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The prognostic value of p53 expression in negative surgical margins of early glottic carcinoma in the prediction of local recurrences.
- Source :
- Acta Oto-Laryngologica; May2014, Vol. 134 Issue 5, p525-530, 6p
- Publication Year :
- 2014
-
Abstract
- Conclusions: p53 overexpression (>5%) in the surgical margins was more valuable than in the primary tumor tissue for the prediction of local recurrence among surgically treated early glottic cancers. This is the first study to compare p53 values in both primary tumor and surgical margin tissues of the same patients with early glottic cancers. Objective: To assess the prognostic value of p53 expression in the surgical margins of early glottic cancers treated with external laryngeal surgery in the prediction of local recurrences. Methods: Fifteen patients with early glottic cancer with local recurrences (group 1) and 15 without any recurrences (group 2) were included in the study. p53 expression was determined in both the tumor and the tumor-negative surgical margins. Results: Median p53 in the primary tumor was 55% (interquartile range (IQR) = 67) and 5% (IQR = 71) in groups 1 and 2, respectively ( p = 0.178). Median p53 in the surgical margin was 11% (IQR = 13) and 2% (IQR = 2) in groups 1 and 2, respectively ( p = 0.001). In the logistic regression analysis only surgical margin p53 value was significant in the prediction of recurrences (odds ratio (OR) = 1.68, 95% CI = 1.1-2.6, p = 0.017). Receiver operating characteristic (ROC) curve analysis demonstrated that the area under the curve was 0.86 ( p = 0.002) and 0.65 ( p = 0.180) in the surgical margin and the primary tumor, respectively. [ABSTRACT FROM AUTHOR]
- Subjects :
- LARYNGEAL tumors
CHI-squared test
CONFIDENCE intervals
STATISTICAL correlation
EPIDEMIOLOGY
FISHER exact test
STATISTICS
TUMOR markers
U-statistics
DISEASE relapse
DATA analysis
RETROSPECTIVE studies
RECEIVER operating characteristic curves
DATA analysis software
DESCRIPTIVE statistics
PROGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00016489
- Volume :
- 134
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Acta Oto-Laryngologica
- Publication Type :
- Academic Journal
- Accession number :
- 95426297
- Full Text :
- https://doi.org/10.3109/00016489.2013.871747