1. Direct hydroxyethylation of amines by carbohydrates via ruthenium catalysis.
- Author
-
Jia, Le, Makha, Mohamed, Du, Chen-Xia, Quan, Zheng-Jun, Wang, Xi-Cun, and Li, Yuehui
- Subjects
CARBOHYDRATES ,RUTHENIUM catalysts ,RUTHENIUM ,AMINES ,CATALYSIS ,AROMATIC amines - Abstract
An efficient and halogen-free catalytic methodology for the synthesis of β-amino alcohols from aromatic amines and biomass-derived carbohydrates is demonstrated for the first time. The activation of C5/C6 sugars by a ruthenium catalyst selectively generates the C2 alkylating reagent glycolaldehyde. The transformation involves metal-catalyzed hydrogen borrowing for the reduction of the imine intermediate. A series of arylamines bearing various substituents were successfully transformed into the desired products in good to excellent yields. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF