120 results on '"Beer, Juerg H."'
Search Results
2. Prevalence and outcomes of heart failure phenotypes in patients with atrial fibrillation
- Author
-
Tersalvi, Gregorio, Bossard, Matthias, Aeschbacher, Stefanie, Wiencierz, Andrea, Beer, Jürg H., Rodondi, Nicolas, Gencer, Baris F., Reichlin, Tobias, Auricchio, Angelo, Ammann, Peter, Moschovitis, Giorgio, Bonati, Leo, Osswald, Stefan, Kühne, Michael, Conen, David, and Kobza, Richard
- Published
- 2024
- Full Text
- View/download PDF
3. Hutchinson-Gilford progeria syndrome mice display accelerated arterial thrombus formation and increased platelet reactivity
- Author
-
Puspitasari, Yustina M., Ministrini, Stefano, Han, Jiaying, Karch, Caroline, Prisco, Francesco, Liberale, Luca, Bengs, Susan, Akhmedov, Alexander, Montecucco, Fabrizio, Beer, Jürg H., Lüscher, Thomas F., Bongiovanni, Dario, and Camici, Giovanni G.
- Published
- 2024
- Full Text
- View/download PDF
4. Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01
- Author
-
Weiner, January, Suwalski, Phillip, Holtgrewe, Manuel, Rakitko, Alexander, Thibeault, Charlotte, Müller, Melina, Patriki, Dimitri, Quedenau, Claudia, Krüger, Ulrike, Ilinsky, Valery, Popov, Iaroslav, Balnis, Joseph, Jaitovich, Ariel, Helbig, Elisa T, Lippert, Lena J, Stubbemann, Paula, Real, Luis M, Macías, Juan, Pineda, Juan A, Fernandez-Fuertes, Marta, Wang, Xiaomin, Karadeniz, Zehra, Saccomanno, Jacopo, Doehn, Jan-Moritz, Hübner, Ralf-Harto, Hinzmann, Bernd, Salvo, Mauricio, Blueher, Anja, Siemann, Sandra, Jurisic, Stjepan, Beer, Juerg H, Rutishauser, Jonas, Wiggli, Benedikt, Schmid, Hansruedi, Danninger, Kathrin, Binder, Ronald, Corman, Victor M, Mühlemann, Barbara, Arkal, Rao Arjun, Fragiadakis, Gabriela K, Mick, Eran, COMET, Consortium, Calfee, Carolyn S, Erle, David J, Hendrickson, Carolyn M, Kangelaris, Kirsten N, Krummel, Matthew F, Woodruff, Prescott G, Langelier, Charles R, Venkataramani, Urmila, García, Federico, Zyla, Joanna, Drosten, Christian, Alice, Braun, Jones, Terry C, Suttorp, Norbert, Witzenrath, Martin, Hippenstiel, Stefan, Zemojtel, Tomasz, Skurk, Carsten, Poller, Wolfgang, Borodina, Tatiana, Pa-COVID, Study Group, Ripke, Stephan, Sander, Leif E, Beule, Dieter, Landmesser, Ulf, Guettouche, Toumy, Kurth, Florian, and Heidecker, Bettina
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Coronaviruses ,Emerging Infectious Diseases ,Human Genome ,Clinical Research ,Infectious Diseases ,Genetics ,2.1 Biological and endogenous factors ,2.5 Research design and methodologies (aetiology) ,Good Health and Well Being ,SARS-CoV-2 ,COVID-19 ,Human Leukocyte Antigen  ,intubation ,Human Leukocyte Antigen ,Clinical sciences ,Health services and systems ,Public health - Abstract
BackgroundSince the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there has been increasing urgency to identify pathophysiological characteristics leading to severe clinical course in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human leukocyte antigen alleles (HLA) have been suggested as potential genetic host factors that affect individual immune response to SARS-CoV-2. We sought to evaluate this hypothesis by conducting a multicenter study using HLA sequencing.MethodsWe analyzed the association between COVID-19 severity and HLAs in 435 individuals from Germany (n = 135), Spain (n = 133), Switzerland (n = 20) and the United States (n = 147), who had been enrolled from March 2020 to August 2020. This study included patients older than 18 years, diagnosed with COVID-19 and representing the full spectrum of the disease. Finally, we tested our results by meta-analysing data from prior genome-wide association studies (GWAS).FindingsWe describe a potential association of HLA-C*04:01 with severe clinical course of COVID-19. Carriers of HLA-C*04:01 had twice the risk of intubation when infected with SARS-CoV-2 (risk ratio 1.5 [95% CI 1.1-2.1], odds ratio 3.5 [95% CI 1.9-6.6], adjusted p-value = 0.0074). These findings are based on data from four countries and corroborated by independent results from GWAS. Our findings are biologically plausible, as HLA-C*04:01 has fewer predicted bindings sites for relevant SARS-CoV-2 peptides compared to other HLA alleles.InterpretationHLA-C*04:01 carrier state is associated with severe clinical course in SARS-CoV-2. Our findings suggest that HLA class I alleles have a relevant role in immune defense against SARS-CoV-2.FundingFunded by Roche Sequencing Solutions, Inc.
- Published
- 2021
5. Real-World Cost-Effectiveness of Pulmonary Vein Isolation for Atrial Fibrillation: A Target Trial Approach
- Author
-
Serra-Burriel, Miquel, Aebersold, Helena, Foster-Witassek, Fabienne, Coslovsky, Michael, Rodondi, Nicolas, Blum, Manuel R., Sticherling, Christian, Moschovitis, Giorgio, Beer, Jürg H., Reichlin, Tobias, Krisai, Philipp, Aeschbacher, Stefanie, Paladini, Rebecca E., Kühne, Michael, Osswald, Stefan, Conen, David, Felder, Stefan, and Schwenkglenks, Matthias
- Published
- 2023
- Full Text
- View/download PDF
6. Intravenously administered APAC, a dual AntiPlatelet AntiCoagulant, targets arterial injury site to inhibit platelet thrombus formation and tissue factor activity in mice
- Author
-
Bonetti, Nicole R., Jouppila, Annukka S., Saeedi Saravi, Seyed Soheil, Cooley, Brian C., Pasterk, Lisa, Liberale, Luca L., Gobbato, Sara, Lüscher, Thomas F., Camici, Giovanni G., Lassila, Riitta P., and Beer, Jürg H.
- Published
- 2023
- Full Text
- View/download PDF
7. Long-term dietary n3 fatty acid prevents aging-related cardiac diastolic and vascular dysfunction
- Author
-
Saeedi Saravi, Seyed Soheil, Bonetti, Nicole R., Vukolic, Ana, Vdovenko, Daria, Lee, Pratintip, Liberale, Luca, Basso, Cristina, Rizzo, Stefania, Akhmedov, Alexander, Lüscher, Thomas F., Camici, Giovanni G., and Beer, Jürg H.
- Published
- 2023
- Full Text
- View/download PDF
8. Abstract 13364: Transplantation of Mutant Clostridium_ASF356 Rescues Aging Gut-Derived Phenylacetate-Mediated Perivascular Adipose Tissue and Endothelial Senescence
- Author
-
Pugin, Benoit, Constancias, Florentin, Thomas, Aurélien, LeGludic, Sylvain, Allemann, Meret S, Lee, Pratintip, Menni, Cristina, Paneni, Francesco, RUSCHITZKA, FRANK, Beer, Juerg H, and Saeedi Saravi, Seyed Soheil
- Published
- 2023
- Full Text
- View/download PDF
9. Xylitol: bitter cardiovascular data for a successful sweetener
- Author
-
Beer, Juerg H, primary and Allemann, Meret, additional
- Published
- 2024
- Full Text
- View/download PDF
10. Prevalence and risk of inappropriate dosing of direct oral anticoagulants in two Swiss atrial fibrillation registries
- Author
-
Montrasio, Giulia, Reiner, Martin F., Wiencierz, Andrea, Aeschbacher, Stefanie, Baumgartner, Christine, Rodondi, Nicolas, Kühne, Michael, Moschovitis, Giorgio, Preiss, Helga, Coslovsky, Michael, De Perna, Maria L., Bonati, Leo H., Conen, David, Osswald, Stefan, Beer, Juerg H., and Koepfli, Pascal
- Published
- 2022
- Full Text
- View/download PDF
11. Dietary alpha‐linolenic acid reduces platelet activation and collagen‐mediated cell adhesion in sickle cell disease mice
- Author
-
Stivala, Simona, Gobbato, Sara, Bonetti, Nicole, Camici, Giovanni G., Lüscher, Thomas F., and Beer, Jürg H.
- Published
- 2022
- Full Text
- View/download PDF
12. Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01
- Author
-
Weiner, January, 3rd, Suwalski, Phillip, Holtgrewe, Manuel, Rakitko, Alexander, Thibeault, Charlotte, Müller, Melina, Patriki, Dimitri, Quedenau, Claudia, Krüger, Ulrike, Ilinsky, Valery, Popov, Iaroslav, Balnis, Joseph, Jaitovich, Ariel, Helbig, Elisa T, Lippert, Lena J, Stubbemann, Paula, Real, Luis M, Macías, Juan, Pineda, Juan A, Fernandez-Fuertes, Marta, Wang, Xiaomin, Karadeniz, Zehra, Saccomanno, Jacopo, Doehn, Jan-Moritz, Hübner, Ralf-Harto, Hinzmann, Bernd, Salvo, Mauricio, Blueher, Anja, Siemann, Sandra, Jurisic, Stjepan, Beer, Juerg H., Rutishauser, Jonas, Wiggli, Benedikt, Schmid, Hansruedi, Danninger, Kathrin, Binder, Ronald, Corman, Victor M, Mühlemann, Barbara, Arjun Arkal, Rao, Fragiadakis, Gabriela K., Mick, Eran, COMET, Consortium, Calfee, Carolyn S., Erle, David J., Hendrickson, Carolyn M., Kangelaris, Kirsten N., Krummel, Matthew F., Woodruff, Prescott G., Langelier, Charles R., Venkataramani, Urmila, García, Federico, Zyla, Joanna, Drosten, Christian, Alice, Braun, Jones, Terry C, Suttorp, Norbert, Witzenrath, Martin, Hippenstiel, Stefan, Zemojtel, Tomasz, Skurk, Carsten, Poller, Wolfgang, Borodina, Tatiana, Pa-COVID, Study Group, Ripke, Stephan, Sander, Leif E, Beule, Dieter, Landmesser, Ulf, Guettouche, Toumy, Kurth, Florian, and Heidecker, Bettina
- Published
- 2021
- Full Text
- View/download PDF
13. Lifelong dietary omega-3 fatty acid suppresses thrombotic potential through gut microbiota alteration in aged mice
- Author
-
Saeedi Saravi, Seyed Soheil, Bonetti, Nicole R., Pugin, Benoit, Constancias, Florentin, Pasterk, Lisa, Gobbato, Sara, Akhmedov, Alexander, Liberale, Luca, Lüscher, Thomas F., Camici, Giovanni G., and Beer, Jürg H.
- Published
- 2021
- Full Text
- View/download PDF
14. Long-term dietary supplementation with plant-derived omega-3 fatty acid improves outcome in experimental ischemic stroke
- Author
-
Bonetti, Nicole R., Liberale, Luca, Akhmedov, Alexander, Pasterk, Lisa, Gobbato, Sara, Puspitasari, Yustina M., Vukolic, Ana, Saeedi Saravi, Seyed Soheil, Coester, Bernd, Horvath, Carla, Osto, Elena, Montecucco, Fabrizio, Lüscher, Thomas F., Beer, Jürg H., and Camici, Giovanni G.
- Published
- 2021
- Full Text
- View/download PDF
15. Reduced adrenal stress response in patients on PCSK9 inhibitor therapy
- Author
-
Meier, Simon, Frick, Marcel, Liu, Michael, Saeedi Saravi, Seyed Soheil, Montrasio, Giulia, Preiss, Helga, Pasterk, Lisa, Bonetti, Nicole, Egloff, Michael, Schmid, Hans-Rudolf, Sudano, Isabella, Camici, Giovanni G., Mach, François, Luescher, Thomas F., Ehret, Georg, and Beer, Jürg H.
- Published
- 2021
- Full Text
- View/download PDF
16. Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation
- Author
-
Aeschbacher, Stefanie, Auberson, Chloé, Blum, Steffen, Bonati, Leo, Ceylan, Selinda, Conen, David, Doerpfeld, Simone, Eken, Ceylan, Girod, Marc, Hämmerle, Peter, Krisai, Philipp, Kühne, Michael, Meyer-Zürn, Christine, Meyre, Pascal, Monsch, Andreas U., Müller, Christian, Osswald, Stefan, Springer, Anne, Sticherling, Christian, Szucs, Thomas, Voellmin, Gian, Zwimpfer, Leon, Aujesky, Drahomir, Fischer, Urs, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Loewe, Axel, Moutzouri, Elisavet, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Rodondi, Nicolas, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Müller, Andreas, Fontana, Simone, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Beer, Jürg-Hans, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Caputo, Maria Luce, Regoli, Francois, Moccetti, Tiziano, Brenner, Roman, Altmann, David, Gemperle, Michaela, Ammann, Peter, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Hayoz, Daniel, Berte, Benjamin, Justi, Virgina, Kellner-Weldon, Frauke, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Zbinden, Melanie, Kobza, Richard, Frangi-Kultalahti, Jane, Pin, Anica, Vicari, Luisa, Moschovitis, Giorgio, Ehret, Georg, Gallet, Hervé, Guillermet, Elise, Lazeyras, Francois, Lovblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres, Cheryl, Shah, Dipen, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Schläpfer, Jürg, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Stephan, Frank-Peter, Gallino, Augusto, Di Valentino, Marcello, Witassek, Fabienne, Schwenkglenks, Matthias, Würfel, Jens, Altermatt, Anna, Amann, Michael, Huber, Petra, Ruberte, Esther, Sinnecker, Tim, Zuber, Vanessa, Coslovsky, Michael, Benkert, Pascal, Dutilh, Gilles, Markovic, Milica, Simon, Patrick, Schmid, Ramun, Beer, Jürg H., Bonati, Leo H., Blum, Manuel R., Kastner, Peter, and Baguley, Fiona
- Published
- 2021
- Full Text
- View/download PDF
17. Abstract 11851: Acetate Rescues the Gut Microbial Metabolites PAA/PAG-induced Vascular Senescence by Epigenetic and SASP Regulation
- Author
-
Saeedi, Soheil, Thomas, Aurélien, LeGludic, Sylvain, Gergely, Karsai, Lettlova, Sandra, Osto, Elena, Allemann, Meret, Lee, Pratintip, and Beer, Juerg H
- Published
- 2022
- Full Text
- View/download PDF
18. Patients on vitamin K treatment: is switching to direct-acting oral anticoagulation cost-effective? A target trial on a prospective cohort.
- Author
-
Aebersold, Helena, Foster-Witassek, Fabienne, Aeschbacher, Stefanie, Beer, Juerg H., Blozik, Eva, Blum, Manuel, Bonati, Leo, Conte, Giulio, Coslovsky, Michael, De Perna, Maria Luisa, Di Valentino, Marcello, Felder, Stefan, Huber, Carola A., Moschovitis, Giorgio, Mueller, Andreas, Paladini, Rebecca E., Reichlin, Tobias, Rodondi, Nicolas, Stauber, Annina, and Sticherling, Christian
- Published
- 2024
- Full Text
- View/download PDF
19. Symptoms and quality of life in patients with coexistent atrial fibrillation and atrial flutter
- Author
-
Stempfel, Samuel, Aeschbacher, Stefanie, Blum, Steffen, Meyre, Pascal, Gugganig, Rebecca, Beer, Jürg H., Kobza, Richard, Kühne, Michael, Moschovitis, Giorgio, Menghini, Gianluca, Novak, Jan, Osswald, Stefan, Rodondi, Nicolas, Moutzouri, Elisavet, Schwenkglenks, Matthias, Witassek, Fabienne, Conen, David, and Sticherling, Christian
- Published
- 2020
- Full Text
- View/download PDF
20. Sirt6 deletion in bone marrow-derived cells increases atherosclerosis – Central role of macrophage scavenger receptor 1
- Author
-
Arsiwala, Tasneem, Pahla, Jürgen, van Tits, Lambertus J., Bisceglie, Lavinia, Gaul, Daniel S., Costantino, Sarah, Miranda, Melroy X., Nussbaum, Kathrin, Stivala, Simona, Blyszczuk, Przemyslaw, Weber, Julien, Tailleux, Anne, Stein, Sokrates, Paneni, Francesco, Beer, Jürg H., Greter, Melanie, Becher, Burkhard, Mostoslavsky, Raul, Eriksson, Urs, Staels, Bart, Auwerx, Johan, Hottiger, Michael O., Lüscher, Thomas F., and Matter, Christian M.
- Published
- 2020
- Full Text
- View/download PDF
21. Relationships of Overt and Silent Brain Lesions With Cognitive Function in Patients With Atrial Fibrillation
- Author
-
Berger, Sebastian, Bernasconi, Raffaele, Fröhlich, Lorin, Göldi, Tobias, Gugganig, Rebecca, Kofler, Thomas, Krisai, Philipp, Mongiat, Michel, Pudenz, Christiane, Repilado, Javier Ruperti, Schweizer, Aleksandra, Springer, Anne, Stempfel, Samuel, Szucs, Thomas, van der Stouwe, Jan, Voellmin, Gian, Zwimpfer, Leon, Aujesky, Drahomir, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Schneider, Claudio, Loewe, Axel, Flückiger, Tanja, Groen, Cindy, Schwab, Nathalie, Beynon, Christopher, Dillier, Roger, Eberli, Franz, Fontana, Simone, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Schneider, Xiaoye, Studerus, Katrin, Weishaupt, Dominik, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Bello, Corina, Isberg, Henriette, Grau, Alexandra, Villinger, Jonas, Papaux, Mary-Monica, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Caputo, Maria Luce, Regoli, Francois, Moccetti, Tiziano, Brenner, Roman, Altmann, David, Forrer, Manuela, Gemperle, Michaela, Firmann, Mathieu, Foucras, Sandrine, Berte, Benjamin, Kaeppeli, Andrea, Mehmann, Brigitta, Pfeiffer, Markus, Russi, Ian, Schmidt, Kai, Weberndoerfer, Vanessa, Young, Mabelle, Zbinden, Melanie, Vicari, Luisa, Frangi, Jane, Terrot, Tatiana, Gallet, Hervé, Guillermet, Elise, Lazeyras, Francois, Lovblad, Karl-Olof, Perret, Patrick, Teres, Cheryl, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Arenja, Nisha, Grêt, Andrea, Vitelli, Sandra, Gallino, Augusto, Schoenenberger-Berzins, Renate, Witassek, Fabienne, Radue, Ernst-Wilhelm, Benkert, Pascal, Fabbro, Thomas, Simon, Patrick, Schmid, Ramun, Conen, David, Rodondi, Nicolas, Müller, Andreas, Beer, Juerg H., Ammann, Peter, Moschovitis, Giorgio, Auricchio, Angelo, Hayoz, Daniel, Kobza, Richard, Shah, Dipen, Novak, Jan, Schläpfer, Jürg, Di Valentino, Marcello, Aeschbacher, Stefanie, Blum, Steffen, Meyre, Pascal, Sticherling, Christian, Bonati, Leo H., Ehret, Georg, Moutzouri, Elisavet, Fischer, Urs, Monsch, Andreas U., Stippich, Christoph, Wuerfel, Jens, Sinnecker, Tim, Coslovsky, Michael, Schwenkglenks, Matthias, Kühne, Michael, and Osswald, Stefan
- Published
- 2019
- Full Text
- View/download PDF
22. Thrombin Generation Is Associated with Venous Thromboembolism Recurrence, but Not with Major Bleeding and Death in the Elderly: A Prospective Multicenter Cohort Study
- Author
-
Vrotniakaite-Bajerciene, Kristina, primary, Rütsche, Sereina, additional, Calzavarini, Sara, additional, Quarroz, Claudia, additional, Stalder, Odile, additional, Mean, Marie, additional, Righini, Marc, additional, Staub, Daniel, additional, Beer, Juerg H., additional, Frauchiger, Beat, additional, Osterwalder, Joseph, additional, Kucher, Nils, additional, Matter, Christian M., additional, Husmann, Marc, additional, Banyai, Martin, additional, Aschwanden, Markus, additional, Mazzolai, Lucia, additional, Hugli, Olivier, additional, Rodondi, Nicolas, additional, Aujesky, Drahomir, additional, and Angelillo-Scherrer, Anne, additional
- Published
- 2023
- Full Text
- View/download PDF
23. δppfor, Clostridium_ASF356 mutants prevent perivascular adipose tissue and endothelial senescence
- Author
-
Pugin, Benoit, Constancias, Florentin, Thomas, Aurélien, Le Gludic, Sylvain, Menni, Cristina, Beer, Jürg H., Paneni, Francesco, Ruschitzka, Frank, and Saeedi Saravi, Seyed Soheil
- Published
- 2024
- Full Text
- View/download PDF
24. Circulating large extracellular vesicles from STEMI patients contribute to cardiovascular damage
- Author
-
Balbi, Carolina, Senesi, Giorgia, Ministrini, Stefano, Brucale, Marco, Valle, Francesco, Frigerio, Roberto, Bergese, Paolo, Akhmedov, Alexander, Beer, Jürg H., Camici, Giovanni, and Vassalli, Giuseppe
- Published
- 2024
- Full Text
- View/download PDF
25. Sirtuin 5 as a novel target to blunt blood–brain barrier damage induced by cerebral ischemia/reperfusion injury
- Author
-
Diaz-Cañestro, Candela, Merlini, Mario, Bonetti, Nicole R., Liberale, Luca, Wüst, Patricia, Briand-Schumacher, Sylvie, Klohs, Jan, Costantino, Sara, Miranda, Melroy, Schoedon-Geiser, Gabriele, Kullak-Ublick, Gerd A., Akhmedov, Alexander, Paneni, Francesco, Beer, Jürg H., Lüscher, Thomas F., and Camici, Giovanni G.
- Published
- 2018
- Full Text
- View/download PDF
26. Physical activity and brain health in patients with atrial fibrillation
- Author
-
SWISS-AF Investigators, Herber, Elena, Aeschbacher, Stefanie, Coslovsky, Michael, Schwendinger, Fabian, Hennings, Elisa, Gasser, Andreas, Di Valentino, Marcello, Rigamonti, Elia, Reichlin, Tobias, Rodondi, Nicolas, Netzer, Seraina, Beer, Juerg H, Stauber, Annina, Mueller, Andreas, Ammann, Peter, Sinnecker, Tim, Düring, Marco, Wuerfel, Jens, Conen, David, Kühne, Michael, Osswald, Stefan, Bonati, Leo H, and Clinical sciences
- Subjects
neurocognitive function ,Neurology ,cerebral microbleeds ,total brain volume ,White matter disease ,Neuroscience(all) ,Atrial Fibrillation ,Physical Activity ,Neurology (clinical) ,cerebral infarction ,Cardiology and Cardiovascular Medicine ,cognitive disorders and dementia - Abstract
Background and purpose: Vascular brain lesions, such as ischemic infarcts, are common among patients with atrial fibrillation (AF) and are associated with impaired cognitive function. The role of physical activity (PA) in the prevalence of brain lesions and cognition in AF has not been investigated. Methods: Patients from the multicenter Swiss-AF cohort study were included in this cross-sectional analysis. We assessed regular exercise (RE; at least once weekly) and minutes of weekly PA using a validated questionnaire. We studied associations with ischemic infarcts, white matter hyperintensities, cerebral microbleeds, and brain volume on brain magnetic resonance imaging and with global cognition measured with a cognitive construct (CoCo) score. Results: Among 1490 participants (mean age = 72 ± 9 years), 730 (49%) engaged in RE. In adjusted regression analyses, RE was associated with a lower prevalence of ischemic infarcts (odds ratio [OR] = 0.78, 95% confidence interval [CI] = 0.63–0.98, p = 0.03) and of moderate to severe white matter hyperintensities (OR = 0.78, 95% CI = 0.62–0.99, p = 0.04), higher brain volume (β-coefficient = 10.73, 95% CI = 2.37–19.09, p = 0.01), and higher CoCo score (β-coefficient = 0.08, 95% CI = 0.03–0.12, p < 0.001). Increasing weekly PA was associated with higher brain volume (β-coefficient = 1.40, 95% CI = 0.65–2.15, p < 0.001). Conclusions: In AF patients, RE was associated with a lower prevalence of ischemic infarcts and of moderate to severe white matter disease, with larger brain volume, and with better cognitive performance. Prospective studies are needed to investigate whether these associations are causal. Until then, our findings suggest that patients with AF should be encouraged to remain physically active.
- Published
- 2022
27. Association of chocolate consumption with neurological and cardiovascular outcomes in atrial fibrillation: data from two Swiss atrial fibrillation cohort studies (Swiss-AF and BEAT-AF)
- Author
-
Stauber, Annina, primary, Müller, Andreas, additional, Rommers, Nikki, additional, Aeschbacher, Stefanie, additional, Rodondi, Nicolas, additional, Bonati, Leo H., additional, Beer, Juerg H., additional, Jeger, Raban V., additional, Kurz, David J., additional, Liedtke, Claudia, additional, Ammann, Peter, additional, Di Valentino, Marcello, additional, Chocano, Patricia, additional, Kobza, Richard, additional, Kühne, Michael, additional, Conen, David, additional, Osswald, Stefan, additional, and Bernheim, Alain M., additional
- Published
- 2023
- Full Text
- View/download PDF
28. Mid-term changes in cognitive functions in patients with atrial fibrillation: a longitudinal analysis of the Swiss-AF cohort
- Author
-
Wueest, Alexandra S., primary, Zuber, Priska, additional, Coslovsky, Michael, additional, Rommers, Nikki, additional, Rodondi, Nicolas, additional, Gencer, Baris, additional, Moschovitis, Giorgio, additional, De Perna, Maria Luisa, additional, Beer, Juerg H., additional, Reichlin, Tobias, additional, Krisai, Philipp, additional, Springer, Anne, additional, Conen, David, additional, Stauber, Annina, additional, Mueller, Andreas S., additional, Paladini, Rebecca E., additional, Kuhne, Michael, additional, Osswald, Stefan, additional, Monsch, Andreas U., additional, and Bonati, Leo H., additional
- Published
- 2023
- Full Text
- View/download PDF
29. Thrombin Generation is Associated with Venous Thrombo-embolism Recurrence, but not with Major Bleeding and Death in the Elderly: A Prospective Multicenter Cohort Study
- Author
-
Vrotniakaite-Bajerciene, Kristina, primary, Rütsche, Sereina, additional, Calzavarini, Sara, additional, Quarroz, Claudia, additional, Stalder, Odile, additional, Méan, Marie, additional, Righini, Marc, additional, Staub, Daniel, additional, Beer, Juerg H., additional, Frauchiger, Beat, additional, Österwalder, Joseph, additional, Kucher, Nils, additional, Matter, Christian M., additional, Husmann, Marc, additional, Banyai, Martin, additional, Aschwanden, Markus, additional, Mazzolai, Lucia, additional, Hugli, Olivier, additional, Rodondi, Nicolas, additional, Aujesky, Drahomir, additional, and Angelillo-Scherrer, Anne, additional
- Published
- 2023
- Full Text
- View/download PDF
30. Mid-term changes in cognitive functions in patients with atrial fibrillation: a longitudinal analysis of the Swiss-AF cohort
- Author
-
Wueest, Alexandra S, Zuber, Priska, Coslovsky, Michael; https://orcid.org/0000-0001-7678-7354, Rommers, Nikki; https://orcid.org/0000-0003-0311-5009, Rodondi, Nicolas; https://orcid.org/0000-0001-9083-6896, Gencer, Baris; https://orcid.org/0000-0002-8954-9694, Moschovitis, Giorgio; https://orcid.org/0000-0002-4043-8061, De Perna, Maria Luisa; https://orcid.org/0000-0003-1171-7640, Beer, Juerg H, Reichlin, Tobias; https://orcid.org/0000-0002-7197-8415, Krisai, Philipp; https://orcid.org/0000-0002-4367-2363, Springer, Anne; https://orcid.org/0000-0002-4829-1041, Conen, David; https://orcid.org/0000-0002-2459-5251, Stauber, Annina; https://orcid.org/0009-0008-6006-8177, Mueller, Andreas S, Paladini, Rebecca E; https://orcid.org/0000-0002-4502-1978, Kuhne, Michael, Osswald, Stefan; https://orcid.org/0000-0002-9240-6731, Monsch, Andreas U, Bonati, Leo H; https://orcid.org/0000-0003-1163-8133, Wueest, Alexandra S, Zuber, Priska, Coslovsky, Michael; https://orcid.org/0000-0001-7678-7354, Rommers, Nikki; https://orcid.org/0000-0003-0311-5009, Rodondi, Nicolas; https://orcid.org/0000-0001-9083-6896, Gencer, Baris; https://orcid.org/0000-0002-8954-9694, Moschovitis, Giorgio; https://orcid.org/0000-0002-4043-8061, De Perna, Maria Luisa; https://orcid.org/0000-0003-1171-7640, Beer, Juerg H, Reichlin, Tobias; https://orcid.org/0000-0002-7197-8415, Krisai, Philipp; https://orcid.org/0000-0002-4367-2363, Springer, Anne; https://orcid.org/0000-0002-4829-1041, Conen, David; https://orcid.org/0000-0002-2459-5251, Stauber, Annina; https://orcid.org/0009-0008-6006-8177, Mueller, Andreas S, Paladini, Rebecca E; https://orcid.org/0000-0002-4502-1978, Kuhne, Michael, Osswald, Stefan; https://orcid.org/0000-0002-9240-6731, Monsch, Andreas U, and Bonati, Leo H; https://orcid.org/0000-0003-1163-8133
- Abstract
Background: Longitudinal association studies of atrial fibrillation (AF) and cognitive functions have shown an unclear role of AF-type and often differ in methodological aspects. We therefore aim to investigate longitudinal changes in cognitive functions in association with AF-type (non-paroxysmal vs. paroxysmal) and comorbidities in the Swiss-AF cohort. Methods: Seven cognitive measures were administered up to five times between 2014 and 2022. Age-education standardized scores were calculated and association between longitudinal change in scores and baseline AF-type investigated using linear mixed-effects models. Associations between AF-type and time to cognitive drop, an observed score of at least one standard deviation below individual's age-education standardized cognitive scores at baseline, were studied using Cox proportional hazard models of each cognitive test, censoring patients at their last measurement. Models were adjusted for baseline covariates.Results2,415 AF patients (mean age 73.2 years; 1,080 paroxysmal, 1,335 non-paroxysmal AF) participated in this Swiss multicenter prospective cohort study. Mean cognitive scores increased longitudinally (median follow-up 3.97 years). Non-paroxysmal AF patients showed smaller longitudinal increases in Digit Symbol Substitution Test (DSST), Cognitive Construct Score (CoCo)and Trail Making Test part B (TMT-B) scores vs. paroxysmal AF patients. Diabetes, history of stroke/TIA and depression were associated with worse performance on all cognitive tests. No differences in time to cognitive drop were observed between AF-types in any cognitive test. Conclusion: This study indicated preserved cognitive functioning in AF patients, best explained by practice effects. Smaller practice effects were found in non-paroxysmal AF patients in the DSST, TMT-B and the CoCo and could indicate a marker of subtle cognitive decline. As diabetes, history of stroke/TIA and depression—but not AF-type—were associated with cognitive drop, mor
- Published
- 2023
31. Association of chocolate consumption with neurological and cardiovascular outcomes in atrial fibrillation: data from two Swiss atrial fibrillation cohort studies (Swiss-AF and BEAT-AF)
- Author
-
Stauber, Annina; https://orcid.org/0009-0008-6006-8177, Müller, Andreas, Rommers, Nikki; https://orcid.org/0000-0003-0311-5009, Aeschbacher, Stefanie; https://orcid.org/0000-0001-8134-2421, Rodondi, Nicolas; https://orcid.org/0000-0001-9083-6896, Bonati, Leo H; https://orcid.org/0000-0003-1163-8133, Beer, Juerg H, Jeger, Raban V; https://orcid.org/0000-0003-1290-5491, Kurz, David J; https://orcid.org/0000-0002-3921-6939, Liedtke, Claudia, Ammann, Peter, Di Valentino, Marcello; https://orcid.org/0000-0001-9088-6973, Chocano, Patricia, Kobza, Richard; https://orcid.org/0000-0003-3988-7262, Kühne, Michael; https://orcid.org/0000-0002-2937-3711, Conen, David; https://orcid.org/0000-0002-2459-5251, Osswald, Stefan; https://orcid.org/0000-0002-9240-6731, Bernheim, Alain M, Stauber, Annina; https://orcid.org/0009-0008-6006-8177, Müller, Andreas, Rommers, Nikki; https://orcid.org/0000-0003-0311-5009, Aeschbacher, Stefanie; https://orcid.org/0000-0001-8134-2421, Rodondi, Nicolas; https://orcid.org/0000-0001-9083-6896, Bonati, Leo H; https://orcid.org/0000-0003-1163-8133, Beer, Juerg H, Jeger, Raban V; https://orcid.org/0000-0003-1290-5491, Kurz, David J; https://orcid.org/0000-0002-3921-6939, Liedtke, Claudia, Ammann, Peter, Di Valentino, Marcello; https://orcid.org/0000-0001-9088-6973, Chocano, Patricia, Kobza, Richard; https://orcid.org/0000-0003-3988-7262, Kühne, Michael; https://orcid.org/0000-0002-2937-3711, Conen, David; https://orcid.org/0000-0002-2459-5251, Osswald, Stefan; https://orcid.org/0000-0002-9240-6731, and Bernheim, Alain M
- Abstract
AIM: To assess the associations of chocolate consumption with neurocognitive function, brain lesions on magnetic resonance imaging (MRI), and cardiovascular outcome in patients with atrial fibrillation (AF). METHODS: We analysed data from patients of two prospective multicentre Swiss atrial fibrillation cohort studies (Swiss-AF) and (BEAT-AF). Assessments of MRI findings and neurocognitive function were performed only in the Swiss-AF population (in 1727 of 2415 patients [71.5%] with a complete data set), as patients enrolled in BEAT-AF were not systematically evaluated for these outcomes. Otherwise, the two cohorts had an equivalent set of clinical assessments. Clinical outcome analysis was performed in 3931 patients of both cohorts. Chocolate consumption was assessed by questionnaire. Patients were categorised as no/low chocolate consumption (No/Low-Ch) ≤1 servings/week, moderate chocolate consumption (Mod-Ch) >1–6 servings/week, and high chocolate consumption (High-Ch) >6 servings/week, respectively. Brain lesions were evaluated by MRI. Assessment of cognitive function was performed by neurocognitive functional testing and included global cognition measurement with a cognitive construct score. Cerebral MRI and cognition were evaluated at baseline. Cross-sectional associations between chocolate consumption and MRI findings were analysed by multivariate logistic regression models and associations with neurocognitive function by multivariate linear regression models. Clinical outcome events during follow-up were recorded and assessed by a clinical event committee. The associations between chocolate consumption and clinical outcomes were evaluated by Cox regression models. The median follow-up time was 6 years. RESULTS: Chocolate consumption was not associated with prevalence or volume of vascular brain lesions on MRI, nor major adverse cardiac events (ischaemic stroke, myocardial infarction, cardiovascular death). However, No/Low-Ch was independently associated with
- Published
- 2023
32. Thrombin Generation Is Associated with Venous Thromboembolism Recurrence, but Not with Major Bleeding and Death in the Elderly: A Prospective Multicenter Cohort Study
- Author
-
Vrotniakaite-Bajerciene, Kristina; https://orcid.org/0000-0003-1381-4858, Rütsche, Sereina, Calzavarini, Sara, Quarroz, Claudia, Stalder, Odile, Mean, Marie, Righini, Marc; https://orcid.org/0000-0003-1211-2969, Staub, Daniel; https://orcid.org/0000-0001-5956-2698, Beer, Juerg H, Frauchiger, Beat, Osterwalder, Joseph, Kucher, Nils, Matter, Christian M; https://orcid.org/0000-0002-8124-1767, Husmann, Marc, Banyai, Martin, Aschwanden, Markus, Mazzolai, Lucia, Hugli, Olivier; https://orcid.org/0000-0003-2312-1625, Rodondi, Nicolas, Aujesky, Drahomir, Angelillo-Scherrer, Anne, Vrotniakaite-Bajerciene, Kristina; https://orcid.org/0000-0003-1381-4858, Rütsche, Sereina, Calzavarini, Sara, Quarroz, Claudia, Stalder, Odile, Mean, Marie, Righini, Marc; https://orcid.org/0000-0003-1211-2969, Staub, Daniel; https://orcid.org/0000-0001-5956-2698, Beer, Juerg H, Frauchiger, Beat, Osterwalder, Joseph, Kucher, Nils, Matter, Christian M; https://orcid.org/0000-0002-8124-1767, Husmann, Marc, Banyai, Martin, Aschwanden, Markus, Mazzolai, Lucia, Hugli, Olivier; https://orcid.org/0000-0003-2312-1625, Rodondi, Nicolas, Aujesky, Drahomir, and Angelillo-Scherrer, Anne
- Abstract
It is currently unknown whether thrombin generation is associated with venous thromboembolism (VTE) recurrence, major bleeding, or mortality in the elderly. Therefore, our aim was to prospectively study the association between thrombin generation and VTE recurrence, major bleeding, and mortality in elderly patients with acute VTE. Consecutive patients aged ≥65 years with acute VTE were followed for 2 years, starting from 1 year after the index VTE. Primary outcomes were VTE recurrence, major bleeding, and mortality. Thrombin generation was assessed in 551 patients 1 year after the index VTE. At this time, 59% of the patients were still anticoagulated. Thrombin generation was discriminatory for VTE recurrence, but not for major bleeding and mortality in non-anticoagulated patients. Moreover, peak ratio (adjusted subhazard ratio 4.09, 95% CI, 1.12-14.92) and normalized peak ratio (adjusted subhazard ratio 2.18, 95% CI, 1.28-3.73) in the presence/absence of thrombomodulin were associated with VTE recurrence, but not with major bleeding and mortality after adjustment for potential confounding factors. In elderly patients, thrombin generation was associated with VTE recurrence, but not with major bleeding and/or mortality. Therefore, our study suggests the potential usefulness of thrombin generation measurement after anticoagulation completion for VTE to help identify among elderly patients those at higher risk of VTE recurrence.
- Published
- 2023
33. Abstract 20271: Assisted Reproductive Technologies Increase the Functional and Morphological Severity of Stroke in Mice
- Author
-
Bonetti, Nicole R, Meister, Théo A, Soria, Rodrigo, Rexhaj, Emrush, Beer, Juerg H, Camici, Giovanni G, and Scherrer, Urs
- Published
- 2017
34. Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression
- Author
-
Reiner, Martin F., Akhmedov, Alexander, Stivala, Simona, Keller, Stephan, Gaul, Daniel S., Bonetti, Nicole R., Savarese, Gianluigi, Glanzmann, Martina, Zhu, Cuicui, Ruf, Wolfram, Yang, Zhihong, Matter, Christian M., Lüscher, Thomas F., Camici, Giovanni G., and Beer, Juerg H.
- Published
- 2017
- Full Text
- View/download PDF
35. Physical activity and brain health in patients with atrial fibrillation.
- Author
-
Herber, Elena, Aeschbacher, Stefanie, Coslovsky, Michael, Schwendinger, Fabian, Hennings, Elisa, Gasser, Andreas, Di Valentino, Marcello, Rigamonti, Elia, Reichlin, Tobias, Rodondi, Nicolas, Netzer, Seraina, Beer, Juerg H., Stauber, Annina, Müller, Andreas, Ammann, Peter, Sinnecker, Tim, Duering, Marco, Wuerfel, Jens, Conen, David, and Kühne, Michael
- Subjects
ATRIAL fibrillation ,PHYSICAL activity ,LEUKOENCEPHALOPATHIES ,LACUNAR stroke ,MAGNETIC resonance imaging ,BRAIN damage ,CEREBRAL infarction - Abstract
Background and purpose: Vascular brain lesions, such as ischemic infarcts, are common among patients with atrial fibrillation (AF) and are associated with impaired cognitive function. The role of physical activity (PA) in the prevalence of brain lesions and cognition in AF has not been investigated. Methods: Patients from the multicenter Swiss‐AF cohort study were included in this cross‐sectional analysis. We assessed regular exercise (RE; at least once weekly) and minutes of weekly PA using a validated questionnaire. We studied associations with ischemic infarcts, white matter hyperintensities, cerebral microbleeds, and brain volume on brain magnetic resonance imaging and with global cognition measured with a cognitive construct (CoCo) score. Results: Among 1490 participants (mean age = 72 ± 9 years), 730 (49%) engaged in RE. In adjusted regression analyses, RE was associated with a lower prevalence of ischemic infarcts (odds ratio [OR] = 0.78, 95% confidence interval [CI] = 0.63–0.98, p = 0.03) and of moderate to severe white matter hyperintensities (OR = 0.78, 95% CI = 0.62–0.99, p = 0.04), higher brain volume (β‐coefficient = 10.73, 95% CI = 2.37–19.09, p = 0.01), and higher CoCo score (β‐coefficient = 0.08, 95% CI = 0.03–0.12, p < 0.001). Increasing weekly PA was associated with higher brain volume (β‐coefficient = 1.40, 95% CI = 0.65–2.15, p < 0.001). Conclusions: In AF patients, RE was associated with a lower prevalence of ischemic infarcts and of moderate to severe white matter disease, with larger brain volume, and with better cognitive performance. Prospective studies are needed to investigate whether these associations are causal. Until then, our findings suggest that patients with AF should be encouraged to remain physically active. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
36. MALE SEX, HLA-C*04:01 AND COVID-19: A RISKY CONSTELLATION
- Author
-
Suwalski, Phillip, primary, Patriki, Dimitri, additional, Quedenau, Claudia, additional, Borodina, Tatiana, additional, Beer, Juerg H., additional, Wiggli, Benedikt, additional, Guettouche, Toumy, additional, Landmesser, Ulf, additional, and Heidecker, Bettina, additional
- Published
- 2022
- Full Text
- View/download PDF
37. Physical Activity and Brain Health in Patients with Atrial Fibrillation
- Author
-
Herber, Elena, Aeschbacher, Stefanie, Coslovsky, Michael, Schwendinger, Fabian, Hennings, Elisa, Gasser, Andreas, Di Valentino, Marcello, Rigamonti, Elia, Reichlin, Tobias, Rodondi, Nicolas, Netzer, Seraina, Beer, Juerg H, Stauber, Annina, Müller, Andreas, Ammann, Peter, Sinnecker, Tim, Duering, Marco, Wuerfel, Jens, Conen, David, Kühne, Michael, Osswald, Stefan, and Bonati, Leo H
- Subjects
360 Soziale Probleme, Sozialdienste ,610 Medizin und Gesundheit - Abstract
BACKGROUND Vascular brain lesions, such as ischemic infarcts, are common among patients with atrial fibrillation (AF) and are associated with impaired cognitive function. The role of physical activity in the prevalence of brain lesions and cognition in AF has not been investigated. METHODS Patients from the multicenter Swiss-AF cohort study were included in this cross-sectional analysis. We assessed regular exercise (at least once weekly) and minutes of weekly physical activity using a validated questionnaire. We studied associations with ischemic infarcts, white matter hyperintensities, cerebral microbleeds, and brain volume on brain MRI and with global cognition measured with a cognitive construct score (CoCo). RESULTS Among 1490 participants (mean age 72 ±9 years), 730 (49%) engaged in regular exercise. In adjusted regression analyses, regular exercise was associated with a lower prevalence of ischemic infarcts (odds ratio [OR]) 0.78, 95% CI 0.63-0.98, p=0.03) and of moderate to severe white matter hyperintensities (OR 0.78, 95% CI 0.62-0.99, p=0.04), higher brain volume (β-coefficient 10.73, 95% CI 2.37-19.09, p=0.01), and higher CoCo score (β-coefficient 0.08, 95% CI 0.03-0.12, p
- Published
- 2022
- Full Text
- View/download PDF
38. Towards personalized antithrombotic management with drugs and devices across the cardiovascular spectrum
- Author
-
Lüscher, Thomas F, primary, Davies, Allan, additional, Beer, Juerg H, additional, Valgimigli, Marco, additional, Nienaber, Christoph A, additional, Camm, John A, additional, Baumgartner, Iris, additional, Diener, Hans-Christoph, additional, and Konstantinides, Stavros V, additional
- Published
- 2021
- Full Text
- View/download PDF
39. Heart rate and adverse outcomes in patients with prevalent atrial fibrillation
- Author
-
Moschovitis, Giorgio, Johnson, Linda S B, Blum, Steffen, Aeschbacher, Stefanie, De Perna, Maria Luisa, Pagnamenta, Alberto, Mayer Melchiorre, Patrizia Assunta, Benz, Alexander P, Kobza, Richard, Di Valentino, Marcello, Zuern, Christine S, Auricchio, Angelo, Conte, Giulio, Rodondi, Nicolas, Blum, Manuel R, Beer, Juerg H, Kühne, Michael, Osswald, Stefan, and Conen, David
- Subjects
360 Social problems & social services ,610 Medicine & health - Abstract
OBJECTIVE The optimal target heart rate in patients with prevalent atrial fibrillation (AF) is not well defined. The aim of this study was to analyse the associations between heart rate and adverse outcomes in a large contemporary cohort of patients with prevalent AF. METHODS From two prospective cohort studies, we included stable AF outpatients who were in AF on the baseline ECG. The main outcome events assessed during prospective follow-up were heart failure hospitalisation, stroke or systemic embolism and death. The associations between heart rate and adverse outcomes were evaluated using multivariable Cox regression models. RESULTS The study population consisted of 1679 patients who had prevalent AF at baseline. Mean age was 74 years, and 24.6% were women. The mean heart rate on the baseline ECG was 78 (±19) beats per minute (bpm). The median follow-up was 3.9 years (IQR 2.2-5.0). Heart rate was not significantly associated with heart failure hospitalisation (adjusted HR (aHR) per 10 bpm increase, 1.00, 95% CI 0.94 to 1.07, p=0.95), stroke or systemic embolism (aHR 0.95, 95% CI 0.84 to 1.07, p=0.38) or death (aHR 1.02, 95% CI 0.95 to 1.09, p=0.66). There was no evidence of a threshold effect for heart rates 100 bpm. CONCLUSIONS In this large contemporary cohort of outpatients with prevalent AF, we found no association between heart rate and adverse outcome events. These data are in line with recommendations that strict heart rate control is not needed in otherwise stable outpatients with AF.
- Published
- 2021
40. Cardioversion in patients with newly diagnosed non-valvular atrial fibrillation: Observational study using prospectively collected registry data
- Author
-
Pope, Marita Knudsen, Hall, Trygve S, Schirripa, Valentina, Radic, Petra, Virdone, Saverio, Pieper, Karen S, Le Heuzey, Jean-Yves, Jansky, Petr, Fitzmaurice, David A, Cappato, Riccardo, Atar, Dan, Camm, A John, Kakkar, Ajay K, Bassand, Jean-Pierre, Fox, Keith A A, Gersh, Bernard J, Goldhaber, Samuel Z, Goto, Shinya, Haas, Sylvia, Hacke, Werner, Mantovani, Lorenzo G, Misselwitz, Frank, Turpie, Alexander G G, van Eickels, Martin, Verheugt, Freek W A, Luciardi, Hector Lucas, Gibbs, Harry, Brodmann, Marianne, Cools, Frank, Barretto, Antonio Carlos Pereira, Connolly, Stuart J, Eikelboom, John, Corbalan, Ramon, Jing, Zhi-Cheng, Nielsen, Jørn Dalsgaard, Ragy, Hany, Raatikainen, Pekka, Darius, Harald, Keltai, Matyas, Sawhney, Jitendra Pal Singh, Agnelli, Giancarlo, Ambrosio, Giuseppe, Koretsune, Yukihiro, Sánchez Díaz, Carlos Jerjes, Ten Cate, Hugo, Stepinska, Janina, Panchenko, Elizaveta, Lim, Toon Wei, Jacobson, Barry, Oh, Seil, Viñolas, Xavier, Rosenqvist, Marten, Steffel, Jan, Angchaisuksiri, Pantep, Oto, Ali, Parkhomenko, Alex, Al Mahmeed, Wael, Hu, Dayi, Chen, Kangning, Zhao, Yusheng, Zhang, Huaiqin, Chen, Jiyan, Cao, Shiping, Wang, Daowen, Yang, Yuejin, Li, Weihua, Li, Hui, Yin, Yuehui, Tao, Guizhou, Yang, Ping, Chen, Yingmin, He, Shenghu, Wang, Yong, Fu, Guosheng, Li, Xin, Wu, Tongguo, Cheng, Xiaoshu, Yan, Xiaowei, Zhao, Ruiping, Chen, Moshui, Xiong, Longgen, Chen, Ping, Jiao, Yang, Guo, Ying, Xue, Li, Yang, Zhiming, Jadhavm, Praveen, Sarma, Raghava, Kulkarni, Govind, Chandwani, Prakash, Pothiwala, Rasesh Atulbhai, Purayil, Mohanan Padinhare, Chawla, Kamaldeep, Kothiwale, Veerappa Annasaheb, Raghuraman, Bagirath, Vijan, Vinod Madan, Sawhney, Jitendra, Bantwal, Ganapathi, Khan, Aziz, Meena, Ramdhan, Chopada, Manojkumar, Abraham, Sunitha, Bisne, Vikas, Vijayaraghavan, Govindan, Roy, Debabrata, Durgaprasad, Rajashekhar, Shankar, A G Ravi, Kumar, Sunil, Jain, Dinesh, Bhargava, Kartikeya, Kumar, Vinay, Nagamalesh, Udigala Madappa, Rajput, Rajeeve Kumar, Kanamori, Seishu, Yamamoto, Kenichi, Kumagai, Koichiro, Katsuda, Yosuke, Yoshida, Keiki, Toyota, Fumitoshi, Mizuno, Yuji, Misumi, Ikuo, Noguchi, Hiroo, Ando, Shinichi, Suetsugu, Tetsuro, Minamoto, Masahiro, Oda, Hiroyuki, Adachi, Susumu, Chiba, Kei, Norita, Hiroaki, Tsuruta, Makoto, Koyanagi, Takeshi, Yamamoto, Kunihiko, Ando, Hiroshi, Higashi, Takayuki, Okada, Megumi, Azakami, Shiro, Komaki, Shinichiro, Kumeda, Kenshi, Murayama, Takashi, Matsumura, Jun, Oba, Yurika, Sonoda, Ryuji, Goto, Kazuo, Minoda, Kotaro, Haraguchi, Yoshikuni, Suefuji, Hisakazu, Miyagi, Hiroo, Kato, Hitoshi, Nakamura, Tsugihiro, Nakamura, Tadashi, Nandate, Hidekazu, Zaitsu, Ryuji, Fujiura, Yoshihisa, Yoshimura, Akira, Numata, Hiroyuki, Ogawa, Jun, Kamogawa, Yasuyuki, Murakami, Kinshiro, Wakasa, Yutaka, Yamasawa, Masanori, Maekawa, Hiromitsu, Abe, Sumihisa, Kihara, Hajime, Tsunoda, Satoru, Saito, Katsumi, Tachibana, Hiroki, Oba, Ichiro, Kuwahata, Takashi, Higa, Satoshi, Gushiken, Masamichi, Eto, Takuma, Chibana, Hidetoshi, Fujisawa, Kazuaki, Shiga, Yuhei, Sumi, Hirokuni, Nagatomo, Toshihisa, Atsuchi, Yoshihiko, Nagoshi, Toshiro, Sanno, Kazuhisa, Hoshino, Fumihiro, Yokota, Naoto, Kameko, Masahiro, Tabuchi, Toshifumi, Ishizawa, Munesumi, Fujiura, Yoshitake, Ikeda, Daisuke, Seto, Taku, Iwao, Tetsu, Ishioka, Norio, Oshiro, Koichi, Tsuchida, Keizo, Hatori, Yutaka, Takeuchi, Motoshi, Takezawa, Hiroto, Nagano, Shinjiro, Iwaki, Masaaki, Nakamura, Yuichiro, Miyamoto, Naomasa, Taguchi, Toshifumi, Ashida, Ko, Yoshizawa, Naoto, Agata, Jun, Matsukawa, Seishiro, Arasaki, Osamu, Fukuoka, Shuji, Murakami, Hirofumi, Mishima, Kazuya, Hata, Yoshiki, Sakuma, Ichiro, Obunai, Kotaro, Takamura, Ichiro, Akutsu, Mitsuyuki, Unoki, Toshihide, Go, Yoshinori, Ikemura, Makoto, Morii, Shoji, Marusaki, Shigeru, Doi, Hideo, Tanaka, Mitsuru, Kusumoto, Takaaki, Kakinoki, Shigeo, Ogurusu, Chiga, Murata, Kazuya, Shimoyama, Masaki, Nakatsuka, Masami, Kitami, Yutaka, Nakamura, Yoichi, Oda, Hiroshi, Oyama, Rikimaru, Ageta, Masato, Mita, Teruaki, Nagao, Kazuhiko, Mito, Takafumi, Minami, Junichi, Abe, Mitsunori, Fujii, Masako, Okawa, Makoto, Fujito, Tsuneo, Taniguchi, Toshiya, Ko, Tenei, Kubo, Hiroshi, Imamaki, Mizuho, Akiyama, Masahiro, Ueda, Takashi, Odakura, Hironori, Inagaki, Masahiko, Katsube, Yoshiki, Nakata, Atsuyuki, Tomimoto, Shinobu, Shibuya, Mitsuhiro, Nakano, Masayuki, Ito, Kenichiro, Matsuta, Masahiro, Ishiguro, Motoyuki, Minagawa, Taro, Wada, Masamichi, Mukawa, Hiroaki, Mizuguchi, Masato, Okuda, Fumio, Kimura, Teruaki, Taga, Kuniaki, Techigawara, Masaaki, Igarashi, Morio, Watanabe, Hiroshi, Seo, Toshihiko, Hiramitsu, Shinya, Hosokawa, Hiroaki, Hoshiai, Mitsumoto, Hibino, Michitaka, Miyagawa, Koichi, Horie, Hideki, Sugishita, Nobuyoshi, Shiga, Yukio, Soma, Akira, Neya, Kazuo, Yoshida, Tetsuro, Akahane, Kunio, Adachi, Sen, Takanaka, Chiei, Matsui, Saori, Kanda, Hirofumi, Kaneko, Masanori, Nagasaka, Shiro, Taguchi, Atsushi, Toru, Shuta, Saito, Kazuyuki, Miyashita, Akiko, Sasaguri, Hiroki, Nariyama, Jin, Hatsuno, Taketo, Iwase, Takash, Sato, Kazuki, Kawai, Kazuya, Kotani, Tomobumi, Tsuji, Tsuyoshi, Sakai, Hirosumi, Nishino, Kiyoshi, Ikeda, Kenichi, Maeda, Kazuo, Shinozuka, Tomohiro, Inoue, Takeshi, Kawakami, Koichi, Kitazumi, Hiromichi, Takagi, Tsutomu, Hamaoka, Mamoru, Kojima, Jisho, Sasaki, Akitoshi, Tsuchiya, Yoshihiro, Betsuyaku, Tetsuo, Higuchi, Koji, Honda, Masaaki, Hasegawa, Koichi, Baba, Takao, Mineoi, Kazuaki, Koeda, Toshihiko, Hirasawa, Kunihiko, Kumazaki, Toshihide, Nakagomi, Akira, Otaki, Eiji, Shindo, Takashi, Hirayama, Hiroyoshi, Sugimoto, Chikako, Yamagishi, Takashi, Mizuguchi, Ichiro, Sezaki, Kazunori, Niwa, Isamu, Takenaka, Ken, Iiji, Osamu, Taya, Koichi, Kitazawa, Hitoshi, Ueda, Samu, Kakuda, Hirokazu, Ono, Takuya, Oriso, Seizo, Kamata, Junya, Nanke, Toshihiko, Maeda, Itaru, Matsuura, Yoshifusa, Teragawa, Hiroki, Maruyama, Yasuyuki, Takei, Kazuo, Horie, Hajime, Kito, Tetsutaro, Asano, Hiroshi, Matsushita, Koji, Nakamura, Masaichi, Washizuka, Takashi, Yoshida, Tomoki, Sawano, Masato, Arima, Shinichi, Arai, Hidekazu, Shinohara, Hisanori, Takai, Hiroyuki, Furukawa, Nobufusa, Ota, Akira, Yamamoto, Kentaro, Aoki, Kenji, Yamamoto, Taku, Kasai, Takeaki, Suzuki, Shunji, Suzuki, Shu, Shibata, Nitaro, Watanabe, Masayuki, Nishihata, Yosuke, Arino, Toru, Okuyama, Masaki, Wakiyama, Tetsushi, Kato, Tomoko, Sasagawa, Yasuo, Tana, Takeshi, Hayashi, Yoshihito, Hirota, Shinichi, Abe, Yukihiko, Saito, Yoshihiro, Uchiyama, Hirohide, Takeda, Hiroshi, Ono, Hiroshi, Tohyo, Shuichi, Hanazono, Naoto, Miyajima, Seiichi, Shimono, Hisashi, Aoyama, Takuma, Shozawa, Yasunobu, Niijima, Yawara, Murai, Osamu, Inaba, Hideko, Nomura, Katsumasa, Nozoe, Masatsugu, Suzuki, Kazuo, Furukawa, Toshiyuki, Shiraiwa, Toshihiko, Ito, Nobuhisa, Nagai, Shunichi, Sato, Kiyoharu, Nakahara, Shiro, Shimoyama, Yujin, Ohara, Naoko, Kozuka, Teruhiko, Okita, Hideaki, Endo, Masato, Goto, Tsutomu, Hirose, Makoto, Nagata, Emiko, Nakanishi, Noriyuki, Mori, Toshizumi, Seki, Shuichi, Okamoto, Katsuhiro, Moriai, Osamu, Emura, Yoko, Fukuda, Tsuyoshi, Date, Haruhiko, Kawakami, Shuichi, Nagai, Sho, Ueyama, Yuya, Fudo, Tetsuro, Imaizumi, Mitsuru, Ogawa, Takuo, Take, Shunsuke, Ikeda, Hideo, Nishioka, Hiroaki, Sakamoto, Norihiko, Ikeoka, Kiyomitsu, Wakaki, Nobuo, Abe, Masatake, Doiuchi, Junji, Kira, Tetsuya, Tada, Masato, Tsuzaki, Ken, Miura, Naoya, Fujisawa, Yasuaki, Furumoto, Wataru, Suzuki, Susumu, Fujisawa, Akinori, Nakamura, Ryosai, Komatsu, Hiroyasu, Fujiki, Rei, Kawano, Shuichi, Nishizawa, Keijiro, Kato, Yoji, Azuma, Junya, Yasui, Kiyoshi, Amano, Toshio, Sekine, Yasuhiro, Honzawa, Tatsuo, Koshibu, Yuichiro, Sakamoto, Yasuhide, Seta, Yukihiro, Miyaguchi, Shingo, Morishita, Kojuro, Samejima, Yasuko, Sasaki, Toyoshi, Iseki, Fumiko, Kobayashi, Toshiyuki, Kano, Hiroshi, Kim, Jaeyoung, Yamaguchi, Hiroshi, Takagi, Yoichi, Pearce, Yoko Onuki, Suzuki, Yasuyuki, Fukui, Takayuki, Nakayama, Toru, Kanai, Hideaki, Kawano, Yoshiyuki, Ino, Tetsuji, Miyoshi, Hironori, Miyamoto, Yasufumi, Shigekiyo, Masahito, Ono, Shimato, Okamoto, Yutaka, Ubukata, Satoshi, Kodera, Kojiro, Oriuchi, Tatsuo, Matsumoto, Naoki, Inagaki, Koichi, Iseki, Atsushi, Yoshida, Tomohiro, Goda, Toshihiro, Katsuki, Tsukasa, Sato, Atsushi, Mori, Etsuo, Tsubokura, Toshio, Shudo, Hiroshi, Fujimoto, Shunichi, Katsuya, Tomohiro, Furukawa, Yoshiyuki, Hosokawa, Hiroshi, Narumi, Jun, Yamamoto, Kiichiro, Owari, Masaki, Inakura, Takuya, Anno, Takafumi, Shirakawa, Kazuyuki, Ching, Chi Keong, Foo, David, Wong, Kelvin, Yuyang, Tan, Park, Hui Nam, Kim, Woo-Shik, Lee, HyeYoung, Jang, Sung-Won, Kim, Dae Hyeok, Kim, Jun, Ryu, DongRyeol, Shim, Jaemin, Kim, Dae-Kyeong, Choi, Dong Ju, Oh, Yong Seog, Cho, Myeong-Chan, Kim, Hack-Lyoung, Jeon, Hui-Kyung, Shin, Dong-Gu, Park, Sang Weon, Park, Hoon Ki, Han, Sang-Jin, Sung, Jung Hoon, Park, Hyung-Wook, Nam, Gi-Byoung, On, Young Keun, Lim, Hong Euy, Kwak, JaeJin, Cha, Tae-Joon, Hong, Taek Jong, Park, Seong Hoon, Yoon, Jung Han, Kim, Nam-Ho, Kim, Kee-Sik, Jung, Byung Chun, Hwang, Gyo-Seung, Kim, Chong-Jin, Rungaramsin, Sakda, Katekangplu, Peerapat, Khunrong, Porames, Bunyapipat, Thanita, Wongcharoen, Wanwarang, Kaewsuwanna, Pinij, Siriwattana, Khanchai, Tiyanon, Waraporn, Pattanaprichakul, Supalerk, Likittanasombat, Khanchit, Cholsaringkarl, Doungrat, Boonyapisit, Warangkana, Cheewatanakornkul, Sirichai, Silaruks, Songkwan, Hutayanon, Pisit, Chawanadelert, Seksan, Chattranukulchai, Pairoj, Chatlaong, Boonsert, Santanakorn, Yingsak, Kanokphatcharakun, Khompiya, Mongkolwongroj, Piya, Jai-Aue, Sasivimon, Komson, Ongkarn, Altun, Armagan, Aydinlar, Ali, Topsakal, Ramazan, Ongen, Zeki, Acikel, Sadik, Sahin, Durmus Yildiray, Yilmaz, Ozcan, Yilmaz, Mehmet Birhan, Pekdemir, Hasan, Demir, Mesut, Sucu, Murat, Sahiner, Levent, Ersanli, Murat, Okuyan, Ertugrul, Aras, Dursun, Rolandi, Florencia, Ingaramo, Adrian Cesar, Sambadaro, Gustavo Alberto, Caputi, Vanina Fernandez, Luciardi, Hector, Berman, Sofia Graciela, Dragotto, Pablo, Kleiban, Andres Javier, Centurion, Nestor, Guerrero, Rodolfo Andres Ahuad, Di Paola, Leonel Adalberto, Dran, Ricardo Dario, Egido, Javier, Fosco, Matias Jose, Sinisi, Victor Alfredo, Cartasegna, Luis Rodolfo, Vilamajo, Oscar Gomez, Ramos, Jose Luis, Sassone, Sonia, Zapata, Gerardo, Conde, Diego, Giacomi, Guillermo, Fernandez, Alberto Alfredo, Berli, Mario Alberto, Ferroni, Fabian, Filho, Dário Celestino Sobral, Jaber, Jefferson, Armaganijan, Luciana Vidal, Costantini, Costantino Roberto Frack, Steffens, André, de Souzaem, Weimar Kunz Sebba Barroso, de Souza Neto, João David, Ribeiro, José Márcio, Teixeira, Marcelo Silveira, Rossi, Paulo, Pires, Leonardo, Moreira, Daniel, Jorge, José Carlos Moura, Filho, Adalberto Menezes Lorga, Bodanese, Luiz, Montera, Marcelo Westerlund, Del Carlo, Carlos Henrique, Saad, Jamil Abdalla, Alves da Costa, Fernando Augusto, Lopes, Renato, de Araújo, Gilson Roberto, Manenti, Euler Roberto, Saraiva, Jose Francisco Kerr, Braga, João Carlos Ferreira, Negri, Alexandre, Moncada, Carlos, Precoma, Dalton, Roquette, Fernando, Reis, Gilmar, Ramos Filho, Roberto Álvaro, Figueiredo, Estêvão Lanna, Botelho, Roberto Vieira, da Fontoura Tavares, Cláudio Munhoz, Finimundi, Helius Carlos, Kochi, Adriano, França, César Cássio Broilo, Alban, Fábio, Rosito, Guido Bernardo Aranha, Junior, João Batista de Moura Xavier Moraes, Tumelero, Rogério Tadeu, Maia, Lilia, de Almeida, Roberto Simões, do Carmo Borges, Ney Carter, Gomes Ferreira, Luís Gustavo, Corbalán, Ramón, Fernandez, Benjamin Aleck Joseh Stockins, Montecinos, Humberto, Lanas, Fernando, Gómez, Martín Larico, Astudillo, Carlos, Conejeros, Carlos, Cuevas, Patricio Marin, Forero, Alejandro, Gutiérrez, Claudio Bugueño, Aguilar, Juan, Cardenas, Sergio Potthoff, Eggers, German, Houzvic, Cesar, Rey, Carlos, Arriagada, Germán, Vilches, Gustavo Charme, Illescas Diaz, Jesus Jaime, Cantu, Raul Leal, Ramos Zavala, Maria Guadalupe, Jardines, Ricardo Cabrera, Zavaleta, Nilda Espinola, Rosas, Enrique Lopez, Llamas Esperón, Guillermo Antonio, Pozas, Gerardo, Muñoz, Ernesto Cardona, Hernandez, Norberto Matadamas, Rendon, Adolfo Leyva, Hernandez, Norberto Garcia, de los Rios Ibarra, Manuel, Carrillo, Luis Ramon Virgen, Villezca, David Lopez, Herrera, Carlos Hernandez, Lopez Prieto, Juan Jose, Rodriguez, Rodolfo Gaona, Espinosa, Efrain Villeda, Martinez, David Flores, Barcena, Jose Velasco, Fierro, Omar Fierro, Briones, Ignacio Rodriguez, Leiva Pons, Jose Luis, Lopez, Humberto Alvarez, Ruiz, Rafael Olvera, Brito, Carlos Gerardo Cantu, Valenzuela, Eduardo Julian Jose Roberto Chuquiure, Sanchez, Roxana Reyes, Bazzoni Ruiz, Alberto Esteban, Lopez Ruiz, Oscar Martin, Nava, Roberto Arriaga, Morales Cerda, Jesus David, Campos, Pedro Fajardo, Gonzalez, Mario Benavides, Lenz, Kurt, Hagn, Claus, Foechterle, Johannes, Drexel, Heinz, Huber, Kurt, Podczeck-Schweighofer, Andrea, Winkler, Michael, Schneeweiss, Bruno, Gegenhuber, Alfons, Lang, Wilfried, Eichinger-Hasenauer, Sabine, Kaserer, Peter, Sykora, Josef, Rasch, Heribert, Strohmer, Bernhard, Capiau, Luc, Vervoort, Geert, Wollaert, Bart, Hollanders, Geert, Vercammen, Jan, Faes, Dirk, Balthazar, Yohan, Delforge, Marc, Xhaet, Olivier, Striekwold, Harry, Thoeng, John, Hermans, Kurt, Mairesse, Georges, Anné, Wim, Blankoff, Ivan, Beutels, Michel, Verstraete, Stefan, Vandergoten, Peter, Purnode, Philippe, Godart, Pascal, Boussy, Tim, Desfontaines, Philippe, Heyse, Alex, Voet, Joeri, De Wolf, Axel, Zidkova, Eva, Spacek, Rudolf, Machova, Vilma, Ludka, Ondrej, Olsr, Josef, Kotik, Lubos, Racz, Blazej, Ferkl, Richard, Hubac, Jan, Kotik, Ilja, Monhart, Zdenek, Burianova, Hana, Jerabek, Ondrej, Pisova, Jana, Petrova, Iveta, Dedek, Vratislav, Honkova, Michaela, Podrazil, Petr, Reichert, Petr, Spinar, Jindrich, Novak, Miroslav, Durdil, Vaclav, Plocova, Katarina, Lastuvka, Jiri, Nielsen, Jørn, Husted, Steen, Dominguez, Helena, Hintze, Ulrik, Rasmussen, Søren, Sygehus, Næstved, Bremmelgaard, Arne, Markenvard, John, Børger, Jan, Solgaard, Jorgen, Eriksen, Ebbe, Løkkegaard, Thomas, Bruun, Michael, Mertz, Jacob, Schou, Morten, Olsen, Michael, Airaksinen, K E Juhani, Paganelli, Franck, Ohayon, Joël, Casassus, Frédéric, Galinier, Michel, Gottwalles, Yannick, Loiselet, Philippe, Muller, Jean-Joseph, Koujan, Mohamed Bassel, Marquand, André, Destrac, Sylvain, Piot, Olivier, Delarche, Nicolas, Cebron, Jean-Pierre, Guenoun, Maxime, Guedj-Meynier, Dominique, Lokesh, A G, Zuber, Mathieu, Amarenco, Pierre, Ellie, Emmanuel, Kadouch, James, Fournier, Pierre-Yves, Huberman, Jean-Pierre, Lemaire, Nestor, Rodier, Gilles, Vandamme, Xavier, Sibon, Igor, Neau, Jean-Philippe, Mahagne, Marie Hélène, Mielot, Antoine, Bonnefoy, Marc, Churet, Jean-Baptiste, Navarre, Vincent, Sellem, Frederic, Monniot, Gilles, Boyes, Jean-Paul, Doucet, Bernard, Martelet, Michel, Obadia, Désiré, Crousillat, Bernard, Mouallem, Joseph, Bearez, Etienne, Brugnaux, Jean Philippe, Fedorowsky, Alain, Nazeyrollas, Pierre, Berneau, Jean-Baptiste, Chemin, Frédéric, Schellong, Sebastien, Koeniger, Georg, Kopf, Andreas, Gerbaulet, Uwe, Kellner, Bernd-Thomas, Schaefer, Thomas, Purr, Jan, Eißfeller, Enno, Zauzig, Heinz-Dieter, Riegel, Peter, Axthelm, Christoph, Heinz, Gerd-Ulrich, Menke, Holger, Pustelnik, Andreas, Zutz, Stefan, Eder, Wolfgang, Rehling, Guenter, Glatzel, Dirk, Ludwig, Norbert, Sandow, Petra, Wiswedel, Henning, Wildenauer, Cosmas, Schoen, Steffen, Schwarz, Toralf, Babyesiza, Adyeri, Kropp, Maximilian, Zimny, Hans-Hermann, Kahl, Friedhelm, Caspar, Andreas, Omankowsky, Sabine, Laessig, Torsten, Hartmann, Hermann-Josef, Lehmann, Gunter, Bindig, Hans-Walter, Hergdt, Gunter, Reimer, Dietrich, Hauk, Joachim, Michel, Holger, Dres, Praxis, Erdle, Werner, Dorsch, Wilfried, Dshabrailov, Janna, Rapp, Karl-Albrecht, Vormann, Reinhold, Mueller, Thomas, Mayer, Peter, Horstmeier, Uwe, Eissing, Volker, Hey, Heinz, Leuchtgens, Heinz, Lilienweiss, Volker, Mueller, Heiner, Schubert, Christian, Lauer, Herrmann, Buchner, Thomas, Brauer, Gunter, Kamin, Susanne, Mueller, Karsten, Baumbach, Sylvia, Abdel-Qader, Muwafeg, Ebert, Hans-Holger, Schwencke, Carsten, Bernhardt, Peter, Karolyi, Laszlo, Sievers, Britta, Haverkamp, Wilhelm, Roehnisch, Jens-Uwe, Vertes, Andras, Szantai, Gabor, Matoltsy, Andras, Kanakaridisz, Nikosz, Boda, Zoltan, Kis, Erno, Gaszner, Balazs, Juhasz, Ferenc, Juhasz, Gizella, Kancz, Sandor, Laszlo, Zoltan, May, Zsolt, Merkely, Bela, Noori, Ebrahim, Habon, Tamas, Polgar, Peter, Szalai, Gabriella, Vangel, Sandor, Nagy, Andras, Engelthaler, Gabriella, Ferenczi, Judit, Egyutt, Mihaly, Martini, Giuliana, Cristina, Leone Maria, Tiraferri, Eros, Santoro, Rita, Testa, Sophie, Di Minno, Giovanni, Moia, Marco, Caimi, Teresa Maria, Tessitori, Maria, Cappelli, Roberto, Poli, Daniela, Quintavalla, Roberto, Cosmi, Franco, Fanelli, Raffaele, Oriana, Vincenzo, Reggio, Raffaele, Santi, Roberto, Pancaldi, Leonardo, De Cristofaro, Raimondo, Guazzaloca, Giuliana, De Blasio, Angelo, Uriate, Jorge Salerno, Lillo, Flavia, Pogliani, Enrico Maria, Bilo, Grzegorz, Accogli, Michele, Mariani, Antonio, Feola, Mauro, Raisaro, Arturo, Fattore, Luciano, Mauric, Andrea, Germini, Fabrizio, Tedeschi, Luca, Settimi, Maria, Nicoli, Sergio, Ricciarini, Paolo, Argena, Antonio, Ronchini, Paolo, Bulla, Claudio, Tradati, Filippo, Volpe, Massimo, D’Avino, Maria, Bongiorni, Maria Grazia, Severi, Silva, Capucci, Alessandro, Lodigiani, Corrado, Salomone, Enrico, Serviddio, Gaetano, Tondo, Claudio, Golino, Paolo, Mazzone, Carmine, Iacopino, Saverio, ten Cate, Hugo, Ruiter, J H, Lucassen, Andreas, Adriaansen, Henk, Bongaerts, Maarten, Pieterse, Mathijs, van Guldener, Coen, Herrman, Johannes, Nierop, S H K P R, Hoogslag, Pieter, Hermans, Walter, Groenemeijer, B E, Terpstra, W, Buiks, Cees, Boersma, L V A, Berge, Eivind, Sirnes, Per Anton, Gjertsen, Erik, Hole, Torstein, Erga, Knut, Hallaråker, Arne, Skjelvan, Gunnar, Østrem, Anders, Ghezai, Beraki, Svilaas, Arne, Christersson, Peter, Øien, Torbjørn, Henrichsen, Svein Høegh, Otterstad, Jan Erik, Berg-Johansen, Jan, Gieroba, Andrzej, Biedrzycka, Malgorzata, Ogorek, Michal, Wozakowska-Kaplon, Beata, Loboz-Grudzien, Krystyna, Supinski, Wieslaw, Kuzniar, Jerzy, Zaluska, Roman, Hiczkiewicz, Jaroslaw, Swiatkowska-Byczynska, Lucyna, Kucharski, Lech, Gruchala, Marcin, Minc, Piotr, Olszewski, Maciej, Kania, Grzegorz, Krzciuk, Malgorzata, Lajkowski, Zbigniew, Ostrowska-Pomian, Bozenna, Lewczuk, Jerzy, Zinka, Elzbieta, Karczmarczyk, Agnieszka, Chmielnicka-Pruszczynska, Malgorzata, Wozniak-Skowerska, Iwona, Opolski, Grzegorz, Bronisz, Marek, Ogorek, Marcin, Glanowska, Grazyna, Ruszkowski, Piotr, Skonieczny, Grzegorz, Sciborski, Ryszard, Okopien, Boguslaw, Kukla, Piotr, Galbas, Krzysztof, Cymerman, Krzysztof, Jurowiecki, Jaroslaw, Miekus, Pawel, Myszka, Waldemar, Mazur, Stanislaw, Lysek, Roman, Baszak, Jacek, Rusicka-Piekarz, Teresa, Raczak, Grzegorz, Domanska, Ewa, Nessler, Jadwiga, Lesnik, Jozef, Eltishcheva, Vera, Libis, Roman, Kamalov, Gadel, Belenky, Dmitry, Egorova, Liudmila, Khokhlov, Alexander, Yakupov, Eduard, Zateyshchikov, Dmitry, Barbarash, Olga, Miller, Olga, Mazur, Evgeniy, Zrazhevskiy, Konstantin, Novikova, Tatyana, Moiseeva, Yulia, Polkanova, Elena, Sobolev, Konstantin, Rossovskaya, Maria, Shapovalova, Yulia, Kolesnikova, Alla, Nikolaev, Konstantin, Zemlianskaia, Oksana, Zateyshchikova, Anna, Kostenko, Victor, Popov, Sergey, Poltavskaya, Maria, Edin, Anton, Aleksandrova, Elena, Drapkina, Oksana, Vishnevsky, Alexander, Nagibovich, Oleg, Chizhov, Petr, Rachkova, Svetlana, Sergeev, Mikhail, Kurylo, Borys, Ushakov, Alexey, Vinolas, Xavier, Garcia, Pere Alvarez, Lopez Fernandez, Maria Fernanda, Sanchez, Luis Tercedor, Iparraguirre, Salvador Tranche, Monserrat, Pere Toran, Contreras, Emilio Marquez, Rafecas, Jordi Isart, Carrasco, Juan Motero, Pavia, Pablo Garcia, Pajuelo, Casimiro Gomez, Rincon Diaz, Luis Miguel, Iglesias Alonso, Luis Fernando, Ruiz, Angel Grande, Klein, Jordi Merce, Gonzalez Juanatey, Jose Ramon, Collado, Ines Monte, Piquero, Herminia Palacin, Cuixart, Carles Brotons, Escobar, Esther Fernandez, Bayo i Llibre, Joan, Vicente, Cecilia Corros, Gutierrez, Manuel Vida, Gonzalo, Francisco Epelde, Almeida Fernandez, Carlos Alexandre, Navarro, Encarnacion Martinez, Alia, Juan Jose Montero, Gonzalez, Maria Barreda, Oliva, Maria Angels Moleiro, Sanmartin, Jose Iglesias, Gonzalez, Mercedes Jimenez, Alvarez, Maria del Mar Rodriguez, Melenchon, Juan Herreros, Vera, Tomas Ripoll, Navarro, Manuel Jimenez, Caamano, Maria Vazquez, Arcocha Torres, Maria Fe, Gomez, Gonzalo Marcos, Romo, Andres Iniguez, Prieto Diaz, Miguel Angel, Rosenqvist, Mårten, Wirdby, Alexander, Lindén, Jan, Henriksson, Kerstin, Elmersson, Micael, Egilsson, Arnor, Börjesson, Ulf, Svärd, Gunnar, Liu, Bo, Lindh, Anders, Olsson, Lars-Bertil, Gustavsson, Mikael, Andersson, Lars, Benson, Lars, Bothin, Claes, Hajimirsadeghi, Ali, Martinsson, Björn, Ericsson, Marianne, Ohlsson, Åke, Lindvall, Håkan, Svensson, Peter, Thörne, Katarina, Händel, Hans, Platonov, Pyotr, Bernsten, Fredrik, Timberg, Ingar, Crisby, Milita, Karlsson, Jan-Erik, Andersson, Agneta, Malmqvist, Lennart, Engdahl, Johan, Thulin, Jörgen, Hot-Bjelak, Aida, Jensen, Steen, Stalby, Per, Debrunner, Johann, Beer, Juerg H, Shah, Dipen, Rudyk, Iurii, Tseluyko, Vira, Karpenko, Oleksandr, Zhurba, Svitlana, Kraiz, Igor, Parkhomenko, Oleksandr, Kupnovytska, Iryna, Seredyuk, Nestor, Mostovoy, Yuriy, Ushakov, Oleksiy, Koval, Olena, Kovalskiy, Igor, Svyshchenko, Yevgeniya, Sychov, Oleg, Stanislavchuk, Mykola, Yagensky, Andriy, Tykhonova, Susanna, Fushtey, Ivan, Murdoch, Will, Chauhan, Naresh, Goodwin, Daryl, Lumley, Louise, Patel, Ramila, Saunders, Philip, Wong, Bennett, Cameron, Alex, Patel, Niranjan, Jhittay, P, Ross, Andrew, Kainth, M S, Ladha, Karim, Douglas, Kevin, Pickavance, Gill, McDonnell, Joanna, Handscombe, Laura, Gooding, Trevor, Wagner, Helga, Bradshaw, Colin, Bromham, Catherine, Jones, Kevin, Suryani, Shoeb, Coates, Richard, Sarai, Bhupinder, Willcock, W, Sircar, S, Cairns, John, Gilliand, A, Bilas, Roman, Strieder, E, Hutchinson, Peter, Wakeman, Anne, Stokes, Michael, Kirby, Graham, Vishwanathan, Bhaskhar, Bird, Nigel, Evans, Paul, Clark, M, Bisatt, John, Litchfield, Jennifer, Fisher, E, Fooks, Tim, Kelsall, Richard, Paul, Neil, Alborough, Elizabeth, Aziz, Michael, Ramesh, C, Wilson, Pete, Franklin, Simon, Fairhead, Sue, Thompson, Julian, Chowan, Hasan, Taylor, Gary, Tragen, Dawn, Parfitt, Matt, Seamark, Claire, Paul, Carolyn, Richardson, Mark, Jefferies, Angus, Sharp, Helen, Jones, Hywel, Giles, Claire, Bramley, Matthew, Williams, Philip, Aldegather, Jehad, Wetherell, Simon, Lumb, William, Evans, Phil, Scouller, Frances, Macey, Neil, Rogers, Stephen, Stipp, Yvette, West, Richard, Pinney, Philip, Wadeson, Paul, Matthews, John, Pandya, Preeti, Gallagher, Andrew, Railton, T, Davies, Emyr, McClure, Jonathan, Jacobs, Marc, Hutton, Claire, Thompson, R, Sinha, Bijoy, Butter, Keith, Barrow, Susan, Little, Helen, Russell, David, Choudhary, Ulka, Haq, Ikram, Ainsworth, Paul, Jones, Claire, Weeks, Phil, Eden, Jane, Gibbons, Lisa, Glencross, Janet, MacLeod, Alison, Poland, K, Mulolland, Conor, Warke, A, Conn, Paul, Burns, D, Smith, R, Kamath, R, Webster, Jonathan, Hodgins, Ian, Vercoe, Stephen, Roome, Paul, Pinnock, Hilary, Patel, Jayesh, Ali, Amar, Hart, Nigel, Davies, Richard, De-Sousa, Nigel, Neden, Catherine, Danielsen, Mark, Sharma, Purnima, Galloway, Sophia, Hawkins, Charlotte, Oliver, Raife, Aylward, Martin, Pattni, Mira, Irvine, Gordon, Ahmad, Shahid, Rothwell, Catherine, Choudhary, Fiaz, Khalaque, Sabrina, Short, Stephanie, Peters, Sharon, Coulson, Warwick, Roberts, Neil, Butler, Amy, Coates, Steven, Ward, Ben, Jackson, Daniel, Walton, Steve, Shepherd, Diane, Wong, Toh, Boon, Mark, Deacon, Melanie, Cornelius, David, Davies, Sarah, Frankel, Ben, Hargreaves, Nick, Choi, Henry, Sumner, Jon, Myhill, Tim, Estifanos, Salah, Geatch, Diane, Wilkinson, Justin, Veale, Richard, Forshaw, Karen, Hirst, Rob, Zaman, Kashif, Liley, Catherine, Wastling, Rebecca, McEleny, Paul, Beattie, Andre, Cooke, Philip, Wong, Mike, Pugsley, Mark, Dooldeniya, Chaminda, Rogers, Greg, Bennett, James, Jacobs, Polly, Muvva, Rajesh, Adam, Matthew, Fox, Robin, Thomas, Nicolas, Cartwright, Simon, Reed, Rory, Randfield, Simon, A’Court, Christine, Flynn, Ann, Halpin, Andrew, Dobson, Simon, Lomax, Louise, Nadaph, Minnal, Munro, Iain, Goram, Jane, Stoddart, Helen, Simmons, Phil, Shewring, John, Bowen-Simpkins, Emma, Rickenbach, Mark, Blenkhorn, Adam, Singh, Bhuwanendu, Astridge, Penny, van Gaal, William, Abhayaratna, Walter, Thomson, Philip, Lehman, Ron, Kilian, Jens, Coulshed, David, Catanchin, Andrei, Colquhoun, David, Kiat, Hosen, Eccleston, David, French, John, Ayres, Bronte, Blombery, Peter, Phan, Thanh, Rogers, James, O’Donnell, David, Bae, Sang Cheol, Carroll, Patrick, Starmer, Greg, Arstall, Margaret, Binnekamp, Maurits, Lee, Astin, Luton, Robert, Gupta, Milan, Pandey, Amritanshu Shekhar, Cheung, Stephen, Leader, Rolland, Beaudry, Philippe, Ayala-Paredes, Félix, Berlingieri, Joseph, Heath, John, Poirier, Germain, du Preez, Miranda, Schweitzer, Bradley, Nadeau, Reginald, Dhillon, Ripple, Hruczkowski, Tomasz, Lavoie, Andrea, Parkash, Ratika, Cha, James, Coutu, Benoit, MacDonald, Paul, Ramjattan, Brian, Bonet, Jorge, Vizel, Saul, Angaran, Paul, Fikry, Sameh, Mowafy, Ahmed, Katta, Azza, Tawfik, Mazen, Nawar, Moustafa, Sobhy, Mohamed, Abou Seif, Seif Kamal, Khairy, Tarek, El-Aziz, Ahmed Abd, Taha, Nasser, Reda, Ashraf, Elbahry, Atef, Setiha, Mohamed, El Din, Mohamed Gamal, Elkhadem, Magdi, El-Etreby, Adel, Kettles, David, Bayat, Junaid, Siebert, Heidi, Horak, Adrian, Kelfkens, Ynez, Garda, Riaz, Pillay, Thayabran, Guerra, Michele, van Zyl, Louis, Theron, Hendrik, Murray, Andrew, Louw, Rikus, Greyling, Deon, Mntla, Pindile, Ismail, Siddique, Ahmed, Fayzal, Engelbrecht, Johannes, Maharajh, Shambu, Oosthuysen, Wessel, Loghdey, Rehana, Ueckermann, Veronica, Al Naeemi, Abdullah, Yousef, Ghazi, Bazargani, Nooshin, AlOmairi, Munther, Maruthanayagam, Rajan, Singh, Rupesh, Naguib, Ahmed, Ibrahim, Mohamed, Agrawal, Amrish, Nathani, Mukesh, Esheiba, Ehab M, Wassef, Adel, Gupta, Rajeev, Cox, Michael, Beach, Scott, Duffy, Peter, Falkowski, Stephen, Ferrick, Kevin, Franco, Miguel, Kutayli, W Michael, Quick, Annette, Sharma, Niraj, Wilson, Vance, Miller, Stephen, Alberts, Mark, Blumberg, Edwin, Canosa, Roddy, Gutowski, Ted, Ison, Rodney, Garcia, Jorge, Mullen, Paul, Noveck, Howard, Rama, Pamela, Reddy, Rajneesh, Williams, Marcus, Nishijima, Daniel, Ferdinand, Keith, Haque, Ihsan, Mendelson, Robert, Pitta, Sridevi, Theodoro, Daniel, Treasure, Charles, Moustafa, Moustafa, Cader, Cas, Pharr, Walter, Oropallo, Alisha, Platt, George, Gujral, Jaspal, Welker, James, and Koura, Firas
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Electric Countershock ,Therapeutics ,Cardioversion ,Lower risk ,Cause of Death ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Prospective Studies ,Registries ,Propensity Score ,Stroke ,Aged ,Proportional Hazards Models ,business.industry ,Proportional hazards model ,Research ,Anticoagulant ,Hazard ratio ,Atrial fibrillation ,General Medicine ,Middle Aged ,medicine.disease ,Propensity score matching ,Cardiology ,Female ,business ,RC - Abstract
OBJECTIVE To investigate the clinical outcomes of patients who underwent cardioversion compared with those who did not have cardioverson in a large dataset of patients with recent onset non-valvular atrial fibrillation. DESIGN Observational study using prospectively collected registry data (Global Anticoagulant Registry in the FIELD-AF-GARFIELD-AF). SETTING 1317 participating sites in 35 countries. PARTICIPANTS 52 057 patients aged 18 years and older with newly diagnosed atrial fibrillation (up to six weeks' duration) and at least one investigator determined stroke risk factor. MAIN OUTCOME MEASURES Comparisons were made between patients who received cardioversion and those who had no cardioversion at baseline, and between patients who received direct current cardioversion and those who had pharmacological cardioversion. Overlap propensity weighting with Cox proportional hazards models was used to evaluate the effect of cardioversion on clinical endpoints (all cause mortality, non-haemorrhagic stroke or systemic embolism, and major bleeding), adjusting for baseline risk and patient selection. RESULTS 44 201 patients were included in the analysis comparing cardioversion and no cardioversion, and of these, 6595 (14.9%) underwent cardioversion at baseline. The propensity score weighted hazard ratio for all cause mortality in the cardioversion group was 0.74 (95% confidence interval 0.63 to 0.86) from baseline to one year follow-up and 0.77 (0.64 to 0.93) from one year to two year follow-up. Of the 6595 patients who had cardioversion at baseline, 299 had a follow-up cardioversion more than 48 days after enrolment. 7175 patients were assessed in the analysis comparing type of cardioversion: 2427 (33.8%) received pharmacological cardioversion and 4748 (66.2%) had direct current cardioversion. During one year follow-up, event rates (per 100 patient years) for all cause mortality in patients who received direct current and pharmacological cardioversion were 1.36 (1.13 to 1.64) and 1.70 (1.35 to 2.14), respectively. OBJECTIVE To investigate the clinical outcomes of patients who underwent cardioversion compared with those who did not have cardioverson in a large dataset of patients with recent onset non-valvular atrial fibrillation. DESIGN Observational study using prospectively collected registry data (Global Anticoagulant Registry in the FIELD-AF-GARFIELD-AF). SETTING 1317 participating sites in 35 countries. PARTICIPANTS 52 057 patients aged 18 years and older with newly diagnosed atrial fibrillation (up to six weeks' duration) and at least one investigator determined stroke risk factor. MAIN OUTCOME MEASURES Comparisons were made between patients who received cardioversion and those who had no cardioversion at baseline, and between patients who received direct current cardioversion and those who had pharmacological cardioversion. Overlap propensity weighting with Cox proportional hazards models was used to evaluate the effect of cardioversion on clinical endpoints (all cause mortality, non-haemorrhagic stroke or systemic embolism, and major bleeding), adjusting for baseline risk and patient selection. RESULTS 44 201 patients were included in the analysis comparing cardioversion and no cardioversion, and of these, 6595 (14.9%) underwent cardioversion at baseline. The propensity score weighted hazard ratio for all cause mortality in the cardioversion group was 0.74 (95% confidence interval 0.63 to 0.86) from baseline to one year follow-up and 0.77 (0.64 to 0.93) from one year to two year follow-up. Of the 6595 patients who had cardioversion at baseline, 299 had a follow-up cardioversion more than 48 days after enrolment. 7175 patients were assessed in the analysis comparing type of cardioversion: 2427 (33.8%) received pharmacological cardioversion and 4748 (66.2%) had direct current cardioversion. During one year follow-up, event rates (per 100 patient years) for all cause mortality in patients who received direct current and pharmacological cardioversion were 1.36 (1.13 to 1.64) and 1.70 (1.35 to 2.14), respectively. CONCLUSION In this large dataset of patients with recent onset non-valvular atrial fibrillation, a small proportion were treated with cardioversion. Direct current cardioversion was performed twice as often as pharmacological cardioversion, and there appeared to be no major difference in outcome events for these two cardioversion modalities. For the overall cardioversion group, after adjustments for confounders, a significantly lower risk of mortality was found in patients who received early cardioversion compared with those who did not receive early cardioversion. STUDY REGISTRATION ClinicalTrials.gov NCT01090362.
- Published
- 2021
41. Association of psychosocial factors with all-cause hospitalizations in patients with atrial fibrillation
- Author
-
Meyre, Pascal B, Springer, Anne, Aeschbacher, Stefanie, Blum, Steffen, Rodondi, Nicolas, Beer, Juerg H, Di Valentino, Marcello, Ammann, Peter, Blum, Manuel, Mathys, Rebecca, Meyer-Zürn, Christine, Bonati, Leo H, Sticherling, Christian, Schwenkglenks, Matthias, Kühne, Michael, Conen, David, Osswald, Stefan, University of Zurich, and Meyre, Pascal B
- Subjects
Male ,Incidence ,Clinical Investigations ,610 Medicine & health ,unplanned hospitalization ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) ,2705 Cardiology and Cardiovascular Medicine ,Hospitalization ,360 Social problems & social services ,Risk Factors ,Atrial Fibrillation ,Humans ,Female ,Prospective Studies ,Registries ,psychosocial factors ,health perception ,Stress, Psychological ,Switzerland ,Aged - Abstract
BACKGROUND A high burden of cardiovascular comorbidities puts patients with atrial fibrillation (AF) at high risk for hospitalizations, but the role of other factors is less clear. HYPOTHESIS To determine the relationship between psychosocial factors and the risk of unplanned hospitalizations in AF patients. METHODS Prospective observational cohort study of 2378 patients aged 65 or older with previously diagnosed AF across 14 centers in Switzerland. Marital status and education level were defined as social factors, depression and health perception were psychological components. The pre-defined outcome was unplanned all-cause hospitalization. RESULTS During a median follow-up of 2.0 years, a total of 1713 hospitalizations occurred in 37% of patients. Compared to patients who were married, adjusted rate ratios (aRR) for all-cause hospitalizations were 1.28 (95% confidence interval [CI], 0.97-1.69) for singles, 1.31 (95%CI, 1.06-1.62) for divorced patients, and 1.02 (95%CI, 0.82-1.25) for widowed patients. The aRRs for all-cause hospitalizations across increasing quartiles of health perception were 1.0 (highest health perception), 1.15 (95%CI, 0.84-1.59), 1.25 (95%CI, 1.03-1.53), and 1.66 (95%CI, 1.34-2.07). No different hospitalization rates were observed in patients with a secondary or primary or less education as compared to patients with a college degree (aRR, 1.06; 95%CI, 0.91-1.23 and 1.05; 95%CI, 0.83-1.33, respectively). Presence of depression was not associated with higher hospitalization rates (aRR, 0.94; 95%CI, 0.68-1.29). CONCLUSIONS The findings suggest that psychosocial factors, including marital status and health perception, are strongly associated with the occurrence of hospitalizations in AF patients. Targeted psychosocial support interventions may help to avoid unnecessary hospitalizations. TRIAL REGISTRATION ClinicalTrials.gov Identifier NCT02105844.
- Published
- 2021
- Full Text
- View/download PDF
42. Association of psychosocial factors with all-cause hospitalizations in patients with atrial fibrillation
- Author
-
Meyre, Pascal B; https://orcid.org/0000-0002-1236-1386, Springer, Anne, Aeschbacher, Stefanie; https://orcid.org/0000-0001-8134-2421, Blum, Steffen, Rodondi, Nicolas, Beer, Juerg H, Di Valentino, Marcello, Ammann, Peter, Blum, Manuel, Mathys, Rebecca, Meyer-Zürn, Christine, Bonati, Leo H, Sticherling, Christian, Schwenkglenks, Matthias, Kühne, Michael, Conen, David, Osswald, Stefan, Meyre, Pascal B; https://orcid.org/0000-0002-1236-1386, Springer, Anne, Aeschbacher, Stefanie; https://orcid.org/0000-0001-8134-2421, Blum, Steffen, Rodondi, Nicolas, Beer, Juerg H, Di Valentino, Marcello, Ammann, Peter, Blum, Manuel, Mathys, Rebecca, Meyer-Zürn, Christine, Bonati, Leo H, Sticherling, Christian, Schwenkglenks, Matthias, Kühne, Michael, Conen, David, and Osswald, Stefan
- Abstract
BACKGROUND A high burden of cardiovascular comorbidities puts patients with atrial fibrillation (AF) at high risk for hospitalizations, but the role of other factors is less clear. HYPOTHESIS To determine the relationship between psychosocial factors and the risk of unplanned hospitalizations in AF patients. METHODS Prospective observational cohort study of 2378 patients aged 65 or older with previously diagnosed AF across 14 centers in Switzerland. Marital status and education level were defined as social factors, depression and health perception were psychological components. The pre-defined outcome was unplanned all-cause hospitalization. RESULTS During a median follow-up of 2.0 years, a total of 1713 hospitalizations occurred in 37% of patients. Compared to patients who were married, adjusted rate ratios (aRR) for all-cause hospitalizations were 1.28 (95% confidence interval [CI], 0.97-1.69) for singles, 1.31 (95%CI, 1.06-1.62) for divorced patients, and 1.02 (95%CI, 0.82-1.25) for widowed patients. The aRRs for all-cause hospitalizations across increasing quartiles of health perception were 1.0 (highest health perception), 1.15 (95%CI, 0.84-1.59), 1.25 (95%CI, 1.03-1.53), and 1.66 (95%CI, 1.34-2.07). No different hospitalization rates were observed in patients with a secondary or primary or less education as compared to patients with a college degree (aRR, 1.06; 95%CI, 0.91-1.23 and 1.05; 95%CI, 0.83-1.33, respectively). Presence of depression was not associated with higher hospitalization rates (aRR, 0.94; 95%CI, 0.68-1.29). CONCLUSIONS The findings suggest that psychosocial factors, including marital status and health perception, are strongly associated with the occurrence of hospitalizations in AF patients. Targeted psychosocial support interventions may help to avoid unnecessary hospitalizations. TRIAL REGISTRATION ClinicalTrials.gov Identifier NCT02105844.
- Published
- 2021
43. Apelin-potential therapy for COVID-19?
- Author
-
Saeedi Saravi, Seyed Soheil and Beer, Jürg H.
- Published
- 2020
- Full Text
- View/download PDF
44. Blood Omega-3 Fatty Acids Are Inversely Associated With Albumin-Creatinine Ratio in Young and Healthy Adults (The Omega-Kid Study)
- Author
-
Filipovic, Mark G., primary, Reiner, Martin F., additional, Rittirsch, Saskia, additional, Irincheeva, Irina, additional, Aeschbacher, Stefanie, additional, Grossmann, Kirsten, additional, Risch, Martin, additional, Risch, Lorenz, additional, Limacher, Andreas, additional, Conen, David, additional, and Beer, Juerg H., additional
- Published
- 2021
- Full Text
- View/download PDF
45. Heart rate and adverse outcomes in patients with prevalent atrial fibrillation
- Author
-
Moschovitis, Giorgio, primary, Johnson, Linda S B, additional, Blum, Steffen, additional, Aeschbacher, Stefanie, additional, De Perna, Maria Luisa, additional, Pagnamenta, Alberto, additional, Mayer Melchiorre, Patrizia Assunta, additional, Benz, Alexander P, additional, Kobza, Richard, additional, Di Valentino, Marcello, additional, Zuern, Christine S, additional, Auricchio, Angelo, additional, Conte, Giulio, additional, Rodondi, Nicolas, additional, Blum, Manuel R, additional, Beer, Juerg H, additional, Kühne, Michael, additional, Osswald, Stefan, additional, and Conen, David, additional
- Published
- 2021
- Full Text
- View/download PDF
46. A factor score reflecting cognitive functioning in patients from the Swiss Atrial Fibrillation Cohort Study (Swiss-AF)
- Author
-
Springer, Anne, Monsch, Andreas U, Dutilh, Gilles, Coslovsky, Michael, Kievit, Rogier A, Bonati, Leo H, Conen, David, Aeschbacher, Stefanie, Beer, Juerg H, Schwenkglenks, Matthias, Fischer, Urs, Meyer-Zuern, Christine S, Conte, Giulio, Moutzouri, Elisavet, Moschovitis, Giorgio, Kühne, Michael, Osswald, Stefan, University of Zurich, and Springer, Anne
- Subjects
1000 Multidisciplinary ,1300 General Biochemistry, Genetics and Molecular Biology ,360 Social problems & social services ,610 Medicine & health ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) ,1100 General Agricultural and Biological Sciences ,11171 Cardiocentro Ticino - Abstract
BACKGROUND Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is considered as risk factor for the development of mild cognitive impairment (MCI) and dementia. However, dynamics of cognitive functions are subtle, and neurocognitive assessments largely differ in detecting these changes. We aimed to develop and evaluate a score which represents the common aspects of the cognitive functions measured by validated tests (i.e., "general cognitive construct"), while reducing overlap between tests and be more sensitive to identify changes in overall cognitive functioning. METHODS We developed the CoCo (cognitive construct) score to reflect the cognitive performance obtained by all items of four neurocognitive assessments (Montreal Cognitive Assessment (MoCA); Trail Making Test; Semantic Fluency, animals; Digital Symbol Substitution Test). The sample comprised 2,415 AF patients from the Swiss Atrial Fibrillation Cohort Study (Swiss-AF), 87% aged at least 65 years. Psychometric statistics were calculated for two cognitive measures based on (i) the full set of items from the neurocognitive test battery administered in the Swiss-AF study (i.e., CoCo item set) and (ii) the items from the widely used MoCA test. For the CoCo item set, a factor score was derived based on a principal component analysis, and its measurement properties were analyzed. RESULTS Both the MoCA item set and the full neurocognitive test battery revealed good psychometric properties, especially the full battery. A one-factor model with good model fit and performance across time and groups was identified and used to generate the CoCo score, reflecting for each patient the common cognitive skill performance measured across the full neurocognitive test battery. The CoCo score showed larger effect sizes compared to the MoCA score in relation to relevant clinical variables. CONCLUSION The derived factor score allows summarizing AF patients' cognitive performance as a single score. Using this score in the Swiss-AF project increases measurement sensitivity and decreases the number of statistical tests needed, which will be helpful in future studies addressing how AF affects the risk of developing cognitive impairment.
- Published
- 2020
- Full Text
- View/download PDF
47. A significant increase in exercise test performance with virtual group motivation: a randomised open-label controlled trial.
- Author
-
Wilzeck, Verena C, Hufschmid, Janik, Bischof, Louis, Hansi, Christopher, Nägele, Matthias P, Beer, Juerg H, Hufschmid, Urs, Wilzeck, Verena C, Hufschmid, Janik, Bischof, Louis, Hansi, Christopher, Nägele, Matthias P, Beer, Juerg H, and Hufschmid, Urs
- Abstract
AIMS Exercise stress testing is frequently used for the assessment of coronary artery disease. As the validity of the test result is highly dependent on the patient’s cooperation and motivation, we hypothesised that virtual group motivation would result in a higher exercise capacity and may increase the test’s validity. METHODS 108 patients at a Swiss teaching hospital with an indication for exercise testing were included in a controlled, open-label trial and randomised 1:1 to treadmill exercise testing whilst either watching a video of a walking group (video group, n = 43), or watching a static image of flowers (image group, n = 43). The video showed a group of five amateur runners, giving the patients the impression of running within the group. As primary outcomes, the performance achieved and the perceived level of comfort during the test were analysed. RESULTS The video group achieved significantly higher percentages of their age-predicted METs (149 ± 32% vs 135 ± 29%, p = 0.041) and longer exercise durations (11:12 ± 2:54 min vs 08:54 ± 02:39 min, p <0.001). Levels of comfort (8.4 ± 1.4 vs 7.5 ± 1.7 analogue scale, p = 0.011) and closeness to their physical limits (8.9 ± 0.8 vs 8.1 ± 1.5, p = 0.005) were rated significantly higher by patients in the video group. CONCLUSIONS Patients watching a video of a running group achieved significantly higher maximum exercise levels and longer test durations. This may have implications for the test’s validity. Furthermore, the virtual setting enhanced patient comfort. (This trial was formally registered at clinicaltrials.gov: trial ID NCT03704493.).
- Published
- 2020
48. A factor score reflecting cognitive functioning in patients from the Swiss Atrial Fibrillation Cohort Study (Swiss-AF)
- Author
-
Springer, Anne; https://orcid.org/0000-0002-4829-1041, Monsch, Andreas U, Dutilh, Gilles, Coslovsky, Michael, Kievit, Rogier A; https://orcid.org/0000-0003-0700-4568, Bonati, Leo H, Conen, David, Aeschbacher, Stefanie, Beer, Juerg H, Schwenkglenks, Matthias; https://orcid.org/0000-0001-7217-1173, Fischer, Urs, Meyer-Zuern, Christine S, Conte, Giulio, Moutzouri, Elisavet, Moschovitis, Giorgio, Kühne, Michael, Osswald, Stefan; https://orcid.org/0000-0002-9240-6731, Springer, Anne; https://orcid.org/0000-0002-4829-1041, Monsch, Andreas U, Dutilh, Gilles, Coslovsky, Michael, Kievit, Rogier A; https://orcid.org/0000-0003-0700-4568, Bonati, Leo H, Conen, David, Aeschbacher, Stefanie, Beer, Juerg H, Schwenkglenks, Matthias; https://orcid.org/0000-0001-7217-1173, Fischer, Urs, Meyer-Zuern, Christine S, Conte, Giulio, Moutzouri, Elisavet, Moschovitis, Giorgio, Kühne, Michael, and Osswald, Stefan; https://orcid.org/0000-0002-9240-6731
- Abstract
BACKGROUND Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is considered as risk factor for the development of mild cognitive impairment (MCI) and dementia. However, dynamics of cognitive functions are subtle, and neurocognitive assessments largely differ in detecting these changes. We aimed to develop and evaluate a score which represents the common aspects of the cognitive functions measured by validated tests (i.e., "general cognitive construct"), while reducing overlap between tests and be more sensitive to identify changes in overall cognitive functioning. METHODS We developed the CoCo (cognitive construct) score to reflect the cognitive performance obtained by all items of four neurocognitive assessments (Montreal Cognitive Assessment (MoCA); Trail Making Test; Semantic Fluency, animals; Digital Symbol Substitution Test). The sample comprised 2,415 AF patients from the Swiss Atrial Fibrillation Cohort Study (Swiss-AF), 87% aged at least 65 years. Psychometric statistics were calculated for two cognitive measures based on (i) the full set of items from the neurocognitive test battery administered in the Swiss-AF study (i.e., CoCo item set) and (ii) the items from the widely used MoCA test. For the CoCo item set, a factor score was derived based on a principal component analysis, and its measurement properties were analyzed. RESULTS Both the MoCA item set and the full neurocognitive test battery revealed good psychometric properties, especially the full battery. A one-factor model with good model fit and performance across time and groups was identified and used to generate the CoCo score, reflecting for each patient the common cognitive skill performance measured across the full neurocognitive test battery. The CoCo score showed larger effect sizes compared to the MoCA score in relation to relevant clinical variables. CONCLUSION The derived factor score allows summarizing AF patients' cognitive performance as a single score. Using this s
- Published
- 2020
49. Elevated HbA1c is not associated with recurrent venous thromboembolism in the elderly, but with all-cause mortality- the SWEETCO 65+ study
- Author
-
Mathis, Alexandra, Villiger, Lukas, Reiner, Martin F, Egloff, Michael, Schmid, Hans Ruedi, Stivala, Simona; https://orcid.org/0000-0003-1549-8932, Limacher, Andreas, Mean, Marie, Aujesky, Drahomir, Rodondi, Nicolas, Angelillo-Scherrer, Anna, Righini, Marc, Staub, Daniel, Aschwanden, Markus, Frauchiger, Beat, Osterwalder, Joseph, Kucher, Nils, Matter, Christian M, Banyai, Martin, Hugli, Oliver; https://orcid.org/0000-0003-2312-1625, Beer, Juerg H, Mathis, Alexandra, Villiger, Lukas, Reiner, Martin F, Egloff, Michael, Schmid, Hans Ruedi, Stivala, Simona; https://orcid.org/0000-0003-1549-8932, Limacher, Andreas, Mean, Marie, Aujesky, Drahomir, Rodondi, Nicolas, Angelillo-Scherrer, Anna, Righini, Marc, Staub, Daniel, Aschwanden, Markus, Frauchiger, Beat, Osterwalder, Joseph, Kucher, Nils, Matter, Christian M, Banyai, Martin, Hugli, Oliver; https://orcid.org/0000-0003-2312-1625, and Beer, Juerg H
- Abstract
The association of glycated hemoglobin (HbA1c) with venous thromboembolism (VTE) and death in the elderly is unknown. In the SWEETCO 65+ study we analyzed prospectively a Swiss Cohort of Elderly Patients with Venous Thromboembolism (SWITCO 65+). 888 patients were enrolled for the SWEETCO 65+ analysis. HbA1c was determined at baseline and divided into three categories (HbA1c < 5.7%, normal range; 5.7-6.49%, pre-diabetic range; and >6.5%, diabetic range). Median follow-up was 2.5 years. The primary endpoint was recurrent VTE. Secondary endpoints included all-cause mortality and major bleeds. The total prevalence of diabetes was 22.1%. The risk of recurrent VTE was similar in patients with HbA1c with pre-diabetes (adjusted subhazard ratio (aSHR) 1.07 [0.70 to 1.63]) and diabetes (aSHR 0.73 [0.39 to 1.37]) as compared to those with a HbA1c in the normal range. However, a HbA1c ≥ 6.5% (median IQ range 7.0 [6.70;7.60]) was significantly associated with a higher risk of all-cause mortality (adjusted hazard ratio [aHR] 1.83 [1.21 to 2.75]). In summary we found no association between HbA1c and major bleeding. Elevated HbA1c levels are not associated with recurrent VTE but with increased all-cause mortality in an elderly population with acute VTE.
- Published
- 2020
50. Towards personalized antithrombotic management with drugs and devices across the cardiovascular spectrum.
- Author
-
Lüscher, Thomas F, Davies, Allan, Beer, Juerg H, Valgimigli, Marco, Nienaber, Christoph A, Camm, John A, Baumgartner, Iris, Diener, Hans-Christoph, and Konstantinides, Stavros V
- Subjects
BLOOD coagulation disorders ,THROMBOSIS ,ATRIAL fibrillation ,VITAMIN K ,PLATELET aggregation inhibitors - Abstract
Intravascular thrombus formation and embolization are among the most frequent events leading to a number of cardiovascular conditions with high morbidity and mortality. The underlying causes are stasis of the circulating blood, genetic and acquired coagulation disorders, and reduced antithrombotic or prothrombotic properties of the vascular wall (Virchow's triad). In the venous system, intravascular thrombi can cause venous thrombosis and pulmonary and even peripheral embolism including ischaemic stroke [through a patent foramen ovale (PFO)]. Thrombi in the left atrium and its appendage or ventricle form in the context of atrial fibrillation and infarction, respectively. Furthermore, thrombi can form on native or prosthetic aortic valves, within the aorta (in particular at sites of ulcers, aortic dissection, and abdominal aneurysms), and in cerebral and peripheral arteries causing stroke and critical limb ischaemia, respectively. Finally, thrombotic occlusion may occur in arteries supplying vital organs such the heart, brain, kidney, and extremities. Thrombus formation and embolization can be managed with anticoagulants and devices depending on where they form and embolize and on patient characteristics. Vitamin K antagonists are preferred in patients with mechanical valves, while novel oral anticoagulants are first choice in most other cardiovascular conditions, in particular venous thromboembolism and atrial fibrillation. As anticoagulants are associated with a risk of bleeding, devices such as occluders of a PFO or the left atrial appendage are preferred in patients with an increased bleeding risk. Platelet inhibitors such as aspirin and/or P2Y
12 antagonists are preferred in the secondary prevention of coronary artery disease, stroke, and peripheral artery disease either alone or in combination depending on the clinical condition. A differential and personalized use of anticoagulants, platelet inhibitors, and devices is recommended and reviewed in this article. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.