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CCR7-dependent trafficking of RORĪ³+ ILCs creates a unique microenvironment within mucosal draining lymph nodes
- Source :
- Nature Communications
- Publication Year :
- 2015
- Publisher :
- Nature Publishing Group, 2015.
-
Abstract
- Presentation of peptide:MHCII by RORĪ³-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral lymph nodes. By photoconverting intestinal cells in Kaede mice we reveal constitutive trafficking of ILCs from the intestine to the draining mesenteric lymph nodes, which specifically for the LTi-like ILC3s was CCR7-dependent. Thus, ILC populations traffic to draining lymph nodes using different mechanisms.<br />Innate lymphoid cells have an important role in mucosal immunity and present peptide:MHCII to CD4 T cells. Here the authors show that innate lymphoid cell subsets migrate from the gut mucosa to the draining lymph nodes via different mechanisms, where they form distinct microenvironments.
- Subjects :
- CD4-Positive T-Lymphocytes
Male
Mice, Inbred BALB C
Receptors, CCR7
Mucous Membrane
Light
Mice, Transgenic
Nuclear Receptor Subfamily 1, Group F, Member 3
Corrigenda
Immunity, Innate
Article
Intestines
Mice, Inbred C57BL
Mice
Microscopy, Fluorescence
Cell Movement
Animals
Female
Lymph Nodes
Lymphocytes
Intestinal Mucosa
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.pmid.dedup....a07f875871f35ba0e847aee05cddd736