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Your search keyword '"Bullock, A. D."' showing total 149 results
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149 results on '"Bullock, A. D."'

2. Effects of protein restriction on insulin-like growth factor (IGF)-1 in men with prostate cancer: results from a randomized clinical trial.

Author

Cagigas, Maria L., Fiorito, Giovanni, Bertozzi, Beatrice, Masedunskas, Andrius, Cava, Edda, Spelta, Francesco, Veronese, Nicola, Tosti, Valeria, Rajakumar, Gayathiri, Pelaia, Tiana, Bullock, Arnold D., Figenshau, Robert S., Andriole, Gerald L., and Fontana, Luigi

Subjects
SOMATOMEDIN, PROSTATE cancer patients, CLINICAL trials, LEAN body mass, LOW-calorie diet
Abstract

Background: Insulin-like growth factor (IGF)-1 and its binding proteins are important in cancer growth, especially in prostate cancer. Observational studies suggest that protein restriction can lower IGF-1 levels. However, it is unclear whether an isocaloric protein-restricted diet affects IGF-1 and IGFBPs in men with prostate cancer. Methods: In this academic, single-center, parallel-group, prospective, randomized, open-label, blinded end-point trial, 38 consenting overweight (BMI 30.5 ± 5.5 kg/m2) men with localized prostate cancer, aged 43–72 years, were randomized (1:1) with permuted blocks to 4–6 weeks of customized isocaloric PR diets (0.8 g protein/kg lean body mass) or their usual diet. Biomarkers influencing cancer biology, including serum IGF-1 and its binding proteins were measured longitudinally. Results: Contrary to our hypothesis, feeding individuals an isocaloric protein-restricted diet did not result in a significant reduction in serum IGF-1. Moreover, there was no observed increase in serum IGFBP-1 or IGFBP-3 concentration. Conclusion: These findings demonstrate that protein restriction without calorie restriction does not reduce serum IGF-1 concentration or increase IGFBP-1 and IGFBP-3 in men with localized prostate cancer. Further research is needed to identify dietary interventions for safely and effectively reducing IGF-1 in this patient group. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Wavelength Dependence of Modal Bandwidth of Multimode Fibers for High Data Rate Transmission and Its Implications.

Author

Chen, Xin, Dong, Hao, Chen, Hao, Hurley, Jason E., Bullock, Zoren D., and Li, Ming-Jun

Subjects
SURFACE emitting lasers, MONTE Carlo method, OPTICAL dispersion, DATA transmission systems, BANDWIDTHS
Abstract

Vertical-cavity surface-emitting laser (VCSEL)-based transmission over multimode fiber (MMF) has achieved data rates of 100G per lane and is progressing towards 200G per lane. Recently, high-data-rate MMFs derived from OM3 and OM4 have been proposed. These fibers exhibit higher effective modal bandwidths at 910 nm, leading to a different wavelength dependence compared to conventional OM3 and OM4 MMFs. Understanding the wavelength dependence of these fibers is crucial to address their utilization in a broader range of applications. Through Monte Carlo simulations, we have obtained the low-end boundary of the effective modal bandwidths (EMBs) for these fibers, revealing capability improvements over the existing OM3 and OM4. The high-data-rate OM4 performs the same as or better than OM5 from 840 nm to 920 nm, while also showing a high bandwidth for the 850–870 nm wavelength window, favoring VCSELs with center wavelengths shifted toward 860 nm. We also obtained the link bandwidth, which includes both modal bandwidth and chromatic dispersion contributions, and the transmission reaches for various types of transceivers. We find that for both high-data-rate OM3 and high-data-rate OM4, the link bandwidth stays above the value at 850 nm until around 910 nm, delivering a similar transmission performance from 850 to 910 nm without declining towards longer wavelengths, unlike the standard OM3 and OM4. This characteristic favors a wider range of wavelength choices for VCSELs and enables optimal deployments for various applications. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Supplementary Figure 1 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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5. Supplementary Figure 5 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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6. Supplementary Figure 2 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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7. Supplementary Figure Legends from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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8. Data from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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9. Supplementary Figure 3 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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10. Supplementary Genes from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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11. Supplementary Table 1 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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12. Supplementary Table 2 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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13. Supplementary Materials and Methods from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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14. Supplementary Figure 4 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, primary, Jenei, Veronika, primary, Bullock, Marc D., primary, Bruce, Amanda, primary, Mitter, Richard, primary, Kelly, Gavin, primary, Paraskeva, Christos, primary, Strefford, John, primary, Primrose, John, primary, Thomas, Gareth J., primary, Packham, Graham, primary, and Mirnezami, Alex H., primary

Published
2023
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22. Editor's Note: miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance

Author

Zhang, Lei, primary, Pickard, Karen, additional, Jenei, Veronika, additional, Bullock, Marc D., additional, Bruce, Amanda, additional, Mitter, Richard, additional, Kelly, Gavin, additional, Paraskeva, Christos, additional, Strefford, John, additional, Primrose, John, additional, Thomas, Gareth J., additional, Packham, Graham, additional, and Mirnezami, Alex H., additional

Published
2022
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24. The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis

Author

Ling, Hui, Pickard, Karen, Ivan, Cristina, Isella, Claudio, Ikuo, Mariko, Mitter, Richard, Spizzo, Riccardo, Bullock, Marc D, Braicu, Cornelia, Pileczki, Valentina, Vincent, Kimberly, Pichler, Martin, Stiegelbauer, Verena, Hoefler, Gerald, Almeida, Maria I, Hsiao, Annie, Zhang, Xinna, Primrose, John N, Packham, Graham K, Liu, Kevin, Bojja, Krishna, Gafà, Roberta, Xiao, Lianchun, Rossi, Simona, Song, Jian H, Vannini, Ivan, Fanini, Francesca, Kopetz, Scott, Zweidler-McKay, Patrick, Wang, Xuemei, Ionescu, Calin, Irimie, Alexandru, Fabbri, Muller, Lanza, Giovanni, Hamilton, Stanley R, Berindan-Neagoe, Ioana, Medico, Enzo, Mirnezami, Alex H, Calin, George A, and Nicoloso, Milena S

Published
2016
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27. The significance of pretreatment anemia in the era of R-IPI and NCCN-IPI prognostic risk assessment tools: a dual-center study in diffuse large B-cell lymphoma patients

Author

Troppan, Katharina T., Melchardt, Thomas, Deutsch, Alexander, Schlick, Konstantin, Stojakovic, Tatjana, Bullock, Marc D., Reitz, Daniel, Beham-Schmid, Christine, Weiss, Lukas, Neureiter, Daniel, Wenzl, Kerstin, Greil, Richard, Neumeister, Peter, Egle, Alexander, and Pichler, Martin

Published
2015
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32. Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer

Author

Bhome, Rahul, Del Vecchio, Filippo, Lee, Gui-Han, Bullock, Marc D, Primrose, John N, Sayan, A Emre, and Mirnezami, Alex H

Subjects
MicroRNAs, microRNA, Neoplasms, Biomarkers, Tumor, exosome, cancer, biomarker, Humans, Precision Medicine, exomiR, Exosomes, Article
Abstract

Exosomes are secreted vesicles which can transmit molecular cargo between cells. Exosomal microRNAs (exomiRs) have drawn much attention in recent years because there is increasing evidence to suggest that loading of microRNAs into exosomes is not a random process. Preclinical studies have identified functional roles for exomiRs in influencing many hallmarks of cancer. Mechanisms underpinning their actions, such as exomiR receptors (“miRceptors”), are now becoming apparent. Even more exciting is the fact that exomiRs are highly suitable candidates for use as non-invasive biomarkers in an era of personalized cancer medicine., Highlights • MicroRNAs packaged and secreted in exosomes are termed “exomiRs”. • Sorting of miRNAs into exosomes is a selective process. • Cancer and stroma-derived exomiRs influence many hallmarks of cancer. • ExomiRs are highly promising cancer biomarkers.

Published
2018

33. A propensity analysis comparing definitive chemo-radiotherapy for muscle-invasive squamous cell carcinoma of the bladder vs. urothelial carcinoma of the bladder using the National Cancer Database

Author

Fischer-Valuck, Benjamin W., Michalski, Jeff M., Contreras, Jessika A., Brenneman, Randall, Christodouleas, John P., Abraham, Christopher D., Kim, Eric H., Arora, Vivek K., Bullock, Arnold D., Carmona, Ruben, Figenshau, Robert S., Grubb, Robert, III, Knoche, Eric M., Pachynski, Russell K., Picus, Joel, Roth, Bruce J., Sargos, Paul, Andriole, Gerald L., Gay, Hiram A., and Baumann, Brian C.

Published
2019
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37. Surgical Management for Prostate Cancer

Author

Kim, Eric H. and Bullock, Arnold D.

Subjects
Science of Medicine | Feature Series, Male, Prostatectomy, Humans, Prostatic Neoplasms, Prognosis
Abstract

For prostate cancer, radical prostatectomy remains the gold standard for surgical management. Given the side effects associated with surgery, patients at low risk of prostate cancer-specific mortality should consider active surveillance under the guidance of a urologist to safely delay intervention. For patients with an intermediate risk of cancer-specific mortality and otherwise healthy life expectancy, radical prostatectomy has been demonstrated to improve survival. Finally, even for select patients with advanced prostate cancer-metastatic disease to the lymph nodes or distant sites-radical prostatectomy may provide a survival benefit.

Published
2018

41. An evaluation of a new practice-based small group learning (PBSGL) initiative in Wales.

Author

Bartlett, S., Bullock, A. D., and Hodgson, K.

Subjects
*FOCUS groups, *WORK, *LEARNING strategies, *PRIMARY health care, *EXPERIENTIAL learning, *INTERDISCIPLINARY education, *THEMATIC analysis
Abstract

In 2018, a new practice-based small group learning (PBSGL) pilot initiative was launched in Wales to promote interprofessional learning among different primary care professionals. The aim of this study was to evaluate the initiative in order to identify its strengths and areas for improvement. Data were collected through focus groups with PBSGL groups in Wales and analysed thematically. Participants generally held positive views of PBSGL and were impressed with the variety and overall relevance of the learning materials, although concern was raised about the relevance of all learning materials to the Welsh context. The interprofessional component was valued for reducing feelings of isolation and all participants were able to contribute to discussions, an outcome helped by existing relationships among group members. Many participants reflected on occasions where they had made changes to their practice as a result of PBSGL activity. Time and funding were cited as potential barriers to continuing participation in PBSGL and there is scope to tailor material more to the context of the healthcare system in Wales. [ABSTRACT FROM AUTHOR]

Published
2021
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42. Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5–dependent and –independent mechanisms

Author

Treviño-Villarreal, J. Humberto, primary, Reynolds, Justin S., additional, Bartelt, Alexander, additional, Langston, P. Kent, additional, MacArthur, Michael R., additional, Arduini, Alessandro, additional, Tosti, Valeria, additional, Veronese, Nicola, additional, Bertozzi, Beatrice, additional, Brace, Lear E., additional, Mejia, Pedro, additional, Trocha, Kaspar, additional, Kajitani, Gustavo S., additional, Longchamp, Alban, additional, Harputlugil, Eylul, additional, Gathungu, Rose, additional, Bird, Susan S., additional, Bullock, Arnold D., additional, Figenshau, Robert S., additional, Andriole, Gerald L., additional, Thompson, Andrew, additional, Heeren, Jöerg, additional, Ozaki, C. Keith, additional, Kristal, Bruce S., additional, Fontana, Luigi, additional, and Mitchell, James R., additional

Published
2018
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45. Exosomal microRNAs derived from colorectal cancer-associated fibroblasts: role in driving cancer progression

Author

Bhome, Rahul, primary, Goh, Rebecca W., additional, Bullock, Marc D., additional, Pillar, Nir, additional, Thirdborough, Stephen M., additional, Mellone, Massimiliano, additional, Mirnezami, Reza, additional, Galea, Dieter, additional, Veselkov, Kirill, additional, Gu, Quan, additional, Underwood, Timothy J., additional, Primrose, John N., additional, De Wever, Olivier, additional, Shomron, Noam, additional, Sayan, A. Emre, additional, and Mirnezami, Alex H., additional

Published
2017
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