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Atomic precise chiral molecules with all‐hydrocarbon backbones, such as helicenes and related π‐extended derivatives, attract critical interests due to their great application potential in many fields (e. g. chiral optical materials, asymmetric catalysis, and molecular machines). Herein, the main development of these molecules in the past decade was summarizes, including enantioselective synthesis of helicenes, helicene with extension along with perpendicular to the helical axis, as well as π‐extended following both directions, namely along with helix axis and perpendicular to the helical axis direction. [ABSTRACT FROM AUTHOR]

Background: Radiation damage to salivary gland is inevitable in head and neck cancer patients receiving radiotherapy. Safe and effective treatments for protecting salivary glands from radiation are still unavailable. Mitochondrial damage is a critical mechanism in irradiated salivary gland; however, treatment targeting mitochondria has not received much attention. Nicotinamide is a key component of the mitochondrial metabolism. Here, we investigated the effects and underlying mechanisms of nicotinamide on protecting irradiated submandibular gland.Methods: Submandibular gland cells and tissues were randomly divided into four groups: control, nicotinamide alone, radiation alone, and radiation with nicotinamide pretreatment. Cell viability was detected by PrestoBlue cell viability reagent. Histopathological alterations were observed with HE staining. Pilocarpine-stimulated saliva was measured from Wharton's duct. Cell apoptosis was determined by flow cytometry and terminal deoxynucleotidyl transferase dUTP nick-end labeling assay. Nicotinamide phosphoribosyl transferase was examined with immunofluorescence. The levels of nicotinamide adenine dinucleotide, mitochondrial membrane potential, and adenosine triphosphate were measured with the relevant kits. The mitochondrial ultrastructure was observed under transmission electron microscopy.Results: Nicotinamide significantly mitigated radiation damage both in vitro and in vivo. Also, nicotinamide improved saliva secretion and reduced radiation-induced apoptosis in irradiated submandibular glands. Moreover, nicotinamide improved nicotinamide phosphoribosyl transferase and the levels of nicotinamide adenine dinucleotide/adenosine triphosphate and mitochondrial membrane potential, all of which were decreased by radiation in submandibular gland cells. Importantly, nicotinamide protected the mitochondrial ultrastructure from radiation.Conclusion: These findings demonstrate that nicotinamide alleviates radiation damage in submandibular gland by replenishing nicotinamide adenine dinucleotide and maintaining mitochondrial function and ultrastructure, suggesting that nicotinamide could be used as a prospective radioprotectant for preventing radiation sialadenitis. [ABSTRACT FROM AUTHOR]

In this corrigendum to the original article, we have included a revised Fig 2 (I) with the right staining image as shown in this corrigendum (Figure 2), to address the error in the original article. Keywords: CRSwNP; epithelial remodeling; HIPPO; IL-13; YAP EN CRSwNP epithelial remodeling HIPPO IL-13 YAP 713 716 4 02/01/22 20220201 NES 220201 To Editor: In Feb 2021, we published a letter titled "Role of yes-associated protein in interleukin-13 induced nasal remodeling of chronic rhinosinusitis with nasal polyps" in Allergy (PMID: 33301614; 10.1111/all.14699). We would like to emphasize, however, that this error did not affect the results and conclusion of the article as the error stemmed from misplacing of the IF image at the wrong grouping column during the preparation of the manuscript revision. [Extracted from the article]

Keywords: CRSwNP; epithelial remodeling; HIPPO; IL-13; YAP EN CRSwNP epithelial remodeling HIPPO IL-13 YAP 600 604 5 02/20/21 20210201 NES 210201 Chronic rhinosinusitis (CRS) is a common otolaryngologic disease. IF results on day 2 (A-D) and day 24 (E-H), showed that IL-13+VP treatment resulted in a decreased basal cell percentage (D, H), decreased YAP activity in basal cells (B, F), and a decreased basal cell proliferation level (C, G). Generally, YAP inhibits epithelial differentiation.8 However, our results demonstrated that YAP can also promote goblet cell differentiation and YAP inhibitor reversed IL-13-induced goblet cell hyperplasia. [Extracted from the article]

Metal–organic frameworks (MOFs) have been extensively explored as advanced chemical sensors in recent years. However, there are few studies on MOFs as acidic gas sensors, especially proton conductive MOFs. In this work, two new proton‐conducting 3D MOFs, {[Co3(p‐CPhHIDC)2(4,4′‐bipy)(H2O)]⋅2 H2O}n (1) (p‐CPhH4IDC=2‐(4‐carboxylphenyl)‐1 H‐imidazole‐4,5‐dicarboxylic acid; 4,4′‐bipy=4,4′‐bipyridine) and {[Co3(p‐CPhHIDC)2(bpe)(H2O)]⋅3 H2O}n (2) (bpe=trans‐1,2‐bis(4‐pyridyl)ethylene) have been solvothermally prepared and investigated their formic acid sensing properties. Both MOFs 1 and 2 show temperature‐ and humidity‐dependent proton conductive properties and exhibit optimized proton conductivities of 1.04×10−3 and 7.02×10−4 S cm at 98 % relative humidity (RH) and 100 °C, respectively. The large number of uncoordinated carboxylic acid sites, free and coordination water molecules, and hydrogen‐bonding networks inside the frameworks are favorable to the proton transfer. By measuring the impedance values after exposure to formic acid vapor at 98 % or 68 % RH and 25 °C, both MOFs indicate reproducibly high sensitivity to the analyte. The detection limit of formic acid vapor is as low as 35 ppm for 1 and 70 ppm for 2. Meanwhile, both MOFs also show commendable selectivity towards formic acid among interfering solutions. The proton conducting and formic acid sensing mechanisms have been suggested according to the structural analysis, Ea calculations, N2 and water vapor absorptions, PXRD and SEM measurements. This work will open a new avenue for proton‐conductive MOF‐based impedance sensors and promote the potential application of these MOFs for indirectly monitoring the concentrations of formic acid vapors. [ABSTRACT FROM AUTHOR]

Keywords: chiral; carbon-rich molecule; heliceneThe Front Cover shows atomic precise chiral molecules with all‐hydrocarbon backbones, such as helicenes and related π‐extended derivatives. Such molecules attract critical interests due to their great application potential in many fields (e.g., chiral optical materials, asymmetric catalysis, and molecular machines). More information can be found in the Review by Han‐Yuan Gong et al...By Li‐Jun Peng; Xin‐Yue Wang; Zhi‐Ao Li and Han‐Yuan GongReported by Author; Author; Author; Author [Extracted from the article]