1. Nanodiamonds with silicon vacancy defects for non-toxic photostable fluorescent labeling of neural precursor cells
- Author
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Merson, Tobias D., Castelletto, Stefania, Aharonovich, Igor, Turbic, Alisa, Kilpatrick, Trevor J., and Turnley, Ann M.
- Subjects
Physics - Biological Physics ,Condensed Matter - Materials Science ,Quantitative Biology - Biomolecules - Abstract
Nanodiamonds (NDs) containing silicon vacancy (SiV) defects were evaluated as a potential biomarker for the labeling and fluorescent imaging of neural precursor cells (NPCs). SiV-containing NDs were synthesized using chemical vapor deposition and silicon ion implantation. Spectrally, SiV-containing NDs exhibited extremely stable fluorescence and narrow bandwidth emission with an excellent signal to noise ratio exceeding that of NDs containing nitrogen-vacancy (NV) centers. NPCs labeled with NDs exhibited normal cell viability and proliferative properties consistent with biocompatibility. We conclude that SiVcontaining NDs are a promising biomedical research tool for cellular labeling and optical imaging in stem cell research., Comment: The paper was accepted for publication in Optics letters
- Published
- 2013
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