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In this mixed-method study of education in the responsible conduct of research (RCR) in psychology, phase one survey respondents (n = 141) reported that faculty and students were familiar with RCR standards and procedures to educate them were believed to be adequate. However, educational methods varied widely. In phase two, seven survey respondents completed in-depth interviews assessing RCR training and education and research review procedures. Educational methods through which RCR content was presented included the following ones: traditional (lectures), technical (web-based), and experiential (internships), but RCR was often minimally considered in the formal curriculum. Our results suggest that psychology training programs might benefit from more formal consideration of RCR education and training in the curriculum. [ABSTRACT FROM AUTHOR]

Given the prevalence of unethical behavior in research, whistleblowing may serve an important policing function. Despite this potential value of whistleblowing to organizations, engaging in this type of activity often has negative ramifications for those who choose to blow the whistle. Organizations may fail to provide adequate support for these individuals. In order to help inform best practices for organizations in terms of whistleblowing support infrastructure, the present effort content analyzed interviews with university faculty members regarding ethical decision making in which whistleblowing was a topic. Relevant themes in these interviews are discussed. [ABSTRACT FROM AUTHOR]

The concept of self-plagiarism frequently elicits skepticism and generates confusion in the research ethics literature, and the ethical status of what is often called “textual recycling” is particularly controversial. I argue that, in general, self-plagiarism is unethical because it is deceptive and dishonest. I then distinguish several forms of it and argue against various common rationalizations for textual recycling. I conclude with a discussion of two instances of textual recycling, distinguishing them in terms of their ethical seriousness but concluding that both are ethically problematic. [ABSTRACT FROM AUTHOR]

Studies have indicated that the number and frequency of fraudulent publications being retracted are not subsiding even with greater awareness of such incidents in the recent decades. In this study, the trends of retraction period, number of citations and coauthors of 5 selected researchers who had ≥ 15 fraudulent publications retracted were analyzed. The obtained results shows that the retraction period is 48.96 ± 32.16 months for the 113 publications affiliated to the 5 studied researchers. There are a total of 180 coauthors with 6.40 ± 3.26 coauthors per researcher's retracted publication. The linear regression analysis indicates that there is limited correlation (R2= .008) between the citation counts and retraction period. Thepvalue for multiple F-tests to assess the number of coauthors to a fraudulent publication on an interresearcher basis is found to be ranging from < .001 to .458. It is also found that a better correlation (R2= .592) exists between the likelihood of a researcher to involve different individuals for isolated fraudulent publications while only selecting very few to be their frequent coauthors of their mischievous acts. With this study, the possible use of coauthors as a strategy for publishing fraudulent work and a potential approach to tighten coauthorship are discussed. [ABSTRACT FROM AUTHOR]

The ‘individualised accounting questions’ (IAQ) technique set out in this paper encourages independent active learning. It enables tutors to set individualised accounting questions and construct an answer grid that can be used for any number of students, with numerical values for each student's answers based on their student enrolment number. The individualised questions reduce the risk of collusion and thus allow tutors to set accounting coursework assessments that contribute to final grades in a manner that incentivises students to do them in their own time, drawing on teaching materials and helping them to develop competency. The method also allows specific individualised feedback, and has been used successfully by the authors and found to encourage students to work independently. [ABSTRACT FROM PUBLISHER]

International student enrolments globally have grown substantially over the first decade of the twenty-first century. In the context of Australia, the higher education (HE) sector and specifically the accounting discipline grew during this time, together with the growth in the demand for qualified accountants. Australia was attractive to international students not only because of the prospect of obtaining an overseas accounting qualification, but also the opportunities presented for Permanent Residency given the local skill shortage in accounting. However, a set of reforms to the skilled migration policy announced early in 2010 had implications for the established nexus between accounting education and migration. This paper uses comparative hypothetical case studies to illustrate the impact on the opportunities for international students completing accounting degrees to seek Permanent Residency in Australia. The findings contribute to an understanding of the trend in international student enrolments and, more broadly, the implications for universities in terms of revenue generation from international enrolments. The paper informs accounting educators of some of the pedagogical consequences of the recruitment of international students when enrolments are influenced by government policy, especially immigration policy changes. [ABSTRACT FROM PUBLISHER]

Self- and peer-assessment of student work is an area that is under-researched in the accounting education literature, although the subject area of study seems to influence the results obtained in prior studies. The current study contributes to the literature by examining the accuracy and construct validity of self- and peer-assessment by accounting students. It also investigates students’ views about these exercises. The findings show that whilst the self- and peer-assessment of students appear to be neither accurate nor valid, the students are positive about the impact of these procedures on their learning experience. These findings indicate that, although instructors might not rely on self- and peer-assessment as measures of students’ performance for the purpose of summative assessment, the exercise may prove useful for formative assessment because it can promote a wide range of transferable skills. [ABSTRACT FROM PUBLISHER]

We examine how student attitudes toward their group, learning method, and perceived development of professional skills are initially shaped and subsequently evolve through multiple uses of team exams. Using a Tobit regression model to analyse a sequence of 10 team quizzes given in a graduate-level tax accounting course, we show that there is an anchoring effect, in that in later rounds satisfaction on all dimensions rests on the foundation laid in the initial round. Subsequently, however, self-perceptions and the perception of others may influence satisfaction on a particular dimension. We also find that the satisfaction with one's group tends to increase when students make more correct switches but decreases when there is greater disagreement among the group. Furthermore, satisfaction with team exams tends to lessen, and to an increasing extent over time, as the number of errors a student has committed on the most recent quiz increases. [ABSTRACT FROM PUBLISHER]

The author discusses his experiences as a Chinese international lecturer working in the accounting department of a British university, focusing on how he encouraged use of the Mind Maps (MM) method of graphical representation in teaching and learning. He comments on how the use of MM principals improved the clarity of teaching materials, increased his self-confidence as a lecturer, and improved his job satisfaction.

This Teaching Resource outlines and reflects upon the use of an innovative corporate associate partnership scheme as part of the delivery of an Auditing course to final year undergraduate Accounting students at a university in the UK. It outlines the motivations behind a practitioner's involvement in teaching delivery, along with the formulation, design, and implementation of the scheme. The authors provide insights from their experiences so that others, at different institutions, may replicate or adapt such a scheme. This could be extended into subject areas other than Auditing, with the delivery pattern being altered as appropriate to suit the needs of other institutions and associated practitioners. The Teaching Resource provides reflections on the partnership from the students, the module tutor, and the associate involved in its delivery. [ABSTRACT FROM PUBLISHER]

Financial services are an increasingly important sector in modern economies, yet many accounting and auditing texts focus on manufacturing and retailing. This teaching note describes the role of financial institutions in transforming long-term, difficult-to-sell assets into short-term bank accounts. This is referred to as liquidity transformation. The social benefits and risks of liquidity transformation are described. The social benefit occurs due to the increased liquidity provided by the bank to depositors. The risk comes in the form of a bank run, wherein difficult-to-sell assets cannot be redeemed in time to cover the rapid and unexpected withdrawals of depositors. The financial statements of a financial institution are presented and the issue of valuation is discussed. Finally, practical relevance for accounting students is enhanced by including discussions of historical precedents and of implications for financial reporting and auditing. [ABSTRACT FROM PUBLISHER]

This paper reviews literatures on Web geographic information system decision support system (Web GIS DSS), its development, and applications in irrigation water management. The purpose is to summarize and synthesize the most useful approach used in developing web applications for irrigation water management. It encompassed varieties of reports and publications for wider understanding of the topic. The review provides the concept, methodologies, and various uses of the applications. Critical analysis on the choice of structural framework and Graphical User Interface has been discussed. Among problems encountered during system development were: data management, security, user needs, etc. The use of Web GIS DSS is gaining more attention from Irrigation Engineers, System Developers, and Cartographers. Web GIS and especially the real-time capability can be of importance in solving many problems regarding irrigation water management. When system is well design, it can be safe, cheap, and maximize profit of any business. The future of development and application of web GIS applications were well discussed by presenting the latest technology in the systems development. There is need for standardization of some aspect of methodologies issues concerning information security and customization to ensure flexibility and viability. The web GIS is simply the future of many spatial transactions. [ABSTRACT FROM AUTHOR]

High temperature has deleterious impacts on tomato growth and development and limits its production. Acetyl salicylic acid (ASA) and 24-epibrassinolide (EBL) have been widely reported as stress-ameliorating agents. The effect of exogenous application of varying levels of EBL (0.75, 1.5, and 3 µM) and ASA (0.25, 0.75, and 1.25 mM) on root activity (RA) in terms of 2,3,5 triphenyl tetrazolium chloride (TTC) reduction and root morphological features was evaluated in four-week-old tomato seedlings (cultivar: Mei Jie Lo) grown under high-temperature stress (46°C/4 h per day) for 21 days. The daily heat stress treatment almost ceased the root growth of chemically untreated seedlings. However, both EBL and ASA significantly attenuated the deleterious impacts of heat stress to different extents regarding root activity, total root length, surface area, volume, and number of nodes and connections. Different concentrations demonstrated signature effects. EBL (3 µM) was over all the best treatment to improve root activity whereas ASA (0.25 mM) best enhanced root architecture (net length, volume, and area) as compared to the untreated heat-stressed controls. However, EBL (3 µM) and ASA (1.25 mM) slightly inhibited mean root diameter. It is concluded that under high-temperature conditions, the exogenous EBL and ASA in studied doses improve root morphological features and root activity, hence enhance heat stress tolerance. Both chemical agents can be potential candidates in practical agriculture for extension of tomato growth period in summer by virtue of their heat stress amelioration ability. [ABSTRACT FROM AUTHOR]

Grain yields are presented from a 10-year field trial with four tillage regimes (annual ploughing, harrowing only, ploughing/harrowing alternate years and minimum tillage) on clay loam. We also present soil physical analyses and use the compaction verification tool (CVT) to assess compaction on plots with annual ploughing and minimum tillage, after using slurry tankers with contrasting wheel loads (4.1 Mg, 6.6 Mg) and wheeling intensities (1×/10×) in the 11th trial year, and yields monitored two years after compaction. Winter wheat yields in the period before compaction were strongly affected by tillage, with annual ploughing giving on average 24% higher yield than direct drilling. Both wheat and oats were far less affected in treatments with harrowing only or ploughing/harrowing alternate years, on average within 6% of annual ploughing. Yields after compaction were affected by both previous tillage and compaction intensity. In the first year, single wheeling after annual ploughing gave 23% yield reduction with 4.1 Mg wheel load and 28% reduction with 6.6 Mg wheel load, whilst multiple wheeling gave 14% reduction at 6.6 Mg wheel load. Yield reductions after minimum tillage ranged from 63% (single wheeling with 4.1 Mg) to 100% (multiple wheeling with 6.6 Mg). Similar trends were found in the second year. The soil physical data indicated that all wheeling led to changes in bulk density, pore sizes and permeability in both topsoil and subsoil on both sampled tillage plots. However, effects in the subsoil were partly masked by the soil's high initial bulk density, partly due to its high clay content. The CVT, which plots air capacity against hydraulic conductivity, suggested some harmful compaction on both plots, with the minimum tillage plot being less affected than the ploughed plot. However, yield results did not support this conclusion, indicating that other factors limited yields on the minimum tilled plot. [ABSTRACT FROM AUTHOR]

In arid and semiarid regions, water infiltration is often affected by the soil surface conditions, such as the soil crusts and soil roughness. The objective of this laboratory study was to assess the effects of soil crusts and tillage treatments on soil infiltration in the Loess Plateau of China. A simulated rainfall storm at 80 mm h−1rate was applied to soil boxes set to slopes of 5°, 10°, 15° and 20° with two soil surface conditions (crusted and uncrusted) and three tillage treatments (contour tillage [CT], artificial digging [AD] and straight slope [SS]) to investigate the infiltration rates. The results show that the infiltration rate was always lower under the SS treatment than under the CT and AD treatments. The time interval to the steady state was shorter under the SS (10 min) than under the CT and AD treatments (15–20 min). The final infiltration rate was nearly the same under the CT treatment and AD treatment; whereas, the SS treatment resulted in the lowest final infiltration rate. The infiltration rates were always greater in soils without crusts than in soils with crusts. The slopes, soil crusts and tillage treatments had significant (p< 0.001) effects on the cumulative infiltration rates. The combined effects of the slopes and tillage treatments on the cumulative infiltration rates were much more significant (p< 0.01) than the other combined effects (p< 0.05). [ABSTRACT FROM AUTHOR]

An introduction is presented in which the editor discusses various reports within the issue on topics including grammaticalization, role of subjectification in the development of intensifiers, and Traugottian view about subjectification.

One may sometimes get the impression that (inter)subjectification is regarded as an aspect of grammaticalization, so that (roughly speaking) the more (inter)subjective an expression has become, the more grammaticalized it is. We propose that the two phenomena are better understood as clearly distinct. Grammaticalization in our view consists in a process whereby an expression becomesancillaryin relation to another expression (type), thereby at the same time creating a structural relation and a difference in prominence status. (Inter)subjectification, on the other hand, is purely a change in conventional semantic content. However, there is a particular type of diachronic process in which the two may go hand in hand. We try to give a precise account of what that type is and how it differs from other, related changes. [ABSTRACT FROM AUTHOR]

In this paper, we argue that an expanded conception of the distinction between speaker-oriented and subject-oriented inferences is crucial for understanding the motivations and mechanisms of semantic change in grammaticalization and subjectification, on the one hand, and for clarifying the links between semantic change and reductive formal changes, on the other. Speaker-oriented inferences have significant consequences, leading to the relaxation of selectional restrictions on a construction. In turn, the relaxation of selectional restrictions can create conditions in which the type and token frequency of a construction can rise considerably. Furthermore, changes in the selectional restrictions on a construction can themselves catalyze semantic change by coercing listeners into new form–function pairings. This framework is applied to allative futures, a typological comparative concept developed in order to compare structurally diverse future tenses. Following the typological discussion, a diachronic case study of the emergence and grammaticalization of a verbless allative future in Ancient Egyptian is presented. Such verbless allative futures provide evidence against assumptions that purpose constructions as such are not grammaticalized as future tense constructions (Schmidtke-Bode 2009). Rather, they corroborate earlier hypotheses that it is the allative component of source constructions that crucially leads to intention meanings, and from intention to prediction (see, e.g., Bybee, Pagliuca, and Perkins 1994). [ABSTRACT FROM AUTHOR]

This article proposes an analysis of the historical changes in the aspectual system of Greek as a process of grammaticalization and subjectification, thus challenging the traditional view of Greek verbal aspect as a stable and in fact extremely conservative category, possibly very close to that of Proto-Indo-European. Specifically, the claim put forward here is that the original tripartite morphological opposition (Aorist–Present–Perfect stems) expressed Aktionsart, i.e. lexical aspect, distinctions (punctuality/telicity–durativity/atelicity–state, respectively) while the modern binary morphological opposition (Aorist–Present stems) expresses the purely aspectual perfective–imperfective opposition. Since Aktionsart is based on inherent features of the action/state denoted by the verb while aspect expresses the speaker's point of view, this constitutes a shift from objectivity to subjectivity as well as a somewhat atypical grammaticalization process. [ABSTRACT FROM AUTHOR]

This article presents a corpus-based analysis of the semantic developments of the three most “prototypical” Dutch modals,kunnen‘can’,mogen‘may’, andmoeten‘must’. It focuses on the implications for current concepts of (inter)subjectification. The three modals turn out not to behave in a uniform way and to show different diachronic profiles:kunnenandmogendo butmoetendoes not show clear processes of (inter)subjectification, whilekunnenis a much “younger” modal thanmogenandmoeten. In terms of paths of semantic change, the investigation shows that evolutions toward more (inter)subjective meanings are often not linear. Even if they predominantly emerge from one other meaning, new meanings can have secondary sources. Furthermore, evolutions often happen in parallel, with one specific meaning serving as the source for several others (e.g., deontic, epistemic/evidential, and directive meanings typically all evolve in parallel from a dynamic modal meaning). [ABSTRACT FROM AUTHOR]

This diachronic study intends to trace the origin and development of the intensifying adverbdead. By means of a selective collocational analysis, the paper shows howdeadhas followed a parallel path of development to other intensifiers, namely descriptive meanings > subjective or affective meanings > intensifying meanings (Adamson 2000). In particular,deadoriginally expressed more literal or concrete senses, but came to denote increasingly more abstract meanings until its final reanalysis as a general intensifier, thus instantiating a path of gradual subjectification and grammaticalization. TheMiddle English Dictionaryand theOxford English Dictionarywere consulted as preliminary sources of data. Materials from various diachronic corpora and online collections of electronic texts have been selected to expand the information initially provided by these historical dictionaries. [ABSTRACT FROM AUTHOR]

Background. Understanding the dose-response of the lung in order to minimize the risk of radiation pneumonitis (RP) is critical for optimization of lung cancer radiotherapy. We propose a method to combine the dose-response relationship for RP in the landmark QUANTEC paper with known clinical risk factors, in order to enable individual risk prediction. The approach is validated in an independent dataset. Material and methods. The prevalence of risk factors in the patient populations underlying the QUANTEC analysis was estimated, and a previously published method to adjust dose-response relationships for clinical risk factors was employed. Effect size estimates (odds ratios) for risk factors were drawn from a recently published meta-analysis. Baseline values for D50 and γ50 were found. The method was tested in an independent dataset (103 patients), comparing the predictive power of the dose-only QUANTEC model and the model including risk factors. Subdistribution cumulative incidence functions were compared for patients with high/low-risk predictions from the two models, and concordance indices (c-indices) for the prediction of RP were calculated. Results. The reference dose- response relationship for a patient without pulmonary co-morbidities, caudally located tumor, no history of smoking, < 63 years old, and receiving no sequential chemotherapy was estimated as D500 = 34.4 Gy (95% CI 30.7, 38.9), γ500 = 1.19 (95% CI 1.00, 1.43). Individual patient risk estimates were calculated. The cumulative incidences of RP in the validation dataset were not significantly different in high/low-risk patients when doing risk allocation with the QUANTEC model (p = 0.11), but were significantly different using the individualized model (p = 0.006). C-indices were significantly different between the dose-only and the individualized model. Conclusion. This study presents a method to combine a published dose-response function with known clinical risk factors and demonstrates the increased predictive power of the combined model. The method allows for individualization of dose constraints and individual patient risk estimates. [ABSTRACT FROM AUTHOR]

Conclusions: Human neural progenitor cells can differentiate into spiral ganglion-like cells when exposed to inner ear-associated growth factors. The phenotype bears resemblance to human sphere-derived neurons. Objective: To establish an in vitro model for the human auditory nerve to replace and complement in vivo animal experiments and ultimately human in vivo transplantation. Methods: Human neural progenitors were differentiated under conditions developed for in vitro survival of human primary spiral ganglion culture with media containing growth factors associated with inner ear development. Differentiation was documented using time-lapse video microscopy. Time-dependent marker expression was evaluated using immunocytochemistry with fluorescence and laser confocal microscopy. Results: Within 14 days of differentiation, neural progenitors adopted neural phenotype and expressed spiral ganglion-associated markers. [ABSTRACT FROM AUTHOR]

Conclusion: Inhibition of thioredoxin reductase (TrxR) may be a contributing factor in cisplatin-induced ototoxicity. Direct exposure of organ of Corti to cisplatin and oxaliplatin gives equal loss of hair cells. Objectives: Platinum-containing drugs are known to target the anti-oxidant selenoprotein TrxR in cancer cells. Two such anti-cancer, platinum-containing drugs, cisplatin and oxaliplatin, have different side effects. Only cisplatin induces hearing loss, i.e. has an ototoxic side effect that is not seen after treatment with oxaliplatin. The objective of this study was to evaluate if TrxR is a target in the cochlea. Loss of outer hair cells was also compared when cisplatin and oxaliplatin were administered directly to the organ of Corti. Methods: Organ of Corti cell culture was used for direct exposure to cisplatin and oxaliplatin. Hair cells were evaluated and the level of TrxR was assessed. Immunohistochemical staining for TrxR was performed. An animal model was used to evaluate the effect on TrxR after treatment with cisplatin and oxaliplatin in vivo. Results: Direct exposure of cochlear organotypic cultures to either cisplatin or oxaliplatin induced comparable levels of outer hair cell loss and inhibition of TrxR, demonstrating that both drugs are similarly ototoxic provided that the cochlea becomes directly exposed. [ABSTRACT FROM AUTHOR]

Conclusion: Facial nerve dehiscence (FND) and ossicular injury occurred more frequently in patients with cholesteatomatous than non-cholesteatomatous otitis media. Objective: FND and ossicular injury commonly occur intraoperatively in patients with otitis media, both with and without cholesteatoma. This study was designed to analyze differences in FND and ossicular injury between patients with cholesteatomatous and non-cholesteatomatous otitis media. Methods: Patients who underwent tympanomastoidectomy due to otitis media from January 2010 to July 2012 were analyzed retrospectively. Clinical features (age, sex, bacteria, and severity of preoperative hearing loss) and intraoperative findings (FND and state of ossicular injury) were compared in patients with cholesteatomatous and non-cholesteatomatous otitis media. Results: Of 212 patients with otitis media, 148 (69.8%) had non-cholesteatomatous and 64 (30.2%) had cholesteatomatous otitis media. Of these groups, 88.6% and 88%, respectively, had positive bacterial cultures. Facial nerve dehiscence was detected in 41 patients (27.7%) with non-cholesteatomatous and 41 (64.0%) with cholesteatomatous otitis media. Dehiscence of the tympanic segment was most frequently observed in both groups. Ossicular injury was detected in 52 (35.1%) and 51 patients (78.1%), respectively. Erosion was most frequent in the incus, followed by the stapes and malleus. [ABSTRACT FROM AUTHOR]

Conclusions: Potsic's staging system is a clinically useful procedure for evaluating the extent of congenital cholesteatoma (CC). Objectives: We investigated the clinical features, presenting symptoms, and surgical results of CC according to Potsic's staging system. Methods: A total of 71 patients who had undergone surgery at our hospital were retrospectively analyzed for presenting symptoms, the location of cholesteatoma, and surgical results according to Potsic's staging system. Results: Of the 71 patients, 21 were classified as Potsic stage I, 9 as stage II, 31 as stage III, and 10 as stage IV. More than half of the patients with early-stage CC (stages I and II) were diagnosed asymptomatically by a chance visit to a clinic or on ear screening. Others were diagnosed following a complaint of hearing loss, acute otitis media, or otitis media with effusion. The location of CC varied somewhat by stage. In stage I CC, the most frequent location was behind the anterior-superior quadrant of the tympanic membrane; however, in stage III CC, it was behind the posterior-superior quadrant. All patients were treated surgically. Recurrence was detected in 2 of the 71 patients (2.8%); both had stage II CC. Recurrent lesions were removed during revision surgery. [ABSTRACT FROM AUTHOR]

Conclusion: The levofloxacin thermo-sensitive gel prepared using 17% poloxamer 407 (P407) can successfully treat suppurative otitis media (SOM) through the well-controlled release of levofloxacin targeted against the inflammation. Objective: To evaluate the preparation method and therapeutic effect of levofloxacin thermo-sensitive gel used in the treatment of SOM. Methods: The phase inversion temperatures of 16%, 17%, 18%, 19%, and 20% P407 or P407 solution with 3 mg/ml levofloxacin were determined and the one close to 34°C was selected as the optimal concentration. Then a model of SOM was induced by injection of 0.1 ml Staphylococcus aureus (1 × 108/L) in the left ear of 32 Sprague Dawley (SD) rats. Normal saline injected in the right ear was used as the control. Then rats were treated with 0.1 ml normal saline (group A), levofloxacin (group B), P407 (group C), and levofloxacin thermo-sensitive gel (group D) ( n = 8). The tympanic membranes were evaluated by otoscopy and hematoxylin and eosin (H&E) staining. Results: The optimal concentration of P407 was 17% and the release of levofloxacin in thermo-sensitive gel followed zero-order kinetics. Levofloxacin thermo-sensitive gel and levofloxacin drops could both alleviate the local inflammation in the first 3 days, but levofloxacin drops could not inhibit the recurrence of SOM, while the levofloxacin gel performed continuous drug delivery into inflammation without recurrence. [ABSTRACT FROM AUTHOR]

Conclusion: The increased expression of Dec-205, Bcl-10, Tim-3, and Trem-1 mRNAs indicates that these pattern recognition receptors are involved in the pathogenesis of cholesteatoma. Objective: Changes in expression of pattern recognition receptors may be associated with immune responses in patients with cholesteatoma. We therefore assessed the levels of expression of Dec-205, Bcl-10, Tim-3, and Trem-1 mRNAs associated with innate immune responses in patients with cholesteatoma. Methods: Cholesteatoma specimens were collected from 23 patients diagnosed with acquired cholesteatoma from August 2010 to July 2012. The posterior auricular skin of each patient was used as control. The levels of expression of Dec-205, Bcl-10, Tim-3, and Trem-1 mRNA were assessed quantitatively using real-time RT-PCR and correlated with sex, hearing level, the presence of bacteria, and the need for repeat surgery. Results: The levels of expression of Dec-205, Bcl-10, Tim-3, and Trem-1 mRNAs were significantly higher in cholesteatoma than in control skin samples ( p < 0.05 each). However, mRNA abundance was not associated with patient sex, hearing level, presence of bacteria or history of reoperation ( p > 0.05 each). [ABSTRACT FROM AUTHOR]

Conclusion: Otitis media with effusion (OME) can affect the development of mastoid in children. For younger children (<12 years old), surgical intervention may promote the development of mastoid. It is highly recommended that patients with severe tympanic membrane retraction have tympanostomy tubes to improve the circulation in the middle ear as early as possible. Objective: To investigate the effect of OME and its clinical intervention on the development of mastoid in children. Methods: A total of 46 children with OME were divided into 2 groups according to their ages. In group 1, 26 cases (0-6 years old) were treated for approximately 2 months, while in group 2, 20 cases (7-15 years old) were treated for 10 months. The treatments included tympanic effusion incision or catheterization, and adenoidectomy and/or bilateral tonsillectomy. Before and 6 months after treatments, patients were examined by bilateral temporal bone CT scanning, pure-tone audiometry, and tympanometry. 3-D volumetric reconstruction was then performed to determine the morphological properties of each patient's mastoid. Results: After a 2-month comprehensive treatment, the volume of mastoid was close to that in normal children, indicating that it could return to normal level if the treatment was completed within 2 months. In group 2, the results suggested that if the treatment lasted more than 6 months, the development of mastoid would be stalled. [ABSTRACT FROM AUTHOR]

Conclusion: The function of all the semicircular canals in patients with idiopathic benign paroxysmal positional vertigo (BPPV) in whom otoconial debris is located in the superior semicircular canal (SSC) is normal. Objective: BPPV of SSC is an infrequent entity in which otoconial debris evokes vertigo and nystagmus in the head-hanging position and during anterior flexion of the patient. Methods: We studied the vestibulo-ocular reflex (VOR) in 12 patients with this particular type of BPPV. The reflex was evoked by rapid head impulses in the plane of the three semicircular canals in the affected and the normal ear. The reflex was evaluated with a video system that analyzes the head and eye velocity: the gain (the relation between both magnitudes) was the objective measure. Results: The mean gain of VOR was within normal limits for the six semicircular canals and there were no significant differences between the same canals on each side of patients with BPPV in whom canalolithiasis was located in the SSC. However, gain asymmetry was different for each pair of canals. [ABSTRACT FROM AUTHOR]

Conclusions: The presence of orthotropic nystagmus (ON), in multiple positions, appears to predict the success of canalith repositioning maneuvers (CRMs). In this sense CRMs under video-Frenzel are informative for the immediate follow-up, although not related to the degree of disability or emotional distress. Still, attention should be given to psychological assistance even in cases of clinically cured benign paroxysmal positional vertigo (BPPV). Objective: The aim of the study was to highlight the prognostic value of nystagmus in CRMs for BPPV and its relevance for emotional and patient-perceived disability. Methods: A group of 57 patients were selected from 3 balance disorders centers. CRMs were performed under video-Frenzel control. Assessment of patient disability and positional nystagmus was performed 2 months later. Emotional (Cuestionario de Impacto Emocional del Vértigo, CIEV) and quality of life (Dizziness Handicap Inventory, DHI) impact were evaluated. Results: The posterior semicircular canal (SCC) was affected in 84.2% of cases, the horizontal SCC in 10.5%, and the anterior SCC in 5.1%. Appropriate CRMs were performed. ON was present in 67% of cases. Overall resolution after the first treatment was achieved in 56% of cases. With ON present the success rate was 63% and when not observed the rate was 42%. DHI or CIEV scores were not significantly different when comparing the presence vs absence of ON. In nine patients (16%) an abnormal CIEV score was observed after treatment, even though a cured status was achieved in six of these nine patients. [ABSTRACT FROM AUTHOR]

Conclusion: Human adipose-derived stem cells (ASCs), encapsulated in a fibrin-collagen hydrogel for the coating of an electrode array, produce sufficient amounts of neurotrophic factors and may be suitable for enhancing the bioelectric interface of cochlear implants (CIs). Objectives: To evaluate different hydrogel compositions loaded with ASCs with regard to delivery of neuroactive substances and mechanical suitability for the coating of a CI electrode array. Methods: ASCs were cultivated in hydrogels consisting of collagen and fibrin in varying fractions (0:1, 1:1, 1:2, and 1:0). The cell proliferation and viability, as well as the production of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and laminin were determined. Two hydrogel compositions were used as a coating for CI electrode arrays and tested in a scala tympani model. Results: Cell proliferation was best in collagen/fibrin hydrogel compositions (1:1 and 1:2) and increasing amounts of BDNF (up to 2.59 ng/ml) and laminin (up to 320 ng/ml) were detected. GDNF production was inconsistent and markedly lower. A sufficient coating of a CI electrode carrier in terms of stability and flexibility was achieved only with mixed compositions, although hydrogels formed bulky and uneven layers on the silicone surfaces. [ABSTRACT FROM AUTHOR]

Conclusion: Kinetic oscillation stimulation (KOS) of nasal mucosa at low frequency seems to be a possibly effective and safe short-term treatment of non-allergic nasal stuffiness. Objective: To assess the relief of rhinitis symptoms, especially stuffiness, by comparing active treatment, i.e. KOS at low frequency of the nasal mucosa, with placebo. Methods: Patients were randomized to active or placebo treatment in this double-blinded parallel design study. Treatment with an inflatable oscillating catheter was administered on day 0, and symptom scores (stuffiness, secretion, and itching) were graded daily until day 14. An overall grading of symptoms from 1 week before treatment and during 14 days thereafter was made at day 14. Eighty-six patients (52 with non-allergic perennial rhinitis, NAR; 34 with rhinitis medicamentosa, RM) were randomized, and 71 were evaluated (active treatment, n = 35; placebo, n = 36). Results: Patients with either NAR or RM who received active treatment reported reduced symptom scores by some measures, e.g. median RQSS stuffiness measure fell from 2 to 1 on a scale from 0 to 3 during the week following treatment. No significant effect was observed for patients treated with placebo. Mild side effects were reported. [ABSTRACT FROM AUTHOR]

Conclusion: Our numerical simulation model provides an accurate reflection of nasal airflow, and the results were validated by clinical measurements. Objectives: To evaluate the accuracy of a numerical simulation model of nasal airflow. Methods: Ten volunteers with normal nasal cavities underwent CT, acoustic rhinometry, and rhinomanometry. CT data were uploaded into Mimics, ICEM-CFD, Fluent, and CFD-Post software for three-dimensional modeling, finite element grid division, transient calculations, and analysis, respectively. Velocity and pressure data of airflow were obtained during the normal respiratory cycle. The accuracy of the simulation was evaluated by two methods: acoustic rhinometry measurements were used to evaluate the accuracy of the anatomic model, and rhinomanometry measurements were used to evaluate the accuracy of the nasal resistance values obtained by numerical simulation. Results: There were no significant differences between the values describing the model and the acoustic rhinometry measurements, the nasal resistance values obtained by numerical simulation. The airflow through the nasal cavity was mainly laminar. The maximum velocities were measured at the nasal valve, the amplitudes of all velocity curves at locations beyond the nasal valve were reduced. The amplitudes of the pressure curves increased from the front to the back of the airway. [ABSTRACT FROM AUTHOR]

Conclusions: Our study suggested that the major risk factors for postoperative bleeding after nasal endoscopic surgery (NES) included hypertension, long-term non-steroidal anti-inflammatory drugs (NSAIDs), and previous nasal surgery. The use of preoperative corticosteroids is a valuable measure for reducing postoperative bleeding after NES. Objectives: To explore risk factors for postoperative bleeding after NES and find effective measures to reduce or prevent the condition. Methods: A total of 641 patients who underwent NES were analyzed retrospectively. Univariate analysis and logistic regression were performed to find potential risk factors. Results: The incidence of postoperative bleeding after NES was 8.4%. Multivariate logistic regression analysis revealed that the occurrence of postoperative bleeding after NES was positively associated with hypertension, long-term NSAIDs, previous NES, and modified submucosal septoplasty, but negatively associated with the use of preoperative corticosteroids. [ABSTRACT FROM AUTHOR]

Conclusions: p53 overexpression (>5%) in the surgical margins was more valuable than in the primary tumor tissue for the prediction of local recurrence among surgically treated early glottic cancers. This is the first study to compare p53 values in both primary tumor and surgical margin tissues of the same patients with early glottic cancers. Objective: To assess the prognostic value of p53 expression in the surgical margins of early glottic cancers treated with external laryngeal surgery in the prediction of local recurrences. Methods: Fifteen patients with early glottic cancer with local recurrences (group 1) and 15 without any recurrences (group 2) were included in the study. p53 expression was determined in both the tumor and the tumor-negative surgical margins. Results: Median p53 in the primary tumor was 55% (interquartile range (IQR) = 67) and 5% (IQR = 71) in groups 1 and 2, respectively ( p = 0.178). Median p53 in the surgical margin was 11% (IQR = 13) and 2% (IQR = 2) in groups 1 and 2, respectively ( p = 0.001). In the logistic regression analysis only surgical margin p53 value was significant in the prediction of recurrences (odds ratio (OR) = 1.68, 95% CI = 1.1-2.6, p = 0.017). Receiver operating characteristic (ROC) curve analysis demonstrated that the area under the curve was 0.86 ( p = 0.002) and 0.65 ( p = 0.180) in the surgical margin and the primary tumor, respectively. [ABSTRACT FROM AUTHOR]

Conclusion: The combination of sialendoscopy and an intraductal application of corticosteroids can be recommended for children with chronic recurrent juvenile parotitis (CRJP) as there is growing evidence for a positive effect in the absence of side effects. Objective: CRJP is a disorder with painful, episodic swelling of the parotid gland in children. The majority of cases have a self-limiting character within 5-10 years, but the disease may also continue into adulthood. CRJP can occur on one or both sides and up to now the etiology has been unclear. The aim of this study was to analyze the therapeutic effect of a sialendoscopic application of corticosteroids on the clinical course of patients with CRJP. Methods: We retrospectively analyzed the clinical course of 9 children with 10 parotid glands affected by CRJP, who all underwent sialendoscopy and intraductal application of corticosteroids. In all cases the procedure was conducted under general anesthesia. The average follow-up period was 15 months. Results: There were no side effects associated with the sialendoscopy. All duct systems showed signs of chronic inflammation with an atrophic or thickened epithelium. At the follow-up visit, CRJP symptoms had completely resolved in eight children. One child still showed slight parotid swellings without the need for antibiotics. None of the parents reported that symptoms had continued at an equal level or worsened after sialendoscopy. [ABSTRACT FROM AUTHOR]

Conclusions: Galectin-1 overexpression is significantly correlated with the survival rate of patients with nasopharyngeal carcinoma (NPC). Immunohistochemical analysis of galectin-1 expression might be useful for identifying patients with a high risk of distant metastasis and for prompting timely adjuvant systemic therapy for patients with aggressive NPC. Objectives: We examined the effect of galectin-1 on the survival rate of patients with NPC. Methods: A total of 124 patients diagnosed between 1998 and 2002 with NPC without distant metastasis were enrolled in this single-center historical prospective cohort study. Immunohistochemical analysis was used to correlate the galectin-1 expression score in the cytoplasm and the survival rate of patients with NPC. Results: Patients with NPC who overexpressed galectin-1 in cytoplasm showed more aggressive tumor growth and significantly shorter disease-specific survival (DSS) ( p = 0.0037) and distant metastasis-free survival (DMFS) ( p = 0.0006) than patients with NPC who did not overexpress galectin-1. Multivariate analysis showed that galectin-1 overexpression remained prognostically independent for DSS ( p = 0.031, hazard ratio = 1.821), and DMFS ( p = 0.005, hazard ratio = 2.417), together with the advanced III-IV stages. [ABSTRACT FROM AUTHOR]

Conclusion: Alpha B-crystallin was found to be an independent prognostic marker for poor prognosis in oral cavity tumours. For oropharyngeal cancer, alpha B-crystallin had no prognostic value. Objective: The aim of this study was to see if earlier findings of alpha B-crystallin as an independent prognostic marker, and SPARC/osteonectin, PAI-1 and uPA as a prognostic combination for poor outcome in squamous cell carcinoma (SCC) of the head and neck could be confirmed in a new set of tumours. Methods: In a consecutive series of patients, assessed and primarily treated at a tertiary referral centre, histological sections from 55 patients with oral and SCC (OOPHSSC) with complete clinical data and follow-up were obtained. Oral and oropharyngeal tumours were studied separately. Immunohistochemical detection of alpha B-crystallin, SPARC/osteonectin, PAI-1 and uPA expression was performed. Results: Thirty-five patients had an oral tumour and 20 patients an oropharyngeal tumour. Twenty-five oral tumours stained negatively and 10 positively for alpha B-crystallin. For oropharyngeal tumours the figures were 15 negatively and 5 positively. Median disease-specific survival (DSS) for both sites was 33.8 and 11.9 months, for negative and positive alpha B-crystallin staining, respectively ( p = 0.046). For the oral cavity, median DSS was 27.3 months for negative tumours and 7.5 months for positive tumours ( p = 0.012). Corresponding figures for oropharyngeal tumours were 33.8 and 34.1 months ( p = 0.95). Thus, significance in survival was only found in oral cavity tumours. In multivariate analyses there were no significant differences in DSS in the oropharyngeal group when adjusted for tumour size (T status) and presence of neck node metastasis (N status). In the oral cavity group, the significantly better DSS for negative tumours became even stronger when adjusted for T and N status. No statistical difference was found in DSS between positive and negative staining for SPARC/osteonectin, PAI-1 or uPA. [ABSTRACT FROM AUTHOR]

Laser range finders (LRF’s) are non-invasive sensors which can be used for high-precision and anonymous tracking of pedestrians in social environments. Such sensor networks can be used in robotics to assist in navigation and human–robot interaction. Typically, multiple LRF’s are used together for such tasks, and the relative positions of these sensors must be precisely calibrated. We propose a technique for estimating relative LRF positions using observations of social groups in the pedestrian flow as keypoint features for determining coarse estimates of relative sensor offsets. The most likely offset is estimated using a generalized Hough transform and used to identify sets of possible shared observations of individual pedestrians between pairs of sensors. Outliers are rejected using the RANSAC technique, and the resulting shared observations from each sensor pair are combined into a constraint matrix for the sensor network, which is solved using least-squares minimization. Results show calibration accuracy of sensor positions within 34 mm and 0.51°, and an analysis of pedestrian data collected from ubiquitous networks in three public and commercial spaces shows that the proposed calibration technique enables pedestrian tracking within 11 cm accuracy. [ABSTRACT FROM AUTHOR]

Learning task-space tracking control on redundant robot manipulators is an important but difficult problem. A main difficulty is the non-uniqueness of the solution: atask-spacetrajectory has multiple joint-space trajectories associated, therefore averaging over non-convex solution space needs to be done if treated as a regression problem. A second class of difficulties arise for those robots when the physical model is either too complex or even not available. In this situation machine learning methods may be a suitable alternative to classical approaches. We propose a learning framework for tracking control that is applicable for underactuated or non-rigid robots where an analytical physical model of the robot is unavailable. The proposed framework builds on the insight that tracking problems are well defined in thejointtask- and joint-space coordinates and consequently predictions can be obtained via local optimization. Physical experiments show that state-of-the art accuracy can be achieved in both online and offline tracking control learning. Furthermore, we show that the presented method is capable of controlling underactuated robot architectures as well. [ABSTRACT FROM AUTHOR]

Set point tracking control of autonomous underwater vehicle (AUV) via robust model predictive control (RMPC) is considered. Input-constrained RMPC with integral action, which has been developed in our previous work, is used to control the AUV in this study. In order to derive a RMPC control rule, non-linear dynamics of AUV with six degree of freedom is linearized at certain operating points. So, horizontal and vertical plane dynamics of system are represented by linear models which have polytopic uncertainties. Since the derived control rule will be used in real time, the computation time should be reduced. To overcome this computational time problem and get rid of trial–error step of Algorithm 1, a new algorithm is proposed here. The simulations are carried out using the control rule based on this algorithm and these results are presented. [ABSTRACT FROM AUTHOR]

This paper presents a dynamic compensation concept to grapple with the dynamic defects of a traditional robot arm, especially while performing high-speed endpoint regulations. The proposed high-speed dynamic compensation concept offers a new point of view for cooperating with a traditional manipulator to realize highly dexterous performance of manipulations. The concept is realized through adoption of a high-speed light-weight actuator as well as endpoint closed loop configured high-speed cameras. The dynamic compensation is analyzed experimentally with 1000 Hz visual feedback and a high-speed finger for a robot arm in the case of one degree of freedom. The advantage of the proposed approach is that the modeling for the robot system’s dynamics is not needed, whereas it is necessary and trivial in order to realize high-speed regulations by traditional approaches. Thus, the control issue becomes easier with the proposed approach. As an application for this concept, fast peg-and-hole alignment with large position and attitude uncertainty is studied. The alignment algorithm is based on a visual compliance strategy. Alignment experiments show that with the proposed concept of dynamic compensation as well as visual compliant motion control, robust and fast convergence was realized for most cases. [ABSTRACT FROM AUTHOR]

In this paper, dimensional optimization of a six-degrees-of-freedom (DOF) 3-CCC (C: cylindrical joint) type asymmetric parallel manipulator (APM) is performed by using particle swarm optimization (PSO). The 3-CCC APM constructed by defining three angle and three distance constraints between base and moving platforms is a member of 3D3A generalized Stewart–Gough platform (GSP) type parallel manipulators. The dimensional optimization purposes to find the optimum limb lengths, lengths of line segments on the base and moving platforms, attachment points of the line segments on the base platform, the orientation angles of the moving platform, and position of the end-effector in the reachable workspace in order to maximize the translational and orientational dexterous workspaces of the 3-CCC APM, separately. The dexterous workspaces are obtained by applying condition number and minimum singular values of the Jacobian matrix. The optimization results are compared with the traditional GSP manipulator for illustrating the kinematic performance of 3-CCC APM. Optimizations show that 3-CCC APM have superior dexterous workspace characteristics than the traditional GSP manipulator. [ABSTRACT FROM AUTHOR]

Although numerous swarm robotic systems have already been developed, they have exhibited limited adaptability. This was partly because the previous researchers designed the control schemes on the basis of informational interaction, without considering the physical effects of the environment. To tackle this problem, we employ an unconventional approach: we design a control scheme for swarm robots based on their physical interaction in a hydrodynamic field, inspired by biological swarming. Through simulations using a smoothed particle hydrodynamics method, we show that the proposed control scheme allows agents to form an ordered swarm in response to their environment. [ABSTRACT FROM AUTHOR]

Nucleation rate is a very sensitive function of the temperature and vapor mole fraction. Analytical approximation schemes for the mean nucleation rate in turbulent flows are derived using Laplace’s approximation method. The schemes only require the derivative of the nucleation rate function and the probability density function (pdf) of the vapor mole fraction and/or temperature at the point of maximum nucleation rate. Based on the relation between the mole fraction and temperature, i.e., linearly correlated or not, different approximation schemes are developed. Numerical examples are constructed to investigate the accuracy of these approximation. In the examples, the pdfs of mole fraction and/or temperature in various turbulent flows are assumed to come from the beta distribution with five distinct forms. The mean nucleation rate of dibutyl phthalate (DBP) aerosol in these turbulent flows are calculated from the approximation schemes, and compared with exact numerical integration. The relative errors are less than 1% for cases when nucleation rate diminishes at the bounds of temperature fluctuations, and no more than 50% for all studied examples. Furthermore, the approximation schemes are not sensitive to the precise form of the pdfs. Hence, these developed approximation schemes can be used to estimate the mean nucleation rate in a broad range of turbulent flows conveniently. Copyright 2014 American Association for Aerosol Research [ABSTRACT FROM AUTHOR]

Human exposure to particulate matter (PM) air pollution is associated with human morbidity and mortality. The mechanisms by which PM impacts human health are unresolved, but evidence suggests that PM intake leads to cellular oxidative stress through the generation of reactive oxygen species (ROS). Therefore, reliable tools are needed for estimating the oxidant generating capacity, or oxidative load, of PM at high temporal resolution (minutes to hours). One of the most widely reported methods for assessing PM oxidative load is the dithiothreitol (DTT) assay. The traditional DTT assay utilizes filter-based PM collection in conjunction with chemical analysis to determine the oxidation rate of reduced DTT in solution with PM. However, the traditional DTT assay suffers from poor time resolution, loss of reactive species during sampling, and high limit of detection. Recently, a new DTT assay was developed that couples a particle-into-liquid-sampler with microfluidic-electrochemical detection. This “on-line” system allows high temporal resolution monitoring of PM reactivity with improved detection limits. This study reports on a laboratory comparison of the traditional and on-line DTT approaches. An urban dust sample was aerosolized in a laboratory test chamber at three atmospherically relevant concentrations. The on-line system gave a stronger correlation between DTT consumption rate and PM mass (R2= 0.69) than the traditional method (R2= 0.40) and increased precision at high temporal resolution, compared to the traditional method. Copyright 2014 American Association for Aerosol Research [ABSTRACT FROM AUTHOR]