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Two Cu(II) metal complexes, {[Cu(bmem)(CH 3 OH)(CH 3 O)](ClO 4)} n (1) and {[Cu(bmem)(CH 3 O)(SCN)](CH 3 OH) 0.75 } n (2) based on 1-(benzotriazole-1-methyl) -1-(2-ethylimidazole) (bmem) were synthesized. The X-ray single crystal diffraction analysis reveals that complexes 1 and 2 both display 1D chain structure containing binuclear copper units. Then the ligand and complexes 1 and 2 were examined for hypoglycemic activity against α-amylase and antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and found that two Cu(II) complexes showed more activity than the ligand bmem. Both complexes 1 and 2 have strong inhibitory effects on α-amylase, and the IC 50 values of complexes 1 (1.97 mg/mL) and 2 (1.83 mg/mL) are lower than that of acarbose (2.3 mg/mL) and ligand (10.89 mg/mL). The scavenging rates on DPPH radical of complexes 1 (80.46%, 150 μg/mL) and 2 (63.08%, 150 μg/mL) are significantly higher than that of ligand (6.92%, 150 μg/mL). In addition, the fluorescence properties and thermal stability of metal complexes were determined. Image 1 • Two new benzotriazole-based Cu(II) complexes 1 and 2 were synthesized. • Complexes 1 and 2 display 1D chain structure containing binuclear copper units. • The hypoglycemic activities against α-amylase of complexes 1 and 2 were investigated in vitro. • The antioxidant activities of complexes 1 and 2 were evaluated by the DPPH free radical scavenging assay. [ABSTRACT FROM AUTHOR]

Three new complexes formulated as [Cu(mbmb) 2 Cl 2 ] (1), [Cu(mbmb) 2 (NO 3) 2 ] (2), and [Zn(mbmb) 2 Cl 2 ] (3) (mbmb = 1-[(2-methyl-1H-benzoimidazol-1-yl)methyl]-1H-benzotriazole) have been synthesized and characterized. Complexes 1 – 3 showed mononuclear structures and the central metal ions of complexes 1 – 3 exhibited a four-coordinated environment. We evaluated the antioxidant activity against DPPH and antidiabetic activity against α-amylase of complexes 1 – 3 and ligand (mbmb) in vitro. The results of DPPH free radical scavenging assay showed that complexes 1 and 2 exhibited higher antioxidant activity among the synthesized compounds and their IC 50 values were 43.72 μg/mL and 43.76 μg/mL, respectively. The IC 50 values in vitro antidiabetic studies of complex 1 (0.74 mg/mL) and complex 2 (1.00 mg/mL) were much smaller than those of standard acarbose (2.34 mg/mL) and the ligand mbmb (39.87 mg/mL), which showed effective inhibition on α-amylase. Additionally, the solid-state fluorescent properties of these three complexes and ligand mbmb were investigated at room temperature. Unlabelled Image • Three new benzimidazole-based Cu(II)/Zn(II) complexes 1 – 3 were synthesized. • The structure of complexes 1 – 3 was characterized adequately by X-ray study. • The antioxidant activities of complexes 1 – 3 were evaluated by the DPPH free radical scavenging assay. • The antidiabetic activities against α-amylase of complexes 1 – 3 were investigated in vitro. [ABSTRACT FROM AUTHOR]

Three new Zn(II) complexes, namely [Zn(emimb) 2 Cl 2 (1), [Zn(dmimb) 2 Cl 2 (2) and [Zn(bmem) 2 (SCN) 2 (3), have been synthesized using the benzotriazole-based ligands, 1-((2-ethyl-4-methyl-1H-imidazol-1-yl)methyl)-1H-benzotriazole (emimb), 1-((2,4-dimethyl-1H-imidazol-1-yl)methyl)-1H-benzotriazole (dmimb) and 1-((2-ethyl-1H-imidazol-1-yl)methyl)-1H-benzotriazole (bmem). All the complexes were fully characterized by elemental analysis, IR spectroscopy, 1H NMR spectroscopy and single-crystal X-ray diffraction analysis. Complexes 1–3 show mononuclear structures and the central Zn(II) ion of 1 – 3 is four-coordinated in a distorted tetrahedral coordination geometry. Complex 2 presents an interesting 3-D network through two different intermolecular π-π stacking interactions. The antidiabetic activities against α-amylase of ligands and complexes 1–3 are investigated in vitro. The results indicate that the three Zn(II) complexes inhibit α-amylase more strongly than free ligands. Antioxidant tests in vitro show that the complex 3 possesses a mild antioxidant activity against 1,1-diphenyl-picrylhydrazyl (DPPH). In addition, the solid-state photoluminescence properties of ligands and their Zn(II) complexes have been investigated. Image 1 • Three new benzotriazole-based Zn(II) complexes 1–3 were synthesized. • The structure of complexes 1–3 was characterized adequately by X-ray study. • The antidiabetic activities of complexes 1–3 were investigated against α-amylase in vitro. • The antioxidant activities of complexes 1–3 were evaluated by the DPPH free radical scavenging assay. [ABSTRACT FROM AUTHOR]

• A novel Co(II) complex (1) was synthesized and characterized adequately by X-ray study. • The Co(II) complex exhibits a interesting 3-D framework with the Schläfli symbol of (4·82) 2 (84·122)(42·84) 2. • The antidiabetic activity against α-amylase of complex 1 was investigated in vitro. • The antioxidant activity of complex 1 was evaluated by the DPPH free radical scavenging assay. A novel 3D Co(II) complex {[Co 3 (TTTMB) 4 (SCN) 6 ]·3.5H 2 O} n (1) has been synthesized through the reaction of a flexible tripodal ligand 1,3,5-tris(triazol-1-ylmethyl)- 2,4,6-trimethylbenzene (TTTMB) with Co(NO 3) 2 and KSCN. Single crystal X-ray diffraction determination shows that complex 1 crystallizes in the monoclinic space group C2/c and exhibits three crystallographically independent Co(II) ions with the similar coordination environment but different bond lengths and angles. The overall structure of complex 1 can be described as a (3,4)-connected network with the topological notation of (4·82) 2 (84·122)(42·84) 2. The antidiabetic activity against α-amylase and antioxidant activity against 1,1-diphenyl-2-picrylhydrazil (DPPH) of complex 1 are evaluated in vitro. The IC 50 values of the complex 1 on α-amylase and DPPH are 1.27 mg/mL and 1.53 mg/mL, respectively, which are lower than those of corresponding standard acarbose (2.89 mg/mL) and vitamin E (2.39 mg/mL), indicating that the complex 1 is a new potential antidiabetic and antioxidant drug. Additionally, the solid-state fluorescent properties and thermal stability of the complex are investigated at room temperature. [ABSTRACT FROM AUTHOR]