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Your search keyword '"Cerovic, Vuk"' showing total 25 results
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25 results on '"Cerovic, Vuk"'

6. Resident regulatory T cells reflect the immune history of individual lymph nodes

Author

Kaminski, Anne, primary, Hager, Fabian Tobias, additional, Kopplin, Lydia, additional, Ticconi, Fabio, additional, Leufgen, Andrea, additional, Vendelova, Emilia, additional, Rüttger, Lennart, additional, Gasteiger, Georg, additional, Cerovic, Vuk, additional, Kastenmüller, Wolfgang, additional, Pabst, Oliver, additional, and Ugur, Milas, additional

Published
2023
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8. The renaissance of oral tolerance: merging tradition and new insights

Author

Cerovic, Vuk, Pabst, Oliver, and Mowat, Allan McI

Abstract

Oral tolerance is the process by which feeding of soluble proteins induces antigen-specific systemic immune unresponsiveness. Oral tolerance is thought to have a central role in suppressing immune responses to ‘harmless’ food antigens, and its failure can lead to development of pathologies such as food allergies or coeliac disease. However, on the basis of long-standing experimental observations, the relevance of oral tolerance in human health has achieved new prominence recently following the discovery that oral administration of peanut proteins prevents the development of peanut allergy in at-risk human infants. In this Review, we summarize the new mechanistic insights into three key processes necessary for the induction of tolerance to oral antigens: antigen uptake and transport across the small intestinal epithelial barrier to the underlying immune cells; the processing, transport and presentation of fed antigen by different populations of antigen-presenting cells; and the development of immunosuppressive T cell populations that mediate antigen-specific tolerance. In addition, we consider how related but distinct processes maintain tolerance to bacterial antigens in the large intestine. Finally, we outline the molecular mechanisms and functional consequences of failure of oral tolerance and how these may be modulated to enhance clinical outcomes and prevent disease.

Published
2024
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10. Enhanced cultured diversity of the mouse gut microbiota enables custom-made synthetic communities

Author

Afrizal, Afrizal, primary, Jennings, Susan A.V., additional, Hitch, Thomas C.A., additional, Riedel, Thomas, additional, Basic, Marijana, additional, Panyot, Atscharah, additional, Treichel, Nicole, additional, Hager, Fabian T., additional, Wong, Erin Oi-Yan, additional, Wolter, Birger, additional, Viehof, Alina, additional, von Strempel, Alexandra, additional, Eberl, Claudia, additional, Buhl, Eva M., additional, Abt, Birte, additional, Bleich, André, additional, Tolba, René, additional, Blank, Lars M., additional, Navarre, William W., additional, Kiessling, Fabian, additional, Horz, Hans-Peter, additional, Torow, Natalia, additional, Cerovic, Vuk, additional, Stecher, Bärbel, additional, Strowig, Till, additional, Overmann, Jörg, additional, and Clavel, Thomas, additional

Published
2022
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11. Stabilization but No Functional Influence of HIF-1α Expression in the Intestinal Epithelium during Salmonella Typhimurium Infection

Author

Robrahn, Laura, primary, Dupont, Aline, additional, Jumpertz, Sandra, additional, Zhang, Kaiyi, additional, Holland, Christian H., additional, Guillaume, Joël, additional, Rappold, Sabrina, additional, Roth, Johanna, additional, Cerovic, Vuk, additional, Saez-Rodriguez, Julio, additional, Hornef, Mathias W., additional, and Cramer, Thorsten, additional

Published
2022
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14. Intestinal-derived ILCs migrating in lymph increase IFNγ production in response to Salmonella Typhimurium infection

Author

Kästele, Verena, primary, Mayer, Johannes, additional, Lee, Edward S., additional, Papazian, Natalie, additional, Cole, John J., additional, Cerovic, Vuk, additional, Belz, Gabrielle, additional, Tomura, Michio, additional, Eberl, Gerard, additional, Goodyear, Carl, additional, Maciewicz, Rose A., additional, Wall, Daniel, additional, Cupedo, Tom, additional, Withers, David R., additional, and Milling, Simon, additional

Published
2021
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15. Conditional deletion of HIF-1α provides new insight regarding the murine response to gastrointestinal infection with Salmonella Typhimurium

Author

Robrahn, Laura, primary, Dupont, Aline, additional, Jumpertz, Sandra, additional, Zhang, Kaiyi, additional, Holland, Christian H., additional, Guillaume, Joël, additional, Rappold, Sabrina, additional, Cerovic, Vuk, additional, Saez-Rodriguez, Julio, additional, Hornef, Mathias W., additional, and Cramer, Thorsten, additional

Published
2021
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20. Intestinal-derived ILCs migrating in lymph increase IFNγ production in response to SalmonellaTyphimurium infection

Author

Kästele, Verena, Mayer, Johannes, Lee, Edward S., Papazian, Natalie, Cole, John J., Cerovic, Vuk, Belz, Gabrielle, Tomura, Michio, Eberl, Gerard, Goodyear, Carl, Maciewicz, Rose A., Wall, Daniel, Cupedo, Tom, Withers, David R., and Milling, Simon

Abstract

Innate lymphoid cells (ILCs) are enriched in mucosae and have been described as tissue-resident. Interestingly, ILCs are also present within lymph nodes (LNs), in the interfollicular regions, the destination for lymph-migratory cells. We have previously shown that LN ILCs are supplemented by peripheral tissue-derived ILCs. Using thoracic duct cannulations, we here enumerate the intestinal lymph ILCs that traffic from the intestine to the mesenteric LNs (MLNs). We provide, for the first time, a detailed characterisation of these lymph-migratory ILCs. We show that all ILC subsets migrate in lymph, and while global transcriptional analysis reveals a shared signature with tissue-resident ILCs, lymph ILCs express migration-associated genes including S1PRs, SELL(CD62L) and CCR7. Interestingly, we discovered that while SalmonellaTyphimurium infections do not increase the numbers of migrating ILCs, infection changes their composition and cytokine profile. Infection increases the proportions of RORyt+T-bet+ILCs, levels of IFNγ, and IFNγ/GM-CSF co-expression. Infection-induced changes in migratory ILCs are reflected in colon-draining MLN ILCs, where RORyt+T-bet+ILCs accumulate and display corresponding increased cytokine expression. Thus, we reveal that ILCs respond rapidly to intestinal infection and can migrate to the MLN where they produce cytokines.

Published
2021
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21. CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes

Author

Mackley, Emma C., Houston, Stephanie, Marriott, Clare L., Halford, Emily E., Lucas, Beth, Cerovic, Vuk, Filbey, Kara J., Maizels, Rick M., Hepworth, Matthew R., Sonnenberg, Gregory F., Milling, Simon, and Withers, David R.

Subjects
CD4-Positive T-Lymphocytes, Male, Mice, Inbred BALB C, Receptors, CCR7, Mucous Membrane, Light, Mice, Transgenic, Nuclear Receptor Subfamily 1, Group F, Member 3, Corrigenda, Immunity, Innate, Article, Intestines, Mice, Inbred C57BL, Mice, Microscopy, Fluorescence, Cell Movement, Animals, Female, Lymph Nodes, Lymphocytes, Intestinal Mucosa
Abstract

Presentation of peptide:MHCII by RORγ-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral lymph nodes. By photoconverting intestinal cells in Kaede mice we reveal constitutive trafficking of ILCs from the intestine to the draining mesenteric lymph nodes, which specifically for the LTi-like ILC3s was CCR7-dependent. Thus, ILC populations traffic to draining lymph nodes using different mechanisms., Innate lymphoid cells have an important role in mucosal immunity and present peptide:MHCII to CD4 T cells. Here the authors show that innate lymphoid cell subsets migrate from the gut mucosa to the draining lymph nodes via different mechanisms, where they form distinct microenvironments.

Published
2015

22. Interactions of the microbiota with the mucosal immune system.

Author

Bain, Calum C. and Cerovic, Vuk

Subjects
*IMMUNE system, *CLINICAL immunology, *IMMUNITY, *IMMUNOLOGY
Abstract

Summary: The field of mucosal immunology has, for the last 10 years, been largely dominated by advances in our understanding of the commensal microbiota. Developments of novel experimental methodologies and analysis techniques have provided unparalleled insight into the profound impact the microbiota has on the development and function of the immune system. In this cross‐journal review series published in Immunology and Clinical and Experimental Immunology, we aim to summarize the current state of research concerning the interplay between the microbiota and mucosal immunity. In addition, the series examines how the increased understanding of the microbiota is changing the nature of immunological research, both in the laboratory and in the clinic. [ABSTRACT FROM AUTHOR]

Published
2020
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25. CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.

Author

Mackley EC, Houston S, Marriott CL, Halford EE, Lucas B, Cerovic V, Filbey KJ, Maizels RM, Hepworth MR, Sonnenberg GF, Milling S, and Withers DR

Subjects
Animals, CD4-Positive T-Lymphocytes immunology, Cell Movement, Female, Immunity, Innate, Intestinal Mucosa metabolism, Intestines immunology, Light, Lymph Nodes pathology, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Fluorescence, Mucous Membrane pathology, Lymph Nodes cytology, Lymphocytes cytology, Mucous Membrane metabolism, Nuclear Receptor Subfamily 1, Group F, Member 3 metabolism, Receptors, CCR7 metabolism
Abstract

Presentation of peptide:MHCII by RORγ-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral lymph nodes. By photoconverting intestinal cells in Kaede mice we reveal constitutive trafficking of ILCs from the intestine to the draining mesenteric lymph nodes, which specifically for the LTi-like ILC3s was CCR7-dependent. Thus, ILC populations traffic to draining lymph nodes using different mechanisms.

Published
2015
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