116 results on '"Addison S"'
Search Results
2. Isolated left bundle branch block progressing to complete heart block and asystole: A novel presentation of a desmin mutation
- Author
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Gearhart, Addison S and Batra, Anjan S
- Subjects
Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Complete heart block ,Desminopathy ,Left bundle branch block ,Pacemaker ,Syncope - Published
- 2018
3. Laparoscopic cholecystectomy performed by a surgical care practitioner: a review of outcomes
- Author
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Odogwu, S, primary, Morris, S, additional, Addison, S, additional, and Abbott, S, additional
- Published
- 2024
- Full Text
- View/download PDF
4. Early Initiation of Ceftaroline-Based Combination Therapy for Methicillin-resistant Staphylococcus aureus Bacteremia
- Author
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Hicks, Addison S., primary, Dolan, Mackenzie A., additional, Shah, Megan D., additional, Elwood, Sarah E., additional, Platts-Mills, James A., additional, Madden, Gregory R., additional, Elliott, Zachary S., additional, and Eby, Joshua C., additional
- Published
- 2024
- Full Text
- View/download PDF
5. Amine Basicity of Quinoline ATP Synthase Inhibitors Drives Antibacterial Activity against Pseudomonas aeruginosa
- Author
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Ward, Katie T., primary, Williams, Alexander P. L., additional, Blair, Courtney A., additional, Chatterjee, Ananya M., additional, Karthikeyan, Abirami, additional, Roper, Addison S., additional, Kellogg, Casey N., additional, Steed, P. Ryan, additional, and Wolfe, Amanda L., additional
- Published
- 2023
- Full Text
- View/download PDF
6. Multi-faith Chaplaincy’s Outcomes-Based Measures: The Tail that Wags the Dog
- Author
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Tenorio, Addison S, primary
- Published
- 2023
- Full Text
- View/download PDF
7. The Value of Outpatient Parenteral Antimicrobial Therapy: Better Care in 27 Minutes.
- Author
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Hicks, Addison S and Eby, Joshua C
- Subjects
- *
COMMUNICABLE diseases , *OUTPATIENT services in hospitals , *INTRAVENOUS therapy , *ANTI-infective agents , *TIME - Abstract
The authors discuss a study by A. J. Schranz and colleagues, published in the issue, which aimed to quantify uncompensated time that infectious diseases (ID) providers and staff spend delivering outpatient parenteral antimicrobial therapy (OPAT) care to provide a benchmark for discussions regarding renumeration. Topics include how the researchers facilitated comparison across variable OPAT course lengths and options for OPAT compensation supported by Schranz et al.
- Published
- 2024
- Full Text
- View/download PDF
8. Multi-faith Chaplaincy's Outcomes-Based Measures: The Tail that Wags the Dog.
- Author
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Tenorio, Addison S
- Subjects
- *
DOGS , *CHAPLAINS , *PASTORAL care , *THEOLOGY , *PATIENT autonomy , *MEDICAL care - Abstract
The current manner of practicing chaplaincy in health care is one which prizes the multi-faith chaplain. When one asks multi-faith chaplain, "To whom are you beholden?" they will respond, "The patient." This is evident in the way that chaplaincy is currently practiced and taught, which prizes the use of psychology over recourse to theology. Chaplaincy's recourse to practices whose aims are directed toward the efficient rather than the eternal challenges its original telos. This paper looks at this question by blending a Catholic and Engelhardtian approach to conclude that chaplains should recognize that they are beholden to God, rather than to patients' autonomy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
9. Defining Disability: Creating a Monster?
- Author
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Marissa D Espinoza and Addison S Tenorio
- Subjects
Philosophy ,Issues, ethics and legal aspects ,General Medicine - Abstract
Disability is often defined as deviation from putative norms of physical, cognitive, or affective function. This definition is normatively laden, causing people with disabilities to be thought of as “different” and treated with pity. We address the predominant theme of this issue on “Disability Identity”: defining and imposing the category of “disability” and attempting to overcome it through medical intervention. The issue culminates in a call for courageous humility as the proper response to encounters with disability, providing medical professionals with the disposition to resist medicine’s inherent drive to fix what is perceived to be broken—that which strays from the norm. We hope that this issue might act as a clarion call to medical professionals to reevaluate how they see and interact with “disability” as a category, and ultimately with people with disabilities, especially with respect to what may be owed to persons with disabilities from society.
- Published
- 2022
10. Advancing Human-Robot Teams: A Framework for Understanding Swift Trust
- Author
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Sabina M. Patel, Sarah E. Napoli, Addison S. Rohrbacher, Elizabeth H. Lazzara, and Elizabeth Phillips
- Subjects
Medical Terminology ,Medical Assisting and Transcription - Abstract
In this paper, we describe how swift trust in human-robot (HR) teams is developed through the incorporation of surface-level cues and imported information. Surface-level cues are physical characteristics whereas imported information serves to shape preconceived notions about the robot itself. A multidimensional continuum is used to explore the effects of varying surface-level cues and imported information on the type of swift trust that may form as a result: high, medium, and low swift trust. Similar surface cues and positive information suggest higher swift trust development, whereas, negative imported information and differing surface cues evoke low swift trust. Surface cues and imported information that are incongruous leads to medium swift trust formation. This paper offers insights into the development of swift trust depending on the specific traits relevant to both the human and robot team members.
- Published
- 2022
11. Amine Basicity of Quinoline ATP Synthase Inhibitors Drives Antibacterial Activity against Pseudomonas aeruginosa.
- Author
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Ward, Katie T., Williams, Alexander P. L., Blair, Courtney A., Chatterjee, Ananya M., Karthikeyan, Abirami, Roper, Addison S., Kellogg, Casey N., Steed, P. Ryan, and Wolfe, Amanda L.
- Published
- 2024
- Full Text
- View/download PDF
12. Adolescent Attitudes Toward Sexually Transmitted Infection Screening in the Emergency Department
- Author
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Gearhart, Addison S., Badolato, Gia M., and Goyal, Monika K.
- Published
- 2020
- Full Text
- View/download PDF
13. Experience of General Surgery Residents in the Creation of Small Bowel and Colon Anastomoses
- Author
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Nemeth, Zoltan H., Lazar, Eric L., Paglinco, Samantha R., Hicks, Addison S., Lei, Jason, Barratt-Stopper, Patricia A., and Rolandelli, Rolando H.
- Published
- 2016
- Full Text
- View/download PDF
14. Diagnostic accuracy and limitations of post-mortem MRI for neurological abnormalities in fetuses and children
- Author
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Arthurs, O.J., Thayyil, S., Pauliah, S.S., Jacques, T.S., Chong, W.K., Gunny, R., Saunders, D., Addison, S., Lally, P., Cady, E., Jones, R., Norman, W., Scott, R., Robertson, N.J., Wade, A., Chitty, L., Taylor, A.M., and Sebire, N.J.
- Published
- 2015
- Full Text
- View/download PDF
15. Defining Disability: Creating a Monster?
- Author
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Espinoza, Marissa D, primary and Tenorio, Addison S, additional
- Published
- 2022
- Full Text
- View/download PDF
16. Advancing Human-Robot Teams: A Framework for Understanding Swift Trust
- Author
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Patel, Sabina M., primary, Napoli, Sarah E., additional, Rohrbacher, Addison S., additional, Lazzara, Elizabeth H., additional, and Phillips, Elizabeth, additional
- Published
- 2022
- Full Text
- View/download PDF
17. Effect of Dynamic Culture and Periodic Compression on Human Mesenchymal Stem Cell Proliferation and Chondrogenesis
- Author
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Guo, Ting, Yu, Li, Lim, Casey G., Goodley, Addison S., Xiao, Xuan, Placone, Jesse K., Ferlin, Kimberly M., Nguyen, Bao-Ngoc B., Hsieh, Adam H., and Fisher, John P.
- Published
- 2016
- Full Text
- View/download PDF
18. Direct Anterior Approach: Risk Factor for Early Femoral Failure of Cementless Total Hip Arthroplasty: A Multicenter Study
- Author
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Meneghini, R. Michael, Elston, Addison S., Chen, Antonia F., Kheir, Michael M., Fehring, Thomas K., and Springer, Bryan D.
- Published
- 2017
- Full Text
- View/download PDF
19. On Performing Reinfibulation in Catholic Hospitals
- Author
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Addison S. Tenorio
- Subjects
General Medicine - Abstract
Female genital mutilation/cutting is a multifaceted, culturally entrenched issue. In response to the United States Conference of Catholic Bishops’ resources dealing with the issue of FGM/C, this paper explores what resources sexual ethics can provide Catholic hospitals facing this issue, specifically with regards to the request for reinfibulation (the restoration of infibulation, also called FGM Type III). FGM/C ought not to be treated as a univocal medical practice; rather, in natural law evaluations of the act, the practice of reinfibulation ought to be separately acknowledged. Reinfibulation cannot be properly considered a mutilation in the same way that other types of FGM/C are. Thus reinfibulation should be performed in Catholic hospitals for those women who request it, as part of delivering culturally competent care, justifiable through the principle of material cooperation.
- Published
- 2020
20. The Next Frontier in Pediatric Cardiology: Artificial Intelligence
- Author
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Sharib, Gaffar, Addison S, Gearhart, and Anthony C, Chang
- Subjects
Artificial Intelligence ,Cardiology ,Electronic Health Records ,Humans ,Precision Medicine ,Child ,Algorithms - Abstract
Artificial intelligence (AI) in the last decade centered primarily around digitizing and incorporating the large volumes of patient data from electronic health records. AI is now poised to make the next step in health care integration, with precision medicine, imaging support, and development of individual health trends with the popularization of wearable devices. Future clinical pediatric cardiologists will use AI as an adjunct in delivering optimum patient care, with the help of accurate predictive risk calculators, continual health monitoring from wearables, and precision medicine. Physicians must also protect their patients' health information from monetization or exploitation.
- Published
- 2020
21. Outcome and Cost Analysis of Hand-Sewn and Stapled Anastomoses in the Reversal of Loop Ileostomy
- Author
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Patricia B. Stopper, Addison S. Hicks, Rohan Sawhney, Samantha R. Paglinco, Zoltan H. Nemeth, Dorian A. Bogdanovski, Stefanie A. Pilip, and Rolando H. Rolandelli
- Subjects
Stapled anastomosis ,medicine.medical_specialty ,Total cost ,business.industry ,medicine.medical_treatment ,Loop ileostomy ,General Medicine ,Common procedures ,Anastomosis ,Surgery ,03 medical and health sciences ,Ileostomy ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine ,Cost analysis ,030211 gastroenterology & hepatology ,business ,Hand sewn - Abstract
Diverting loop ileostomies are common procedures for protecting high-risk anastomoses. There is little consensus on the most ideal technique both in terms of cost efficiency and outcome. Data for this study were collected from 101 patients who underwent loop ileostomy reversal between 2009 and 2014 at Morristown Medical Center. Of the 101 patients included in the review, 57 received a hand-sewn anastomosis (HS-A) and 44 received a stapled anastomosis (S-A). Average total hospital charges for stapled anastomoses were significantly greater than that for hand-sewn anastomoses, as were total operating room supply costs. When the total cost of the operation itself was considered, S-A cases were still found to be significantly greater than HS-A cases. Hospital room charges, total lab charges, pathology charges, and EKG/ECG charges were all greater for S-A cases than HS-A cases. Overall costs were greater for S-As than hand-sewn anastomoses and because of a lack of difference in procedure length, stapler supply costs were not offset. Complication rates and length of stay were also similar between the techniques. We found S-A cases to be more costly and have a greater cost/hour than HS-A cases.
- Published
- 2018
22. The Next Frontier in Pediatric Cardiology
- Author
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Gaffar, Sharib, primary, Gearhart, Addison S., additional, and Chang, Anthony C., additional
- Published
- 2020
- Full Text
- View/download PDF
23. Isolated left bundle branch block progressing to complete heart block and asystole: A novel presentation of a desmin mutation
- Author
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Anjan S. Batra and Addison S. Gearhart
- Subjects
medicine.medical_specialty ,biology ,business.industry ,Left bundle branch block ,Heart block ,Syncope (genus) ,030204 cardiovascular system & hematology ,biology.organism_classification ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Mutation (genetic algorithm) ,medicine ,Cardiology ,Desmin ,Presentation (obstetrics) ,Asystole ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Published
- 2018
24. Phytophthora aleatoria sp. nov., associated with root and collar damage on Pinus radiata from nurseries and plantations
- Author
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Scott, P., Taylor, P., Gardner, J., Puértolas, A., Panda, P., Addison, S., Hood, I., Burgess, T., Horner, I., Williams, N., McDougal, R., Scott, P., Taylor, P., Gardner, J., Puértolas, A., Panda, P., Addison, S., Hood, I., Burgess, T., Horner, I., Williams, N., and McDougal, R.
- Abstract
During routine surveys of Pinus radiata plantations in the Nelson region, New Zealand, a Phytophthora species was isolated in association with bleeding stem cankers and rhizosphere soil. This isolate grew more slowly than other Phytophthora species associated with P. radiata in New Zealand, and was morphologically similar to isolates of Phytophthora cactorum previously associated with horticulture production, and isolates that were morphologically identified as P. cactorum from P. radiata in Nelson since the 1970s. Phylogenetic analyses of the ITS, cox1, and ß-tubulin _F1A and ß-tubulin_F2A regions confirmed this to be a new species closely related to P. hedraiandra in Clade 1. The new species is described here as Phytophthora aleatoria sp. nov. It produces partially caducous, papillate, ovoid to rarely globose or limoniform sporangia, markedly aplerotic oogonia forming thin-walled oospores, and paragynous (mainly) or amphigynous antheridia on some cultures. To date, this species has been confirmed on P. radiata in New Zealand across a range of sites within the North Canterbury, Nelson, Hawkes Bay, Taupo and the Bay of Plenty regions.
- Published
- 2019
25. Experience of General Surgery Residents in the Creation of Small Bowel and Colon Anastomoses
- Author
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Addison S. Hicks, Patricia Barratt-Stopper, Eric L. Lazar, Samantha R. Paglinco, Rolando H. Rolandelli, Zoltan H. Nemeth, and Jason Lei
- Subjects
medicine.medical_specialty ,Colectomies ,medicine.medical_treatment ,030230 surgery ,Anastomosis ,Education ,Colonic Diseases ,03 medical and health sciences ,0302 clinical medicine ,Anastomotic leaks ,Intestine, Small ,Surgical Stapling ,medicine ,Humans ,Laparoscopy ,Small bowel resection ,medicine.diagnostic_test ,Adult patients ,Proctocolectomy ,business.industry ,General surgery ,Anastomosis, Surgical ,Suture Techniques ,Internship and Residency ,Residency program ,Surgery ,Education, Medical, Graduate ,General Surgery ,030220 oncology & carcinogenesis ,Clinical Competence ,business - Abstract
Background With the introduction of stapling devices (SDs), the proportion of hand-sewn (HS) intestinal anastomoses (IAs) has declined. As more IAs are constructed with SDs, there are fewer opportunities for general surgery residents (GSRs) to acquire the skills for HS techniques during their training. Study Design Data for this study were extracted from an existing database of all IAs performed at the Department of Surgery of the Morristown Medical Center since 2003. For the purposes of this study, a 5.5-year timeframe was used between July 2006 and 2011, which contained 1659 IA operations on adult patients with resident involvement. GSRs of the 5-year general surgery residency program were grouped by postgraduate year (PGY) for further analysis. Results The number of all IAs created by each resident during the 5-year training was 67.2 on average. Most of these operations were done in the last 2 years of the training: 45.1% of all IAs in PGY5 and 37.3% of all IAs in PGY4. Of all, 1659 IAs performed in the study period, 711 (42.9% of total) were done laparoscopically and 948 (57.1% of all IAs) were done as open operations. Laparoscopic operations had a proportionally higher rate of SD use when compared to open cases (90.9% vs 82.4%). On average, each resident constructed 9.4 HS IAs (13.98% of all IAs) and 57.8 SD IAs (86.02% of total). Out of all anastomoses, ostomy reversals (30.7%) had the highest percentage of HS suturing followed by right colectomies (27.5%), ileal pouch-anal anastomoses and total colectomies and proctocolectomies (23.3%), small bowel resection (17.0%), and left colectomies (5.5%). Regardless of the location of the operation, stapled and sutured anastomoses had similar outcomes measured by the rate of anastomotic leaks. Residents used significantly more SDs in the creation of anastomoses than HS suturing in the PGY3, PGY4, and PGY5 years. We also documented that attending surgeons who are older more often used HS suturing than their younger colleagues when creating IAs. Conclusions The experiences of GSRs in IA operations are heavily weighted toward the use of SDs. There are select cases, however, when HS suturing can have an advantage over stapler use in anastomosis creation. Therefore, we believe that GSRs should continue learning, perfecting, and using the both techniques.
- Published
- 2016
26. Ultrasonic Structural Health Monitoring to Assess the Integrity of Spinal Growing Rods In Vitro
- Author
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Matthew E. Oetgen, Darryll J. Pines, Adam H. Hsieh, Addison S. Goodley, and Byungseok Yoo
- Subjects
genetic structures ,Health Status ,Thoracic Vertebrae ,Rod ,03 medical and health sciences ,0302 clinical medicine ,Lamb waves ,Pedicle Screws ,Materials Testing ,Humans ,Medicine ,Waveform ,Ultrasonics ,Orthopedics and Sports Medicine ,Titanium ,030222 orthopedics ,Lumbar Vertebrae ,business.industry ,Biomechanical Phenomena ,Spinal Fusion ,Amplitude ,Transducer ,Scoliosis ,Fracture (geology) ,Ultrasonic sensor ,sense organs ,Structural health monitoring ,business ,030217 neurology & neurosurgery ,Biomedical engineering - Abstract
Background Rod fracture is a common complication of growing rods and can result in loss of correction, patient discomfort, and unplanned revision surgery. The ability to quantitate rod integrity at each lengthening would be advantageous to avoid this complication. We investigate the feasibility of applying structural health monitoring to evaluate the integrity of growing rods in vitro. Methods Single-rod titanium 4.5-mm growing rod constructs (n = 9), one screw proximally and one distally connected by in-line connectors, were assembled with pedicle screws fixed in polyethylene blocks. Proximal and distal ends were loaded and constructs subjected to cyclic axial compression (0–100 N at 1 Hz), with incrementally increasing maximum compressive loads of 10 N every 9k cycles until failure. Four piezoceramic transducers (PZTs) were mounted along the length the constructs to interrogate the integrity of the rods with an ultrasonic, guided lamb wave approach. Every 9k cycles, an 80 V excitatory voltage was applied to a PZT to generate high-frequency vibrations, which, after propagating through the construct, was detected by the remaining PZTs. Amplitude differences between pre- and postload waveform signals were calculated until rod failure. Results Average construct lifetime was 88,991 ± 13,398 cycles. All constructs failed due to rod fracture within 21 mm (mean = 15 ± 4.5 mm) of a screw or connector. Amplitude differences between pre- and postload increased in a stepwise fashion as constructs were cycled. Compared to baseline, we found a 1.8 ± 0.6-fold increase in amplitude 18k cycles before failure, a 2.2 ± 1.0-fold increase in amplitude 9k cycles before failure, and a 2.75 ± 1.5-fold increase in amplitude immediately before rod fracture. Conclusion We describe a potential method for assessing the structural integrity of growing rods using ultrasonic structural health monitoring. These preliminary data demonstrate the ability of periodic rod assessment to detect structural changes in cycled growing rods, which appear to correspond to subclinical rod fatigue before rod fracture.
- Published
- 2016
27. CO2 Dry Cleaning: A Benign Solvent Demonstration Accessible to K–8 Audiences
- Author
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Lindsay K. Gallo, Henry M. Ackerman, Addison S. Gwinner, Kristin N. Esdale, Alexandra Bishop, Jeffrey L. Katz, Anna Krauss, John D. Sears, and Reuben Hudson
- Subjects
010405 organic chemistry ,Chemistry ,business.industry ,05 social sciences ,050301 education ,Nanotechnology ,General Chemistry ,Dry cleaning ,01 natural sciences ,0104 chemical sciences ,Education ,Solvent ,Process engineering ,business ,0503 education - Abstract
A quick demonstration is described to showcase the use of CO2 as an alternative, benign dry cleaning solvent. The demonstration includes visible evidence of CO2 as a solid, a liquid, and a gas, making it ideal as part of a broader lesson on states of matter. The demonstration relies on a technique for generating liquid CO2 in a centrifuge tube, which has been used for extractions in undergraduate teaching laboratories for over a decade. This report represents a unique attempt to transfer this method to the K–8 curriculum.
- Published
- 2016
28. Outcome and Cost Analysis of Hand-Sewn and Stapled Anastomoses in the Reversal of Loop Ileostomy
- Author
-
Zoltan H, Nemeth, Dorian A, Bogdanovski, Addison S, Hicks, Samantha R, Paglinco, Rohan, Sawhney, Stefanie A, Pilip, Patricia B, Stopper, and Rolando H, Rolandelli
- Subjects
Adult ,Male ,Reoperation ,New Jersey ,Ileostomy ,Anastomosis, Surgical ,Suture Techniques ,Middle Aged ,Hospital Charges ,Surgical Stapling ,Humans ,Female ,Hospital Costs ,Retrospective Studies - Abstract
Diverting loop ileostomies are common procedures for protecting high-risk anastomoses. There is little consensus on the most ideal technique both in terms of cost efficiency and outcome. Data for this study were collected from 101 patients who underwent loop ileostomy reversal between 2009 and 2014 at Morristown Medical Center. Of the 101 patients included in the review, 57 received a hand-sewn anastomosis (HS-A) and 44 received a stapled anastomosis (S-A). Average total hospital charges for stapled anastomoses were significantly greater than that for hand-sewn anastomoses, as were total operating room supply costs. When the total cost of the operation itself was considered, S-A cases were still found to be significantly greater than HS-A cases. Hospital room charges, total lab charges, pathology charges, and EKG/ECG charges were all greater for S-A cases than HS-A cases. Overall costs were greater for S-As than hand-sewn anastomoses and because of a lack of difference in procedure length, stapler supply costs were not offset. Complication rates and length of stay were also similar between the techniques. We found S-A cases to be more costly and have a greater cost/hour than HS-A cases.
- Published
- 2018
29. The feasibility of telemedicine in pediatric cardiology
- Author
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Justin M Pick, Brian K Lee, Rachel Watson, Anjan S. Batra, Addison S. Gearhart, and Ian Lee
- Subjects
Telemedicine ,Pediatric endocrinology ,business.industry ,Pediatric critical care medicine ,medicine.disease ,Pediatric sports medicine ,Pediatric emergency medicine ,Pediatric Infectious Disease ,medicine ,book.journal ,Medical emergency ,Pediatric dermatology ,business ,book ,Pediatric cardiology - Published
- 2018
30. Adolescent Attitudes Toward Sexually Transmitted Infection Screening in the Emergency Department
- Author
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Addison S. Gearhart, Monika K. Goyal, and Gia M. Badolato
- Subjects
Male ,Infection screening ,medicine.medical_specialty ,Adolescent ,Cross-sectional study ,Sexually Transmitted Diseases ,urologic and male genital diseases ,Logistic regression ,Asymptomatic ,Article ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Humans ,Mass Screening ,Medicine ,030212 general & internal medicine ,Young adult ,business.industry ,virus diseases ,General Medicine ,Emergency department ,Odds ratio ,female genital diseases and pregnancy complications ,Confidence interval ,Cross-Sectional Studies ,Family medicine ,Pediatrics, Perinatology and Child Health ,Emergency Medicine ,Female ,medicine.symptom ,Emergency Service, Hospital ,business ,Attitude to Health - Abstract
Objectives Adolescents who seek care in emergency departments (EDs) are often at high risk for sexually transmitted infections (STIs). The objective of this study was to assess adolescent attitudes toward ED-based STI screening. Methods We conducted a secondary analysis of a cross-sectional study that evaluated STI screening acceptability and prevalence when STI testing was universally offered to asymptomatic adolescents presenting to the ED for care. Adolescents 14 to 21 years old completed a computerized survey and answered questions regarding attitudes toward ED-based STI screening and sexual behavior. We performed multivariable logistic regression to compare differences in attitudes toward ED-based STI screening among patients who agreed versus declined STI testing. Results Of 553 adolescents, 326 (59.0%) agreed to be tested for STIs. Most (72.1%) believed the ED was an appropriate place for STI screening. Patients who agreed to be tested for STIs were more likely to positively endorse ED-based STI screening than those who declined STI testing [77.0% vs 64.8%; adjusted odds ratios, 1.6; 95% confidence interval (CI), 1.1-2.4]. Most (82.6%) patients stated they would feel comfortable getting tested for STIs in the ED. There was no difference in the comfort level of ED-based STI testing between those who agreed and declined STI testing (83.5% vs 81.4%; adjusted odds ratios, 1.1; 95% CI, 0.7-1.8). Conclusion Our results suggest that adolescents view the ED as an acceptable location for STI screening. Therefore, the ED may serve a role in increasing the accessibility of STI detection and prevention resources for adolescents.
- Published
- 2018
31. Estrogen‐Related Receptor Gamma Gene Therapy Promotes Therapeutic Angiogenesis and Muscle Recovery in Preclinical Model of PAD
- Author
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Danesh H. Sopariwala, Andrea S. Rios, Addison Saley, Ashok Kumar, and Vihang A. Narkar
- Subjects
angiogenesis ,estrogen‐related receptor gamma ,gene therapy ,limb ischemia ,muscle recovery ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Peripheral arterial disease and critical limb ischemia are cardiovascular complications associated with vascular insufficiency, oxidative metabolic dysfunction, and myopathy in the limbs. Estrogen‐related receptor gamma (ERRγ) has emerged as a dual regulator of paracrine angiogenesis and oxidative metabolism through transgenic mouse studies. Here our objective was to investigate whether postischemic intramuscular targeting of ERRγ via gene therapy promotes ischemic recovery in a preclinical model of peripheral arterial disease/critical limb ischemia. Methods and Results Adeno‐associated virus 9 (AAV9) Esrrg gene delivery vector was developed and first tested via intramuscular injection in murine skeletal muscle. AAV9‐Esrrg robustly increased ERRγ protein expression, induced angiogenic and oxidative genes, and boosted capillary density and succinate dehydrogenase oxidative metabolic activity in skeletal muscles of C57Bl/6J mice. Next, hindlimb ischemia was induced via unilateral femoral vessel ligation in mice, followed by intramuscular AAV9‐Esrrg (or AAV9‐green fluorescent protein) gene delivery 24 hours after injury. ERRγ overexpression increased ischemic neoangiogenesis and markers of endothelial activation, and significantly improved ischemic revascularization measured using laser Doppler flowmetry. Moreover, ERRγ overexpression restored succinate dehydrogenase oxidative metabolic capacity in ischemic muscle, which correlated with increased mitochondrial respiratory complex protein expression. Most importantly, myofiber size to number quantification revealed that AAV9‐Esrrg restores myofibrillar size and mitigates ischemia‐induced myopathy. Conclusions These results demonstrate that intramuscular AAV9‐Esrrg delivery rescues ischemic pathology after hindlimb ischemia, underscoring that Esrrg gene therapy or pharmacological activation could be a promising strategy for the management of peripheral arterial disease/critical limb ischemia.
- Published
- 2023
- Full Text
- View/download PDF
32. A SMART decade: outcomes of an integrated, inclusive, first-year college-level STEM curricular innovation
- Author
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Shannon Jones, Alexis Blake, Lesly Corado-Santiago, Jasmine Crenshaw, Emma Goldman, Fernando Gomez, Chelsea Hall, Harry Hoke, Stephen Holmes, Benjamin Kornegay, Priscilla Kwarteng, Barry Lawson, Meghan Leber, Georges Leconte, Erica Modeste, Kristine Nolin, Michael Norris, Jose Santinni Roma, Addison Swackhammer, Marcella Torres, Joanna Wares, Dominique Ebony Williams, April Hill, Kathy Hoke, Carol Parish, and B. Daniel Pierce
- Subjects
course-based undergraduate research experience (CURE) ,SALG ,curricular innovation ,HHMI ,science technology engineering mathematics (STEM) ,minoritized students ,Education (General) ,L7-991 - Abstract
In the early 2000s, our primarily undergraduate, white institution (PUI/PWI), began recruiting and enrolling higher numbers of students of color and first-generation college students. However, like many of our peer institutions, our established pedagogies and mindsets did not provide these students an educational experience to enable them to persist and thrive in STEM. Realizing the need to systematically address our lack of inclusivity in science majors, in 2012 faculty from multiple disciplines developed the Science, Math, and Research Training (SMART) program. Here, we describe an educational innovation, originally funded by a grant from the Howard Hughes Medical Institute, designed to support and retain students of color, first generation college students, and other students with marginalized identities in the sciences through a cohort-based, integrated, and inclusive first-year experience focused on community and sense of belonging. The SMART program engages first-year students with semester-long themed courses around “real world” problems of antibiotic resistance and viral infections while integrating the fields of Biology, Chemistry, Mathematics, and an optional Computer Science component. In the decade since its inception, 97% of SMART students have graduated or are on track to graduate, with 80.9% of these students earning a major in a STEM discipline. Here, we present additional student outcomes since the initiation of this program, results of the student self-evaluative surveys SALG and CURE, and lessons we have learned from a decade of this educational experience.
- Published
- 2023
- Full Text
- View/download PDF
33. Direct Anterior Approach: Risk Factor for Early Femoral Failure of Cementless Total Hip Arthroplasty: A Multicenter Study
- Author
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Thomas K. Fehring, Addison S. Elston, Bryan D. Springer, Antonia F. Chen, R. Michael Meneghini, and Michael M. Kheir
- Subjects
Male ,Reoperation ,medicine.medical_specialty ,medicine.medical_treatment ,Arthroplasty, Replacement, Hip ,03 medical and health sciences ,Fractures, Bone ,0302 clinical medicine ,Postoperative Complications ,Risk Factors ,Medicine ,Humans ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Risk factor ,Retrospective Studies ,030222 orthopedics ,business.industry ,Bone Cements ,Retrospective cohort study ,Acetabulum ,General Medicine ,Evidence-based medicine ,Middle Aged ,Arthroplasty ,Surgery ,Prosthesis Failure ,Etiology ,Female ,Anterior approach ,Hip Prosthesis ,Periprosthetic Fractures ,business ,Body mass index ,Femoral Fractures ,Total hip arthroplasty - Abstract
Background The direct anterior approach for total hip arthroplasty (THA) is marketed with claims of superiority over other approaches. Femoral exposure can be technically challenging and potentially lead to early failure. We examined whether surgical approach is associated with early THA failure. Methods A retrospective review of 478 consecutive early revision THAs performed within 5 years after the primary THAs at 3 academic centers from 2011 through 2014 was carried out. Exclusion criteria resulted in a final analysis sample of 342 early-failure THAs. The surgical approach of the primary operation that was revised, the time to the revision, and the etiology of the failure leading to the revision were documented. Results Analysis of the revisions due to early femoral failure showed them to be more common in patients who had undergone the direct anterior approach (57/112; 50.9%) than in those treated with the direct lateral (39/112; 34.8%) or the posterior (16/112; 14.3%) approach (p = 0.001). In multivariate regression analysis controlling for age, sex, laterality, Dorr bone type, body mass index (BMI) at revision, bilateral procedure (yes/no), and femoral stem type, the direct anterior approach remained a significant predictor of early femoral failure (p = 0.007). The majority of early revisions due to instability were associated with the posterior (19/40; 47.5%) or direct anterior (15/40; 37.5%) approach (p = 0.001 for the comparison with the direct lateral approach [6/40; 15.0%]). Conclusions Despite claims of earlier recovery and improved outcomes with the direct anterior approach for THA, our findings indicate that that approach may confer a greater risk of early femoral failure and, along with the posterior approach, confer a greater risk of early instability compared with the direct lateral approach. Level of evidence Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
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- 2017
34. The effects of Hurricane Sandy on trauma center admissions
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Jaroslaw W Bilaniuk, Zoltán Németh, Terrence Curran, Addison S. Hicks, John M Adams, Dorian A. Bogdanovski, Louis T. DiFazio, Brian K Siegel, and Renay Durling-Grover
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Male ,medicine.medical_specialty ,animal diseases ,0211 other engineering and technologies ,Poison control ,02 engineering and technology ,Critical Care and Intensive Care Medicine ,Occupational safety and health ,03 medical and health sciences ,0302 clinical medicine ,Trauma Centers ,Injury prevention ,medicine ,Humans ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Retrospective Studies ,021110 strategic, defence & security studies ,New Jersey ,business.industry ,Cyclonic Storms ,Trauma center ,Storm ,Middle Aged ,medicine.disease ,Hospitalization ,Falling (accident) ,Emergency medicine ,Emergency Medicine ,Injury Severity Score ,Wounds and Injuries ,Surgery ,Female ,Medical emergency ,medicine.symptom ,Tropical cyclone ,business - Abstract
Hurricane Sandy was a particularly unusual storm with regard to both size and location of landfall. The storm landed in New Jersey, which is unusual for a tropical storm of such scale, and created hazardous conditions which caused injury to residents during the storm and in the months following. This study aims to describe differences in trauma center admissions and patterns of injury during this time period when compared to a period with no such storm. Data were collected for this study from patients who were admitted to the trauma center at Morristown Medical Center during Hurricane Sandy or the ensuing cleanup efforts (patients admitted between 29 October 2012 and 27 December 2012) as well as a control group consisting of all patients admitted to the trauma center between 29 October 2013 and 27 December 2013. Patient information was collected to compare the admissions of the trauma center during the period of the storm and cleanup to the control period. A total of 419 cases were identified in the storm and cleanup period. 427 were identified for the control. Striking injuries were more common in the storm and cleanup group by 266.7% (p = 0.0107); cuts were more common by 650.8% (p = 0.0044). Medical records indicate that many of these injuries were caused by Hurricane Sandy. Self-inflicted injuries were more common by 301.3% (p = 0.0294). There were no significant differences in the total number of patients, mortality, or injury severity score between the two cohorts. The data we have collected show that the conditions caused by Hurricane Sandy and the following cleanup had a significant effect on injury patterns, with more patients having been injured by being struck by falling or thrown objects, cut while using tools, or causing self-inflicted injuries. These changes, particularly during the cleanup period, are indicative of environmental changes following the storm which increase these risks of injury.
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- 2016
35. Echocardiographic MRI: an innovative fusion of functional and anatomic assessment strategy for CHD
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Stephanie A Raymundo, Anthony C. Chang, and Addison S. Gearhart
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Male ,medicine.medical_specialty ,Adolescent ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,cardiovascular diseases ,Tetralogy of Fallot ,Heart Valve Prosthesis Implantation ,Pulmonary Valve ,Image fusion ,business.industry ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Pulmonary Valve Insufficiency ,medicine.anatomical_structure ,030228 respiratory system ,Echocardiography ,Pulmonary valve ,Pediatrics, Perinatology and Child Health ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
We present a pilot case using an innovative fusion of echocardiogram and MRI achieved with a MATLAB-based imaging programme to explore the feasibility of this imaging strategy in the functional and anatomic assessment of a patient with repaired tetralogy of Fallot requiring pulmonary valve intervention. Echocardiogram and MRI neutralises the disadvantages and limitations of each individual imaging modality and yields important anatomic and haemodynamic information crucial to the treatment decision-making process. Future image fusion strategies can apply to three-dimensional images and image-directed therapy for CHD.
- Published
- 2018
36. On Performing Reinfibulation in Catholic Hospitals.
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Tenorio, Addison S.
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FEMALE genital mutilation , *HOSPITAL mergers , *CATHOLIC bishops , *SEXUAL ethics , *WOMEN'S hospitals , *NATURAL law - Abstract
Female genital mutilation/cutting is a multifaceted, culturally entrenched issue. In response to the United States Conference of Catholic Bishops' resources dealing with the issue of FGM/C, this paper explores what resources sexual ethics can provide Catholic hospitals facing this issue, specifically with regards to the request for reinfibulation (the restoration of infibulation, also called FGM Type III). FGM/C ought not to be treated as a univocal medical practice; rather, in natural law evaluations of the act, the practice of reinfibulation ought to be separately acknowledged. Reinfibulation cannot be properly considered a mutilation in the same way that other types of FGM/C are. Thus reinfibulation should be performed in Catholic hospitals for those women who request it, as part of delivering culturally competent care, justifiable through the principle of material cooperation. [ABSTRACT FROM AUTHOR]
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- 2020
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- View/download PDF
37. Echocardiographic MRI: an innovative fusion of functional and anatomic assessment strategy for CHD
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Gearhart, Addison S., primary, Raymundo, Stephanie A., additional, and Chang, Anthony C., additional
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- 2018
- Full Text
- View/download PDF
38. Outcome and Cost Analysis of Hand-Sewn and Stapled Anastomoses in the Reversal of Loop Ileostomy
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Nemeth, Zoltan H., primary, Bogdanovski, Dorian A., additional, Hicks, Addison S., additional, Paglinco, Samantha R., additional, Sawhney, Rohan, additional, Pilip, Stefanie A., additional, Stopper, Patricia B., additional, and Rolandelli, Rolando H., additional
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- 2018
- Full Text
- View/download PDF
39. Adolescent Attitudes Toward Sexually Transmitted Infection Screening in the Emergency Department
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Gearhart, Addison S., primary, Badolato, Gia M., additional, and Goyal, Monika K., additional
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- 2018
- Full Text
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40. Effect of Dynamic Culture and Periodic Compression on Human Mesenchymal Stem Cell Proliferation and Chondrogenesis
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Ting Guo, John P. Fisher, Bao-Ngoc B. Nguyen, Adam H. Hsieh, Jesse K. Placone, Addison S. Goodley, Casey G. Lim, Xuan Xiao, Li Yu, and Kimberly M. Ferlin
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0301 basic medicine ,Compressive Strength ,Population ,Biomedical Engineering ,Type II collagen ,Cell Culture Techniques ,Article ,Extracellular matrix ,03 medical and health sciences ,Humans ,Mesenchymal stem cell proliferation ,education ,Aggrecan ,Cell Proliferation ,education.field_of_study ,Chemistry ,Mesenchymal stem cell ,Mesenchymal Stem Cells ,Chondrogenesis ,Antigens, Differentiation ,Cell biology ,030104 developmental biology ,Gene Expression Regulation ,Cell culture ,Biomedical engineering - Abstract
We have recently developed a bioreactor that can apply both shear and compressive forces to engineered tissues in dynamic culture. In our system, alginate hydrogel beads with encapsulated human mesenchymal stem cells (hMSCs) were cultured under different dynamic conditions while subjected to periodic, compressive force. A customized pressure sensor was developed to track the pressure fluctuations when shear forces and compressive forces were applied. Compared to static culture, dynamic culture can maintain a higher cell population throughout the study. With the application of only shear stress, qRT-PCR and immunohistochemistry revealed that hMSCs experienced less chondrogenic differentiation than the static group. The second study showed that chondrogenic differentiation was enhanced by additional mechanical compression. After 14 days, alcian blue staining showed more extracellular matrix formed in the compression group. The upregulation of the positive chondrogenic markers such as Sox 9, aggrecan, and type II collagen were demonstrated by qPCR. Our bioreactor provides a novel approach to apply mechanical forces to engineered cartilage. Results suggest that a combination of dynamic culture with proper mechanical stimulation may promote efficient progenitor cell expansion in vitro, thereby allowing the culture of clinically relevant articular chondrocytes for the treatment of articular cartilage defects.
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- 2015
41. CO2 Dry Cleaning: A Benign Solvent Demonstration Accessible to K–8 Audiences
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Hudson, Reuben, primary, Ackerman, Henry M., additional, Gallo, Lindsay K., additional, Gwinner, Addison S., additional, Krauss, Anna, additional, Sears, John D., additional, Bishop, Alexandra, additional, Esdale, Kristin N., additional, and Katz, Jeffrey L., additional
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- 2016
- Full Text
- View/download PDF
42. Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial)
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Ravikumar, R., Bartlett, D., Morton, D., Berkman, L., Bodenham-Chilton, H., Deeks, J. J., Handley, K., Magill, L., Hamilton, E., Hepburn, E., Hwang, M-J, Mirza, N., Wilkey, A., Magill, M. le Breuilly L., Wilcockson, A., Mehta, S., Burtenshaw, A., Hawkins, W., Voysey, M., Blazeby, J., Smith, I., Stocken, D., Abbott, S., Hwang, M., Karim, A., Luke, D. P., McArthur, D., Mistry, P., Richardson, J., Youssef, H., Ravi, K., Goodfellow, P. B., Gupta, R., Joy, H., Eardley, N., McFaul, C., Vimalachandran, D., Harmston, C., Froggatt, P., Krishnan, P., Pathare, S., Shanmugam, V., Yiannakou, Y. J., Fawole, A., Macklin, C., Mcenhill, J., Narula, H., Riad, T., Rose, A., Chambers, J., Ekere, C., Hough, M., Hull, J., Knight, H. P., Lamparelli, M. J., Lewis, M., Pulletz, M., Siddiqi, N., Stubbs, B., Subramanian, K., Swanton, R., Costigan, S., O'Connell, G., Patel, P. K., Ali, A., Ang, C., Chapman, M. A. S., Shariff, U., Thompson, C., Yates, A. Williamson J., Leinhardt, D. J., Simenacz, M., Harris, S., Loveless, P., Mohsen, Y., Myers, A., Prabhudesai, A., Vanagov, S., Aryal, K., Lal, R., Millican, D., Panagiotopopoulou, I., Shankar, K., Dube, M., Tansley, J., Hill, J., Addison, S., Church, R., Nath, J., Valap, S., Dhrampal, A., Nortje, J., Payne, J., Sargen, K., Speakman, C., Deloughry, J., Elkington, T., Dennis, R., Ghosh, S., Martin, J., Stoker, M., Akerman, N., Basheer, M., Drury, N., Parchment-Smith, C., Sandhu, R., Srinivasa, R., Varma, S., Walwyn, S., Syed, N., Bromilow, J., Colling, P., Reschreiter, H., Senapati, A., Howse, F., Tzouliadis, L., Bach, S., Brookes, A., Cagigas, C., Dimitriou, N., Fallis, S., Futaba, K., Hill, A., Izbal, A., Leong, K., Manji, M., Milns, P., Murray, A., Nicol, D., Pinkney, T., Ramcharam, S., Royle, T. J., Scarpinata, R., Smart, C., Smart, S., Suggett, N., Sutherland, S., Tam, Y. H. M., Torrance, A., Wall, M., Vakis, S., Bassuini, M., Garner, J., Maz, S., Mottahedeh, M., Smith, M., Withers, M., Krishnamourthy, R., Paraoan, M., Thomas, P., Chesshire, N., Davies, S., Gold, S., Hamzah, I., Hurst, N., Khoo, C. K., Kiani, S., Liptrot, S., Lund, J., Millard, C., Morris, C., Reynolds, J. R., Selvaraj, I., Simpson, A., Speake, W., Tou, S., Chambers, W., Gee, A. S., Grice, A., Johnston, D., Miller, Q., Pittman, J., Price, D., Telford, R., Barrow, E., Coldwell, C., Crighton, I., Raymond, T., Richmond, S., Cheetham, M., Kulemeka, G., Carraretto, M., Huddart, S., Kirk-Bayley, J., Moor, D., Scott, M., Asif, M., Awan, R., Bethune, R., Chadwick, M., Cook, T., Courtney, E., Dalton, S., Lim, A., Williamson, M. E. R., Wood, J., Scott, R., Branagan, G., Bellin, J., Browning, D., Bulso, V., Carter, N., Cruikshank, N., Gill, K., Hulme, N., Leno, E., Newbould, D., Thumbe, V., Sankar, K., Sivasubramaniam, S., Wakhle, R., Walton, R., Zulueta, L., Ahmad, S. M., Kaur, G., Longbottom, D., Nnaji, M., Ramamoorthy, A., Thomas, J., Botteril, I., Miskovic, D., Sagar, P. M., Bhuptani, S., Kennedy, R., Jenkins, I., Littler, S., Arnold, G., Buchanan, G., Con, A., Dawson, P., Lawrie, S., Lowe, J., Malhotra, S., Paraskeva, P., Richards, S., Sidhu, V., Ziprin, P., Kruchek, D., Kuttler, A., Mohammad, K., Nasser, T., Rehman, H., Siddiqui, K., Siddiqui, A., Sindhu, Q., Soliman, M., Solkar, M., Thota, S., Renehan, A., Selvasekar, C., Melsom, H., Agarwal, A. K., Borowski, D., Brohi, F., Garg, D., Gill, T., Mahadevan, V., Sharma, A., Tabaqchali, M. A., Alce, T., Navapurkar, A., Page, V., Stambach, T., Capozzi, P., Coe, P., Conroy, P., Duff, S., Grey, T., Hill, O., Nicholson, J., Nolan, D., Pollard, J., Ramesh, A., Sabar, M., Telford, K., Davies, D., Wilson, J., and Yates, D.
- Subjects
Adult ,Male ,medicine.medical_specialty ,Treatment outcome ,Dexamethasone ,law.invention ,Eating ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Double-Blind Method ,Randomized controlled trial ,Preanesthetic Medication ,030202 anesthesiology ,law ,medicine ,Humans ,Postoperative Period ,030212 general & internal medicine ,Young adult ,Aged ,Aged, 80 and over ,business.industry ,Research ,Standard treatment ,Recovery of Function ,General Medicine ,Length of Stay ,Middle Aged ,Surgery ,Intestines ,Treatment Outcome ,Multicenter study ,Anesthesia ,Injections, Intravenous ,Postoperative Nausea and Vomiting ,Antiemetics ,Female ,medicine.symptom ,business ,Postoperative nausea and vomiting ,medicine.drug - Abstract
Objectives To determine whether preoperative dexamethasone reduces postoperative vomiting in patients undergoing elective bowel surgery and whether it is associated with other measurable benefits during recovery from surgery, including quicker return to oral diet and reduced length of stay. Design Pragmatic two arm parallel group randomised trial with blinded postoperative care and outcome assessment. Setting 45 UK hospitals. Participants 1350 patients aged 18 or over undergoing elective open or laparoscopic bowel surgery for malignant or benign pathology. Interventions Addition of a single dose of 8 mg intravenous dexamethasone at induction of anaesthesia compared with standard care. Main outcome measures Primary outcome: reported vomiting within 24 hours reported by patient or clinician. Secondary outcomes: vomiting with 72 and 120 hours reported by patient or clinician; use of antiemetics and postoperative nausea and vomiting at 24, 72, and 120 hours rated by patient; fatigue and quality of life at 120 hours or discharge and at 30 days; time to return to fluid and food intake; length of hospital stay; adverse events. Results 1350 participants were recruited and randomly allocated to additional dexamethasone (n=674) or standard care (n=676) at induction of anaesthesia. Vomiting within 24 hours of surgery occurred in 172 (25.5%) participants in the dexamethasone arm and 223 (33.0%) allocated standard care (number needed to treat (NNT) 13, 95% confidence interval 5 to 22; P=0.003). Additional postoperative antiemetics were given (on demand) to 265 (39.3%) participants allocated dexamethasone and 351 (51.9%) allocated standard care (NNT 8, 5 to 11; P
- Published
- 2017
43. Comparison of the Expression of Metalloproteinases and their Tissue Inhibitors in Ulcerative Colitis and Colon Diverticulitis
- Author
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Nemeth, Zoltan, primary, Barratt-Stopper, Patricia, additional, Hicks, Addison S., additional, Difazio, Louis T., additional, and Rolandelli, Rolando H., additional
- Published
- 2016
- Full Text
- View/download PDF
44. Quantification of maceration changes using post mortem MRI in fetuses
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Montaldo, P., primary, Addison, S., additional, Oliveira, V., additional, Lally, P. J., additional, Taylor, A. M., additional, Sebire, N. J., additional, Thayyil, S., additional, and Arthurs, O. J., additional
- Published
- 2016
- Full Text
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45. Effect of Dynamic Culture and Periodic Compression on Human Mesenchymal Stem Cell Proliferation and Chondrogenesis
- Author
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Guo, Ting, primary, Yu, Li, additional, Lim, Casey G., additional, Goodley, Addison S., additional, Xiao, Xuan, additional, Placone, Jesse K., additional, Ferlin, Kimberly M., additional, Nguyen, Bao-Ngoc B., additional, Hsieh, Adam H., additional, and Fisher, John P., additional
- Published
- 2015
- Full Text
- View/download PDF
46. Comparison of the Expression of Metalloproteinases and their Tissue Inhibitors in Ulcerative Colitis and Colon Diverticulitis
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Addison S. Hicks, Patricia Barratt-Stopper, Louis T. DiFazio, Zoltan H. Nemeth, and Rolando H. Rolandelli
- Subjects
medicine.medical_specialty ,business.industry ,General surgery ,Internal medicine ,Colon diverticulitis ,Medicine ,Surgery ,Matrix metalloproteinase ,business ,medicine.disease ,Ulcerative colitis ,Gastroenterology - Published
- 2016
47. Paper #19 Use of Ultrasonic Structural Health Monitoring to Assess the Integrity of Growing Rods
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Adam H. Hsieh, Bilal A. Naved, Matthew E. Oetgen, Addison S. Goodley, and Byungseok Yoo
- Subjects
business.industry ,Mechanical engineering ,Medicine ,Orthopedics and Sports Medicine ,Ultrasonic sensor ,Structural health monitoring ,business ,Rod - Published
- 2015
48. Mechanistic Analysis of the VirA Sensor Kinase in Agrobacterium tumefaciens Using Structural Models
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Addison Swackhammer, Edward A. P. Provencher, Akua K. Donkor, Jessica Garofalo, Sinead Dowling, Kathleen Garchitorena, Ahkar Phyo, Nicky Ramírez Veliz, Matthew Karen, Annie Kwon, Rich Diep, Michael Norris, Martin K. Safo, and B. Daniel Pierce
- Subjects
VirA ,two-component system ,AlphaFold ,Agrobacterium tumefaciens ,histidine kinase ,Microbiology ,QR1-502 - Abstract
Agrobacterium tumefaciens pathogenesis of plants is initiated with signal reception and culminates with transforming the genomic DNA of its host. The histidine sensor kinase VirA receives and reacts to discrete signaling molecules for the full induction of the genes necessary for this process. Though many of the components of this process have been identified, the precise mechanism of how VirA coordinates the response to host signals, namely phenols and sugars, is unknown. Recent advances of molecular modeling have allowed us to test structure/function predictions and contextualize previous experiments with VirA. In particular, the deep mind software AlphaFold has generated a structural model for the entire protein, allowing us to construct a model that addresses the mechanism of VirA signal reception. Here, we deepen our analysis of the region of VirA that is critical for phenol reception, model and probe potential phenol-binding sites of VirA, and refine its mechanism to strengthen our understanding of A. tumefaciens signal perception.
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- 2022
- Full Text
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49. Feasibility study from a randomized controlled trial of standard closure of a stoma site vs biological mesh reinforcement.
- Author
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Pallan, A., Patel, A., Lamparelli, M. J., Lewis, M., Subramanian, K., Chaudhri, S., Addison, S., Church, R., Adedeji, O., Bach, S., Ford, C., Cagigas, C., Dimitriou, N., Fallis, S., Futaba, K., Ismail, T., Keh, C., Morton, D., Nepogodiev, D., and Nicol, D.
- Subjects
STOMATA ,RANDOMIZATION (Statistics) ,RANDOMIZED controlled trials ,FUNGATING wounds ,FEASIBILITY studies - Abstract
Aim Hernia formation occurs at closed stoma sites in up to 30% of patients. The Reinforcement of Closure of Stoma Site ( ROCSS) randomized controlled trial is evaluating whether placement of biological mesh during stoma closure safely reduces hernia rates compared with closure without mesh, without increasing surgical or wound complications. This paper aims to report recruitment, deliverability and safety from the internal feasibility study. Method A multicentre, patient and assessor blinded, randomized controlled trial, delivered through surgical trainee research networks. A 90-patient internal feasibility study assessed recruitment, randomization, deliverability and early (30 day) safety of the novel surgical technique (ClinicalTrials.gov registration number NCT02238964). Results The feasibility study recruited 90 patients from the 104 considered for entry (45 to mesh, 45 to no mesh). Seven of eight participating centres randomized patients within 30 days of opening. Overall, 41% of stomas were created for malignant disease and 73% were ileostomies. No mesh-specific complications occurred. Thirty-one postoperative adverse events were experienced by 31 patients, including surgical site infection (9%) and postoperative ileus (6%). One mesh was removed for re-access to the abdominal cavity, for reasons unrelated to the mesh. Independent review by the Data Monitoring and Ethics Committee of adverse event data by treatment allocation found no safety concerns. Conclusion Multicentre randomization to this trial of biological mesh is feasible, with no early safety concerns. Progression to the full Phase III trial has continued. ROCSS shows that trainee research networks can efficiently develop and deliver complex interventional surgical trials. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
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50. Using Structural Equation Modeling to Understand Interactions Between Bacterial and Archaeal Populations and Volatile Fatty Acid Proportions in the Rumen
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Veronica Kaplan-Shabtai, Nagaraju Indugu, Meagan Leslie Hennessy, Bonnie Vecchiarelli, Joseph Samuel Bender, Darko Stefanovski, Camila Flavia De Assis Lage, Susanna Elisabeth Räisänen, Audino Melgar, Krum Nedelkov, Molly Elizabeth Fetter, Andrea Fernandez, Addison Spitzer, Alexander Nikolov Hristov, and Dipti Wilhelmina Pitta
- Subjects
dairy cows ,host-microbe interactions ,inter-species hydrogen transfer ,metabolically- active microbes ,microbial syntrophy ,rumen microbiota ,Microbiology ,QR1-502 - Abstract
Microbial syntrophy (obligate metabolic mutualism) is the hallmark of energy-constrained anaerobic microbial ecosystems. For example, methanogenic archaea and fermenting bacteria coexist by interspecies hydrogen transfer in the complex microbial ecosystem in the foregut of ruminants; however, these synergistic interactions between different microbes in the rumen are seldom investigated. We hypothesized that certain bacteria and archaea interact and form specific microbial cohorts in the rumen. To this end, we examined the total (DNA-based) and potentially metabolically active (cDNA-based) bacterial and archaeal communities in rumen samples of dairy cows collected at different times in a 24 h period. Notably, we found the presence of distinct bacterial and archaeal networks showing potential metabolic interactions that were correlated with molar proportions of specific volatile fatty acids (VFAs). We employed hypothesis-driven structural equation modeling to test the significance of and to quantify the extent of these relationships between bacteria-archaea-VFAs in the rumen. Furthermore, we demonstrated that these distinct microbial networks were host-specific and differed between cows indicating a natural variation in specific microbial networks in the rumen of dairy cows. This study provides new insights on potential microbial metabolic interactions in anoxic environments that have broader applications in methane mitigation, energy conservation, and agricultural production.
- Published
- 2021
- Full Text
- View/download PDF
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