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Direct hydroxyethylation of amines by carbohydrates via ruthenium catalysis.
- Source :
- Green Chemistry; 6/7/2019, Vol. 21 Issue 11, p3127-3132, 6p
- Publication Year :
- 2019
-
Abstract
- An efficient and halogen-free catalytic methodology for the synthesis of β-amino alcohols from aromatic amines and biomass-derived carbohydrates is demonstrated for the first time. The activation of C5/C6 sugars by a ruthenium catalyst selectively generates the C2 alkylating reagent glycolaldehyde. The transformation involves metal-catalyzed hydrogen borrowing for the reduction of the imine intermediate. A series of arylamines bearing various substituents were successfully transformed into the desired products in good to excellent yields. [ABSTRACT FROM AUTHOR]
- Subjects :
- CARBOHYDRATES
RUTHENIUM catalysts
RUTHENIUM
AMINES
CATALYSIS
AROMATIC amines
Subjects
Details
- Language :
- English
- ISSN :
- 14639262
- Volume :
- 21
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Green Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 136816681
- Full Text :
- https://doi.org/10.1039/c9gc01195a