1c [−0.22% (95% CI −0.42; −0.02); p =.03], FBG [−10.15 mg/dl (95% CI −19.04; −1.26); p =.03], and body weight [−0.67 kg (95% CI −1.30; −0.04); p =.04]. In the SWITCH cohort starting 2BI (N = 688), marked differences in favour of Gla‐300 versus Deg‐100 were documented in HbA1c [−0.89% (95% CI −1.26; −0.52); p <.001] and FBG [−17.89 mg/dl (95% CI −32.45; −3.33); p =.02]. Using propensity score matching as a sensitivity analysis, the benefit on HbA1c was confirmed [−0.55% (95% CI –1.02; −0.08); p =.02]. BI titration was suboptimal in all examined cohorts. Conclusions: 2BI are a valuable option to intensify GLP‐1 RA therapy. Switching to Gla‐300 versus Deg‐100 was associated with greater HbA1c improvement. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Metabolic and clinical effect of alpha-lipoic acid administration in schizophrenic subjects stabilized with atypical antipsychotics: A 12-week, open-label, uncontrolled study
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Iannuzzo, Fiammetta, Basile, Gianpaolo Antonio, Campolo, Domenica, Genovese, Giovanni, Pandolfo, Gianluca, Giunta, Loretta, Ruggeri, Domenica, Di Benedetto, Antonino, and Bruno, Antonio
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- 2022
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6. Long-term benefits of dapagliflozin on renal outcomes of type 2 diabetes under routine care: a comparative effectiveness study on propensity score matched cohorts at low renal risk
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Fadini, Gian Paolo, primary, Longato, Enrico, additional, Morieri, Mario Luca, additional, Del Prato, Stefano, additional, Avogaro, Angelo, additional, Solini, Anna, additional, Baldassarre, Mariella, additional, Consoli, Agostino, additional, Morganet, Sara, additional, Zugaro, Antonella, additional, Baroni, Marco Giorgio, additional, Andreozzi, Francesco, additional, Gatti, Adriano, additional, De Riu, Stefano, additional, Del Buono, Andrea, additional, Aldigeri, Raffaella, additional, Bonadonna, Riccardo, additional, Cas, Alessandra Dei, additional, Vazzana, Angela, additional, Antonini, Monica, additional, Moretti, Valentina, additional, Volsi, Patrizia Li, additional, Cesare, Miranda, additional, Zanette, Giorgio, additional, Carletti, Silvia, additional, D'Angelo, Paola, additional, Leto, Gaetano, additional, Leonetti, Frida, additional, D'Onofrio, Luca, additional, Maddaloni, Ernesto, additional, Buzzetti, Raffaella, additional, Frontoni, Simona, additional, Cavallo, Giselle, additional, Morano, Susanna, additional, Filardi, Tiziana, additional, Capece, Umberto, additional, Giaccari, Andrea, additional, Bossi, Antonio C., additional, Meregalli, Giancarla, additional, Querci, Fabrizio, additional, Gaglio, Alessia, additional, Resi, Veronica, additional, Orsi, Emanuela, additional, Fazion, Stefano, additional, Franzetti, Ivano G., additional, Berra, Cesare, additional, Manfrini, Silvia, additional, Garrapa, Gabriella, additional, Lucarelli, Giulio, additional, Riccialdelli, Lara, additional, Tortato, Elena, additional, Zavattaro, Marco, additional, Aimaretti, Gianluca, additional, Cavalot, Franco, additional, Beccuti, Guglielmo, additional, Broglio, Fabio, additional, Fattor, Bruno, additional, Cazzetta, Giuliana, additional, Lamacchia, Olga, additional, Rauseo, Anna, additional, De Cosmo, Salvatore, additional, Cau, Rosella, additional, Ghiani, Mariangela, additional, Di Benedetto, Antonino, additional, Di Pino, Antonino, additional, Piro, Salvatore, additional, Purrello, Francesco, additional, Frittitta, Lucia, additional, Milluzzo, Agostino, additional, and Russo, Giuseppina, additional
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- 2024
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7. Recommendations and management of hyperglycaemia in pregnancy during COVID-19 pandemic in Italy
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Torlone, Elisabetta, Sculli, Maria Angela, Bonomo, Matteo, Di Benedetto, Antonino, Di Cianni, Graziano, Festa, Camilla, Formoso, Gloria, Lapolla, Annunziata, Mannino, Domenico, Napoli, Angela, Scavini, Marina, Succurro, Elena, Vitacolonna, Ester, and Sciacca, Laura
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- 2020
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8. Myoinositol plus α-lactalbumin supplementation, insulin resistance and birth outcomes in women with gestational diabetes mellitus: a randomized, controlled study
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D’Anna, Rosario, Corrado, Francesco, Loddo, Saverio, Gullo, Giuseppe, Giunta, Loretta, and Di Benedetto, Antonino
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- 2021
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9. Guidelines for the screening and diagnosis of gestational diabetes in Italy from 2010 to 2019: critical issues and the potential for improvement
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Vitacolonna, Ester, Succurro, Elena, Lapolla, Annunziata, Scavini, Marina, Bonomo, Matteo, Di Cianni, Graziano, Di Benedetto, Antonino, Napoli, Angela, Tumminia, Andrea, Festa, Camilla, Lencioni, Cristina, Torlone, Elisabetta, Sesti, Giorgio, Mannino, Domenico, and Purrello, Francesco
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- 2019
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10. Erectile dysfunction in compensated liver cirrhosis
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Maimone, Sergio, Saffioti, Francesca, Oliva, Giovanni, Di Benedetto, Antonino, Alibrandi, Angela, Filomia, Roberto, Caccamo, Gaia, Saitta, Carlo, Cacciola, Irene, Pitrone, Concetta, Squadrito, Giovanni, and Raimondo, Giovanni
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- 2019
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11. Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial
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Vaccaro, Olga, Masulli, Maria, Nicolucci, Antonio, Maggioni, Aldo Pietro, Sesti, Giorgio, Mocarelli, Paolo, Lucisano, Giuseppe, Sacco, Michele, Signorini, Stefano, Cappellini, Fabrizio, Riccardi, Gabriele, Boemi, Massimo, D'Angelo, Federica, Giansanti, Roberto, Tanase, Laura, Lanari, Luigi, Testa, Ivano, Ricci, Lucia, Pancani, Francesca, Ranchelli, Anna, Vagheggi, Paolo, Scatona, Alessia, Fontana, Lucia, Giorgino, Francesco, Laviola, Luigi, Tarantino, Lucia, Ippolito, Claudia, Gigantelli, Vittoria, Manicone, Mariangela, Conte, Eleonora, Trevisan, Roberto, Scaranna, Cristiana, Rota, Rossella, Corsi, Anna, Dodesini, Alessandro R., Reggiani, Giulio Marchesini, Montesi, Luca, Mazzella, Natalia, Forlani, Gabriele, Caselli, Chiara, Di Luzio, Raffaella, Mazzotti, Arianna, Aiello, Antimo, Barrea, Angelina, Musto, Antonio, D'Amico, Fiorentina, Squatrito, Sebastiano, Sinagra, Tiziana, Longhitano, Sara, Trowpea, Vanessa, Sparti, Maria, Italia, Salvatore, Lisi, Enrico, Grasso, Giuseppe, Pezzino, Vincenzo, Insalaco, Federica, Gnasso, Agostino, Carallo, Claudio, Scicchitano, Caterina, De Franceschi, Maria Serena, Santini, Costanza, Calbucci, Giovanni, Ripani, Raffaella, Corsi, Laura, Cuneo, Giacomo, Corsi, Simona, Giorda, Carlo B., Romeo, Francesco, Lesina, Annalisa, Comoglio, Marco, Bonetto, Caterina, Robusto, Anna, Nada, Elisa, Asprino, Vincenzo, Cetraro, Rosa, Impieri, Michelina, Lucchese, Giuseppe, Donnarumma, Giovanna, Tizio, Biagio, Clemente, Gennaro, Lenza, Lazzaro, Paraggio, Pia, Tomasi, Franco, Zamboni, Chiara, Dozio, Nicoletta, Scalambra, Egle, Mannucci, Edoardo, Lamanna, Caterina, Cignarelli, Mauro, Macchia, Olga La, Fariello, Stefania, Sorrentino, Maria Rosaria, Franzetti, Ivano, Radin, Raffaella, Cordera, Renzo, Annunziata, Francesca, Bonabello, Laura Affinito, Durante, Arianna, Dolcino, Mara, Gallo, Fiorenza, Mazzucchelli, Chiara, Aleo, Anna, Melga, Pierluigi, Briatore, Lucia, Maggi, Davide, Storace, Daniela, Cecoli, Francesca, Antenucci, Daniela, D'Ugo, Ercole, Pupillo, Mario, Baldassarre, Maria Pompea Antonia, Salvati, Filippo, Minnucci, Anita, De Luca, Angelo, Zugaro, Antonella, Santarelli, Livia, Bosco, Angela, Petrella, Vittorio, La Verghetta, Grazia Giovanna, Iannarelli, Rossella, De Gregorio, Antonella, D'Andrea, Settimio, Giuliani, Anna Elisa, Polidoro, w Lorella, Sperandio, Alessandra, Sciarretta, Filomena, Pezzella, Alfonso, Buzzetti, Raffaella, Carlone, Angela, Potenziani, Stella, Venditti, Chiara, Foffi, Chiara, Carbone, Salvatore, Cipolloni, Laura, Moretti, Chiara, Leto, Gaetano, Serra, Rosalia, Petrachi, Francesca, Romano, Isabella, Di Cianni, Graziano, Lacaria, Emilia, Russo, Laura, Goretti, Chiara, Sannino, Claudia, Gregori, Giovanna, Dolci, Maria, Bruselli, Laura, Mori, Mary L., Baccetti, Fabio, Del Freo, Maria, Di Benedetto, Antonino, Cucinotta, Domenico, Giunta, Loretta, Ruffo, Maria Concetta, Cannizzaro, Desiree, Pintaudi, Basilio, Perrone, Giovanni, Pata, Pietro, Ragonese, Francesco, Lettina, Gabriele, Mancuso, Teresa, Coppolino, Aldo, Piatti, Pier Marco, Monti, Lucilla, Stuccillo, Michela, Lucotti, Pietro, Setola, Manuela, Crippa, Giulia Valentina, Loi, Cinzia, Oldani, Matteo, Bottalico, Maria Luisa, Pellegata, Beatrice, Bonomo, Matteo, Menicatti, Laura Silvia Maria, Resi, Veronica, Bertuzzi, Federico, Disoteo, Eugenia Olga, Pizzi, Gianluigi, Rivellese, Angela Albarosa, Annuzzi, Giovanni, Capaldo, Brunella, Nappo, Rossella, Auciello, Stefania Michela, Turco, Anna Amelia, Costagliola, Lucia, Iovine, Ciro, Corte, Giuseppina Della, Vallefuoco, Pasquale, Nappi, Francesca, Vitale, Marilena, Cocozza, Sara, Ciano, Ornella, Massimino, Elena, Garofalo, Nadia, Avogaro, Angelo, Vedovato, Monica, Guarneri, Gabriella, Lapolla, Annunziata, Fedele, Domenico, Sartore, Giovanni, Chilelli, Nino Cristiano, Burlina, Silvia, Bonsembiante, Barbara, Giordano, Carla, Galluzzo, Aldo, Torregrossa, Vittoria, Dall'Aglio, Elisabetta, Mancastroppa, Giovanni, Arsenio, Leone, Cioni, Federico, Caronna, Silvana, Papi, Matteo, Babini, Massimiliano, Perriello, Gabriele, Santeusanio, Fausto, Calagreti, Gioia, Timi, Alessia, Tantucci, Alice, Marino, Cecilia, Consoli, Agostino, Ginestra, Federica, Di Biagio, Rosamaria, Taraborelli, Merilda, Del Prato, Stefano, Miccoli, Roberto, Bianchi, Cristina, Garofolo, Monia, Politi, Konstantina Savina, Penno, Giuseppe, Zavaroni, Donatella, Livraga, Stefania, Calzoni, Fabio, Mancastroppa, Giovanni Luigi Francesco, Anichini, Roberto, Corsini, Elisa, Tedeschi, Anna, Gaglianò, Maria Sole, Ippolito, Giulio, Salutini, Elisabetta, Citro, Giuseppe, Cervellino, Francesco, Natale, Maria, Salvatore, Vita, Zampino, Armando, Sinisi, Rosa, Calabrese, Maria, Arcangeli, Adolfo, Zogheri, Alessia, Guizzotti, Sandra, Longo, Rossella, Di Bartolo, Paolo, Pellicano, Francesca, Scolozzi, Patrizia, Termine, Simona, Luberto, Alessandra, Ballardini, Giorgio, Babini, Anna Carla, Trojani, Cristina, Mazzuca, Paolo, Bruglia, Matteo, Ciamei, Monica, Genghini, Silvia, Zannoni, Chiara, Pugliese, Giuseppe, Vitale, Martina, Rangel, Graziela, Salvi, Laura, Zappaterreno, Alessandra, Cordone, Samantha, Simonelli, Paola, Meggiorini, Marilla, Frasheri, Aurora, Di Pippo, Clelia, Maglio, Cristina, Mazzitelli, Giulia, Lauro, Davide, Rinaldi, Maria Elena, Galli, Angelica, Romano, Maria, D'Angelo, Paola, Leotta, Sergio, Suraci, Concetta, De Cosmo, Salvatore, Bacci, Simonetta, Palena, Antonio Pio, Genovese, Stefano, Mancino, Monica, Rondinelli, Maurizio, Capone, Filippo, Calabretto, Elisabetta, Bulgheroni, Monica, Bucciarelli, Loredana, Dotta, Francesco, Ceccarelli, Elena, Fondelli, Cecilia, Santacroce, Clorinda, Guarino, Elisa, Nigi, Laura, Lalli, Carlo, Di Vizia, Giovanni, Scarponi, Maura, Montani, Valeria, Di Bernardino, Paolo, Romagni, Paola, Dolcetti, Katia, Cannarsa, Emanuela, Forte, Elisa, Tamburo, Lucilla, Fornengo, Paolo, Perin, Paolo Cavallo, Prinzis, Tania, Gruden, Gabriella, Bruno, Graziella, Zucco, Chiara, Perotta, Massimo, Marena, Saverio, Monsignore, Simona, Panero, Francesco, Ponzi, Fulvia, Bossi, Antonio Carlo, Carpinteri, Rita, Casagrande, Maria Linda, Coletti, Maria Francesca, Balini, Annalisa, Filopanti, Marcello, Madaschi, Sara, Pulcina, Anna, Grimaldi, Franco, Tonutti, Laura, Venturini, Giorgio, Agus, Sandra, Pagnutti, Stefania, Guidotti, Francesca, Cavarape, Alessandro, Bonora, Enzo, Cigolini, Massimo, Pichiri, Isabella, Brangani, Corinna, Fainelli, Giulia, Tomasetto, Elena, Zoppini, Giacomo, Galletti, Anna, Perrone, Dominica, Capra, Claudio, Bianchini, Francesca, Ceseri, Martina, Di Nardo, Barbara, Sasso, Elisa, Bartolomei, Barbara, Suliman, Irina, Fabbri, Gianna, Romano, Geremia, Maturo, Nicola, Nunziata, Giuseppe, Capobianco, Giuseppe, De Simone, Giuseppina, Villa, Valeria, Rota, Giuseppe, Pentangelo, Carmine, Carbonara, Ornella, Caiazzo, Gennaro, Cutolo, Michele, Sorrentino, Tommasina, Mastrilli, Valeria, Amelia, Umberto, Masi, Stefano, Corigliano, Gerardo, Gaeta, Iole, Armentano, Vincenzo, Calatola, Pasqualino, Capuano, Gelsomina, Angiulli, Bruno, Auletta, Pasquale, Petraroli, Ettore, Iodice, Cinzia E., Agrusta, Mariano, Maggioni, Aldo P, Rivellese, Angela A, Giorda, Carlo B, La Macchia, Olga, Bossi, Antonio C, and di Bartolo, Paolo
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- 2017
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12. Treatment Intensification following Glucagon-Like Peptide-1 Receptor Agonist Treatment in Type 2 Diabetes: the RESTORE-G Real-World Study
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Candido, Riccardo, primary, Nicolucci, Antonio, additional, Larosa, Monica, additional, Rossi, Maria Chiara, additional, Napoli, Raffaele, additional, Gabellieri, Enrico, additional, Tortato, Elena, additional, Rabini, Rosa Anna, additional, Lucibelli, Luigi, additional, Aragiusto, Concetta, additional, Panzolato, Gianluigi, additional, Di Mauro, Maurizio, additional, Del Buono, Andrea, additional, Placentino, Giuseppe, additional, Brandoni, Gabriele, additional, Fazion, Stefano, additional, Gregori, Giovanna, additional, Di Benedetto, Antonino, additional, De Riva, Carlo, additional, Terracciano, Annamaria, additional, Cavalot, Franco, additional, Anichini, Roberto, additional, Citro, Giuseppe, additional, D'Angelo, Paola, additional, Arca, Marcello, additional, Morviducci, Lelio, additional, Montani, Valeria, additional, and Porcellati, Francesca, additional
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- 2023
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13. Diagnosing Gestational Diabetes with a Probably Too Simplified Diagnostic Procedure Compared to International Criteria: The Indian Case Study
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Corrado, Francesco, primary, Di Benedetto, Antonino, additional, Di Vieste, Giacoma, additional, La Fauci, Laura, additional, Martinelli, Canio, additional, D’Anna, Rosario, additional, and Pintaudi, Basilio, additional
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- 2022
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14. Comparative effectiveness of Glargine 300 U/mL vs. Degludec 100 U/mL in patients with type 2 diabetes switching from 1° generation basal insulins
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Raffaella Buzzetti, Gian Paolo Fadini, Antonio Nicolucci, Monica Larosa, Maria Chiara Rossi, Domenico Cucinotta, Gabellieri Enrico, Alpestre Mauro, Marangoni Alberto, Bassano del Grappa, Pagotto Uberto, Bongiorno Claudio, Gatta Concetta, Del Buono Andrea, Lamacchia Olga, Maiellaro Pasquale, Antenucci Daniela, Brandoni Gabriele, Borroni Francesca, Gregori Giovanna, Di Benedetto Antonino, Placentino Giuseppe, Cavalot Franco, Barale Cristina, Fadini Gian Paolo, Del Sindaco Paola, Di Loreto Chiara, Anichini Roberto, Citro Giuseppe, D'Angelo Paola, Carletti Silvia, Buzzetti Raffaella, Sterpetti Sara, Carmen Mignogna, Elli Paolo, Giuseppe Prosperini, Michele Sacco, and Giuseppe Lucisano
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Blood Glucose ,Glycated Hemoglobin A ,Basal insulin ,Degludec 100 ,Effectiveness ,Glargine 300 ,Safety ,Switch ,Type 2 diabetes ,Humans ,Hypoglycemic Agents ,Insulin Glargine ,Insulin, Long-Acting ,Retrospective Studies ,Diabetes Mellitus, Type 2 ,Hypoglycemia ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,Diabetes Mellitus ,Insulin ,Long-Acting ,Glycated Hemoglobin ,Nutrition and Dietetics ,Cardiology and Cardiovascular Medicine ,Type 2 - Abstract
Data on second generation basal insulin (2BI) in people with type 2 diabetes (T2D) generated by clinical trials still need confirmation in real-world clinical settings. This study aimed at assessing the comparative effectiveness of 2BI [Glargine 300 U/mL (Gla-300) vs. Degludec 100 U/mL (Deg-100)] in T2D Italian patients switching from first generation basal insulins (1BI).This was a retrospective, non-inferiority, multicenter study. Patients switching to Gla-300 or Deg-100 from 1BI were 1:1 propensity score matched (PSM). Changes during 6 months in continuous endpoints were assessed through linear mixed models. Incidence rates (IR) of hypoglycemia (episodes per patient-months) were compared using Poisson regression. Each PSM cohort included 593 patients. HbA1c decreased from baseline (8.7%) to 6 months by -0.58% (95%CI -0.69;-0.47) in Gla-300 group and -0.50% (95%CI -0.61;-0.39) in Deg-100 group, confirming the non-inferiority of Gla-300 vs. Deg-100. No between-group differences emerged: FBG was reduced by about 20 mg/dl with both 2BI, mean dose of 2BI (24.5 U, 0.3 U/Kg at the first prescription) was suboptimally titrated during 6 months (+1.34 U in Gla-300 and + 1.76 U in Deg-100), body weight showed minor changes. IR of hypoglycemia54 mg/dl was 0.32 (95%CI 0.21; 0.49) in Gla-300 group and 0.19 (95%CI 0.11; 0.33) in Deg-100 group (p = 0.14).In subjects with T2D, switching to 2BI from 1BI was associated with similar improvements in glycemic control, low hypoglycemia rates and no weight gain in real-life setting. Clinical inertia, represented by late treatment intensification and suboptimal titration, represents a major issue in Italy.
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- 2022
15. The Analytical Reliability of the Oral Glucose Tolerance Test for the Diagnosis of Gestational Diabetes: An Observational, Retrospective Study in a Caucasian Population
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Pintaudi, Basilio, primary, Di Vieste, Giacoma, additional, D’Anna, Rosario, additional, Chiereghin, Francesca, additional, Biamonte, Emilia, additional, Corrado, Francesco, additional, and Di Benedetto, Antonino, additional
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- 2022
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16. Hypoplastic nails and brachydactyly in a girl with moderate acne and hirsutism
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Di Bartolomeo, Luca, primary, Di Benedetto, Antonino, additional, Giunta, Loretta, additional, Guarneri, Fabrizio, additional, and Vaccaro, Mario, additional
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- 2021
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17. Serum Thyroid Hormone Autoantibodies in Type 1 Diabetes Mellitus
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Benvenga, Salvatore, Pintaudi, Basilio, Vita, Roberto, Di Vieste, Giacoma, and Di Benedetto, Antonino
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- 2015
18. The impact of clinical and psychological characteristics on alexithymia in type 1 diabetes
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Pintaudi, Basilio, Di Vieste, Giacoma, Nicolucci, Antonio, Bruno, Antonio, Genovese, Giovanni, Muscatello, Maria Rosaria Anna, Cedro, Clemente, Zoccali, Rocco Antonio, and Di Benedetto, Antonino
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Alexithymia ,BMI ,Type 1 diabetes ,Psychological outcomes ,Anxiety - Abstract
Background: Alexithymia is a psychological construct characterized by inability to express emotions, poor imagination and operational thinking. It is well known its association with several chronic disease such as Diabetes type 2, little is known about diabetes type 1. We examined the association of alexithymia with clinical and psychological outcomes in subjects with type 1 diabetes. Methods: The study was conducted in a single diabetes center. The patients fully completed a protocol composed of the following instruments: the Toronto Alexithymia Scale-20 (TAS-20), the State-Trait Anger Expression Inventory-2 (STAXI-2), the State-Trait Anxiety Inventory form Y (STAI-Y), and the Hamilton Rating Scale for Depression (HAMD). TAS-20 scores were subdivided into tertiles, Correlations and two linear regression analyses, adjusted for only clinical and clinical plus psychological characteristics, were performed. Overall, 75 patients were enrolled (mean age 41.0±11.4 years, diabetes duration 19.9±11.9 years, 49.3% males, 30.7% treated with CSII). Results: People with diabetes of the upper TAS-20 tertile had the greatest rate of depression (with the highest degree of severity) and the higher levels of anger and anxiety. There was a significant correlation between TAS-20 scores with BMI (r=0.26; p=0.03), HAMD (r=0.38; p=0.001), STAXI-2 (r=0.34; p=0.003) and STAI-Y (r=0.48; p0.0001). Further regression analysis showed TAS-20 scores were associated with BMI (beta=0.29; p=0.02). The association with BMI was confirmed (beta=0.28; p=0.007) when psychological variables are considered; furthermore, a strong association with STAI-2 (beta=0.48; p0.0001) was detected, while the analysis did reveal any significant correlation between alexithymia and HbA1c levels. Conclusions: Alexithymia is strongly associated both with clinical and psychological characteristics, notably with BMI and anxiety traits. People with diabetes type 1 should be assessed for alexithymia. Future studies on the current topic are therefore required in order to elucidate the role of alexithymia in diabetes type 1. We believe that patients with diabetes and alexithymia could take advantage of psychological counseling., Mediterranean Journal of Clinical Psychology, Vol 9, No 2 (2021)
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- 2021
19. Cluster analysis identifies patients at risk of catheter-associated urinary tract infections in intensive care units: findings from the SPIN-UTI Network
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Barchitta, M., primary, Maugeri, A., additional, Favara, G., additional, Riela, P.M., additional, La Mastra, C., additional, La Rosa, M.C., additional, San Lio, R. Magnano, additional, Gallo, G., additional, Mura, I., additional, Agodi, A., additional, Brusaferro, Marco, additional, Fenaroli, Salesia, additional, Sicoli, Ennio, additional, Montagna, Maria Teresa, additional, Squeri, Raffaele, additional, Di Bartolo, Rosario Massimo, additional, Tribastoni, Salvatore, additional, Mattaliano, Anna Rita, additional, Bellocchi, Patrizia, additional, Castiglione, Giacomo, additional, Astuto, Marinella, additional, Longhitano, Anna Maria, additional, Monea, Maria Concetta, additional, Scrofani, Giorgio, additional, Di Benedetto, Antonino, additional, Riggio, Maria Carmela, additional, Manta, Giuseppe, additional, Tetamo, Romano, additional, Dei, Ignazio, additional, Pandiani, Irene, additional, Cannistrà, Antonino, additional, Piotti, Paola, additional, Girardis, Massimo, additional, Righi, Elena, additional, Sarchi, Pierangelo, additional, Arnoldo, Luca, additional, Brusaferro, Silvio, additional, Coniglio, Salvatore, additional, Borracino, Albino, additional, Pintaudi, Sergio, additional, Minerva, Massimo, additional, Milazzo, Marina, additional, Bissolo, Emanuela, additional, Rigo, Alberto, additional, Fabiani, Leila, additional, Marinangeli, Franco, additional, Stefanini, Paolo, additional, D'Errico, Marcello Mario, additional, Donati, Abele, additional, Tardivo, Stefano, additional, Moretti, Francesca, additional, Carli, Alberto, additional, Pagliarulo, Riccardo, additional, Bianco, Aida, additional, Pavia, Maria, additional, Pasculli, Marcello, additional, Vittori, Cesare, additional, Orsi, Giovanni Battista, additional, Arrigoni, Cristina, additional, Laurenti, Patrizia, additional, Ingala, Franco, additional, and Farruggia, Patrizia, additional
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- 2021
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20. Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes – a randomized and open-label, placebo-controlled clinical trial
- Author
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Vitale, Salvatore Giovanni, primary, Corrado, Francesco, additional, Caruso, Salvatore, additional, Di Benedetto, Antonino, additional, Giunta, Loretta, additional, Cianci, Antonio, additional, and D’Anna, Rosario, additional
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- 2020
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21. Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes – a randomized and open-label, placebo-controlled clinical trial.
- Author
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Vitale, Salvatore Giovanni, Corrado, Francesco, Caruso, Salvatore, Di Benedetto, Antonino, Giunta, Loretta, Cianci, Antonio, and D'Anna, Rosario
- Subjects
GESTATIONAL diabetes ,BIOELECTRIC impedance ,OVERWEIGHT women ,BODY composition ,CLINICAL trials ,PREGNANT women - Abstract
This study aims to evaluate the effects of myo-inositol supplementation on gestational diabetes mellitus (GDM) rates and body water distribution in overweight non-obese women. 223 overweight non-obese women pregnant were randomly assigned to the treatment group (2 g of myo-inositol plus 200 µg of folic acid) or to the placebo one (200 µg of folic acid). The treatment lasted until three weeks after delivery. A tetrapolar impedance analyser was used to study body composition. The incidence of GDM was significantly reduced in the myo-inositol group compared with the placebo group. There was a significant increase in TBW, ECW and ICW values in the placebo group compared to the myo-inositol group. We have recorded a significant reduction in the overall incidence of pregnancy-induced hypertension in the myo-inositol group compared with the placebo group. Our results demonstrate the effectiveness of myo-inositol supplementation in preventing GDM in overweight non-obese pregnant women. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
- View/download PDF
22. Epidemiology of intensive care unit-acquired sepsis in Italy: Results of the SPIN-UTI network
- Author
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Agodi, Antonella, Barchitta, M., Auxilia, F., Brusaferro, S., D'Errico, M. M., Montagna, M. T., Pasquarella, C., Tardivo, S., Arrigoni, C., Fabiani, L., Laurenti, P., Mattaliano, A. R., Orsi, G. B., Squeri, R., Torregrossa, M. V., Mura, I., Aiello, Mary Rose, Alliani, Cristina, Amatucci, Maria Rita, Antoci, Manuela, Antonelli, Massimo, Astuto, Marinella, Arnoldo, Luca, Arru, Benedetto, Baccari, Giorgio, Barbadoro, Pamela, Barbara, Andrea, Barilaro, Cynthia, Battaglia, Pietro, Bellocchi, Patrizia, Bernasconi, Mara Olga, Bianco, Aida, Bissolo, Emanuela, Bocchi, Anna, Bruno, Anna, Brusaferro, Marco, Buccheri, Margherita, Campanella, Francesca, Canino, Rosario, Cannistrà, Antonino, Carini, Santa Adele, Catalano, Sebastiano, Castellani, Paola, Castiglione, Giacomo, Coniglio, Salvatore, Consolante, Ciriaco, Conte, Carmela, Contrisciani, Roberta, Corallini, Rosy, Crollari, Patricia, Damiani, Gianfranco, Denaro, Carmelo, De Remigis, Santa, Diana, Francesca, Di Bartolo, Rosario, Di Benedetto, Antonino, Di Fabio, Gianna, Di Falco, Carlo, Digeronimo, Vito, Di Gregorio, Pietro, Distefano, Roberta, Egitto, Giovanni, Falciani, Elena, Farruggia, Patrizia, Fenaroli, Salesia, Ferlazzo, Giuseppe, Garofalo, Giuseppe, Girardis, Massimo, Giovanelli, Linda, Giubbini, Gabriele, Graceffa, Adriana, Guadagna, Antonina, Gregu, Giovanna, Ingala, Franco, Innocenzi, Ludovico, La Camera, Giuseppa, La Rosa, Maria Clara, Lesa, Lucia, Longhitano, Anna Maria, Luppino, Giuseppe, Maida, Carmelo Massimo, Manta, Giuseppe, Marino, Giovanni, Masia, Maria Dolores, Maviglia, Riccardo, Mazzetti, Magda, Maugeri, Andrea, Megna, Maria Teresa, Mella, Laura Maria, Milazzo, Marina, Milia, Mario, Minari, Caterina, Minerva, Massimo, Mordacci, Marco, Murgia, Paola, Oliveri, Pietro, Olori, Maria Patrizia, Pagliarulo, Riccardo, Palermo, Rosanna, Pandiani, Irene, Pappalardo, Federico, Papetti, Cristina, Partenza, Adolfo, Pascu, Diana, Pasculli, Marcello, Pavia, Maria, Pavone, Maria Luisa, Pellegrino, Maria Giovanna, Pelligra, Fabrizio, Pillon, Danila, Pintaudi, Sergio, Pitzoi, Lucia, Pinto, Andrea, Piotti, Paola, Pupo, Simona, Quattrocchi, Rosalba, Righi, Elena, Rigo, Alberto, Rigo, Annalisa, Romeo, Antonina, Rosa, Emilio, Rutigliano, Serafina, Sarchi, Pierangelo, Scimonello, Guglielmo, Seminerio, Antonello, Stefanini, Paolo, Sticca, Giovanna, Taddei, Stefania, Tessari, Lorella, Tetamo, Romano, Ticca, Mariantonietta, Tribastoni, Salvatore, Vallorani, Sarah, Venturoni, Federica, Vitagliano, Emilia, Vitali, Pietro, Zappone, Assunta, Zei, Ettore, Zeoli, Maria Prudenzia, Agodi A., Barchitta M., Auxilia F., Brusaferro S., D'Errico M.M., Montagna M.T., Pasquarella C., Tardivo S., Arrigoni C., Fabiani L., Laurenti P., Mattaliano A.R., Orsi G.B., Squeri R., Torregrossa M.V., Mura I., Aiello M.R., Alliani C., Amatucci M.R., Antoci M., Antonelli M., Astuto M., Arnoldo L., Arru B., Baccari G., Barbadoro P., Barbara A., Barilaro C., Battaglia P., Bellocchi P., Bernasconi M.O., Bianco A., Bissolo E., Bocchi A., Bruno A., Brusaferro M., Buccheri M., Campanella F., Canino R., Cannistra A., Carini S.A., Catalano S., Castellani P., Castiglione G., Coniglio S., Consolante C., Conte C., Contrisciani R., Corallini R., Crollari P., Damiani G., Denaro C., De Remigis S., Diana F., Di Bartolo R., Di Benedetto A., Di Fabio G., Di Falco C., Digeronimo V., Di Gregorio P., Distefano R., Egitto G., Falciani E., Farruggia P., Fenaroli S., Ferlazzo G., Garofalo G., Girardis M., Giovanelli L., Giubbini G., Graceffa A., Guadagna A., Gregu G., Ingala F., Innocenzi L., La Camera G., La Rosa M.C., Lesa L., Longhitano A.M., Luppino G., Maida C.M., Manta G., Marino G., Masia M.D., Maviglia R., Mazzetti M., Maugeri A., Megna M.T., Mella L.M., Milazzo M., Milia M., Minari C., Minerva M., Mordacci M., Murgia P., Oliveri P., Olori M.P., Pagliarulo R., Palermo R., Pandiani I., Pappalardo F., Papetti C., Partenza A., Pascu D., Pasculli M., Pavia M., Pavone M.L., Pellegrino M.G., Pelligra F., Pillon D., Pintaudi S., Pitzoi L., Pinto A., Piotti P., Pupo S., Quattrocchi R., Righi E., Rigo A., Romeo A., Rosa E., Rutigliano S., Sarchi P., Scimonello G., Seminerio A., Stefanini P., Sticca G., Taddei S., Tessari L., Tetamo R., Ticca M., Tribastoni S., Vallorani S., Venturoni F., Vitagliano E., Vitali P., Zappone A., Zei E., Zeoli M.P., Agodi, A., Barchitta, M., Auxilia, F., Brusaferro, S., D'Errico, M. M., Montagna, M. T., Pasquarella, C., Tardivo, S., Arrigoni, C., Fabiani, L., Laurenti, P., Mattaliano, A. R., Orsi, G. B., Squeri, R., Torregrossa, M. V., Mura, I., Aiello, M. R., Alliani, C., Amatucci, M. R., Antoci, M., Antonelli, M., Astuto, M., Arnoldo, L., Arru, B., Baccari, G., Barbadoro, P., Barbara, A., Barilaro, C., Battaglia, P., Bellocchi, P., Bernasconi, M. O., Bianco, A., Bissolo, E., Bocchi, A., Bruno, A., Brusaferro, M., Buccheri, M., Campanella, F., Canino, R., Cannistra, A., Carini, S. A., Catalano, S., Castellani, P., Castiglione, G., Coniglio, S., Consolante, C., Conte, C., Contrisciani, R., Corallini, R., Crollari, P., Damiani, G., Denaro, C., De Remigis, S., Diana, F., Di Bartolo, R., Di Benedetto, A., Di Fabio, G., Di Falco, C., Digeronimo, V., Di Gregorio, P., Distefano, R., Egitto, G., Falciani, E., Farruggia, P., Fenaroli, S., Ferlazzo, G., Garofalo, G., Girardis, M., Giovanelli, L., Giubbini, G., Graceffa, A., Guadagna, A., Gregu, G., Ingala, F., Innocenzi, L., La Camera, G., La Rosa, M. C., Lesa, L., Longhitano, A. M., Luppino, G., Maida, C. M., Manta, G., Marino, G., Masia, M. D., Maviglia, R., Mazzetti, M., Maugeri, A., Megna, M. T., Mella, L. M., Milazzo, M., Milia, M., Minari, C., Minerva, M., Mordacci, M., Murgia, P., Oliveri, P., Olori, M. P., Pagliarulo, R., Palermo, R., Pandiani, I., Pappalardo, F., Papetti, C., Partenza, A., Pascu, D., Pasculli, M., Pavia, M., Pavone, M. L., Pellegrino, M. G., Pelligra, F., Pillon, D., Pintaudi, S., Pitzoi, L., Pinto, A., Piotti, P., Pupo, S., Quattrocchi, R., Righi, E., Rigo, A., Romeo, A., Rosa, E., Rutigliano, S., Sarchi, P., Scimonello, G., Seminerio, A., Stefanini, P., Sticca, G., Taddei, S., Tessari, L., Tetamo, R., Ticca, M., Tribastoni, S., Vallorani, S., Venturoni, F., Vitagliano, E., Vitali, P., Zappone, A., Zei, E., and Zeoli, M. P.
- Subjects
Sleep Initiation and Maintenance Disorder ,Male ,Time Factors ,Healthcare-associated infections ,Mortality ,Sepsis ,Surveillance ,Public Health, Environmental and Occupational Health ,Infectious Diseases ,Diet, Mediterranean ,Coffee ,Health Statu ,Mortality Parole chiave: Infezioni correlate all'assistenza ,Mortalità ,Sepsi ,Sorveglianza ,Academic Performance ,Prevalence ,Surveys and Questionnaire ,Hospital Mortality ,Prospective Studies ,Cross Infection ,Incidence ,Smoking ,Tryptophan ,Shock ,Middle Aged ,Shock, Septic ,Intensive Care Units ,Italy ,Population Surveillance ,Female ,Public Health ,Human ,Adult ,Employment ,Alcohol Drinking ,Intensive Care Unit ,Regression Analysi ,Young Adult ,Age Distribution ,Learning ,Humans ,Healthcare-associated infection ,Exercise ,Life Style ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Aged ,Cross-Sectional Studie ,Septic ,Environmental and Occupational Health ,Body Weight ,Length of Stay ,Body Height ,Prospective Studie ,Quality of Life ,Students, Nursing - Abstract
Background. Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units (ICUs). The main aim of the present study was to describe the epidemiology of ICU-acquired sepsis and related outcomes among patients enrolled in the framework of the Italian Nosocomial Infections Surveillance in ICUs - SPIN-UTI project. Study design. Prospective multicenter study. Methods. The SPIN-UTI network adopted the European protocols for patient-based HAI surveillance. Results. During the five editions of the SPIN-UTI project, from 2008 to 2017, 47.0% of HAIs has led to sepsis in 832 patients. Overall, 57.0% episodes were classified as sepsis, 20.5% as severe sepsis and 22.5% as septic shock. The most common isolated microorganisms from sepsis episodes were Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa. The case fatality rate increased with the severity of sepsis and the mean length of ICU-stay was significantly higher in patients with ICU-acquired sepsis than in patients without. Conclusions. Our study provides evidence that ICU-acquired sepsis occurs frequently in Italian ICU patients and is associated with a high case fatality rate and increased length of stay. However, in order to explain these findings further analyses are needed in this population of ICU patients.
- Published
- 2018
23. Phenotyping normal kidney function in elderly patients with type 2 diabetes: a cross-sectional multicentre study
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Fadini, G. P., Solini, A., Manca, M. L., Zatti, G., Karamouzis, I., Di Benedetto, A., Frittitta, L., Avogaro, A., Consoli, Agostino, Formoso, Gloria, Grossi, Giovanni, Pucci, Achiropita, Sesti, Giorgio, Andreozzi, Francesco, Capobianco, Giuseppe, Gatti, Adriano, Bonadonna, Riccardo, Zavaroni, Ivana, Dei Cas, Alessandra, Felace, Giuseppe, Li Volsi, Patrizia, Buzzetti, Raffaella, Leto, Gaetano, Sorice, Gian Pio, D’Angelo, Paola, Morano, Susanna, Bossi, Antonio Carlo, Duratorre, Edoardo, Franzetti, Ivano, Morpurgo, Paola Silvia, Orsi, Emanuela, Querci, Fabrizio, Boemi, Massimo, D’Angelo, Federica, Petrelli, Massimiliano, Aimaretti, Gianluca, Karamouzis, Ioannis, Cavalot, Franco, Saglietti, Giuseppe, Cazzetta, Giuliana, Cervone, Silvestre, Devangelio, Eleonora, Lamacchia, Olga, Arena, Salvatore, Di Benedetto, Antonino, Frittitta, Lucia, Giordano, Carla, Piro, Salvatore, Rizzo, Manfredi, Chianetta, Roberta, Mannina, Carlo, Anichini, Roberto, Penno, Giuseppe, Solini, Anna, Fattor, Bruno, Bonora, Enzo, Cigolini, Massimo, Lapolla, Annunziata, Chilelli, Nino Cristiano, Poli, Maurizio, Simioni, Natalino, Frison, Vera, Vinci, Carmela, Fadini, G P, Solini, A, Manca, M L, Zatti, G, Karamouzis, I, Di Benedetto, A, Frittitta, L, and Avogaro, A, Giordano, C
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Male ,Epidemiology ,Endocrinology, Diabetes and Metabolism ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Kidney ,Type 2 diabete ,Settore MED/13 - Endocrinologia ,0302 clinical medicine ,Endocrinology ,80 and over ,Medicine ,Diabetic Nephropathies ,030212 general & internal medicine ,Aged, 80 and over ,education.field_of_study ,General Medicine ,Insulin resistance ,Nephropathy ,Protective ,Diabetes and Metabolism ,Phenotype ,Lipotoxicity ,Female ,Type 2 ,Human ,Glomerular Filtration Rate ,medicine.medical_specialty ,Population ,Renal function ,Internal Medicine ,Diabetes Mellitus, Type 2 ,Humans ,03 medical and health sciences ,Internal medicine ,Diabetes mellitus ,Diabetes Mellitus ,education ,Aged ,business.industry ,medicine.disease ,Diabetic Nephropathie ,business ,Kidney disease - Abstract
AimsType 2 diabetes (T2D) accelerates the decline in glomerular function; however, some individuals do not develop chronic kidney disease despite advanced age and long-lasting T2D. We aimed to phenotype patients with T2D aged 80years or older who presented with a fully preserved kidney function.MethodsFrom an Italian population of 281,217 T2D outpatients, we collected data on demographics, anthropometrics, diabetes duration, HbA1c, fasting plasma glucose, lipids, liver enzymes, estimated glomerular filtration rate (eGFR), albumin excretion rate (AER), chronic complications, and medication use. We primarily compared patients with a fully preserved kidney function (eGFR>90ml/min/1.73m(2) and AER
- Published
- 2018
24. Myo-Inositol for the Prevention of Gestational Diabetes Mellitus. A Brief Review
- Author
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D’ANNA, Rosario, primary, SANTAMARIA, Angelo, additional, ALIBRANDI, Angela, additional, CORRADO, Francesco, additional, DI BENEDETTO, Antonino, additional, and FACCHINETTI, Fabio, additional
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- 2019
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25. Myoinositol plus α-lactalbumin supplementation, insulin resistance and birth outcomes in women with gestational diabetes mellitus: a randomized, controlled study.
- Author
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D'Anna, Rosario, Corrado, Francesco, Loddo, Saverio, Gullo, Giuseppe, Giunta, Loretta, and Di Benedetto, Antonino
- Subjects
INOSITOL ,LACTALBUMIN ,INSULIN resistance ,GESTATIONAL diabetes ,FOLIC acid - Abstract
To verify whether myo-inositol plus α-lactalbumin may reduce insulin resistance and excessive fetal growth in women with gestational diabetes mellitus. In a 12-month period, 120 women with a diagnosis of gestational diabetes mellitus were consecutively enrolled with an allocation of 1:1 in each group and randomly treated with myo-inositol plus α-lactalbumin plus folic acid (treated group) or folic acid (control group) for 2 months. Primary outcome was the variation of insulin resistance through the study evaluated by HOMA-IR. Secondary outcome was the evaluation, through the study, of fetal growth by ultrasound measurements of abdominal circumference centiles and estimated fat thickness. Some clinical outcomes were also considered. After 2 months, in the treated group, a significant reduction in insulin resistance (HOMA values 3.1 ± 1.4 vs 6.1 ± 3.4, p = 0.0002) and fetal growth was shown (Abdominal circumference centiles 54.9 ± 23.5 vs 67.5 ± 22.6, P = 0.006). Among clinical outcomes, a significant decrease in the rate of women who needed insulin (6.7% vs 20.3%, p = 0.03) and of pre-term birth (0 vs 15.2%, p = 0.007) was evidenced. A combination of myo-inositol and α-lactalbumin may reduce insulin resistance and excessive fetal growth. Clinical trial registration: ClinicalTrials.gov, http://www.clinicaltrials.gov, NCT 03763669, first posted date 04/12/2018; last posted date December 06/12/2018. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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26. SCLEROSTIN AND DICKKOPF-1 LEVELS IN PREGNANT WOMEN WITH GESTATIONAL DIABETES
- Author
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Catalano, Antonino, Morabito, Nunziata, LA FAUCI, MATTIA MIRIAM, Pintaudi, Basilio, Giunta, Loretta, DI BENEDETTO, Antonino, and Lasco, Antonino
- Published
- 2017
27. SCLEROSTIN AND DICKKOPF-1 IN PREGNANT WOMEN WITH GESTATIONAL DIABETES
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Catalano, Antonino, Morabito, Nunziata, Bellone, Federica, Pintaudi, B., Giunta, Loretta, Loddo, Saverio, Corrado, Francesco, D'Anna, Rosario, DI BENEDETTO, Antonino, and Lasco, Antonino
- Subjects
Dickkopf-1 ,diabetes ,Sclerostin ,wnt antagonist ,gestational diabetes ,pregnant women ,Sclerostin, Dickkopf-1, wnt antagonist, pregnant women, gestational diabetes, diabetes - Published
- 2017
28. VALUTAZIONE DEI LIVELLI DI LIPOPROTEINA(A) ED INSULINA DURANTE E DOPO LA GRAVIDANZA. DATI PRELIMINARI
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Aragona, CATERINA ORIANA, Cairo, Valentina, Scuruchi, M., Giunta, Loretta, Mamone, Federica, Savarino, F., Ardesia, Marco, Sardo, Maria Adriana, DI BENEDETTO, Antonino, Mandraffino, Giuseppe, and Saitta, Antonino
- Subjects
Lipoproteina(a) ,Insulino resistenza ,gravidanza ,Lipoproteina(a), Insulino resistenza, gravidanza - Published
- 2016
29. Dietary intake and major food sources of polyphenols in people with type 2 diabetes: The TOSCA.IT Study
- Author
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Vitale, M., Masulli, M., Rivellese, A. A., Bonora, E., Cappellini, F., Nicolucci, Andrea, Squatrito, S., Antenucci, D., Barrea, A., Bianchi, C., Bianchini, F., Fontana, L., Fornengo, P., Giorgino, F., Gnasso, A., Mannucci, E., Mazzotti, A., Nappo, R., Palena, A. P., Pata, P., Perriello, G., Potenziani, S., Radin, R., Ricci, L., Romeo, F., Santini, C., Scarponi, M., Serra, Riccardo, Timi, A., Turco, A. A., Vedovato, M., Zavaroni, D., Grioni, S., Riccardi, G., Vaccaro, O., Rivellese, Angela Albarosa, Cocozza, Sara, Auciello, Stefania, Turco, Anna Amelia, Bonora, Enzo, Cigolini, Massimo, Pichiri, Isabella, Brangani, Corinna, Tomasetto, Elena, Perriello, Gabriele, Timi, Alessia, Squatrito, Sebastiano, Sinagra, Tiziana, Longhitano, Sara, Tropea, Vanessa, Ballardini, Giorgio, Babini, Anna Carla, Ripani, Raffaella, Gregori, Giovanna, Dolci, Maria, Bruselli, Laura, Salutini, Isabella, Mori, Mary, Baccetti, Fabio, Lapolla, Annunziata, Sartore, Giovanni, Burlina, Silvia, Chilelli, Nino Cristiano, Buzzetti, Raffaella, Venditti, Chiara, Potenziani, Stella, Carlone, Angela, Galluzzo†, Aldo, Giordano, Carla, Torregrossa, Vittoria, Corsi, Laura, Cuneo, Giacomo, Corsi, Simona, Tizio, Biagio, Clemente, Gennaro, Citro, Giuseppe, Natale, Maria, Salvatore, Vita, Di Cianni, Graziano, Lacaria, Emilia, Russo, Laura, Iannarelli, Rossella, de Gregorio, Antonella, Sciarretta, Filomena, D’Andrea, Settimio, Montani, Valeria, Cannarsa, Emanuela, Dolcetti, Katia, Cordera, Renzo, Bonabello, Laura Affinito, Mazzucchelli, Chiara, Giorda, Carlo Bruno, Romeo, Francesco, Bonetto, Caterina, Antenucci, Daniela, Baldassarre, Maria Pompea Antonia, Iovine, Ciro, Nappo, Rossella, Ciano, Ornella, Dall’Aglio, Elisabetta, Mancastroppa, Giovanni, Grimaldi, Franco, Tonutti, Laura, Boemi, Massimo, D’Angelo, Federica, Leotta, Sergio, Fontana, Lucia, Lauro, Davide, Rinaldi, Maria Elena, Cignarelli, Mauro, la Macchia, Olga, Fariello, Stefania, Tomasi, Franco, Zamboni, Chiara, Dozio, Nicoletta, Trevisan, Roberto, Scaranna, Cristiana, Del Prato, Stefano, Miccoli, Roberto, Bianchi, Cristina, Garofolo, Monia, Pugliese, Giuseppe, Salvi, Laura, Rangel, Graziela, Vitale, Martina, Anichini, Roberto, Tedeschi, Anna, Corsini, Elisa, Cucinotta, Domenico, Di Benedetto, Antonino, Giunta, Loretta, Ruffo, Maria Concetta, Bossi, Antonio Carlo, Carpinter, Rita, Dotta, Francesco, Ceccarelli, Elena, Bartolo, Paolo Di, Caselli, Chiara, Luberto, Alessandra, Santini, Costanza, Mazzotti, Arianna, Calbucci, Giovanni, Consoli, Agostino, Ginestra, Federica, Calabrese, Maria, Zogheri, Alessia, Ricci, Lucia, Giorgino, Francesco, Laviola, Luigi, Ippolito, Claudia, Tarantino, Lucia, Avogaro, Angelo, Vedovato, Monica, Gnasso, Agostino, Carallo, Claudio, Scicchitano, Caterina, Zavaroni, Donatella, Livraga, Stefania, Perin, Paolo Cavallo, Forrnengo, Paolo, Prinzis, Tania, de Cosmo, Salvatore, Palena, Antonio Pio, Bacci, Simonetta, Mannucci, Edoardo, Lamanna, Caterina, Pata, Pietro, Lettina, Gabriele, Aiello, Antimo, Barrea, Angelina, Lalli, Carlo, Scarponi, Maura, Franzetti, Ivano, Radin, Raffaella, Serra, Rosalia, Petrachi, Francesca, Asprino, Vincenzo, Capra, Claudio, Forte, Elisa, Reggiani, Giulio Marchesini, Forlani, Gabriele, Montesi, Luca, Mazzella, Natalia, Piatti, Pier Marco, Monti, Lucilla, Stuccillo, Michela, Auletta, Pasquale, Petraroli, Ettore, Capobianco, Giuseppe, Romano, Geremia, Cutolo, Michele, de Simone, Giosetta, Caiazzo, Gennaro, Nunziata, Peppe, Sorrentino, Susy, Amelia, Umberto, Calatola, Pasqualino, Capuano, Gelsomina, Vitale, M, Masulli, M, Rivellese, AA, Bonora, E, Cappellini, F, Nicolucci, A, Squatrito, S, Antenucci, D, Barrea, A, Bianchi, C, Bianchini, F, Fontana, L, Fornengo,P, Giorgino, F, Gnasso, A, Mannucci, Mazzotti, A, Nappo, R, Palena, AP, Pata, P,Perriello, G, Potenziani, S, Radin, R, Ricci, L, Romeo, F, Santini, C, Scarponi, M, Serra, R, Timi, A, Turco, AA, Vedovato, M, Zavaroni, D, Grioni, S, Riccardi, G, Vaccaro, O, TOSCA.IT Study Group., Giordano, C., Rivellese, Aa, Fornengo, P, Mannucci, E, Mazzotti, A, Nappo, R, Palena, Ap, Pata, P, Perriello, G, Turco, Aa, Tosc, A. IT Study Group., Rivellese, A, Palena, A, Turco, A, Cocozza, S, Auciello, S, Cigolini, M, Pichiri, I, Brangani, C, Tomasetto, E, Sinagra, T, Longhitano, S, Tropea, V, Ballardini, G, Babini, A, Ripani, R, Gregori, G, Dolci, M, Bruselli, L, Salutini, I, Mori, M, Baccetti, F, Lapolla, A, Sartore, G, Burlina, S, Chilelli, N, Buzzetti, R, Venditti, C, Carlone, A, Galluzzo, A, Giordano, C, Torregrossa, V, Corsi, L, Cuneo, G, Corsi, S, Tizio, B, Galluzzo, G, Citro, G, Natale, M, Salvatore, V, Di Cianni, G, Lacaria, E, Russo, L, Iannarelli, R, De Gregorio, A, Sciarretta, F, D'Andrea, S, Montani, V, Cannarsa, E, Dolcetti, K, Cordera, R, Bonabello, L, Mazzucchelli, C, Giorda, C, Bonetto, C, Baldassarre, M, Iovine, C, Ciano, O, Dall'Aglio, E, Mancastroppa, G, Grimaldi, F, Tonutti, L, Boemi, M, D'Angelo, F, Leotta, S, Lauro, D, Rinaldi, M, Cignarelli, M, La Macchia, O, Fariello, S, Tomasi, F, Zamboni, C, Dozio, N, Trevisan, R, Scaranna, C, Del Prato, S, Miccoli, R, Garofolo, M, Pugliese, G, Salvi, L, Rangel, G, Anichini, R, Tedeschi, A, Corsini, E, Cucinotta, D, Di Benedetto, A, Giunta, L, Ruffo, M, Bossi, A, Carpinter, R, Dotta, F, Ceccarelli, E, Bartolo, P, Caselli, C, Luberto, A, Calbucci, G, Consoli, A, Ginestra, F, Calabrese, M, Zogheri, A, Laviola, L, Ippolito, C, Tarantino, L, Avogaro, A, Carallo, C, Scicchitano, C, Livraga, S, Perin, P, Forrnengo, P, Prinzis, T, De Cosmo, S, Bacci, S, Lamanna, C, Lettina, G, Aiello, A, Lalli, C, Franzetti, I, Petrachi, F, Asprino, V, Capra, C, Forte, E, Reggiani, G, Forlani, G, Montesi, L, Mazzella, N, Piatti, P, Monti, L, Stuccillo, M, Auletta, P, Petraroli, E, Capobianco, G, Romano, G, Cutolo, M, De Simone, G, Caiazzo, G, Nunziata, P, Sorrentino, S, Amelia, U, Calatola, P, and Capuano, G
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0301 basic medicine ,Male ,Age, BMI, Diabetes, Diet, Flavonoids, Food groups, Geographical area, Intake, Phenolic acids, Polyphenols, TOSCA.IT study, Aged, Antioxidants, Beverages, Cinnamates, Cohort Studies, Cross-Sectional Studies, Databases, Factual, Diabetes Mellitus, Type 2, Female, Flavonoids, Fruit, Glycosides, Humans, Italy, Male, Middle Aged, Nutritive Value, Phenols, Polyphenols, Diet, Diabetic, Diet, Healthy, Patient Compliance ,Settore MED/09 - Medicina Interna ,Databases, Factual ,Cross-sectional study ,Medicine (miscellaneous) ,Type 2 diabetes ,Diabete ,Antioxidants ,Settore MED/13 - Endocrinologia ,Food group ,Cohort Studies ,0302 clinical medicine ,Diet, Diabetic ,Medicine ,Food science ,Glycosides ,Age ,BMI ,Diabetes ,Diet ,Flavonoids ,Food groups ,Geographical area ,Intake ,Phenolic acids ,Polyphenols ,TOSCA.IT study ,Nutrition and Dietetics ,Phenolic acid ,food and beverages ,Middle Aged ,Polyphenols, Flavonoids, Phenolic acids, Diabetes, Food groups, Diet, Age, BMI, Geographical area, Intake, TOSCA.IT study ,Italy ,Tosca,Age,BMI,Diabetes,Diet,Flavonoids,Food groups,Geographical area,Intake,Phenolic acids,Polyphenols,TOSCA.IT study ,Cohort ,Female ,Diet, Healthy ,Nutritive Value ,Cohort study ,Polyphenol ,030209 endocrinology & metabolism ,Beverages ,03 medical and health sciences ,Phenols ,Diabetes mellitus ,Humans ,Aged ,030109 nutrition & dietetics ,business.industry ,Anthropometry ,medicine.disease ,Tosca ,Cross-Sectional Studies ,Diabetes Mellitus, Type 2 ,Cinnamates ,Fruit ,Flavonoid ,Patient Compliance ,business - Abstract
Purpose: Proper evaluation of polyphenols intake at the population level is a necessary step in order to establish possible associations with health outcomes. Available data are limited, and so far no study has been performed in people with diabetes. The aim of this work was to document the intake of polyphenols and their major food sources in a cohort of people with type 2 diabetes and in socio-demographic subgroups. Methods: We studied 2573 men and women aged 50–75 years. Among others, anthropometry was measured by standard protocol and dietary habits were investigated by food frequency questionnaire (EPIC). The intake of polyphenols was evaluated using US Department of Agriculture and Phenol-Explorer databases. Results: The mean total polyphenol intake was 683.3 ± 5.8 mg/day. Non-alcoholic beverages represented the main food source of dietary polyphenols and provided 35.5% of total polyphenol intake, followed by fruits (23.0%), alcoholic beverages (14.0%), vegetables (12.4%), cereal products and tubers (4.6%), legumes (3.7%) and oils (2.1%); chocolate, cakes and nuts are negligible sources of polyphenols in this cohort. The two most important polyphenol classes contributing to the total intake were flavonoids (47.5%) and phenolic acids (47.4%). Polyphenol intake increased with age and education level and decreased with BMI; furthermore, in the northern regions of Italy, the polyphenol intake was slightly, but significantly higher than in the central or southern regions. Conclusions: The study documents for the first time the intake of polyphenols and their main food sources in people with diabetes using validated and complete databases of the polyphenol content of food. Compared with published data, collected in people without diabetes, these results suggest a lower intake and a different pattern of intake in people with diabetes. © 2016 Springer-Verlag Berlin Heidelberg
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- 2016
30. Metabolic effects of breastfeeding in women with previous gestational diabetes diagnosed according to the IADPSG criteria
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Corrado, Francesco, primary, Giunta, Loretta, additional, Granese, Roberta, additional, Corrado, Silvia, additional, Micali, Marina, additional, Santamaria, Angelo, additional, D’Anna, Rosario, additional, and Di Benedetto, Antonino, additional
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- 2017
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31. Evaluation of Lp(a) and insulin during pregnancy in not diabetic women. Preliminary data
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Aragona, Caterina Oriana, primary, Cairo, Valentina, additional, Scuruchi, Michele, additional, Giunta, Loretta, additional, Mamone, Federica, additional, Savarino, Francesca, additional, Ardesia, Marco, additional, Loddo, Saverio, additional, Di Benedetto, Antonino, additional, Saitta, Antonino, additional, and Mandraffino, Giuseppe, additional
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- 2017
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32. Genistein Supplementation and Cardiac Function in Postmenopausal Women with Metabolic Syndrome: Results from a Pilot Strain-Echo Study
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de Gregorio, Cesare, primary, Marini, Herbert, additional, Alibrandi, Angela, additional, Di Benedetto, Antonino, additional, Bitto, Alessandra, additional, Adamo, Elena, additional, Altavilla, Domenica, additional, Irace, Concetta, additional, Di Vieste, Giacoma, additional, Pancaldo, Diego, additional, Granese, Roberta, additional, Atteritano, Marco, additional, Corrao, Salvatore, additional, Licata, Giuseppe, additional, Squadrito, Francesco, additional, and Arcoraci, Vincenzo, additional
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- 2017
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33. Peripheral blood CD34+ cells as a novel and noninvasive early marker of first trimester miscarriage: results from a case-control analysis
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Giordano, Domenico, primary, Loddo, Saverio, additional, Laganà, Antonio Simone, additional, Coppolino, Giuseppe, additional, Zoccali, Giuseppe, additional, Di Benedetto, Antonino, additional, Santamaria, Angelo, additional, Buemi, Michele, additional, and D’Anna, Rosario, additional
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- 2017
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34. Sclerostin in type 1 diabetes mellitus: gender differences and associations with clinical features, bone mass and metabolism
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Catalano, Antonino, Morabito, Nunziata, Di Vieste, G, Pintaudi, B, Giunta, Loretta, Bruno, Ml, Cucinotta, Domenico Maria, DI BENEDETTO, Antonino, and Lasco, Antonino
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bone mass ,quantitative ultrasound ,diabetes ,phalangeal ,Sclerostin ,gender difference ,wnt signalling ,Sclerostin, wnt signalling, diabetes, bone turn-over, bone mass, quantitative ultrasound, phalangeal, atherosclerosis, gender difference ,atherosclerosis ,bone turn-over - Published
- 2015
35. Metabolic effects of breastfeeding in women with previous gestational diabetes diagnosed according to the IADPSG criteria.
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Corrado, Francesco, Giunta, Loretta, Granese, Roberta, Corrado, Silvia, Micali, Marina, Santamaria, Angelo, D’Anna, Rosario, and Di Benedetto, Antonino
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BREASTFEEDING ,GESTATIONAL diabetes ,GLUCOSE tolerance tests ,TRIGLYCERIDES ,INSULIN resistance ,FASTING - Abstract
Background: Some studies have already investigated about the short-term favorable metabolic effects of breastfeeding in women with previous gestational diabetes mellitus (GDM). Aim: The aim of our study is to confirm whether the positive effects reported are maintained in the larger cohorts of patients with mild form of gestational diabetes mellitus (GDM) because recently diagnosed according to IADPSG criteria. Materials and methods: This retrospective study includes 97 evaluable consecutive women with prior GDM who have the follow-up oral glucose tolerance test at least 3 months after delivery. Fasting and 2-h plasma glucose values, homeostasis model assessment (HOMA-IR), total cholesterol, and triglycerides were obtained in pregnancy and during the post-partum control. Results: These patients were divided in 81 (83.5%) who lactate until 3 months and 16 (16.5%) who did not lactate. During pregnancy, there are no significant differences between the two groups for age, BMI, fasting and 2-h plasma glucose values, HOMA-IR, total cholesterol and triglycerides. At the postpartum control, we have at univariate analysis significant differences for all these parameters except total cholesterol. After adjustment for confounders we still have, in the breastfeeding group, HOMA-IR reduction (OR 0.370; 95% CI 0.170-0.805; p < .01) as significant independent variable, whose improvement is the most acknowledged important factor for the prevention of abnormal glucose tolerance later in life. Conclusion: These encouraging results confirm our determination to warmly advice the women affected by GDM to breastfeeding at least for 3 months. [ABSTRACT FROM AUTHOR]
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- 2019
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36. Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trial
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Santamaria, Angelo, primary, Di Benedetto, Antonino, additional, Petrella, Elisabetta, additional, Pintaudi, Basilio, additional, Corrado, Francesco, additional, D’Anna, Rosario, additional, Neri, Isabella, additional, and Facchinetti, Fabio, additional
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- 2015
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37. Myo-inositol Supplementation for Prevention of Gestational Diabetes in Obese Pregnant Women
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D'Anna, Rosario, primary, Di Benedetto, Antonino, additional, Scilipoti, Angela, additional, Santamaria, Angelo, additional, Interdonato, Maria Lieta, additional, Petrella, Elisabetta, additional, Neri, Isabella, additional, Pintaudi, Basilio, additional, Corrado, Francesco, additional, and Facchinetti, Fabio, additional
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- 2015
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38. Algorithms for personalized therapy of type 2 diabetes: results of a web-based international survey
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Gallo, Marco, primary, Mannucci, Edoardo, additional, De Cosmo, Salvatore, additional, Gentile, Sandro, additional, Candido, Riccardo, additional, De Micheli, Alberto, additional, Di Benedetto, Antonino, additional, Esposito, Katherine, additional, Genovese, Stefano, additional, Medea, Gerardo, additional, and Ceriello, Antonio, additional
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- 2015
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39. Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trial.
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Santamaria, Angelo, Di Benedetto, Antonino, Petrella, Elisabetta, Pintaudi, Basilio, Corrado, Francesco, D'Anna, Rosario, Neri, Isabella, and Facchinetti, Fabio
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INOSITOL , *GESTATIONAL diabetes , *OVERWEIGHT women , *RANDOMIZED controlled trials , *FIRST trimester of pregnancy , *THERAPEUTICS , *BLOOD sugar analysis , *VITAMIN B complex , *COMPARATIVE studies , *DIETARY supplements , *RESEARCH methodology , *MEDICAL cooperation , *OBESITY , *RESEARCH , *EVALUATION research , *BODY mass index , *DISEASE incidence , *PREVENTION , *VITAMIN therapy - Abstract
Objective: To evaluate whether myo-inositol supplementation may reduce gestational diabetes mellitus (GDM) rate in overweight women.Methods: In an open-label, randomized trial, myo-inositol (2 g plus 200 μg folic acid twice a day) or placebo (200 μg folic acid twice a day) was administered from the first trimester to delivery in pregnant overweight non-obese women (pre-pregnancy body mass index ≥ 25 and < 30 kg/m(2)). The primary outcome was the incidence of GDM.Results: From January 2012 to December 2014, 220 pregnant women were randomized at two Italian University hospitals, 110 to myo-inositol and 110 to placebo. The incidence of GDM was significantly lower in the myo-inositol group compared to the placebo group (11.6% versus 27.4%, respectively, p = 0.004). Myo-inositol treatment was associated with a 67% risk reduction of developing GDM (OR 0.33; 95% CI 0.15-0.70).Conclusions: Myo-inositol supplementation, administered since early pregnancy, reduces GDM incidence in overweight non-obese women. [ABSTRACT FROM AUTHOR]- Published
- 2016
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40. Peripheral blood CD34+ cells as a novel and noninvasive early marker of first trimester miscarriage: results from a case-control analysis.
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Giordano, Domenico, Loddo, Saverio, Laganà, Antonio Simone, Coppolino, Giuseppe, Zoccali, Giuseppe, Di Benedetto, Antonino, Santamaria, Angelo, Buemi, Michele, and D'Anna, Rosario
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MISCARRIAGE ,CD34 antigen ,BLOOD cells ,BODY mass index ,GESTATIONAL age ,BIOMARKERS ,MEMBRANE proteins ,PREVENTION - Abstract
Purpose: To evaluate the levels of peripheral blood CD34+ cells in women who subsequently had a spontaneous miscarriage (SM).Materials and Methods: We enrolled 11 women who had SM, matching them for age, BMI and gestational age with 33 healthy pregnancies (controls). From a blood sample at 9th-11th weeks of pregnancy, we evaluated PAPP-A, free β-hCG, T (suppressor and helper), NK, B, CD34+ cells.Results: In peripheral blood of women who had SM, PAPP-A and CD34+ cells were significantly lower (p < 0.001) compared to control group.Conclusions: CD34+ cell low level in peripheral blood is associated with increased risk of SM. [ABSTRACT FROM AUTHOR]- Published
- 2018
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41. Myo-inositol Supplementation for Prevention of Gestational Diabetes in Obese Pregnant Women: A Randomized Controlled Trial.
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DAnna, Rosario, Di Benedetto, Antonino, Scilipoti, Angela, Santamaria, Angelo, Interdonato, Maria Lieta, Petrella, Elisabetta, Neri, Isabella, Pintaudi, Basilio, Corrado, Francesco, Facchinetti, Fabio, DʼAnna, Rosario, and D'Anna, Rosario
- Abstract
Objective: To evaluate whether myo-inositol supplementation, an insulin sensitizer, reduces the rate of gestational diabetes mellitus (GDM) and lowers insulin resistance in obese pregnant women.Methods: In an open-label, randomized trial, myo-inositol (2 g plus 200 micrograms folic acid twice a day) or placebo (200 micrograms folic acid twice a day) was administered from the first trimester to delivery in pregnant obese women (prepregnancy body mass index 30 or greater. We calculated that 101 women in each arm would be required to demonstrate a 65% GDM reduction in the myo-inositol group with a statistical power of 80% (α=0.05). The primary outcomes were the incidence of GDM and the change in insulin resistance from enrollment until the diagnostic oral glucose tolerance test.Results: From January 2011 to April 2014, 220 pregnant women at 12-13 weeks of gestation were randomized at two Italian university hospitals, 110 to myo-inositol and 110 to placebo. Most characteristics were similar between groups. The GDM rate was significantly reduced in the myo-inositol group compared with the control group, 14.0% compared with 33.6%, respectively (P=.001; odds ratio 0.34, 95% confidence interval 0.17-0.68). Furthermore, women treated with myo-inositol showed a significantly greater reduction in the homeostasis model assessment of insulin resistance compared with the control group, -1.0±3.1 compared with 0.1±1.8 (P=.048).Conclusion: Myo-inositol supplementation, started in the first trimester, in obese pregnant women seems to reduce the incidence in GDM through a reduction of insulin resistance.Clinical Trial Registration: ClinicalTrials.gov, www.clinicaltrials.gov, NCT01047982. [ABSTRACT FROM AUTHOR]- Published
- 2015
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42. Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial
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Vaccaro, O, Masulli, M, Nicolucci, A, Bonora, E, Del Prato, S, Maggioni, Ap, Rivellese, Aa, Squatrito, S, Giorda, Cb, Sesti, G, Mocarelli, P, Lucisano, G, Sacco, M, Signorini, S, Cappellini, F, Perriello, G, Babini, Ac, Lapolla, A, Gregori, G, Giordano, C, Corsi, L, Buzzetti, R, Clemente, G, Di Cianni, G, Iannarelli, R, Cordera, R, La Macchia, O, Zamboni, C, Scaranna, C, Boemi, M, Iovine, C, Lauro, D, Leotta, S, Dall'Aglio, E, Cannarsa, E, Tonutti, L, Pugliese, G, Bossi, Ac, Anichini, R, Dotta, F, Di Benedetto, A, Citro, G, Antenucci, D, Ricci, L, Giorgino, F, Santini, C, Gnasso, A, De Cosmo, S, Zavaroni, D, Vedovato, M, Consoli, A, Calabrese, M, di Bartolo, P, Fornengo, P, Riccardi, G, IT) study group, Thiazolidinediones Or Sulfonylureas Cardiovascular Accidents Intervention Trial (TOSCA., Collaborators: Vaccaro O, Italian Diabetes Society., D'Angelo, F, Giansanti, R, Tanase, L, Lanari, L, Testa, I, Pancani, F, Ranchelli, A, Vagheggi, P, Scatona, A, Fontana, L, Laviola, L, Tarantino, L, Ippolito, C, Gigantelli, V, Manicone, M, Conte, E, Trevisan, R, Rota, R, Corsi, A, Dodesini, Ar, Reggiani, Gm, Montesi, L, Mazzella, N, Forlani, G, Caselli, C, Di Luzio, R, Mazzotti, A, Aiello, A, Barrea, A, Musto, A, D'Amico, F, Sinagra, T, Longhitano, S, Trowpea, V, Sparti, M, Italia, S, Lisi, E, Grasso, G, Pezzino, V, Insalaco, F, Carallo, C, Scicchitano, C, De Franceschi MS, Calbucci, G, Ripani, R, Cuneo, G, Corsi, S, Romeo, F, Lesina, A, Comoglio, M, Bonetto, C, Robusto, A, Nada, E, Asprino, V, Cetraro, R, Impieri, M, Lucchese, G, Donnarumma, G, Tizio, B, Lenza, L, Paraggio, P, Tomasi, F, Dozio, N, Scalambra, E, Mannucci, E, Lamanna, C, Cignarelli, M, Macchia, O, Fariello, S, Sorrentino, Mr, Franzetti, I, Radin, R, Annunziata, F, Bonabello, La, Durante, A, Dolcino, M, Gallo, F, Mazzucchelli, C, Aleo, A, Melga, P, Briatore, L, Maggi, D, Storace, D, Cecoli, F, D'Ugo, E, Pupillo, M, Baldassarre, Mpa, Salvati, F, Minnucci, A, De Luca, A, Zugaro, A, Santarelli, L, Bosco, A, Petrella, V, La Verghetta GG, De Gregorio, A, D'Andrea, S, Giuliani, Ae, Polidoro, Wl, Sperandio, A, Sciarretta, F, Pezzella, A, Carlone, A, Potenziani, S, Venditti, C, Foffi, C, Carbone, S, Cipolloni, L, Moretti, C, Leto, G, Serra, R, Petrachi, F, Romano, I, Lacaria, E, Russo, L, Goretti, C, Sannino, C, Dolci, M, Bruselli, L, Mori, Ml, Baccetti, F, Del Freo, M, Cucinotta, D, Giunta, L, Ruffo, Mc, Cannizzaro, D, Pintaudi, B, Perrone, G, Pata, P, Ragonese, F, Lettina, G, Mancuso, T, Coppolino, A, Piatti, Pm, Monti, L, Stuccillo, M, Lucotti, P, Setola, M, Crippa, Gv, Loi, C, Oldani, M, Bottalico, Ml, Pellegata, B, Bonomo, M, Menicatti, Lsm, Resi, V, Bertuzzi, F, Disoteo, Eo, Pizzi, G, Annuzzi, G, Capaldo, B, Nappo, R, Auciello, Sm, Turco, Aa, Costagliola, L, Corte, Gd, Vallefuoco, P, Nappi, F, Vitale, M, Cocozza, S, Ciano, O, Massimino, E, Garofalo, N, Avogaro, A, Guarneri, G, Fedele, D, Sartore, G, Chilelli, Nc, Burlina, S, Bonsembiante, B, Galluzzo, A, Torregrossa, V, Mancastroppa, G, 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Giovanna, Tizio, Biagio, Lenza, Lazzaro, Paraggio, Pia, Tomasi, Franco, Dozio, Nicoletta, Scalambra, Egle, Mannucci, Edoardo, Lamanna, Caterina, Cignarelli, Mauro, Macchia, Olga La, Fariello, Stefania, Sorrentino, Maria Rosaria, Franzetti, Ivano, Radin, Raffaella, Annunziata, Francesca, Bonabello, Laura Affinito, Durante, Arianna, Dolcino, Mara, Gallo, Fiorenza, Mazzucchelli, Chiara, Aleo, Anna, Melga, Pierluigi, Briatore, Lucia, Maggi, Davide, Storace, Daniela, Cecoli, Francesca, D'Ugo, Ercole, Pupillo, Mario, Baldassarre, Maria Pompea Antonia, Salvati, Filippo, Minnucci, Anita, De Luca, Angelo, Zugaro, Antonella, Santarelli, Livia, Bosco, Angela, Petrella, Vittorio, La Verghetta, Grazia Giovanna, De Gregorio, Antonella, D'Andrea, Settimio, Giuliani, Anna Elisa, Polidoro, W. Lorella, Sperandio, Alessandra, Sciarretta, Filomena, Pezzella, Alfonso, Carlone, Angela, Potenziani, Stella, Venditti, Chiara, Foffi, Chiara, Carbone, Salvatore, Cipolloni, Laura, Moretti, Chiara, Leto, Gaetano, Serra, Rosalia, Petrachi, Francesca, Romano, Isabella, Lacaria, Emilia, Russo, Laura, Goretti, Chiara, Sannino, Claudia, Dolci, Maria, Bruselli, Laura, Mori, Mary L., Baccetti, Fabio, Del Freo, Maria, Cucinotta, Domenico, Giunta, Loretta, Ruffo, Maria Concetta, Cannizzaro, Desiree, Pintaudi, Basilio, Perrone, Giovanni, Pata, Pietro, Ragonese, Francesco, Lettina, Gabriele, Mancuso, Teresa, Coppolino, Aldo, Piatti, Pier Marco, Monti, Lucilla, Stuccillo, Michela, Lucotti, Pietro, Setola, Manuela, Crippa, Giulia Valentina, Loi, Cinzia, Oldani, Matteo, Bottalico, Maria Luisa, Pellegata, Beatrice, Bonomo, Matteo, Menicatti, Laura Silvia Maria, Resi, Veronica, Bertuzzi, Federico, Disoteo, Eugenia Olga, Pizzi, Gianluigi, Rivellese, Angela Albarosa, Annuzzi, Giovanni, Capaldo, Brunella, Nappo, Rossella, Auciello, Stefania Michela, Turco, Anna Amelia, Costagliola, Lucia, Corte, Giuseppina Della, Vallefuoco, Pasquale, Nappi, Francesca, Vitale, Marilena, Cocozza, Sara, Ciano, Ornella, Massimino, Elena, Garofalo, Nadia, Avogaro, Angelo, Guarneri, Gabriella, Fedele, Domenico, Sartor, Giovanni, Chilelli, Nino Cristiano, Burlina, Silvia, Bonsembiante, Barbara, Galluzzo, Aldo, Torregrossa, Vittoria, Mancastroppa, Giovanni, Arsenio, Leone, Cioni, Federico, Caronna, Silvana, Papi, Matteo, Babini, Massimiliano, Santeusanio, Fausto, Calagreti, Gioia, Timi, Alessia, Tantucci, Alice, Marino, Cecilia, Ginestra, Federica, Di Biagio, Rosamaria, Taraborelli, Merilda, Miccoli, Roberto, Bianchi, Cristina, Garofolo, Monia, Politi, Konstantina Savina, Penno, Giuseppe, Livraga, Stefania, Calzoni, Fabio, Mancastroppa, Giovanni Luigi Francesco, Corsini, Elisa, Tedeschi, Anna, Gaglianã², Maria Sole, Ippolito, Giulio, Salutini, Elisabetta, Cervellino, Francesco, Natale, Maria, Salvatore, Vita, Zampino, Armando, Sinisi, Rosa, Arcangeli, Adolfo, Zogheri, Alessia, Guizzotti, Sandra, Longo, Rossella, Pellicano, Francesca, Scolozzi, Patrizia, Termine, Simona, Luberto, Alessandra, Ballardini, Giorgio, Trojani, Cristina, Mazzuca, Paolo, Bruglia, Matteo, Ciamei, Monica, Genghini, Silvia, Zannoni, Chiara, Vitale, Martina, Rangel, Graziela, Salvi, Laura, Zappaterreno, Alessandra, Cordone, Samantha, Simonelli, Paola, Meggiorini, Marilla, Frasheri, Aurora, Di Pippo, Clelia, Maglio, Cristina, Mazzitelli, Giulia, Rinaldi, Maria Elena, Galli, Angelica, Romano, Maria, D'Angelo, Paola, Suraci, Concetta, Bacci, Simonetta, Palena, Antonio Pio, Genovese, Stefano, Mancino, Monica, Rondinelli, Maurizio, Capone, Filippo, Calabretto, Elisabetta, Bulgheroni, Monica, Bucciarelli, Loredana, Ceccarelli, Elena, Fondelli, Cecilia, Santacroce, Clorinda, Guarino, Elisa, Nigi, Laura, Lalli, Carlo, Di Vizia, Giovanni, Scarponi, Maura, Montani, Valeria, Di Bernardino, Paolo, Romagni, Paola, Dolcetti, Katia, Forte, Elisa, Tamburo, Lucilla, Perin, Paolo Cavallo, Prinzis, Tania, Gruden, Gabriella, Bruno, Graziella, Zucco, Chiara, Perotta, Massimo, Marena, Saverio, Monsignore, Simona, Panero, Francesco, Ponzi, Fulvia, Bossi, Antonio Carlo, Carpinteri, Rita, Casagrande, Maria Linda, Coletti, Maria Francesca, Balini, Annalisa, Filopanti, Marcello, Madaschi, Sara, Pulcina, Anna, Grimaldi, Franco, Venturini, Giorgio, Agus, Sandra, Pagnutti, Stefania, Guidotti, Francesca, Cavarape, Alessandro, Cigolini, Massimo, Pichiri, Isabella, Brangani, Corinna, Fainelli, Giulia, Tomasetto, Elena, Zoppini, Giacomo, Galletti, Anna, Perrone, Dominica, Capra, Claudio, Bianchini, Francesca, Ceseri, Martina, Di Nardo, Barbara, Sasso, Elisa, Bartolomei, Barbara, Suliman, Irina, Fabbri, Gianna, Romano, Geremia, Maturo, Nicola, Nunziata, Giuseppe, Capobianco, Giuseppe, De Simone, Giuseppina, Villa, Valeria, Rota, Giuseppe, Pentangelo, Carmine, Carbonara, Ornella, Caiazzo, Gennaro, Cutolo, Michele, Sorrentino, Tommasina, Mastrilli, Valeria, Amelia, Umberto, Masi, Stefano, Corigliano, Gerardo, Gaeta, Iole, Armentano, Vincenzo, Calatola, Pasqualino, Capuano, Gelsomina, Angiulli, Bruno, Auletta, Pasquale, Petraroli, Ettore, Iodice, Cinzia E., Agrusta, Mariano, Vaccaro, O, Masulli, M, Nicolucci, A, Bonora, E, Del Prato, S, Maggioni, A, Rivellese, A, Squatrito, S, Giorda, C, Sesti, G, Mocarelli, P, Lucisano, G, Sacco, M, Signorini, S, Cappellini, F, Perriello, G, Babini, A, Lapolla, A, Gregori, G, Giordano, C, Corsi, L, Buzzetti, R, Clemente, G, Di Cianni, G, Iannarelli, R, Cordera, R, La Macchia, O, Zamboni, C, Scaranna, C, Boemi, M, Iovine, C, Lauro, D, Leotta, S, Dall'Aglio, E, Cannarsa, E, Tonutti, L, Pugliese, G, Bossi, A, Anichini, R, Dotta, F, Di Benedetto, A, Citro, G, Antenucci, D, Ricci, L, Giorgino, F, Santini, C, Gnasso, A, De Cosmo, S, Zavaroni, D, Vedovato, M, Consoli, A, Calabrese, M, di Bartolo, P, Fornengo, P, Riccardi, G, D'Angelo, F, Giansanti, R, Tanase, L, Lanari, L, Testa, I, Pancani, F, Ranchelli, A, Vagheggi, P, Scatona, A, Fontana, L, Laviola, L, Tarantino, L, Ippolito, C, Gigantelli, V, Manicone, M, Conte, E, Trevisan, R, Rota, R, Dodesini, A, Reggiani, G, Montesi, L, Mazzella, N, Forlani, G, Caselli, C, Di Luzio, R, Mazzotti, A, Aiello, A, Barrea, A, Musto, A, D'Amico, F, Sinagra, T, Longhitano, S, Trowpea, V, Sparti, M, Italia, S, Lisi, E, Grasso, G, Pezzino, V, Insalaco, F, Carallo, C, Scicchitano, C, De Franceschi, M, Calbucci, G, Ripani, R, Cuneo, G, Corsi, S, Romeo, F, Lesina, A, Comoglio, M, Bonetto, C, Robusto, A, Nada, E, Asprino, V, Cetraro, R, Impieri, M, Lucchese, G, Donnarumma, G, Tizio, B, Lenza, L, Paraggio, P, Tomasi, F, Dozio, N, Scalambra, E, Mannucci, E, Lamanna, C, Cignarelli, M, Macchia, O, Fariello, S, Sorrentino, M, Franzetti, I, Radin, R, Annunziata, F, Bonabello, L, Durante, A, Dolcino, M, Gallo, F, Mazzucchelli, C, Aleo, A, Melga, P, Briatore, L, Maggi, D, Storace, D, Cecoli, F, D'Ugo, E, Pupillo, M, Baldassarre, M, Salvati, F, Minnucci, A, De Luca, A, Zugaro, A, Santarelli, L, Bosco, A, Petrella, V, La Verghetta, G, D'Andrea, S, Giuliani, A, Polidoro, W, Sperandio, A, Sciarretta, F, Pezzella, A, Carlone, A, Potenziani, S, Venditti, C, Foffi, C, Carbone, S, Cipolloni, L, Moretti, C, Leto, G, Serra, R, Petrachi, F, Romano, I, Lacaria, E, Russo, L, Goretti, C, Sannino, C, Dolci, M, Bruselli, L, Mori, M, Baccetti, F, Del Freo, M, Cucinotta, D, Giunta, L, Ruffo, M, Cannizzaro, D, Pintaudi, B, Perrone, G, Pata, P, Ragonese, F, Lettina, G, Mancuso, T, Coppolino, A, Piatti, P, Monti, L, Stuccillo, M, Lucotti, P, Setola, M, Crippa, G, Loi, C, Oldani, M, Bottalico, M, Pellegata, B, Bonomo, M, Menicatti, L, Resi, V, Bertuzzi, F, Disoteo, E, Pizzi, G, Annuzzi, G, Capaldo, B, Nappo, R, Auciello, S, Turco, A, Costagliola, L, Corte, G, Vallefuoco, P, Nappi, F, Vitale, M, Cocozza, S, Ciano, O, Massimino, E, Garofalo, N, Avogaro, A, Guarneri, G, Fedele, D, Sartore, G, Chilelli, N, Burlina, S, Bonsembiante, B, Galluzzo, A, Torregrossa, V, Mancastroppa, G, Arsenio, L, Cioni, F, Caronna, S, Papi, M, Santeusanio, F, Calagreti, G, Timi, A, Tantucci, A, Marino, C, Ginestra, F, Di Biagio, R, Taraborelli, M, Miccoli, R, Bianchi, C, Garofolo, M, Politi, K, Penno, G, Livraga, S, Calzoni, F, Corsini, E, Tedeschi, A, Gagliano, M, Ippolito, G, Salutini, E, Cervellino, F, Natale, M, Salvatore, V, Zampino, A, Sinisi, R, Arcangeli, A, Zogheri, A, Guizzotti, S, Longo, R, Pellicano, F, Scolozzi, P, Termine, S, Luberto, A, Ballardini, G, Trojani, C, Mazzuca, P, Bruglia, M, Ciamei, M, Genghini, S, Zannoni, C, Rangel, G, Salvi, L, Zappaterreno, A, Cordone, S, Simonelli, P, Meggiorini, M, Frasheri, A, Di Pippo, C, Maglio, C, Mazzitelli, G, Rinaldi, M, Galli, A, Romano, M, D'Angelo, P, Suraci, C, Bacci, S, Palena, A, Genovese, S, Mancino, M, Rondinelli, M, Capone, F, Calabretto, E, Bulgheroni, M, Bucciarelli, L, Ceccarelli, E, Fondelli, C, Santacroce, C, Guarino, E, Nigi, L, Lalli, C, Di Vizia, G, Scarponi, M, Montani, V, Di Bernardino, P, Romagni, P, Dolcetti, K, Forte, E, Tamburo, L, Perin, P, Prinzis, T, Gruden, G, Bruno, G, Zucco, C, Perotta, M, Marena, S, Monsignore, S, Panero, F, Ponzi, F, Carpinteri, R, Casagrande, M, Coletti, M, Balini, A, Filopanti, M, Madaschi, S, Pulcina, A, Grimaldi, F, Venturini, G, Agus, S, Pagnutti, S, Guidotti, F, Cavarape, A, Cigolini, M, Pichiri, I, Brangani, C, Fainelli, G, Tomasetto, E, Zoppini, G, Galletti, A, Perrone, D, Capra, C, Bianchini, F, Ceseri, M, Di Nardo, B, Sasso, E, Bartolomei, B, Suliman, I, Fabbri, G, Romano, G, Maturo, N, Nunziata, G, Capobianco, G, De Simone, G, Villa, V, Rota, G, Pentangelo, C, Carbonara, O, Caiazzo, G, Cutolo, M, Sorrentino, T, Mastrilli, V, Amelia, U, Masi, S, Corigliano, G, Gaeta, I, Armentano, V, Calatola, P, Capuano, G, Angiulli, B, Auletta, P, Petraroli, E, Iodice, C, Agrusta, M, di Bartolo, Paolo, Polidoro, w Lorella, Sartore, Giovanni, and Gaglianò, Maria Sole
- Subjects
Male ,Diabetes and Metabolism, ipoglycemic drugs, cardiovascualr event ,Settore MED/09 - Medicina Interna ,endocrine system diseases ,IMPACT ,pioglitazone versus sulfonylureas ,Endocrinology, Diabetes and Metabolism ,GLIMEPIRIDE ,Diabetes, cardiovascular events, metformin, pioglitazone, sulphonylureas ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Internal Medicine ,Endocrinology ,law.invention ,Settore MED/13 - Endocrinologia ,Glibenclamide ,0302 clinical medicine ,Randomized controlled trial ,law ,GLYCEMIC CONTROL ,Gliclazide ,Internal medicine ,diabetes and metabolism ,RISK ,education.field_of_study ,diabetes ,Incidence ,endocrinology, diabetes and metabolism ,endocrinology ,Middle Aged ,INSULIN ,Metformin ,Treatment Outcome ,Editorial ,sulphonylureas ,Cardiovascular Diseases ,Combination ,Drug Therapy, Combination ,Female ,Type 2 ,medicine.drug ,medicine.medical_specialty ,Population ,030209 endocrinology & metabolism ,Aged ,Diabetes Mellitus, Type 2 ,Humans ,Hypoglycemic Agents ,Pioglitazone ,Sulfonylurea Compounds ,Thiazolidinediones ,Cardiovascular events ,03 medical and health sciences ,GLUCOSE-LOWERING DRUGS ,Drug Therapy ,Diabetes Mellitus ,medicine ,sulfonylureas ,education ,TOSCA.IT ,business.industry ,MORTALITY ,nutritional and metabolic diseases ,Insulin resistance ,medicine.disease ,Surgery ,Glimepiride ,business ,FOLLOW-UP - Abstract
Background The best treatment option for patients with type 2 diabetes in whom treatment with metformin alone fails to achieve adequate glycaemic control is debated. We aimed to compare the long-term effects of pioglitazone versus sulfonylureas, given in addition to metformin, on cardiovascular events in patients with type 2 diabetes. Methods TOSCA.IT was a multicentre, randomised, pragmatic clinical trial, in which patients aged 50â75 years with type 2 diabetes inadequately controlled with metformin monotherapy (2â3 g per day) were recruited from 57 diabetes clinics in Italy. Patients were randomly assigned (1:1), by permuted blocks randomisation (block size 10), stratified by site and previous cardiovascular events, to add-on pioglitazone (15â45 mg) or a sulfonylurea (5â15 mg glibenclamide, 2â6 mg glimepiride, or 30â120 mg gliclazide, in accordance with local practice). The trial was unblinded, but event adjudicators were unaware of treatment assignment. The primary outcome, assessed with a Cox proportional-hazards model, was a composite of first occurrence of all-cause death, non-fatal myocardial infarction, non-fatal stroke, or urgent coronary revascularisation, assessed in the modified intention-to-treat population (all randomly assigned participants with baseline data available and without any protocol violations in relation to inclusion or exclusion criteria). This study is registered with ClinicalTrials.gov, number NCT00700856. Findings Between Sept 18, 2008, and Jan 15, 2014, 3028 patients were randomly assigned and included in the analyses. 1535 were assigned to pioglitazone and 1493 to sulfonylureas (glibenclamide 24 [2%], glimepiride 723 [48%], gliclazide 745 [50%]). At baseline, 335 (11%) participants had a previous cardiovascular event. The study was stopped early on the basis of a futility analysis after a median follow-up of 57·3 months. The primary outcome occurred in 105 patients (1·5 per 100 person-years) who were given pioglitazone and 108 (1·5 per 100 person-years) who were given sulfonylureas (hazard ratio 0·96, 95% CI 0·74â1·26, p=0·79). Fewer patients had hypoglycaemias in the pioglitazone group than in the sulfonylureas group (148 [10%] vs 508 [34%], p
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- 2017
43. Algorithms for personalized therapy of type 2 diabetes: results of a web-based international survey
- Author
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Katherine Esposito, Antonio Ceriello, Sandro Gentile, Riccardo Candido, Alberto De Micheli, Marco Gallo, Stefano Genovese, Antonino Di Benedetto, Edoardo Mannucci, Gerardo Medea, Salvatore De Cosmo, Gallo, Marco, Mannucci, Edoardo, De Cosmo, Salvatore, Gentile, Sandro, Candido, Riccardo, De Micheli, Alberto, Di Benedetto, Antonino, Esposito, Katherine, Genovese, Stefano, Medea, Gerardo, and Ceriello, Antonio
- Subjects
Research design ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Alternative medicine ,Type 2 diabetes ,Survey Analysis ,Personalization ,Therapeutic approach ,medicine ,Web application ,Personalized therapy ,Algorithms ,Therapies ,Type 2 Diabetes ,business.industry ,medicine.disease ,Online advertising ,Pharmacology and Therapeutics ,Algorithm ,Survey Analysi ,business ,Therapie - Abstract
Objective In recent years increasing interest in the issue of treatment personalization for type 2 diabetes (T2DM) has emerged. This international web-based survey aimed to evaluate opinions of physicians about tailored therapeutic algorithms developed by the Italian Association of Diabetologists (AMD) and available online, and to get suggestions for future developments. Another aim of this initiative was to assess whether the online advertising and the survey would have increased the global visibility of the AMD algorithms. Research design and methods The web-based survey, which comprised five questions, has been available from the homepage of the web-version of the journal Diabetes Care throughout the month of December 2013, and on the AMD website between December 2013 and September 2014. Participation was totally free and responders were anonymous. Results Overall, 452 physicians (M=58.4%) participated in the survey. Diabetologists accounted for 76.8% of responders. The results of the survey show wide agreement (>90%) by participants on the utility of the algorithms proposed, even if they do not cover all possible needs of patients with T2DM for a personalized therapeutic approach. In the online survey period and in the months after its conclusion, a relevant and durable increase in the number of unique users who visited the websites was registered, compared to the period preceding the survey. Conclusions Patients with T2DM are heterogeneous, and there is interest toward accessible and easy to use personalized therapeutic algorithms. Responders opinions probably reflect the peculiar organization of diabetes care in each country.
- Published
- 2015
44. Myo-Inositol for the Prevention of Gestational Diabetes Mellitus. A Brief Review.
- Author
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D'Anna R, Santamaria A, Alibrandi A, Corrado F, DI Benedetto A, and Facchinetti F
- Subjects
- Adult, Diabetes, Gestational etiology, Female, Humans, Pregnancy, Risk Factors, Diabetes, Gestational prevention & control, Dietary Supplements, Inositol administration & dosage
- Abstract
Gestational Diabetes Mellitus (GDM) is one of the most frequent complications of pregnancy and is characterized by a carbohydrate intolerance which is diagnosed with the oral glucose tolerance test. The prevalence of GDM in our population is about 12%, but risk factors like a previous GDM, ethnicity, a parent with diabetes mellitus type 2 and maternal overweight may increase its occurrence. Complications of GDM are a pre-term birth (before 37 wk gestation), macrosomia (birth weight ≥4 kg) and gestational hypertension. Actually, GDM is principally treated with diet and, if it is necessary, with insulin; but the challenge is the prevention of GDM. Among the measures used, changes in life-style (diet+exercise) failed to prevent GDM whereas metformin showed conflicting results. A promising supplement is myo-inositol (MI) which was given from first trimester until delivery to women at risk for GDM reporting a significant decrease in GDM occurrence by more than 60% comparing to the placebo group. Recently, a secondary analysis from 3 randomized controlled trials demonstrated that MI may also significantly reduce some of GDM complications such as pre-term birth and macrosomia with a favorable impact on mother and fetus well being.
- Published
- 2019
- Full Text
- View/download PDF
45. Peripheral blood CD34 + cells as a novel and noninvasive early marker of first trimester miscarriage: results from a case-control analysis.
- Author
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Giordano D, Loddo S, Laganà AS, Coppolino G, Zoccali G, Di Benedetto A, Santamaria A, Buemi M, and D'Anna R
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- Adult, Case-Control Studies, Female, Humans, Pregnancy, Young Adult, Abortion, Spontaneous blood, Antigens, CD34 blood, Biomarkers blood, Pregnancy Trimester, First blood, Pregnancy-Associated Plasma Protein-A analysis
- Abstract
Purpose: To evaluate the levels of peripheral blood CD34
+ cells in women who subsequently had a spontaneous miscarriage (SM)., Materials and Methods: We enrolled 11 women who had SM, matching them for age, BMI and gestational age with 33 healthy pregnancies (controls). From a blood sample at 9th-11th weeks of pregnancy, we evaluated PAPP-A, free β-hCG, T (suppressor and helper), NK, B, CD34+ cells., Results: In peripheral blood of women who had SM, PAPP-A and CD34+ cells were significantly lower (p < 0.001) compared to control group., Conclusions: CD34+ cell low level in peripheral blood is associated with increased risk of SM.- Published
- 2018
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- View/download PDF
46. [Depression, anxiety and anger in patients with type 1 diabetes mellitus.]
- Author
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Muscatello MR, Troili GM, Pandolfo G, Mento C, Gallo G, Lanza G, Pintaudi B, Di Vieste G, Di Benedetto A, Zoccali RA, and Bruno A
- Subjects
- Adult, Diabetes Mellitus, Type 1 drug therapy, Female, Humans, Insulin administration & dosage, Italy, Male, Middle Aged, Psychiatric Status Rating Scales, Sex Factors, Anger, Anxiety epidemiology, Depression epidemiology, Diabetes Mellitus, Type 1 psychology
- Abstract
Introduction: The aim of this study is to evaluate the influence of negative emotions such as depression, anxiety and anger on clinical expression of type 1 diabetes, also assessing possible gender differences., Materials and Methods: 75 subjects with type 1 diabetes mellitus afferent to Diabetology Unit of the University Hospital in Messina underwent the following psychodiagnostic tests: Hamilton Rating Scale For Depression (HDRS), State-Trait Anxiety Inventory form Y (STAI-Y), State-Trait Anger Expression Inventory-2 (STAXI-2). Continuous data were expressed as mean ± standard deviation, and the comparison between groups was performed using T Student test; the data not continuous were expressed as a percentage and the differences between groups were evaluated using Chi-square test. We considered the results for values of p<0.05., Results: The mean age of 75 subjects (49.3% males) was 41.0±11.4 years, age of disease onset was 21.1 ± 11.8 years and mean duration of disease was 19.9±11.9 years; 30.7% of subjects were treated with CSII (Subcutaneus Insulin Infusion). Mild levels of depression (HDRS= 10.71±7.9) and anxiety (STAI-Y= 52.37±6.11) were found, whereas STAXI-2 subscales scores were within the normal range. Statistical analysis did not show significant gender differences., Discussion: Our results, according to data from literature, confirm the association between negative emotions, particularly anxiety, and diabetes. No gender differences were found., Conclusions: Our results suggest the importance of investigating the association between diabetes and negative emotional states and the psychological and psychopathological dimensions which may have a potential role in the therapeutic management of diabetes.
- Published
- 2017
- Full Text
- View/download PDF
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