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Achieving high energy density has always been the goal of lithium-ion batteries (LIBs). SiO x has emerged as a compelling candidate for use as a negative electrode material due to its remarkable capacity. However, the huge volume expansion and the unstable electrode interface during (de)lithiation, hinder its further development. Herein, we report a facile strategy for the synthesis of surface fluorinated SiO x (SiO x @vG-F), and investigate their influences on battery performance. Systematic experiments investigations indicate that the reaction between Li + and fluorine groups promotes the in situ formation of stable LiF-rich solid electrolyte interface (SEI) on the surface of SiO x @vG-F anode, which effectively suppresses the pulverization of microsized SiO x particles during the charge and discharge cycle. As a result, the SiO x @vG-F enabled a higher capacity retention of 86.4 % over 200 cycles at 1.0 C in the SiO x @vG-F||LiNi 0.8 Co 0.1 Mn 0.1 O 2 full cell. This approach will provide insights for the advancement of alternative electrode materials in diverse energy conversion and storage systems., (© 2024 Wiley-VCH GmbH.)

Lithium-sulfur batteries (LSBs) have recently gained extensive attention due to their high energy density, low cost, and environmental friendliness. However, serious shuttle effect and uncontrolled growth of lithium dendrites restrict them from further commercial applications. As "the third electrode", functional separators are of equal significance as both anodes and cathodes in LSBs. The challenges mentioned above are effectively addressed with rational design and optimization in separators, thereby enhancing their reversible capacities and cycle stability. The review discusses the status/operation mechanism of functional separators, then primarily focuses on recent research progress in versatile separators with purposeful modifications for LSBs, and summarizes the methods and characteristics of separator modification, including heterojunction engineering, single atoms, quantum dots, and defect engineering. From the perspective of the anodes, distinct methods to inhibit the growth of lithium dendrites by modifying the separator are discussed. Modifying the separators with flame retardant materials or choosing a solid electrolyte is expected to improve the safety of LSBs. Besides, in-situ techniques and theoretical simulation calculations are proposed to advance LSBs. Finally, future challenges and prospects of separator modifications for next-generation LSBs are highlighted. We believe that the review will be enormously essential to the practical development of advanced LSBs., (© 2024 Wiley-VCH GmbH.)

Organic scintillators are praised for their abundant element reserves, facile preparation procedures, and rich structures. However, the weak X-ray attenuation ability and low exciton utilization efficiency result in unsatisfactory scintillation performance. Herein, a new family of highly efficient organic phosphonium halide salts with thermally activated delayed fluorescence (TADF) are designed by innovatively adopting quaternary phosphonium as the electron acceptor, while dimethylamine group and halide anions (I - ) serve as the electron donor. The prepared butyl(2-[2-(dimethylamino)phenyl]phenyl)diphenylphosphonium iodide (C4-I) exhibits bright blue emission and an ultra-high photoluminescence quantum yield (PLQY) of 100 %. Efficient charge transfer is realized through the unique n-π and anion-π stacking in solid-state C4-I. Photophysical studies of C4-I suggest that the incorporation of I accounts for high intersystem crossing rate (k ISC ) and reverse intersystem crossing rate (k RISC ), suppressing the intrinsic prompt fluorescence and enabling near-pure TADF emission at room temperature. Benefitting from the large Stokes shift, high PLQY, efficient exciton utilization, and remarkable X-ray attenuation ability endowed by I, C4-I delivers an outstanding light yield of 80721 photons/MeV and a low limit of detection (LoD) of 22.79 nGy ⋅ s -1 . This work would provide a rational design concept and open up an appealing road for developing efficient organic scintillators with tunable emission, strong X-ray attenuation ability, and excellent scintillator performance., (© 2024 Wiley-VCH GmbH.)

Perovskite solar cells (PSCs) are usually modified and passivated to improve their performance and stability. The interface modification and bulk doping are the two basic strategies. Fluorine (F)-containing materials are highly favored because of their unique hydrophobicity and coordination ability. This review discusses the basic characteristics of F, and the basic principles of improving the photovoltaic performance and stability of PSC devices using F-containing materials. We systematically summarized the latest progress in the application of F-containing materials to achieve efficient and stable PSCs on several key interface layers. It is believed that this work will afford significant understanding and inspirations toward the future application directions of F-containing materials in PSCs, and provide profound insights for the development of efficient and stable PSCs., (© 2024 Wiley-VCH GmbH.)

In practical operating conditions, the lithium deposition behavior is often influenced by multiple coupled factors and there is also a lack of comprehensive and long-term validation for dendrite suppression strategies. Our group previously proposed an intermittent lithiophilic model for high-performance three-dimensional (3D) composite lithium metal anode (LMA), however, the electrodeposition behavior was not discussed. To verify this model, this paper presents a modified 3D carbon cloth (CC) backbone by incorporating NiFe 2 O 4 /Fe 2 O 3 (NFFO) nanoparticles derived from bimetallic NiFe-MOFs. Enhanced Li adsorption capacity and lithiophilic modulation were achieved by bimetallic MOFs-derivatives which prompted faster and more homogeneous Li deposition. The intermittent model was further verified in conjunction with the density functional theory (DFT) calculations and electrodeposition behaviors. As a result, the obtained Li-CC@NFFO||Li-CC@NFFO symmetric batteries exhibit prolonged lifespan and low hysteresis voltage even under ultra-high current and capacity conditions (5 mA cm -2 , 10 mAh cm -2 ), what's more, the full battery coupled with a high mass loading (9 mg cm -2 ) of LiFePO 4 cathode can be cycled at a high rate of 5 C, the capacity retention is up to 95.2 % before 700 cycles. This work is of great significance to understand the evolution of lithium dendrites on the 3D intermittent lithiophilic frameworks., (© 2024 Wiley-VCH GmbH.)

Gyroid, double diamond and the body-centred "Plumber's nightmare" are the three most common bicontinuous cubic phases in lyotropic liquid crystals and block copolymers. While the first two are also present in solvent-free thermotropics, the latter had never been found. Containing six-fold junctions, it was unlikely to form in the more common phases with rod-like cores normal to the network columns, where a maximum of four branches can join at a junction. The solution has therefore been sought in side-branched mesogens that lie in axial bundles joined at their ends by flexible "hinges". But for the tightly packed double framework, geometric models predicted that the side-chains should be very short. The true Plumber's nightmare reported here, using fluorescent dithienofluorenone rod-like mesogen, has been achieved with, indeed, no side chains at all, but with 6 flexible end-chains. Such molecules normally form columnar phases, but the key to converting a complex helical column-forming mesogen into a framework-forming one was the addition of just one methyl group to each pendant chain. A geometry-based explanation is given., (© 2024 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)

The sulfane sulfur pool, comprised of persulfide (RS-SH) and polysulfide (RS-S n H) derived from hydrogen sulfide (H 2 S), has emerged as a major player in redox biochemistry. Mitochondria, besides energy generation, serve as significant cellular redox hubs, mediate stress response and cellular health. However, the effects of endogenous mitochondrial sulfane sulfur (MSS) remain largely uncharacterized as compared with their cytosolic counterparts, cytosolic sulfane sulfur (CSS). To investigate this, we designed a novel artificial substrate for mitochondrial 3-mercaptopyruvate sulfurtransferase (3-MST), a key enzyme involved in MSS biosynthesis. Using cells expressing a mitochondrion-localized persulfide biosensor, we demonstrate this tool's ability to selectively enhance MSS. While H 2 S was previously known to suppress human immunodeficiency virus (HIV-1), we found that MSS profoundly affected the HIV-1 life cycle, mediating viral reactivation from latency. Additionally, we provide evidence for the role of the host's mitochondrial redox state, membrane potential, apoptosis, and respiration rates in managing HIV-1 latency and reactivation. Together, dynamic fluctuations in the MSS pool have a significant and possibly conflicting effect on HIV-1 viral latency. The precision tools developed herein allow for orthogonal generation of persulfide within both mitochondria and the cytosol and will be useful in interrogating disease biology., (© 2024 Wiley-VCH GmbH.)

Amino acids are a class of compounds with wide-ranging applications. The synthesis of amino acids from biomass-derived α-keto acids and ammonia is a sustainable way but the unstable primary imine intermediates (R-C=NH) easily form oligomers. Herein, targeting this problem, alkaline modified mesoporous silica was employed as a support for ruthenium (Ru/M-MCM-41), which could be used as a bifunctional catalyst in the reductive amination of α-keto acids to synthesize α-amino acids. The incorporation of Sr improved the dispersion of Ru nanoparticles and enhanced metal-support interactions via electron transfer from Sr to Ru, and the active Ru sites could efficiently hydrogenate primary imine intermediates to α-amino acids, thus prohibiting the formation of oligomers. Moreover, the Sr-dopant introduces base sites that could catalyze the hydrolysis of oligomers back to primary imine intermediates and finally hydrogenated to α-amino acids. As a result, >99 % yield of glycine was achieved from glyoxylic acid over Ru/Sr-MCM-41, which is nearly three times that achieved over Ru/MCM-41 (32.2 %)., (© 2024 Wiley-VCH GmbH.)

Electrical stimulation has been hotpot research and provoked extensive interest in a broad application such as wound closure, tissue injury repair, and nerve engineering. In particular, immense efforts have been dedicated to developing electrical microneedles, which demonstrate unique features in terms of controllable drug release, real-time monitoring, and therapy, thus greatly accelerating the process of wound healing. Here, a review of state-of-art research concerning electrical microneedles applied for wound treatment is presented. After a comprehensive analysis of the mechanisms of electrical stimulation on wound healing, the derived three types of electrical microneedles are clarified and summarized. Further, their applications in wound healing are highlighted. Finally, current perspectives and directions for the development of future electrical microneedles in improving wound healing are addressed., (© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)

Immunotherapy involving PDL1 degradation holds great potential in anti-tumor treatment. Optimal design of PDL1 degraders and subsequent efficient delivery into tumors are essential for expected efficacy, especially when abnormal tumor vasculature is considered. Herein, a nanodroplet-based novel drug delivery platform termed as NDs mTx (nanodroplet-based therapeutics) for ultrasound targeted delivery of PDL1 degrader is designed. Briefly, the shell of the NDs mTx is armed with RGD and mPD1 (a bioorthogonal PD1 mutant produced by genetic codon expansion technology can covalently bind PDL1), and the core is composed of perfluorohexane (PFH, C6F14). The RGD on the NDs mTx recognizes αvβ3 expressed by tumor vasculature, making NDs mTx accumulated in tumor practical and visible by low-frequency ultrasound (LFUS). In turn, inertial cavitation induced by LFUS facilitates mPD1 on the nanodroplet debris penetrating the tumor, where mPD1 covalently binds PDL1 and initiates a lysosomal degradation process. Through both in vitro and in vivo study, the superior performance of NDs mTx in degrading PDL1 and boosting anti-tumor immunity is confirmed. In conclusion, NDs mTx emerge as an alternative to existing PDL1 blockers in tumor immunotherapy., (© 2024 Wiley‐VCH GmbH.)

Exploring novel materials with intrinsic self-trapped excitons (STEs) is crucial for advancing optoelectronic technologies. In this study, 2D 3R-phase ZnIn 2 S 4 , featuring broken inversion symmetry , is introduced to investigate intrinsic STEs. This material exhibits a broadband photoluminescence (PL) emission with a full width at half maximum of 164 nm and a large Stokes shift of ≈0.6 eV, which arises from the distortion of [ZnS 4 ] 6- tetrahedral unit induced by the symmetry breaking and strong electron-phonon coupling. The photophysical properties of the STEs exhibit a high Huang-Rhys factor (15.0), rapid STEs formation time (166 fs), and extended STEs lifetime (1039 ps), as demonstrated by experimental evidence from temperature-dependent PL, Raman spectroscopy, and ultrafast absorption spectroscopy. Additionally, STE-induced photoconductive effect is elucidated, indicating that intrinsic STEs in 3R-ZnIn 2 S 4 can provide a synergistic effect that enhances absorption capacity, localization, and lifetime by capturing the self-trapped hole state. Consequently, the 2D 3R-ZnIn 2 S 4 photodetector exhibits remarkable broad-spectrum photosensitivity, including a photo-switching ratio of 11286, response times of less than 0.6 ms, responsivity of 15.2 A W -1 , detectivity of 1.02 × 10¹¹ Jones, and external quantum efficiency of 5032% under 375 nm light. These findings provide new ideas for exploring materials with intrinsic STEs to achieve novel high-performance photodetector applications., (© 2024 Wiley‐VCH GmbH.)

Intelligent wearable sensors based on MXenes hydrogels are rapidly advancing the frontier of personalized healthcare management. MXenes, a new class of transition metal carbon/nitride synthesized only a decade ago, have proved to be a promising candidate for soft sensors, advanced human-machine interfaces, and biomimicking systems due to their controllable and high electrical conductivity, as well as their unique mechanical properties as derived from their atomistically thin layered structure. In addition, MXenes' biocompatibility, hydrophilicity, and antifouling properties render them particularly suitable to synergize with hydrogels into a composite for mechanoelectrical functions. Nonetheless, while the use of MXene as a multifunctional surface or an electrical current collector such as an energy device electrode is prevalent, its incorporation into a gel system for the purpose of sensing is vastly less understood and formalized. This review provides a systematic exposition to the synthesis, property, and application of MXene hydrogels for intelligent wearable sensors. Specific challenges and opportunities on the synthesis of MXene hydrogels and their adoption in practical applications are explicitly analyzed and discussed to facilitate cross gemination across disciplines to advance the potential of MXene multifunctional sensing hydrogels., (© 2024 Wiley‐VCH GmbH.)

During the reaction process in lithium-sulfur batteries, Lewis acidic lithium polysulfides (LiPSs) affect ion distribution and overall electrolyte stability, degrading battery performance and product distribution (e.g., Li 2 S). Here, a microenvironment regulation strategy with optimized interface electronics and selective supramolecular channels, is proposed to enhance LiPS reaction kinetics through Lewis basic γ-cyclodextrin metal-organic framework (γ-CDMOF). To validate this concept, γ-CDMOF is rapidly synthesized on 3D graphene foam (GF) via a microwave-assisted method, resulting in a γ-CDMOF/GF cathode for high-performance Li-S batteries. A range of analytical techniques combined with density functional theory (DFT) calculations confirm that introducing a Lewis basic supramolecular microenvironment mitigates the LiPSs shuttle effect, enhances polysulfide capture, and improves sulfur redox conversion. Additionally, COMSOL simulations reveal that the γ-CDMOF framework and oxygen sites significantly reduce volumetric expansion stress during the LiPS solid-liquid phase transition. Impressively, the γ-CDMOF/GF cathode exhibits exceptional performance, including a high specific capacity (1253.01 mAh g⁻¹ at 0.1C), excellent rate performance (589.68 mAh g⁻¹ at 5C), and long cycle life (over 1200 cycles). This study introduces a new concept of supramolecular microenvironment regulation and interfacial interaction strategy, offering a unique approach for the development of multifunctional electrode materials., (© 2024 Wiley‐VCH GmbH.)

Biopolymer-based triboelectric nanogenerators (B-TENGs) represent an innovative fusion of eco-friendly, sustainable energy-harvesting technology with renewable and environmentally benign biopolymer material. This integration not only introduces novel pathways for advancing green energy solutions but also offers a critical approach to addressing contemporary environmental challenges and fostering sustainable progress. Over the past few years, B-TENGs have seen rapid and remarkable growth in the realm of biopolymers, device architecture, and their applications (e.g., implantable power source, electronic medicine, human anatomical and physiological movements monitoring sensors, etc.). In this review article, the promising developments in harnessing triboelectric biopolymers are encapsulated, enumerate their representative applications, evaluate the pros and cons of these biopolymers, highlight key challenges for future research, and offer strategic recommendations for innovating and realizing advanced B-TENGs., (© 2024 Wiley‐VCH GmbH.)

Postbiotics, defined as products or metabolic byproducts secreted by live bacteria or released after bacterial lysis, are emerging as promising therapeutic agents for metabolic dysfunction-associated steatotic liver disease (MASLD). This review explores the antiinflammatory and immunomodulatory properties of various postbiotics, including exopolysaccharides, lipoteichoic acid, short-chain fatty acids, hydrogen sulfide, polyamines, tryptophan derivatives, and polyphenol metabolites. These compounds have demonstrated potential in mitigating steatotic liver infiltration, reducing inflammation, and slowing fibrosis progression in preclinical studies. Notably, postbiotics exert their beneficial effects by modulating gut microbiota composition, enhancing intestinal barrier function, optimizing lipid metabolism, reducing hepatic inflammation and steatosis, and exhibiting hepatoprotective properties. However, translating these findings into clinical practice requires well-designed trials to validate efficacy and safety, standardize production and characterization, and explore personalized approaches and synergistic effects with other therapeutic modalities. Despite challenges, the unique biological properties of postbiotics, such as enhanced safety compared to probiotics, make them attractive candidates for developing novel nutritional interventions targeting the multifactorial pathogenesis of MASLD. Further research is needed to establish their clinical utility and potential to improve liver and systemic outcomes in this increasingly prevalent condition., (© 2024 The Author(s). Molecular Nutrition & Food Research published by Wiley‐VCH GmbH.)

The hard carbon (HC) anode materials demonstrate high capacity and excellent rate performance in lithium-ion batteries. However, HC anodes suffer from excessive loss of Li + ions during the formation of the solid electrolyte interphase (SEI) film, leading to poor cycling stability, which hinders their large-scale applications. Herein, a facile pre-lithiation strategy is proposed to achieve multi-functional precompensation of carbon nanofibers (CNFs) anodes. Both experimental and density functional theory (DFT) calculation results revealed that the strategy compensated for the loss of Li + ions and reacted with four structures of CNFs during pre-lithiation, including tiny graphite domains, CO-containing functional groups, defects, and micropores. Furthermore, the lithium in pre-lithiated carbon nanofibers (pCNFs) existed in various forms, consisting of LiC 24 and LiC 18 , Li─O─C, quasi-metallic lithium, and Li + ions. Moreover, the uniformly distributed lithium on the surface of pCNFs induced the formation of denser and more robust LiF/Li 2 CO 3 -rich SEI film, which promoted Li + ions transport. As a result, pCNFs showed more stable cycling performance (369.8 mAh g -1 , almost no decay for 1500 cycles). This work provides deeper insight into chemical pre-lithiation and offers a simple and mild strategy for highly stable batteries., (© 2024 Wiley‐VCH GmbH.)

The world faces a trade-off between water availability and food supply, as agricultural irrigation consumes the largest freshwater globally. Inspired by inherent water transport channels in plants, a cost-effective welding pollen-based solar evaporator (PSE) is developed to obtain clean water from seawater desalination. Based on the convex and folded surface structure of natural pollen (Helianthus annuus) and the porous structure of welding pollen evaporator interconnection, the PSE reveals an efficient evaporation rate of 1.86 kg m -2 h -1 under one-sun illumination and further exhibits excellent cycling performance for 10 cycles tested in 7.0 wt.% saline water without salt accumulation. In addition, PSE has superior mechanical stability (3.44 MPa) and remains stable after being immersed in pH 1 and 14 solutions for 24 h without sacrificing mechanical properties. Importantly, the work has demonstrated the success of the freshwater collected from the evaporation process, which can effectively facilitate the cultivation of lettuce, rice, and wheat. These findings highlight the practical application of pollen as a low-cost, eco-friendly natural resource in interfacial solar evaporation. Furthermore, they inspire addressing current global water scarcity and promoting sustainable agriculture., (© 2024 Wiley‐VCH GmbH.)

Chemical reactions underpin biological processes, and imbalances in critical biochemical pathways within organisms can lead to the onset of severe diseases. Within this context, the emerging field of "Nanocatalytic Medicine" leverages nanomaterials as catalysts to modulate fundamental chemical reactions specific to the microenvironments of diseases. This approach is designed to facilitate the targeted synthesis and localized accumulation of therapeutic agents, thus enhancing treatment efficacy and precision while simultaneously reducing systemic side effects. The effectiveness of these nanocatalytic strategies critically hinges on a profound understanding of chemical kinetics and the intricate interplay of reactions within particular pathological microenvironments to ensure targeted and effective catalytic actions. This review methodically explores in situ catalytic reactions and their associated biomaterials, emphasizing regulatory strategies that control therapeutic responses. Furthermore, the discussion encapsulates the crucial elements-reactants, catalysts, and reaction conditions/environments-necessary for optimizing the thermodynamics and kinetics of these reactions, while rigorously addressing both the biochemical and biophysical dimensions of the disease microenvironments to enhance therapeutic outcomes. It seeks to clarify the mechanisms underpinning catalytic biomaterials and evaluate their potential to revolutionize treatment strategies across various pathological conditions., (© 2024 Wiley‐VCH GmbH.)

The electrocatalytic oxidation of 5-hydroxymethylfurfural (HMF) provides a feasible approach for the efficient utilization of biomass. Defect regulation is an effective strategy in the field of biomass upgrading to enhance the adsorption capacity of reactants and thus increase the activity. However, how to select appropriate strategies to regulate the over-enrichment of reactants induced by excessive oxygen vacancy is still a huge challenge. In this work, the defect-filling strategy to design and construct an element-filled oxygen vacancy site layered double hydroxide (S─Ov─LDH) is adopted, which achieves a significant reduction in the electrolysis potential of biomass platform molecule HMF oxidation reaction and a significant increase in current density. Physical characterizations, electrochemical measurements, and theoretical calculations prove that the formation of metal─S bond in the second shell effectively regulates the electronic structure of the material, thus weakening the over-strong adsorption of HMF and OH - induced by excessive oxygen vacancy, promoting the formation of high-valence Co 3+ during the reaction, and forming new adsorption sites. This work discusses the catalytic enhancement mechanism of defect filling in detail, fills the gap of defect filling in the field of biomass upgrading, and provides favorable guidance for the further development of defect regulation strategies., (© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)

Rechargeable magnesium batteries (RMBs) have the potential to provide a sustainable and long-term solution for large-scale energy storage due to high theoretical capacity of magnesium (Mg) metal as an anode, its competitive redox potential (Mg/Mg 2+ :-2.37 V vs. SHE) and high natural abundance. To develop viable magnesium batteries with high energy density, the electrolytes must meet a range of requirements: high ionic conductivity, wide electrochemical potential window, chemical compatibility with electrode materials and other battery components, favourable electrode-electrolyte interfacial properties and cost-effective synthesis. In recent years, significant progress in electrolyte development has been made. Herein, a comprehensive overview of these advancements is presented. Beginning with the early developments, we particularly focus on the chemical aspects of the electrolytes and their correlations with electrochemical properties. We also highlight the design of new anions for practical electrolytes, the use of electrolyte additives to optimize anode-electrolyte interfaces and the progress in polymer electrolytes., (© 2024 The Author(s). Chemistry - A European Journal published by Wiley-VCH GmbH.)

Organic luminescence materials makes the molecule more enthusiastic in wide variety of applications. The luminescent organic materials are in a attraction of the researchers, and the Aggregation-Induced Emission (AIE) is attributed to the occurrence that particular chromophores (typically fluorophores) display very low or nearly no emission in the monomolecular soluble state but become highly emissive when forming aggregates in solution or in solid state. This phenomenon is relatively abnormal when compared with many other traditional fluorophores. AIE research suppresses aggregation-caused quenching (ACQ). Nevertheless, the carbon dots (CDs) and quantum dots have shown to have tyical florescence properties, therefore, recent years many researchers have also attracted for their developments. The CDs, luminescent, and AIE materials are not only used in biomedical applications and organic light-emitting diodes but also in sensing, self-assembly, and other areas. One should introduce promising material to a designed framework that exhibits AIE characteristics to ensure moral results in AIE. Amongest, AIE-active tetraphenylethylene (TPE) is attractive fluorophores due to its easy synthesis strategy. This review article discusses the synthesis properties of TPE, CDs, and luminescent materials with a broad range of applications. We have outlined linear, branched-shaped supramolecular, and hybrid macromolecules due to its potential in the future., (© 2024 Wiley-VCH GmbH.)

Manipulating intracellular biological processes and organelles has emerged as a pivotal strategy to influence cellular physiological functions. Mitochondria, recognized as the powerhouse of cells, play a crucial role in tumorigenesis and progression. Inspired by the Nature's tyrosinase-catalyzed melanin formation within melanoma cells, here an approach is developed using a polysaccharide dually-functionalized with tyrosine and triphenylphosphine (TPP) for targeted mitochondria cross-linking in melanoma cells. This technique intricately weaves melanin nets within the cells, serving as a tether for the mitochondria and effectively decelerating tumor metabolism through nanoparticle-net transformation. Tyrosinase acts as the "needle", while the functionalized polysaccharide serves as the "string" successfully constructing nets within the cell. Furthermore, the tyrosinase-catalyzed cross-linking of tyrosine not only facilitates the production of artificial melanin but also enhances the photothermal conversion efficiency of melanoma cells, leading to decrease of the tumor growth. This study unveils a non-drug method for regulating organelle physiological activity and introduces photothermal treatment. This work not only sheds light on the manipulation of cellular functions but also holds promise for advancing cancer therapeutic strategies., (© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.)

As a true 1D system, group-VIA tellurium (Te) is composed of van der Waals bonded molecular chains within a triangular crystal lattice. This unique crystal structure endows Te with many intriguing properties, including electronic, optoelectronic, thermoelectric, piezoelectric, chirality, and topological properties. In addition, the bandgap of Te exhibits thickness dependence, ranging from 0.31 eV in bulk to 1.04 eV in the monolayer limit. These diverse properties make Te suitable for a wide range of applications, addressing both established and emerging challenges. This review begins with an elaboration of the crystal structures and fundamental properties of Te, followed by a detailed discussion of its various synthesis methods, which primarily include solution phase, and chemical and physical vapor deposition technologies. These methods form the foundation for designing Te-centered devices. Then the device applications enabled by Te nanostructures are introduced, with an emphasis on electronics, optoelectronics, sensors, and large-scale circuits. Additionally, performance optimization strategies are discussed for Te-based field-effect transistors. Finally, insights into future research directions and the challenges that lie ahead in this field are shared., (© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.)

Metamaterials are emerging as an unconventional platform to perform computing abstractions in physical systems by processing environmental stimuli into information. While computation functions have been demonstrated in mechanical systems, they rely on compliant mechanisms to achieve predefined states, which impose inherent design restrictions that limit their miniaturization, deployment, reconfigurability, and functionality. Here, a metamaterial system is described based on responsive magnetoactive Janus particle (MAJP) swarms with multiple programmable functions. MAJPs are designed with tunable structure and properties in mind, that is, encoded swarming behavior and fully reversible switching mechanisms, to enable programmable dynamic display, non-volatile and semi-volatile memory, Boolean logic, and information encryption functions in soft, wearable devices. MAJPs and their unique swarming behavior open new functions for the design of multifunctional and reconfigurable display devices, and constitute a promising building block to develop the next generation of soft physical computing devices, with growing applications in security, defense, anti-counterfeiting, camouflage, soft robotics, and human-robot interaction., (© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.)

Lithium-ion batteries using quasi-solid gel electrolytes (QSEs) have gained increasing interest due to their enhanced safety features. However, their commercial viability is hindered by low ionic conductivity and poor solid-solid contact interfaces. In this study, a QSE synthesized by in situ polymerizing methyl methacrylate (MMA) in 1,2-dimethoxyethane (DME)-based electrolyte is introduced, which exhibits remarkable performance in high-loading graphite||LiNi 0.8 Co 0.1 Mn 0.1 O 2 (NCM811) pouch cells. Owing to the unique solvent-lacking solvation structure, the graphite exfoliation caused by the well-known solvent co-intercalation is prohibited, and this unprecedented phenomenon is found to be universal for other graphite-unfriendly solvents. The high ionic conductivity and great interfacial contact provided by DME enable the quasi-solid graphite||NCM811 pouch cell to demonstrate superior C-rate capability even at a high cathode mass loading (17.5 mg cm -2 ), surpassing liquid carbonate electrolyte cells. Meanwhile, the optimized QSE based on carbonates exhibits excellent cycle life (92.4% capacity retention after 1700 cycles at 0.5C/0.5C) and reliable safety under harsh conditions. It also outperforms liquid electrolytes in other high-energy-density batteries with larger volume change. These findings elucidate the polymer's pivotal role in QSEs, offering new insights for advancing quasi-solid-state battery commercialization., (© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.)

Proteins have emerged as promising therapeutics in oncology due to their great specificity. Many treatment strategies are developed based on protein biologics, such as immunotherapy, starvation therapy, and pro-apoptosis therapy, while some protein biologics have entered the clinics. However, clinical translation is severely impeded by instability, short circulation time, poor transmembrane transportation, and immunogenicity. Micro- and nano-particles-based drug delivery platforms are designed to solve those problems and enhance protein therapeutic efficacy. This review first summarizes the different types of therapeutic proteins in clinical and research stages, highlighting their administration limitations. Next, various types of micro- and nano-particles are described to demonstrate how they can overcome those limitations. The potential of micro- and nano-particles are then explored to enhance the therapeutic efficacy of proteins by combinational therapies. Finally, the challenges and future directions of protein biologics carriers are discussed for optimized protein delivery., (© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.)

Glioblastoma is one of the most aggressive and treatment-resistant forms of primary brain cancer, posing significant challenges in effective therapy. This study aimed to enhance the effectiveness of glioblastoma therapy by developing a unique nanomedicine composed of Pluronic F127-complexed PEGylated poly(glutamic acid)-cisplatin (PLG-PEG/PF127-CDDP). PLG-PEG/PF127-CDDP demonstrated an optimal size of 133.97 ± 12.60 nm, facilitating efficient cell uptake by GL261 glioma cells. In vitro studies showed significant cytotoxicity against glioma cells with a half-maximal (50%) inhibitory concentration (IC50) of 12.61 µg mL -1 at 48 h and a 72.53% ± 1.89% reduction in cell invasion. Furthermore, PLG-PEG/PF127-CDDP prolonged the circulation half-life of cisplatin to 9.75 h in vivo, leading to a more than 50% reduction in tumor size on day 16 post-treatment initiation in a murine model of glioma. The treatment significantly elevated lactate levels in GL261 cells, indicating enhanced metabolic disruption. Therefore, PLG-PEG/PF127-CDDP offers a promising approach for glioblastoma therapy due to its effects on improving drug delivery efficiency, therapeutic outcomes, and safety while minimizing systemic side effects. This work underscores the potential of polymer-based nanomedicines in overcoming the challenges of treating brain tumors, paving the way for future clinical applications., (© 2024 Wiley‐VCH GmbH.)

Aminopeptidases are exopeptidases that catalyze the cleavage of amino acid residues from the N-terminal fragment of protein or peptide substrates. Owing to their function, they play important roles in protein maturation, signal transduction, cell-cycle control, and various disease mechanisms, notably in cancer pathology. To gain better insights into their function, molecular imaging assisted by fluorescence and bio/chemiluminescence probes has become an indispensable method to their superiorities, including excellent sensitivity, selectivity, and real-time and noninvasive imaging. Numerous efforts are made to develop activatable probes that can effectively enhance efficiency and accuracy as well as minimize the side effects. This review is classified according to the type of aminopeptidases, summarizing some recent works on the design, work mechanism, and sensing, imaging, and theranostic performance of their activatable probe. Finally, the current challenges are outlined in developing activatable probes for aminopeptidases and provide possible solutions for future advancements., (© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.)

Sonodynamic therapy can trigger immunogenic cell death to augment immunotherapy, benefiting from its superior spatiotemporal selectivity and non-invasiveness. However, the practical applications of sonosensitizers are hindered by their low efficacy in killing cancer cells and activating immune responses. Here, two US Food and Drug Administration-approved drug ligands (ferricyanide and nitroprusside) and two types of metals (copper/iron) are selected to construct a bimetal-biligand framework (Cu[PBA-NO]). Through elaborate regulation of multiple metal/ligand coordination, the systemically administered Cu[PBA-NO] nanoagent shows sono-catalytic and NO release ability under ultrasound irradiation, which can be used for effective sono-immunotherapy. Moreover, Cu[PBA-NO] can downregulate intracellular glutathione levels that would destroy intracellular redox homeostasis and facilitate reactive oxygen species accumulation. The released tumor-associated antigens subsequently facilitate dendritic cell maturation within the tumor-draining lymph node, effectively initiating a T cell-mediated immune response and thereby bolstering the capacity to identify and combat cancer cells. This study paves a new avenue for the efficient cancer sono-immunotherapy., (© 2024 Wiley‐VCH GmbH.)

Environmental-friendless and high-performance thermoelectrics play a significant role in exploring sustainable clean energy. Among them, AgSbTe 2 thermoelectrics, benefiting from the disorder in the cation sublattice and interface scattering from secondary phases of Ag 2 Te and Sb 2 Te 3 , exhibit low thermal conductivity and a maximum figure-of-merit ZT of 2.6 at 573 K via optimizing electrical properties and addressing phase transition issues. Therefore, AgSbTe 2 shows considerable potential as a promising medium-temperature thermoelectric material. Additionally, with the increasing demands for device integration and portability in the information age, the research on flexible and wearable AgSbTe 2 thermoelectrics aligns with contemporary development needs, leading to a growing number of research findings. This work provides a detailed and timely review of AgSbTe 2 -based thermoelectrics from materials to devices. Principles and performance optimization strategies are highlighted for the thermoelectric performance enhancement in AgSbTe 2 . The current challenges and future research directions of AgSbTe 2 -based thermoelectrics are pointed out. This review will guide the development of high-performance AgSbTe 2 -based thermoelectrics for practical applications., (© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.)

Solid-state polymer lithium metal batteries are an important strategy for achieving high safety and high energy density. However, the issue of Li dendrites and inherent inferior interface greatly restricts practical application. Herein, this study introduces tris(2,2,2-trifluoroethyl)phosphate solvent with moderate solvation ability, which can not only complex with Li + to promote the in-situ ring-opening polymerization of 1,3-dioxolane (DOL), but also build solvated structure models to explore the effect of different solvation structures in the polymer electrolyte. Thereinto, it is dominated by the contact ion pair solvated structure with pDOL chain segments forming less lithium bonds, exhibiting faster kinetic process and constructing a robust anion-derived inorganic-rich interphase, which significantly improves the utilization rate of active Li and the high-voltage resistance of pDOL. As a result, it exhibits stable cycling at ultra-high areal capacity of 20 mAh cm -2 in half cells, and an ultra-long lifetime of over 2000 h in symmetric cells can be realized. Furthermore, matched with LiNi 0.9 Co 0.05 Mn 0.05 O 2 cathode, the capacity retention after 60 cycles is as high as 96.8% at N/P value of 3.33. Remarkably, 0.7 Ah Li||LiNi 0.9 Co 0.05 Mn 0.05 O 2 pouch cell with an energy density of 461 Wh kg -1 can be stably cycled for five cycles at 100% depth of discharge., (© 2024 Wiley‐VCH GmbH.)

Photo-assisted Zn-air batteries can accelerate the kinetics of oxygen reduction and oxygen evolution reactions (ORR/OER); however, challenges such as rapid charge carrier recombination and continuous electrolyte evaporation remain. Herein, for the first time, piezoelectric catalysis is introduced in a photo-assisted Zn-air battery to improve carrier separation capability and accelerate the ORR/OER kinetics of the photoelectric cathode. The designed microhelical catalyst exploits simple harmonic vibrations to regenerate the built-in electric field continuously. Specifically, in the presence of the low-frequency kinetic energy that occurs during water flow, the piezoelectric-photocoupling catalyst of poly(vinylidene fluoride-co-trifluoroethylene)@ferric oxide(Fe@P(V-T)) is periodically deformed, generating a constant reconfiguration of the built-in electric field that separates photogenerated electrons and holes continuously. Further, on exposure to microvibrations, the gap between the charge and discharge potentials of the Fe@P(V-T)-based photo-assisted Zn-air battery is reduced by 1.7 times compared to that without piezoelectric assistance, indicating that piezoelectric catalysis is highly effective for enhancing photocatalytic efficiency. This study provides a thorough understanding of coupling piezoelectric polarization and photo-assisted strategy in the field of energy storage and opens a fresh perspective for the investigation of multi-field coupling-assisted Zn-air batteries., (© 2024 Wiley‐VCH GmbH.)

As cytoplasmic protein complexes that are pivotal for innate immunity, inflammasomes act primarily through the detection of pathogen- or danger-associated molecular patterns. Nucleotide oligomerisation domain-like receptor family and caspase activation recruitment domain-containing protein 4 (NLRC4) inflammasomes identify and eliminate intracellular pathogens, a process contingent on the ligand-recognition capabilities of neuronal apoptosis inhibitory proteins (NAIPs). Upon detection of specific molecules indicative of intracellular infection, NAIPs discern distinct pathogenic components and subsequently transmit signals to NLRC4, thus initiating their activation and triggering an inflammatory response. However, the mechanisms underlying NLRC4 inflammasome remain unclear. In this study, we elucidated the critical role of ATG16L2 in activating the NLRC4 inflammasome. ATG16L2-deficient macrophages exhibited reduced NLRC4 inflammasome activation, characterised by decreased oligomerisation of apoptosis-associated speck-like protein containing a CARD and attenuated cleavage of Pro-caspase-1, Pro-IL-1β and gasdermin D. Co-immunoprecipitation assays revealed an interaction between ATG16L2 and NAIPs. Furthermore, ATG16L2 enhanced the association between NAIPs and NLRC4 by binding to NAIPs. For ATG16L2-knockout mice infected with Salmonella typhimurium, pathogen clearance and survival rates markedly decreased. Collectively, our findings suggest that ATG16L2 is a significant modulator of the innate immune system, influencing the activity of the NLRC4 inflammasome and the host's defensive response to intracellular pathogens., (© 2024 The Author(s). European Journal of Immunology published by Wiley‐VCH GmbH.)

A great challenge in the commercialization process of layered Ni-rich cathode material LiNi x Co y Mn 1-x-y O 2 (NCM, x ≥ 80%) for lithium-ion batteries is the surface instability, which is exacerbated by the increase in nickel content. The high surface alkalinity and unavoidable cathode/electrolyte interface side reactions result in significant decrease for the capacity of NCM material. Surface coating and doping are common and effective ways to improve the electrochemical performance of Ni-rich cathode material. In this study, an in situ reaction is induced on the surface of secondary particles of NCM material to construct a stable lithium sulfate coating, while achieving sulfur doping in the near surface region. The synergistic modification of lithium sulfate coating and lattice sulfur doping significantly reduced the content of harmful residual lithium compounds (RLCs) on the surface of NCM material, suppressed the side reactions between the cathode material surface and electrolyte and the degradation of surface structure of the NCM material, effectively improved the rate capability and cycling stability of the NCM material., (© 2024 Wiley‐VCH GmbH.)

Synergistic therapy has become the major therapeutic method for malignant tumors in clinical. Photodynamic therapy (PDT) and radiotherapy (RT) always combine together because of their identical anti-tumor mechanisms, that is reactive oxygen species are generated by the use of radiosensitizers after irradiation by X-ray to efficiently kill cancer cells, PDT also follows similar mechanism. Full exposure of energy-absorbing species in nanomaterials to X-ray or near-infrared light irradiation makes the energy interchange between nanomaterials and surrounding H 2 O or dissolved oxygen easier, however, it remains challenging. Herein, an ultrathin two-dimensional (2D) nanosheet (NS) is developed, Bi 2 O 2 CO 3 , doped with lanthanide ions to give out upconversion luminescence, where the high Z elements Bi, Yb, and Er promote the radio-sensitizing effect. To the surprise, lanthanide activator ions gave out completely different luminescence properties compared with traditional upconversion nanoparticles. Less dopant of Er ions in nanosheets lattice resulted in brighter red emission, which provides more efficient PDT. Under RT/PDT combined treatment, NS shows a good tumor growth-inhibiting effect. In addition, synergistic therapy requires lower radiation dose than conventional radiotherapy and lower light power than single photodynamic therapy, thus greatly reducing radiation damage caused by RT and thermal damage caused by PDT., (© 2024 Wiley‐VCH GmbH.)

Microbial cellulose stands out for its exceptional characteristics in the form of biofilms formed by highly interlocked fibrils, namely, bacterial nanocellulose (BNC). Concurrently, bio-based aerogels are finding uses in innovative materials owing to their lightweight, high surface area, physical, mechanical, and thermal properties. In particular, bio-based aerogels based on BNC offer significant opportunities as alternatives to synthetic or mineral counterparts. BNC aerogels are proposed for diverse applications, ranging from sensors to medical devices, as well as thermal and electroactive systems. Due to the fibrous nanostructure of BNC and the micro-porosity of BNC aerogels, these materials enable the creation of tailored and specialized designs. Herein, a comprehensive review of BNC-based aerogels, their attributes, hierarchical, and multiscale features are provided. Their potential across various disciplines is highlighted, emphasizing their biocompatibility and suitability for physical and chemical modification. BNC aerogels are shown as feasible options to advance material science and foster sustainable solutions through biotechnology., (© 2024 The Author(s). Small published by Wiley‐VCH GmbH.)

Traditional ethylene carbonate (EC)-based electrolytes constrain the applications of silicon carbon (Si-C) anodes under fast-charging and low-temperature conditions due to sluggish Li + migration kinetics and unstable solid electrolyte interphase (SEI). Herein, inspired by the efficient water purification and soil stabilization of aquatic plants, a stable SEI with a 3D desolvation interface is designed with gel polymer electrolyte (GPE), accelerating Li + desolvation and migration at the interface and within stable SEI. As demonstrated by theoretical simulations and experiment results, the resulting poly(1,3-dioxolane) (PDOL), prepared by in situ ring-opening polymerization of 1,3-dioxolane (DOL), creates a 3D desolvation area, improving the Li + desolvation at the interface and yielding an amorphous GPE with a high Li + ionic conductivity (5.73 mS cm -1 ). Furthermore, more anions participate in the solvated structure, forming an anion-derived stable SEI and improving Li + transport through SEI. Consequently, the Si-C anode achieves excellent rate performance with GPE at room temperature (RT) and low temperature (-40 °C). The pouch full cell coupled with LiFePO 4 cathode obtains 97.42 mAh g -1 after 500 cycles at 5 C/5 C. This innovatively designed 3D desolvation interface and SEI represent significant breakthroughs for developing fast-charging and low-temperature batteries., (© 2024 Wiley‐VCH GmbH.)

Graphitic carbon nitride (g-C 3 N 4 ) is a prominent photocatalyst that has attracted substantial interest in the field of photocatalytic environmental remediation due to the low cost of fabrication, robust chemical structure, adaptable and tunable energy bandgaps, superior photoelectrochemical properties, cost-effective feedstocks, and distinctive framework. Nonetheless, the practical application of bulk g-C 3 N 4 in the photocatalysis field is limited by the fast recombination of photogenerated e - -h + pairs, insufficient surface-active sites, and restricted redox capacity. Consequently, a great deal of research has been devoted to solving these scientific challenges for large-scale applications. This review concisely presents the latest advancements in g-C 3 N 4 -based photocatalyst modification strategies, and offers a comprehensive analysis of the benefits and preparation techniques for each strategy. It aims to articulate the complex relationship between theory, microstructure, and activities of g-C 3 N 4 -based photocatalysts for atmospheric protection. Finally, both the challenges and opportunities for the development of g-C 3 N 4 -based photocatalysts are highlighted. It is highly believed that this special review will provide new insight into the synthesis, modification, and broadening of g-C 3 N 4 -based photocatalysts for atmospheric protection., (© 2024 Wiley‐VCH GmbH.)

Electrochemical upcycling of nitrate and polyester plastic into valuable products is an ideal solution to realize the resource utilization. Here, the co-production of ammonia (NH 3 ) and glycolic acid (GA) via electrochemical upcycling of nitrate and polyethylene terephthalate (PET) plastics over mesoporous Pd 3 Au film on Ni foam (mPd 3 Au/NF), which is synthesized by micelle-assisted replacement method, is proposed. The mPd 3 Au/NF with well-developed mesoporous structure provides abundant active sites and facilitated transfer channels and strong electronic effect. As such, the mPd 3 Au/NF exhibits high Faraday efficiencies of 97.28% and 95.32% at 0.9 V for the formation of NH 3 and GA, respectively. Theoretical results indicate that the synergistic effect of Pd and Au can optimize adsorption energy of key intermediates *NOH and *OCH 2 -CH 2 OH on active sites and increase bond energy of C─C band, thereby improving the activity and selectivity for the formation of NH 3 and GA. This work proposes a promising strategy for the simultaneous conversation of nitrate and PET plastic into high-value NH 3 and GA., (© 2024 Wiley‐VCH GmbH.)

The high-energy (H 2 dabco)[NH 4 (ClO 4 ) 3 ] (DAP-4) with excellent energetic performance attracts wide attention from researchers. The investigation of its interaction with the Aluminum (Al) is of great importance. However, the higher ignition threshold of DAP-4 and the dense oxide layer (Al 2 O 3 ) of Al severely limit the energy release efficiency of Al/DAP-4. In this study, a new idea to is first proposed to improve and adjust the thermal decomposition and combustion performance of Al/DAP-4 by constructing a highly dispersed iron (Fe) nanoparticle interfacial layer. It acts as a gradient catalyst to promote the thermal decomposition and combustion of DAP-4 and Al, and it also act as an oxygen transport channel to promote the contact and reaction of oxidizing gases with the internal reactive Al powder. It reduces the thermal decomposition temperature of Al@Fe-3/DAP-4 from 386.30 °C (Al/DAP-4) to 349.48 °C and leads to the vigorous combustion. Theoretical calculations show that Fe nanoparticle interfacial layer can facilitate the transport of oxygen through the established oxygen transport channels, and it can also significantly improve the energetic properties of Al@Fe-3/DAP-4 composites. In conclusion, the new approach is proposed to improve the performance of metal fuel/oxidizer composites by constructing interfacial layers, which is expected to promote their practical applications., (© 2024 Wiley‐VCH GmbH.)

Herein, a three-armed amphiphilic metallacycle-cored star supramolecular polymer (Por-MOM-PDMAEMA) has been designed and synthesized via highly efficient post-assembly polymerization. This star polymer is further self-assembled into nanoparticles of different sizes depending upon the experimental conditions. The gas-controlled morphology transformation and tunable antibacterial activities of Por-MOM-PDMAEMAis systematically investigated and compared with metallacycle (MOM). The superior antibacterial activity of Por-MOM-PDMAEMA against multidrug-resistant P. aeruginosa implies that the presence of photodynamic photosensitizer (Por) and cationic polymer chain will significantly enhance antibactericidal activity, which is mainly attributed to the synergistic effect of photosensitizer and polymer chain linked in one metallacycle core. By leveraging the unique properties of metallacycle and their dynamic response to gaseous stimuli, the antibacterial properties of the Por-MOM-PDMAEMA can be finely tuned in response to gas triggers., (© 2024 Wiley‐VCH GmbH.)

Transition metal dichalcogenide TiSe 2 exhibits a superconducting dome within a low pressure range of 2-4 GPa, which peaks with the maximal transition temperature T c of ≈1.8 K. Here it is reported that applying high pressure induces a new superconducting state in TiSe 2 , which starts at ≈16 GPa with a substantially higher T c that reaches 5.6 K at ≈21.5 GPa with no sign of decline. Combining high-throughput first-principles structure search, X-ray diffraction, and Raman spectroscopy measurements up to 30 GPa, It is found that TiSe 2 undergoes a first-order structural transition from the 1T phase under ambient pressure to a new 4O phase under high pressure. Comparative ab initio calculations reveal that while the conventional phonon-mediated pairing mechanism may account for the superconductivity observed in 1T-TiSe 2 under low pressure, the electron-phonon coupling of 4O-TiSe 2 is too weak to induce a superconducting state whose transition temperature is as high as 5.6 K under high pressure. The new superconducting state found in pressurized TiSe 2 requires further study on its underlying mechanism., (© 2024 Wiley‐VCH GmbH.)

In practical applications, fluorescent perovskite quantum dots (PQDs) must exhibit high efficiency, stability, and processibility. So far, it remains a challenge to synthesize PQDs with stable dispersibility in tailorable monomers both before and after photocuring. In this work, a novel strategy of UV-induced two-step thiol-ene "click chemistry" is proposed to prepare PQDs with these attributes. The first step aims to epitaxially grow a shell around the PQD core to ensure stable dispersibility in a thiol-ene monomer solution. The second step is to achieve stable dispersibility in the photocured thiol-ene matrixes for multiform manufacturing processes. The tailorable PQDs (T-PQDs) not only have the highest photoluminescence quantum yield (PLQY) to ≈100% for green emission and over 96% for red emission, but also exhibit remarkable stability under severe conditions, including "double 85" aging, water exposure, and mechanical stress. Moreover, their exceptional processability allows for various processing techniques, including slot-die coating, inkjet printing, direct-laser writing, UV-light 3D printing, nanoimprinting, and spin coating. The high efficiency and stability of T-PQDs facilitate their multiform manufacturing for a wide range of applications., (© 2024 Wiley‐VCH GmbH.)

Miniaturized computational spectrometers have emerged as a promising strategy for miniaturized spectrometers, which breaks the compromise between footprint and performance in traditional miniaturized spectrometers by introducing computational resources. They have attracted widespread attention and a variety of materials, optical structures, and photodetectors are adopted to fabricate computational spectrometers with the cooperation of reconstruction algorithms. Here, a comprehensive review of miniaturized computational spectrometers, focusing on two crucial components: spectral encoding and reconstruction algorithms are provided. Principles, features, and recent progress of spectral encoding strategies are summarized in detail, including space-modulated, time-modulated, and light-source spectral encoding. The reconstruction algorithms are classified into traditional and deep learning algorithms, and they are carefully analyzed based on the mathematical models required for spectral reconstruction. Drawing from the analysis of the two components, cooperations between them are considered, figures of merits for miniaturized computational spectrometers are highlighted, optimization strategies for improving their performance are outlined, and considerations in operating these systems are provided. The application of miniaturized computational spectrometers to achieve hyperspectral imaging is also discussed. Finally, the insights into the potential future applications and developments of computational spectrometers are provided., (© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)

Structural battery integrated composites (SBICs) combining outstanding strength and heat resistance are highly desirable candidates for next generation high speed aircraft. Here, a novel high-temperature-resistant bi-continuous electrolyte based on phthalonitrile resin is presented, allowing the construction of SBICs capable of stable operation across a wide temperature range. Excellent mechanical strength and high ionic conductivity can coexist in a bi-continuous structure electrolyte (PL 50 ) where the phthalonitrile resin serves as the matrix phase and the ionic liquid electrolyte serves as the conductive phase. Benefiting from the thermal stability of the phthalonitrile resin, SBICs assembled with a PL 50 bi-continuous electrolyte deliver excellent mechanical performance even at temperatures exceeding 200 °C, with a flexural strength of 299 MPa and a flexural modulus of 31.8 GPa. Additionally, with an increase in operating temperature, PL 50 @SBICs demonstrated enhanced rate performance while maintaining good cycling stability. The demonstration of resisting mechanical abuse at high temperatures and flame retardance further suggests the promise of SBICs with PL 50 bi-continuous electrolytes operating under extreme conditions., (© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)

The discovery of nanoscale ferroelectricity in hafnia (HfO 2 ) has paved the way for next generation high-density, non-volatile devices. Although the surface conditions of nanoscale HfO 2 present one of the fundamental mechanism origins, the impact of external environment on HfO 2 ferroelectricity remains unknown. In this study, the deleterious effect of ambient moisture is examined on the stability of ferroelectricity using Hf 0.5 Zr 0.5 O 2 (HZO) films as a model system. It is found that the development of an intrinsic electric field due to the adsorption of atmospheric water molecules onto the film's surface significantly impairs the properties of domain retention and polarization stability. Nonetheless, vacuum heating efficiently counteracts the adverse effects of water adsorption, which restores the symmetric electrical characteristics and polarization stability. This work furnishes a novel perspective on previous extensive studies, demonstrating significant impact of surface water on HfO 2 -based ferroelectrics, and establishes the design paradigm for the future evolution of HfO 2 -based multifunctional electronic devices., (© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)

Cancer nanomedicine has emerged as a promising approach to overcome the limitations of conventional cancer therapies, offering enhanced efficacy and safety in cancer management. However, the inherent heterogeneity of tumors presents increasing challenges for the application of cancer nanomedicine in both diagnosis and treatment. This heterogeneity necessitates the integration of advanced and high-throughput analytical techniques to tailor nanomedicine strategies to individual tumor profiles. Omics technologies, encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics, and more, provide unparalleled insights into the molecular and cellular mechanisms underlying cancer. By dissecting tumor heterogeneity across multiple levels, these technologies offer robust support for the development of personalized and precise cancer nanomedicine strategies. In this review, the principles, techniques, and applications of key omics technologies are summarized. Especially, the synergistic integration of omics and nanomedicine in cancer therapy is explored, focusing on enhanced diagnostic accuracy, optimized therapeutic strategies and the assessment of nanomedicine-mediated biological responses. Moreover, this review addresses current challenges and outlines future directions in the field of omics-enhanced nanomedicine. By offering valuable insights and guidance, this review aims to advance the integration of omics with nanomedicine, ultimately driving improved diagnostic and therapeutic strategies for cancer., (© 2024 Wiley‐VCH GmbH.)

Metal-organic frameworks (MOFs), constructed by inorganic secondary building units with organic linkers via reticular chemistry, inherently suffer from poor solution processability due to their insoluble nature, resulting from their extensive crystalline networks and structural rigidity. The ubiquitous occurrence of precipitation and agglomeration of MOFs upon formation poses a significant obstacle to the scale-up production of MOF-based monolith, aerogels, membranes, and electronic devices, thus restricting their practical applications in various scenarios. To address the previously mentioned challenge, significant strides have been achieved over the past decade in the development of various strategies aimed at preparing solution-processable MOF systems. In this review, the latest advance in the synthetic strategies for the construction of solution-processable MOFs, including direct dispersion in ionic liquids, surface modification, controllable calcination, and bottom-up synthesis, is comprehensively summarized. The respective advantages and disadvantages of each method are discussed. Additionally, the intriguing applications of solution-processable MOF systems in the fields of liquid adsorbent, molecular capture, sensing, and separation are systematically discussed. Finally, the challenges and opportunities about the continued advancement of solution-processable MOFs and their potential applications are outlooked., (© 2024 Wiley‐VCH GmbH.)

Lead halide perovskite solar cells (PSCs) have demonstrated power conversion efficiencies comparable to silicon-based solar cells, yet their instability under environmental stressors, such as humidity, heat, and light, remains a significant barrier to commercialization. A primary cause of this instability is the uncoordinated lead ions (Pb 2+ ), which accelerates the degradation of PSCs and pose environmental concerns due to potential lead leakage. Recently, the introduction of ligands into PSCs has shown promise in mitigating lead toxicity through effective passivation, primarily by forming hydrogen bonds (H-bonds) between functional groups of the ligands and the perovskite structure. In this minireview, we explore the critical role of H-bonds in stabilizing PSCs by enhancing the structural integrity of the perovskite layer and reducing lead leakage. Furthermore, we discuss the contribution of these ligands in defect passivation, hydrophobicity, self-encapsulation, cross-linking, and self-healing mechanisms. These insights will highlight the multi-functional capabilities of ligands in improving the long-term stability and durability of PSCs, offering pathways to address current challenges in their commercialization., (© 2024 Wiley-VCH GmbH.)

Nanocarriers show great promise in drug delivery but face challenges in stability, uniformity, and morphology control. This work introduces an enhanced mixing process to overcome these obstacles, specifically aiming to produce consistently sized poly(lactic-co-glycolic) acid (PLGA) nanoparticles loaded with anti-tumor drugs. By innovatively integrating a pulsation dampener into the microfluidic channels of a continuous flow preparation system, the flow stability of piston pumps is improved nearly tenfold. Consequently, large-scale production of uniformly sized nanoparticles with customizable dimensions is achieved through nanoprecipitation. Furthermore, incorporating terminal double-bond-functionalized poly(lactic-co-glycolic acid)-b-poly(ethylene glycol)-maleimide (PLGA-PEG-Mal) enables these nanoparticles to act as nano-crosslinkers. This facilitates in situ crosslinking with thiolated hyaluronic acid via a spontaneous thiol-ene coupling reaction under physiological conditions, allowing for minimally invasive drug administration and significantly enhancing localized drug retention. The material's degradability in the presence of endogenous enzymes ensures controlled drug release, as demonstrated with the anti-tumor drug doxorubicin (DOX). Validation in a murine breast cancer model shows reduced toxicity and a substantial reduction in tumor weight compared to the free DOX group. These findings confirm the approach's effectiveness for breast cancer treatment and pave the way for innovative solutions in nanomedicine, providing a practical microfluidic mixing system for the design and large-scale production of nanomedicines., (© 2024 Wiley‐VCH GmbH.)