1. Genetic variations of low-density lipoprotein cholesterol on metabolic disorders in obstructive sleep apnea.
- Author
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Peng, Yu, Shen, Hangdong, Li, Chenyang, Zhu, Xiaoyue, Gao, Yiqing, Yi, Hongliang, Xu, Huajun, Guan, Jian, Li, Xinyi, and Yin, Shankai
- Subjects
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METABOLIC syndrome risk factors , *RISK assessment , *CARDIOVASCULAR diseases , *BODY mass index , *STATISTICAL significance , *RESEARCH funding , *MULTIPLE regression analysis , *KRUSKAL-Wallis Test , *SEX distribution , *SMOKING , *LDL cholesterol , *BIOCHEMISTRY , *CARDIOVASCULAR diseases risk factors , *CHI-squared test , *MULTIVARIATE analysis , *AGE distribution , *DESCRIPTIVE statistics , *GENETIC variation , *ODDS ratio , *SLEEP apnea syndromes , *ANALYSIS of variance , *ANTHROPOMETRY , *POLYSOMNOGRAPHY , *CONFIDENCE intervals , *ALCOHOL drinking , *DATA analysis software , *SINGLE nucleotide polymorphisms , *DISEASE complications - Abstract
Background: The study aimed to explore the relationship between low-density lipoprotein cholesterol (LDL-C) genetic variants and obstructive sleep apnea (OSA) and its complications, including cardiovascular diseases (CVD), insulin resistance (IR), and metabolic syndrome (MS). Method: 4329 individuals with suspected OSA who underwent a comprehensive assessment of anthropometric, biochemical, and polysomnography (PSG) data, along with 30 LDL-C single nucleotide polymorphisms (SNPs) were enrolled. The 10-year Framingham CVD risk score (FRS), IR and MS were evaluated for each subject. Linear regression and logistic regression were utilized to examine the correlations among these variables. Results: After the Benjamini-Hochberg correction, linear regression results indicated positive correlations between variants rs3741297 and rs629301 with FRS (β = 0.031, PBH=0.002; β = 0.026, PBH=0.015). Logistic regression revealed that rs3741297 increased MS risk among total subjects [OR = 1.67 (95% CI:1.369–2.038), PBH=1.32 × 10− 5] and increased IR risk in females [OR = 3.475 (95% CI:1.653–7.307), PBH=0.03]. In males, rs2642438 decreased MS risk [OR = 0.81 (95% CI:0.703–0.933), PBH=0.045]. Conclusions: The rs3741297 variant correlated with susceptibility to CVD, IR, and MS in the OSA population. OSA, CVD, IR and MS share a potentially common genetic background, which may promote precision medicine. Cinical trial registration: The study protocol was registered with the Chinese Clinical Trial Registry (ChiCTR1900025714). [ABSTRACT FROM AUTHOR]
- Published
- 2024
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