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A one-pot synthesis of new oxindole-fused polycyclic scaffolds is reported. The process involves a three-component [3+2] cycloaddition followed by cyclization through an intramolecular Michael addition. The reaction gives easy access to oxindole-fused spirotetrahydrofurochromans in moderate to good yields with high regio- and diastereoselectivity. These compounds could be useful for for drug discovery. Further modification was achieved by reduction of the nitro group, and intramolecular amide formation to give the corresponding lactams. The resulting heterocyclic products show good inhibitory activity against the enzyme PTP1B in vitro. [ABSTRACT FROM AUTHOR]

The chiral RhI-diene-catalyzed asymmetric three-component reaction of aryldiazoacetates, aromatic amines, and β-nitroacrylates was achieved to obtain γ-nitro-α-amino-succinates in good yields and with high diastereo- and enantioselectivity. This reaction is proposed to proceed through the enantioselective trapping of RhI-associated ammonium ylides by nitroacrylates. This new transformation represents the first example of RhI-carbene-induced ylide transformation. [ABSTRACT FROM AUTHOR]

A one-pot synthesis of new oxindole-fused polycyclic scaffolds is reported. [ABSTRACT FROM AUTHOR]

The article presents chemical equations related to the article "A Transformation of Cyclopropyl Carbene: A Highly Enantioselective Three-Component Reaction via Trapping Oxonium Ylide by Imine" by Mingfeng Li and others, published in the journal "Tetrahedron" in 2016.

The first example of chiral secondary amine and iridium(I) co-catalyzed enantioselective three-component reaction of aryldiazoacetates, indoles and enals is developed to afford 3-substituted indole derivatives in good yields and with moderate diastereoselectivity as well as excellent enantioselectivity. [ABSTRACT FROM AUTHOR]

An abstract of the article "An Ylide Transformation of Rhodium(I) Carbene: Enantioselective Three-Component Reaction Through Trapping of Rhodium(I)-Associated Ammonium Ylides by Β-Nitroacrylates" by Xiaochu Ma and colleagues is presented.

The title compounds show inhibitory activity on PTP1B and SIRT1 enzymes in vitro. [ABSTRACT FROM AUTHOR]

A four-component Mannich/cascade aza-Michael reaction using a ruthenium complex with a chiral Broensted acid is developed. [ABSTRACT FROM AUTHOR]

Ammonium ylides generated in situ from aryldiazo acetates and arylamines undergo Mannich-type reaction with N-sulfonyl aldimines to produce α,β-diamino acid derivatives. [ABSTRACT FROM AUTHOR]