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Synthesis, crystal structure and biological properties of two Cu(II) complexes based on 1-(benzotriazole-1-methyl)-1-(2-ethylimidazole).
- Source :
-
Journal of Molecular Structure . Oct2019, Vol. 1193, p348-356. 9p. - Publication Year :
- 2019
-
Abstract
- Two Cu(II) metal complexes, {[Cu(bmem)(CH 3 OH)(CH 3 O)](ClO 4)} n (1) and {[Cu(bmem)(CH 3 O)(SCN)](CH 3 OH) 0.75 } n (2) based on 1-(benzotriazole-1-methyl) -1-(2-ethylimidazole) (bmem) were synthesized. The X-ray single crystal diffraction analysis reveals that complexes 1 and 2 both display 1D chain structure containing binuclear copper units. Then the ligand and complexes 1 and 2 were examined for hypoglycemic activity against α-amylase and antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and found that two Cu(II) complexes showed more activity than the ligand bmem. Both complexes 1 and 2 have strong inhibitory effects on α-amylase, and the IC 50 values of complexes 1 (1.97 mg/mL) and 2 (1.83 mg/mL) are lower than that of acarbose (2.3 mg/mL) and ligand (10.89 mg/mL). The scavenging rates on DPPH radical of complexes 1 (80.46%, 150 μg/mL) and 2 (63.08%, 150 μg/mL) are significantly higher than that of ligand (6.92%, 150 μg/mL). In addition, the fluorescence properties and thermal stability of metal complexes were determined. Image 1 • Two new benzotriazole-based Cu(II) complexes 1 and 2 were synthesized. • Complexes 1 and 2 display 1D chain structure containing binuclear copper units. • The hypoglycemic activities against α-amylase of complexes 1 and 2 were investigated in vitro. • The antioxidant activities of complexes 1 and 2 were evaluated by the DPPH free radical scavenging assay. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00222860
- Volume :
- 1193
- Database :
- Academic Search Index
- Journal :
- Journal of Molecular Structure
- Publication Type :
- Academic Journal
- Accession number :
- 137014534
- Full Text :
- https://doi.org/10.1016/j.molstruc.2019.05.036