1. [Risk-adapted early detection program for prostate cancer 2.0-position paper of the German Society of Urology 2024].
- Author
-
Michel MS, Gschwend JE, Wullich B, Krege S, Bolenz C, Merseburger AS, Krabbe LM, Schultz-Lampel D, König F, Haferkamp A, and Hadaschik B
- Subjects
- Male, Humans, Germany, Middle Aged, Aged, Risk Assessment methods, Urology standards, Prostatic Neoplasms diagnosis, Early Detection of Cancer methods, Prostate-Specific Antigen blood, Algorithms
- Abstract
Background and Objective: Despite the proven effectiveness of organized PSA-based screening in reducing prostate cancer-related mortality, there is currently no program in Germany covered by statutory health insurance. In accordance with the EU Council Decision (2022/0290(NLE)), the German Society of Urology (DGU) has developed a concept for risk-adapted prostate cancer early detection., Materials and Methods: Based on a literature review of current screening studies, an algorithm for PSA-based prostate cancer early detection was developed., Results: Risk-adapted prostate cancer screening involves PSA testing in the age group of 45-70 years, followed by PSA-based individual risk stratification and stepwise expansion of diagnostics through magnetic resonance imaging (MRI) to biopsy. While initially up to 2.6 million men will undergo PSA testing, a reduction in these initial examinations to fewer than 200,000 men per year will occur from year four onwards., Conclusions: The presented algorithm provides clear recommendations for risk-adapted PSA-based early detection for prostate cancer for urologists and patients. The goal is to improve diagnosis of clinically significant prostate cancer, while reducing overdiagnosis and overtreatment., (© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF