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A highly cited paper is seen as a landmark in any field and can influence both research and clinical practice. This study aimed to quali-quantitatively analyze the 100 most-cited papers in Cariology. A search strategy was first determined using specific keywords related to the field. A comprehensive search was then conducted in the Thompson Reuters Web of Science citation indexing database up to April 2019. Papers focused on any aspect of Cariology were included. A panel of 4 researchers conducted the selection of papers and extracted data on the number of citations, title, authors, country, year, journals, study design, and topic of interest. Scopus and Google Scholar were also searched to compare the number of citations. The VOSviewer software was used to generate bibliometric networks. The number of citations among the top 100 most-cited papers ranged from 168 to 1,961 with a mean of 292,66. Three papers had more than 1,000 citations. The Journal of Dental Research (20%) and Caries Research (17%) had more top papers. The oldest and the most recent papers were published in 1960 and 2015. Literature reviews (35%) and laboratorial studies (31%) were the most common study designs. The countries with the highest number of most-cited papers were the USA (40%), Sweden (10%), and Japan (9%). The most studied fields of interest were etiology/pathogenesis (41%) and prevention (20%). VOSviewer maps revealed collaborative networks between countries and organizations. The top 100 most-cited papers in Cariology were published mainly by European and Anglo-Saxon American authors and were composed mainly of literature reviews with etiology/pathogenesis as the most frequent topic of interest., (© 2020 S. Karger AG, Basel.)

This study explores the prevalence of postdoctoral fellows in fast-moving and competitive scientific research. We use the results of a new and original large-scale survey of scientists in Japan and the United States for the analyses. Descriptive statistics show that, in both Japan and the United States: (1) the mean citation time lag was shorter by about 2 years in the highly cited papers (top 1 %) compared to other normal papers; and (2) the perceived degree of competitive threat was also higher for the projects producing the highly cited papers compared to those for normal papers. We also found that the likelihood of participation of postdoctoral fellows is significantly higher in research with shorter mean time lag and higher competitive threat (while that of students is not), controlling for author size, suggesting that postdoctoral fellows are especially prevalent in research efforts in fast-moving and competitive scientific research. [ABSTRACT FROM AUTHOR]

This paper examined mixed reality research published during 1994-17, on a series of bibliometric measures including growth rate, global share, citation impact, top countries, organizations and authors, preferred media of research communication and bibliographic characteristics of high cited papers. The study finds that mixed reality research registered faster (35.49%) growth, low citation impact averaged to (6.93) citations per paper, contributed too low share (0.03%) of its total research output in 24 years as highly cited papers. The USA, Japan, and Germany are seen as the world leaders in the subject, each had contributed at least 11% global publications share in 24 years. The mixed reality research is widely scattered across 68 countries with top most productive organizations and authors accounting for modest (23.35% and 16.56%) global publications share and modest (29.53% and 24.37%) global citation share respectively during the period. [ABSTRACT FROM AUTHOR]

Background: Dementia involves a progressive decline in many functional areas. Policy and practice guidelines should cover the entire course of the disease from early detection to the end-of-life. The present study aimed to evaluate the contents of national dementia strategies with a focus on palliative care content., Methods: We employed qualitative content analyses. Sixteen national dementia strategies from 14 countries were reviewed. Using open coding, the contents were compared to the domains and recommendations of the palliative care in dementia white paper of the European Association for Palliative Care (EAPC)., Results: Although palliative care was not explicitly referred to in eight of the 14 countries and only to a limited extent in three countries, a number of domains from the EAPC white paper were well represented, including "person-centered care, communication, and shared decision making"; "continuity of care"; and "family care and involvement." Three countries that referred to palliative care did so explicitly, with two domains being well represented: "education of the health care team"; and "societal and ethical issues." The strategies all lacked reference to the domain of "prognostication and timely recognition of dying" and to spiritual caregiving., Conclusions: National dementia strategies cover part of the recent definition of palliative care in dementia, although they do not frequently label these references as "palliative care." In view of the growing numbers of people dying with dementia, preparation for the last phase of life should be added to national strategies.

This reflective paper shares the experiences of a higher education professional living and working abroad and the long-term impacts of those experiences on their self-authorship journey through reflection ten years later. The story of this reflection focuses on how cultural differences and community ties helped to facilitate growth and self-confidence through navigating the challenges and complexities of living abroad in a culture with differing conventions. The paper concludes by sharing how reflecting on self-authorship during and after international experiences can help develop personal identities both as an individual and within a collective.

Objective. To sort out the literature related to conjunctival bacteria and summarize research hotspots and trends of this field. Materials and Methods. The relevant literature data from 1900 to 2019 was retrieved from the Web of Science Core Collection database. After manual selection, each document record includes title, author, keywords, abstract, year, organization, and citation. We imported the downloaded data into CiteSpace V (version 5.5R2) to draw the knowledge map and conduct cooperative network analysis, discipline and journal analysis, cluster analysis, and burst keyword analysis. Results. After manual screening, there were 285 relevant papers published in the last 28 years (from 1991 to 2019), and the number is increasing year by year. The publications of conjunctival bacteria were dedicated by 1381 authors of 451 institutions in 56 countries/regions. The United States dominates this field (82 literatures), followed by Germany (23 literatures) and Japan (23 literatures). Overall, most cited papers were published with a focus on molecular biology, genetics, nursing, and toxicology. Most papers fall into the category of ophthalmology, veterinary sciences, and pharmacology and pharmacy. The only organized cluster is the "postantibiotic effect," and the top 5 keywords with the strongest citation bursts include "postoperative endophthalmiti(s)," "infectious keratoconjunctiviti(s)," "conjunctiviti(s)," "resistance," and "diversity". Conclusion. The global field of conjunctival bacteria has expanded in the last 28 years. The United States contributes most. However, there are little cooperation among authors and institutions. Overall, this bibliometric study organized one cluster, "postantibiotic effect", and identified the top 5 hotspots in conjunctival bacteria research: "postoperative endophthalmiti(s)," "infectious keratoconjunctiviti(s)," "conjunctiviti(s)," "resistance," and "diversity". Thus, further research focuses on these topics that may be more helpful to prevent ocular infection and improve prophylaxis strategies to bring a benefit to patients in the near future. [ABSTRACT FROM AUTHOR]

This paper demonstrates that when one new job is generated by attracting a new business in the tradable sector in a local economy, a significant number of additional jobs are created in the nontradable sector when labor mobility is high. However, these multipliers disappear when labor mobility is low. This paper confirms that regions with higher labor inflow have larger multipliers. Furthermore, the spillover effect of agglomeration economies in the tradable sector is significantly positive on the nontradable sector. [ABSTRACT FROM AUTHOR]

Objective: To determine impact of undertaking an international educational program during a nurse's or midwife's pre-registration program on subsequent practice, focusing on how nurses and midwives were transformed personally through participation in such programs. Background: Participation in international educational programs has been reported to enhance nursing and midwifery students' personal and professional development, however long-term impacts remain unclear. This paper presents findings drawn from a larger grounded theory study. Study design and Methods: Charmaz's grounded theory methodology was used to elicit experiences from 13 general nurses, two mental health nurses, three midwives and four dual qualified nurse/midwives across eight different countries. Data analysis led to the creation of three categories, with this paper reporting on the category of Developing as a Person. Findings: Participation in international educational programs can be transformative for nurses and midwives with long-lasting impacts, contributing positively to their personal growth and development. Discussion: The study findings underscore significant long-term impacts of international educational programs for nurses and midwives. These outcomes highlight the importance of incorporating international experiences into healthcare education. Conclusion: By providing opportunities for healthcare professionals to engage with diverse settings and populations, organisations and educational institutions can foster the development of well-rounded and globally competent practitioners. Implications for research, policy, and practice: The study's findings hold significant implications for research, policy, and practice in healthcare education. To deepen our understandings, additional longitudinal research across diverse countries is warranted. Policymakers have an opportunity to acknowledge the positive impact of these programs on the personal growth and development of nurses and midwives, potentially leading to the integration of global competency requirements into licensure programs. In order to provide comprehensive education, educational institutions should consider the inclusion of study abroad opportunities, cultural exchanges, and global clinical placements within nursing and midwifery curricula. What is already known about the topic? • International educational programs are widely used as a way of developing nursing and midwifery students' cultural understandings. • Previous studies have reported on short-term impacts of international educational programs. What this paper adds: • Long-term impacts of participation in an international educational program on nurses and midwives are described. • Personal development and subsequent transformations occur for nurses and midwives as a result of participation in international educational programs. [ABSTRACT FROM AUTHOR]

The emigration of scientists facilitates the formation of international networks. However, are ties in such networks maintained after the scientists return to their respective home countries? Using data from the Web of Science, this paper analyzes whether Japanese migrant scientists returning from the US maintain the collaborative research network ties that they formed during their stay in the US and, if so, what features of these ties contribute to maintaining these relationships. The geographical distance between the US and Japan can impede the transfer of knowledge that is transmitted most effectively through face-to-face interactions. However, social proximity may compensate for geographical distance. Accordingly, the ties that Japanese scientists have formed with other Japanese scientists living in the US are more likely to be maintained than the ties that they have formed with scientists of different ethnicities. Social proximity was also measured by past experiences in collaborative research. The ties to scientists with whom Japanese scientists collaborated more frequently or co-produced papers with higher citation counts are more likely to be maintained after the scientists return to Japan. When collaborative research of American and Japanese scientists is worthwhile, they obtain mutual benefits through a 'give and take' in which they compensate for one partner's lack of knowledge by the other partner's knowledge. In a research field with which the developmental gap between the US and Japan is great, ties are less likely to be maintained. [ABSTRACT FROM AUTHOR]

The OLMAR method, which stands for the on-line moving average reversion method, is reported to be one of the most powerful among portfolio selection algorithms in the stock markets. In this research, we use intensive statistical and simulation analyses of long-term data on stock market changes to uncover the secrets of why and when the superiority appears. We find that there have been long-lasting fluctuations in the stock markets and that the OLMAR method actively makes use of such characteristics. In this paper, we analyze long-term stock data from Japan and the United States. The analyses confirm the following points. 1) The OLMAR method yields superior returns. 2) By using the moving average divergence rate provided by the OLMAR method, it is possible to detect specific fluctuation characteristics in long-term stock data from Japan and the United States. 3) Superior returns cannot be obtained from data in which specific fluctuation characteristics have been corrected. [ABSTRACT FROM AUTHOR]

The term “bourbon” has become increasingly popular in markets all over the globe. The popularity of the bourbon trend has been exploited for both labelling liquors and describing nonalcoholic products. Bourbon has several separate definitions, usually differing on the issue of the geographical scope of the spirit’s production. The bourbon liquor industry has experienced periods of significant downturn followed by periods of explosive revival, motivated mainly by foreign interest, from countries such as Japan, in the product In the 1970s, Japanese interest in whisky and US bourbon facilitated a resurgence of the then-struggling US bourbon industry. In 2018, production of bourbon reached its highest level since 1972. Compared to the exports of 1997, bourbon exports to foreign countries tripled in volume and price in 2018 There are minimal legal protections currently available to America’s bourbon producers to insulate their unique spirit from foreign competition. Despite successful adoption and use of geographical indications (GIs) in many countries, the United States has avoided employing GIs to insulate local products in international markets, with the exception of a few protections for regionally produced wines. GIs have been gaining significance as accessibility to international markets has increased substantially in recent years. In 2015, Japan joined the GI trend, agreeing to recognize GIs with the EU. Products such as Scotch whisky are recognized and protected as GIs in Japan. The previous year, the Japanese company Suntory acquired Jim Beam, a Kentucky-based company comprised of several well-known bourbon labels. The relationship between the US bourbon and Japanese whisky markets has a long history and an arguably longer future ahead. Many of the arguments for the use of GIs have not been updated since countries such as Japan joined the international trend towards GI adoption. Thus, this paper will use the bourbon industry as an example to illustrate and further arguments presented by advocates of GIs. Looking to the successful adoption of GI agreements in Japan, this paper will highlight the benefits of participation in GI recognition and advocate for the US’s entering into GI agreements with Japan and other international bodies generally. [ABSTRACT FROM AUTHOR]

Quad or Quadrilateral Security Dialogue, a group of four democracies, the US, India, Japan, and Australia, was first proposed in 2007 by Japanese Prime Minister Shinzo Abe in his 'confluence of two seas' speech that subsequently embarked on the path to the foundation of the group. Quad perceives China's economic growth, which enables her to transform the world order as a threat and aims at containing the growing Chinese assertiveness in the Indo-Pacific region. The Malabar naval exercises in the Indian Ocean by the Quad members were one such exercise. This paper, aims to analyze the formation of Quad and will contemplate whether the group is causing confrontation or stability in the Asia-Pacific and Indo-Pacific regions. The paper will also assess that the Quad is designed to counter China's growing influence in the Asia-pacific and Indo-pacific regions. Containing China is likely to create a confrontation in the region. [ABSTRACT FROM AUTHOR]

An introduction is presented in which editor discusses papers on topics including effect of unconventional monetary policy in Japan impact of quantitative easing monetary policy (QE) and effects of U.S. monetary policy which were presented at conference held at in Tokyo, Japan on March 5, 2015.

Copyright of Records Management: Journal of the Records Management Society of Japan is the property of Records Management Society of Japan and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objectives. The bibliometric analysis uses the citation count of an article to measure its impact in the scientific community, yet there is still no comprehensive summary of gastric disease researches via bibliometric analysis. We aimed to evaluate the situations and trends of the most cited articles in gastric disease via bibliometric analysis and to provide physicians a practical guide in assessing the most influential articles written on this subject. Methods. The 100 top-cited articles in gastric disease were compiled using Web of Science. The articles selected were evaluated for their number of citations, year of publication, country of origin, type of study, and others. Results. The database had 484,281 articles published between 1965 and 2019. The most cited article received 4,017 citations and the least received 604, with a mean of 1,149 citations. We classified the articles into seven categories: gastric cancer (n = 53), Helicobacter pylori (n = 17), ulcer (n = 7), gastrointestinal stromal tumors (n = 6), gastritis (n = 5), gastric bypass surgery (n = 2), and others (n = 10). Altogether, 69 of the articles were from the USA (n = 41), the UK (n = 17), and Japan (n = 11). Among all the institutions, Royal Perth Hospital led the list with 5 articles. One-quarter of authors owned three or more of these top-cited articles. The 100 papers were published in 33 journals, and most of them were clinical researches (n = 47). Conclusions. Our study provides a historical perspective for the scientific progress of gastric disease, and the articles of significant findings that contributed great impact on the prevention and treatment of gastric disease had been identified. [ABSTRACT FROM AUTHOR]

To conduct monetary policy effectively, central banks need to understand the transmission of monetary policy into financial markets. In this paper we investigate the effects of Japanese and U.S. monetary policy shocks on their own asset markets, and the spillovers into each other's markets. Because short-term nominal interest rates have been effectively zero in Japan since January 1998 and in the United States from late 2008, however, monetary policy shocks cannot be quantified by considering observable changes in short-term market interest rates. Therefore, in our analysis we use a shadow short rate-a quantitative measure of overall conventional and unconventional monetary policy that is estimated from the term structure of interest rates. Our results suggest that the operation of monetary policy at the zero lower bound of interest rates alters the transmission of shocks. In particular, we find a limited response of exchange rates during the first episode of unconventional monetary policy in Japan but a significant impact since 2006. [ABSTRACT FROM AUTHOR]

Background: A growing body of research demonstrates that adapting the popular entertainment activity "escape rooms" for educational purposes as an innovative teaching method can improve the learning experience. Escape rooms promote teamwork, encourage analytical thinking, and improve problem solving. Despite the increasing development and use of escape rooms in health sciences programs and academic libraries, there is little literature on the use of this method in health sciences libraries with health professions students. Case Presentation: Staff at a health sciences library collaborated with faculty to incorporate escape rooms into library instruction in a variety of settings (in-person, hybrid, online) and formats (team, individual) with health professions students from various disciplines (optometry, pharmacy, medicine). The escape rooms described in this paper offered unique experiences for students through active learning. Discussion: Important considerations when planning escape rooms for health sciences library instruction include deciding on team-based or individual design, calculating potential costs in time and money, deciding on an in-person, hybrid, or online format, and determining whether grades should be assigned. Escape rooms can be an effective strategy for library instruction in the health sciences, working in multiple formats to bring game-based learning to a variety of health professions students. [ABSTRACT FROM AUTHOR]

This study aims to identify the literacy skills of individuals whose highest level of education was in the field 'teacher training and educational sciences'. The study sample comprised 10,618 individuals in the field of teacher training and educational sciences, selected from 31 countries (participating in the International Adult Skills Assessment Programme during the 2014-2015 survey) using a multi-stage sampling method. The study employed multi-level latent class analysis and three-step analysis in order to determine both the number of multi-level latent classes of educators' literacy scores as well as the selected independent variables' success in predicting those latent classes. The analysis revealed that educators in Germany constituted the group with the highest literacy skills while educators from Singapore comprised the group with the lowest literacy skills. [This study was presented at the 9th International Congress of Educational Research. Ordu University, Ordu, Turkey.]

Coastal regions around the Pacific Ring of Fire share the risk of massive earthquakes and tsunamis. Along with their own political-economic, cultural and biophysical contexts, each region has their own history and experiences of tsunami disasters. Coastal areas of Washington State in the U.S. are currently at risk of experiencing a tsunami following a massive Magnitude 9 (M9) earthquake anticipated in the Cascadia Subduction Zone (CSZ). Looking ahead to consider adaptive planning in advance of a tsunami following this M9 event, this paper explores how lessons from recent megaquake- and tsunami-related experiences of risk-based planning and relocation in coastal areas of Japan and Chile could inform anticipatory action in coastal Washington State. Based on a comparison of earthquake and tsunami hazards, social factors, and the roles of government, this paper outlines a framework to compare policy contexts of tsunami risk-based planning and relocation in three Ring of Fire countries, including factors shaping the possible transfer of approaches between them. Findings suggest some aspects of comparative significance and commonalities shared across coastal communities in the three countries and at the same time highlight numerous differences in governance and policies related to planning and relocation. Although there are limitations to the transferability of lessons in disaster adaptive planning and anticipatory action from one national/regional context to another, we believe there is much more that Washington and the Pacific Northwest can learn from Japanese and Chilean experiences. In any context, risk reduction policies and actions need to garner political support in order to be implemented. Additional case study research and detailed analysis is still needed to understand specific lessons that may be applied to detailed risk-based planning and relocation programs across these different national contexts. [ABSTRACT FROM AUTHOR]

Incorporating systematic evidence with clinical expertise is a key element in the quest to improve quality of care and patient outcomes. The evidence supporting skin‐to‐skin contact in the first hour after birth is robust and includes significantly improved outcomes for both mother and infant. This paper compares available iterative data about newborn behaviour in the first hour after birth to further describe the observable behaviour pattern and to provide clinical insight for further research. Although the evidence for positive outcomes through skin‐to‐skin contact are robust, there is a dearth of research specifically focused on clinical practice. The methodology considers the four available data sets that used Widström's 9 stages, which consists of studies from Japan, Sweden, Italy and the United States, examining the parameters of each stage across settings from around the world. This research provides an expanded understanding of the timing of the newborn's progression through Widström's 9 observable stages. We found that newborns in all four data sets began with a birth cry and continued through the remaining stages of relaxation, awakening, activity, rest, crawling, familiarization, suckling and sleeping during the first hours after birth and consolidated the data into a Sign of the Stages chart to assist in further research. The evidence supports making a safe space and time for this important newborn behaviour. Clinical practices should encourage and protect this sensitive period. [ABSTRACT FROM AUTHOR]

In this paper, Teaching Expertise in Three Countries project is used as an example to show the significance and contribution of international comparative research and to think about the possible implications for policy in early childhood education. The project studied the development of expertise in preschool teaching in Japan, China, and the United States by employing 'video-cued multivocal ethnography' to explore how teaching expertise is defined in each of these countries and what processes help teachers acquire advanced teaching skills. This project has shown similarities and culturally specific notions, in what the participants have to say about characteristics of less and more experienced teachers. These research findings raise issues and challenges in early childhood education that resonate with the situation not only in the three countries but also possibly in other countries, such as problematizing the role of remembering and reflection in professional practice and the value of experience. [ABSTRACT FROM AUTHOR]

Copyright of New Architecture is the property of New Architecture Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The aim of this study is to identify the most prolific countries in the field of special education and to discuss the widespread impact of their papers by taking into account the country's h-index. Through a bibliometric analysis, the data were collected in the Web of Science Core Collection category "Education, Special" in the Social Science Citation Index during 2011-2020. The 25 most prolific countries in the field of special education were determined in terms of paper productivity, and it was seen that the leading country was undisputedly the USA (54.42%). Meanwhile, a strong positive correlation was found between the h-index and the number of papers published by the countries (r=0.864). On the other hand, when the ranking in terms of the number of papers was reconfigured by the h-index, it was relatively changed. The possible reasons for this change for the countries with the most changing rankings were discussed by considering some definitive criteria such as the journal quartiles, the percentage of international and domestic, and the percentage of open access papers. This study reports a positive correlation between the quality and quantity in the field of special education for the publications of countries. It has been shown that where the positive correlation deviates, then especially, the journal quartiles, the percentage of international collaboration and the percentage of open access papers have a significant effect. The bibliometric findings may be useful to enrich the discussion about the widespread impact of papers and debate whether the use of h-index is acceptable for cross-national comparisons.

This scoping review explores the professional literature in allied healthcare to determine which self-assessments of mentor skills are the most valid and reliable for use in occupational therapy doctoral capstone programs. The aims of this scoping review include mapping evidence related to mentor assessments in healthcare, exploring implications for occupational therapy doctoral mentor training programs, and identifying common characteristics of mentor self-assessments for occupational therapy programs to consider when developing capstone mentoring resources. Researchers applied and reported via PRISMA Extension for Scoping Reviews (PRISMA-ScR). A librarian and authors formulated keywords and database selections to search PubMed/MEDLINE/PMC, and Embase were searched from across healthcare professions for training outcomes, mentor self-assessment, mentor attributes, and use of researcher-developed assessments. The search was limited to English publications from the last 20 years. Data were extracted for quantitative information regarding study characteristics and qualitative information about mentoring skills. A total of 852 results were delivered across all databases. Nineteen papers met the final eligibility criteria and were included in the data extraction. Populations were included from several healthcare professions, including 11 nursing, four healthcare researchers, one pharmacy, one midwifery, one medicine, and one medical dietetics. Countries included the United States (n = 7), Finland (n = 5), United Kingdom (n = 4), Japan (n = 1), South Africa (n = 1) and Canada (n = 1). The authors identified four valid self-assessment tools, demonstrating III and IV levels of evidence, that may be implemented by occupational therapy programs as they develop resources for mentor programs. Occupational therapy programs can use the mentor attributes found in this scoping review to create their own mentor assessment measures or may choose to use a validated tool. The authors recommend additional research in mentor education and mentor skill acquisition. [ABSTRACT FROM AUTHOR]

The purpose of this paper is to analyze the financial turmoil of the US subprime loan crisis of mid-Noughties and to compare it with the Japanese asset bubble of late 1980s. While examining the two crises, it compares the monetary policies of both countries, focusing on the excess liquidity and expansion of bank loans that were seen. This paper develops several bubble indicators, including the ratio of real estate loans to total loans, the loan-to-GDP ratio, and housing affordability. In order to develop these indicators, it is necessary to compare banking behavior in both Japan and the United States, as banks in both countries were making loans beyond the point of profit maximization. Property prices and monetary policy in both countries influenced banking behavior significantly. The bubble indicators developed in this paper can be used as early warning indicators for future bubbles. [ABSTRACT FROM AUTHOR]

A major hurdle in pediatric formulation development is the lack of safety and toxicity data on some of the commonly used excipients. While the maximum oral safe dose for several kinds of excipients is known in the adult population, the doses in pediatric patients, including preterm neonates, are not established yet due to the lack of evidence-based data. This paper consists of four parts: (1) country-specific perspectives in different parts of the world (current state, challenges in excipients, and ongoing efforts) for ensuring the use of safe excipients, (2) comparing and contrasting the country-specific perspectives, (3) past and ongoing collaborative efforts, and (4) future perspectives on excipients for pediatric formulation. The regulatory process for pharmaceutical excipients has been developed. However, there are gaps between each region where a lack of information and an insufficient regulation process was found. Ongoing efforts include raising issues on excipient exposure, building a region-specific database, and improving excipient regulation; however, there is a lack of evidence-based information on safety for the pediatric population. More progress on clear safety limits, quantitative information on excipients of concern in the pediatric population, and international harmonization of excipients' regulatory processes for the pediatric population are required. [ABSTRACT FROM AUTHOR]

Intermediate isolation system (IIS) is currently spreading and gaining significant popularity, mainly in Japan. However, its potentials are not so well-known in European countries, and in USA only one application to building retrofit is registered. The dynamic behaviour of intermediate isolation systems, more complex than the two-degree-of-freedom behaviour of base isolation systems, gives rise to a twofold control mode, which combines isolation and mass damping strategies. However, the research contributions provided in the scientific literature usually concentrate on one single control mode, either isolation or mass damping, and the relevant design methods and criteria. This paper addresses the IIS design problem from a wider perspective and presents an explorative study on the vibration characteristics and dynamic behaviour of IIS, in order to identify the range of different behavioural modes and to propose relevant design guidelines. For these aims, a parametric analysis is carried out, varying the main design parameters, namely: isolation period and ratio, location of isolation layer and mass ratio, distributions of stiffness and mass in the upper and lower structures. A classical modal approach is initially assumed for assessing the contributions of each vibration mode on the global dynamic behaviour of IIS, with a particular focus on the effect of coupling of higher modes. However, since IIS is a non-proportionally damped system, a state space formulation is subsequently adopted for establishing the cases for which the simplified classical approach, only considering two damping values for the isolation and structural parts, can be adopted in a preliminary design stage. Finally, frequency response analysis is carried out for identifying the ranges of predominant isolation and mass damping behaviour and the effect of mode coupling both in terms of local and global response of the isolated models. Design implications are finally derived from the analysis results. [ABSTRACT FROM AUTHOR]