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182 results on '"Blaha, Charles D."'

6. Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine

Author

Varela, Roger B., primary, Boschen, Suelen L., additional, Yates, Nathanael, additional, Houghton, Tristan, additional, Blaha, Charles D., additional, Lee, Kendall H., additional, Bennet, Kevin E., additional, Kouzani, Abbas Z., additional, Berk, Michael, additional, Quevedo, João, additional, Valvassori, Samira S., additional, and Tye, Susannah J., additional

Published
2024
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9. Advances in neurochemical measurements: A review of biomarkers and devices for the development of closed-loop deep brain stimulation systems

Author

Rojas Cabrera Juan M., Blair Price J., Rusheen Aaron E., Goyal Abhinav, Jondal Danielle, Barath Abhijeet S., Shin Hojin, Chang Su-Youne, Bennet Kevin E., Blaha Charles D., Lee Kendall H., and Oh Yoonbae

Subjects
deep brain stimulation, neuromodulation, electrochemistry, electrophysiology, closed-loop, voltammetry, Chemistry, QD1-999
Abstract

Neurochemical recording techniques have expanded our understanding of the pathophysiology of neurological disorders, as well as the mechanisms of action of treatment modalities like deep brain stimulation (DBS). DBS is used to treat diseases such as Parkinson’s disease, Tourette syndrome, and obsessive-compulsive disorder, among others. Although DBS is effective at alleviating symptoms related to these diseases and improving the quality of life of these patients, the mechanism of action of DBS is currently not fully understood. A leading hypothesis is that DBS modulates the electrical field potential by modifying neuronal firing frequencies to non-pathological rates thus providing therapeutic relief. To address this gap in knowledge, recent advances in electrochemical sensing techniques have given insight into the importance of neurotransmitters, such as dopamine, serotonin, glutamate, and adenosine, in disease pathophysiology. These studies have also highlighted their potential use in tandem with electrophysiology to serve as biomarkers in disease diagnosis and progression monitoring, as well as characterize response to treatment. Here, we provide an overview of disease-relevant neurotransmitters and their roles and implications as biomarkers, as well as innovations to the biosensors used to record these biomarkers. Furthermore, we discuss currently available neurochemical and electrophysiological recording devices, and discuss their viability to be implemented into the development of a closed-loop DBS system.

Published
2020
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11. Techniques for Measurement of Serotonin: Implications in Neuropsychiatric Disorders and Advances in Absolute Value Recording Methods

Author

Rojas Cabrera, Juan M., primary, Oesterle, Tyler S., additional, Rusheen, Aaron E., additional, Goyal, Abhinav, additional, Scheitler, Kristen M., additional, Mandybur, Ian, additional, Blaha, Charles D., additional, Bennet, Kevin E., additional, Heien, Michael L., additional, Jang, Dong Pyo, additional, Lee, Kendall H., additional, Oh, Yoonbae, additional, and Shin, Hojin, additional

Published
2023
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14. The development of ultra–high field MRI guidance technology for neuronavigation

Author

Rusheen, Aaron E., Goyal, Abhinav, Owen, Robert L., Berning, Elise M., Bothun, Dane T., Giblon, Rachel E., Blaha, Charles D., Welker, Kirk M., Huston, John, Bennet, Kevin E., Oh, Yoonbae, Fagan, Andrew J., and Lee, Kendall H.

Subjects
Laboratory Investigation, General Medicine
Abstract

OBJECTIVE Magnetic resonance imaging at 7T offers improved image spatial and contrast resolution for visualization of small brain nuclei targeted in neuromodulation. However, greater image geometric distortion and a lack of compatible instrumentation preclude implementation. In this report, the authors detail the development of a stereotactic image localizer and accompanying imaging sequences designed to mitigate geometric distortion, enabling accurate image registration and surgical planning of basal ganglia nuclei. METHODS Magnetization-prepared rapid acquisition with gradient echo (MPRAGE), fast gray matter acquisition T1 inversion recovery (FGATIR), T2-weighted, and T2*-weighted sequences were optimized for 7T in 9 human subjects to visualize basal ganglia nuclei, minimize image distortion, and maximize target contrast-to-noise and signal-to-noise ratios. Extracranial spatial distortions were mapped to develop a skull-contoured image localizer embedded with spherical silicone fiducials for improved MR image registration and target guidance. Surgical plan accuracy testing was initially performed in a custom-developed MRI phantom (n = 5 phantom studies) and finally in a human trial. RESULTS MPRAGE and T2*-weighted sequences had the best measures among global measures of image quality (3.8/4, p < 0.0001; and 3.7/4, p = 0.0002, respectively). Among basal ganglia nuclei, FGATIR outperformed MPRAGE for globus pallidus externus (GPe) visualization (2.67/4 vs 1.78/4, p = 0.008), and FGATIR, T2-weighted imaging, and T2*-weighted imaging outperformed MPRAGE for substantia nigra visualization (1.44/4 vs 2.56/4, p = 0.04; vs 2.56/4, p = 0.04; vs 2.67/4, p = 0.003). Extracranial distortion was lower in the head’s midregion compared with the base and apex ( 1.17–1.33 mm; MPRAGE and FGATIR, p < 0.0001; T2-weighted imaging, p > 0.05; and T2*-weighted imaging, p = 0.013). Fiducial placement on the localizer in low distortion areas improved image registration (fiducial registration error, 0.79–1.19 mm; p < 0.0001) and targeting accuracy (target registration error, 0.60–1.09 mm; p = 0.04). Custom surgical software and the refined image localizer enabled successful surgical planning in a human trial (fiducial registration error = 1.0 mm). CONCLUSIONS A skull-contoured image localizer that accounts for image distortion is necessary to enable high-accuracy 7T imaging–guided targeting for surgical neuromodulation. These results may enable improved clinical efficacy for the treatment of neurological disease.

Published
2022
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16. Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation

Author

Yuen, Jason, primary, Goyal, Abhinav, additional, Rusheen, Aaron E., additional, Kouzani, Abbas Z., additional, Berk, Michael, additional, Kim, Jee Hyun, additional, Tye, Susannah J., additional, Abulseoud, Osama A., additional, Oesterle, Tyler S., additional, Blaha, Charles D., additional, Bennet, Kevin E., additional, Lee, Kendall H., additional, Oh, Yoonbae, additional, and Shin, Hojin, additional

Published
2023
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19. List of Contributors of Volume 1

Author

Ackermann, D. Michael, primary, Ajiboye, Abidemi B., additional, Allison, Brendan Z., additional, Barolat, Giancarlo, additional, Bhadra, Narendra, additional, Bhadra, Niloy, additional, Blaha, Charles D., additional, Bouton, Chad E., additional, Bradley, Kerry, additional, Capadona, Jeffrey R., additional, Cogan, Stuart F., additional, Cozzens, Jeffrey W., additional, Cusack, William, additional, D’Haese, Pierre-Francois, additional, Dawant, Benoit M., additional, de Groat, William C., additional, De Ridder, Dirk, additional, Denison, Timothy, additional, Dolce, Jeffery J., additional, Doleys, Daniel M., additional, Donoghue, John P., additional, E. Larsen, Lars, additional, Falowski, Steven M., additional, Foster, Allison, additional, Gauthier, Lynne V., additional, George, Lydia C., additional, Gomez, Christy, additional, Goodman, Amy M., additional, Grill, Warren M., additional, Gross, Robert E., additional, Guan, Yun, additional, Hara, Seth, additional, Harris, James, additional, He, Bin, additional, Herron, Jeffrey A., additional, Hoyen, Harry A., additional, Kaplitt, Michael G., additional, Keith, Michael W., additional, Kent, Alexander R., additional, Kilgore, Kevin L., additional, Kirsch, Robert F., additional, Kocharian, Gary, additional, Konrad, Peter E., additional, Kramer, Jeffery, additional, Krames, Elliot S., additional, Krishna, Vibhor, additional, Lee, Kendall H., additional, Linderoth, Bengt, additional, Ludwig, Kip A., additional, Machado, Andre G., additional, Madineni, Ravichandra, additional, Manker, Steve G., additional, McIntyre, Cameron C., additional, Mogilner, Alon Y., additional, Mortimer, John T., additional, Mosier, Elizabeth M., additional, North, Richard B., additional, Pancrazio, Joseph J., additional, Parker, John L., additional, Peckham, P. Hunter, additional, Pedersen, Nigel P., additional, Peterson, Erik J., additional, Pless, Benjamin, additional, Pulliam, Christopher L., additional, Rezai, Ali R., additional, Richter, Troy A., additional, Riley, Jonathan, additional, Rosenow, Joshua M., additional, Ross, Erika, additional, Sammartino, Francesco, additional, Schalk, Gerwin, additional, Schubauer, Kathryn M., additional, Sharan, Ashwini D., additional, Shellock, Frank G., additional, Shipley, Jane, additional, Shoffstall, Andrew, additional, Simpson, Brian, additional, Slavin, Konstantin V., additional, Stanton-Hicks, Michael, additional, Tai, Changfeng, additional, Taylor, Toacca, additional, Tomasiewicz, Hilarie C., additional, Tyler, Dustin J., additional, Vancamp, Tim, additional, Vanneste, Sven, additional, Vonck, Kristl E.J., additional, W. Clark, Shannon, additional, Weber, Doug, additional, Weiner, Richard L., additional, Wolfson, Michael, additional, Wu, Chengyuan, additional, Ye, Donald Y., additional, Yin, Dali, additional, and Yin, Hang, additional

Published
2018
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20. Improved circuitry and post-processing for interleaved fast-scan cyclic voltammetry and electrophysiology measurements.

Author

Avula, Ashwin K., Goyal, Abhinav, Rusheen, Aaron E., Yuen, Jason, Dennis, Warren O., Eaker, Diane R., Boesche, Joshua B., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Hojin Shin, and Yoonbae Oh

Subjects
COMPLEMENTARY metal oxide semiconductors, ELECTROPHYSIOLOGY, CHARGE injection, OPERATIONAL amplifiers, HIGHPASS electric filters
Abstract

The combination of electrophysiology and electrochemistry acquisition methods using a single carbon fiber microelectrode (CFM) in the brain has enabled more extensive analysis of neurochemical release, neural activity, and animal behavior. Predominantly, analog CMOS (Complementary Metal Oxide Semiconductor) switches are used for these interleaved applications to alternate the CFM output between electrophysiology and electrochemistry acquisition circuitry. However, one underlying issue with analog CMOS switches is the introduction of transient voltage artifacts in recorded electrophysiology signals resulting from CMOS charge injection. These injected artifacts attenuate electrophysiology data and delay reliable signal observation after every switch actuation from electrochemistry acquisition. Previously published attempts at interleaved electrophysiology and electrochemistry were able to recover reliable electrophysiology data within approximately 10-50 ms after switch actuation by employing various high-pass filtering methods to mitigate the observed voltage artifacts. However, high-pass filtering of this nature also attenuates valuable portions of the local-field potential (LFP) frequency range, thus limiting the extent of network-level insights that can be derived from in vivo measurements. This paper proposes a solution to overcome the limitation of charge injection artifacts that affect electrophysiological data while preserving important lower-frequency LFP bands. A voltage follower operational amplifier was integrated before the CMOS switch to increase current flow to the switch and dissipate any injected charge. This hardware addition resulted in a 16.98% decrease in electrophysiology acquisition delay compared to circuitry without a voltage follower. Additionally, single-term exponential modeling was implemented in post-processing to characterize and subtract remaining transient voltage artifacts in recorded electrophysiology data. As a result, electrophysiology data was reliably recovered 3.26 ± 0.22 ms after the beginning of the acquisition period (a 60% decrease from previous studies), while also minimizing LFP attenuation. Through these advancements, coupled electrophysiology and electrochemistry measurements can be conducted at higher scan rates while retaining data integrity for a more comprehensive analysis of neural activity and neurochemical release. [ABSTRACT FROM AUTHOR]

Published
2023
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21. High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens

Author

Yuen, Jason, primary, Goyal, Abhinav, additional, Rusheen, Aaron E., additional, Kouzani, Abbas Z., additional, Berk, Michael, additional, Kim, Jee Hyun, additional, Tye, Susannah J., additional, Blaha, Charles D., additional, Bennet, Kevin E., additional, Lee, Kendall H., additional, Shin, Hojin, additional, and Oh, Yoonbae, additional

Published
2023
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35. Tonic Serotonin Measurements In Vivo Using N-Shaped Multiple Cyclic Square Wave Voltammetry

Author

Shin, Hojin, primary, Goyal, Abhinav, additional, Barnett, J. Hudson, additional, Rusheen, Aaron E., additional, Yuen, Jason, additional, Jha, Rohan, additional, Hwang, Sang Mun, additional, Kang, Yumin, additional, Park, Cheonho, additional, Cho, Hyun-U, additional, Blaha, Charles D., additional, Bennet, Kevin E., additional, Oh, Yoonbae, additional, Heien, Michael L., additional, Jang, Dong Pyo, additional, and Lee, Kendall H., additional

Published
2021
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36. Feasibility of Applying Fourier Transform Electrochemical Impedance Spectroscopy in Fast Cyclic Square Wave Voltammetry for the In Vivo Measurement of Neurotransmitters

Author

Park, Cheonho, primary, Hwang, Sangmun, additional, Kang, Yumin, additional, Sim, Jeongeun, additional, Cho, Hyun U., additional, Oh, Yoonbae, additional, Shin, Hojin, additional, Kim, Do Hyoung, additional, Blaha, Charles D., additional, Bennet, Kevin E., additional, Lee, Kendall H., additional, and Jang, Dong Pyo, additional

Published
2021
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38. Cocaine-Induced Changes in Tonic Dopamine Concentrations Measured Using Multiple-Cyclic Square Wave Voltammetry in vivo

Author

Yuen, Jason, primary, Goyal, Abhinav, additional, Rusheen, Aaron E., additional, Kouzani, Abbas Z., additional, Berk, Michael, additional, Kim, Jee Hyun, additional, Tye, Susannah J., additional, Blaha, Charles D., additional, Bennet, Kevin E., additional, Jang, Dong-Pyo, additional, Lee, Kendall H., additional, Shin, Hojin, additional, and Oh, Yoonbae, additional

Published
2021
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39. Automatic and Reliable Quantification of Tonic Dopamine Concentrations In Vivo Using a Novel Probabilistic Inference Method

Author

Kim, Jaekyung, primary, Barath, Abhijeet S., additional, Rusheen, Aaron E., additional, Rojas Cabrera, Juan M., additional, Price, J. Blair, additional, Shin, Hojin, additional, Goyal, Abhinav, additional, Yuen, Jason W., additional, Jondal, Danielle E., additional, Blaha, Charles D., additional, Lee, Kendall H., additional, Jang, Dong Pyo, additional, and Oh, Yoonbae, additional

Published
2021
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46. Global network modulation during thalamic stimulation for Tourette syndrome

Author

Jo, Hang Joon, McCairn, Kevin W., Gibson, William S., Testini, Paola, Zhao, Cong Zhi, Gorny, Krzysztof R., Felmlee, Joel P., Welker, Kirk M., Blaha, Charles D., Klassen, Bryan T., Min, Hoon-Ki, Lee, Kendall H., Jo, Hang Joon, McCairn, Kevin W., Gibson, William S., Testini, Paola, Zhao, Cong Zhi, Gorny, Krzysztof R., Felmlee, Joel P., Welker, Kirk M., Blaha, Charles D., Klassen, Bryan T., Min, Hoon-Ki, and Lee, Kendall H.

Abstract

Background and objectives: Deep brain stimulation (DBS) of the thalamus is a promising therapeutic alternative for treating medically refractory Tourette syndrome (TS). However, few human studies have examined its mechanism of action. Therefore, the networks that mediate the therapeutic effects of thalamic DBS remain poorly understood., Methods: Five participants diagnosed with severe medically refractory TS underwent bilateral thalamic DBS stereotactic surgery. Intraoperative fMRI characterized the blood oxygen level-dependent (BOLD) response evoked by thalamic DBS and determined whether the therapeutic effectiveness of thalamic DBS, as assessed using the Modified Rush Video Rating Scale test, would correlate with evoked BOLD responses in motor and limbic cortical and subcortical regions., Results: Our results reveal that thalamic stimulation in TS participants has wide-ranging effects that impact the frontostriatal, limbic, and motor networks. Thalamic stimulation induced suppression of motor and insula networks correlated with motor tic reduction, while suppression of frontal and parietal networks correlated with vocal tic reduction. These regions mapped closely to major regions of interest (ROI) identified in a nonhuman primate model of TS., Conclusions: Overall, these findings suggest that a critical factor in TS treatment should involve modulation of both frontostriatal and motor networks, rather than be treated as a focal disorder of the brain. Using the novel combination of DBS-evoked tic reduction and fMRI in human subjects, we provide new insights into the basal ganglia-cerebellar-thalamo-cortical network-level mechanisms that influence the effects of thalamic DBS. Future translational research should identify whether these network changes are cause or effect of TS symptoms.

Published
2018

47. Tonic Serotonin Measurements In VivoUsing N-Shaped Multiple Cyclic Square Wave Voltammetry

Author

Shin, Hojin, Goyal, Abhinav, Barnett, J. Hudson, Rusheen, Aaron E., Yuen, Jason, Jha, Rohan, Hwang, Sang Mun, Kang, Yumin, Park, Cheonho, Cho, Hyun-U, Blaha, Charles D., Bennet, Kevin E., Oh, Yoonbae, Heien, Michael L., Jang, Dong Pyo, and Lee, Kendall H.

Abstract

Here, we present the development of a novel voltammetric technique, N-shaped multiple cyclic square wave voltammetry (N-MCSWV) and its application in vivo. It allows quantitative measurements of tonic extracellular levels of serotonin in vivowith mitigated fouling effects. N-MCSWV enriches the electrochemical information by generating high dimensional voltammograms, which enables high sensitivity and selectivity against 5-hydroindoleacetic acid (5-HIAA), dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), histamine, ascorbic acid, norepinephrine, adenosine, and pH. Using N-MCSWV, in combination with PEDOT:Nafion-coated carbon fiber microelectrodes, a tonic serotonin concentration of 52 ± 5.8 nM (n= 20 rats, ±SEM) was determined in the substantia nigra pars reticulata of urethane-anesthetized rats. Pharmacological challenges with dopaminergic, noradrenergic, and serotonergic synaptic reuptake inhibitors supported the ability of N-MCSWV to selectively detect tonic serotonin levels in vivo. Overall, N-MCSWV is a novel voltammetric technique for analytical quantification of serotonin. It offers continuous monitoring of changes in tonic serotonin concentrations in the brain to further our understanding of the role of serotonin in normal behaviors and psychiatric disorders.

Published
2021
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48. Feasibility of Applying Fourier Transform Electrochemical Impedance Spectroscopy in Fast Cyclic Square Wave Voltammetry for the In VivoMeasurement of Neurotransmitters

Author

Park, Cheonho, Hwang, Sangmun, Kang, Yumin, Sim, Jeongeun, Cho, Hyun U., Oh, Yoonbae, Shin, Hojin, Kim, Do Hyoung, Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., and Jang, Dong Pyo

Abstract

We previously reported on the use of fast cyclic square wave voltammetry (FCSWV) as a new voltammetric technique. Fourier transform electrochemical impedance spectroscopy (FTEIS) has recently been utilized to provide information that enables a detailed analytical description of an electrified interface. In this study, we report on attempts to combine FTEIS with FCSWV (FTEIS–FCSWV) and demonstrate the feasibility of FTEIS–FCSWV in the in vivodetection of neurotransmitters, thus giving a new type of electrochemical impedance information such as biofouling on the electrode surface. From FTEIS–FCSWV, three new equivalent circuit element voltammograms, consisting of charge-transfer resistance (Rct), solution-resistance (Rs), and double-layer capacitance (Cdl) voltammograms were constructed and investigated in the phasic changes in dopamine (DA) concentrations. As a result, all Rct, Rs, and Cdlvoltammograms showed different DA redox patterns and linear trends for the DA concentration (R2> 0.99). Furthermore, the Rctvoltammogram in FTEIS–FCSWV showed lower limit of detection (21.6 ± 15.8 nM) than FSCV (35.8 ± 17.4 nM). FTEIS–FCSWV also showed significantly lower prediction errors than FSCV in selectivity evaluations of unknown mixtures of catecholamines. Finally, Cdlfrom FTEIS–FCSWV showed a significant relationship with fouling effect on the electrode surface by showing decreased DA sensitivity in both flow injection analysis experiment (r= 0.986) and in vivoexperiments. Overall, this study demonstrates the feasibility of FTEIS–FCSWV, which could offer a new type of neurochemical spectroscopic information concerning electrochemical monitoring of neurotransmitters in the brain, and the ability to estimate the degree of sensitivity loss caused by biofouling on the electrode surface.

Published
2021
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49. Cover Image

Author

Batton, Aiyana D., primary, Blaha, Charles D., additional, Bieber, Allan, additional, Lee, Kendall H., additional, and Boschen, Suelen L., additional

Published
2018
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50. Fast Cyclic Square-Wave Voltammetry To Enhance Neurotransmitter Selectivity and Sensitivity

Author

Park, Cheonho, primary, Oh, Yoonbae, additional, Shin, Hojin, additional, Kim, Jaekyung, additional, Kang, Yumin, additional, Sim, Jeongeun, additional, Cho, Hyun U., additional, Lee, Han Kyu, additional, Jung, Sung Jun, additional, Blaha, Charles D., additional, Bennet, Kevin E., additional, Heien, Michael L., additional, Lee, Kendall H., additional, Kim, In Young, additional, and Jang, Dong Pyo, additional

Published
2018
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