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A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit : A position paper from the Italian Group of Haematopathology (G.I.E.).
- Source :
-
Virchows Archiv : an international journal of pathology [Virchows Arch] 2019 Oct; Vol. 475 (4), pp. 513-518. Date of Electronic Publication: 2019 Aug 06. - Publication Year :
- 2019
-
Abstract
- An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical, and cytogenetic/molecular features. The diagnostic workup in such situations implies the application of costly and time-consuming analyses, which are not always required, since an intensified treatment option is reasonably reserved to fit patients. The Italian Group of Haematopathology proposes herein a practical algorithm for the diagnosis of aggressive mature B cell lymphomas based on a stepwise approach, aimed to select cases deserving molecular analysis, in order to optimize time and resources still assuring the optimal management for any patient.
Details
- Language :
- English
- ISSN :
- 1432-2307
- Volume :
- 475
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Virchows Archiv : an international journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 31388760
- Full Text :
- https://doi.org/10.1007/s00428-019-02637-2