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β cell function and insulin resistance have gender-specific correlations with carotid intima-media thickness in type 2 diabetes.
- Source :
-
International Journal of Diabetes in Developing Countries . Jun2024, Vol. 44 Issue 2, p409-416. 8p. - Publication Year :
- 2024
-
Abstract
- Objective: The relationships between carotid intima-media thickness (C-IMT) and β cell function and insulin resistance in patients with type 2 diabetes (T2D) have not been fully elucidated. This study is to investigate whether impaired glucose metabolism is etiologically associated with C-IMT in patients with T2D. Methods: The study group consisted of 490 (284 men, 206 women) participants. Venous blood specimens were obtained from all subjects for biochemical profiles after an >8-h overnight fast. C-IMT was measured as the distance between the luminal-intimal leading edge (I-line) and the medial-adventitial leading edge (M-line) on the far wall. Insulin resistance was estimated with the homeostasis model assessment of insulin resistance (HOMA-IR). The acute insulin response to arginine was calculated as the mean of the three plasma insulin levels obtained within 2, 4, and 6 min after the arginine bolus minus the pre-stimulus plasma insulin levels. Results: There was a graded increase in C-IMT values according to tertiles of HOMA-IR in men; the values of C-IMT were significantly decreased across the tertiles of acute insulin and C-peptide responses in women. Multivariate analysis revealed that HOMA-IR and age were positively associated with C-IMT among men participants, and acute insulin response and current smoking were the independent determinants of C-IMT in women. Conclusion: Early insulin response stimulated by arginine is independently associated with C-IMT in women T2D individuals, whereas insulin resistance is positively correlated with C-IMT in men T2D subjects. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CROSS-sectional method
*ARGININE
*T-test (Statistics)
*STATISTICAL significance
*RESEARCH funding
*PANCREATIC beta cells
*SEX distribution
*SMOKING
*MULTIPLE regression analysis
*MULTIVARIATE analysis
*CHI-squared test
*DESCRIPTIVE statistics
*INSULIN resistance
*BLOOD sugar
*C-peptide
*TYPE 2 diabetes
*CAROTID intima-media thickness
*CASE-control method
*ONE-way analysis of variance
*DATA analysis software
Subjects
Details
- Language :
- English
- ISSN :
- 09733930
- Volume :
- 44
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- International Journal of Diabetes in Developing Countries
- Publication Type :
- Academic Journal
- Accession number :
- 177283110
- Full Text :
- https://doi.org/10.1007/s13410-023-01260-x