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Effects of protein restriction on insulin-like growth factor (IGF)-1 in men with prostate cancer: results from a randomized clinical trial.
- Source :
- Biomarker Research; 7/22/2024, Vol. 12 Issue 1, p1-4, 4p
- Publication Year :
- 2024
-
Abstract
- Background: Insulin-like growth factor (IGF)-1 and its binding proteins are important in cancer growth, especially in prostate cancer. Observational studies suggest that protein restriction can lower IGF-1 levels. However, it is unclear whether an isocaloric protein-restricted diet affects IGF-1 and IGFBPs in men with prostate cancer. Methods: In this academic, single-center, parallel-group, prospective, randomized, open-label, blinded end-point trial, 38 consenting overweight (BMI 30.5 ± 5.5 kg/m<superscript>2</superscript>) men with localized prostate cancer, aged 43–72 years, were randomized (1:1) with permuted blocks to 4–6 weeks of customized isocaloric PR diets (0.8 g protein/kg lean body mass) or their usual diet. Biomarkers influencing cancer biology, including serum IGF-1 and its binding proteins were measured longitudinally. Results: Contrary to our hypothesis, feeding individuals an isocaloric protein-restricted diet did not result in a significant reduction in serum IGF-1. Moreover, there was no observed increase in serum IGFBP-1 or IGFBP-3 concentration. Conclusion: These findings demonstrate that protein restriction without calorie restriction does not reduce serum IGF-1 concentration or increase IGFBP-1 and IGFBP-3 in men with localized prostate cancer. Further research is needed to identify dietary interventions for safely and effectively reducing IGF-1 in this patient group. [ABSTRACT FROM AUTHOR]
- Subjects :
- SOMATOMEDIN
PROSTATE cancer patients
CLINICAL trials
LEAN body mass
LOW-calorie diet
Subjects
Details
- Language :
- English
- ISSN :
- 20507771
- Volume :
- 12
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Biomarker Research
- Publication Type :
- Academic Journal
- Accession number :
- 178589028
- Full Text :
- https://doi.org/10.1186/s40364-024-00613-w